Pineal gland
There is almost no melatonin in the blood in the daytime. At the end of the day, melatonin in the blood allows sleepiness in humans and other animals which sleep at night. There is melatonin in the blood all night, while the person or animal is sleeping. In the morning, there is less and less melatonin in the blood. When light enters the eyes, the melatonin of the blood goes away.