) Which of the following assumptions is NOT correct regarding risk assessment for male reproductive effects in the absence of mechanistic data?
A.) an agent that produces an adverse reproductive effect in experimental animals is assumed to pose a potential reproductive hazard to humans
B.) in general, a non-threshold is assumed for the dose-response curve for male reproductive toxicity
C.) effects of xenobiotics on male reproduction are assumed to be similar across species unless demonstrated otherwise
D.) the most sensitive species should be used to estimate human risk
Answer:B
) Which of the following assumptions is NOT correct regarding risk assessment for male reproductive effects in the absence of mechanistic data?
A.) an agent that produces an adverse reproductive effect in experimental animals is assumed to pose a potential reproductive hazard to humans B.) in general, a non-threshold is assumed for the dose-response curve for male reproductive toxicity C.) effects of xenobiotics on male reproduction are assumed to be similar across species unless demonstrated otherwise D.) the most sensitive species should be used to estimate human risk