Plays a crucial role in regulating cilia motility in pronephric tubules, cloaca and neural tube. Required for establishing left-right asymmetry of the body plan; controls cell fate and convergent extension (CE) movements during gastrulation, respectively, via the Wnt and the planar cell polarity (PCP) signaling pathways. Required for the proper development of renal glomeruli and tubules. Interacts with dvl2 (PubMed:18539122, PubMed:19395640). Interacts with kur (PubMed:26904945). Localized to cytoplasmic puncta in ciliated cells. In the semicircular canal, localized to kinocilia. Expressed in kinocilia of hair cells. Maternally and zygotically expressed. Expressed in the embryo at the 256- and 512-cell, sphere and epiboly stages. Expressed in ciliated tissues, including Kupffer's vesicle, otic vesicle, pronephric duct and floor plate of the neural tube. Expressed in the floor plate and chordoneural hinge at 24 hpf. Expressed in the anteriormost tubules adjacent to the glomerular region at 36 hpf. Expressed in the pronephric tubules from mid-somitogenesis through 48 hpf. Mutants show development of polycystic kidney disease and left-right (LR) asymmetry defects. Belongs to the tilB family.