May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1, CUL4A and CUL4B. Interacts with KPNA1, KPNB1 and XPO1. It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. Expressed in the brain. Expressed in the brain at 8.5 dpc, 9.5 dpc and 10.5 dpc. The homozygous loop-tail (Lp) mouse has a severe neural tube closure defect, analogous to the craniorachischisis phenotype seen in humans. This gene has been mapped to The Lp critical region. Belongs to the WD repeat DCAF8 family.