May modulate osteogenic differentiation, at least in part, through the bone morphogenetic protein (BMP) signaling pathway, increasing RUNX2 activation and leading to osteoblast commitment and maturation. Expressed during osteogenic differentiation where levels increase from the first days of differentiation and remain high during the whole process (PubMed:30654721). Highly expressed in lung (PubMed:30654721). Up-regulated during osteogenic differentiation. Polyubiquitinated, leading to its degradation via the ubiquitin-proteasome pathway.