Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (By similarity). Binds DNA as a monomer (PubMed:10331876). Interacts with GADD45GIP1. Interacts with STK11 (By similarity). Interacts with IFI27 (By similarity). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (By similarity). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (By similarity). Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27. Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (By similarity). Expressed in lung, brain and superior cervical ganglia. High levels are seen in the adrenal tissue. By nerve growth factor and during liver regeneration. Phosphorylated at Ser-350 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli (By similarity). Phosphorylation of Ser-350 results in decrease in NBRE binding while phosphorylation of Ser-340 has little effect on it. Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity). Belongs to the nuclear hormone receptor family. NR4 subfamily.