Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Interacts (via N-terminal extracellular domain) with PTHLH and PTH (PubMed:8397094, PubMed:10913300, PubMed:18375760, PubMed:19674967). Homodimer in the absence of bound ligand. Peptide hormone binding leads to dissociation of the homodimer (PubMed:19674967, PubMed:20172855). Expressed in most tissues. Most abundant in kidney, bone and liver. N-glycosylated. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the G-protein coupled receptor 2 family. Was shown to interact with G protein subunit GNB1 and GNG2, the interaction was reduced by mutation of Trp-474 and Trp-477. However this paper was retracted due to a lack of clear and continous electron density in the complex structure. PubMed:11850620 suggests PTH1R involvement in multiple enchondromatosis. However, PubMed:15523647 shows evidence that this disease is not caused by PTH1R.