Together with NovI, involved in the formation of a beta-OH-Tyr intermediate in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases. The ATP-dependent AMP-binding region activates L-Tyr as L-tyrosyl-AMP and then transfers the L-tyrosyl group to the acyl carrier domain through thioester formation to form a tyrosyl-S intermediate that is covalently tethered to NovH (L-Tyr-S-NovH). kcat is 15 min(-1) with L-Tyr as substrate. kcat is 0.44 min(-1) with p-Br-DL-Phe as substrate. kcat is 0.13 min(-1) with L-Phe as substrate. kcat is 0.23 min(-1) with 3-Cl-L-Tyr as substrate. kcat is 0.0083 min(-1) with 3-Me-L-Tyr as substrate. Antibiotic biosynthesis; novobiocin biosynthesis. Belongs to the ATP-dependent AMP-binding enzyme family.