May have a role in spermatogenesis (By similarity). May be a regulator of cytoskeletal organization. Isoform 1 interacts with WASL (via WH1 domain), and monomeric and filamentous actin. In hippocampal neurons colocalizes with WASL in the cell body, axons and the growth cone. Detected mainly in brain and at lower levels in heart and lung (at protein level). Also detected in testis but not in kidney, liver or spleen. By aldosterone, corticosterone and RU28362 in hippocampus. By corticosterone and RU28362 in cortex. The response to corticosterone is slow. Does not respond to vibratory stress. May be regulated by both the mineralocorticoid receptor and glucocorticoid receptor. The WH2 domain is found in a number of putative actin-binding proteins. The profilin-binding motif has been implicated in the interaction with profilin and SH3 domains. The KLKR motif is essential for G-actin binding and for actin polymerization. Suppress the growth and endocytosis defect of yeast lacking VRP1 without correcting the actin patch polarization defect. Belongs to the verprolin family.