Antioch
The new city was populated by a mix of local settlers, Athenians brought from the nearby city of Antigonia, Macedonians, and Jews (who were given full status from the beginning). The total free population of Antioch at its foundation has been estimated at between 17,000 and 25,000, not including slaves and native settlers. During the late Hellenistic period and Early Roman period, the population reached its peak of over 500,000 inhabitants (estimates vary from 400,000 to 600,000) and it was the third largest city in the world after Rome and Alexandria. By the 4th century, Antioch's declining population was about 200,000 according to John Chrysostom, a figure which again does not include slaves.