Calcium/calmodulin-dependent protein kinase which phosphorylates cmk-1 (PubMed:10336483, PubMed:10428833, PubMed:12231504). Component of a calcium-triggered signaling cascade involved in CRE-mediated transcriptional activation, probably through cmk-1-mediated crh-1/CREB phosphorylation (PubMed:12231504). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by Ca(2+)/calmodulin (PubMed:10336483, PubMed:10428833). Binding of calmodulin may relieve intrasteric autoinhibition (By similarity). Expressed in head and tail neurons and vulval muscles. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. The RP domain (arginine/proline-rich) is involved in the recognition of substrates such as cmk-1. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.