Suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. The P0 protein suppresses local PTGS using its F-box-like domain to mediate destabilization and degradation of the AGO1 protein (By similarity). Interacts (via F-box-like domain) with host AGO1; this interaction targets AGO1 for degradation, and thereby suppresses the silencing function of the latter. Interacts (via F-box-like domain) with host ASK1 and ASK2 (SKP proteins); these interactions are essential for viral pathogenicity. Part of a SCF P0 complex composed of P0 and the host proteins SKP and CUL1 (By similarity). Belongs to the polerovirus P0 protein family.