The complement system consists of a series of serum proteins that exist in a quiescent or very low-level state of activation in the uninfected host. Which of the following statement(s) is/are true concerning complement activation?
A. The alternate (properdin) pathway of complement activation can occur directly through contact with fungal or bacterial cell wall compounds
B. Complement component fragments may serve to decrease vascular permeability
C. Excessive complement activation can produce deleterious effects
D. Fragments of certain complement components serve as chemoattractants to additional cellular components of the host defense mechanism
Answer:A
The complement system consists of a series of serum proteins that exist in a quiescent or very low-level state of activation in the uninfected host. Which of the following statement(s) is/are true concerning complement activation?
A. The alternate (properdin) pathway of complement activation can occur directly through contact with fungal or bacterial cell wall compounds B. Complement component fragments may serve to decrease vascular permeability C. Excessive complement activation can produce deleterious effects D. Fragments of certain complement components serve as chemoattractants to additional cellular components of the host defense mechanism