ABC multidrug transporter involved in the response to azoles such as fluconazole, itraconazole, ketoconazole and voriconazole and contributes to the development of PDR1-dependent azole resistance (PubMed:15673750, PubMed:18312269). Plays a role in biofilm tolerance to fluconazole (PubMed:24645630). Confers also resistance to 4-nitroquinoline-N-oxide (4-NQO) (PubMed:18312269). Expression is increased in clinical azole-resistant isolates, displaying amounts of transcript increasing from 3.3- to 44.3-fold (PubMed:15673750, PubMed:18312269, PubMed:29464833). Expression is controlled by the pleiotropic drug resistance transcription factor PDR1 (PubMed:18312269, PubMed:29464833). Expression is increased during biofilm growth (PubMed:24645630). The expression levels are significantly down-regulated after exposure to the combination of fluconazole and tacrolimus (FK506) (PubMed:25355935). Leads to increased susceptibility to fluconazole (PubMed:18312269). Leads also to increased susceptibility to 4-nitroquinoline-N-oxide (4-NQO) (PubMed:18312269). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.