Great Plague of London
Though most of the people who died during the Great Plague lived in London, the plague also killed people in other areas of England. By the time the Great Plague ended, about 2.5% of England's population had died from the plague. To compare, about 2% of the entire United Kingdom's population (including soldiers and civilians) died in World War I, and about 1% of the entire United Kingdom's population died in World War II.