Scaffolding protein involved in the regulation of PKA signaling and anchoring to the actin cytoskeleton integrating signals propagated by cAMP, diacylglycerol and calcium (PubMed:10480936, PubMed:10480937, PubMed:12223401). Contributes to the maintenance and regulation of cytoskeletal structures in germline via PKA-mediated signaling (PubMed:12223401). As part of ethanol response in the glia, mediates ethanol-induced structural remodeling of actin cytoskeleton and perineurial membrane topology by anchoring PKA to the membrane of perineurial glia (PubMed:29444420). In specific tissues such as eye and thorax, promotes N/Notch protein stability by inhibiting Cbl-mediated ubiquitination and lysosomal degradation pathway of N/Notch in a PKA-independent way (PubMed:29309414). In the circadian brain neurons evening cells (E-cells), might have a role in circadian pacemaker synchronization by playing a redundant role in signaling downstream of the G protein-couple receptor Pdfr (PubMed:23929551). Homodimer (PubMed:10480937). Interacts with Cam; interaction is calcium-dependent and is inhibited by PKC-mediated phosphorylation of Akap200 (PubMed:10480937). Interacts with N/Notch; the interaction stabilizes N/Notch protein levels by preventing Cbl-mediated ubiquitination and subsequent lysosomal degradation of N/Notch (PubMed:29309414). Interacts with Pka-R2 (PubMed:10480936, PubMed:10480937). Binds to F-actin; interaction is independent of myristoylation, but is inhibited by Akap200 phosphorylation and Cam binding (PubMed:10480937). Isoform B: Does not bind to Pka-R2 (PubMed:10480936). Detected in the brain in both neurons and glia (including perineurial glia); specifically in the neuronal nuclei in the cortex and synaptic neuropil (at protein level) (PubMed:29444420). Detected in germline cells, somatic follicle cells and outer rim of the ring canals during oogenesis (at protein level) (PubMed:12223401). Isoform A: Detected in the adult (at protein level) (PubMed:10480936). Isoform B: Detected in the adult with higher levels in the head (at protein level) (PubMed:10480936). Isoform A: Detected in all stages of development, with higher levels in the pupae (at protein level) (PubMed:10480936). Isoform B: Detected in all stages of development (at protein level) (PubMed:10480936). By ethanol. Myristoylated; myristoylation promotes accumulation at the cell periphery. Phosphorylated; phosphorylation prevents binding to F-actin and Cam. Viable (PubMed:12223401, PubMed:29309414). Results in extra notal macrochaetae often accompanied by a socket cell (PubMed:12223401). In the eye, results in decreased N/Notch protein levels and ommatidia defects (PubMed:29309414). In all imaginal disks at early larval stages, results in supernumerary scutellar bristles and loss or mispositioned microchaetae (PubMed:29309414). In the wings, results in a blistered phenotype (PubMed:29309414). Females have egg chambers with multinucleate cells with ring canal remnants (PubMed:12223401). RNAi-mediated knockdown in glia or perineurial glia reduces ethanol tolerance and locomotor sensitization possibly by limiting ethanol-induced membrane topology changes; does not affect perineurial morphology; does not affect glia-mediated blood-brain barrier permeability (PubMed:29444420). RNAi-mediated knockdown in neurons does not alter ethanol sedation sensitivity or tolerance (PubMed:29444420). RNAi-mediated knockdown in the pacemaker dorsal lateral neurons (LNDs) results in reduced pigment-dispersing factor receptor (Pdfr)-mediated response in the circadian brain neuron evening cells (E-cells) (PubMed:23929551).