in the case of acute hyperactive intoxication delirium occurring in a man with a severe co-
caine use disorder, the diagnosis is 292.81 cocaine intoxication delirium, acute, hyperac-
tive. An additional diagnosis of 304.20 severe cocaine use disorder is also given. If the
intoxication delirium occurs without a comorbid substance use disorder (e.g., after a one-
time heavy use of the substance), no accompan ying substance use disorder is noted (e.g.,
292.81 phencyclidine intoxication delirium, acute, hypoactive).
ICD-10-CM. The name of the substance/ medication intoxication de lirium begins with the
specific substance (e.g., cocaine,  dexamethasone) that is presumed to be causing the delirium.
The diagnostic code is selected from the table in cluded in the criteria set, which is based on the
drug class and presence or absence of a comorbid substance use disorder. For substances that
do not fit into any of the classes (e.g., dexamethasone), the code for “other substance” should
be used; and in cases in which a substance is judg ed to be an etiological factor but the specific
class of substance is unknown, the category “unknown substance” should be used.
When recording the name of the disorder, the comorbid substance use disorder (if any) is
listed first, followed by the word “with,” foll owed by the name of th e substance intoxication
delirium, followed by the course (i.e., acute, persistent), follo wed by the specifier indicating
level of psychomotor activity (i.e., hyperactive, hypoactive, mixed level of activity). For exam-