Domenico Ghirlandaio
Ghirlandaio died in 1494 of an contagious fever and was buried in Santa Maria Novella. The day and month of his birth and death are not known, but he died in early January of his forty-fifth year.  He had been married two times and had six children. One of his three sons, Ridolfo Ghirlandaio, also became a noted painter in Florence.