Plays a role in sarcomere organization and in smooth muscle cell contraction. Required for normal development of the embryonic cardiovascular system, and for normal septation of the heart outflow tract. Plays a role in sprouting angiogenesis and is required for normal adhesion of vascular smooth muscle cells to endothelial cells during blood vessel development. Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis. Plays a role in the establishment of cell polarity, cell adhesion, cell spreading, and directed cell migration. Interacts with TGFB1I1 (PubMed:11134073). Interacts with LIMS1 (via LD motifs) (By similarity). Interacts with ARHGAP31 (PubMed:16860736). Interacts with the actin cytoskeleton (PubMed:11134073). Interacts (via C-terminus) with ILK (By similarity). Interacts (via C-terminus) with TESK1 (via C-terminus); the interaction inhibits TESK1 kinase activity (By similarity). Interacts with PXN/PAXILLIN (via LD motif 4) (PubMed:11134073). Constituent of focal adhesions. Embryonic lethality, due to severe cardiovascular defects causing whole body edema and severe bleeding due to vessel rupture. Embryos show defects in the septation of the heart outflow tract. Their cardiomyocytes are round and fail to align in a parallel manner. Blood vessels are frequently enlarged and show numerous microaneurisms. Besides, blood vessels show abnormal constrictions and increased vascular sprouting. Vascular mural cells and pericytes display a rounded shape and impaired adhesion to the underlying vascular endothelium. Cells display highly dynamic formation of membrane ruffles with increased random motility, but impaired chemotaxis. Belongs to the parvin family.