Roanoke Colony
One idea is that the colonists went to live with the Native American tribes. They may have joined the Chowanoke tribe. The Choanoke were attacked by another tribe. The Jamestown Colony's records say that a tribe called "Mandoag" attacked the Choanoke. (Jamestown was a colony in Virginia started 20 years after Roanoke.) The word "Mandoag" is from the Algonquian language. It means 'enemy nation.' The "Mandoag" might have been the Tuscarora people or the Eno people. The historian Lee Miller wrote about this idea in the book Roanoke: solving the mystery of the lost colony (2000).