Involved in the negative regulation of dendrite outgrowth. Homotetramer, and heterotetramer with other DPYS-like proteins. Interacts with DPYSL2, DPYSL3 and DPYSL4 (By similarity). Interacts with MAP2 and TUBB3 (By similarity). Highly expressed in embryonic and early postnatal brain and spinal cord. Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. Lacks most of the conserved residues that are essential for binding the metal cofactor and hence for dihydropyrimidinase activity. Its enzyme activity is therefore unsure.