Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?
A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains
B. By the combination of different heavy and light chains that form the antigen binding site
C. Antibody proteins can physically change their shape to bind different epitopes
D. Both (a) and (b)
Answer:D
Numerous antibodies can be prepared, against one antigen, each binds to unique epitopes. How is this antibody diversity generated?
A. By rearrangements of the DNA encoding the variable regions of the heavy and light chains B. By the combination of different heavy and light chains that form the antigen binding site C. Antibody proteins can physically change their shape to bind different epitopes D. Both (a) and (b)