Fibrinolytic therapy is based on activation of plasminogen, the inactive proteolytic enzyme of plasma that binds to fibrin during the formation of thrombosis. Activation of plasminogen to plasmin results in selective thrombolysis at the fibrin clot surface. Which of the following statement(s) is/are true concerning agents used in thrombolytic therapy?
A. Streptokinase is a bacterial protein which is antigenic in humans, resulting in allergic reactions in up to l5% of cases
B. Tissue plasminogen activator acts directly on plasmin without an intermediate drug–plasmin complex
C. The half-life of urokinase, streptokinase, and TPA all exceed 30 minutes
D. Streptokinase is significantly cheaper than urokinase or TPA
Answer:A
Fibrinolytic therapy is based on activation of plasminogen, the inactive proteolytic enzyme of plasma that binds to fibrin during the formation of thrombosis. Activation of plasminogen to plasmin results in selective thrombolysis at the fibrin clot surface. Which of the following statement(s) is/are true concerning agents used in thrombolytic therapy?
A. Streptokinase is a bacterial protein which is antigenic in humans, resulting in allergic reactions in up to l5% of cases B. Tissue plasminogen activator acts directly on plasmin without an intermediate drug–plasmin complex C. The half-life of urokinase, streptokinase, and TPA all exceed 30 minutes D. Streptokinase is significantly cheaper than urokinase or TPA