Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity (By similarity). Involved in the regulation of early eye development. Monomer. Prominent expression in the embryonal optic stalk and the distal tip of the forming vesicle. In tadpole-stage embryos predominantly found in the ciliary margin of the optic cup. Belongs to the nuclear hormone receptor family. NR2 subfamily.