B-H1 and B-H2 are regulated by members of the wg signaling pathway; wg and dpp. B-H1 and B-H2 are coexpressed and functionally required in R1 and R6 receptor cells and primary pigment cells for normal eye development. Coexpression is also required for the fate determination of external sensory organs, formation of notal microchaetae, formation of presutural macrochaetae, antennal development and for distal leg morphogenesis; segmentation and specification of tarsal segments 3-5. B-H1 and B-H2 are abundant in the eye-antenna imaginal disk. Expressed in R1 and R6 cells throughout larval stage until 30 hours after puparium formation, at which time expression is seen in the anterior and posterior primary pigment cells. Coexpressed in embryonic glial cells, neurons of the CNS and PNS, most latitudinal anterior cells of the developing notum and the central circular region of the leg and antennal imaginal disk throughout larval development. Coexpressed at high levels with B-H1 in embryo and pupae and at low levels in larvae. Belongs to the Antp homeobox family.