Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Involved in biofilm formation. Found anchored in the cell membrane as well as a covalently-linked GPI-modified cell wall protein (GPI-CWP). Induced by RIM101 at pH8, hypoxia, ketoconazole, ciclopirox, and during hyphal growth. Regulated by UPC2 and BCR1. The CFEM domain is involved in heme-binding and contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens (PubMed:12633989). The CFEM domain adopts a novel helical-basket fold that consists of six alpha-helices, and is uniquely stabilized by four disulfide bonds formed by its 8 signature cysteines (By similarity). The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Mannosylated. Belongs to the RBT5 family.