Involved in the control of the glyoxylate cycle. RamB negatively controls the expression of icl expression during growth on acetate as the sole carbon source. Does not regulate the expression of other genes involved in acetate metabolism. RamB represses its own expression (independently of the available carbon source) and is negatively regulated by PrpR. Cells lacking this gene show an expression level of icl higher than wild-type during incubation with glucose while remaining approximately at the same level than wild-type during incubation with acetate. ramB expression levels are found to be higher in the deletion mutant than in the wild-type during incubation with acetate or glucose. Was identified as a high-confidence drug target. Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family.