Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. Highly expressed in skin and spleen, and at lower levels in kidney and liver (PubMed:9822685, PubMed:10072771). Also detected in lung and brain (PubMed:9822685). Not detected in lung or brain (PubMed:10072771). In lung, localizes to respiratory epithelia of the bronchi and trachea and the submucosal glands (PubMed:9822685). Glycosylated. The 130-kDa product is autoproteolytically processed by the metalloprotease domain and yields two subunits, a 90-kDa protein and a group of 32- to 38-kDa proteins (PubMed:9822685). The cleavage is necessary for calcium-activated chloride channel (CaCC) activation activity (By similarity). Belongs to the CLCR family.