ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate, aspartate and cysteine residues on target proteins (By similarity). Acts as a negative regulator of AHR by mediating mono-ADP-ribosylation of AHR, leading to inhibit transcription activator activity of AHR (Probable). L-aspartyl-[protein] + NAD(+) = 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + nicotinamide L-glutamyl-[protein] + NAD(+) = 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + nicotinamide L-cysteinyl-[protein] + NAD(+) = H(+) + nicotinamide + S-(ADP-D-ribosyl)-L-cysteinyl-[protein] Interacts with AHR. Ubiquitously expressed. By 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a by-product of industrial processes and an important environmental contaminant (PubMed:11716501, PubMed:12147270). This induction is concentration and time-dependent and is mediated through an aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocation (Arnt) signal transduction (PubMed:11716501, PubMed:12147270). Superinduced by cycloheximide and by inhibitors of the 26S proteasome (PubMed:11716501, PubMed:12147270). Auto-mono-ADP-ribosylated. Belongs to the ARTD/PARP family.