L-ornithine N(5)-monooxygenase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence via intracellular iron acquisition during macrophage infection (PubMed:18404210, PubMed:21341981). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:18404210). L-ornithine + NADPH + O2 = H2O + N(5)-hydroxy-L-ornithine + NADP(+) L-ornithine + NADH + O2 = H2O + N(5)-hydroxy-L-ornithine + NAD(+) Binds 1 FAD per subunit. Siderophore biosynthesis. Homotetramer. Expression is induced during iron deprivation (PubMed:18404210). Also induced in response to reactive nitrogen species (PubMed:16030248). Expression is regulated by the transcription factor SRE1 (PubMed:22117028). Results in poor growth under low iron conditions and loss of siderophore production (PubMed:18404210, PubMed:21341981). Leads also to a significant growth defect in human and murine macrophages and attenuation in the mouse model of infection (PubMed:18404210, PubMed:21341981). Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.