May act as a GTPase regulator. Controls survival and growth of spinal motoneurons (By similarity). Forms a heteromeric complex with ALS2CL. Interacts with ALS2CL. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Extended N-terminus. ALS genetic mutations db