the same class of substance. If a mild substance use disorder is comorbid with the
substance intoxication delirium, the 4th position character is “1,” and the clinician
should record “mild [substance] use disorder” before the substance intoxication de-
lirium (e.g., “mild cocaine use disorder with cocaine intoxication delirium”). If a mod-
erate or severe substance use disorder is comorbid with the substance intoxication
delirium, the 4th position character is “2,” and the clinician should record “moderate
[substance] use disorder” or “severe [substance] use disorder,” depending on the
severity of the comorbid substance use disorder. If there is no comorbid substance
use disorder (e.g., after a one-time heavy use of the substance), then the 4th posi-
tion character is “9,” and the clinician should record only the substance intoxication
delirium.
ICD-10-CM
ICD-9-CMWith use 
disorder, 
mildWith use 
disorder, 
moderate or 
severeWithout use 
disorder
Alcohol 291.0 F10.121 F10.221 F10.921
Cannabis 292.81 F12.121 F12.221 F12.921
Phencyclidine 292.81 F16.121 F16.221 F16.921
Other hallucinogen 292.81 F16.121 F16.221 F16.921
Inhalant 292.81 F18.121 F18.221 F18.921
Opioid 292.81 F11.121 F11.221 F11.921