Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is not of the classical apoptotic type and regulates expression of components of the plasminogen pathway. Expressed in brain. Weakly expressed in embryonic stem (ES) cells and in ES-derived neural stem cells (NSCs). Expressed from 9.5 dpc. Up-regulated upon differentiation into neuronal cells in the presence of retinoic acid and BDNF. Up-regulated upon differentiation into astroglial cells. Belongs to the BRINP family.