Major 5'-3' exoribonuclease involved in mRNA decay. Required for the 5'-3'-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS). Found in a mRNP complex with UPF1, UPF2, UPF3B and XRN1 (PubMed:14527413). Associates with alpha and beta tubulins (By similarity). Interacts with DIS3L2 (PubMed:23756462). Interacts with ZC3HAV1 in an RNA-dependent manner (PubMed:21876179). Interacts with ZFP36L1 (PubMed:15687258). Interacts with TRIM71 (via NHL repeats) in an RNA-dependent manner (PubMed:23125361). Interacts with YTHDC2 (via ANK repeats) (PubMed:29033321). Interacts with DHX34; the interaction is RNA-independent (PubMed:25220460). Discrete foci at the inner surface of the cell membrane. Expressed in heart, brain, pancreas, spleen, testis, osteogenic sarcoma (OGS) biopsy and primary cell lines. By GDNF/glial cell line-derived neurotrophic factor. Down-regulated in OGS biopsy. Belongs to the 5'-3' exonuclease family.