Based on the half-life and onset of action of warfarin, which of the following is the optimal management of this drug in the case of uncomplicated major surgery?
A. Warfarin should be stopped 5 days before surgery and restarted as soon as the patient can take oral medications after surgery.
B. Warfarin should be stopped 2 days before surgery and restarted as soon as the patient can take oral medications after surgery.
C. Warfarin should be stopped 5 days before surgery and restarted at least 5 days after surgery.
D. Warfarin should be stopped 2 days before surgery and restarted at least 5 days after surgery.
Answer:A
Based on the half-life and onset of action of warfarin, which of the following is the optimal management of this drug in the case of uncomplicated major surgery?
A. Warfarin should be stopped 5 days before surgery and restarted as soon as the patient can take oral medications after surgery. B. Warfarin should be stopped 2 days before surgery and restarted as soon as the patient can take oral medications after surgery. C. Warfarin should be stopped 5 days before surgery and restarted at least 5 days after surgery. D. Warfarin should be stopped 2 days before surgery and restarted at least 5 days after surgery.