Madame Web
Madame Web (Cassandra Webb) is a fictional character appearing in American comic books published by Marvel Comics. Madame Web first appeared in The Amazing Spider-Man #210, published November 1980, and was created by the late writer Denny O'Neil and artist John Romita, Jr. She is usually depicted as a supporting character in the Spider-Man comic book series. She is depicted as an elder woman with myasthenia gravis and thus was connected to a life support system that looked like a spider web. Due to her age and medical condition Madame Web never actively fought any villains.