SGS has adopted a proactive strategy in applying the CDISC standards to clinical trials. We developed our first Implementation Guide for SDTM already in 2005, built up a CDASH based eLibrary and are able to deliver SDTM datasets at database lock. Since then, SGS has delivered more than 150 trials in the SDTM structure at database lock, and converted more than 230 trials to the SDTM structure for submission to the FDA.