Plays a role in the formation of clathrin-coated invaginations and endocytosis. Binds EPS15, AP-2 and clathrin (By similarity). Interacts with UBQLN2 (By similarity). Interacts with ITSN1. In punctate structures throughout the cell and particularly concentrated in the region of the Golgi complex. The NPF repeat domain is involved in EPS15 binding. The DPW repeat domain is involved in AP-2 and clathrin binding. Ubiquitinated. Belongs to the epsin family.