Foreskin
American doctors may be more worried about possible kidney damage, especially scarring inside the kidneys. That can happen because of a bacterial infection that starts in the foreskin and urethra. The urethra is the tube urine (pee) comes out of. The infection often spreads to the bladder. While not as common, the infection can spread further to the kidneys. A serious kidney infection (called pyelonephritis) can cause scarring of the kidney. The boy may have very serious kidney problems and may even die because of a childhood urinary tract infection. Acute (very serious) pyelonephritis in the first years of life often leads to significant renal (kidney) damage that may progress to end-stage renal disease during adolescence. End-stage renal disease means the kidneys  no longer function well enough to meet the body's needs. If the person does not receive frequent kidney dialysis or a kidney transplant, the person will die.