Battle of Chaldiran
The Safavids lost Eastern Anatolia to the Ottomans, which had been an important source of troops from the Ottoman army. Thousands of Qizilbash tribesmen were also killed. Although Ismail I himself was wounded and managed to escape after terrible hardships, he lost his prestige in Iran after he had been believed to be invincible. He lost confidence in himself and never led his troops into battle again. Tribal leaders were given authority, and the struggle for control over them became the central political issue of the Safavid dynasty and changed the balance of power within the coalition. A power struggle ensued, which lasted until the reign of his son and successor, Tahmasp I.