Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity). Homooligomer and heterooligomer with other family members (By similarity). Binds LEF1, TCF7, TCF7L1, TCF7L2, UTY, HES1 and HES5 (By similarity). Expressed in bone marrow-derived macrophages. Repressed during TNFSF11/RANKL-induced osteoclast differentiation. WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain. Ubiquitinated by XIAP/BIRC4. Belongs to the WD repeat Groucho/TLE family.