Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes retinyl esters. a carboxylic ester + H2O = a carboxylate + an alcohol + H(+) all-trans-retinyl hexadecanoate + H2O = all-trans-retinol + H(+) + hexadecanoate Belongs to the type-B carboxylesterase/lipase family.