Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Calcium channel activity is enhanced by MYLK, that promotes its subcellular localization at the plasma membrane. Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts with SLC9A3R1/NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts (via C-terminus) with CABP1 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity). Expressed in brain. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.