Hispaniola
Because La Isabela was an unhealthy site, Bartholomew Columbus, brother of Christopher, established a new city, La Nueva Isabela (The New Isabela) on the south coast of the island, on the left side of the Ozama river. Because a hurricane destroyed the city, it was built again but on the right side of the river and with the new name of Santo Domingo. It is the oldest permanent European city in the Americas.