The Mask: The Animated Series
The main villain, Dr. Pretorius (voiced by Tim Curry), was a madman who had his own head removed from his body and placed on tiny, spider-like robotic legs, which could attach to a larger android body. His plans always revolved around either obtaining or controlling the Mask (Pretorius is one of the few characters in the series aware of The Mask's true identity), or as part of some increasingly insane "science experiments" which, if carried out, would result in the death of thousands or even the end of mankind. He mostly pronounces Ipkiss' last name as "Ipp-kiss". Pretorius was also likely a parody of drug dealer/mob boss Eugene Rapaz from the original comics (both share the same face. Rapaz wore small, rounded-lens dark glasses and Pretorius had round optic implants that looked similar, as well).