The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This operon may be cryptic in wild-type K12 strains (Probable). When overexpressed using vectors that provide a promoter and ribosome binding site (PubMed:15919996). The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site. Is shorter than orthologs at the C-terminus by about 170 amino acids. Extended N-terminus.