May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1, CUL4A and CUL4B. Interacts with KPNA1, KPNB1 and XPO1. It shuttles between the nucleus and the cytoplasm. Nuclear import is mediated by KPNA1 and KPNB1 under the regulation of nuclear GTPase RAN. Nuclear export to the cytoplasm is XPO1 dependent. The disease is caused by variants affecting the gene represented in this entry. Belongs to the WD repeat DCAF8 family.