DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. In complex with FANCA, FANCG and FANCL, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins. Viable with no gross developmental abnormalities or significant growth retardation. Gonad defects are present in both male and female mice. Testes are devoid of germ cells. Ovaries show premature depletion of primordial follicles with almost complete loss by 14 weeks of age, and aberrant estrous cycle. Significantly increased incidence of tumors, particularly ovarian tumors.