Ribosome-associated protein required for translational recovery after starvation from stationary phase. May facilitate rapid translation reactivation by stabilizing the recycling-competent state of inactive ribosomes. Associates with translationally inactive ribosomes in the nonrotated state. LSO2 bridges the decoding sites of the small with the GTPase activating center (GAC) of the large subunit. This position allows accommodation of the DOM34-dependent ribosome recycling system, which splits LSO2-containing ribosomes. Under iron-replete conditions, enriched in the nucleus. Under iron-depleted conditions, expressed in both nucleus and cytoplasm. Constitutively expressed. Expression is not regulated by iron unlike the LSO1 paralog. Mild slow-growth phenotype in response to reduced iron levels (PubMed:26450372). Displays global translation defects during recovery from stationary phase with translation of most genes reduced more than 4-fold. Ribosomes accumulated at start codons, were depleted from stop codons, and showed codon-specific changes in occupancy (PubMed:30208026). Belongs to the CCDC124 family.