Transcription factor which acts as a master regulator of biofilm formation (PubMed:15964282, PubMed:17030992, PubMed:16839200, PubMed:20223293, PubMed:19959578, PubMed:20705667, PubMed:21829325, PubMed:21283544, PubMed:21407800, PubMed:22145027, PubMed:22265407, PubMed:22882910, PubMed:22589718). Biofilms play an important role in pathogenesis and produce many infections such as oropharyngeal candidiasis or vulvovaginal candidiasis (PubMed:20705667, PubMed:21283544, PubMed:21407800, PubMed:22544909, PubMed:22265407). Controls the expression of genes that govern cell-surface properties such as ALS1, ALS3, HWP1 AND HYR1 (PubMed:16839200, PubMed:17277173, PubMed:19197361, PubMed:20415594, PubMed:22145027, PubMed:22544909, PubMed:22589718). Down-stream component of the hyphal regulatory network that couples expression of cell-surface genes to hyphal differentiation (PubMed:20223293, PubMed:21407800, PubMed:22359502). Interacts with CBK1. Expression is under the positive control of the hyphal regulator TEC1 and repressed by TUP1 (PubMed:15814840, PubMed:15964282). Also induced by acetic acid-stress in a MNL1-dependent manner (PubMed:18653474). Phosphorylated at Thr-191 and Ser-556 by CBK1. Phosphorylation by CBK1 is required for ALS1 and ALS3 expression, adherence, and biofilm formation. Produces poor biofilms and decreases infection on rat denture models (PubMed:20605982, PubMed:20705667). Increases phagocytosis of the fungus by host cells in presence of estrogen (PubMed:34986357). Decreases expression of GPD2 (PubMed:34986357). Implanted medical devices, such as venous catheters, are a serious risk factor for C.albicans infection since they are substrates for the formation of biofilms, which in turn serve as reservoirs of cells to continually seed an infection.