D-threo-isocitrate = glyoxylate + succinate acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+) Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 1/2. Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. Intestinal and body wall muscle cells. First detected early in the generation of the clonal E cell lineage that is committed to intestinal development and then increases to maximal levels in actively differentiating intestinal and body wall muscle cells. Highest activity in embryos and falls dramatically during L1 larval development (PubMed:7781887). Expression is highest in L3 larval stage with low levels at other stages (PubMed:21884719). In the N-terminal section; belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family. In the C-terminal section; belongs to the malate synthase family. Chimeric cDNA.