pressive disorder, followed by the specification of onset (i.e., onset during intoxication, onset
during withdrawal). For example,  in the case of depressive sy mptoms occurring during with-
drawal in a man with a severe cocaine use disorder, the diagnosis is F14.24 severe cocaine use
disorder with cocaine-induced depressive disorder, with onset during withdrawal. A separate
diagnosis of the comorbid severe cocaine use disorder is not given. If the substance-induced
depressive disorder occurs without a comorbid  substance use disorder  (e.g., after a one-time
heavy use of the substance), no accompanying substance use disorder is noted (e.g., F16.94
phencyclidine-induced depr essive disorder, with onset during intoxication). When more than
one substance is judged to play a significant role in the development of depressive mood
symptoms, each should be listed separately (e .g., F15.24 severe methylphenidate use disorder
with methylphenidate-induced depressive diso rder, with onset during withdrawal; F19.94
dexamethasone-induced depressive disord er, with onset during intoxication).
Diagnostic Features
The diagnostic features of substance/medication-induced depressive disorder include the
symptoms of a depressive disorder, such as major depressive disorder; however, the de-
pressive symptoms are associated with the ingestion, injection, or inhalation of a sub-
stance (e.g., drug of abuse,  toxin, psychotropic medicati on, other medication), and the
depressive symptoms persist be yond the expected length of physiological effects, intoxi-
cation, or withdrawal period. As evidenced by  clinical history, phy sical examination, or
laboratory findings, th e relevant depressive disorder should have developed during or
within 1 month after use of a substance that is capable of producing the depressive disor-