Structural components of the gap junctions. Essential for proper epithelial development of the epidermis. Heterooligomer of Inx2 (via cytoplasmic C-terminal region) and Inx3 (via cytoplasmic C-terminal region). In ovary, localizes to the lateral membrane of follicle cells covering the oocyte and to the apicolateral membrane of follicle cells covering the nurse cells. In nurse cells, localizes to the membrane and around the nuclei. In ovary, expressed in nurse cells and follicle cells. Expressed in embryonic epithelial cells. Ubiquitously expressed in stage 5 embryos. Expressed in foregut and hindgut from stage 11-17 and in proventriculus, epidermis and CNS in stage 16 embryos (at protein level). Expressed in anterior and ventral regions in stage 8 embryos. Repeating epidermal pattern emerges at stage 11, refines to one or two cells at each side of the segment borders by stage 13. Expressed in the imaginal wing disk. In pupae, expressed in the CNS and in secondary and tertiary pigment cells of the retina. Expressed during embryogenesis (at protein level). Expressed in larvae and pupae. Belongs to the pannexin family.