Exposure (toxicology)
A toxin's solubility is its ability to mix into a liquid.  If a toxin is not water-soluble (it cannot dissolve in water), it cannot absorb into the bloodstream.  (Plasma, the liquid part of blood, is made mostly of water.)  If a person ingests a toxin that cannot dissolve into the watery plasma, the toxin will not absorb into the bloodstream through the lining of the gastrointestinal tract.  It will pass out of the body through the gastrointestinal tract.pp. 102–103