HAMLET (protein complex)
Endogenous human alpha-lactoalbumin serves as a cofactor in lactose synthesis, but has no tumoricidal properties. Alpha-lactoalbumin must be partially deployed to allow the release of the calcium ion and its replacement by an oleic acid molecule. Partially folded conformation is essential for HAMLET cytotoxicity. Oleic acid is needed to stabilize this molecule in the partially unfolded state. In recent years, HAMLET's structure, function and clinical applications are under investigation.