Statin Drugs -

Like many drugs, statins don't come without risks and have some serious side effects that people considering their use should be aware of, but approaching 30 years later, they remain among the most widely prescribed drugs in the world, with estimated annual sales of $\$ 14$ billion. Atorvastatin (Lipitor), simvastatin (Zocor), rosuvastatin (Crestor), pravastatin (Pravachol), and lovastatin (Mevacor) are some examples. An X-ray crystal structure of the active site in the HMG-CoA reductase enzyme is shown in the accompanying graphic, along with a molecule of atorvastatin (purple) that is tightly bound in the active site and stops the enzyme from functioning. A good understanding of organic chemistry certainly paid off in this instance.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1081.jpg?height=681&width=706&top_left_y=1313&top_left_x=441)
<img class="imgSvg" id = "m6sn3qc9sl1h4c8njd9" src="data:image/svg+xml;base64,<svg id="smiles-m6sn3qc9sl1h4c8njd9" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 429 344.0151309368971" style="width: 428.5759620626493px; height: 344.0151309368971px; overflow: visible;"><defs><linearGradient id="line-m6sn3qc9sl1h4c8njd9-1" gradientUnits="userSpaceOnUse" x1="215.11925835065787" y1="120.57135302254605" x2="246.61925835056343" y2="120.57127588523889"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-3" gradientUnits="userSpaceOnUse" x1="246.61925835056343" y1="120.57127588523889" x2="262.3693251533838" y2="93.29151423476445"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-5" gradientUnits="userSpaceOnUse" x1="246.61925835056343" y1="120.57127588523889" x2="262.3692583505634" y2="147.8510761044487"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-7" gradientUnits="userSpaceOnUse" x1="264.9093259342459" y1="153.81927991047993" x2="289.9712776975264" y2="156.45339718482478"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-9" gradientUnits="userSpaceOnUse" x1="262.3692583505634" y1="147.8510761044487" x2="293.696698054664" y2="151.1437226973798"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-11" gradientUnits="userSpaceOnUse" x1="249.55705409367573" y1="176.62775802019064" x2="262.3692583505634" y2="147.8510761044487"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-13" gradientUnits="userSpaceOnUse" x1="293.696698054664" y1="151.1437226973798" x2="314.7743121549681" y2="127.73466069484186"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-15" gradientUnits="userSpaceOnUse" x1="293.696698054664" y1="151.1437226973798" x2="300.2459163154235" y2="181.95537212049467"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-17" gradientUnits="userSpaceOnUse" x1="249.55705409367573" y1="176.62775802019064" x2="272.9661160962137" y2="197.70537212049467"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-19" gradientUnits="userSpaceOnUse" x1="218.74540467056084" y1="183.1769762809501" x2="249.55705409367573" y2="176.62775802019064"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-21" gradientUnits="userSpaceOnUse" x1="314.18487572085104" y1="130.50770769951657" x2="344.9965091061256" y2="137.05700141192827"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-23" gradientUnits="userSpaceOnUse" x1="315.3637485890851" y1="124.96161369016716" x2="346.17538197435965" y2="131.51090740257885"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-25" gradientUnits="userSpaceOnUse" x1="305.0402034702478" y1="97.77640426837317" x2="314.7743121549681" y2="127.73466069484186"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-27" gradientUnits="userSpaceOnUse" x1="300.2459163154235" y1="181.95537212049467" x2="329.0225982311654" y2="194.76757637738237"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-29" gradientUnits="userSpaceOnUse" x1="272.85909611813463" y1="191.2200080810369" x2="294.6829362935025" y2="178.6200080810369"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-31" gradientUnits="userSpaceOnUse" x1="272.9661160962137" y1="197.70537212049467" x2="300.2459163154235" y2="181.95537212049467"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-33" gradientUnits="userSpaceOnUse" x1="269.6734695032826" y1="229.03281182459529" x2="272.9661160962137" y2="197.70537212049467"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-35" gradientUnits="userSpaceOnUse" x1="197.66779057025678" y1="159.7679142784122" x2="218.74540467056084" y2="183.1769762809501"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-37" gradientUnits="userSpaceOnUse" x1="305.0402034702478" y1="97.77640426837317" x2="326.1178175705518" y2="74.36734226583525"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-39" gradientUnits="userSpaceOnUse" x1="334.9037441439448" y1="197.503179190767" x2="355.29097240219346" y2="182.6909908329967"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-41" gradientUnits="userSpaceOnUse" x1="329.0225982311654" y1="194.76757637738237" x2="354.50663355397626" y2="176.25234093016945"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-43" gradientUnits="userSpaceOnUse" x1="329.0225982311654" y1="194.76757637738237" x2="332.3152448240965" y2="226.09501608148298"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-45" gradientUnits="userSpaceOnUse" x1="268.88913065506534" y1="235.47146172742254" x2="289.276358913314" y2="250.28365008519285"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-47" gradientUnits="userSpaceOnUse" x1="269.6734695032826" y1="229.03281182459529" x2="295.15750482609343" y2="247.54804727180817"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-49" gradientUnits="userSpaceOnUse" x1="240.89678758754064" y1="241.84501608148304" x2="269.6734695032826" y2="229.03281182459529"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-51" gradientUnits="userSpaceOnUse" x1="166.85614114714193" y1="166.31713253917164" x2="197.66779057025678" y2="159.7679142784122"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-53" gradientUnits="userSpaceOnUse" x1="322.74967622741553" y1="45.6527636707617" x2="330.5369044856642" y2="69.61938788139956"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-55" gradientUnits="userSpaceOnUse" x1="316.38378224774095" y1="44.40906200253792" x2="326.1178175705518" y2="74.36734226583525"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-57" gradientUnits="userSpaceOnUse" x1="326.1178175705518" y1="74.36734226583525" x2="356.9294669936667" y2="80.91656052659465"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-59" gradientUnits="userSpaceOnUse" x1="354.50663355397626" y1="176.25234093016945" x2="383.28331546971816" y2="189.06454518705715"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-61" gradientUnits="userSpaceOnUse" x1="337.4991097819105" y1="222.1964337623382" x2="360.52045531450403" y2="232.44619716784837"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-63" gradientUnits="userSpaceOnUse" x1="332.3152448240965" y1="226.09501608148298" x2="361.0919267398384" y2="238.90722033837068"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-65" gradientUnits="userSpaceOnUse" x1="291.86485823316235" y1="278.87548697590876" x2="295.15750482609343" y2="247.54804727180817"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-67" gradientUnits="userSpaceOnUse" x1="243.5723448006408" y1="270.63238820190116" x2="246.20646207498564" y2="245.57043643862067"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-69" gradientUnits="userSpaceOnUse" x1="237.60414099460957" y1="273.1724557855836" x2="240.89678758754064" y2="241.84501608148304"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-71" gradientUnits="userSpaceOnUse" x1="143.44707914460403" y1="187.3947466394757" x2="166.85614114714193" y2="166.31713253917164"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-73" gradientUnits="userSpaceOnUse" x1="166.85614114714193" y1="166.31713253917164" x2="173.4053594079014" y2="197.12878196228652"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-75" gradientUnits="userSpaceOnUse" x1="145.77852704683784" y1="142.90807053663377" x2="166.85614114714193" y2="166.31713253917164"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-77" gradientUnits="userSpaceOnUse" x1="316.38378224774095" y1="44.40906200253792" x2="337.46139634804496" y2="21"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-79" gradientUnits="userSpaceOnUse" x1="354.8235972432403" y1="74.78168378828613" x2="371.68568852348346" y2="56.05443418625576"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-81" gradientUnits="userSpaceOnUse" x1="356.9294669936667" y1="80.91656052659465" x2="378.0070810939707" y2="57.507498524056686"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-83" gradientUnits="userSpaceOnUse" x1="377.9736409822732" y1="192.7899655441948" x2="380.6077582566181" y2="217.8519173074753"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-85" gradientUnits="userSpaceOnUse" x1="383.28331546971816" y1="189.06454518705715" x2="386.5759620626493" y2="220.39198489115776"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-87" gradientUnits="userSpaceOnUse" x1="361.0919267398384" y1="238.90722033837068" x2="386.5759620626493" y2="220.39198489115776"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-89" gradientUnits="userSpaceOnUse" x1="263.6596477427548" y1="285.22666806227414" x2="286.6809932753484" y2="274.976904656764"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-91" gradientUnits="userSpaceOnUse" x1="263.08817631742045" y1="291.6876912327965" x2="291.86485823316235" y2="278.87548697590876"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-93" gradientUnits="userSpaceOnUse" x1="237.60414099460957" y1="273.1724557855836" x2="263.08817631742045" y2="291.6876912327965"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-95" gradientUnits="userSpaceOnUse" x1="114.96687762372298" y1="149.45728879739323" x2="145.77852704683784" y2="142.90807053663377"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-97" gradientUnits="userSpaceOnUse" x1="339.36370200341975" y1="27.20101872223661" x2="364.0130215419116" y2="32.44039333084412"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-99" gradientUnits="userSpaceOnUse" x1="337.46139634804496" y1="21" x2="368.2730457711598" y2="27.549218260759375"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-101" gradientUnits="userSpaceOnUse" x1="368.2730457711598" y1="27.549218260759375" x2="378.0070810939707" y2="57.507498524056686"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-103" gradientUnits="userSpaceOnUse" x1="259.79552972448937" y1="323.0151309368971" x2="263.08817631742045" y2="291.6876912327965"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-105" gradientUnits="userSpaceOnUse" x1="91.55781562118509" y1="170.5349028976973" x2="114.96687762372298" y2="149.45728879739323"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-107" gradientUnits="userSpaceOnUse" x1="114.96687762372298" y1="149.45728879739323" x2="121.51609588448245" y2="180.26893822050812"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-109" gradientUnits="userSpaceOnUse" x1="93.88926352341892" y1="126.04822679485535" x2="114.96687762372298" y2="149.45728879739323"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-111" gradientUnits="userSpaceOnUse" x1="63.07761410030406" y1="132.5974450556148" x2="93.88926352341892" y2="126.04822679485535"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-113" gradientUnits="userSpaceOnUse" x1="44.106815580228414" y1="107.29139778404956" x2="65.18442968053247" y2="130.70045978658743"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-115" gradientUnits="userSpaceOnUse" x1="39.893184419771586" y1="111.0853683221043" x2="60.97079852007565" y2="134.49443032464217"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qc9sl1h4c8njd9-117" gradientUnits="userSpaceOnUse" x1="53.34357877749326" y1="162.55572531891215" x2="63.07761410030406" y2="132.5974450556148"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient></defs><mask id="text-mask-m6sn3qc9sl1h4c8njd9"><rect x="0" y="0" width="100%" height="100%" fill="white"></rect><circle cx="345.5859455402426" cy="134.28395440725356" r="7.875" fill="black"></circle><circle cx="305.0402034702478" cy="97.77640426837317" r="7.875" fill="black"></circle><circle cx="259.79552972448937" cy="323.0151309368971" r="7.875" fill="black"></circle><circle cx="249.55705409367573" cy="176.62775802019064" r="7.875" fill="black"></circle><circle cx="143.44707914460403" cy="187.3947466394757" r="7.875" fill="black"></circle><circle cx="173.4053594079014" cy="197.12878196228652" r="7.875" fill="black"></circle><circle cx="91.55781562118509" cy="170.5349028976973" r="7.875" fill="black"></circle><circle cx="121.51609588448245" cy="180.26893822050812" r="7.875" fill="black"></circle><circle cx="42" cy="109.18838305307693" r="7.875" fill="black"></circle><circle cx="53.34357877749326" cy="162.55572531891215" r="7.875" fill="black"></circle></mask><style>
                .element-m6sn3qc9sl1h4c8njd9 {
                    font: 14px Helvetica, Arial, sans-serif;
                    alignment-baseline: 'middle';
                }
                .sub-m6sn3qc9sl1h4c8njd9 {
                    font: 8.4px Helvetica, Arial, sans-serif;
                }
            </style><g mask="url(#text-mask-m6sn3qc9sl1h4c8njd9)"><line x1="215.11925835065787" y1="120.57135302254605" x2="246.61925835056343" y2="120.57127588523889" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-1')"></line><line x1="246.61925835056343" y1="120.57127588523889" x2="262.3693251533838" y2="93.29151423476445" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-3')"></line><line x1="246.61925835056343" y1="120.57127588523889" x2="262.3692583505634" y2="147.8510761044487" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-5')"></line><line x1="264.9093259342459" y1="153.81927991047993" x2="289.9712776975264" y2="156.45339718482478" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-7')"></line><line x1="262.3692583505634" y1="147.8510761044487" x2="293.696698054664" y2="151.1437226973798" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-9')"></line><line x1="249.55705409367573" y1="176.62775802019064" x2="262.3692583505634" y2="147.8510761044487" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-11')"></line><line x1="293.696698054664" y1="151.1437226973798" x2="314.7743121549681" y2="127.73466069484186" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-13')"></line><line x1="293.696698054664" y1="151.1437226973798" x2="300.2459163154235" y2="181.95537212049467" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-15')"></line><line x1="249.55705409367573" y1="176.62775802019064" x2="272.9661160962137" y2="197.70537212049467" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-17')"></line><line x1="218.74540467056084" y1="183.1769762809501" x2="249.55705409367573" y2="176.62775802019064" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-19')"></line><line x1="314.18487572085104" y1="130.50770769951657" x2="344.9965091061256" y2="137.05700141192827" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-21')"></line><line x1="315.3637485890851" y1="124.96161369016716" x2="346.17538197435965" y2="131.51090740257885" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-23')"></line><line x1="305.0402034702478" y1="97.77640426837317" x2="314.7743121549681" y2="127.73466069484186" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-25')"></line><line x1="300.2459163154235" y1="181.95537212049467" x2="329.0225982311654" y2="194.76757637738237" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-27')"></line><line x1="272.85909611813463" y1="191.2200080810369" x2="294.6829362935025" y2="178.6200080810369" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-29')"></line><line x1="272.9661160962137" y1="197.70537212049467" x2="300.2459163154235" y2="181.95537212049467" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-31')"></line><line x1="269.6734695032826" y1="229.03281182459529" x2="272.9661160962137" y2="197.70537212049467" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-33')"></line><line x1="197.66779057025678" y1="159.7679142784122" x2="218.74540467056084" y2="183.1769762809501" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-35')"></line><line x1="305.0402034702478" y1="97.77640426837317" x2="326.1178175705518" y2="74.36734226583525" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-37')"></line><line x1="334.9037441439448" y1="197.503179190767" x2="355.29097240219346" y2="182.6909908329967" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-39')"></line><line x1="329.0225982311654" y1="194.76757637738237" x2="354.50663355397626" y2="176.25234093016945" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-41')"></line><line x1="329.0225982311654" y1="194.76757637738237" x2="332.3152448240965" y2="226.09501608148298" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-43')"></line><line x1="268.88913065506534" y1="235.47146172742254" x2="289.276358913314" y2="250.28365008519285" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-45')"></line><line x1="269.6734695032826" y1="229.03281182459529" x2="295.15750482609343" y2="247.54804727180817" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-47')"></line><line x1="240.89678758754064" y1="241.84501608148304" x2="269.6734695032826" y2="229.03281182459529" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-49')"></line><line x1="166.85614114714193" y1="166.31713253917164" x2="197.66779057025678" y2="159.7679142784122" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-51')"></line><line x1="322.74967622741553" y1="45.6527636707617" x2="330.5369044856642" y2="69.61938788139956" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-53')"></line><line x1="316.38378224774095" y1="44.40906200253792" x2="326.1178175705518" y2="74.36734226583525" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-55')"></line><line x1="326.1178175705518" y1="74.36734226583525" x2="356.9294669936667" y2="80.91656052659465" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-57')"></line><line x1="354.50663355397626" y1="176.25234093016945" x2="383.28331546971816" y2="189.06454518705715" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-59')"></line><line x1="337.4991097819105" y1="222.1964337623382" x2="360.52045531450403" y2="232.44619716784837" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-61')"></line><line x1="332.3152448240965" y1="226.09501608148298" x2="361.0919267398384" y2="238.90722033837068" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-63')"></line><line x1="291.86485823316235" y1="278.87548697590876" x2="295.15750482609343" y2="247.54804727180817" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-65')"></line><line x1="243.5723448006408" y1="270.63238820190116" x2="246.20646207498564" y2="245.57043643862067" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-67')"></line><line x1="237.60414099460957" y1="273.1724557855836" x2="240.89678758754064" y2="241.84501608148304" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-69')"></line><line x1="143.44707914460403" y1="187.3947466394757" x2="166.85614114714193" y2="166.31713253917164" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-71')"></line><line x1="166.85614114714193" y1="166.31713253917164" x2="166.85614114714193" y2="166.31713253917164" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="167.61844067609073" y1="170.98566008307287" x2="168.05860709642096" y2="170.89209982220487" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="168.38074020503956" y1="175.6541876269741" x2="169.2610730457" y2="175.46706710523813" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="169.14303973398836" y1="180.3227151708753" x2="170.463538994979" y2="180.04203438827136" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="169.90533926293716" y1="184.99124271477655" x2="171.66600494425802" y2="184.6170016713046" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="170.667638791886" y1="189.65977025867778" x2="172.86847089353705" y2="189.19196895433782" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="171.4299383208348" y1="194.32829780257902" x2="174.07093684281608" y2="193.76693623737106" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-73')"></line><line x1="145.77852704683784" y1="142.90807053663377" x2="166.85614114714193" y2="166.31713253917164" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-75')"></line><line x1="316.38378224774095" y1="44.40906200253792" x2="337.46139634804496" y2="21" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-77')"></line><line x1="354.8235972432403" y1="74.78168378828613" x2="371.68568852348346" y2="56.05443418625576" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-79')"></line><line x1="356.9294669936667" y1="80.91656052659465" x2="378.0070810939707" y2="57.507498524056686" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-81')"></line><line x1="377.9736409822732" y1="192.7899655441948" x2="380.6077582566181" y2="217.8519173074753" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-83')"></line><line x1="383.28331546971816" y1="189.06454518705715" x2="386.5759620626493" y2="220.39198489115776" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-85')"></line><line x1="361.0919267398384" y1="238.90722033837068" x2="386.5759620626493" y2="220.39198489115776" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-87')"></line><line x1="263.6596477427548" y1="285.22666806227414" x2="286.6809932753484" y2="274.976904656764" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-89')"></line><line x1="263.08817631742045" y1="291.6876912327965" x2="291.86485823316235" y2="278.87548697590876" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-91')"></line><line x1="237.60414099460957" y1="273.1724557855836" x2="263.08817631742045" y2="291.6876912327965" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-93')"></line><line x1="114.96687762372298" y1="149.45728879739323" x2="145.77852704683784" y2="142.90807053663377" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-95')"></line><line x1="339.36370200341975" y1="27.20101872223661" x2="364.0130215419116" y2="32.44039333084412" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-97')"></line><line x1="337.46139634804496" y1="21" x2="368.2730457711598" y2="27.549218260759375" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-99')"></line><line x1="368.2730457711598" y1="27.549218260759375" x2="378.0070810939707" y2="57.507498524056686" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-101')"></line><line x1="259.79552972448937" y1="323.0151309368971" x2="263.08817631742045" y2="291.6876912327965" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-103')"></line><line x1="91.55781562118509" y1="170.5349028976973" x2="114.96687762372298" y2="149.45728879739323" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-105')"></line><line x1="114.96687762372298" y1="149.45728879739323" x2="114.96687762372298" y2="149.45728879739323" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="115.72917715267178" y1="154.12581634129447" x2="116.169343573002" y2="154.03225608042646" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="116.49147668162061" y1="158.7943438851957" x2="117.37180952228104" y2="158.6072233634597" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="117.25377621056941" y1="163.4628714290969" x2="118.57427547156006" y2="163.18219064649296" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="118.01607573951824" y1="168.13139897299814" x2="119.77674142083909" y2="167.7571579295262" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="118.77837526846706" y1="172.79992651689938" x2="120.97920737011812" y2="172.33212521255942" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="119.54067479741587" y1="177.4684540608006" x2="122.18167331939715" y2="176.90709249559265" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-107')"></line><line x1="93.88926352341892" y1="126.04822679485535" x2="114.96687762372298" y2="149.45728879739323" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-109')"></line><line x1="63.07761410030406" y1="132.5974450556148" x2="93.88926352341892" y2="126.04822679485535" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-111')"></line><line x1="44.106815580228414" y1="107.29139778404956" x2="65.18442968053247" y2="130.70045978658743" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-113')"></line><line x1="39.893184419771586" y1="111.0853683221043" x2="60.97079852007565" y2="134.49443032464217" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-115')"></line><line x1="53.34357877749326" y1="162.55572531891215" x2="63.07761410030406" y2="132.5974450556148" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qc9sl1h4c8njd9-117')"></line></g><g><text x="215.11925835065787" y="120.57135302254605" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="246.61925835056343" y="120.57127588523889" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="262.3693251533838" y="93.29151423476445" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="262.3692583505634" y="147.8510761044487" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="293.696698054664" y="151.1437226973798" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="314.7743121549681" y="127.73466069484186" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="341.6484455402426" y="139.53395440725356" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O</tspan></text><text x="345.5859455402426" y="134.28395440725356" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="310.2902034702478" y="103.02640426837317" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: rtl; unicode-bidi: bidi-override;
            "><tspan>N</tspan><tspan style="unicode-bidi: plaintext;">H</tspan></text><text x="305.0402034702478" y="97.77640426837317" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="326.1178175705518" y="74.36734226583525" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="316.38378224774095" y="44.40906200253792" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="337.46139634804496" y="21" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="368.2730457711598" y="27.549218260759375" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="378.0070810939707" y="57.507498524056686" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="356.9294669936667" y="80.91656052659465" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="300.2459163154235" y="181.95537212049467" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="329.0225982311654" y="194.76757637738237" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="354.50663355397626" y="176.25234093016945" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="383.28331546971816" y="189.06454518705715" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="386.5759620626493" y="220.39198489115776" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="361.0919267398384" y="238.90722033837068" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="332.3152448240965" y="226.09501608148298" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="272.9661160962137" y="197.70537212049467" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="269.6734695032826" y="229.03281182459529" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="295.15750482609343" y="247.54804727180817" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="291.86485823316235" y="278.87548697590876" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="263.08817631742045" y="291.6876912327965" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="254.54552972448937" y="328.2651309368971" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>F</tspan></text><text x="259.79552972448937" y="323.0151309368971" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="237.60414099460957" y="273.1724557855836" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="240.89678758754064" y="241.84501608148304" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="254.80705409367573" y="181.87775802019064" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: rtl; unicode-bidi: bidi-override;
            "><tspan>N</tspan></text><text x="249.55705409367573" y="176.62775802019064" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="218.74540467056084" y="183.1769762809501" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="197.66779057025678" y="159.7679142784122" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="166.85614114714193" y="166.31713253917164" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            ">S</text><text x="148.69707914460403" y="192.6447466394757" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: rtl; unicode-bidi: bidi-override;
            "><tspan>H</tspan></text><text x="143.44707914460403" y="187.3947466394757" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="168.1553594079014" y="202.37878196228652" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O</tspan><tspan style="unicode-bidi: plaintext;">H</tspan></text><text x="173.4053594079014" y="197.12878196228652" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="145.77852704683784" y="142.90807053663377" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="114.96687762372298" y="149.45728879739323" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            ">S</text><text x="96.80781562118509" y="175.7849028976973" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: rtl; unicode-bidi: bidi-override;
            "><tspan>H</tspan></text><text x="91.55781562118509" y="170.5349028976973" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="116.26609588448245" y="185.51893822050812" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O</tspan><tspan style="unicode-bidi: plaintext;">H</tspan></text><text x="121.51609588448245" y="180.26893822050812" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="93.88926352341892" y="126.04822679485535" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="63.07761410030406" y="132.5974450556148" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="36.75" y="114.43838305307693" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O</tspan></text><text x="42" y="109.18838305307693" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="48.09357877749326" y="167.80572531891215" class="element-m6sn3qc9sl1h4c8njd9" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O<tspan baseline-shift="super" class="sub-m6sn3qc9sl1h4c8njd9">-</tspan></tspan></text><text x="53.34357877749326" y="162.55572531891215" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text></g></svg>"/>


Statin Drugs -

Atorvastatin (Lipitor)


Key Terms -

- anabolism
- gluconeogenesis
- $\beta$-oxidation pathway
- glycolysis
- catabolism
- metabolism
- citric acid cycle
- Schiff base
- deamination
- transamination


Key Terms -


Summary -

Metabolism is the sum of all chemical reactions in the body. Reactions that break down large molecules into
smaller fragments are called catabolism, and those that build up large molecules from small pieces are called anabolism. Although the details of specific biochemical pathways are sometimes complex, all the reactions that occur follow the normal rules of organic chemical reactivity.


Summary -

The catabolism of fats begins with digestion, in which ester bonds are hydrolyzed to give glycerol and fatty acids. The fatty acids are degraded in the four-step $\boldsymbol{\beta}$-oxidation pathway by removal of two carbons at a time, yielding acetyl CoA. Catabolism of carbohydrates begins with the hydrolysis of glycoside bonds to give glucose, which is degraded in the ten-step glycolysis pathway. Pyruvate, the initial product of glycolysis, is then converted into acetyl CoA. Acetyl CoA next enters the eight-step citric acid cycle, where it is further degraded into $\mathrm{CO}_{2}$. The cycle is a closed loop of reactions in which the product of the final step (oxaloacetate) is a reactant in the first step.


Summary -

Catabolism of proteins is more complex than that of fats or carbohydrates because each of the 20 different amino acids is degraded by its own unique pathway. In general, though, the amino nitrogen atoms are removed and the substances that remain are converted into compounds that enter the citric acid cycle. Most amino acids lose their nitrogen atom by transamination, a reaction in which the $-\mathrm{NH}_{2}$ group of the amino acid trades places with the keto group of an $\alpha$-keto acid such as $\alpha$-ketoglutarate. The products are a new $\alpha$-keto acid and glutamate.


Summary -

The energy released in catabolic pathways is used in the electron-transport chain to make molecules of adenosine triphosphate, ATP. ATP, the final result of food catabolism, couples to and drives many otherwise unfavorable reactions.


Summary -

Biomolecules are synthesized as well as degraded, but the pathways for anabolism and catabolism are not the exact reverse of one another. Fatty acids are biosynthesized from acetate by an 8 -step pathway, and carbohydrates are made from pyruvate by the 11-step gluconeogenesis pathway.


Additional Problems -


Visualizing Chemistry -

PROBLEM Identify the amino acid that is a catabolic precursor of each of the following $\alpha$-keto acids:
29-17 (a)
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1082.jpg?height=269&width=418&top_left_y=1416&top_left_x=485)
(b)
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1082.jpg?height=267&width=587&top_left_y=1422&top_left_x=983)


Visualizing Chemistry -

PROBLEM Identify the following intermediate in the citric acid cycle, and tell whether it has $R$ or $S$
29-18 stereochemistry:
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1082.jpg?height=261&width=437&top_left_y=1840&top_left_x=424)


Visualizing Chemistry -

PROBLEM The following compound is an intermediate in the biosynthesis of one of the 20 common $\alpha$-amino
29-19 acids. Which one is it likely to be, and what kind of chemical change must take place to complete the biosynthesis?
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1083.jpg?height=324&width=565&top_left_y=196&top_left_x=430)


Visualizing Chemistry -

PROBLEM The following compound is an intermediate in the pentose phosphate pathway, an alternative route 29-20 for glucose metabolism. Identify the sugar it is derived from.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1083.jpg?height=316&width=500&top_left_y=677&top_left_x=433)


Mechanism Problems -


Mechanism Problems -

Ribulose 5-phosphate
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1083.jpg?height=264&width=334&top_left_y=1212&top_left_x=706)


Mechanism Problems -

Ribose 5-phosphate


Mechanism Problems -

PROBLEM Another step in the pentose phosphate pathway for degrading sugars (see Problem 29-21) is the
29-22 conversion of ribose 5-phosphate to glyceraldehyde 3-phosphate. What kind of organic process is occurring? Propose a mechanism for the conversion.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1083.jpg?height=372&width=852&top_left_y=1695&top_left_x=409)


Mechanism Problems -

PROBLEM One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of 29-23 sedoheptulose 7-phosphate with glyceraldehyde 3-phosphate in the presence of a transaldolase to yield erythrose 4-phosphate and fructose 6-phosphate.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1084.jpg?height=489&width=1248&top_left_y=181&top_left_x=406)
(a) The first part of the reaction is the formation of a protonated Schiff base of sedoheptulose 7-phosphate with a lysine residue in the enzyme followed by a retro-aldol cleavage to give an enamine plus erythrose 4-phosphate. Show the structure of the enamine and the mechanism by which it is formed.
(b) The second part of the reaction is a nucleophilic addition of the enamine to glyceraldehyde 3 -phosphate followed by hydrolysis of the Schiff base to give fructose 6-phosphate. Show the mechanism.

PROBLEM One of the steps in the pentose phosphate pathway for glucose catabolism is the reaction of xylulose
29-24 5-phosphate with ribose 5-phosphate in the presence of a transketolase to give glyceraldehyde 3 -phosphate and sedoheptulose 7-phosphate.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1084.jpg?height=495&width=1258&top_left_y=1124&top_left_x=409)
(a) The first part of the reaction is nucleophilic addition of thiamin diphosphate (TPP) ylide to xylulose 5-phosphate, followed by a retro-aldol cleavage to give glyceraldehyde 3-phosphate and a TPP-containing enamine. Show the structure of the enamine and the mechanism by which it is formed.
(b) The second part of the reaction is addition of the enamine to ribose 5-phosphate followed by loss of TPP ylide to give sedoheptulose 7-phosphate. Show the mechanism.


Mechanism Problems -

PROBLEM The amino acid tyrosine is biologically degraded by a series of steps that include the following
29-25 transformations:
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1084.jpg?height=182&width=1275&top_left_y=2007&top_left_x=417)
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1084.jpg?height=199&width=874&top_left_y=2313&top_left_x=894)


Mechanism Problems -

The double-bond isomerization of maleoylacetoacetate to fumaroylacetoacetate is catalyzed by practically any nucleophile, : $\mathrm{Nu}^{-}$. Propose a mechanism.


Mechanism Problems -

PROBLEM Propose a mechanism for the conversion of fumaroylacetoacetate to fumarate plus acetoacetate 29-26 (see Problem 29-25).

PROBLEM Propose a mechanism for the conversion of acetoacetate to acetyl CoA (see Problem 29-25). 29-27


Mechanism Problems -

PROBLEM Design your own degradative pathway. You know the rules (organic mechanisms), and you've seen 29-28 the kinds of reactions that occur in the biological degradation of fats and carbohydrates into acetyl CoA. If you were Mother Nature, what series of steps would you use to degrade the amino acid serine into acetyl CoA?
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1085.jpg?height=210&width=606&top_left_y=741&top_left_x=418)


Mechanism Problems -

PROBLEM The amino acid serine is biosynthesized by a route that involves reaction of 29-29 3-phosphohydroxypyruvate with glutamate to give 3-phosphoserine. Propose a mechanism.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1085.jpg?height=169&width=174&top_left_y=1084&top_left_x=520)


Mechanism Problems -

3-Phosphoserine
PROBLEM The amino acid leucine is biosynthesized from $\alpha$-ketoisocaproate, which is itself prepared from
29-30 $\alpha$-ketoisovalerate by a multistep route that involves (1) reaction with acetyl CoA, (2) hydrolysis, (3) dehydration, (4) hydration, (5) oxidation, and (6) decarboxylation. Show the steps in the transformation, and propose a mechanism for each.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1085.jpg?height=242&width=869&top_left_y=1516&top_left_x=414)


Mechanism Problems -

PROBLEM The amino acid cysteine, $\mathrm{C}_{3} \mathrm{H}_{7} \mathrm{NO}_{2} \mathrm{~S}$, is biosynthesized from a substance called cystathionine by a 29-31 multistep pathway.
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1085.jpg?height=220&width=917&top_left_y=1901&top_left_x=417)
(a) The first step is a transamination. What is the product?
(b) The second step is an E1cB reaction. Show the products and the mechanism of the reaction.
(c) The final step is a double-bond reduction. What organic cofactor is required for this reaction, and what is the product represented by the question mark in the equation?


Enzymes and Coenzymes -

PROBLEM What chemical events occur during the digestion of food?
29-32


Enzymes and Coenzymes -

PROBLEM What is the difference between digestion and metabolism? 29-33


Enzymes and Coenzymes -

PROBLEM What is the difference between anabolism and catabolism? 29-34


Enzymes and Coenzymes -

PROBLEM Draw the structure of adenosine $5^{\prime}$-monophosphate (AMP), an intermediate in some biochemical 29-35 pathways.

PROBLEM Cyclic adenosine monophosphate (cyclic AMP), a modulator of hormone action, is related to AMP 29-36 (Problem 29-35) but has its phosphate group linked to two hydroxyl groups at C3' and C5' of the sugar. Draw the structure of cyclic AMP.


Enzymes and Coenzymes -

PROBLEM What general kind of reaction does ATP carry out? 29-37


Enzymes and Coenzymes -

PROBLEM What general kind of reaction does $\mathrm{NAD}^{+}$carry out? 29-38

PROBLEM What general kind of reaction does FAD carry out? 29-39


Enzymes and Coenzymes -

PROBLEM What enzyme cofactor is associated with each of the following kinds of reactions?
29-40 (a) Transamination
(b) Carboxylation of a ketone
(c) Decarboxylation of an $\alpha$-keto acid


Enzymes and Coenzymes -

PROBLEM Lactate, a product of glucose catabolism in oxygen-starved muscles, can be converted into pyruvate 29-41 by oxidation. What coenzyme do you think is needed? Write the equation in the normal biochemical format using a curved arrow.
<img class="imgSvg" id = "m6sn3qd3j9jdm4d5sm" src="data:image/svg+xml;base64,<svg id="smiles-m6sn3qd3j9jdm4d5sm" xmlns="http://www.w3.org/2000/svg" viewBox="0 0 166 120.74998163508141" style="width: 165.83939005463054px; height: 120.74998163508141px; overflow: visible;"><defs><linearGradient id="line-m6sn3qd3j9jdm4d5sm-1" gradientUnits="userSpaceOnUse" x1="96.55960043840727" y1="52.499999999992866" x2="123.83939005463054" y2="68.25001836489004"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qd3j9jdm4d5sm-3" gradientUnits="userSpaceOnUse" x1="96.55960043840727" y1="52.499999999992866" x2="96.55962164436804" y2="21"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qd3j9jdm4d5sm-5" gradientUnits="userSpaceOnUse" x1="69.27978961622325" y1="68.24998163508856" x2="96.55960043840727" y2="52.499999999992866"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qd3j9jdm4d5sm-7" gradientUnits="userSpaceOnUse" x1="43.41750165284074" y1="50.04478220473129" x2="70.69729126906401" y2="65.79480056962846"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qd3j9jdm4d5sm-9" gradientUnits="userSpaceOnUse" x1="40.58249834715926" y1="54.95514433565148" x2="67.8622879633825" y2="70.70516270054866"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient><linearGradient id="line-m6sn3qd3j9jdm4d5sm-11" gradientUnits="userSpaceOnUse" x1="69.27976841026248" y1="99.74998163508141" x2="69.27978961622325" y2="68.24998163508856"><stop stop-color="currentColor" offset="20%"></stop><stop stop-color="currentColor" offset="100%"></stop></linearGradient></defs><mask id="text-mask-m6sn3qd3j9jdm4d5sm"><rect x="0" y="0" width="100%" height="100%" fill="white"></rect><circle cx="96.55962164436804" cy="21" r="7.875" fill="black"></circle><circle cx="42" cy="52.49996327019139" r="7.875" fill="black"></circle><circle cx="69.27976841026248" cy="99.74998163508141" r="7.875" fill="black"></circle></mask><style>
                .element-m6sn3qd3j9jdm4d5sm {
                    font: 14px Helvetica, Arial, sans-serif;
                    alignment-baseline: 'middle';
                }
                .sub-m6sn3qd3j9jdm4d5sm {
                    font: 8.4px Helvetica, Arial, sans-serif;
                }
            </style><g mask="url(#text-mask-m6sn3qd3j9jdm4d5sm)"><line x1="96.55960043840727" y1="52.499999999992866" x2="123.83939005463054" y2="68.25001836489004" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qd3j9jdm4d5sm-1')"></line><line x1="96.55960043840727" y1="52.499999999992866" x2="96.55962164436804" y2="21" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qd3j9jdm4d5sm-3')"></line><line x1="69.27978961622325" y1="68.24998163508856" x2="96.55960043840727" y2="52.499999999992866" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qd3j9jdm4d5sm-5')"></line><line x1="43.41750165284074" y1="50.04478220473129" x2="70.69729126906401" y2="65.79480056962846" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qd3j9jdm4d5sm-7')"></line><line x1="40.58249834715926" y1="54.95514433565148" x2="67.8622879633825" y2="70.70516270054866" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qd3j9jdm4d5sm-9')"></line><line x1="69.27976841026248" y1="99.74998163508141" x2="69.27978961622325" y2="68.24998163508856" style="stroke-linecap:round;stroke-dasharray:none;stroke-width:1.26" stroke="url('#line-m6sn3qd3j9jdm4d5sm-11')"></line></g><g><text x="123.83939005463054" y="68.25001836489004" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="96.55960043840727" y="52.499999999992866" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="91.30962164436804" y="26.25" class="element-m6sn3qd3j9jdm4d5sm" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O</tspan><tspan style="unicode-bidi: plaintext;">H</tspan></text><text x="96.55962164436804" y="21" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="69.27978961622325" y="68.24998163508856" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="47.25" y="57.74996327019139" class="element-m6sn3qd3j9jdm4d5sm" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: rtl; unicode-bidi: bidi-override;
            "><tspan>O</tspan></text><text x="42" y="52.49996327019139" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text><text x="64.02976841026248" y="104.99998163508141" class="element-m6sn3qd3j9jdm4d5sm" fill="currentColor" style="
                text-anchor: start;
                writing-mode: horizontal-tb;
                text-orientation: mixed;
                letter-spacing: normal;
                direction: ltr;
            "><tspan>O<tspan baseline-shift="super" class="sub-m6sn3qd3j9jdm4d5sm">-</tspan></tspan></text><text x="69.27976841026248" y="99.74998163508141" class="debug" fill="#ff0000" style="
                font: 5px Droid Sans, sans-serif;
            "></text></g></svg>"/>


Enzymes and Coenzymes -

Lactate


Metabolism -

PROBLEM Write the equation for the final step in the $\beta$-oxidation pathway of any fatty acid with an even 29-42 number of carbon atoms.


Metabolism -

PROBLEM Show the products of each of the following reactions:
29-43
(a)
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1086.jpg?height=153&width=662&top_left_y=1647&top_left_x=482)
(b)
Product of $(\mathbf{a})+\mathrm{H}_{2} \mathrm{O} \xrightarrow{\begin{array}{l}\text { Enoyl-CoA } \\ \text { hydratase }\end{array}}$ ?
(c)
Product of (b)
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1086.jpg?height=156&width=326&top_left_y=1814&top_left_x=702)


Metabolism -

PROBLEM Why aren't the glycolysis and gluconeogenesis pathways the exact reverse of each other? 29-44


Metabolism -

PROBLEM How many moles of acetyl CoA are produced by catabolism of the following substances?
29-45 (a) 1.0 mol of glucose
(b) 1.0 mol of palmitic acid
(c) 1.0 mol of maltose

PROBLEM How many grams of acetyl CoA (MW $=809.6 \mathrm{amu})$ are produced by catabolism of the following 29-46 substances? Which substance is the most efficient precursor of acetyl CoA on a weight basis?
(a) 100.0 g of glucose
(b) 100.0 g of palmitic acid
(c) 100.0 g of maltose


Metabolism -

PROBLEM What is the structure of the $\alpha$-keto acid formed by transamination of each of the following amino 29-47 acids?
(a) Threonine
(b) Phenylalanine
(c) Asparagine


Metabolism -

PROBLEM The glycolysis pathway shown in Figure 29.8 has a number of intermediates that contain phosphate 29-48 groups. Why can 3-phosphoglyceryl phosphate and phosphoenolpyruvate transfer a phosphate group to ADP while glucose 6-phosphate cannot?


Metabolism -

PROBLEM Write a mechanism for the conversion of $\alpha$-ketoglutarate to succinyl CoA in step 4 of the citric acid 29-49 cycle (Figure 29.14).


Metabolism -

PROBLEM In step 2 of the citric acid cycle (Figure 29.14), cis-aconitate reacts with water to give ( $2 R, 3 S$ )-29-50 isocitrate. Does -OH add from the Re face of the double bond or from the Si face? What about -H? Does the addition of water occur with syn or anti geometry?
![](https://cdn.mathpix.com/cropped/2025_02_06_5556f7656cbdcaa0f9a7g-1087.jpg?height=251&width=792&top_left_y=617&top_left_x=417)