Secreted effector that induces necrotic lesions in Nicotiana benthamiana (PubMed:22352720). Interacts with the rice receptor-like kinases (RLKs) BAK1/SERK3 and BKK1/SERK4, inhibits their kinase activity and suppresses INF1-induced pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) in N.benthamiana (PubMed:30584105). Also interacts with the rice receptor-like cytoplasmic kinase (RLCK) BIK1 and inhibits its kinase activity, thereby inhibiting PAMP-induced ROS generation (PubMed:30584105). In PTI, phosphorylation relaying by RLKs and RLCKs is critical for the initiation of downstream signaling (PubMed:30584105). Suppresses R3a/Avr3a-dependent hypersensitive response (HR) cell deat and thus may have additional targets, probably belonging to a kinase family that regulates Avr3a effector-triggered immunity (ETI) (PubMed:30584105). Interacts with the host pattern recognition receptor (PRR)-associated kinases BAK1/SERK3, BKK1/SERK4 and BIK1. The C-terminal region from residues 107 to 136 is important for BAK1/SERK3-binding and the host cell death suppression. Severely compromised the virulence of M.oryzae on rice and barley. Belongs to the NIS1 effector family.