In cancer context, protects cells from induced-DNA damage and apoptosis. Acts, at least in part, through PI3K/AKT/NFKB signaling pathway and by preventing POLB degradation. Decreases POLB ubiquitation and stabilizes its protein levels. Interacts with POLB. Interacts with AKT1 and MT1X. May interact with FAM168B. Belongs to the FAM168 family.