Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against insects (para/tipE). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). PD(50) is 130 ng/g body weight to blowfly larvae, PD(50) is 50 ng/g body weight to locusts (Locusta migratoria). Not toxic by subcutaneous injection into mice. Does not affect the mammalian Nav1.2/SCN2A sodium channel. Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.