One of an enzyme pair that work together to convert the A antigen to the H antigen of the O blood type, which together release galactosamine. Catalyzes the second step in the conversion, acts on the product of the first reaction (FpGalNAcDeAc, AC P0DTR4). Is specific for galactosamine containing sugars, does not cleave GalNAc residues. an alpha-D-galactosaminyl-(1->3)-[alpha-L-fucosyl-(1->2)]-beta-D-galactosyl derivative + H2O = an alpha-L-fucosyl-(1->2)-beta-D-galactosyl derivative + D-galactosamine Optimum pH is 6.5. Has an N-terminal glycoside hydrolase 36 domain with a probable carbohydrate-binding domain in the C-terminus. The C-terminus is not required for activity on soluble substrates but increases efficiency of cleavage in red blood cells. 5 ug/ml of this enzyme pair converts A blood type to O blood type in an hour, and can be removed by centrifugation, showing the pair can be used for production of universal type donor blood. DNA was isolated from a male human fecal sample of AB+ blood type, the sequence was given to UniProtKB by the submitters. Belongs to the glycosyl hydrolase 36 family. Dropping barriers - Issue 220 of December 2019