May function as a regulator of the EGFR pathway. Probable tumor suppressor which may function in cell growth, proliferation and adhesion. Isoform 2 (via its cytoplasmic part) interacts with EZR. Also detected in mitochondrion and endoplasmic reticulum (PubMed:17641538). Isoform 2 is down-regulated in nasopharyngeal carcinoma cells. Isoform 2 is N-glycosylated. Belongs to the TMEM8 family. Extended N-terminus. Contaminating sequence. Sequence of unknown origin in the N-terminal part.