Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate. 2-deoxy-D-ribose 5-phosphate = acetaldehyde + D-glyceraldehyde 3-phosphate Inhibited by tetrahydrofurane, acetonitrile and isopropanol. kcat is 18 sec(-1) with 2-deoxy-D-ribose 5-phosphate as substrate. kcat is 1.23 sec(-1) with 2-deoxy-D-ribose as substrate. Optimum pH is 7.0. Optimum temperature is 65 degrees Celsius. However, half-life of the protein at those temperatures is low (approximately 2 minutes). Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2. Homodimer. Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.