This is one of the five types (D1 to D5) of receptors for dopamine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. In Xenopus D2R is involved in the regulation of the melanotrope cells of the intermediate pituitary during background adaptation of the animal. Brain; pituitary. Palmitoylated. Palmitoylation is probably required for proper localization to the plasma membrane and stability of the receptor. Belongs to the G-protein coupled receptor 1 family.