Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. Doubling time increases for growth under nonstress conditions, unable to initiate growth at pH 5.0 and under 3.5% NaCl salt stress. Double deletions of yidC2 and SRP (signal recognition particle) components are barely able to grow in the absence of stress. E.coli yidC partially complements this disruption. Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.