Cholesterol efflux transporter in macrophages that is responsible for APOAI/high-density lipoproteins (HDL) formation at the plasma membrane under high cholesterol levels and participates in reverse cholesterol transport. May play a role in the processing of autolysosomes. ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate Localized at cell membrane under high cholesterol levels. Expressed in testis, epididymis, lung and brain. N-glycosylated. Belongs to the ABC transporter superfamily. ABCA family.