Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of trichosetin, a trans-fused decalin-containing tetramic acid with antimicrobial activity (PubMed:28379186). Directly activates expression of only the three biosynthetic genes PKS-NRPS1, DA and ER, while TF23 and MFS-T are induced by the final product trichosetin and not by TF22 (PubMed:28379186).