Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Acts in the intestine to regulate both innate immunity by promoting activation of pmk-1 and also stress response and life span by acting as an upstream, negative regulator of the daf-16 transcription factor (By similarity). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domain 1 binds phorbol ester with low affinity. Phorbol-ester/DAG-type domain 2 binds phorbol ester with high affinity and targets the kinase to the cell periphery, enabling phosphorylation and activation by colocalized tpa-1. Both domains 1 and 2 appear to bind DAG with equal affinity so may contribute equally to translocation and activation (By similarity). Translocation to the cell membrane is required for kinase activation. Phosphorylation on Ser-1046 is the dominant regulator of catalysis, phosphorylation on Ser-1050 has a lesser effect. Prolonged phosphorylation results in ubiquitination and degradation (By similarity). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.