Involved in transport of phospholipids. Contributes to transmembrane flipping of lipids. Has activity with phosphatidylserine and with a much lower efficiency with phosphatidylethanolamine, but not with phosphatidylcholine. ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2. Requires the presence of an ALIS protein to exit the endoplasmic reticulum to the cell membrane. Expressed in roots, flowers, anthers, leaves, vascular tissues and stems. Knockdown mutants are cold sensitive. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.