Chromosome inversion
When the homologous chromosomes pair in prophase I of meiosis, the genes on the chromosomes pair up. The only way this can happen after an inversion is if the homologous pairs form a loop. If a cross-over occurs within this inversion loop, it can lead to loss or gain of DNA. For this reason, people with inversions in their germ cells often have lower fertility. This is because the gametes are damaged.