Required for the development of cerebellar granule cells (By similarity). May play a role in the process of maturation of dendritic cells. Expressed in spleen by a variety of myeloid cells including macrophages and dendritic cells (at protein level). Ubiquitously expressed with higher expression in lymphoid tissues. Up-regulated in tolerated allografts. Down-regulated in activated macrophages. Overexpression of Tmem176b alters maturation of bone marrow-derived dendritic cells. Belongs to the TMEM176 family.