Excitatory insect beta-toxins induce a spastic paralysis (PubMed:32442468). They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). In vivo, this recombinant protein is lethal to Locusta migratoria larvae after injection, but has no significant effect when orally administered. Is not toxic to mice after intracerebroventricular injection (PubMed:32442468). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). LD(50) is 0.4 ug/100 mg of insect (after 48 hours) and 0.2 ug/100 mg of insect (after 72 hours) by injection into Locusta migratoria larvae. Could be considered as a biological insecticide candidate, when fused to Galanthus nivalis agglutinin (GNA), a protein with the potential to cross the insect gut. This chimeric OdTx12/GNA variant shows a gain in toxicity against insects when administered orally, while maintaining similar effects as the wild-type toxin when injected (toxic to insects and non-toxic to mammals). Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.