Insecticidal, cytolytic and antimicrobial peptide (PubMed:18215128, PubMed:27287558). Has insecticidal activity against the flesh fly S.carnaria, and against the cockroach N.cinerea (PubMed:18215128). Has insecticidal activity against D.melanogaster (PubMed:27287558). Has hemolytic activity against human erythrocytes (EC(50)=6 uM) (PubMed:18215128). Has cytolytic activity against insect Sf9 cells (EC(50)=1 uM) and human leukocytes (EC(50)=3 uM) (PubMed:18215128). Has antibacterial activity against the Gram-positive bacteria A.globiformis VKM Ac-1112 (MIC=0.5 uM), and B.subtilis VKM B-501 (MIC=0.6-0.9 uM), and against the Gram-negative bacteria E.coli C600 (MIC=0.5 uM), E.coli DH5alpha (MIC=0.9 uM), E.coli MH1 (MIC=0.5 uM), P.aeruginosa PAO1 (MIC=1.9 uM), and P.fluorescens VKM B-894 (MIC=3.8 uM) (PubMed:18215128, PubMed:27287558). Lacks antimicrobial activity against the Gram-positive bacteria M.luteus and S.aureus, and against the Gram-negative bacterium S.marcescens (PubMed:18215128). Forms voltage-dependent, ion-permeable channels in membranes (PubMed:18215128). At high concentration causes cell membrane lysis (PubMed:18215128). Expressed by the venom gland. Both the N-terminus (61-94) and the C-terminus (99-129) of the mature peptide form alpha-helices which probably disrupt target cell membranes. The linker region (95-98) probably derives from a processing quadruplet motif (PQM), found in propeptides of many zodatoxins, hinting at a fusion of two originally separate membrane-active peptides. Cleavage of the propeptide depends on the processing quadruplet motif (XXXR, with at least one of X being E). LD(50) is 5 ug/g on adult flesh flies (S.carnaria) (PubMed:18215128). LD(50) is 20 ug/g on flesh fly larvae (S.carnaria) (PubMed:18215128). LD(50) is 500 ug/g on cockroachs (N.cinerea) (PubMed:18215128). LD(50) is 12.3 ug/g on D.melanogaster (PubMed:27287558). Belongs to the cationic peptide 06 (cytoinsectotoxin) family.