A 45-year-old male takes pravastatin for hypercholesterolemia; however, his cholesterol level remains above target at maximal doses. Cholestyramine is added to the therapeutic regimen. What drug-drug interaction can occur?
A. Both will show a synergistic effect
B. Cholestyramine inhibits gastrointestinal (GI) absorption of pravastatin
C. Pravastatin is a direct antagonist of cholestyramine
D. The combination causes elevated very-low-density lipoprotein (VLDL)
Answer:B
A 45-year-old male takes pravastatin for hypercholesterolemia; however, his cholesterol level remains above target at maximal doses. Cholestyramine is added to the therapeutic regimen. What drug-drug interaction can occur?
A. Both will show a synergistic effect B. Cholestyramine inhibits gastrointestinal (GI) absorption of pravastatin C. Pravastatin is a direct antagonist of cholestyramine D. The combination causes elevated very-low-density lipoprotein (VLDL)