Glycosidase that has specific alpha-N-acetylgalactosaminidase activity. Cleavage of non-reducing alpha-(1->3)-N-acetylgalactosamine residues from human blood group A and AB mucin glycoproteins, Forssman hapten and blood group A lacto series glycolipids. Binds 1 NAD(+) per subunit. The NAD(+) cannot dissociate. Optimum pH is 6.8. Specifically cleaves the blood group A antigen at neutral pH with low consumption of recombinant enzyme. It is therefore a good candidate to participate in the development of universal red blood cells by removing blood group A antigen. Belongs to the Gfo/Idh/MocA family. Glycosyl hydrolase 109 subfamily. The juice of life - Issue 98 of October 2008