Inhibits neuronal cell proliferation by negative regulation of the cell cycle transition. Promotes pituitary gonadotrope cell proliferation, migration and invasion, when overexpressed. May play a role in cell pituitary tumor development. Expressed in the brain. Weakly expressed in embryonic stem (ES) cells. Expressed in ES-derived neural stem cells (NSCs) and neuronal cells. Up-regulated upon differentiation into neuronal cells in the presence of retinoic acid and BDNF. Down-regulated upon differentiation into astroglial cells. Down-regulated in gonadotrope cells by bone morphogenetic protein and retinoic acid. Belongs to the BRINP family.