Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to replication in macrophages. Plays a role, cooperatively with SopB, in membrane fission and macropinosome formation during invasion. Secreted via type III secretion systems 1 and 2 (SPI-1 and SPI-2 TTSS), and delivered into the host cell (Probable). Membrane-associated in transfected cells. Recruited to the bacterial invasion site, and this recruitment requires the phosphatase activity of SopB. Deletion of this gene impairs bacterial replication in mouse macrophages but not in human epithelial cells. Belongs to the SopD family.