Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides. Most active with substrates possessing a chloroacetamide structure. Trans-cinnamic acid and 1-chloro-2,4-dinitrobenzene are not effective substrates. May play an important role in the benoxacor-mediated protection of maize from metolachlor injury. glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Optimum pH is 7.5-8. Active from pH 6 to 9. Homodimer or heterodimer of GST-I and GST-IV (=GST-II). Seedling roots. By herbicides. Belongs to the GST superfamily. Phi family.