ABC efflux transporter that confers resistance to fluconazole (FLC) but shows no resistance to other azoles (PubMed:32209680). Is also able to transport rhodamine 6G (R-6G), a known substrate for many ABC transporters (PubMed:32209680). ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate The efflux inhibitor FK506 does not impair the transport activity. Expression is highly induced in a single triazole-resistant isolate (DI16-8). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.