Homestar Runner
Telltale Games, the makers of video games based on the Sam & Max comic book, made a game called Strong Bad's Cool Game for Attractive People for Windows and the Wii's WiiWare. It's an episodic game with five episodes, and it is made with 3 dimensions instead of 2 dimensions like Homestar Runner is. The first episode was called Homestar Ruiner, and ended with 8-Bit is Enough.