Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family (PubMed:23161544). Catalyzes the conversion of matairesinol to pluviatolide (PubMed:23161544). (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] kcat is 7.8 min(-1) with (-)-matairesinol as substrate. Aromatic compound metabolism; phenylpropanoid biosynthesis. Belongs to the cytochrome P450 family.