Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues. Strongly expressed in the pituitary gland and the brain (in the inner granular and glomerular layers of the olfactory bulb, anterior olfactory nucleus, primary olfactory cortex, Purkinje cell layer of cerebellum, and pineal gland). Low expression in lung and heart. No expression in submandibular gland, thymus, liver, spleen, adrenal, and kidney. Expressed strongly in fetal brain. Three calcium ions are usually bound at the interface of each cadherin domain and rigidify the connections, imparting a strong curvature to the full-length ectodomain.