Cytoskeleton-associated protein (Probable). May play a role in hypodermal cell development (Probable). Expressed in the Y and U rectal epithelial cells, in marginal cells of the terminal bulb and isthmus of the pharynx (at protein level). Expressed throughout development (at protein level). First expressed in two-fold stage embryos (at protein level) (PubMed:12204272). During embryogenesis, expressed in the apical regions of the dorsal and ventral hypodermis in tightly organized circumferential filament bundles (at protein level) (PubMed:12204272). Expressed in seam cells in embryos and at the larval stages (at protein level) (PubMed:12204272). In L1 stage larvae, expressed in the apical junction between hypodermal cells hyp 5, hyp 6 and hyp 7, and between the seam cells and the P blast cells in the ventral midline (at protein level) (PubMed:12204272). In L2 stage larvae, expressed in the Y and U rectal epithelial cells (at protein level) (PubMed:12204272). In L3 stage larvae, expressed in the pharynx, socket cells, the processes that link socket cells to the amphid, in marginal cells of the terminal bulb and at the junction between the pharynx lumen and the hypodermis (at protein level) (PubMed:12204272). In L4 stage larvae, expressed in longitudinal filaments within the cytoplasm linking both extremities of the elongating seam cells and in the alae formed by their fusion (at protein level) (PubMed:12204272). Belongs to the transglutaminase-like superfamily. Unlike the mammalian homolog KY, the residues forming the catalytic triad in the putative transglutaminase-like domain of ltd-1 are not conserved, therefore it is likely that the protein lacks protease activity.