Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ. acetyl-CoA + an arylamine = an N-acetylarylamine + CoA There are two forms of NAT2: a rapid/stable isoform (Asn-99) and a slow/unstable isoform (Ile-99). Belongs to the arylamine N-acetyltransferase family.