Orphan nuclear receptor. May act concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. Participates in energy homeostasis by sequestrating the kinase STK11 in the nucleus, thereby attenuating cytoplasmic AMPK activation (By similarity). Plays a role in the vascular response to injury (PubMed:22427340). Binds DNA as a monomer (By similarity). Interacts with GADD45GIP1. Interacts with STK11 (By similarity). Interacts with IFI27 (By similarity). Heterodimer (via DNA-binding domain) with RXRA (via C-terminus); DNA-binding of the heterodimer is enhanced by 9-cis retinoic acid (By similarity). Competes for the RXRA interaction with EP300 and thereby attenuates EP300 mediated acetylation of RXRA (By similarity). Nuclear export to the cytoplasm is XPO1-mediated and positively regulated by IFI27. Translocation to the mitochondrion upon interaction with RXRA and upon the presence of 9-cis retinoic acid (By similarity). Highest levels occur in the testis followed by brain and muscle tissue. Highest levels are found in the adult with barely detectable levels in pre- and early postnatal tissue. By serum growth factors and during liver regeneration. Phosphorylated at Ser-354 by RPS6KA1 and RPS6KA3 in response to mitogenic or stress stimuli. Acetylated by p300/CBP, acetylation increases stability. Deacetylated by HDAC1 (By similarity). Homozygous knockout mice display restenosis, the narrowing of blood vessels upon vascular injury. Belongs to the nuclear hormone receptor family. NR4 subfamily.