Hillary Clinton
Clinton was the first former first lady to be elected to the United States Senate after her husband's term as president and the first former first lady to be appointed as the U.S. secretary of State. She ran for re-election to the Senate in 2006, which she won, and was considered by many in the media and politics as having a good chance to win in the race for the Democrtaic presidential nomination in 2008, but she lost to Barack Obama.