Binds to heterochromatin. Does not interact with either methylated or unmethylated DNA (in vitro). Associated with pericentric heterochromatin. Not associated with pericentric heterochromatin. Detected in heart, placenta, liver, skeletal muscle, kidney and pancreas. Both MBD and PWWP domains are necessary for chromocentric localization. The disease is caused by variants affecting the gene represented in this entry. Truncated N-terminus. Extended N-terminus.