Randomized controlled trial
Controlled studies and trials have been done for a long time. In 1753, James Lind published a study that shows that scurvy could be treated by a diet including many lemons and oranges. Ignaz Semmelweis, a Hungarian doctor in Vienna, established the term "systematic controlled observation". Semmelweis is known today because he linked an increase in childbed fever to missing hygiene in hospitals. At the end of the 19th century, the first problem of not assigning people to test groups randomly became apparent. Austin Bradford Hill established the term "randomized controlled trial" in the 1940s. He did a study regarduing the treatment of tuberculosis with Streptomycin (an antibiotic) in the 1940s. This study is seen as thew first randomized controlled triall.