N-glycosylase that inhibits protein synthesis by depurinating ribosomal rRNA, and thus acts as a ribosomal inactivating protein (RIP) (PubMed:34769028, PubMed:11556814). Has adenine polynucleotide glycosidase activity on the poly(A) substrate A30-ssDNA (PubMed:11556814). Inhibits cell-free translation in rabbit reticulocyte lysate system with an IC(50) of 1 nM (PubMed:11556814, PubMed:34769028). May function in the defense response to pathogens (PubMed:11556814). Displays antifungal activity against C.comatus and P.piricola, but not against R.solani, M.arachidicola and C.gossypii (PubMed:11556814). Inhibits mycelial growth in P.piricola with an IC(50) of 2.5 uM (PubMed:11556814). Has cytotoxic activity against the human cancer cell lines Hela, HepG2, and JAR, with IC(50) of 358.8, 489.8, and 926.9 nM respectively (PubMed:34769028). It also inhibits HIV-1 reverse transcriptase activity (IC(50)=7.9 nM) and disrupts mouse embryonic development (PubMed:11556814, PubMed:19568748). Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.