Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Active on cephalosporin and penicillin. a beta-lactam + H2O = a substituted beta-amino acid Binds 2 Zn(2+) ions per subunit. The enzyme can also function with only 1 Zn(2+) ion (PubMed:9761898). Inhibited by captopril stereoisomers and iodoacetate (PubMed:3930467, PubMed:26482303). Also inhibited by chelating agents such as EDTA (PubMed:3930467). Monomer. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.