Title: Temporal Label Smoothing for Early Prediction of Adverse Events. Abstract: Models that can predict adverse events ahead of time with low false-alarm rates are critical to the acceptance of decision support systems in the medical community. This challenging machine learning task remains typically treated as a simple binary classification, with few bespoke methods proposed to leverage temporal dependency across samples. We propose Temporal Label Smoothing (TLS), a novel learning strategy that modulates smoothing strength as a function of proximity to the event of interest. This regularization technique reduces model confidence at the class boundary, where the signal is often noisy or uninformative, thus allowing training to focus on clinically informative data points away from this boundary region. From a theoretical perspective, we also show that our method can be framed as an extension of multi-horizon prediction, a learning heuristic proposed in other early prediction work. TLS empirically matches or outperforms all competitor methods across all evaluation measures on various early prediction benchmark tasks. In particular, our approach significantly improves performance on clinically-relevant metrics such as event recall under low false-alarm rates.