Catalyzes the formation of tuberculosinyl diphosphate from geranylgeranyl diphosphate (GGPP). It could also react with (14R/S)-14,15-oxidoGGPP to generate 3alpha- and 3beta-hydroxytuberculosinyl diphosphate. geranylgeranyl diphosphate = tuberculosinyl diphosphate Strongly inhibited by 15-aza-dihydrogeranylgeraniol and 5-isopropyl-N,N,N,2-tetramethyl-4-(piperidine-1-carbonyloxy)benzenaminium chloride (Amo-1618). Inhibited by GGPP concentrations higher than 50 uM. Optimum pH is 7.5. Enzyme activity is not detected at pH values above 9.0. Optimum temperature is 30 degrees Celsius. Monomer. Belongs to the terpene synthase family.