What is the most likely pharmacokinetic explanation for why this medication produced an exaggerated clinical effect in this patient with CKD?
A. With lowered protein binding in CKD, there is an increase in the free fraction of alprazolam, potentiating its clinical effect Correct Choice
B. Secondary to impaired renal excretion, there is a rapid accumulation of the metabolite of alprazolam, causing oversedation Wrong Choice!
C. Owing to the decrease in volume of distribution found in CKD patients, there is a higher concentration of alprazolam in the plasma, leading to greater clinical effect Wrong Choice!
D. The metabolism of alprazolam is heavily dependent on the kidneys. In CKD, the decreased metabolism of benzodiazepines can often lead to an overdose of the medication Wrong Choice!
Answer:A
What is the most likely pharmacokinetic explanation for why this medication produced an exaggerated clinical effect in this patient with CKD?
A. With lowered protein binding in CKD, there is an increase in the free fraction of alprazolam, potentiating its clinical effect Correct Choice B. Secondary to impaired renal excretion, there is a rapid accumulation of the metabolite of alprazolam, causing oversedation Wrong Choice! C. Owing to the decrease in volume of distribution found in CKD patients, there is a higher concentration of alprazolam in the plasma, leading to greater clinical effect Wrong Choice! D. The metabolism of alprazolam is heavily dependent on the kidneys. In CKD, the decreased metabolism of benzodiazepines can often lead to an overdose of the medication Wrong Choice!