In 2010, researchers at the Pittsburgh Medical Center in the United States recruited 10 men and women over 40 years of age, characterized by obesity (BMI>25), symptoms of metabolic syndrome such as hypertension and hyperlipidemia, and cardiovascular disease. The high-risk group of diseases, the experimental process of giving hydrogen-containing reducing water, 1.5~2 liters per day for eight weeks, the antioxidant enzyme SOD in the urine increased significantly; the oxidative lipid index (MDA) decreased significantly, and High-density cholesterol (HDL) increased slightly during the fourth week of administration; total cholesterol decreased significantly.