Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as fluconazole (FLC), itraconazole (ITC), posaconazole (POS), and voriconazole (VRC). ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out) ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate Expression is induced in the presence of fluconazole (FLC). Does not affect the susceptibility to azoles, but displays slightly lower minimum inhibitory concentrations (MICs) to cycloheximide and higher MICs to rhodamine 6G (R-6G) (PubMed:29378705). Causes further increase in susceptibility toward fluconazole and itraconazole, when AFR1 and MDR1 are also deleted (PubMed:29378705). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.