Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). Catalyzes the deimination of arginine residues of proteins (By similarity). In oocytes, is released during cortical reaction and plays a role in preimplantation cleavage and early embryonic development (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo (PubMed:27545678). H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4(+) Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear. Released extracellularly during the cortical reaction, and remains associated with the blastomeres surfaces as a peripheral membrane protein until the blastocyst stage of development. Highly expressed in oocytes and weakly expressed in other somatic tissues. Phosphorylation at Ser-10, possibly by RSK-type kinases, and Ser-446 creates binding sites for 14-3-3 proteins. The disease is caused by variants affecting the gene represented in this entry. Belongs to the protein arginine deiminase family.