Ion channel involved in sensing mechanical pain (PubMed:32084332). Contributes to mechanosensitive currents in nocireceptors and detecting mechanical pain stimuli (PubMed:32084332). May also be required for efficient adipogenesis (PubMed:26024229). Homooligomer and heterooligomer with TMEM120B. Widely expressed, with higher expression in the heart, kidneys, colon and sensory neurons of the dorsal root ganglia (PubMed:32084332). Expressed in nociceptors (PubMed:32084332). Highly expressed in white adipose tissue (at protein level) (PubMed:26024229). Highly expressed in brown adipose tissue and expressed at low levels in liver (PubMed:26024229). Up-regulated during adipocyte differentiation. Embryonic lethality (PubMed:32084332). Conditional knockout in nociceptors decreases the mechanosensitivity of nociceptors and reduces behavioral responses to painful mechanical stimuli but not to thermal or touch stimuli (PubMed:32084332). TACAN means movement in Farsi. Belongs to the TMEM120 family.