Septicemic plague
The septicemic plague was the least common of the three plagues that occurred from 1348 to 1350. Like the others, the septicemic plague spread from the East through trade routes on the Black Sea and down to the Mediterranean Sea. Major port cities such as Venice and Florence were hit the hardest. The three plagues that are part of the Black Death were a major factor in the Peasant's Revolt of 1381.