Converts monoacylglycerides to free fatty acids and glycerol (PubMed:30911178). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol (2-AG), and thereby regulates the degradation of endocannabinoid-related monoacylglycerides (PubMed:30911178). Also hydrolyzes arachidonoyl ethanolamide (anandamide, or AEA), but with low efficiency (PubMed:30911178). Plays a role in the regulation of longevity and resistance to oxidative stress (PubMed:30911178). Hydrolyzes glycerol monoesters of long-chain fatty acids. H2O + N-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-ethanolamine = (5Z,8Z,11Z,14Z)-eicosatetraenoate + ethanolamine 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) Inhibited by the benzodioxole 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester (JZL184). Extended lifespan, increased food consumption and increased resistance to oxidative stress induced by paraquat (PubMed:30911178). Increased levels of mono- and polyunsaturated monoacylglycerides, including endocannabinoid 2-arachidonoylglycerol (PubMed:30911178). Lifespan is further extended following treatment with the benzodioxole 4-[bis(1,3-benzodioxol-5-yl)-hydroxymethyl]-1-piperidinecarboxylic acid (4-nitrophenyl) ester (JZL184) (PubMed:30911178). Belongs to the amidase family.