May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution. Interacts with F-actin. Associates with cortical F-actin. Present in kidney tubules and in the vasculature of many tissues (at protein level). Present in the vasculature and in multiple epithelial populations at 10.5 dpc. Present in the cell junctions of the retinal pigmented epithelium at 15.5 dpc (at protein level). The ASD1 domain mediates F-actin binding. Belongs to the shroom family.