The homodimer inhibits HMG-CoA reductase (HMGCR) (32% of inhibition produced by 0.6 uM), a glycoprotein involved in the control of cholesterol biosynthesis. The inhibitory effects of bumarsin are seen at much lower concentrations (0.6 uM) than that for statins such as atorvastatin (5 mM) and simvastatin (10 uM). In addition to inhibition of HMG-CoA reductase, this protein lowers cholesterol levels by inducing steroid hormone synthesis via StAR, and by increasing reverse cholesterol transport mediated by the induction of ABCA1 and APOA1. The heterodimer non-edited LVP1 induces lipolysis in rat adipocytes. Induction of lipolysis by LVP1 appears to be mediated through the beta-2 adrenergic receptor pathway (ADRB2) (By similarity). The monomer edited version, named BmKITx, similar to alpha-toxins, may modulate voltage-gated sodium channels (Nav) and may block voltage-gated potassium channels (Kv). Homodimer; disulfide-linked or monomer (edited version) or heterodimer of an alpha chain (AC Q6WJF5) and this beta chain (non-edited version). Expressed by the venom gland. Partially edited. RNA editing at this position consists of an insertion of three nucleotides, restoring the first Cys residue that forms a disulfide bond with Cys-89, giving a monomeric toxin with 4 disulfide bonds. Belongs to the long (3 C-C) scorpion toxin superfamily.