D. The disturbance does not occur exclusively during the course of a delirium.
E. The disturbance causes clinically significant distress or impairment in social, occupa-
tional, or other important areas of functioning. 
Note:  This diagnosis should be made instead of a diagnosis of substance intoxication or
substance withdrawal only when the symptoms in Criterion A predominate in the clinical
picture and they are sufficiently severe to warrant clinical attention. 
Coding note:  The ICD-9-CM and ICD-10-CM codes for the [specific substance/medica-
tion]-induced anxiety disorders are indicated in the table below. Note that the ICD-10-CM
code depends on whether or not there is a comorbid substance use disorder present for
the same class of substance. If a mild substance use disorder is comorbid with the sub-
stance-induced anxiety disorder, the 4th positio n character is “1,” and the clinician should
record “mild [substance] use disorder” bef ore the substance-induced anxiety disorder
(e.g., “mild cocaine use disorder with cocai ne-induced anxiety disorder”). If a moderate or
severe substance use disorder is comorbid with the substance-induced anxiety disorder,
the 4th position character is “2,” and the clinician should record “moderate [substance] use
disorder” or “severe [substance] use disorder,” depending on the severity of the comorbid
substance use disorder. If there is no comorbid substance use disorder (e.g., after a one-