Membrane-perturbating peptide with multiple activities (PubMed:34302796). It is insecticidal, since it induces contractile paralysis in insects (L.cuprina) during several hours and death after 24 hours (PubMed:34302796). It shows a relatively strong and broad-spectrum antibacterial activity against both Gram-positive and Gram-negative bacteria (MIC<20 uM) (PubMed:34302796). It is also antiparasitic, since it potently inhibits the larval development of the major pathogenic nematode of ruminants (H.contortus, IC(50)=5.6 uM) and reduces the motility of adult males of the other nematode B.malayi (PubMed:34302796). It also shows cytotoxic activity against HEK293 cells (EC(50)=5-7 uM) but does not induce hemolysis in human erythrocytes (PubMed:34302796). In addition, it causes a moderate increase in intracellular calcium concentration on neuronal and epithelial cell lines, which supports a non-specific membrane perturbation mechanism of action (PubMed:34302796). In vivo, it induces pain by intraplantar injection into mice, suggesting a defensive function against vertebrate predators (PubMed:34302796). Adopts an alpha-helical conformation in membrane-mimetic environments. Expressed by the venom gland. Monoisotopic mass. PD(50) is 0.5 nmol/g 1 hour after injection into L.cuprina. LD(50) is 3.5 nmol/g 24 hours after injection into L.cuprina (PubMed:34302796). In vivo, it induces pain by intraplantar injection into mice, suggesting a defensive function against vertebrate predators (PubMed:34302796). Belongs to the ponericin-G family.