Title: DETRDistill: A Simple Knowledge Distillation Framework for DETR-Families. Abstract: Transformer-based detectors (DETRs) have attracted great attention due to their sparse training paradigm and the removal of post-processing operations, but the huge model can be computationally time-consuming and difficult to be deployed in real-world applications. To tackle this problem, knowledge distillation (KD) can be employed to compress the huge model by constructing a simple teacher-student learning framework. Different from the traditional CNN detectors, where the distillation targets can be naturally aligned through the feature map, DETR regards object detection as a set prediction problem, leading to an unclear relationship between teacher and student during distillation. In this paper, we propose DETRDistill, a novel knowledge distillation dedicated to DETR-families. We first explore a sparse matching paradigm with progressive stage-by-stage instance distillation. Considering the diverse attention mechanisms adopted in different DETRs, we propose attention-agnostic feature distillation module to overcome the ineffectiveness of conventional feature imitation. Finally, to fully leverage the intermediate products from the teacher, we introduce teacher-assisted assignment distillation, which greatly alleviates the instability of label assignment caused by bipartite graph matching. Extensive experiments demonstrate that our distillation method achieves significant improvement on various competitive DETR approaches, without introducing extra consumption in the inference phase. To the best of our knowledge, this is the first systematic study to explore a general distillation method for DETR-style detectors.