Stimulates the host immune inflammatory signaling system allowing the host to combat the bacteria. Stimulates mouse interleukin-6 (Il6) production (PubMed:23584588). During infection of mouse bone marrow-derived macrophages (BMDM) expression decreases when the bacteria is expected to be in the phagosome. Disruption of genes for cas9 or either of its associated tracrRNA or scaRNA increases transcript levels about 100-fold both in culture and in mouse BMDM. Significantly decreases interleukin-6 (Il6) production in a Tlr2-dependent fashion by C57BL/6 mouse BMDM.