Involved in the biosynthesis of the anthracycline aclacinomycin which is an aromatic polyketide antibiotic that exhibits high cytotoxicity and is widely applied in the chemotherapy of a variety of cancers. Catalyzes the removal of the methoxy group from the C-15 position of aclacinomycin T and A to yield 15-demethoxyaclacinomycin T and A, respectively. aclacinomycin T + H2O = 15-demethylaclacinomycin T + methanol Optimum pH is 7.5. Optimum temperature is 37 degrees Celsius. The activity at 30 and 45 degrees Celsius is 58% and 87% of the optimal activity, respectively. Exceptionally high temperature stability. Antibiotic biosynthesis; aclacinomycin biosynthesis. Monomer. Belongs to the AB hydrolase superfamily. Hydrolase RdmC family.