Inhibits CASP1/caspase-1-dependent IL1B secretion. Directly interacts with CASP1 and IL1B. Expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. Not detected in skeletal muscle. By bacterial lipopolysaccharides (LPS) and IL1B/interleukin-1 beta in peripheral blood mononuclear cells. The disease is caused by variants affecting the gene represented in this entry. Belongs to the NLRP family. Repertory of FMF and hereditary autoinflammatory disorders mutations