This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA. Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.