Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin (By similarity). Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). Mediates ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). Homodimer (By similarity). Interacts with the transactivation domain of BRCA2 (PubMed:14651845). Interacts with CBX1 (via chromoshadow domain) (By similarity). Interacts with ZMYND11 (By similarity). Does not interact with CBX3 or CBX5 (By similarity). Component of a nuclear receptor-mediated transcription complex composed of at least ZNF335, CCAR2 and EMSY; the complex stimulates the transcription of nuclear receptor target genes such as SOX9 and HOXA1 (By similarity). Within the complex interacts with CCAR2 and ZNF335 (By similarity). Components of this complex may associate with components of a histone methylation complex to form a complex at least composed of ZNF335, HCFC1, CCAR2, EMSY, MKI67, RBBP5, ASH2L and WDR5 (By similarity). Within this complex, interacts with ASH2L and RBBP5 (By similarity). Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.