In insects, FMRFamide and related peptides have modulatory actions at skeletal neuromuscular junctions, and peptides that are immunologically related to FMRFamide are released into the circulation from neurohemal organs. RFamide 1: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level). Expression in AL detected in most animals, in CC, CA and in GNG in some animals (at protein level). RFamide precursor-related peptide 2: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level). Expression in AL detected in some animals, expression in CC, CA and GNG in few animals (at protein level). RFamide 3: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level). Expression in AL detected in all animals, in CC, CA and GNG in most animals (at protein level). RFamide 5: Expressed in corpora cardiaca (CC), corpora allata (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level). Expression in AL detected in all animals, in CC, CA and in GNG in some animals (at protein level). RFamide 1. RFamide precursor-related peptide 2. RFamide 3. RFamide 5. Belongs to the FARP (FMRFamide related peptide) family. Further mature peptides might exist.