Suppress host inflammatory response. Exerts significant anti-inflammatory functions, either by directly inhibiting host secretion of inflammatory factors such as tumor necrosis factor-alpha (TNF), monocyte chemotactic protein-1 (CCL2), and interferon-gamma (IFNG) or by indirectly increasing the secretion of immunosuppressant cytokine of interleukin-10 (IL10). Also potently scavenges free radical in vitro in a rapid manner. All tested concentrations of this peptide have little effect on the cell viability. In vivo, inhibits hind paw adjuvant-induced inflammation in mouse in a dose-dependent manner. Suppress host inflammatory response. Exerts significant anti-inflammatory functions, either by directly inhibiting host secretion of inflammatory factors such as tumor necrosis factor-alpha (TNF), monocyte chemotactic protein-1 (CCL2), and interferon-gamma (IFNG) or by indirectly increasing the secretion of immunosuppressant cytokine of interleukin-10 (IL10). Also potently scavenges free radical in vitro in a rapid manner. Low concentrations of this peptide have little effect on the cell viability, whereas high concentrations increase the cell viability by 10-20%. In vivo, inhibits hind paw adjuvant-induced inflammation in mouse in a dose-dependent manner. Not studied but probably similar to Hyalomin-B1. Not studied but probably similar to Hyalomin-B1. Salivary glands. The sequence TLRTTTGYWTTVEKGNGTTPAANSTEKGNRPYGR described in the text of Wu et al., 2010 as Hyalomin-B1 is indicated as Hyalomin-B2 in Fig.1b. Therefore, it is uncertain whether the function described for Hyalomin-B1 is not the function of Hyalomin-B2.