Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (PubMed:17920017). Acts as component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (By similarity). May be involved in the control of cell growth and differentiation. May have a role in embryonic development. Interacts with GCN5L2 and PCAF (By similarity). The coiled coil C-terminal region interacts with AH receptor nuclear translocator protein (ARNT) and ARNT2 (PubMed:11025203). Interacts with CCDC100/CEP120 (PubMed:17920017). Interacts with CKAP5 independently of clathrin. Interacts with CKAP5 and clathrin forming the TACC3/ch-TOG/clathrin complex located at spindle inter-microtubules bridges; TACC3 (phosphorylated at Ser-347 by AURKA) and CLTC are proposed to form a composite microtubule interaction surface (By similarity). In complex with CKAP5 localized to microtubule plus-ends in mitosis and interphase. In complex with CKAP5 and clathrin localized to inter-microtubule bridges in mitotic spindles. Embryonically expressed. At 9 dpc, the expression is strong in the neuroepithelium of neural tube and in placenta. At 13 dpc, the expression is still observed in neuroepithelium. Furthermore, strong expression is seen in lung, kidney, intestines, thymus and liver, and a moderate signal is detected in the cartilage primordium of developing ribs, tooth and eye. By 17 dpc, the tissue distribution changes so that no signal is detected in the liver and the signal has diminished in other organs. It is observed for the first time in the salivary gland, thyroid gland and brown fat and was strong in the thymus, eye, olfactory epithelium and central nervous system. At 1.5 days after birth, the expression is still strong in thymus, but weaker and more limited in brain. Belongs to the TACC family.