Displays weak conversion of all-trans-retinal to all-trans-retinol in the presence of NADH. Has apparently no steroid dehydrogenase activity. Granular distribution in the whole cell. Expressed in the skin (PubMed:28173123). Expressed in granular and cornified layers of the epidermis (at protein level) (PubMed:28173123). Highly expressed in liver (PubMed:12234675). The disease is caused by variants affecting the gene represented in this entry. Belongs to the short-chain dehydrogenases/reductases (SDR) family.