Pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism. The oxidase activity is potentiated by NOXA1 and NOXO1. NOX1, NOXA1, NOXO1, RAC1 and CYBA forms a functional multimeric complex supporting ROS production. Interacts with NOXA1 and NOXO1. Expressed in colon and vascular smooth muscle cells (VSMC). (c-type) induced in VSMC by angiotensin II and injury to the artery. Product of f-type and c-type mRNA, which differ only in 5'-UTR.