Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events (By similarity). adenosine + H(+) + H2O = inosine + NH4(+) Binds 1 zinc ion per subunit. Inhibited by adenosine deaminase inhibitor 2-DCF, but not by adenosine deaminase 1 inhibitor EHNA. Optimum pH is 6.5. Homodimer. N-glycosylated. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.