Transcriptional corepressor. Functions with ripply2.2/bowline to down regulate transcription of tbx6-dependent gene expression. Represses transcription of siamois and nodal3. Interacts with tcf7, tcf7l1, ripply2.2/bowline, dscr6/ripply3 and foxd3. Associates with tbx6 in the presence of ripply2.2/bowline. Interacts with EFNB1 through the SP domain. Expressed at high levels in the spleen and ovary. Expressed maternally. At end of gastrulation, expressed in the prospective neural plate region. In neurula stages, shows highest expression in the sensorial layer of the neurectoderm, decreasing from anterior to posterior. Shows localized expression within the anterior neural plate, including the floor of the neural groove. Expressed in the cement gland anlage at stage 14. At stage 16, expressed in the neural groove, rhombomeres, forebrain and branchial arches. At stage 22, abundant in the eye vesicles, ear placodes, prospective branchial arches, pronephric anlage, prospective pronephric duct, presomitic mesoderm and the somites. In the developing brain, expression is dynamic, being most abundant in the mesencephalon and posterior rhombencephalon. At stage 30, expressed in cephalic ganglia V and VII and in stage 35, also IX and X. Also expressed in the future endocardium and pericardium. At stage 32, expressed in the neural groove, rhombomeres, forebrain and branchial arches. At stage 35, expressed in the future choroid plexus of the telencephalon and in the ependymal layer. Throughout the neural tube, expressed in a dorsal to ventral gradient. In the developing eye, expressed in the prospective ganglion cell layer, the ciliary marginal zone and the lens. WD repeat Groucho/TLE family members are characterized by 5 regions, a glutamine-rich Q domain, a glycine/proline-rich GP domain, a central CcN domain, containing a nuclear localization signal, and a serine/proline-rich SP domain. The most highly conserved are the N-terminal Q domain and the C-terminal WD-repeat domain. The SP domain is involved in EFNB1-binding. Ubiquitinated by XIAP/BIRC4. Belongs to the WD repeat Groucho/TLE family. It is uncertain whether Met-1 or Met-8 is the initiator.