Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Catalyzes the N- or O-acetylation of various arylamine and heterocyclic amine substrates and is able to bioactivate several known carcinogens (By similarity). acetyl-CoA + an arylamine = an N-acetylarylamine + CoA Belongs to the arylamine N-acetyltransferase family.