National University of the Litoral
It was established as the Universidad Provincial de Santa Fe (Provincial University of Santa Fe) in 1889. The Argentine university reform of 1918 brought modernization and democratization to higher education in Argentina. The university was made the following year by a national law signed on October 17. They becane the first regional university in the country, with influence over the Argentine Littoral (Santa Fe and the Mesopotamic provinces of Entre Ríos and Corrientes).