Dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 v in a highly specific manner (PubMed:16293765). Also binds the signal peptide of VEGFA (PubMed:16293765). May play a role in angiogenesis with a significant role in cardiovascular and neural development (PubMed:16293765). Widely expressed with higher levels in kidney and aorta. At 9.5 dpc, expressed predominantly in the heart, yolk sac mesodermal layer and endothelium, fetal vascular endothelium in the placenta, dorsal aorta, and ependymal layer of the neural tube. Expression that persists at 12.5 dpc, where expression is increased in some hemangioblasts in yolk sac blood islands, as well as more prominent expression in the ependymal layer of the neuroepithelium and in perineural blood vessels. Embryonic lethal at 12.5 dpc. Mice exhibit impaired angiogenesis and dysregulated neuroepithelial development.