Approximately 33% of adolescents with canna bis use disorder have internalizing disor-
ders (e.g., anxiety, depressio n, posttraumatic stre ss disorder), and 60% have externalizing
disorders (e.g., conduct disorder, atte ntion-deficit/hyperactivity disorder).
Although cannabis use can impact multiple asp ects of normal human functioning, in-
cluding the cardiovascular, immune, neuromuscular, ocular, reproductive, and respira-
tory systems, as well as appetite and cognit ion/perception, there are few clear medical