Bcl-2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Targets several host TIR adapters including MYD88, TIRAP, TRIF and TICAM2 thereby blocking NF-kappa-B and TRIF-mediated IRF3 activation (By similarity). Interacts with host MYD88, TRF4, TICAM2 and MAL. Belongs to the poxviridae A46R protein family.