Most varieties of E. coli are completely harmless and some others cause relatively brief bouts of mild diarrhea. However, a few aggressively pathogenic strains, such as E. coli O157:H7, can cause severe gastrointestinal upset and bloody diarrhea. The most pathogenic strains of E. coli, including O157:H7, produces a powerful toxin that damages the lining of the intestines, leading to the appearance of bright red blood mixed in with the watery stool. The toxin is called Shiga toxin and bacteria that produce it are referred to as Shiga toxin-producing E. coli, or STEC for short. Another common STEC strain that's more prevalent in Europe is labelled 0104:H4.  Bloody diarrhea from an E. coli O157:H7 infection typically begins 3-4 days after exposure, although it may occur as soon as 24 hours or as late as 1 week. Diagnosing a serious E. coli infection is fairly straightforward and involves sending a stool sample to a laboratory for testing and culture. They will look for evidence of toxins and STEC strains. Unlike many other pathogenic bacteria, STEC strains can cause severe infections even if you ingest only relatively small numbers of them. As the Shiga toxin irritates and ultimately causes erosion and ulceration of the lining of the large intestine, abdominal pain is often felt. The pain is usually described as severe cramping mixed with some burning pain. The discomfort can cause people to double-over and prevent them from leaving the house or even walking around within their homes. However, unlike more common causes of abdominal cramps, there is usually no associated severe bloating or distension of the abdomen with STEC infections.  The sudden onset of severe abdominal cramps and pain is typically followed within 24 hours by bloody diarrhea. E. coli infection can occur in people of all ages, but it's most common in children, the elderly and those who have weakened immunity. About 265,000 STEC infections occur yearly in the U.S., with the O157:H7 strain accounting for approximately 36% of cases. In addition to severe abdominal cramping and bloody diarrhea, some people with E. coli infections also experience nausea and vomiting. Although the cause is not always clear, it appears that the Shiga toxin is not directly responsible for nausea and vomiting, but rather the intense pain caused by the invasive bacteria that burrow into the lining of the intestines. The pain triggers the release of adrenaline and other hormones, which leads to nausea and vomiting. As such, keep very well hydrated while combating an E. coli infection, but avoid fatty or greasy foods that may trigger nausea.  Other minor symptoms sometimes associated with E. coli infections include mild fever (less than 101˚F) and fatigue.  The most common source of an E. coli infection is contaminated food, such as contaminated ground beef, unpasteurized milk and unwashed vegetables. Unlike other E. coli pathogens that remain on the membranes of intestines, STEC strains are invasive. After proliferating rapidly, they tightly bind to the intestinal lining and breach it, which allows for absorption of the toxins through the bowel wall. Once in circulation, the Shiga toxin attaches to white blood cells and is carried to the kidneys where it can cause acute inflammation and organ failure — referred to as hemolytic uremic syndrome or HUS. Symptoms suggestive of HUS include bloody urine and decreased urination, very pale skin tone, unexplained bruising, confusion and irritability, and swelling or puffiness throughout the body. Most people with HUS need to be hospitalized until their kidneys recover.  While most people recover from HUS, a small amount of people may have permanent kidney damage or die from it. STEC infection is recognized as the most common cause of acute kidney failure in infants and young children. In addition, your doctor may order a CBC and tests of your kidneys if you have any signs of HUS.
ابحث عن الإسهال الدموي. راقب آلام المعدة والأمعاء. تذكَّر أن بعض حالات العدوى تسبب القيء. كن حذرًا من المضاعفات الكلوية الخطيرة.