Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity). ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) Binds 3 Mg(2+) ions per subunit. Belongs to the Nudix hydrolase family. NudF subfamily.