JoJo's Bizarre Adventure
In 1989, Dio Brando (now called "DIO") awakens after his tomb is recovered from the ocean floor. Because DIO had managed to capture Jonathan's body, this caused Jonathan's descendants to obtain stands. This includes Joseph, his daughter Holly Kujo, and grandson Jotaro Kujo. Holly, however, cannot handle her own Stand, causing her to only have 50 days left to live. Jotaro, Joseph, and their allies set out to defeat DIO to save Holly's life, and encounter DIO's henchmen along the way.