Transcriptional regulator that regulates both the azasperpyranone A biosynthesis clusters A and B (PubMed:31908094). Specifically up-regulates the expression of the cluster A and B specific transcription factors ATEG_03638 and ATEG_07666, which in turn activate the expression of their respective clusters (PubMed:31908094). Results in the significant down-regulation of both azasperpyranone A biosynthesis clusters A and B, including the cluster-specific transcription factors ATEG_03638 and ATEG_07666. Azasperpyranones display potential anti-cancer activities (PubMed:31908094). Azasperpyranones A, C, D, and F exhibit potent growth-inhibitory activity against the A549, HepG2, HCT-116, and HL-60 cell lines, with IC(50) values of 2.39-14.42 mm, respectively (PubMed:31908094). Moreover, azasperpyranone D significantly inhibits HCT-116 xenograft tumor growth in BALB/c-nu mice (PubMed:31908094). In addition, azasperpyranones A and C can bind with four kinds of therapeutic targets for cancer, eEF2K, FGFR, survivin, and TNF-a (PubMed:31908094).