Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis. May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II (By similarity). H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Inhibited by sodium orthovanadate and peroxovanadium compounds, and by pentamidine. Interacts with tubulin. Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus (By similarity). Belongs to the protein-tyrosine phosphatase family.