May function as a homophilic cell adhesion molecule and be essential for tight junction integrity. May also be involved in transepithelial migration of leukocytes through adhesive interactions with jaml. The interaction between both receptors may also mediate the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair (By similarity). Monomer. Probably homodimer formed by 2 molecules on adjacent cells (By similarity). The Ig-like C2-type 1 domain may mediate homodimerization.