This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The anchoring of this receptor to the plasma membrane is probably mediated by the palmitoylation of a cysteine residue. Belongs to the G-protein coupled receptor 1 family. Was originally (PubMed:1315051) thought to be a kappa-type opioid receptor and to originate from human. PubMed:8947459 showed that it is a tachikinin receptor and was termed NK-4R. PubMed:11864635 shows that it is from guinea pig and is NK-3R.