Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues. H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Interacts with PSTPIP1. Expressed in brain, colon and several tumor-derived cell lines. Belongs to the protein-tyrosine phosphatase family. Non-receptor class 4 subfamily.