Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (Probable). Interacts with POUF51 (By similarity). Expressed in brain, kidney, lung and liver. The disease is caused by variants affecting the gene represented in this entry.