Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis (PubMed:11063737, PubMed:12145310, PubMed:20663892). Participates in sterol transport out of the ER and distribution into plasma membranes (PubMed:20663892). Ubiquitous. Highly expressed in liver and adipose. The disease is caused by variants affecting the gene represented in this entry. When transfected in S.cerevisiae, it can complement the absence of yeast of ARV1 protein, suggesting a conserved role in sphingolipid metabolism. Belongs to the ARV1 family. Contaminating sequence. Potential poly-A sequence.