Geriatric patients may have following distribution effects?
A. Decreased total body water, resulting in decreased volume of distribution (Va) of water-soluble drugs (increased serum concentrations)
B. Decreased lean body mass and increased body fat, resulting in increased Vd of fat-soluble drugs
C. Increased or decreased free fraction of highly protein-bound drugs
D. All of these
Answer:D
Geriatric patients may have following distribution effects?
A. Decreased total body water, resulting in decreased volume of distribution (Va) of water-soluble drugs (increased serum concentrations) B. Decreased lean body mass and increased body fat, resulting in increased Vd of fat-soluble drugs C. Increased or decreased free fraction of highly protein-bound drugs D. All of these