Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Associated with postsynaptic endosomes in hippocampal neurons. Highest level in central region of the theca of developing follicles (at protein level). Expressed at highest level in brain and testis, at high level in kidney, lung and stroma, low level in spleen and adrenal gland (at protein level). Expressed in most tissue with highest levels in small ovarian follicles, brain and testis. Expressed throughout follicle development with highest level in small white follicles. Expressed in granulosa cells, theca cells and post-ovulatory sacs of developing follicles. An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. Belongs to the endophilin family.