Fentanyl, a drug with a high extraction ratio, will be most influenced by which critical illness–related metabolic abnormality?
A. Decreased hepatic blood flow Correct Choice
B. Decreased intrinsic clearance Wrong Choice!
C. Decreased protein binding Wrong Choice!
D. Decreased functional hepatocytes Wrong Choice!
Answer:A
Fentanyl, a drug with a high extraction ratio, will be most influenced by which critical illness–related metabolic abnormality?
A. Decreased hepatic blood flow Correct Choice B. Decreased intrinsic clearance Wrong Choice! C. Decreased protein binding Wrong Choice! D. Decreased functional hepatocytes Wrong Choice!