May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET (By similarity). H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Phosphorylated on serine and threonine residues near the N-terminus by casein kinase II (CK2). Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily.