Fictional universe in Avatar
Thanator (Palulukan in Na'vi language) is a large hexapodal land predator.  Cameron personally designed the creature.  Its appearance is similar to a panther; Cameron describes the Thanator as "a panther from hell".  The director explained how the Thanator is the most fearsome creature on Pandora, "The Thanator could eat a T-Rex and have the Alien Queen for dessert."