Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1. Binds to the PRKD1 promoter. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA. Expressed around the blastopore through gastrula stages. Expressed in the neural tube (posterior dorsal neuroectoderm and the posterior ventral ectoderm) at late neurula stage 20. Expressed in the posterior tip of the neural tube and the posterior wall of the neuroenteric canal at tail bud stage 30. Expressed in the developing gut at stage 40. Belongs to the Caudal homeobox family.