Inhibits fibrillization of amyloid-beta peptide during the elongation phase. Has also been shown to assemble amyloid fibrils into protease-resistant aggregates. Binds heparin (By similarity). Forms homodimers and homotrimers. Binds to the fibrillized forms of amyloid-beta protein 40 (beta-APP40) and amyloid-betad protein 42 (beta-APP42). Found associated with beta-APP42 more frequently than with beta-APP40 (By similarity). After proteolytic cleavage, CLAC is secreted. Expressed predominantly in neurons with low levels also detected in heart, testis and eye. Undergoes proteolytic cleavage by furin protease to yield the soluble collagen-like Alzheimer amyloid plaque component. Glycosylated. Hydroxylated on proline and lysine residues.