Required for the maintenance of centromeric cohesion during interkinesis, until meiosis II (PubMed:24206843, PubMed:26272661). Required for regular configuration and segregation of sister chromatids in meiosis II (PubMed:24506176). Also required for centromere cohesion during meiosis I (PubMed:26272661). Involved in spindle organization at the end of telophase I and in meiosis II (PubMed:24506176). Required to prevent precocious release of pericentromeric cohesins during meiosis, but not for cohesion establishment and monopolar orientation of kinetochores at meiosis I (PubMed:24206843). Involved also in somatic development (PubMed:24206843). Regulates mitotic cell division and ploidy stability in somatic cell types (PubMed:24506176). May be involved in the organization of microtubules dynamics (PubMed:24506176). Involved in abiotic stresses and mono- or divalent ions tolerance and may play a role in maintaining meristematic activity under saline conditions (PubMed:24134393). PANS1 and GIG1 are part of a network linking centromere cohesion and cell cycle progression through control of APC/C activity (PubMed:26272661). Regulates the number of dividing cells in root meristem and is necessary for the anaphase onset control through an APC/C-mediated pathway (PubMed:26261921). Involved in maintaining correct chromosome arm cohesion under stress conditions (PubMed:26261921). Interacts directly with the anaphase promoting complex/cyclosome (APC/C) through the CDC27B and CDC20-1 subunits. Excluded from the nucleolus. Expressed in somatic and reproductive tissues (PubMed:24206843). Expressed in inflorescence, young buds, roots and basal portion of young leaves (PubMed:26272661). Expressed in proliferating cells such as apical meristems of roots and shoots, expanding cotyledons and leaves, root vascular tissues, and in stomatal precursor cells (PubMed:26261921). Cell cycle regulated with a peak at late M/early G1 phase mitosis (PubMed:24206843). Peak of expression during metaphase (PubMed:26261921). Strongly expressed up to mid-prophase I and decreases during late prophase (PubMed:26272661). Not induced by stress (PubMed:26261921). The DEN-box is not essential for the meiotic function. Reduced fertility when homozygous (PubMed:24206843, PubMed:24506176). High level of gametophytic aneuploidy (PubMed:24506176, PubMed:26272661). Occurrence of split sister centromeres at metaphase I (PubMed:26272661). Pans1 and pans2 double mutants are lethal when homozygous (PubMed:24206843). Increased mono- or divalent ions sensitivity resulting in primary root growth inhibition and increased lateral root density (PubMed:24134393). Hypersensitivity to microtubule-depolymerizing drugs and higher frequency of anaphase bridges under stress conditions (PubMed:26261921). Patronus is Latin for protector.