significant risk factor for substance-related disorders, especially opioid use disorder.
Opioid Intoxication
Diagnostic Criteria
A. Recent use of an opioid.
B. Clinically significant problematic behavioral or psychological changes (e.g., initial eu-
phoria followed by apathy, dysphoria, psychomotor agitation or retardation, impaired
judgment) that developed during, or shortly after, opioid use.
C. Pupillary constriction (or pupillary dilation due to anoxia from severe overdose) and
one (or more) of the following signs or symptoms developing during, or shortly after,
opioid use:
1. Drowsiness or coma.
2. Slurred speech.
3. Impairment in attention or memory.
D. The signs or symptoms are not attributable to another medical condition and are not
better explained by another mental disorder, including intoxication with another sub-
stance.
Specify if:
With perceptual disturbances: This specifier may be noted in the rare instance in
which hallucinations with intact reality testing or auditory, visual, or tactile illusions oc-
cur in the absence of a delirium.
Coding note:  The ICD-9-CM code is 292.89.  The ICD-10-CM code depends on whether
or not there is a comorbid opioid use disorder and whether or not there are perceptual dis-
turbances. 
For opioid intoxication without  perceptual disturbances: If a mild opioid use dis-
order is comorbid, the ICD-10-CM code is F11.129,  and if a moderate or severe opioid