Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2) (By similarity). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA (PubMed:24675531). Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth. (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction. Homooligomer; forms homooligomers via its C-terminus (PubMed:26845565). Interacts with histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) (PubMed:24675531). Interacts (via MYND-type zinc finger) with NCOR1 (PubMed:10734313). Interacts (via MYND-type zinc finger) with MGA protein (via PXLXP motif) (PubMed:23372760). Interacts (via MYND-type zinc finger) with EZH2 (PubMed:16565076). Interacts with EMSY and E2F6 (PubMed:15947784, PubMed:16565076). Interacts with PIAS1 and UBE2I (PubMed:19766626). (Microbial infection) Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. (Microbial infection) Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif) (PubMed:11733528, PubMed:26845565). Interacts with Epstein-Barr virus-derived protein LMP1; leading to negatively regulate NF-kappa-B activation by Epstein-Barr virus-derived protein LMP1 (PubMed:12181323, PubMed:16382137, PubMed:19379743, PubMed:20138174). Associates with chromatin and mitotic chromosomes. Ubiquitous. Down-regulated in breast cancer patients with poor prognosis. The PWWP domain specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and adopts a five-bladed beta-barrel fold with an extended C-terminal alpha-helix, with a conserved H3.3K36me3-binding aromatic cage formed by Phe-291 and Trp-294 of the beta1-beta2 loop and Phe-310 of the beta3-beta4 loop. Specific recognition of H3.3 histone is mediated by the encapsulation of the H3.3-specific 'Ser 31' residue in a composite pocket formed by the tandem bromo-PWWP domains. Sumoylated following its interaction with PIAS1 and UBE2I. Ubiquitinated, leading to proteasomal degradation. A chromosomal aberration involving ZMYND11 is a cause of acute poorly differentiated myeloid leukemia. Translocation (10;17)(p15;q21) with MBTD1. The disease is caused by variants affecting the gene represented in this entry. Truncated N-terminus. Truncated N-terminus.