Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 9-, 11- and 13-hydroperoxy fatty acids. Oxidizes linoleic acid to mainly 9S- and 13R-HPODE and alpha-linolenic acid to 11R-HPOTrE. (9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate (9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate (9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate (9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate Three His residues, the carboxyl oxygen of the C-terminal Ile or Val residue, and a fifth residue, usually Asn, ligate the metal, which binds water to form a catalytic base Mn(2+)OH(2) for hydrogen abstraction. N- and O-glycosylated. Belongs to the lipoxygenase family. Manganese lipoxygenase subfamily.