Substrate-recognition component of a Cul7-RING ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Cul7-RING(FBXW8) complex also mediates ubiquitination of MAP4K1/HPK1: recognizes and binds autophosphorylated MAP4K1/HPK1, leading to its degradation, thereby affecting cell proliferation and differentiation. Associated component of the 3M complex, suggesting that it mediates some of 3M complex functions (By similarity). The Cul7-RING(FBXW8) complex mediates ubiquitination and consequent degradation of GORASP1, acting as a component of the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Protein modification; protein ubiquitination. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1, FBXW8 and GLMN isoform 1. Interacts with CUL7. Interacts with OBSL1, CUL1, CUL2, SKP1, CCT6B, PFDN5, CCT2, CCT3, CCT6A, CCT7, VBP1, CCDC8, ARF1, TRIP13, and PDCD5. Interacts with MAP4K1/HPK1 (when autophosphorylated). Associated component of the 3M complex (By similarity). Interacts with GORASP1. Interacts with POUF51 (when phosphorylated on 'Ser-347') (By similarity). Colocalizes with CUL7 at the Golgi apparatus in neurons. Expressed in placenta and embryonic brain (at protein level). In cerebellum, abundantly expressed during the first two postnatal weeks, with levels decreasing thereafter. In primary granule neurons, highly expressed at postnatal day 6 (P6), with levels decreasing with neuron maturation (at protein level).