Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death. Interacts with HDAC1 (By similarity). Interacts with ATN1. Interaction with ATN1 is improved when the poly-Gln region of ATN1 is extended. Interacts with FAT1. Localized in nuclear bodies of variables size. Colocalized with PML and BAX in nuclear PODs. Additional isoforms seem to exist. Widely expressed. Expressed in tumor cell lines. The interaction with ATN1 is mediated by the coiled coil domain. A chromosomal aberration involving RERE is found in the neuroblastoma cell line NGP. Translocation t(1;15)(p36.2;q24). The disease may be caused by variants affecting the gene represented in this entry.