HAMLET (protein complex)
HAMLET cells have shown the physiological characteristics of macroautophagy, a process in which cellular components are sequestered into double-membrane-bound vesicles that fuse with lysosomes for degradation. HAMLET and cells under amino acid starvation conditions (an initiator of macroautophagy) showed similar expression patterns of autophagocytotic proteins and responded equally well to the addition of inhibitors of macroautophagy.