UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile (PubMed:18719240). Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds (PubMed:18719240). Catalyzes the glucuronidation of the endogenous estrogen hormone estradiol (PubMed:18719240). glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP By phenobarbital. Belongs to the UDP-glycosyltransferase family.