High affinity, slow turnover Mn(2+) transporting ATPase, which is required for virulence. Controls the Mn(2+) cytoplasmic quota and is involved in the uploading of Mn(2+) into secreted metalloproteins (PubMed:23482562). Required for tolerance to Zn(2+) and oxidative stress (PubMed:23482562). Plays a crucial role in the ability to resist zinc poisoning in human macrophages (PubMed:21925112). Shows a preference for Mn(2+), but Zn(2+), Co(2+) and Cu(2+) can act as alternative substrates although at slower turnover rates (PubMed:23482562). ATP + H2O + Mn(2+)(in) = ADP + H(+) + Mn(2+)(out) + phosphate Induced by zinc and during infection of human macrophages (PubMed:21925112, PubMed:23482562). Transcriptionally regulated by iron (PubMed:9514635). Deletion of the gene leads to cytoplasmic Mn(2+) accumulation and a decrease in secreted Mn(2+)-bound proteins (PubMed:23482562). Mutant is hypersensitive to zinc and oxidative stress (PubMed:21925112, PubMed:23482562). It exhibits an impaired growth in human macrophages (PubMed:21925112). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.