Based on the half-life and onset of action of warfarin, which of the follow ing is the optimal management of this drug in the case of uncomplicated major surgery?
A. Warfarin should be stopped 5 days before surgery and restarted as soon as the patient can take oral medications after surgery.
B. Warfarin should be stopped 2 days before surgery and restarted as soon as the patient can take oral medications after surgery.
C. Warfarin should be stopped 5 days before surgery and restarted at least 5 days after surgery.
D. Warfarin should be stopped 2 days before surgery and restarted at least 5 days after surgery.
Answer:A
Based on the half-life and onset of action of warfarin, which of the follow ing is the optimal management of this drug in the case of uncomplicated major surgery?
A. Warfarin should be stopped 5 days before surgery and restarted as soon as the patient can take oral medications after surgery. B. Warfarin should be stopped 2 days before surgery and restarted as soon as the patient can take oral medications after surgery. C. Warfarin should be stopped 5 days before surgery and restarted at least 5 days after surgery. D. Warfarin should be stopped 2 days before surgery and restarted at least 5 days after surgery.