The detergent method will work best if it hasn't set in completely yet. It's also the easiest to pull off on the fly, as most people should have detergent on hand, whether you're at home or at work. If you don't have any detergent available, you can try using bar or liquid soap. It may not be as effective, but you definitely want to attempt to clean the fabric before the paint dries. Running your stained article of clothing through a wash cycle can often get rid of the stain completely. You've loosened the paint using the detergent, so your washing machine will work much more efficiently. Without pre-treating the garment, however, the washing machine might not be able to fully eliminate your stain. Certain washable or water-based paints may not require this step.  Don't wash your paint stained garment with another article of clothing, as the paint will bleed onto your other clothes. You don't want to damage your entire wardrobe just to save a single item. If the stain is still present after a wash cycle, place a bit of acetone on the front of the garment and blot with a clean sponge. Do not put acetone on fabrics that also contain acetate or triacetate, as it will melt these fabrics on contact.
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