Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin inhibits human alpha-7/CHRNA7 and alpha-9-alpha-10/CHRNA9/CHRNA10 AChR (complete inhibition at 3 uM of toxin). In addition, this toxin inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (22% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2) (PubMed:26948522). Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/7 pattern. Non-native isomers 'ribbon' (with disulfide connectivity C1-C4; C2-C3) and 'beads' (with disulfide connectivity C1-C2; C3-C4) also inhibit high voltage-activated (HVA) calcium channel currents in rat DRG neurons (20-30% inhibition at 1 uM toxin) (Ref.1). Belongs to the conotoxin A superfamily.