) The reference dose (RfD) is generally determined by applying which of the following default procedures?
A.) an uncertainty factor of 100 is applied to the NOAEL in chronic animal studies
B.) a risk factor of 1000 is applied to the NOAEL in chronic animal studies
C.) a risk factor of 10,000 is applied to the NOAEL in subchronic animal studies
D.) an uncertainty factor between 10,000 and 1 million is applied to the NOEL from chronic animal studies
Answer:A
) The reference dose (RfD) is generally determined by applying which of the following default procedures?
A.) an uncertainty factor of 100 is applied to the NOAEL in chronic animal studies B.) a risk factor of 1000 is applied to the NOAEL in chronic animal studies C.) a risk factor of 10,000 is applied to the NOAEL in subchronic animal studies D.) an uncertainty factor between 10,000 and 1 million is applied to the NOEL from chronic animal studies