For iexplore.exe, one of the DLLs it looks for is vbscript.dll. Therefore if ASR is enabled for iexplore.exe (with the default settings), when iexplore.exe loads vbscript.dll, the ASR mitigation is triggered. To resolve this issue, make sure that the zone exclusions for Trusted Sites and Intranet Zones are configured, and that all the content that uses VBScript is associated with one of those two zones.