Involved in RNA export from the nucleus to the cytoplasm. Interacts with nucleoporins, Nup98, Nup153 and Nup214. Shuttle protein that accumulates in the nucleoplasm and at the nuclear rim. The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus. The C-terminal fragment, containing the TAP domain (also called UBA-like domain) and part of the NTF2-like domain, named the NPC-binding domain, mediates direct interactions with nucleoporin-FG-repeats and is necessary and sufficient for its localization to the nuclear rim. The RNA-binding domain is a non-canonical RNP-type domain. Belongs to the NXF family.