Receptor for prostaglandin E2 (PGE2) (PubMed:8119961). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal urine volume and osmolality (By similarity). Interacts (via C-terminus) with MKLN1. Additional isoforms seem to exist. In the kidney cortex and medulla, adrenal gland and stomach. In kidney, expression is higher in tubules in the outer medulla, with lower levels in cortex. In kidney cortex, expression is restricted to distal tubules. Belongs to the G-protein coupled receptor 1 family.