Pleiotropic ABC efflux transporter involved in the basal level of azole susceptibility (PubMed:26933209, PubMed:28080217). Confers resistance to fluconazole and voriconazole (PubMed:26933209). ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out) ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate Expression is induced upon voriconazole treatment (PubMed:12135575, PubMed:15504870). Expression is increased in clinical azole-resistant isolates (PubMed:26933209, PubMed:28080217, PubMed:29124846). Expression is down-regulated by tetrandrine and posaconazole in a synergistic manner (PubMed:28080217). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.