<p><b>1,4,7,10-四氮雜環十二烷</b>是一種<span data-orig-title="氮杂冠醚" data-lang-code="en" data-lang-name="英語" data-foreign-title="aza-crown ether"><span>氮雜冠醚</span></span>，化學式為(CH<sub>2</sub>CH<sub>2</sub>NH)<sub>4</sub>，它是白色固體。
</p>


<h2><span id=".E5.90.88.E6.88.90"></span><span id="合成">合成</span></h2>
<p>1,4,7,10-四氮雜環十二烷可以通過兩步的親核取代反應製得。該反應需要很稀的反應物濃度，否則會聚合為長鏈化合物而非環狀化合物。反應結束後，Ts基團可由硫酸脫去。
</p>
<dl><dd></dd></dl><p>另一種方法是以<span data-orig-title="三乙烯四胺" data-lang-code="en" data-lang-name="英語" data-foreign-title="triethylenetetraamine"><span>三乙烯四胺</span></span>和二硫代草醯胺為原料反應，經DIBAL還原、擴環，得到產物。</p>
<dl><dd></dd></dl><h2><span id=".E5.8F.82.E8.A7.81"></span><span id="参见">參見</span></h2>
<ul><li>1,4,8,11-四氮雜環十四烷</li></ul><h2><span id=".E5.8F.82.E8.80.83.E6.96.87.E7.8C.AE"></span><span id="参考文献">參考文獻</span></h2>

<h2><span id=".E6.8B.93.E5.B1.95.E9.98.85.E8.AF.BB"></span><span id="拓展阅读">拓展閱讀</span></h2>
<ul><li><cite class="citation journal">Suchý, M.; Hudson, R. H. E. Synthetic Strategies Toward <i>N</i>-Functionalized Cyclens. <span data-orig-title="Eur. J. Org. Chem." data-lang-code="en" data-lang-name="英語" data-foreign-title="Eur. J. Org. Chem."><span>Eur. J. Org. Chem.</span></span>. 2008, <b>2008</b> (29): 4847–4865. <span title="數位物件識別號">doi:10.1002/ejoc.200800636</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A1%2C4%2C7%2C10-%E5%9B%9B%E6%B0%AE%E6%9D%82%E7%8E%AF%E5%8D%81%E4%BA%8C%E7%83%B7&amp;rft.atitle=Synthetic+Strategies+Toward+N-Functionalized+Cyclens&amp;rft.au=Hudson%2C+R.+H.+E.&amp;rft.au=Such%C3%BD%2C+M.&amp;rft.date=2008&amp;rft.genre=article&amp;rft.issue=29&amp;rft.jtitle=%3Cspan+class%3D%22ilh-all+%22+data-orig-title%3D%22Eur.+J.+Org.+Chem.%22+data-lang-code%3D%22en%22+data-lang-name%3D%22%E8%8B%B1%E8%AA%9E%22+data-foreign-title%3D%22Eur.+J.+Org.+Chem.%22%3E%3Cspan+class%3D%22ilh-page%22%3EEur.+J.+Org.+Chem.%3C%2Fspan%3E%3Cspan+class%3D%22noprint+ilh-comment%22%3E%EF%BC%88%3Cspan+class%3D%22ilh-lang%22%3E%E8%8B%B1%E8%AA%9E%3C%2Fspan%3E%3Cspan+class%3D%22ilh-colon%22%3E%EF%BC%9A%3C%2Fspan%3E%3Cspan+class%3D%22ilh-link%22%3E-%7B%3Cspan+lang%3D%22en%22+dir%3D%22auto%22%3EEur.+J.+Org.+Chem.%3C%2Fspan%3E%7D-%3C%2Fspan%3E%EF%BC%89%3C%2Fspan%3E%3C%2Fspan%3E&amp;rft.pages=4847-4865&amp;rft.volume=2008&amp;rft_id=info%3Adoi%2F10.1002%2Fejoc.200800636&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li></ul><!-- 
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**1,4,7,10 - 四氮雜環十二烷**是一種氮雜冠醚，化學式為 (CH2CH2NH)4，它是白色固體。

## 合成

1,4,7,10 - 四氮雜環十二烷可以通過兩步的親核取代反應製得。該反應需要很稀的反應物濃度，否則會聚合為長鏈化合物而非環狀化合物。反應結束後，Ts 基團可由硫酸脫去。

　
:

另一種方法是以三乙烯四胺和二硫代草醯胺為原料反應，經 DIBAL 還原、擴環，得到產物。

　
:

## 參見

* 1,4,8,11 - 四氮雜環十四烷

## 參考文獻

## 拓展閱讀

* Suchý, M.; Hudson, R. H. E. Synthetic Strategies Toward _N_-Functionalized Cyclens. Eur. J. Org. Chem.. 2008, **2008** (29): 4847–4865. doi:10.1002/ejoc.200800636.
1,4,7,10-四氮杂环十二烷