Seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53. Component of a mSin3A-like corepressor complex, which is probably involved in deacetylation of nucleosomal histones. ING2 activity seems to be modulated by binding to phosphoinositides (PtdInsPs). Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of a mSin3A-like complex at least consisting of SIN3A, HDAC1, HDAC2, RBBP4/RbAp48, RBBP7/RbAp46, SAP30 and ING2. Predominantly nuclear. Localized to chromatin and nuclear matrix. Upon reduced PtdIns(5)P levels seems to be released from chromatin and, at least partially, translocated to the cytoplasm. Widely expressed. Higher expressed in colon-cancer tumor than in normal colon tissues. Induced by the DNA-damaging agents etoposide and neocarzinostatin. The PHD-type zinc finger mediates the binding to H3K4me3. The polybasic region (PBR) is responsive to the binding to phosphoinositides (PtdInsPs), including phosphatidylinositol 5-phosphate (PtdIns(5)P). Sumoylation enhances its association with SIN3A and is required for binding to some target gene promoters, this is the case for TMEM71. Low expression except in testis, where it reaches half of ING2a levels. Belongs to the ING family.