Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Heterotetramer containing 2 light chains of S100A10/p11 and 2 heavy chains of ANXA2/p36. In the lamina beneath the plasma membrane. A pair of annexin repeats may form one binding site for calcium and phospholipid. It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Belongs to the annexin family. Red velvet - Issue 86 of September 2007