Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis. May play a role as transcriptional regulator (By similarity). Interacts with MYC (via C-terminus), YWHAE and YWHAZ. Predominantly nuclear with some expression also seen in the cytoplasm. Predominantly cytoplasmic when phosphorylated at Thr-166 (By similarity). Phosphorylation at Thr-166 promotes interaction with YWHAE and YWHAZ, dissociation from MYC and sequestration in the cytoplasm. Cdca7 expression is correlated with MYC expression in fibroblasts and is much higher in attached cells tham in non-attached cells.