Byzantine Empire
During the Macedonian dynasty (9th–11th centuries), the empire expanded again and experienced the two-century-long Macedonian Renaissance, which came to an end with the defeat by the Seljuk Turks at the Battle of Manzikert in 1071. Civil wars and the ensuing Seljuk invasion led to the loss of most of Asia Minor. The empire recovered during the Komnenian restoration, and up until the Fourth Crusade, Constantinople was the largest and wealthiest city in Europe.