May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. Cellular negative regulator of the hepatitis B virus (HBV) X protein. Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex. Widely expressed. Higher levels seen in the heart, placenta and skeletal muscle. Not expressed in the liver. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.