May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses(PubMed:27252646). Interacts (via C-terminus) with SHANK3 (via PDZ domain) (PubMed:16522626). Interacts (via coiled coil) with SIPA1L1 (PubMed:16522626). Can form homooligomers (PubMed:16522626). Rather found at excitatory than inhibitory synapses (PubMed:27252646). Detected in brain, with highest expression in brain cortex, caudate putamen, cerebellum and hippocampus. Detected in neuropil (at protein level). Detected in brain and kidney. Detected at low levels in newborn brain. Levels increase steadily during postnatal development up to adulthood. Belongs to the LZTS3 family.