BioShock
When Jack awakens, Dr. Tenenbaum has already turned off the trigger phrase. When it becomes clear to Fontaine that he is losing control of Jack, Fontaine points out the fact that Tenenbaum has survived both World War II as a Holocaust victim and the battle in Rapture, hinting that she has a secret agenda of her own. With the help of the Little Sisters, Jack is able to track down Fontaine. Fontaine, having been cornered, injects himself with huge amounts of ADAM and becomes an monster. Jack battles Fontaine, eventually beating and allowing the Little Sisters to take the ADAM from Fontaine, killing him.