Transcriptional regulator that controls a genetic switch in male development (PubMed:16996051, PubMed:16414182). It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16996051, PubMed:16414182). Involved in different aspects of gene regulation including promoter activation or repression (PubMed:16488877). Binds to the DNA consensus sequence 5'-[AT]AACAA[AT]-3' (By similarity). SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (By similarity). Also involved in pre-mRNA splicing (By similarity). In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (PubMed:16488877). Interacts with CALM, EP300, HDAC3, KPNB1, ZNF208 isoform KRAB-O, SLC9A3R2 and WT1 (By similarity). The interaction with EP300 modulates its DNA-binding activity (By similarity). The interaction with KPNB1 is sensitive to dissociation by Ran in the GTP-bound form (By similarity). Interacts with PARP1; leading to impair its DNA-binding activity (PubMed:16904257). Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization. Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus. Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH). Expressed in the substantia nigra (at protein level). Acetylation of Lys-81 contributes to its nuclear localization and enhances its interaction with KPNB1. Deacetylated by HDAC3. Belongs to the SRY family. The tenuous nature of sex - Issue 80 of March 2007