Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. The C-terminal SOGA 25 kDa form occurs as a monomer. Secreted in primary hepatocyte-conditioned media. Expressed in liver (at protein level). Up-regulated by adiponectin in primary hepatocytes through the insulin signaling pathway. Down-regulated by amino-imidazole carboxamide riboside (AICAR), an AMPK activator that potentiated insulin secretion. Proteolytically cleaved into a C-terminal SOGA 25 kDa form that is detected in plasma (By similarity). Proteolytically cleaved in primary hepatocytes into a C-terminal SOGA 80 kDa form. Belongs to the SOGA family. Extended N-terminus. Extended N-terminus.