Which of the following statement(s) is/are true concerning tumor necrosis factor (TNF)?
A. TNF is a product of activated macrophages secreted in response to contact with endotoxin or lipopolysaccharide, antibody complexes, or inflammatory stimuli
B. The liver and gut appear to be a major source of TNF following hypoperfusion
C. Circulating levels of TNF correlate well with severity of tissue injury in shock
D. Recently completed clinical trials of anti-TNF antibody in septic patients shows a marked improvement in survival
Answer:A
Which of the following statement(s) is/are true concerning tumor necrosis factor (TNF)?
A. TNF is a product of activated macrophages secreted in response to contact with endotoxin or lipopolysaccharide, antibody complexes, or inflammatory stimuli B. The liver and gut appear to be a major source of TNF following hypoperfusion C. Circulating levels of TNF correlate well with severity of tissue injury in shock D. Recently completed clinical trials of anti-TNF antibody in septic patients shows a marked improvement in survival