The simplest method, and the first to be used, is "alanine scanning", where every position in turn is mutated to the unreactive amino acid alanine.
Pidabdab sane pinih saderhana, taler sane kapertama kawigunayang, inggin punika "nitenin alanine", inggian sajeroning genah salegenti kauwah dados asam amino alanine sane nenten reaktif.