RNA-binding protein involved in pre-mRNA splicing (PubMed:19641227). Interacts with the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome (PubMed:19641227). Involved in regulating splice site selection (PubMed:19641227). Binds preferentially RNA with A/C rich sequences and poly-C stretches (PubMed:23144703). Interacts with PRPF19 (PubMed:19641227). Interacts with U2AF65 (PubMed:19641227). Ubiquitous. Expressed at high level in skeletal muscle, kidney, heart, brain and liver. The C-terminal part is necessary for the interaction with the PRP19C/Prp19 complex/NTC/Nineteen complex. The KH domains mediate RNA-binding. Interacts with U2AF65. Belongs to the KHDC4 family. Extended N-terminus.