Voyager 1
Voyager 1 research team announced on August 25, 2012 that it had left the solar system. It passed out of the heliosphere and into interstellar space. It's the most distant man-made object. On February 17, 1998, Voyager 1 became the Earth's farthest spacecraft from the Earth, when it overtook Pioneer 10 at a total distance of 70 AU, which is 6.5 billion miles from the Sun. It's also the first man-made object to leave the solar system. As of September 20, 2021, it was  from Earth.