Seems to act as a chloride ion channel (By similarity). Plays a role in retina development (PubMed:30157172). Interacts with mitochondrial protein PIGBOS1 (via C-terminus); the interaction occurs at the mitochondria-associated endoplasmic reticulum (ER) membrane, a zone of contact between the ER and mitochondrial membranes, but does not appear to play a role in ER-mitochondria tethering and is not affected by ER stress (By similarity). Interacts with CALR (By similarity). Within the endoplasmic reticulum (ER), localizes to the mitochondria-associated ER membrane, a zone of contact between the ER and mitochondrial membranes. Embryonic lethal. Belongs to the chloride channel MCLC family.