Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor. May be involved in dendritic cell and neuron differentiation (By similarity). Interacts with CTNNB1. In neurons, seems to concentrate at axonal growth cone. Perinuclear in neurons (By similarity). Belongs to the NDRG family.