A 60-year-old man is being treated for nosocomial pneumonia with tobramycin and piperacillin. Tobramycin peak and trough blood levels are ordered. Which of the following statements is true?
A. Trough concentrations should not be drawn, they are not important since tobramycin is a concentration-dependent bactericidal drug
B. Peak concentrations, if drawn while the distribution phase is still predominant, will result in falsely elevated values
C. Peak and trough concentrations can be drawn within 2-3 hours of each other and will not adversely affect any of the other calculated pharmacokinetic parameters such as half-life
D. Peak concentrations, if drawn while the distribution phase is still predominant, will result in falsely low values
Answer:B
A 60-year-old man is being treated for nosocomial pneumonia with tobramycin and piperacillin. Tobramycin peak and trough blood levels are ordered. Which of the following statements is true?
A. Trough concentrations should not be drawn, they are not important since tobramycin is a concentration-dependent bactericidal drug B. Peak concentrations, if drawn while the distribution phase is still predominant, will result in falsely elevated values C. Peak and trough concentrations can be drawn within 2-3 hours of each other and will not adversely affect any of the other calculated pharmacokinetic parameters such as half-life D. Peak concentrations, if drawn while the distribution phase is still predominant, will result in falsely low values