Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin inhibits rat Cav2.2/CACNA1B calcium channels in a dose-dependent manner (EC(50)=2.8 uM), whose effect is partially reversed after washing. In vivo, when injected into mice, it shows both an analgesic effect in acute thermal pain at 30 and 45 minutes post-injection and an anti-nociceptive effect in a formalin chronic pain test. Expressed by the venom duct. The cysteine framework is XXVI (C-C-C-C-CC-CC). Contains 4 disulfide bonds. The framework of this peptide is described as framework XXIV but this framework name was already attributed to another cysteine pattern (see AC J7JU64). The framework is therefore renamed to the lowest available number, XXVI, and the peptide is consequently renamed RsXXVIA.