May down-regulate the expression of spermatogenesis-associated genes in female germ cells allowing their normal differentiation into oocytes (PubMed:29731491). May act as a Ras-mediated signaling protein in early embryogenesis. Interacts with RALGDS (via Ras-associating domain) (PubMed:16580637). Interacts with HRAS (in GTP-bound form) (PubMed:16580637). In early one-cell embryos, exists only in the cytoplasm and gradually moves to the nucleus at the middle one-cell stage. At the late one-cell and early two-cell stages, higher levels in nucleus than cytoplasm. After the middle two-cell stage, mainly cytoplasmic and completely cytoplasmic after the four-cell stage. Expressed in the ovary, ovulated oocytes and preimplantation embryos (at protein level). Not detected in testis, liver, kidney, spleen, heart, lung and brain. Expressed predominantly in oocytes and one- to four-cell-stage embryos with weak expression in morula/blastocyst-stage embryos (at protein level). Expression increases from oocyte to the one-cell stage and then decreases toward the four-cell stage (at protein level). Highly expressed in oocytes of primary, secondary and antral follicles with low levels in oocytes of primordial follicles (at protein level). Expression of spermatogenesis-associated genes including Klhl10, Tekt2, Tdrd6 and Tnp2 are significantly up-regulated in the ovaries. Belongs to the PRAME family. Truncated N-terminus.