Potent agonist for both PKR1/PROKR1 and PKR2/PROKR2, and inducer of a potent and long-lasting hyperalgesia. Also potentiates capsaicin-induced TRPV1 current when tested on DRG neurons. At subnanomolar concentrations, this protein both induces potent chemotaxis of macrophages and stimulates LPS-induced production of the pro-inflammatory cytokines IL-1 and IL-12. In vivo, potently stimulates the contraction of the guinea-pig gastrointestinal (GI) smooth muscle (nanomolar concentration) and rabbit aortic rings (PubMed:12628381). Expressed by the skin glands. Belongs to the AVIT (prokineticin) family.