Alpha-KTx 16.2: inhibits large conductance calcium-activated potassium channels (KCa1.1/Slo-beta4 KCNMA1/KCNMB4). It appears to block channel activity by a simple bimolecular inhibition process. Shows a fast association rate and a slow dissociation rate of binding on rat brain synaptosome (PubMed:18199674). Significantly inhibits voltage-dependent sodium current and voltage-dependent delayed rectifier potassium currents (PubMed:14632928). Significantly inhibits voltage-dependent sodium current (Nav) and voltage-dependent delayed rectifier potassium current. Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). Monoisotopic mass. Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 16 subfamily.