Implicated in endocytosis. May recruit other proteins to membranes with high curvature (By similarity). Interacts with ARC (By similarity). Interacts with SYNJ1 and DNM1. Interacts with PDCD6IP. Interacts with BIN2. Associated with postsynaptic endosomes in hippocampal neurons. Ubiquitous. Higher expression in pancreas, placenta, prostate, testis and uterus. An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. In some cases of acute leukemia, a translocation results in the formation of a KMT2A/MLL1-EEN fusion gene. Belongs to the endophilin family.