Asthma
During an asthma attack the submucosal glands and goblet cells make too much mucous, and it is thicker than normal which makes it harder for the cilia to bring the mucous up. When airway remodeling happens the body may make many more submucosal glands and  goblet cells than normal, which means even more mucous is made. There may be too much mucous for the cilia to bring up and the airway may become blocked. This is one of the reasons that people with airway remodeling often have more severe asthma. In fatal cases the airway may have become totally plugged causing asphyxia.