Component of the dammarane-type triterpene saponins (e.g. PPT-type ginsenosides or panaxosides) biosynthetic pathway (PubMed:27746309, PubMed:29378087). Catalyzes the formation of protopanaxatriol from protopanaxadiol during ginsenoside biosynthesis, a class of tetracyclic triterpenoid saponins. (20S)-protopanaxadiol + O2 + reduced [NADPH--hemoprotein reductase] = (20S)-protopanaxatriol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Activated by N,N'-dicyclohexylcarbodiimide (DCCD) thus leading to increased ginsenosides accumulation. Secondary metabolite biosynthesis; terpenoid biosynthesis. Accumulates ubiquitously in all organs of plants, including roots, stems and leaves. Accumulates strongly from the leaf opened to the green fruit stage (PubMed:30577538). High levels are maintained until the red fruit stage, but decrease drastically during the root growth stage (PubMed:30577538). Expression is not affected by methyl jasmonate (MeJA) treatment (PubMed:22875608). Induced by A.niger mycelium-derived elicitor, thus improving ginsenosides production in adventitious roots culture (PubMed:27746309). Slightly induced by Tween 80 (PubMed:24889095). Influenced in roots by relative humidity and photosynthetically active radiation (PAR), and in leaves by temperature and rain (PubMed:30577538). Belongs to the cytochrome P450 family.