Interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Interacts with MPD1. In contrast with other calnexin, yeast CNE1 does not seem to bind calcium. Present with 4760 molecules/cell in log phase SD medium. Belongs to the calreticulin family.