Lectin specific for high mannose N-glycans, recognizes the branched moiety of these glycans. Does not recognize other types of N-glycans or monosaccharides. Agglutinates trypsin-treated rabbit erythrocytes. Does not require divalent cations for activity. Inhibits HIV replication in MT4 cells with an EC(50) of 45 nM. Binds to the HIV envelope glycoprotein gp120. Stable over a wide pH range, activity is unaffected after incubation at pH 4.0-11.0. Thermostable. Activity is unaffected by heating at 80 degrees Celsius for 30 minutes, half of the original activity is retained after heating at 100 degrees Celsius for 30 minutes. Monomer. Belongs to the bacterial lectin family.