Sickle-cell anemia is a human genetic disease that results from a single base difference within the coding region for the β-globin section of hemoglobin, causing a single amino acid change that changes hemoglobins physical properties。
Minakadi, anemia sel sabit inggih punika pinyungkan genetik manusa sané kamedalang saking pabinayan basa tunggal ring genah makaryang kode β-globin pahan saking hemoglobin, punika ngawinang nguwah asam amino tunggal sané nguwah sifat fisik hemoglobin.