metalloproteinase that impairs hemostasis in the envenomed animal (By similarity). Shows autoproteolysis dependent on pH and temperature. Does not show hemorrhagic activity. Inhibits platelet aggregation induced by ADP (IC(50) is 200 nM), collagen (IC(50) is 500 nM), thrombin and epinephrin (IC(50) is 300 nM). Does not inhibit aggregation induced by ristocetin. Inhibits platelet aggregation induced by ADP (IC(50) is 100 nM), collagen (IC(50) is 500 nM), thrombin and epinephrin (IC(50) is 300 nM). Does not inhibit aggregation induced by ristocetin. Significantly inhibits angiogenesis both in vivo and in vitro. Binds 1 zinc ion per subunit. Excess of calcium ions significantly suppress the autoproteolysis of the enzyme. Monomer. Expressed by the venom gland. The disintegrins belong to the medium disintegrin subfamily. Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily. The metalloprotease is also encoded by another precursor (AC Q90WC0). Extended C-terminus.