BioShock
If the player harvested (and thereby killed) all or almost all of the Little Sisters, the game ends with Jack turning on the Sisters after defeating Fontaine, presumably killing them all and taking their ADAM. Tenenbaum narrates what occurred, angry Jack and his actions, voice thick with anger. Later in the second ending, a George Washington-class submarine carrying nuclear missiles comes across the wreckage of the plane and is suddenly surrounded by bathyspheres containing Splicers. The Splicers kill all hands aboard the submarine and take control of it.