Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. Probably involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen. Homodimer. Heterodimer with AKR7A2. By the phenolic antioxidant ethoxyquin. With succinic semialdehyde or 4-nitrobenzaldehyde as substrate, it exhibits a substantially greater specific activity with NADPH than with NADH Conversely, it has a 3-fold higher activity towards 2-carboxybenzaldehyde with NADH than with NADPH. Belongs to the aldo/keto reductase family. Aldo/keto reductase 2 subfamily.