Which of the following statement(s) is/are correct concerning the pathophysiology of frostbite?
A. Frostbite injury may have two components: initial freeze injury and a reperfusion injury that follows during rewarming
B. The formation of extracellular ice crystals in the tissue begins to occur at -10°C
C. The release of oxygen free radicals and arachidonic acid metabolites aggravates vasoconstriction and platelet and leukocyte aggregation
D. Experimental evidence suggests that a substantial component of severe cold injury may be mediated due to platelet aggregation
Answer:A
Which of the following statement(s) is/are correct concerning the pathophysiology of frostbite?
A. Frostbite injury may have two components: initial freeze injury and a reperfusion injury that follows during rewarming B. The formation of extracellular ice crystals in the tissue begins to occur at -10°C C. The release of oxygen free radicals and arachidonic acid metabolites aggravates vasoconstriction and platelet and leukocyte aggregation D. Experimental evidence suggests that a substantial component of severe cold injury may be mediated due to platelet aggregation