ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + H(+) + L-phenylalanyl-tRNA(Phe) Heterotetramer; dimer of two heterodimers formed by FARSA and FARSB. The disease is caused by variants affecting the gene represented in this entry. Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.