Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain (PubMed:21118806, PubMed:21251984). In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (PubMed:23275615, PubMed:30656220). Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating in the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (PubMed:24854278, PubMed:18606867). Plays a role in the proximal tubule function by regulating its endosomal acidification (PubMed:16107722). May play a role in postnatal kidney development (PubMed:18701606, PubMed:23486012, PubMed:27582095). Homodimer; disulfide-linked (PubMed:16107722, PubMed:21118806). Can also form homomultimer (PubMed:21118806). Localizes mainly to the periphery of lipid droplets. it accumulates partly in mitochondrial-associated endoplasmic reticulum membranes. Highly expressed in the S1 proximal tubule segment, (PubMed:23486012). Expressed in the testis, kidney, and liver. Weakly expressed in the heart, brain, and muscle. Highly expressed in the testis. Expressed in the proximal tubule of the cortex of 8-day-old mouse kidney (PubMed:16107722). Expressed in retina specifically at retinal Mueller glial cells (PubMed:27107718). Expressed in brain. Expressed abundantly at the choroid plexus but also expressed weakly in the parenchyma. Expressed at the capillary endothelium in the cerebral white matter (PubMed:27258268). Expressed in adult testis, in the elongated spermatids (ES) and in residual bodies inside Sertoli cells (PubMed:19812234). Mainly expressed at the brain surface with a slight expression in the brain parenchyma at postnatal day 1, 7, and 14. At the stage of postnatal day 28, mainly expressed in the parenchyma. Increased by glucose (PubMed:23486012). Decreased by phlorizin (PubMed:23486012). The NPC motif is essential for oligomerization and water permeability function. Not glycosylated. Homozygous Aqp11 knockout mice are born normally at the expected Mendelian frequency and are normal. However, after 15 days mice begin dying, and only 15% survive until day 60. Mice exhibit severe renal dysfunction with a significant increase of blood urea nitrogen (BUN) level. The kidneys are large and pale with rough texture occupying the whole abdominal cavity. The kidneys are anemic and polycystic following swelling and vacuolization of the proximal tubule (PubMed:18701606, PubMed:16107722). Mice with conditional knockout of Aqp11 in liver appear to have a normal life span of more than 1 year, are fertile (both females and males), show a normal growth rate, and do not show any behavioral abnormalities. Unchallenged mice have normal longevity, their livers appear normal, and reveal only a minor defect in lipid handling. In contrast, rough endoplasmic reticulum (RER)-derived vacuoles develop rapidly in the periportal hepatocytes of liver-specific following 24 h fasting and refeeding (PubMed:23275615). Mice with temporal conditional knockout of Aqp11 between post natal days (P) P2 and P12 exhibit apparently normal kidneys at birth and within the first two postnatal weeks of life exhibit tubular dilations. When conditional knockout of Aqp11 is induced until P8, proximal tubule (PT) cell vacuolization and apparent tubular cysts are formed, whereas no deficient renal development are observed if conditional knockout of Aqp11 starts at P12 (PubMed:27582095). Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.