Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. Since the experiments have been done on F11 cells (immortalized cell line derived from rat DRG neurons mainly expressing Nav1.3/SCN3A, but also Nav1.7/SCN9A and Nav1.2/SCN2A), it is supposed to act on these channels. The slow of inactivation process is partially reversible. Is lethal to mice. Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). 10 ug of this toxin kills a mouse of 20g body weight within 20 minutes after intraperitoneal injection. Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.