Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs) (By similarity). SPT20 plays a role in nuclear division and regulates hyphal and biofilm formation, which are crucial steps for virulence. Component of the SAGA complex. Expression is down-regulated by flucytosine and upon adherence to polystyrene. Impairs proper nucleus dividing and distribution to the dividing cells. Leads to hypersensitivity to amphotericin B, fluconazole and caspofunginreduced; and to reduced virulence in the C.elegans and the G.mellonella infection models. Belongs to the SPT20 family.