Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Interacts with KRT5. Additional isoforms seem to exist. Expressed in ameloblasts at the periphery of mandibular molars at P1 (PubMed:12657653). At P3 also expressed at the molar incisal region (PubMed:12657653). Expressed at the terminal of Tomes' processes of ameloblasts at the incisal region at P5 (PubMed:12657653). Several forms are produced by C-terminal processing. Phosphorylated by FAM20C in vitro. Belongs to the amelogenin family.