Plays a role in adipogenesis. Strongly expressed in epididymal white and brown adipose tissue with low levels in heart. Strongly up-regulated during adipogenesis. By the PPARG agonist rosiglitazone. Arxes1 and Arxes2 appear to have arisen by retrotransposition of the signal peptidase Spcs3 followed by a segmental duplication event. Belongs to the SPCS3 family.