use disorder, those with substance/medicati on-induced depressive disorder have higher
rates of comorbidity with any DSM-IV mental disorder; are more likely to have specific
DSM-IV disorders of pathological gambling and paranoid, histrionic, and antisocial per-
sonality disorders; and are less likely to have  persistent depressive  disorder (dysthymia).
Compared with individuals with major depressive disorder and a comorbid substance use
disorder, individuals with substance/medication-induced depressive disorder are more
likely to have alcohol use disorder, any othe r substance use disorder, and histrionic per-
sonality disorder; however, they are less likely to have persistent depressive disorder.
Depressive Disorder
 Due to Another Medical Condition
Diagnostic Criteria
A. A prominent and persistent period of depressed mood or markedly diminished interest
or pleasure in all, or almost all, activiti es that predominates in the clinical picture.
B. There is evidence from the history, physical examination, or laboratory findings that the
disturbance is the direct pathophysiological consequence of another medical condi-
tion.
C. The disturbance is not better explained by another mental disorder (e.g., adjustment
disorder, with depressed mood, in which the stressor is a serious medical condition).
D. The disturbance does not occur exclusively during the course of a delirium.
E. The disturbance causes clinically significant distress or impairment in social, occupa-
tional, or other important areas of functioning.
Coding note: The ICD-9-CM code for depressive di sorder due to another medical condi-
tion is 293.83,  which is assigned regardless of the specifier. The ICD-10-CM code de-
pends on the specifier (see below).