Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (RARE). (Microbial infection) Isoform 3 interacts with HCV core protein. Found in the nuclear body. Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. By IFNG/IFN-gamma and all-trans retinoic acid (ATRA). Phosphorylated (isoform 2). The disease is caused by variants affecting the gene represented in this entry. SP110 mutation db