holo-[ACP] + malonyl-CoA = CoA + malonyl-[ACP] Lipid metabolism; fatty acid biosynthesis. Pupylated at Lys-173 by the prokaryotic ubiquitin-like protein Pup, which leads to its degradation by the proteasome. Was identified as a natural substrate of the M.tuberculosis proteasome. Was identified as a high-confidence drug target. Belongs to the FabD family.