Secreted protein that plays a role in the inhibition of host innate immune system. Modulates the interaction between host SELPLG and P-selectin thereby preventing initial rolling of neutrophils toward the site of infection. Interferes with leukocyte trafficking by inhibiting host metalloproteinase-9/MMP9 activity. Associates also with two different platelet surface receptors GP1A and GP6 leading to platelet activation and aggregation. Interacts with host SELPLG; this interaction prevents SELPLG-mediated neutrophil rolling. Interacts with host MMP9 (via sialic acid-containing O-glycans); this interaction inhibits MMP9 activity. Interacts with host GP1BA and GP6; these interactions play an important role in platelet binding and activation. Induced by Sae and repressed by Agr. Belongs to the staphylococcal/streptococcal toxin family.