Causes breakdown of chromosomal DNA as well as complete inhibition of lipid synthesis in sensitive cells. Purified pyocin S2 makes up a complex of the two (large and small) proteins. The large protein, but not the pyocin complex, shows in vitro DNase activity. Pyocins contain N-terminal receptor-binding domain, translocation domain and C-terminal DNase domain. Belongs to the colicin/pyosin nuclease family.