May play a role in actin reorganization. Links clathrin-mediated endocytosis to the actin cytoskeleton. May act as Rab effector protein and play a role in vesicle trafficking (PubMed:14676205, PubMed:27552051). Required for perinuclear sorting and insulin-regulated recycling of SLC2A4/GLUT4 in adipocytes (By similarity). Interacts with EHD1 (By similarity). Interacts with EHD2. Interacts with RAB8A, RAB10, RAB13 and RAB15 (in their GTP-bound forms); at least in case of RAB8A may bind 2 molecules of RAB8A simultaneously through a high and a low affinity binding site, respectively. Mostly found in cytosol and plasma membrane. The CAAX motif is a signal for prenylation and required for endosomal colocalization with Rab8 and Rab10. The bivalent Mical/EHBP Rab binding (bMERB) domain, mediates binding to Rab8, Rab10, Rab10, Rab13 and Rab15 (in their GTP-bound forms). Prenylated (Probable). Farnelysation (predominant) and geranylgeranylation has been observed in vitro. Disease susceptibility is associated with variants affecting the gene represented in this entry. Contaminating sequence. Potential poly-A sequence.