Which of the following statements regarding alpha-1-antitrypsin deficiency is/are correct?
A. Alpha-1-antitrypsin is a plasma elastase inhibitor
B. Most homozygous patients develop chronic obstructive pulmonary disease
C. The spleen is the primary site of alpha-1-antitrypsin synthesis
D. Intracellular accumulation of abnormal protein occurs in hepatocytes
Answer:A
Which of the following statements regarding alpha-1-antitrypsin deficiency is/are correct?
A. Alpha-1-antitrypsin is a plasma elastase inhibitor B. Most homozygous patients develop chronic obstructive pulmonary disease C. The spleen is the primary site of alpha-1-antitrypsin synthesis D. Intracellular accumulation of abnormal protein occurs in hepatocytes