A one and Half year old boy is diagnosed with a degenerative disease involving the basal ganglia. Further studies show less than 1 % normal activity of the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT). Which of the following enzymes is most likely to show increased activity in this patient?
A. Arginase
B. Xanthine oxidase
C. 3,4 dihydroxy phenylalanine (dopa) decarboxylase
D. Mitochondrial carbamoyl phosphate synthetase
Answer:B
A one and Half year old boy is diagnosed with a degenerative disease involving the basal ganglia. Further studies show less than 1 % normal activity of the enzyme hypoxanthine guanine phosphoribosyl transferase (HGPRT). Which of the following enzymes is most likely to show increased activity in this patient?
A. Arginase B. Xanthine oxidase C. 3,4 dihydroxy phenylalanine (dopa) decarboxylase D. Mitochondrial carbamoyl phosphate synthetase