Functions as a positive regulator of TNF-induced NF-kappaB signaling (By similarity). Regulates angiogenesis and cellular metabolism through interaction with PKM (PubMed:27199445). Oligomer. Dimer. Interacts with PKM; regulates angiogenesis and metabolism. Up-regulated upon endothelial differentiation. N-glycosylated. Homozygote knockout Jmjd8 show no obvious phenotype. However, the number of capillaries in muscle tissue is significantly reduced. Truncated N-terminus.