Ares V
The Ares V was a plan to create a cargo rocket for the cancelled Constellation program.  Ares V was planned to launch the Earth Departure Stage and Altair lunar lander for a plan to return to the Moon in 2019.  The Ares V was supposed to complement the Ares I, which was being designed as a crew launch vehicle.  The Ares designs were selected for their anticipated overall safety, reliability and cost-effectiveness.