Great Plague of London
The plague was worst in London, but it also affected other parts of England. Perhaps the most famous example was the village of Eyam in Derbyshire. Nobody knows for sure how the plague got to Eyam. However, stories say that a merchant carrying cloth from London accidentally brought the plague with him. The villagers quarantined themselves (kept themselves apart from other people and other villages) to make sure the disease would not spread any further. That kept the plague from spreading outside Eyam, but about 80% of the people in the village had died from the plague within a little over a year.