Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response. Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2P2/p36. In the lamina beneath the plasma membrane. In melanosome fractions from stage I to stage IV. Translocated from the cytoplasm to the cell surface through a Golgi-independent mechanism. A pair of annexin repeats may form one binding site for calcium and phospholipid. It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Belongs to the annexin family. Could be the product of a pseudogene. The existence of a transcript at this locus is supported by only one sequence submission (PubMed:2174397).