NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate. (S)-malate + NAD(+) = CO2 + NADH + pyruvate H(+) + oxaloacetate = CO2 + pyruvate Divalent metal cations. Prefers magnesium or manganese. Subject to allosteric activation by fumarate. Homotetramer. This isoenzyme can also use NADP(+) but is more effective with NAD(+). Belongs to the malic enzymes family.