Which of the following statements regarding alpha-1-antitrypsin deficiency is/are correct?
A.	Alpha-1-antitrypsin is a plasma elastase inhibitor
B.	Most homozygous patients develop chronic obstructive pulmonary disease
C.	The spleen is the primary site of alpha-1-antitrypsin synthesis
D.	Intracellular accumulation of abnormal protein occurs in hepatocytes
Answer:A
Which of the following statements regarding alpha-1-antitrypsin deficiency is/are correct?
A.	Alpha-1-antitrypsin is a plasma elastase inhibitor B.	Most homozygous patients develop chronic obstructive pulmonary disease C.	The spleen is the primary site of alpha-1-antitrypsin synthesis D.	Intracellular accumulation of abnormal protein occurs in hepatocytes