Voltage-gated chloride channel (PubMed:8112288, PubMed:9122265, PubMed:12456816). Plays an important role in membrane repolarization in skeletal muscle cells after muscle contraction. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (Probable). The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). 2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in) Homodimer. Predominantly expressed in skeletal muscles. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the chloride channel (TC 2.A.49) family. ClC-1/CLCN1 subfamily.