Inactivates MAP kinases. Has a specificity for the ERK family (By similarity). Plays an important role in alleviating acute postoperative pain (PubMed:24155322, PubMed:28405172). Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (PubMed:24155322). Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain (PubMed:28405172). H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate Interacts with MAPK1/ERK2. Up-regulated in local wound tissue 5-7 days after surgical incision. Mice exhibit a persistent state of mechanical allodynia following plantar incision (PubMed:24155322, PubMed:28405172). This allodynia phenotype is concurrent with long-lasting spinal phosphorylation of MAPK1/3 and MAP kinase p38 (PubMed:24155322). Tissue at the local incision site also shows prolonged expression of phosphorylated MAPK1/3 which persists through to post-operative day 12, although levels of phosphorylated MAP kinase p38 are normal (PubMed:28405172). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.