Blocks infection by several different human immunodeficiency virus type 1 (HIV-1) strains. This occurs because vMIP-II binds to a wide range of chemokine receptors. May form part of the response to host defenses contributing to virus-induced neoplasia and may have relevance to KSHV and HIV-I interactions. Monomer. Interacts with human chemokine receptor CXCR4 (PubMed:25612609). Belongs to the intercrine beta (chemokine CC) family.