Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. Associates with the pre-60S ribosomal particle (PubMed:20083226). Interacts with MINAS-60 (product of an alternative open reading frame of RBM10) (PubMed:35393574). Shuttles between the nucleus and the cytoplasm. Belongs to the universal ribosomal protein uL10 family.