<p><b>達那唑</b>（Danazol）為一種用於治療子宮內膜異位症、乳腺小葉增生、<span data-orig-title="遺傳性血管性水腫" data-lang-code="en" data-lang-name="英語" data-foreign-title="hereditary angioedema"><span>遺傳性血管性水腫</span></span>及其他疾病的藥物，主要經口服給藥。
</p><p>達那唑具有雄性化的副作用，使其用途大受限制。常見不良反應包含痤瘡、多毛症，以及聲音變低沉。達那唑的作用機轉複雜，同時具有弱雄激素、弱同化類固醇、弱孕激素，弱<span data-orig-title="抗促性腺激素" data-lang-code="en" data-lang-name="英語" data-foreign-title="Antigonadotropin"><span>抗促性腺激素</span></span>、弱<span data-orig-title="固醇類合成抑制劑" data-lang-code="en" data-lang-name="英語" data-foreign-title="steroidogenesis inhibitor"><span>固醇類合成抑制劑</span></span>，以及功能性<span data-orig-title="抗動情素藥物" data-lang-code="en" data-lang-name="英語" data-foreign-title="Antiestrogen"><span>抗動情素藥物</span></span>。
</p><p>達那唑發現於1963年，並於1971年應用於醫學。隨著副作用更少的<span data-orig-title="性腺激素釋放素類似物" data-lang-code="en" data-lang-name="英語" data-foreign-title="gonadotropin-releasing hormone analogue"><span>性腺激素釋放素類似物</span></span>應用逐漸廣泛，達那唑在治療子宮內膜異位症的角色已被前者所取代。
</p>
<h2><span id=".E5.8F.83.E8.80.83.E6.96.87.E7.8D.BB"></span><span id="參考文獻">參考文獻</span></h2>

<h2><span id=".E5.BB.B6.E4.BC.B8.E9.96.B1.E8.AE.80"></span><span id="延伸閱讀">延伸閱讀</span></h2>
<ul><li><cite class="citation journal">Dmowski WP. Endocrine properties and clinical application of danazol. Fertil. Steril. March 1979, <b>31</b> (3): 237–51. <span title="公共醫學識別碼">PMID 374128</span>. <span title="數位物件識別號">doi:10.1016/S0015-0282(16)43869-0</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Endocrine+properties+and+clinical+application+of+danazol&amp;rft.aufirst=WP&amp;rft.aulast=Dmowski&amp;rft.date=1979-03&amp;rft.genre=article&amp;rft.issue=3&amp;rft.jtitle=Fertil.+Steril.&amp;rft.pages=237-51&amp;rft.volume=31&amp;rft_id=info%3Adoi%2F10.1016%2FS0015-0282%2816%2943869-0&amp;rft_id=info%3Apmid%2F374128&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Fraser IS. Danazol--a steroid with a unique combination of actions. Scott Med J. April 1979, <b>24</b> (2): 147–50. <span title="公共醫學識別碼">PMID 386503</span>. <span title="數位物件識別號">doi:10.1177/003693307902400209</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol--a+steroid+with+a+unique+combination+of+actions&amp;rft.aufirst=IS&amp;rft.aulast=Fraser&amp;rft.date=1979-04&amp;rft.genre=article&amp;rft.issue=2&amp;rft.jtitle=Scott+Med+J&amp;rft.pages=147-50&amp;rft.volume=24&amp;rft_id=info%3Adoi%2F10.1177%2F003693307902400209&amp;rft_id=info%3Apmid%2F386503&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Potts GO, Schane HP, Edelson J. Pharmacology and pharmacokinetics of danazol. Drugs. May 1980, <b>19</b> (5): 321–30. <span title="公共醫學識別碼">PMID 6993179</span>. <span title="數位物件識別號">doi:10.2165/00003495-198019050-00001</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Pharmacology+and+pharmacokinetics+of+danazol&amp;rft.au=Edelson%2C+J&amp;rft.au=Schane%2C+HP&amp;rft.aufirst=GO&amp;rft.aulast=Potts&amp;rft.date=1980-05&amp;rft.genre=article&amp;rft.issue=5&amp;rft.jtitle=Drugs&amp;rft.pages=321-30&amp;rft.volume=19&amp;rft_id=info%3Adoi%2F10.2165%2F00003495-198019050-00001&amp;rft_id=info%3Apmid%2F6993179&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Jenkin G. Review: The mechanism of action of danazol, a novel steroid derivative. Aust N Z J Obstet Gynaecol. May 1980, <b>20</b> (2): 113–8. <span title="公共醫學識別碼">PMID 6998453</span>. <span title="數位物件識別號">doi:10.1111/j.1479-828X.1980.tb00107.x</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Review%3A+The+mechanism+of+action+of+danazol%2C+a+novel+steroid+derivative&amp;rft.aufirst=G&amp;rft.aulast=Jenkin&amp;rft.date=1980-05&amp;rft.genre=article&amp;rft.issue=2&amp;rft.jtitle=Aust+N+Z+J+Obstet+Gynaecol&amp;rft.pages=113-8&amp;rft.volume=20&amp;rft_id=info%3Adoi%2F10.1111%2Fj.1479-828X.1980.tb00107.x&amp;rft_id=info%3Apmid%2F6998453&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Barbieri RL, Ryan KJ. Danazol: endocrine pharmacology and therapeutic applications. Am. J. Obstet. Gynecol. October 1981, <b>141</b> (4): 453–63. <span title="公共醫學識別碼">PMID 7025640</span>. <span title="數位物件識別號">doi:10.1016/0002-9378(81)90611-6</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol%3A+endocrine+pharmacology+and+therapeutic+applications&amp;rft.au=Ryan%2C+KJ&amp;rft.aufirst=RL&amp;rft.aulast=Barbieri&amp;rft.date=1981-10&amp;rft.genre=article&amp;rft.issue=4&amp;rft.jtitle=Am.+J.+Obstet.+Gynecol.&amp;rft.pages=453-63&amp;rft.volume=141&amp;rft_id=info%3Adoi%2F10.1016%2F0002-9378%2881%2990611-6&amp;rft_id=info%3Apmid%2F7025640&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Dmowski WP. Danazol. A synthetic steroid with diverse biologic effects. J Reprod Med. January 1990, <b>35</b> (1 Suppl): 69–74; discussion 74–5. <span title="公共醫學識別碼">PMID 2404115</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol.+A+synthetic+steroid+with+diverse+biologic+effects&amp;rft.aufirst=WP&amp;rft.aulast=Dmowski&amp;rft.date=1990-01&amp;rft.genre=article&amp;rft.issue=1+Suppl&amp;rft.jtitle=J+Reprod+Med&amp;rft.pages=69-74%3B+discussion+74-5&amp;rft.volume=35&amp;rft_id=info%3Apmid%2F2404115&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Barbieri RL. Danazol: molecular, endocrine, and clinical pharmacology. Prog. Clin. Biol. Res. 1990, <b>323</b>: 241–52. <span title="公共醫學識別碼">PMID 2406750</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol%3A+molecular%2C+endocrine%2C+and+clinical+pharmacology&amp;rft.aufirst=RL&amp;rft.aulast=Barbieri&amp;rft.date=1990&amp;rft.genre=article&amp;rft.jtitle=Prog.+Clin.+Biol.+Res.&amp;rft.pages=241-52&amp;rft.volume=323&amp;rft_id=info%3Apmid%2F2406750&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Hughes E, Brown J, Tiffin G, Vandekerckhove P. Danazol for unexplained subfertility. Cochrane Database Syst Rev. January 2007, (1): CD000069. <span title="公共醫學識別碼">PMID 17253444</span>. <span title="數位物件識別號">doi:10.1002/14651858.CD000069.pub2</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol+for+unexplained+subfertility&amp;rft.au=Brown%2C+J&amp;rft.au=Tiffin%2C+G&amp;rft.au=Vandekerckhove%2C+P&amp;rft.aufirst=E&amp;rft.aulast=Hughes&amp;rft.date=2007-01&amp;rft.genre=article&amp;rft.issue=1&amp;rft.jtitle=Cochrane+Database+Syst+Rev&amp;rft.pages=CD000069&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD000069.pub2&amp;rft_id=info%3Apmid%2F17253444&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Beaumont H, Augood C, Duckitt K, Lethaby A. Danazol for heavy menstrual bleeding. Cochrane Database Syst Rev. July 2007, (3): CD001017. <span title="公共醫學識別碼">PMID 17636649</span>. <span title="數位物件識別號">doi:10.1002/14651858.CD001017.pub2</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol+for+heavy+menstrual+bleeding&amp;rft.au=Augood%2C+C&amp;rft.au=Duckitt%2C+K&amp;rft.au=Lethaby%2C+A&amp;rft.aufirst=H&amp;rft.aulast=Beaumont&amp;rft.date=2007-07&amp;rft.genre=article&amp;rft.issue=3&amp;rft.jtitle=Cochrane+Database+Syst+Rev&amp;rft.pages=CD001017&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD001017.pub2&amp;rft_id=info%3Apmid%2F17636649&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Selak V, Farquhar C, Prentice A, Singla A. Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. October 2007, (4): CD000068. <span title="公共醫學識別碼">PMID 17943735</span>. <span title="數位物件識別號">doi:10.1002/14651858.CD000068.pub2</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol+for+pelvic+pain+associated+with+endometriosis&amp;rft.au=Farquhar%2C+C&amp;rft.au=Prentice%2C+A&amp;rft.au=Singla%2C+A&amp;rft.aufirst=V&amp;rft.aulast=Selak&amp;rft.date=2007-10&amp;rft.genre=article&amp;rft.issue=4&amp;rft.jtitle=Cochrane+Database+Syst+Rev&amp;rft.pages=CD000068&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD000068.pub2&amp;rft_id=info%3Apmid%2F17943735&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Craig TJ. Appraisal of danazol prophylaxis for hereditary angioedema. Allergy Asthma Proc. 2008, <b>29</b> (3): 225–31. <span title="公共醫學識別碼">PMID 18387221</span>. <span title="數位物件識別號">doi:10.2500/aap.2008.29.3107</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Appraisal+of+danazol+prophylaxis+for+hereditary+angioedema&amp;rft.aufirst=TJ&amp;rft.aulast=Craig&amp;rft.date=2008&amp;rft.genre=article&amp;rft.issue=3&amp;rft.jtitle=Allergy+Asthma+Proc&amp;rft.pages=225-31&amp;rft.volume=29&amp;rft_id=info%3Adoi%2F10.2500%2Faap.2008.29.3107&amp;rft_id=info%3Apmid%2F18387221&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Ke LQ, Yang K, Li J, Li CM. Danazol for uterine fibroids. Cochrane Database Syst Rev. July 2009, (3): CD007692. <span title="公共醫學識別碼">PMID 19588442</span>. <span title="數位物件識別號">doi:10.1002/14651858.CD007692.pub2</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol+for+uterine+fibroids&amp;rft.au=Li%2C+CM&amp;rft.au=Li%2C+J&amp;rft.au=Yang%2C+K&amp;rft.aufirst=LQ&amp;rft.aulast=Ke&amp;rft.date=2009-07&amp;rft.genre=article&amp;rft.issue=3&amp;rft.jtitle=Cochrane+Database+Syst+Rev&amp;rft.pages=CD007692&amp;rft_id=info%3Adoi%2F10.1002%2F14651858.CD007692.pub2&amp;rft_id=info%3Apmid%2F19588442&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li>
<li><cite class="citation journal">Letchumanan P, Thumboo J. Danazol in the treatment of systemic lupus erythematosus: a qualitative systematic review. Semin. Arthritis Rheum. February 2011, <b>40</b> (4): 298–306. <span title="公共醫學識別碼">PMID 20541792</span>. <span title="數位物件識別號">doi:10.1016/j.semarthrit.2010.03.005</span>.</cite><span title="ctx_ver=Z39.88-2004&amp;rfr_id=info%3Asid%2Fzh.wikipedia.org%3A%E9%81%94%E9%82%A3%E5%94%91&amp;rft.atitle=Danazol+in+the+treatment+of+systemic+lupus+erythematosus%3A+a+qualitative+systematic+review&amp;rft.au=Thumboo%2C+J&amp;rft.aufirst=P&amp;rft.aulast=Letchumanan&amp;rft.date=2011-02&amp;rft.genre=article&amp;rft.issue=4&amp;rft.jtitle=Semin.+Arthritis+Rheum.&amp;rft.pages=298-306&amp;rft.volume=40&amp;rft_id=info%3Adoi%2F10.1016%2Fj.semarthrit.2010.03.005&amp;rft_id=info%3Apmid%2F20541792&amp;rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal"><span> </span></span></li></ul><p><br></p>
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**達那唑**（Danazol）為一種用於治療子宮內膜異位症、乳腺小葉增生、遺傳性血管性水腫及其他疾病的藥物，主要經口服給藥。

達那唑具有雄性化的副作用，使其用途大受限制。常見不良反應包含痤瘡、多毛症，以及聲音變低沉。達那唑的作用機轉複雜，同時具有弱雄激素、弱同化類固醇、弱孕激素，弱抗促性腺激素、弱固醇類合成抑制劑，以及功能性抗動情素藥物。

達那唑發現於 1963 年，並於 1971 年應用於醫學。隨著副作用更少的性腺激素釋放素類似物應用逐漸廣泛，達那唑在治療子宮內膜異位症的角色已被前者所取代。

## 參考文獻

## 延伸閱讀

* Dmowski WP. Endocrine properties and clinical application of danazol. Fertil. Steril. March 1979, **31** (3): 237–51. PMID 374128. doi:10.1016/S0015-0282(16)43869-0.
* Fraser IS. Danazol--a steroid with a unique combination of actions. Scott Med J. April 1979, **24** (2): 147–50. PMID 386503. doi:10.1177/003693307902400209.
* Potts GO, Schane HP, Edelson J. Pharmacology and pharmacokinetics of danazol. Drugs. May 1980, **19** (5): 321–30. PMID 6993179. doi:10.2165/00003495-198019050-00001.
* Jenkin G. Review: The mechanism of action of danazol, a novel steroid derivative. Aust N Z J Obstet Gynaecol. May 1980, **20** (2): 113–8. PMID 6998453. doi:10.1111/j.1479-828X.1980.tb00107.x.
* Barbieri RL, Ryan KJ. Danazol: endocrine pharmacology and therapeutic applications. Am. J. Obstet. Gynecol. October 1981, **141** (4): 453–63. PMID 7025640. doi:10.1016/0002-9378(81)90611-6.
* Dmowski WP. Danazol. A synthetic steroid with diverse biologic effects. J Reprod Med. January 1990, **35** (1 Suppl): 69–74; discussion 74–5. PMID 2404115.
* Barbieri RL. Danazol: molecular, endocrine, and clinical pharmacology. Prog. Clin. Biol. Res. 1990, **323**: 241–52. PMID 2406750.
* Hughes E, Brown J, Tiffin G, Vandekerckhove P. Danazol for unexplained subfertility. Cochrane Database Syst Rev. January 2007, (1): CD000069. PMID 17253444. doi:10.1002/14651858.CD000069.pub2.
* Beaumont H, Augood C, Duckitt K, Lethaby A. Danazol for heavy menstrual bleeding. Cochrane Database Syst Rev. July 2007, (3): CD001017. PMID 17636649. doi:10.1002/14651858.CD001017.pub2.
* Selak V, Farquhar C, Prentice A, Singla A. Danazol for pelvic pain associated with endometriosis. Cochrane Database Syst Rev. October 2007, (4): CD000068. PMID 17943735. doi:10.1002/14651858.CD000068.pub2.
* Craig TJ. Appraisal of danazol prophylaxis for hereditary angioedema. Allergy Asthma Proc. 2008, **29** (3): 225–31. PMID 18387221. doi:10.2500/aap.2008.29.3107.
* Ke LQ, Yang K, Li J, Li CM. Danazol for uterine fibroids. Cochrane Database Syst Rev. July 2009, (3): CD007692. PMID 19588442. doi:10.1002/14651858.CD007692.pub2.
* Letchumanan P, Thumboo J. Danazol in the treatment of systemic lupus erythematosus: a qualitative systematic review. Semin. Arthritis Rheum. February 2011, **40** (4): 298–306. PMID 20541792. doi:10.1016/j.semarthrit.2010.03.005.
17230-88-5