Together with wdr-20, binds to and stimulates the activity of the deubiquitinating enzyme usp-46, leading to deubiquitination and stabilization of the glr-1 glutamate receptor. Interacts with usp-46; the interaction increases the catalytic activity of usp-46 in the presence of wdr-20. Expressed in several head neurons and cells in the tail including the anal depressor cell. Changed locomotion behavior with mutants displaying decreased reversal frequencies consistent with decreased glutamergic signaling. Belongs to the WD repeat WDR48 family.