Involved in EGFR signaling. Interacts with RNF126. Associated with microtubules of the cytoskeleton and mitotic apparatus. Isoform 1 and isoform 2 are coexpressed in placenta, liver, lung, kidney and pancreas. Only isoform 1 is detected in skeletal muscle, brain and heart. Phosphorylated on tyrosine residues. The disease is caused by variants affecting the gene represented in this entry. Found in a critical region of hereditary spastic paraplegia (HSP) SPG14 locus. No causative CCDC50 mutations were found in HSP families. Major isoform.