Level 2 measures
Domain Domain nameThreshold to guide 
further inquiryDSM-5 Level 2 Cross-Cutting Symptom 
Measurea
I. Depression Mild or greater Lev el 2—Depression—Adult (PROMIS 
Emotional Distress—Short Form)
II. Anger Mild or greater Level  2—Anger—Adult (PROMIS Emo-
tional Distress—Anger—Short Form)
III. Mania Mild or greater Level 2— Mania—Adult (Altman Self-Rating 
Mania Scale [ASRM])
IV. Anxiety Mild or greater Level 2—Anxiety—Adult (PROMIS 
Emotional Distress—Anxiety—Short 
Form)
V. Somatic symptoms Mild or greater Le vel 2—Somatic Symptom—Adult (Patient 
Health Questionnaire–15 
[PHQ-15] Somatic Symptom Severity 
Scale)
VI. Suicidal ideation Slight or greater None
VII. Psychosis Slight or greater None
VIII. Sleep problems Mild or greater Level 2—Sleep Disturbance—Adult 
(PROMIS Sleep Disturbance—Short Form)
IX. Memory Mild or greater None
X. Repetitive thoughts 
and behaviorsMild or greater Level 2—Repetitive Thoughts and 
Behaviors—Adult (Florida Obsessive-
Compulsive Inventory [FOCI] Severity 
Scale)
XI. Dissociation Mild or greater None
XII. Personality 
functioningMild or greater None
XIII. Substance use Slight or greater L evel 2—Substance Us e—Adult (adapted 
from the NIDA-Modified ASSIST)
Note. NIDA=National Institute on Drug Abuse.