May mediate the hydrolysis of some nucleoside diphosphate derivatives. In vitro, uses both ADP-ribose and NADH as substrates; however the relevance of such substrates in vivo is unclear. ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide kcat is 0.06 sec(-1) with ADP-ribose as substrate. Expressed in roots, stems and, at lower level, leaves. Belongs to the Nudix hydrolase family.