ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Lipophilic anion transporter that mediates ATP-dependent transport of glucuronide conjugates such as estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Does not transport glycocholic acid, taurocholic acid, MTX, folic acid, cAMP, or cGMP. ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate Expressed in all tissues tested including liver, brain, heart, skeletal muscle, kidney and spleen. Expressed in embryo. Deficient mice exhibit increased sensitivity to paclitaxel-induced mortality associated with weight loss, decreased white blood cell, and small spleen and thymus cortex due to apoptosis and/or depopulation of lymphoid cells. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.