<p><b>13號染色體</b>是人類23對染色體中的一對，正常人擁有2條13號染色體。13號染色體纏繞了約1億1400萬鹼基對（構築DNA的材料），並包含了人類細胞中約3.5%至4%的DNA。每條染色體上的基因識別是遺傳研究活躍的領域。因為研究人員使用不同的方法來進行對於每一條染色體基因數目的預測，而基因數目的估計會有所變化。13號染色體的基因數目有可能介於300個至700個。
</p>


<h2><span id=".E7.96.BE.E7.97.85.E6.88.96.E7.97.87.E7.8B.80"></span><span id="疾病或症狀">疾病或症狀</span></h2>
<p>下列與13號人類染色體的基因異常有關的疾病或症狀：
</p>
<ul><li>三染色體13症</li>
<li>膀胱癌</li>
<li>乳癌</li>
<li>虹膜異色症</li>
<li>視網膜母細胞瘤</li>
<li>精神分裂症</li>
<li>瓦登伯革氏症候群</li>
<li>肝豆狀核變性</li></ul><h2><span id=".E5.8F.83.E8.80.83.E8.B3.87.E6.96.99"></span><span id="參考資料">參考資料</span></h2>

<h3><span id=".E5.85.B6.E4.BB.96"></span><span id="其他">其他</span></h3>
<ul><li><cite class="citation journal">Baud O, Cormier-Daire V, Lyonnet S, Desjardins L, Turleau C, Doz F. Dysmorphic phenotype and neurological impairment in 22 retinoblastoma patients with constitutional cytogenetic 13q deletion. Clin Genet. 1999, <b>55</b> (6): 478–82. <span title="公共醫學識別碼">PMID 10450867</span>. <span title="數位物件識別號">doi:10.1034/j.1399-0004.1999.550614.x</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A13%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Dysmorphic+phenotype+and+neurological+impairment+in+22+retinoblastoma+patients+with+constitutional+cytogenetic+13q+deletion&amp;rft.au=Baud+O%2C+Cormier-Daire+V%2C+Lyonnet+S%2C+Desjardins+L%2C+Turleau+C%2C+Doz+F&amp;rft.date=1999&amp;rft.genre=article&amp;rft.issue=6&amp;rft.jtitle=Clin+Genet&amp;rft.pages=478-82&amp;rft.volume=55&amp;rft_id=info%3Adoi%2F10.1034%2Fj.1399-0004.1999.550614.x&amp;rft_id=info%3Apmid%2F10450867&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT. The DNA sequence and analysis of human chromosome 13. Nature. 2004, <b>428</b> (6982): 522–8. <span><span title="公共醫學中心">PMC 2665288</span> </span>. <span title="公共醫學識別碼">PMID 15057823</span>. <span title="數位物件識別號">doi:10.1038/nature02379</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A13%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=The+DNA+sequence+and+analysis+of+human+chromosome+13&amp;rft.au=Dunham+A%2C+Matthews+LH%2C+Burton+J%2C+Ashurst+JL%2C+Howe+KL%2C+Ashcroft+KJ%2C+Beare+DM%2C+Burford+DC%2C+Hunt+SE%2C+Griffiths-Jones+S%2C+Jones+MC%2C+Keenan+SJ%2C+Oliver+K%2C+Scott+CE%2C+Ainscough+R%2C+Almeida+JP%2C+Ambrose+KD%2C+Andrews+DT%2C+Ashwell+RI%2C+Babbage+AK%2C+Bagguley+CL%2C+Bailey+J%2C+Bannerjee+R%2C+Barlow+KF%2C+Bates+K%2C+Beasley+H%2C+Bird+CP%2C+Bray-Allen+S%2C+Brown+AJ%2C+Brown+JY%2C+Burrill+W%2C+Carder+C%2C+Carter+NP%2C+Chapman+JC%2C+Clamp+ME%2C+Clark+SY%2C+Clarke+G%2C+Clee+CM%2C+Clegg+SC%2C+Cobley+V%2C+Collins+JE%2C+Corby+N%2C+Coville+GJ%2C+Deloukas+P%2C+Dhami+P%2C+Dunham+I%2C+Dunn+M%2C+Earthrowl+ME%2C+Ellington+AG%2C+Faulkner+L%2C+Frankish+AG%2C+Frankland+J%2C+French+L%2C+Garner+P%2C+Garnett+J%2C+Gilbert+JG%2C+Gilson+CJ%2C+Ghori+J%2C+Grafham+DV%2C+Gribble+SM%2C+Griffiths+C%2C+Hall+RE%2C+Hammond+S%2C+Harley+JL%2C+Hart+EA%2C+Heath+PD%2C+Howden+PJ%2C+Huckle+EJ%2C+Hunt+PJ%2C+Hunt+AR%2C+Johnson+C%2C+Johnson+D%2C+Kay+M%2C+Kimberley+AM%2C+King+A%2C+Laird+GK%2C+Langford+CJ%2C+Lawlor+S%2C+Leongamornlert+DA%2C+Lloyd+DM%2C+Lloyd+C%2C+Loveland+JE%2C+Lovell+J%2C+Martin+S%2C+Mashreghi-Mohammadi+M%2C+McLaren+SJ%2C+McMurray+A%2C+Milne+S%2C+Moore+MJ%2C+Nickerson+T%2C+Palmer+SA%2C+Pearce+AV%2C+Peck+AI%2C+Pelan+S%2C+Phillimore+B%2C+Porter+KM%2C+Rice+CM%2C+Searle+S%2C+Sehra+HK%2C+Shownkeen+R%2C+Skuce+CD%2C+Smith+M%2C+Steward+CA%2C+Sycamore+N%2C+Tester+J%2C+Thomas+DW%2C+Tracey+A%2C+Tromans+A%2C+Tubby+B%2C+Wall+M%2C+Wallis+JM%2C+West+AP%2C+Whitehead+SL%2C+Willey+DL%2C+Wilming+L%2C+Wray+PW%2C+Wright+MW%2C+Young+L%2C+Coulson+A%2C+Durbin+R%2C+Hubbard+T%2C+Sulston+JE%2C+Beck+S%2C+Bentley+DR%2C+Rogers+J%2C+Ross+MT&amp;rft.date=2004&amp;rft.genre=article&amp;rft.issue=6982&amp;rft.jtitle=Nature&amp;rft.pages=522-8&amp;rft.volume=428&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2665288&amp;rft_id=%2F%2Fwww.ncbi.nlm.nih.gov%2Fpmc%2Farticles%2FPMC2665288&amp;rft_id=info%3Adoi%2F10.1038%2Fnature02379&amp;rft_id=info%3Apmid%2F15057823&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Gilbert F. Chromosome 13. Genet Test. 2000, <b>4</b> (1): 85–94. <span title="公共醫學識別碼">PMID 10794368</span>. <span title="數位物件識別號">doi:10.1089/109065700316543</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A13%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Chromosome+13&amp;rft.au=Gilbert+F&amp;rft.date=2000&amp;rft.genre=article&amp;rft.issue=1&amp;rft.jtitle=Genet+Test&amp;rft.pages=85-94&amp;rft.volume=4&amp;rft_id=info%3Adoi%2F10.1089%2F109065700316543&amp;rft_id=info%3Apmid%2F10794368&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li>
<li><cite class="citation journal">Kivela T, Tuppurainen K, Riikonen P, Vapalahti M. Retinoblastoma associated with chromosomal 13q14 deletion mosaicism. Ophthalmology. 2003, <b>110</b> (10): 1983–8. <span title="公共醫學識別碼">PMID 14522775</span>. <span title="數位物件識別號">doi:10.1016/S0161-6420(03)00484-6</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A13%E5%8F%B7%E6%9F%93%E8%89%B2%E4%BD%93&amp;rft.atitle=Retinoblastoma+associated+with+chromosomal+13q14+deletion+mosaicism&amp;rft.au=Kivela+T%2C+Tuppurainen+K%2C+Riikonen+P%2C+Vapalahti+M&amp;rft.date=2003&amp;rft.genre=article&amp;rft.issue=10&amp;rft.jtitle=Ophthalmology&amp;rft.pages=1983-8&amp;rft.volume=110&amp;rft_id=https%3A%2F%2Farchive.org%2Fdetails%2Fsim_ophthalmology_2003-10_110_10%2Fpage%2F1983&amp;rft_id=info%3Adoi%2F10.1016%2FS0161-6420%2803%2900484-6&amp;rft_id=info%3Apmid%2F14522775&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span><span title="英語">（英文）</span></li></ul><h2><span id=".E5.8F.83.E8.A6.8B"></span><span id="參見">參見</span></h2>
<ul><li>位於13號人類染色體的基因</li></ul><!-- 
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**13 號染色體**是人類 23 對染色體中的一對，正常人擁有 2 條 13 號染色體。13 號染色體纏繞了約 1 億 1400 萬鹼基對（構築 DNA 的材料），並包含了人類細胞中約 3.5% 至 4% 的 DNA。每條染色體上的基因識別是遺傳研究活躍的領域。因為研究人員使用不同的方法來進行對於每一條染色體基因數目的預測，而基因數目的估計會有所變化。13 號染色體的基因數目有可能介於 300 個至 700 個。

## 疾病或症狀

下列與 13 號人類染色體的基因異常有關的疾病或症狀：

* 三染色體 13 症
* 膀胱癌
* 乳癌
* 虹膜異色症
* 視網膜母細胞瘤
* 精神分裂症
* 瓦登伯革氏症候群
* 肝豆狀核變性

## 參考資料

### 其他

* Baud O, Cormier-Daire V, Lyonnet S, Desjardins L, Turleau C, Doz F. Dysmorphic phenotype and neurological impairment in 22 retinoblastoma patients with constitutional cytogenetic 13q deletion. Clin Genet. 1999, **55** (6): 478–82. PMID 10450867. doi:10.1034/j.1399-0004.1999.550614.x. （英文）
* Dunham A, Matthews LH, Burton J, Ashurst JL, Howe KL, Ashcroft KJ, Beare DM, Burford DC, Hunt SE, Griffiths-Jones S, Jones MC, Keenan SJ, Oliver K, Scott CE, Ainscough R, Almeida JP, Ambrose KD, Andrews DT, Ashwell RI, Babbage AK, Bagguley CL, Bailey J, Bannerjee R, Barlow KF, Bates K, Beasley H, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burrill W, Carder C, Carter NP, Chapman JC, Clamp ME, Clark SY, Clarke G, Clee CM, Clegg SC, Cobley V, Collins JE, Corby N, Coville GJ, Deloukas P, Dhami P, Dunham I, Dunn M, Earthrowl ME, Ellington AG, Faulkner L, Frankish AG, Frankland J, French L, Garner P, Garnett J, Gilbert JG, Gilson CJ, Ghori J, Grafham DV, Gribble SM, Griffiths C, Hall RE, Hammond S, Harley JL, Hart EA, Heath PD, Howden PJ, Huckle EJ, Hunt PJ, Hunt AR, Johnson C, Johnson D, Kay M, Kimberley AM, King A, Laird GK, Langford CJ, Lawlor S, Leongamornlert DA, Lloyd DM, Lloyd C, Loveland JE, Lovell J, Martin S, Mashreghi-Mohammadi M, McLaren SJ, McMurray A, Milne S, Moore MJ, Nickerson T, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter KM, Rice CM, Searle S, Sehra HK, Shownkeen R, Skuce CD, Smith M, Steward CA, Sycamore N, Tester J, Thomas DW, Tracey A, Tromans A, Tubby B, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Wilming L, Wray PW, Wright MW, Young L, Coulson A, Durbin R, Hubbard T, Sulston JE, Beck S, Bentley DR, Rogers J, Ross MT. The DNA sequence and analysis of human chromosome 13. Nature. 2004, **428** (6982): 522–8. PMC 2665288 . PMID 15057823. doi:10.1038/nature02379. （英文）
* Gilbert F. Chromosome 13. Genet Test. 2000, **4** (1): 85–94. PMID 10794368. doi:10.1089/109065700316543. （英文）
* Kivela T, Tuppurainen K, Riikonen P, Vapalahti M. Retinoblastoma associated with chromosomal 13q14 deletion mosaicism. Ophthalmology. 2003, **110** (10): 1983–8. PMID 14522775. doi:10.1016/S0161-6420(03)00484-6. （英文）

## 參見

* 位於 13 號人類染色體的基因
13号染色体