Mitogen-activated protein kinase; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator (PubMed:19715768). The CWI signaling pathway regulates cell wall integrity and pyomelanin formation (PubMed:19715768). CWI controls also oxidative stress response, gliotoxin production, iron adaptation and asexual development (PubMed:21883519, PubMed:32005734). Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection (PubMed:33010083). MpkA positively modulates the expression of fumiquinazoline cluster during conidiogenesis and directly phosphorylates fmqC, and perhaps also fmqA (PubMed:33705521). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by threonine and tyrosine phosphorylation by the upstreamm MAPKK mkk2. Interacts with flbB, flbC, brlA, and rasB (PubMed:32005734). Interacts with fmqA and fmqC (PubMed:33705521). Interacts with hsp90 (PubMed:33010083). Expression is induced by cell wall-disturbing compounds. Phosphorylated by the upstreamm MAPKK mkk2 (PubMed:19715768). Phosphorylation is induced during asexual development (PubMed:25911225, PubMed:32005734). Phosphorylation is regulated by rlmA (PubMed:27473315). Results in severe sensitivity against cell wall-disturbing compounds congo red or calcofluor white, and drastic alterations of the fungal morphology (PubMed:19715768). Leads to reduced conidiation during asexual differentiation (PubMed:32005734). Abolishes the production of fumiquinazoline C (PubMed:33705521). Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.