GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. Interacts with SYNM. Interacts with PSEN1 (via N-terminus). Associated with intermediate filaments. Isoforms differ in the C-terminal region which is encoded by alternative exons. Expressed in cells lacking fibronectin. Phosphorylated by PKN1. The disease is caused by variants affecting the gene represented in this entry. Belongs to the intermediate filament family. GFAP entry