Acetyltransferase required for the establishment of sister chromatid cohesion (PubMed:15821733, PubMed:15958495). Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3 (PubMed:21111234). acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. Widely expressed in fetal tissues. In adult, it is expressed in thymus, placenta and small intestine. Cell-cycle regulated. Down-regulated when cells enter M phase. Expression increases again when cells enter S phase of the next cell cycle. The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the acetyltransferase family. ECO subfamily.