May be involved in formation of stretch-resistant cell-cell adhesion complexes. Interacts with CTNNB1. Localizes to intercalated disks of cardiomyocytes and in peritubular myoid cells of testis, and colocalizes with CTNNA1 and CTNNA2. Predominantly expressed in heart and testis. Expressed at lower levels in brain, kidney, liver and skeletal muscle. The disease is caused by variants affecting the gene represented in this entry. Belongs to the vinculin/alpha-catenin family.