Scaffolding protein that assembles DMD and SNTA1 molecules to the basal membrane of kidney cells and liver sinusoids. May function as a repressor of the SYN1 promoter through the binding of repressor element-1 (RE-1), in turn regulates SYN1 expression and may be involved in cell proliferation regulation during the early phase of neural differentiation. May be required for proper maturation and function of a subset of inhibitory synapses. Interacts with dystrophin short form DP71 and syntrophins SNTG1 and SNTG2 (By similarity). Binds DTNBP1 (By similarity). Forms a specific complex composed of DMD, SNTB2 and SNTA1 in neuron; the interaction with SNTB2 and SNTA1 is DMD independent (PubMed:10545507). Interacts with UTRN and dystrophin short form DP71 in the kidney and liver (PubMed:10545507). Interacts with SNTB1, SNTB2 and SNTA1 in kidney and liver. Interacts with KIF5A (PubMed:14600269). Interacts with HMG20A and HMG20B (By similarity). Interacts with OLFM1 (PubMed:17265465). Interacts with PRKAR2B and PRKAR1A (By similarity). Localized at inhibitory synapses on the dendrites of cerebellar Purkinje cells. Expressed in neurons. In the isocortex, expressed most prominently in the somata (including the nuclei) and the dendrites of the pyramidal cells. Expressed in the hippocampus CA1, CA2, and CA3 neurons, namely in the initial segments of dendrites. Expressed in the Purkinje cells, molecular layer interneurons, and granule cells of cerebellum. Expressed in axon fascicles associated with the spinal trigeminal tract and in the internal capsule in the brainstem. The coiled coil domain may mediate the interaction with dystrophin. Phosphorylated by PKA. Phosphorylation at Thr-11 alters the interaction with KIF5A. Belongs to the dystrophin family. Dystrobrevin subfamily.