May promote vascularization of normal and malignant tissues (By similarity). Has low ribonuclease activity (in vitro). Divalent metal ions, such as Cu2+ and Zn2+, may inhibit the ribonucleolytic activity. Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity). Belongs to the pancreatic ribonuclease family.