Panglimbak saking filogenetik ngawinang Cavalier-Smith prasida urati indik filum sané kasengguh archezoans (inggih punika eukariota amitokondriat primitif) sepatutnyané sampun kélangan mitokondria sekundernyané, katahan antuk nguwah dados organel baru: Hidrogenosom.
The advances of phylogenetic studies allowed Cavalier-Smith to realize that all the phyla thought to be archezoans (i.e. primitively amitochondriate eukaryotes) had in fact secondarily lost their mitochondria, typically by transforming them into new organelles: Hydrogenosomes.