Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation. Homodimer. Interacts with AGTR2. Interacts with PTPN6. In neurons, translocates into the nucleus after treatment with angiotensin-II. Ubiquitously expressed, with highest levels in uterus and adrenal gland. Belongs to the MTUS1 family.