Receptor for neuromedin-B (By similarity). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (PubMed:26855425). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (PubMed:34133943). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (PubMed:34133943). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (PubMed:30734045). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (PubMed:31601264). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (PubMed:28780306). Expressed in a subset of neurons of the pre-Botzinger complex (PubMed:26855425). Within the pre-Botzinger complex, there is some overlap with neurons expressing Grpr with some cells expressing only Grpr or Nmbr while some cells express both (PubMed:26855425). Expressed in dorsal root ganglion neurons and mast cells (PubMed:30734045). Expressed in lung (PubMed:31601264). During osteoclast development, expression is abundant in early osteoclast precursor cells, decreases as the cells differentiate and is almost absent in mature osteoclasts. Up-regulated in lung tissue in response to infection with influenza A virus. Reduction in rate of basal sighing without affecting the respiratory rate (PubMed:26855425). Significantly reduced sneezing responses to chemical and allergen stimuli (PubMed:34133943). Belongs to the G-protein coupled receptor 1 family.