Involved in the biosynthesis of the anthracyclines carminomycin, rhodomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the incorporation of a hydroxyl group at position C-11 of aklavinone, resulting in epsilon-rhodomycinone. It cannot accept substrates glycosylated at position C-7. It can also hydroxylate 11-deoxycarminomycinone and can use both NAD or NADP. aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+) Antibiotic biosynthesis; daunorubicin biosynthesis. Antibiotic biosynthesis; carminomycin biosynthesis. Antibiotic biosynthesis; rhodomycin biosynthesis. Monomer. Belongs to the PheA/TfdB FAD monooxygenase family.