Brett Favre
He retired again after the season, but came out of retirement another time to play for the Minnesota Vikings for the 2009 season. Favre actually had the best statistical season of his career in 2009, throwing for 34 touchdowns next to seven interceptions for Minnesota. However, his season ended with an interception by Tracy Porter in a loss to the New Orleans Saints in the NFC Championship. After this, he decided to play for the Vikings in 2010 as well, but threw only 11 touchdowns next to 19 interceptions as he and the franchise struggled. Favre was often injured, and retired for good after the season ended.