NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal. Plays a role in the regulation of cardiac and skeletal muscle metabolic functions. Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal. Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes. Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid. all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. Expressed in skeletal muscle, cardiac muscle and skin. Expression in cardiomyocytes is higher in adult as compared with neonatal. Repressed by adrenergic agents (phenylephrine, isoproterenol, dobutamine and clenbuterol), forskolin and phorbol myristate acetate (at transcriptional levels) (PubMed:22143674). No change in expression with endothelin-1 (PubMed:22143674). The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. Belongs to the short-chain dehydrogenases/reductases (SDR) family.