Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family. In SLAM signaling may cooperate with Sh2d1a/SAP. Plays a role in regulation of effector functions of natural killer (NK) cells by controlling signal transduction through Cd244/2b4. However, conflicting results are reported which may reflect the use of different strain backgrounds. Proposed to act as an inhibitor of Cd244-mediated NK cell function including cytotoxicity and IFN-gamma production, the latter found also by triggering Klra4 and Klrk1 next to Cd244 (PubMed:16127454). Seems to positively regulate Cd244- and Cd84-dependent NK cell functions implicating Cd244-mediated phosphorylation of Vav1 (PubMed:20962259). Interacts with SLAMF1 (phosphorylated). Interacts with CD244. Interacts with Src kinases HCK, LYN, FYN, FGR and LCK (via kinase domains). Expressed in spleen. Expressed in macrophages, CD8(+) T-Cells and NK cells (PubMed:16425036). Conflictingly found only in NK cells (PubMed:16127454).