AMP deaminase plays a critical role in energy metabolism. Catalyzes the deamination of AMP to IMP and plays an important role in the purine nucleotide cycle. AMP + H(+) + H2O = IMP + NH4(+) Binds 1 zinc ion per subunit. Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1. Homotetramer. Highly expressed in cerebellum. Methylated at Gln-6 by N6AMT1. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.