ADP-ribosylates double-stranded DNA by targeting the N2 amino group of dG residues. Induces apoptosis in a range of human cell lines (PubMed:10971585) (By similarity). May play a role in destroying cells during pupation and/or defense against parasites (By similarity). a 2'-deoxyguanosine in DNA + NAD(+) = an N(2)-(ADP-L-ribosyl)-2'-deoxyguanosine in DNA + H(+) + nicotinamide Belongs to the pierisin ADP-ribosyltransferase family.