Probable prephenate dehydrogenase that produces 4-hydroxyphenylpyruvate (4HPP) in the novobiocin biosynthesis pathway. Novobiocin is an aminocoumarin family antibiotic that targets bacterial DNA gyrases. NAD(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADH Antibiotic biosynthesis; novobiocin biosynthesis. Belongs to the prephenate/arogenate dehydrogenase family.