Phenytoin, a drug with a low extraction ratio, will be most influenced by which critical illness–related metabolic abnormality?
A. Decreased hepatic blood flow Wrong Choice!
B. Decreased intrinsic clearance Correct Choice
C. Decreased protein binding Wrong Choice!
D. Decreased acetylation Wrong Choice!
Answer:B
Phenytoin, a drug with a low extraction ratio, will be most influenced by which critical illness–related metabolic abnormality?
A. Decreased hepatic blood flow Wrong Choice! B. Decreased intrinsic clearance Correct Choice C. Decreased protein binding Wrong Choice! D. Decreased acetylation Wrong Choice!