The Silence of the Lambs
Jonathan Demme won an Academy Award for Best Director. Jodie Foster and Anthony Hopkins both won Academy Awards. The movie also won Oscars for Best Adapted Screenplay and Best Picture. It became the third and most recent movie (the other two being 1934's It Happened One Night and 1975's One Flew Over the Cuckoo's Nest) to win Academy Awards in all the major five categories: Best Picture, Best Director, Best Actor, Best Actress, and Best Adapted Screenplay. It is also the only horror movie to have won the Oscar for Best Picture.