Epoxide hydrolase capable of hydrolyzing long or bulky lipophilic epoxides such as 9,10-epoxystearic acid and cholesterol 5,6-oxide in vitro. The physiological substrates have yet to be identified, but could be fatty acid or steroid derivatives. an epoxide + H2O = an ethanediol 5,6alpha-epoxy-5alpha-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol 5,6beta-epoxy-5beta-cholestan-3beta-ol + H2O = 5alpha-cholestane-3beta,5,6beta-triol Is inhibited by the anti-epileptic drug valpromide (Ki value of about 100 uM). Homodimer. Is also present as monomer in solution. Belongs to the limonene-1,2-epoxide hydrolase family.