Is probably involved in the catabolism of alpha-glycosides accumulated via a phosphoenolpyruvate-dependent phosphotransferase system (PEP-PTS). Hydrolyzes a wide variety of 6-phospho-alpha-D-glucosides including the five isomeric derivatives of sucrose, i.e. trehalulose-6'-phosphate, turanose-6'-phosphate, maltulose-6'-phosphate, leucrose-6'-phosphate, and palatinose-6'-phosphate, but is not active on sucrose-6-phosphate. Can also hydrolyze maltose-6'-phosphate and methyl-alpha-glucose-6-phosphate, and poorly, trehalose-6-phosphate. Fails to hydrolyze beta-O-linked phosphorylated disaccharides such as cellobiose-6'-phosphate and gentiobiose-6'-phosphate. Does not seem to be involved in maltose catabolism. alpha-maltose 6'-phosphate + H2O = D-glucose + D-glucose 6-phosphate Binds 1 divalent metal ion per subunit. Mn(2+) is the most efficient metal, but can also use Co(2+), Ni(2+) and Fe(2+), and to a lesser extent Mg(2+). Cannot use Zn(2+). Binds 1 NAD(+) per subunit. Is inhibited by EDTA in vitro. Homodimer. May also form homotetramer. By maltulose, leucrose and palatinose, but not by maltose, glucose or sucrose. Belongs to the glycosyl hydrolase 4 family.