Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation. Interacts with VIM and HINT1. Interacts with IKBKG/NEMO. Interacts with STING1. Colocalizes with intermediate filaments. Absence of TRIM29 enhances macrophage production of type I interferons and protects mice from infection with influenza virus. Truncated N-terminus.