Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). It is apparently involved in transcriptional activation. H2O + N(6)-acetyl-L-lysyl-[histone] = acetate + L-lysyl-[histone] Identified in a Set3C complex with SET3, HST1, SNT1, SIF2, CPR1 and HOS4/YIL112W. Present with 4890 molecules/cell in log phase SD medium. Belongs to the histone deacetylase family. HD type 1 subfamily.