Tooth-associated epithelia protein that probably plays a role in odontogenesis, the complex process that results in the initiation and generation of the tooth. May be incorporated in the enamel matrix at the end of mineralization process. Involved in the induction of RHOA activity via interaction with ARHGEF and expression of downstream factors such as ROCK. Plays a role in attachment of the junctional epithelium to the tooth surface. Interacts (via C-terminus) with ARHGEF5. Highly expressed in tooth-associated epithelia. In tooth, it is only detected in the ameloblast layer of the enamel organ, starting at post-secretory transition and extending throughout the maturation stage. Also detected in epithelial cells of the gingiva which bind it to the tooth surface (junctional epithelium) (at protein level). Predominantly expressed in mandible, but also expressed at weak level in nasal and salivary glands, and at much lower level in epididymis. Specifically expressed in ameloblasts during maturation stages. Not expressed in pre-ameloblasts, weakly expressed in secretory ameloblasts, and strongly expressed in maturation-stage ameloblasts as well as in the junctional epithelium attached to the enamel of erupted molars. O-glycosylated. Belongs to the ODAM family.