Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit (By similarity). Plays an essential role in cell growth and survival through its regulation of ribosome biogenesis and mitotic progression (PubMed:26940494). Interacts with PES (PubMed:23909681, PubMed:25443833). Interacts with WDR12 (PubMed:23909681). Embryonic lethality when homozygous. Belongs to the WD repeat BOP1/ERB1 family.