Asshole
Asshole (or arsehole in British English) is slang for the anus and is also used as a word to hurt people's feelings. It's made up from the word arse, which has been used for a long time as another name for the anus. This was first added to the word hole in the sixteenth century in books, but may have been used in talking a long time before that. By the 1970s, Hustler magazine featured people they did not like as "Asshole of the month."