Do not rely exclusively on looking for malicious or malformed inputs. This is likely to miss at least one undesirable input, especially if the code's environment changes. This can give attackers enough room to bypass the intended validation. However, denylists can be useful for detecting potential attacks or determining which inputs are so malformed that they should be rejected outright.
When constructing SQL query strings, use stringent allowlists that limit the character set based on the expected value of the parameter in the request. This will indirectly limit the scope of an attack, but this technique is less important than proper output encoding and escaping.
Note that proper output encoding, escaping, and quoting is the most effective solution for preventing SQL injection, although input validation may provide some defense-in-depth. This is because it effectively limits what will appear in output. Input validation will not always prevent SQL injection, especially if you are required to support free-form text fields that could contain arbitrary characters. For example, the name "O'Reilly" would likely pass the validation step, since it is a common last name in the English language. However, it cannot be directly inserted into the database because it contains the "'" apostrophe character, which would need to be escaped or otherwise handled. In this case, stripping the apostrophe might reduce the risk of SQL injection, but it would produce incorrect behavior because the wrong name would be recorded.
When feasible, it may be safest to disallow meta-characters entirely, instead of escaping them. This will provide some defense in depth. After the data is entered into the database, later processes may neglect to escape meta-characters before use, and you may not have control over those processes.