In the Cox model for time dependent, with respect to progression-free survival (PFS), compared with the placebo group, the patients accepting all ninth injection of OBI822 / 821 also have a trend of improvement (HR, 0.66 [95% CI, 0.42- 1.01] P =.057).Generally speaking, the patients in the study period was well tolerated for this therapy, the main side effects from the vaccine include mild fever and local injection reactions.