We are experiencing the era of great innovation in treatment for prostate cancer. This has happened to other cancers (such as colon and breast cancer) but prostate cancer field has been left behind until now. Looking at biology of other cancers, such as colon cancer and kidney cancer, for example, we know that once we have effective treatment for metastatic disease, a whole new world of treatment options emerges. For example, for advanced and metastatic colon cancer and kidney cancer, surgical removal offers improvement in survival, a major benefit.