The TCM gene therapy based on human gene barrier technology, created by Dr. Sheng-Mingshan in the Teaching and Researching Base of Nanjing TCM University, is a treatment that opens human gene barrier by means of human gene barrier regulator in Chinese medicine, and uses ordinary Chinese medicine (or western medicine) as the genetic information encoding program or the genetic information encoding rectifying program to reedit and modify the gene message of human living cells, applied to treat various genetic diseases and clinical difficult syndromes, and achieved a good effect in clinical treatment.