Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:10978325). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). 2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in) Interacts with NEDD4 and NEDD4L. Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.