Genotype and allele frequencies calculated using the frequency count, study comparing genotype and allele frequencies are used chi-square test, two groups were compared using t test, odds ratio (odd ratio, OR) calculated using the Logistic regression analysis. All the data were applied SPSS 13.0 For Windows statistical package for statistical analysis, P <0.05 was considered statistically significant. of the number of factors and levels shown in Table 1.