Transcription factor that is involved in protection against oxidative stress (PubMed:32667960). Binds to promoter regions of the gliotoxin (GT) biosynthetic genes gliZ, gliF, gliT, gliM, gliA and gtmA (PubMed:32667960). Two related but different DNA motifs (5'-TCGG-3' and 5'-CGGNCGG-3') are specifically enriched among rglT binding sites in GT-inducing conditions (PubMed:32667960). Also indirectly regulates the expression of gliP, gliG, gliH and gliN (PubMed:32667960). Plays a key role in resistance against exogenously-added GT and GT biosynthesis, mainly through the direct regulation of gliT (PubMed:32667960). Furthermore, rglT is important for virulence in chemotherapeutic mice with invasive pulmonary aspergillosis (IPA) (PubMed:32667960). Leads to high sensitivity to allyl alcohol, a compound indicative for potential defects in carbon catabolite repression (CCR), but does not affect growth in non-stress conditions, nor in the presence of 2-deoxyglucose (2DG), an additional indicator for defects in CCR (PubMed:32667960). Leads also to sensitivity to acrolein, menadione and t-butyl hydroperoxide (PubMed:32667960). Abolishes the production of gliotoxin (GT) and accumulates bisdethiobis(methylthio)-gliotoxin (BmGT) (PubMed:32667960). Leads to reduced expression of gliZ, gliT, gliF and gtmA in GT-inducing conditions (PubMed:32667960). Loses all ability to protect itself against exogenously added GT as well and reduces virulence (PubMed:32667960).