Serine protease which preferentially cleaves after arginine residues (PubMed:33520733). Involved in the innate immune response against parasite P.bergei infection by activating the melanization cascade (PubMed:33520733). Probably in the hemolymph, cleaves and activates prophenoloxidase (PPO), which functions in the formation of pigments such as melanin and other polyphenolic compounds (PubMed:33520733). In the susceptible strain G3, appears to be dispensable for ookinete elimination which occurs by lysis (PubMed:33520733). Inhibited by serpin SRPN2. Forms a covalent heterodimer with SRPN2; the interaction inhibits CLIPB10 catalytic activity. The clip domain consists of 35-55 residues which are 'knitted' together usually by 3 conserved disulfide bonds forming a clip-like compact structure. Cleaved by an unknown protease into an active form. RNAi-mediated knockdown in the susceptible strain G3 infected with P.berghei does not affect the numbers of live oocysts and melanized ookinetes in the midgut; however, severely reduces ookinete melanization in a CTL4 RNAi-mediated knockdown background (PubMed:33520733). Simultaneous RNAi-mediated knockdown of SRPN2 and CLIPB10 in female, partially reduces the formation of abdominal melanotic tumors caused by SRPN2 RNAi-mediated knockdown (PubMed:33520733). Belongs to the peptidase S1 family. CLIP subfamily.