Mediates the export of the majority of mRNAs from the nucleus to the cytoplasm (PubMed:11779805, PubMed:11780633, PubMed:11780634, PubMed:27016737). In ovarian follicle cells, plays a role in transposable element silencing regulation by enabling the nuclear export of flamenco (flam) transcripts and subsequent piRNA biogenesis (PubMed:33856346). Interacts with Nxt1 (PubMed:11780633, PubMed:31570835). Interacts with ZC3H3 (PubMed:19364924). Forms a complex with Nup358/RanBP2, RanGAP and Nxt1 (PubMed:14729961). Interacts with Nup54 and Nup58 (PubMed:33856346). Interacts with Orc3 and Hpr1 (PubMed:27016737). Localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex. Shuttles between the nucleus and the cytoplasm. Expressed ubiquitously. Expressed both maternally and zygotically. Expressed throughout embryonic development. The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus. The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for localization of NXF1 to the nuclear rim. The RNA-binding domain is a non-canonical RNP-type domain. Mutations affect the morphogenesis of embryonic neurons, embryonic muscle and adult sensory bristles. This is thought to be due to reduced rate of protein synthesis as the mRNA is not efficiently being exported out of the nucleus. Belongs to the NXF family.