Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (PubMed:26644582). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (PubMed:26644582). Also required for eye development (PubMed:26644582). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (PubMed:27159997). May be involved in apoptosis regulation (PubMed:12021275). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] Interacts with ABL1 (PubMed:12021275). Interacts with COPS5 (By similarity). Ubiquitously expressed. Lethality one day after birth (PubMed:26644582). Pups and embryos show eye malformation and heart defects (PubMed:26644582). Mice display cardiomyopathy and cardiac defects including bradycardia (PubMed:26644582). Heart defects are characterized by thinner and enlarged ventricular walls, cardiomyocyte disarray and abnormal nucleus morphology (PubMed:26644582). Belongs to the DHHC palmitoyltransferase family.