2021–22 UEFA Champions League qualifying phase and play-off round
Seeding of teams was based on their 2021 UEFA club coefficients. For the winners of the second qualifying round, whose identity was not known at the time of draw, the club coefficient of the highest-ranked remaining team in each tie was used. Prior to the draw, UEFA formed two groups in the Champions Path, of three seeded teams and three unseeded teams, in accordance with the principles set by the Club Competitions Committee, while in the League Path there were four seeded teams and four unseeded teams. Due to political reasons, teams from Ukraine and Russia in the League Path could not be drawn against each other, thus Shakhtar Donetsk and Spartak Moscow could not be drawn against each other. The first team drawn in each tie would be the home team of the first leg.