Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Interacts with FEM1A. Abundant expression in ileum, thymus and mastocytoma P-815 cells. Also observed in lung, spleen, heart and uterus. Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. Belongs to the G-protein coupled receptor 1 family. Was originally designated as the EP2 subtype.