May play a role in regulating epithelial homeostasis in an ATG16L1-dependent manner. Homooligomer (PubMed:22082872). Heterooligomer with ATG16L2 (PubMed:22082872). Interacts with ATG5 (PubMed:22082872). Self-oligomerizes to form a 800-kDa complex composed of ATG12-ATG5 and ATG16L2 (PubMed:22082872). Interacts with RAB33B (PubMed:22082872). Localizes also to discrete punctae along the ciliary axoneme. Widely expressed. ATG16L2-deficient mice are viable and born at Mendelian proportions. Deficient mice exhibit intact canonical autophagy. Although ATG16L2 is structurally similar to ATG16L1 and is likewise able to form a complex with the autophagy proteins ATG5 and ATG12, overexpression and knockdown studies suggest that ATG16L2 is not essential for canonical autophagy. Belongs to the WD repeat ATG16 family. The sequence differs from that shown because it seems to be derived from a pre-mRNA.