Involved in the biosynthesis of the anthracyclines carminomycin, rhodomycin and daunorubicin (daunomycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the incorporation of a hydroxyl group at position C-11 of aklavinone, resulting in epsilon-rhodomycinone. It cannot accept substrates glycosylated at position C-7 and is specific for the C-9R configuration of anthracyclines. It can use both NAD or NADP but it is slowly inactivated in the presence of NADH. aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+) Inhibited by phenylglyoxal and 2,3-butanedione. NADP provides a partial protection against inhibition by phenylglyoxal. Increasing the methanol concentration in the assay causes inhibition of the enzyme. Optimum pH is near 7.4. Optimum temperature is 37 degrees Celsius. Antibiotic biosynthesis; daunorubicin biosynthesis. Antibiotic biosynthesis; carminomycin biosynthesis. Antibiotic biosynthesis; rhodomycin biosynthesis. Monomer. Belongs to the PheA/TfdB FAD monooxygenase family.