Essential for spermatogenesis and male fertility (PubMed:33144677). May play an important role in sperm head and tail formation (PubMed:33144677). May act as a tumor suppressor by inhibiting cell proliferation (By similarity). Interacts with alpha-and beta-tubulin (By similarity). Interacts with BBS2, BBS4, BBS5, MKKS, TCP1, CCT2, CCT3, CCT4, CCT5 and CCT7 (By similarity). Expressed in germ cells of the testis (at protein level) (PubMed:33144677). Also expressed in the lung and kidney (PubMed:33144677). Expression begins at postnatal day 20 (P20) and reaches a mximum at P25 in the testis (at protein level). Male mice are infertile due to impaired spermatogenesis (PubMed:33144677). Sperms are immotile and show an abnormal head shape and short flagellum, and are often accompanied by an abnormal manchette structure (PubMed:33144677).