Attaches the virus to host cellular receptor, inducing endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and cell membrane (By similarity). Homotrimer. Interacts with matrix protein (By similarity). Glycosylated and palmitoylated by host. Glycosylation is crucial for glycoprotein export at the cell surface (By similarity). Arg-352 is highly involved in rabies virus pathogenicity. Its mutation dramatically attenuates the virus (By similarity). Belongs to the lyssavirus glycoprotein family.