Dictyostelid
Dictyostelium shares many molecular features with macrophages. Macrophages are the human host of Legionella. The cytoskeletal composition of D. discoideum is similar to that of mammalian cells. So are the processes driven by these components, such as phagocytosis, membrane trafficking, endocytic transit and vesicle sorting. Like leukocytes, D. discoideum have chemotaxis. Hence, D. discoideum is a suitable model system to see the influence of host cell factors during Legionella infections.