Involved in the export of mRNA from the nucleus to the cytoplasm. Interacts with NXT1, NXT2, E1B-AP5, the REF proteins and with nucleoporins, Nup62, Nup153 and Nup214. Interacts with LUZP4. Localized in the nucleoplasm and at the nuclear envelope. Shuttles between the nucleus and the cytoplasm. Expressed almost exclusively in testis. Also expressed in several cancers. The NTF2 domain heterodimerizes with NXT1 and NXT2. The formation of NXF1/NXT1 heterodimers is required for NXF2-mediated nuclear mRNA export. The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus. The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF2 to the nuclear rim. The RNA-binding domain is a non-canonical RNP-type domain. Belongs to the NXF family. The sequence differs from that shown due to either intron retention or a splicing event.