Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels (By similarity). Cytoplasmic and nuclear in the absence of ligand, nuclear after ligand-binding. Expressed in hippocampus, being restricted to the more superficial cortical layers. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Phosphorylated. Belongs to the nuclear hormone receptor family. NR3 subfamily.