Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:11368519). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (By similarity). 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) 3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) 3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) 3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) Expressed highly in the colon, kidney and small intestine of male and female dogs. Highly expressed in the jejunum and ileum of the male dog than the female dog, which displayed more expression in duodenum (at protein level). Contrary to other mammalian orthologs the canine SULT1B1 does not shown sulfotransferase activity toward dopamine. Belongs to the sulfotransferase 1 family.