A tuberculosis patient undergoing antibiotic therapy with Rifamateâ, which is a combination of isoniazid and rifampin. This patient has non-insulin-dependent diabetes and is prescribed a sulfonylurea hypoglycemic. However, the diabetes treatment is not effective. Which of the following is a reasonable explanation for the ineffectiveness of the hypoglycemic drug?
A. Isoniazid combines with pyridoxal resulting in a vitamin-B6 deficiency
B. Rifampin combines with pyridoxal resulting in a vitamin-B6 deficiency
C. Rifampin induces hepatic metabolism of sulfonylureas
D. Isoniazid induces hepatic metabolism of sulfonylureas
Answer:C
A tuberculosis patient undergoing antibiotic therapy with Rifamateâ, which is a combination of isoniazid and rifampin. This patient has non-insulin-dependent diabetes and is prescribed a sulfonylurea hypoglycemic. However, the diabetes treatment is not effective. Which of the following is a reasonable explanation for the ineffectiveness of the hypoglycemic drug?
A. Isoniazid combines with pyridoxal resulting in a vitamin-B6 deficiency B. Rifampin combines with pyridoxal resulting in a vitamin-B6 deficiency C. Rifampin induces hepatic metabolism of sulfonylureas D. Isoniazid induces hepatic metabolism of sulfonylureas