S-adenosyl-L-methionine-dependent O-methyltransferase that methylates at 4-OH of the noviose moiety, the penultimate step in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases. desmethyldescarbamoylnovobiocin + S-adenosyl-L-methionine = descarbamoylnovobiocin + H(+) + S-adenosyl-L-homocysteine kcat is 0.4 min(-1) with demethyldecarbamoylnovobiocin as substrate. Antibiotic biosynthesis; novobiocin biosynthesis. Homodimer. Belongs to the methyltransferase TylF/MycF family.