Naruto (manga)
The main enemy of the Naruto series.  Kaguya was a member of the main family of the Otsutsuki clan. The Otsutsuki clan were a race of alien ninja whose branch family's descendants include the Senju, the Uchiha, and the Hyuga. Kaguya decided to protect the world rather than feed off it like her kin. She became part of the world's Divine Tree as she worked on her ideal of world peace. Kaguya lost faith in humanity. She turned some humans into an army called trust White Zetsu. They were to defend her against other Otsutsuki. She fought with her half-human twin sons, Hagoromo and Hamura, upon learning they inherited her chakra. Kaguya became part of the Divine Tree and turned it into the Ten-Tails. When Hagoromo captured her, she was sealed in the moon. She turned into the Gedo Statue. Her chakra turned into the Nine Tailed Beasts. Before she was sealed, Kaguya made Black Zetsu.  Black Zetsu would help her to come back. They would use Indra and the Uchiha Clan.  Madara Uchiha would be her new vessel.  Naruto and Sasuke defeated her with their team.  They took out the spiritual beasts and Madara.  Then they sealed Kaguya again.