Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6. H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide Interacts with Tsi6, VgrG1a, EagT6 and EF-Tu.