Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. May also regulate SLC6A3 and SLC6A4 targeting to the plasma membrane hence regulating their activity. In the nucleus, functions as a nuclear receptor coactivator regulating glucocorticoid, androgen, mineralocorticoid and progesterone receptor transcriptional activity. May play a role in the processes of cell growth, proliferation, migration, differentiation and senescence. May have a zinc-dependent DNA-binding activity. Homooligomer (PubMed:16737959). Interacts with PPARG (PubMed:15687259). Interacts with TRAF4 (By similarity). Interacts with CRIP2 (PubMed:15713747). Interacts with HSPB1 (PubMed:11546764). Interacts with ILK (PubMed:16737959). Interacts with LIMS1 and LIMS2 (PubMed:16737959). Interacts with NCK2 (PubMed:10330411). Interacts with NUDT16L1 (PubMed:11805099). Interacts with PAK (PubMed:10330411). Interacts with PTPN12 (PubMed:10092676). Interacts with TCF3 (PubMed:16291758). Interacts with TCF7L2 (PubMed:16291758). Interacts with VCL (PubMed:9858471). Interacts (via LD motif 3) with GIT1 (PubMed:12153727). Also interacts with GIT2 (PubMed:10330411). Forms a complex with ARHGEF7 (PubMed:10330411, PubMed:12153727). Interacts with AR/androgen receptor in a ligand-dependent manner (PubMed:11779876). Interacts with CSK (PubMed:9858471, PubMed:17233630). Interacts with PTK2/FAK1 and PTK2B/PYK2 (PubMed:9422762, PubMed:9756887, PubMed:10330411, PubMed:9858471, PubMed:10649439). Interacts with SLC6A3 (PubMed:12177201). Interacts with SLC6A4 (By similarity). Interacts with NR3C1 (PubMed:10848625). Interacts with SMAD3 (PubMed:14755691). Interacts with MAPK15 (PubMed:16624805). Interacts with SRC (By similarity). Interacts with LYN (By similarity). Interacts with talin (By similarity). Interacts (via LIM zinc-binding domain 2) with CBLC (via RING-type zinc finger); the interaction is direct and enhances CBLC E3 ubiquitin-protein ligase activity (By similarity). Interacts with PARVA (PubMed:11134073). Interacts with PXN (By similarity). Associated with the actin cytoskeleton, colocalizes with stress fibers. Ubiquitously expressed. Higher expression is detected in lung and spleen. Expression decreases during pregnancy in mammary glands. Expressed in all brain areas, with higher levels in cerebellum, prefrontal cortex and hypothalamus. Expressed in smooth muscle, myoepithelial cells and platelets (at protein level). Preferentially expressed in mesenchymal versus epithelial cells (at protein level). First detected in the developing heart tube at 8.0 dpc and then in cardiac, skeletal and smooth muscle during early stages of development. Highly expressed in differentiating gut epithelial cells. Up-regulated during epithelial to mesenchymal transformation. Up-regulated by TGFB1 and hydrogen peroxide. The LIM zinc-binding domains mediate glucocorticoid receptor coactivation and interaction with AR, CRIP2, ILK, LIMS1, NR3C1, PPARG, TCF3, TCF7L2, SLC6A3 and SMAD3. The LIM zinc-binding 2 and LIM zinc-binding 3 domains mediate targeting to focal adhesions and actin stress fibers. The LIM zinc-binding 3 and LIM zinc-binding 4 domains mediate interaction with TRAF4 and MAPK15. The LIM zinc-binding 4 domain mediates interaction with HSPB1, homooligomerization and targeting to the nuclear matrix. The LIM zinc-binding 3 domain mediates interaction with PTPN12. The LD (leucine and aspartate-rich) motif 3 mediates interaction with GIT1 and functions as a nuclear export signal. Phosphorylated by gonadotropin-releasing hormone-activated SRC. Transcripts of the alpha group are more abundantly expressed. Transcripts of the alpha group are more abundantly expressed. Transcripts of the alpha group are more abundantly expressed. Transcripts of the alpha group are more abundantly expressed. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Transcripts of the alpha group are more abundantly expressed. Belongs to the paxillin family. Truncated N-terminus. Wrong choice of CDS. Truncated N-terminus. Wrong choice of CDS.