Involved in microtubule stabilization in many cell types, including neuronal cells (PubMed:8700896, PubMed:9660871, PubMed:3456161, PubMed:11413126, PubMed:28521134). Specifically has microtubule cold stabilizing activity (PubMed:3456161). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (By similarity). Regulates KIF5A-mediated axonal cargo transport (PubMed:28521134). Regulates axonal growth during neuron polarization (PubMed:28521134). Interacts with calmodulin (via C-terminus); the interaction is dependent on Ca(2+) (PubMed:8700896, PubMed:11413126). Interacts with TMEM106B (By similarity). Interacts with ZDHHC13 (via ANK repeats) (By similarity). Interacts with ZDHHC17 (via ANK repeats) (By similarity). Isoform 1 and isoform 2 associate with axonal microtubules in neuronal cells (PubMed:8700896, PubMed:9660871). Localizes predominantly in the proximal part of the axon (PubMed:28521134). Preferentially concentrated on a portion of the microtubule polymer in which tubulin is modified by detyrosination and acetylation and is also resistant to depolymerization induced by both nocodazole and cold (PubMed:9660871, PubMed:14724383, PubMed:28521134). In unpolarized neurons, localizes to the Golgi and to secretory vesicles accumulating transiently at the tips of a subset of neurites (PubMed:28521134). Following neuronal polarization and during axon outgrowth, accumulates in the axonal growth cone and subsequently localizes throughout the axon (PubMed:28521134). Partially localizes to dendrites in mature neurons (PubMed:28521134). Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. At E17.5, expressed in brain including hippocampus and corpus callosum (PubMed:28521134). Isoform 1: Expression begins after birth at P1-P5 stages and is maintained in adults (PubMed:9660871, PubMed:28521134). Expressed in mature neurons (PubMed:28521134). Isoform 2: Expressed at E13, E16 and E18 stages (PubMed:9660871, PubMed:28521134). Expression is increased at P1-P5 stages and persists at low levels in the adult brain (PubMed:9660871, PubMed:28521134). Expressed in unpolarized hippocampal neurons and throughout neuronal development (PubMed:28521134). Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon. Belongs to the STOP family. Contaminating sequence. Potential poly-A sequence.