May be required for sperm ADAM3 processing and consequential sperm fertilizing ability (PubMed:32499443). In vitro, has an endopeptidase activity (By similarity). Only expressed in uterus tissue (PubMed:20810007). Expressed in the initial segment (IS) of the caput epididymis, the region most proximal to the testis (PubMed:32499443). Knockout male mice lacking OVCH2 are sterile. Belongs to the peptidase S1 family.