An antibody made against the antigen tetanus toxoid (TT) reacts with it even when the TT is denatured by disrupting all disulfide bonds. Another antibody against TT fails to react when the TT is similarly denatured. The most likely explanation can be stated as follows
A. the first antibody is specific for several epitopes expressed by TT
B. the first antibody is specific for the primary amino acid sequence of TT, whereas the second is specific for conformational determinants
C. the second antibody is specific for disulfide bonds
D. the first antibody has a higher affinity for TT
Answer:B
An antibody made against the antigen tetanus toxoid (TT) reacts with it even when the TT is denatured by disrupting all disulfide bonds. Another antibody against TT fails to react when the TT is similarly denatured. The most likely explanation can be stated as follows
A. the first antibody is specific for several epitopes expressed by TT B. the first antibody is specific for the primary amino acid sequence of TT, whereas the second is specific for conformational determinants C. the second antibody is specific for disulfide bonds D. the first antibody has a higher affinity for TT