ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. In this organism, this protein is encoded by a gene, located in 'H circle', a 68 kb duplex DNA circle containing a 30 kb inverted repeat. Acquired resistance to methotrexate in the organism is associated with the amplification of h circles with increasing level of LTPGPA gene transcription. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.