Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions. The physiological role for the icosapeptide has not yet been elucidated. Gly-Lys-Arg at positions 37 to 39 were included by homology with other pancreatic hormone type precursor sequence. Belongs to the NPY family.