Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Participates in Wnt signaling regulation, and plays a role in eye and jaw development (PubMed:31402090). Self-associates. Component of the SCF(FBXW11) complex. At 4 days post fertilization (dpf), it is widely expressed in the brain and eyes. There are high levels of expression in the retinal ganglion layer, the inner nuclear layer, the photoreceptor layer, the ciliary marginal zone, jaw mesenchyme, oral epithelia, and pectoral fins. The N-terminal D domain mediates homodimerization. Knockdown of both fbxw11a and fbxw11b results in abnormally developed pectoral fins and heart edema by day 3 post-fertilization (3 dpf). At 5 dpf, knocked-down embryos show periocular edema, small and misshapen eyes, and abnormal development of the jaw.