Transcriptional coactivator which is the critical downstream regulatory target in the Hippo/SWH (Sav/Wts/Hpo) signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:16096061, PubMed:18313299, PubMed:22615583, PubMed:27462444). The core of this pathway is composed of a kinase cascade wherein Hippo (Hpo), in complex with its regulatory protein Salvador (Sav), phosphorylates and activates Warts (Wts) in complex with its regulatory protein Mats, which in turn phosphorylates and inactivates the Yorkie (Yki) oncoprotein (PubMed:16096061, PubMed:19900439). The Hippo/SWH signaling pathway inhibits the activity of the transcriptional complex formed by Scalloped (sd) and Yki and the target genes of this pathway include cyclin-E (cycE), diap1 and bantam (PubMed:16096061, PubMed:18313299). Regulates the expression of G1/S-specific CycE and diap1, thereby promoting cell proliferation and inhibiting apoptosis (PubMed:18313299). Required for transcriptional activity of sd in wing imaginal disks (PubMed:18313299). Induces expression of expression of vestigial (vg) in wing and haltere disks and the expression of transcription factor E2f (E2f) (PubMed:18313299). Interacts (via WW domains) with wts (PubMed:16096061). Interacts (via N-terminus) with sd (via C-terminus) and this interaction enhances the transcriptional activity of sd (PubMed:18313299). The phosphorylated form interacts with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Interacts with Ack and ex (PubMed:27462444). Predominantly cytoplasmic (PubMed:18313299, PubMed:18256197, PubMed:19900439). sd promotes its nuclear localization (PubMed:18313299). 14-3-3epsilon, 14-3-3zeta and wts inhibit its nuclear localization (PubMed:18256197, PubMed:19900439). Its activity is regulated by multiple phosphorylation events (PubMed:16096061, PubMed:18256197, PubMed:19900439, PubMed:31857346). Phosphorylation at Ser-88, Ser-145 and Ser-227 negatively regulate its activity and restrict its nuclear localization (PubMed:19900439). Wts-mediated phosphorylation at Ser-145 promotes interaction with 14-3-3epsilon and 14-3-3zeta (PubMed:18256197). Phosphorylation at Ser-88 and Ser-227 regulate nuclear localization and activity independent of 14-3-3 association (PubMed:19900439). Phosphorylation at Ser-146 by Cdk7 promotes its stability by preventing ubiquitination by the DCX(DCAF12) complex (PubMed:31857346). Ubiquitinated by the DCX(DCAF12) complex, leading to its degradation (PubMed:31857346). Phosphorylation at Ser-146 by Cdk7 prevents ubiquitination by the DCX(DCAF12) complex (PubMed:31857346). Named for its loss-of-function phenotype after a very small breed of dog, the Yorkshire Terrier. Belongs to the YAP1 family. Extended N-terminus. Extended N-terminus. Extended N-terminus. Extended N-terminus.