Which of the following statement(s) is/are true concerning ischemia reperfusion injury?
A. During ischemia, ATP degradation results in increased plasma and intracellular levels of hypoxanthine and xanthene
B. Oxygen free radicals such as the superoxide radical are involved in the expression of the proinflammatory phenotype of endothelial cells, macrophages and neutrophils
C. The intracellular adhesion molecule-1 (ICAN-1) contributes to injury and disruption of the endothelial lining, with extensive capillary leak and resultant interstitial edema
D. Animal models have demonstrated that passive immunization with antibodies to neutrophil adhesive complex lessen the ischemic/reperfusion microvascular injury
Answer:A
Which of the following statement(s) is/are true concerning ischemia reperfusion injury?
A. During ischemia, ATP degradation results in increased plasma and intracellular levels of hypoxanthine and xanthene B. Oxygen free radicals such as the superoxide radical are involved in the expression of the proinflammatory phenotype of endothelial cells, macrophages and neutrophils C. The intracellular adhesion molecule-1 (ICAN-1) contributes to injury and disruption of the endothelial lining, with extensive capillary leak and resultant interstitial edema D. Animal models have demonstrated that passive immunization with antibodies to neutrophil adhesive complex lessen the ischemic/reperfusion microvascular injury