Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This alpha-like toxin is highly toxic to mice and insects. Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). LD(50) is 1.15 ug/kg (23 ng/mouse) by intracerebroventricular injection into mice. LD(50) is 19.7 nmol/g to cockroaches (Blattella germanica). Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.