sure in all, or almost all, activities.
B. There is evidence from the history, physical examination, or laboratory findings of both
(1) and (2):
1. The symptoms in Criterion A developed during or soon after substance intoxication
or withdrawal or after exposure to a medication.
2. The involved substance/medication is capable of producing the symptoms in Crite-
rion A.
C. The disturbance is not better explained by a depressive disorder that is not substance/
medication-induced. Such evidence of an independent depressive disorder could in-
clude the following:
The symptoms preceded the onset of the substance/medication use; the symptoms
persist for a substantial period of time (e.g., about 1 month) after the cessation of acute
withdrawal or severe intoxication; or there is other evidence suggesting the existence
of an independent non-substance/medication-i nduced depressive disorder (e.g., a his-
tory of recurrent non-substance/medication-related episodes).
D. The disturbance does not occur exclusively during the course of a delirium. 
E. The disturbance causes clinically significant distress or impairment in social, occupa-
tional, or other important areas of functioning.
Note:  This diagnosis should be made instead of a diagnosis of substance intoxication or
substance withdrawal only when the symptoms in Criterion A predominate in the clinical
picture and when they are sufficiently severe to warrant clinical attention.
Coding note:  The ICD-9-CM and ICD-10-CM codes for the [specific substance/medica-
tion]-induced depressive disorders are indicate d in the table below. Note that the ICD-10-