ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out) ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) Expressed in lung, ileum, colon and liver. Higher in liver of Eisai hyperbilirubinemic rats. Strongly up-regulated under conditions of cholestasis. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.