High affinity receptor for the Fc region of immunoglobulins gamma. Functions in both innate and adaptive immune responses. Mediates IgG effector functions on monocytes triggering antibody-dependent cellular cytotoxicity (ADCC) of virus-infected cells. Interacts with IGHG1 (PubMed:11711607). Interacts with FCERG1; forms a functional signaling complex. Interacts with FLNA; prevents FCGR1A degradation. Interacts with EPB41L2, LAT and PPL. Interacts with HCK and LYN. Stabilized at the cell membrane through interaction with FCER1G. Monocyte/macrophage specific. Phosphorylated on serine residues. Belongs to the immunoglobulin superfamily. FCGR1 family. FCGR1A mutation db