<p><b>15號染色體</b>是人類23對染色體中的一對，正常人擁有2條15號染色體。15號染色體纏繞了約1億100萬鹼基對（構築DNA的材料），並包含了人類細胞中約3%至3.5%的DNA。每條染色體上的基因識別是遺傳研究活躍的領域。因為研究人員使用不同的方法來進行對於每一條染色體基因數目的預測，而基因數目的估計會有所變化。15號染色體的基因數目有可能介於700個至900個。
</p>


<h2><span id=".E5.9F.BA.E5.9B.A0.E7.B5.84.E6.88.90"></span><span id="基因組成">基因組成</span></h2>
<p><b>15號染色體</b>基因組成有CAPN3、CHP、FAH、FBN1、HEXA、IVD、MCPH4、OCA2、RAD51、STRC、UBE3A、PML、SLC24A5等等，詳細基因組成的介紹請參見英文版本的維基百科。
</p>
<h2><span id=".E5.8F.83.E8.80.83.E8.B3.87.E6.96.99"></span><span id="參考資料">參考資料</span></h2>

<h3><span id=".E5.85.B6.E4.BB.96"></span><span id="其他">其他</span></h3>
<ul><li><cite class="citation journal">Bittel DC, Butler MG. Prader-Willi syndrome: clinical genetics, cytogenetics and molecular biology. Expert Rev Mol Med. 2005, <b>7</b> (14): 1–20. <span title="公共醫學識別碼">PMID 16038620</span>. <span title="數位物件識別號">doi:10.1017/S1462399405009531</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Prader-Willi+syndrome%3A+clinical+genetics%2C+cytogenetics+and+molecular+biology&amp;rft.au=Bittel+DC%2C+Butler+MG&amp;rft.date=2005&amp;rft.genre=article&amp;rft.issue=14&amp;rft.jtitle=Expert+Rev+Mol+Med&amp;rft.pages=1-20&amp;rft.volume=7&amp;rft_id=info%3Adoi%2F10.1017%2FS1462399405009531&amp;rft_id=info%3Apmid%2F16038620&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. J Med Genet. 2003, <b>40</b> (8): 568–574. <span><span title="公共醫學中心">PMC 1735542</span> </span>. <span title="公共醫學識別碼">PMID 12920063</span>. <span title="數位物件識別號">doi:10.1136/jmg.40.8.568</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Microarray+analysis+of+gene%2Ftranscript+expression+in+Prader-Willi+syndrome%3A+deletion+versus+UPD&amp;rft.au=Bittel+DC%2C+Kibiryeva+N%2C+Talebizadeh+Z%2C+Butler+MG&amp;rft.date=2003&amp;rft.genre=article&amp;rft.issue=8&amp;rft.jtitle=J+Med+Genet&amp;rft.pages=568-574&amp;rft.volume=40&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1735542&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-medical-genetics_2003-08_40_8%2Fpage%2F568&amp;rft_id=info%3Adoi%2F10.1136%2Fjmg.40.8.568&amp;rft_id=info%3Apmid%2F12920063&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Bittel DC, Kibiryeva N, Talebizadeh Z, Driscoll DJ, Butler MG. Microarray analysis of gene/transcript expression in Angelman syndrome: deletion versus UPD. Genomics. 2005, <b>85</b> (1): 85–91. <span title="公共醫學識別碼">PMID 15607424</span>. <span title="數位物件識別號">doi:10.1016/j.ygeno.2004.10.010</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Microarray+analysis+of+gene%2Ftranscript+expression+in+Angelman+syndrome%3A+deletion+versus+UPD&amp;rft.au=Bittel+DC%2C+Kibiryeva+N%2C+Talebizadeh+Z%2C+Driscoll+DJ%2C+Butler+MG&amp;rft.date=2005&amp;rft.genre=article&amp;rft.issue=1&amp;rft.jtitle=Genomics&amp;rft.pages=85-91&amp;rft.volume=85&amp;rft_id=info%3Adoi%2F10.1016%2Fj.ygeno.2004.10.010&amp;rft_id=info%3Apmid%2F15607424&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Borgatti R, Piccinelli P, Passoni D, Dalpra L, Miozzo M, Micheli R, Gagliardi C, Balottin U. Relationship between clinical and genetic features in "inverted duplicated chromosome 15" patients. Pediatr Neurol. 2001, <b>24</b> (2): 111–116. <span title="公共醫學識別碼">PMID 11275459</span>. <span title="數位物件識別號">doi:10.1016/S0887-8994(00)00244-7</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Relationship+between+clinical+and+genetic+features+in+%22inverted+duplicated+chromosome+15%22+patients&amp;rft.au=Borgatti+R%2C+Piccinelli+P%2C+Passoni+D%2C+Dalpra+L%2C+Miozzo+M%2C+Micheli+R%2C+Gagliardi+C%2C+Balottin+U&amp;rft.date=2001&amp;rft.genre=article&amp;rft.issue=2&amp;rft.jtitle=Pediatr+Neurol&amp;rft.pages=111-116&amp;rft.volume=24&amp;rft_id=info%3Adoi%2F10.1016%2FS0887-8994%2800%2900244-7&amp;rft_id=info%3Apmid%2F11275459&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Butler MG, Bittel DC, Kibiryeva N, Talebizadeh Z, Thompson T. Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy. Pediatrics. 2004, <b>113</b> (3 Pt 1): 565–573. <span title="公共醫學識別碼">PMID 14993551</span>. <span title="數位物件識別號">doi:10.1542/peds.113.3.565</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Behavioral+differences+among+subjects+with+Prader-Willi+syndrome+and+type+I+or+type+II+deletion+and+maternal+disomy&amp;rft.au=Butler+MG%2C+Bittel+DC%2C+Kibiryeva+N%2C+Talebizadeh+Z%2C+Thompson+T&amp;rft.date=2004&amp;rft.genre=article&amp;rft.issue=3+Pt+1&amp;rft.jtitle=Pediatrics&amp;rft.pages=565-573&amp;rft.volume=113&amp;rft_id=info%3Adoi%2F10.1542%2Fpeds.113.3.565&amp;rft_id=info%3Apmid%2F14993551&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Cassidy SB, Dykens E, Williams CA. Prader-Willi and Angelman syndromes: sister imprinted disorders. Am J Med Genet. 2000, <b>97</b> (2): 136–146. <span title="公共醫學識別碼">PMID 11180221</span>. <span title="數位物件識別號">doi:10.1002/1096-8628(200022)97:2&lt;136::AID-AJMG5&gt;3.0.CO;2-V</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Prader-Willi+and+Angelman+syndromes%3A+sister+imprinted+disorders&amp;rft.au=Cassidy+SB%2C+Dykens+E%2C+Williams+CA&amp;rft.date=2000&amp;rft.genre=article&amp;rft.issue=2&amp;rft.jtitle=Am+J+Med+Genet&amp;rft.pages=136-146&amp;rft.volume=97&amp;rft_id=info%3Adoi%2F10.1002%2F1096-8628%28200022%2997%3A2%3C136%3A%3AAID-AJMG5%3E3.0.CO%3B2-V&amp;rft_id=info%3Apmid%2F11180221&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Clayton-Smith J, Laan L. Angelman syndrome: a review of the clinical and genetic aspects. J Med Genet. 2003, <b>40</b> (2): 87–95. <span><span title="公共醫學中心">PMC 1735357</span> </span>. <span title="公共醫學識別碼">PMID 12566516</span>. <span title="數位物件識別號">doi:10.1136/jmg.40.2.87</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Angelman+syndrome%3A+a+review+of+the+clinical+and+genetic+aspects&amp;rft.au=Clayton-Smith+J%2C+Laan+L&amp;rft.date=2003&amp;rft.genre=article&amp;rft.issue=2&amp;rft.jtitle=J+Med+Genet&amp;rft.pages=87-95&amp;rft.volume=40&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1735357&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_journal-of-medical-genetics_2003-02_40_2%2Fpage%2F87&amp;rft_id=info%3Adoi%2F10.1136%2Fjmg.40.2.87&amp;rft_id=info%3Apmid%2F12566516&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Gilbert F. Disease genes and chromosomes: disease maps of the human genome. Chromosome 15. Genet Test. 1999, <b>3</b> (3): 309–322. <span title="公共醫學識別碼">PMID 10495933</span>. <span title="數位物件識別號">doi:10.1089/109065799316653</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Disease+genes+and+chromosomes%3A+disease+maps+of+the+human+genome.+Chromosome+15&amp;rft.au=Gilbert+F&amp;rft.date=1999&amp;rft.genre=article&amp;rft.issue=3&amp;rft.jtitle=Genet+Test&amp;rft.pages=309-322&amp;rft.volume=3&amp;rft_id=info%3Adoi%2F10.1089%2F109065799316653&amp;rft_id=info%3Apmid%2F10495933&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Lee S, Wevrick R. Identification of novel imprinted transcripts in the Prader-Willi syndrome and Angelman syndrome deletion region: further evidence for regional imprinting control. Am J Hum Genet. 2000, <b>66</b> (3): 848–858. <span><span title="公共醫學中心">PMC 1288168</span> </span>. <span title="公共醫學識別碼">PMID 10712201</span>. <span title="數位物件識別號">doi:10.1086/302817</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Identification+of+novel+imprinted+transcripts+in+the+Prader-Willi+syndrome+and+Angelman+syndrome+deletion+region%3A+further+evidence+for+regional+imprinting+control&amp;rft.au=Lee+S%2C+Wevrick+R&amp;rft.date=2000&amp;rft.genre=article&amp;rft.issue=3&amp;rft.jtitle=Am+J+Hum+Genet&amp;rft.pages=848-858&amp;rft.volume=66&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC1288168&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_american-journal-of-human-genetics_2000-03_66_3%2Fpage%2F848&amp;rft_id=info%3Adoi%2F10.1086%2F302817&amp;rft_id=info%3Apmid%2F10712201&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Rineer S, Finucane B, Simon EW. Autistic symptoms among children and young adults with isodicentric chromosome 15. Am J Med Genet. 1998, <b>81</b> (5): 428–433. <span title="公共醫學識別碼">PMID 9754629</span>. <span title="數位物件識別號">doi:10.1002/(SICI)1096-8628(19980907)81:5&lt;428::AID-AJMG12&gt;3.0.CO;2-E</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Autistic+symptoms+among+children+and+young+adults+with+isodicentric+chromosome+15&amp;rft.au=Rineer+S%2C+Finucane+B%2C+Simon+EW&amp;rft.date=1998&amp;rft.genre=article&amp;rft.issue=5&amp;rft.jtitle=Am+J+Med+Genet&amp;rft.pages=428-433&amp;rft.volume=81&amp;rft_id=info%3Adoi%2F10.1002%2F%28SICI%291096-8628%2819980907%2981%3A5%3C428%3A%3AAID-AJMG12%3E3.0.CO%3B2-E&amp;rft_id=info%3Apmid%2F9754629&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Zollino M, Tiziano F, Di Stefano C, Neri G. Partial duplication of the long arm of chromosome 15: confirmation of a causative role in craniosynostosis and definition of a 15q25-qter trisomy syndrome. Am J Med Genet. 1999, <b>87</b> (5): 391–394. <span title="公共醫學識別碼">PMID 10594876</span>. <span title="數位物件識別號">doi:10.1002/(SICI)1096-8628(19991222)87:5&lt;391::AID-AJMG4&gt;3.0.CO;2-O</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A15%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Partial+duplication+of+the+long+arm+of+chromosome+15%3A+confirmation+of+a+causative+role+in+craniosynostosis+and+definition+of+a+15q25-qter+trisomy+syndrome&amp;rft.au=Zollino+M%2C+Tiziano+F%2C+Di+Stefano+C%2C+Neri+G&amp;rft.date=1999&amp;rft.genre=article&amp;rft.issue=5&amp;rft.jtitle=Am+J+Med+Genet&amp;rft.pages=391-394&amp;rft.volume=87&amp;rft_id=info%3Adoi%2F10.1002%2F%28SICI%291096-8628%2819991222%2987%3A5%3C391%3A%3AAID-AJMG4%3E3.0.CO%3B2-O&amp;rft_id=info%3Apmid%2F10594876&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li></ul><h2><span id=".E5.8F.83.E8.A6.8B"></span><span id="參見">參見</span></h2>
<ul><li>位於15號人類染色體的基因</li></ul><!-- 
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**15 號染色體**是人類 23 對染色體中的一對，正常人擁有 2 條 15 號染色體。15 號染色體纏繞了約 1 億 100 萬鹼基對（構築 DNA 的材料），並包含了人類細胞中約 3% 至 3.5% 的 DNA。每條染色體上的基因識別是遺傳研究活躍的領域。因為研究人員使用不同的方法來進行對於每一條染色體基因數目的預測，而基因數目的估計會有所變化。15 號染色體的基因數目有可能介於 700 個至 900 個。

## 基因組成

**15 號染色體**基因組成有 CAPN3、CHP、FAH、FBN1、HEXA、IVD、MCPH4、OCA2、RAD51、STRC、UBE3A、PML、SLC24A5 等等，詳細基因組成的介紹請參見英文版本的維基百科。

## 參考資料

### 其他

* Bittel DC, Butler MG. Prader-Willi syndrome: clinical genetics, cytogenetics and molecular biology. Expert Rev Mol Med. 2005, **7** (14): 1–20. PMID 16038620. doi:10.1017/S1462399405009531. （英文）
* Bittel DC, Kibiryeva N, Talebizadeh Z, Butler MG. Microarray analysis of gene/transcript expression in Prader-Willi syndrome: deletion versus UPD. J Med Genet. 2003, **40** (8): 568–574. PMC 1735542 . PMID 12920063. doi:10.1136/jmg.40.8.568. （英文）
* Bittel DC, Kibiryeva N, Talebizadeh Z, Driscoll DJ, Butler MG. Microarray analysis of gene/transcript expression in Angelman syndrome: deletion versus UPD. Genomics. 2005, **85** (1): 85–91. PMID 15607424. doi:10.1016/j.ygeno.2004.10.010. （英文）
* Borgatti R, Piccinelli P, Passoni D, Dalpra L, Miozzo M, Micheli R, Gagliardi C, Balottin U. Relationship between clinical and genetic features in "inverted duplicated chromosome 15" patients. Pediatr Neurol. 2001, **24** (2): 111–116. PMID 11275459. doi:10.1016/S0887-8994(00)00244-7. （英文）
* Butler MG, Bittel DC, Kibiryeva N, Talebizadeh Z, Thompson T. Behavioral differences among subjects with Prader-Willi syndrome and type I or type II deletion and maternal disomy. Pediatrics. 2004, **113** (3 Pt 1): 565–573. PMID 14993551. doi:10.1542/peds.113.3.565.
* Cassidy SB, Dykens E, Williams CA. Prader-Willi and Angelman syndromes: sister imprinted disorders. Am J Med Genet. 2000, **97** (2): 136–146. PMID 11180221. doi:10.1002/1096-8628(200022)97:2<136::AID-AJMG5>3.0.CO;2-V. （英文）
* Clayton-Smith J, Laan L. Angelman syndrome: a review of the clinical and genetic aspects. J Med Genet. 2003, **40** (2): 87–95. PMC 1735357 . PMID 12566516. doi:10.1136/jmg.40.2.87. （英文）
* Gilbert F. Disease genes and chromosomes: disease maps of the human genome. Chromosome 15. Genet Test. 1999, **3** (3): 309–322. PMID 10495933. doi:10.1089/109065799316653. （英文）
* Lee S, Wevrick R. Identification of novel imprinted transcripts in the Prader-Willi syndrome and Angelman syndrome deletion region: further evidence for regional imprinting control. Am J Hum Genet. 2000, **66** (3): 848–858. PMC 1288168 . PMID 10712201. doi:10.1086/302817. （英文）
* Rineer S, Finucane B, Simon EW. Autistic symptoms among children and young adults with isodicentric chromosome 15. Am J Med Genet. 1998, **81** (5): 428–433. PMID 9754629. doi:10.1002/(SICI)1096-8628(19980907)81:5<428::AID-AJMG12>3.0.CO;2-E. （英文）
* Zollino M, Tiziano F, Di Stefano C, Neri G. Partial duplication of the long arm of chromosome 15: confirmation of a causative role in craniosynostosis and definition of a 15q25-qter trisomy syndrome. Am J Med Genet. 1999, **87** (5): 391–394. PMID 10594876. doi:10.1002/(SICI)1096-8628(19991222)87:5<391::AID-AJMG4>3.0.CO;2-O. （英文）

## 參見

* 位於 15 號人類染色體的基因
15号染色体_(人类)