Acts via the piwi-interacting RNA (piRNA) pathway which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and piwi proteins and governs the methylation and subsequent repression of transposons (PubMed:26472911, PubMed:26494711). Required for transcriptional silencing of transposons targeted by piwi and confers its effects by interacting with nascent RNA transcripts (PubMed:26472911, PubMed:26494711). Likely to be recruited to nascent transcripts cotranscriptionally by piwi and to recruit additional factors involved in transcriptional silencing (PubMed:26472911). In the ovaries, forms a complex with nxf2, piwi and Nxt1 which acts as effectors of cotranscriptional transposon silencing (PubMed:31219034, PubMed:31368590, PubMed:31570835, PubMed:31384064). The interaction with nxf2 stabilizes the nuclear protein complex (PubMed:31384064). In the ovaries, part of a complex composed of at least Panx, nxf2, piwi and Nxt1 (PubMed:26472911, PubMed:26494711, PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). The complex is knowns as Panx-induced cotranscriptional silencing (PICTS) complex, Panx-nxf2-dependent TAP/p15 silencing (Pandas complex), SFiNX (silencing factor interacting nuclear export variant) or piwi-Panx-nxf2-p15 (PPNP) complex (PubMed:26472911, PubMed:26494711, PubMed:31570835, PubMed:31219034, PubMed:31368590, PubMed:31384064). Interacts (via NIR region) with nxf2 (via TAP-C domain); the interaction is direct (PubMed:31368590, PubMed:31219034, PubMed:31570835, PubMed:31384064). Nuclear localization depends on interaction with nxf2. Expressed in female gonads (at protein level). N-terminal region is necessary and sufficient to enforce silencing of an artificial reporter gene. Mutants are viable but show oogenesis defects (PubMed:26494711). They also display up-regulation of transposable elements with loss of transposon H3K9 methylation and sterility in female flies (PubMed:26472911, PubMed:26494711). No effect on the abundance or content of piRNA populations or on the nuclear localization of piwi (PubMed:26472911, PubMed:26494711). RNAi-mediated knockdown in the germline increases transposon expression and impairs nuclear localization of nxf2 in nurse cells by reducing its stability (PubMed:31570835, PubMed:31219034). The name 'panoramix' derives from the mentor who empowers the French comic book character Asterix to perform his feats of strength.