Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Protein modification; protein ubiquitination. Neddylated; which enhances the ubiquitination activity of SCF-like complex. Belongs to the cullin family.