Vesicle-associated membrane protein-associated protein (VAP) implicated in maintaining the cortical endoplasmic reticulum (ER)-plasma membrane (PM) attachment (PubMed:23041194, PubMed:26877082, PubMed:29290560, PubMed:32023460). ER-PM contacts function to modulate the distribution of contractile ring components to ensure robust ring assembly (PubMed:26877082). ER-PM contacts function also in controlling exocytosis and maintenance of cell polarity regulating cell shape (PubMed:29290560). VAPs play an important role in regulating eisosome assembly (PubMed:32023460). VAPs also contribute to ER-phagy by tethering atg8 to the ER membrane, but also by maintaining the ER-plasma membrane contact (Ref.7). Interacts with epr1. Localizes at the cortical endoplasmic reticulum-plasma membrane contact sites. The MSP domain is required for binding to the FFAT motif of target proteins. Leads to he dissociation of the cortical endoplasmic reticulum (ER) from the cell periphery and its accumulation in the cytoplasm, in particular in the vicinity of cell tips; when scs2 is also deleted (PubMed:23041194, PubMed:26877082, PubMed:29290560, PubMed:32023460). Affects contractile ring assembly and displays severe cytokinetic defects; when scs2 is also deleted (PubMed:26877082). Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.