Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase. Expression is cell-cycle dependent. Undetectable in interphase and prophase, strong expression at the spindle pole throughout metaphase to telophase. The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). The disease is caused by variants affecting the gene represented in this entry. Belongs to the CKAP2 family.