Nitric oxide dioxygenase involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the fungus from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress. Plays a role in virulence since nitric oxide is generated by macrophages of the host immune system. NADPH + 2 nitric oxide + 2 O2 = H(+) + NADP(+) + 2 nitrate NADH + 2 nitric oxide + 2 O2 = H(+) + NAD(+) + 2 nitrate Binds 1 FAD per subunit. Binds 1 heme b group per subunit. Inhibited by imidazoles. Expression is under the control of the CDA4 transcription factor. Induced by nitric oxide, high-iron conditions, during transition to filamentous growth, by contact with host macrophages, and during oral infection. Expression is repressed by HAP43 and CWT1. Consists of two distinct domains; a N-terminal heme-containing oxygen-binding domain and a C-terminal reductase domain with binding sites for FAD and NAD(P)H. Leads to increased susceptibility to neutrophils. Belongs to the globin family.