An 81-year-old woman is transferred to you from another hospital with a history of methicillin-resistant Staphylococcus aureus bacteremia that led to prosthetic hardware infection of a recent total hip arthroplasty. Her bacteremia cleared, and rifampin was initiated on the day of transfer, while also continuing vancomycin. She remains intubated and sedated on a ventilator for respiratory failure due to comorbid chronic obstructive pulmonary disease. You consider starting corticosteroids for her exacerbation of her chronic obstructive pulmonary disease. Before starting any new medications for this patient, what should you do?
A. Check for drug interactions, as rifampin is a potent cytochrome P450 inducer Correct Choice
B. Use a lower corticosteroid dose than you would usually give Wrong Choice!
C. Stop rifampin, give corticosteroids instead Wrong Choice!
D. Measure rifampin levels to determine whether cytochrome P450 has already been induced Wrong Choice!
Answer:A
An 81-year-old woman is transferred to you from another hospital with a history of methicillin-resistant Staphylococcus aureus bacteremia that led to prosthetic hardware infection of a recent total hip arthroplasty. Her bacteremia cleared, and rifampin was initiated on the day of transfer, while also continuing vancomycin. She remains intubated and sedated on a ventilator for respiratory failure due to comorbid chronic obstructive pulmonary disease. You consider starting corticosteroids for her exacerbation of her chronic obstructive pulmonary disease. Before starting any new medications for this patient, what should you do?
A. Check for drug interactions, as rifampin is a potent cytochrome P450 inducer Correct Choice B. Use a lower corticosteroid dose than you would usually give Wrong Choice! C. Stop rifampin, give corticosteroids instead Wrong Choice! D. Measure rifampin levels to determine whether cytochrome P450 has already been induced Wrong Choice!