Involved in actively transporting phosphate into cells via Na(+) cotransport. 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in) 3 Na(+)(out) + phosphate(out) = 3 Na(+)(in) + phosphate(in) Optimum pH is 6.6. Localized at the brush border membranes of enterocytes. Highly expressed in lung. Also detected in pancreas, kidney, small intestine, ovary, testis, prostate and mammary gland. In lung, it is found in alveolar type II cells but not in bronchiolar epithelium. Down-regulated by EGF. The disease is caused by variants affecting the gene represented in this entry. A chromosomal aberration involving SLC34A2 is found in a glioblastoma multiforme cell line U-118MG. Results in the formation of a SLC34A2-ROS1 chimeric protein that retains a constitutive kinase activity. Belongs to the SLC34A transporter family. Truncated N-terminus.