May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability. Interacts with alpha-tubulin (PubMed:27512957). Interacts with SIRT2 (PubMed:27512957). Also localizes to microtubules. Very high expression in heart, skeletal muscle, liver, and kidney. The levels of expression are uniform throughout the brain. Ubiquitinated and degraded by the proteasome. Belongs to the BEX family.