May have oxidoreductase activity. Binds to mononucleosomes. Interacts with male-specific lethal (MSL) histone acetyltransferase complex at least composed of mof, msl-1, msl-2 and msl-3. Localization to open chromatin depends on H3K36 trimethylation by Set2. The PWWP domain is a H3 reader and strongly binds DNA. In the dehydrogenase domain, the conserved NAD(P)H-binding sites and sequence similarity to plant dehydrogenases suggest that this protein may have oxidoreductase activity. However, since the active site is not conserved, the dehydrogenase domain seems to serve as a catalytically inert oligomerization module. Belongs to the HIBADH-related family. NP60 subfamily.