Algogenic for animals, human and insects (PubMed:7826413). At high concentrations (0.5-1 uM), it acts as a pore-forming protein that forms nonselective cation channels both in cell and artificial membranes (PubMed:7826413). It is weakly selective for cation over anions channel conductance is identical in both directions. At lower concentrations (1-10 nM), this heterodimer inhibits cardiac L-type calcium currents in isolated rat cardiac ventricular myocytes (PubMed:10336635). Heterodimer of an A and a B chain; disulfide-linked. Expressed by the venom gland. LD(50) is 6.8 ug/kg by intracerebroventricular injection into mice. Belongs to the ectatomin family. Ectatomin-Et subfamily.