According to this research on NMN, the substance has clinically proven various health benefits after a 12-month-long NMN administration to regular chow-fed wild-type mice during their normal aging, which includes metabolism. NMN alleviates psychological decline, suppresses age-associated body weight gain, enhances energy metabolism, improves insulin sensitivity, improves eye function and other features with no toxicity, prevents age-associated gene expression changes in a tissue-specific manner, and is an effective anti-aging intervention that could be translated to humans.