Binds to a number of sites in the transcriptional regulatory region of ftz (PubMed:2104801). Isoform beta is required to repress inappropriate segmentation gene transcription and repress genes incompatible with development of photoreceptor cell fates (PubMed:12384587, PubMed:18160715). Probable repressor of the transcription of the segmentation genes ftz, eve, h, odd, run, and en (PubMed:8223261). Inhibits Trl-dependent activation of eve (PubMed:12384587). May bind to the region AGGGC/TGG (PubMed:8247159). Degradation of ttk is directed by binding of sinah or sina, via the adapter molecule phyl which binds to the BTB domain of ttk (PubMed:18160715, PubMed:17962185). A second method of degradation exists that is phyl-independent, this is mediated by recognition of motifs in the C-terminus of ttk (PubMed:17962185). Can form homodimers (PubMed:12384587). Interacts with Trl in vivo via the BTB domain (PubMed:12384587). Interacts with phyl (PubMed:17962185). Interacts with Usp47 (PubMed:18160715). Expressed both maternally and zygotically. Expressed in preblastoderm embryos, followed by complete decay upon formation of the cellular blastoderm when ftz striped expression is at its peak. Polyubiquitinated by sina. Polyubiquitin linkage is mainly through 'Lys-48', but linkage through 'Lys-63' also occurs. Deubiquitination by Usp47 leads to its stabilization. It is uncertain whether Met-1 or Met-3 is the initiator.