Acts as a positive regulator of apoptosis. May also act as a regulator of cellular reactive oxygen species. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Inhibited by thiazolidinedione-type compounds: inhibited by furan- and pyridone- thiazolidinediones. Highly expressed in bone marrow. Lower levels in brain, heart, lung, liver and kidney. Autophosphorylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily.