The alpha chain of TRAV38-2DV8*01J31*01C*01/TRBV25-1*01J2S3*01C2*01 alpha-beta T cell receptor (TR) clonotype that displays pan-cancer cell recognition via the invariant MR1 molecule. On CD8-positive T cell clone MC.7.G5, likely recognizes tumor-specific or -associated metabolite(s) essential for cancer cell survival, triggering killing of many cancer cell types including lung, melanoma, leukemia, colon, breast, prostate, bone and ovarian cancer cells. Mediates cancer cell cytotoxicity in an HLA-independent manner. Has no reactivity to healthy cells, even stressed or infected by bacteria (PubMed:31959982). Antigen recognition initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell differentiation into effector/memory T cells (By similarity). Disulfide-linked heterodimer with TRBV25-1*01J2S3*01C2*01 beta chain (PubMed:31959982). The alpha-beta TR associates with the transmembrane signaling CD3 coreceptor proteins to form the TR-CD3 (TCR). The assembly of alpha-beta TR heterodimers with CD3 occurs in the endoplasmic reticulum where a single alpha-beta TR heterodimer associates with one CD3D-CD3E heterodimer, one CD3G-CD3E heterodimer and one CD247 homodimer forming a stable octomeric structure. CD3D-CD3E and CD3G-CD3E heterodimers preferentially associate with TR alpha and TR beta chains (via TM domain), respectively. The association of the CD247 homodimer is the last step of TCR assembly in the endoplasmic reticulum and is required for transport to the cell surface (By similarity). Expressed in MR1-restricted CD8-positive T cells. The complementarity-determining region CDR1 confers specificity to the metabolite antigen. The complementarity-determining region CDR2 confers specificity to the metabolite antigen. The complementarity-determining region CDR3 confers specificity to the metabolite antigen. The connecting peptide (CP) domain contributes to the TR-CD3 assembly and signal transduction. The TM domain mediates the interaction with the CD3 subunits. This sequence is an example of a full-length TR alpha chain. Pan-cancer TRAV38-2DV8*01J31*01C*01 TR alpha chain is generated by somatic recombination of variable TRAV38-2DV8 (AC A0JD32) and joining TRAJ31 (AC A0A075B700) gene segments spliced to constant TRAC (AC P01848) gene segment. Chimeric mRNA corresponding to regions V, J and C of T cell receptor (TR) alpha chain.