Soyuz MS-19
Without an American astronaut, this launch was the first time in more than 21 years (since Soyuz TM-30 in 2000) that a Soyuz crew only included Russian cosmonauts and travelers. It was the first time in years that the ship had to be upgraded to be piloted by a single person at launch. This is also the first mission to the ISS with an entirely Russian crew.