Could be involved in the export of mRNA from the nucleus to the cytoplasm. Could also have a role in polarized cytoplasmic transport and localization of mRNA in neurons. Interacts with NXT1 and NXT2. Mainly localized in the cytoplasm of cells and more particularly in the cell body and neurites of hippocampal neurons. Although nuclear localization is also observed. Not detected at nuclear rim. Additional isoforms seem to exist. The NTF2 domain heterodimerizes with NXT1 and NXT2. The RNA-binding domain is a non-canonical RNP-type domain. A chromosomal aberration involving NXF5 has been observed in one patient with a syndromic form of intellectual disability and short stature. Pericentric inversion inv(X)(p21.1;q22) that interrupts NXF5. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the NXF family.