Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use ADP-glucose, ADP-mannose and ADP-ribose as substrates. Regulates the intracellular ADP-glucose levels linked to starch biosynthesis. ADP-sugar + H2O = AMP + alpha-D-aldose 1-phosphate. Homodimer. Expressed in roots, leaves, stems and inflorescences. No visible phenotype under normal growth conditions. Belongs to the Nudix hydrolase family.