Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Interacts with BSND. Recruited to the plasma membrane in the presence of BSND protein, whereas remains in the Golgi in its absence. Expressed predominantly in the kidney. Expressed in all segments of the nephron examined, including the S2 segment and the glomerulus. Expression is consitently weaker in the absence of BSND protein expression than it is in its presence. The half-life with BSND protein is much longer than that without it. Rapidly degraded without BSND protein, exhibiting a very short half-life of less than 1 hour. Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.