WrestleMania 22
Rey Mysterio would go on and feud with John "Bradshaw" Layfield (JBL) over the World Heavyweight Championship. On the May 5 edition of SmackDown!, after Rey Mysterio expressed his feelings about being World Heavyweight Champion, John "Bradshaw" Layfield came out and declared himself the number one contender. Mysterio reacted by saying that he'd fight anyone at anytime. In turn, JBL announced that Mysterio would face off against Mark Henry later that night. Henry won the match via pinfall. The next week on SmackDown!, JBL announced that Mysterio would take on The Great Khali later that night. Khali won the match via pinfall. At Judgment Day, Mysterio defeated JBL via pinfall. After the pay-per view, the feud ended between the two.