Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of dopamine, small phenols such as 1-naphthol and p-nitrophenol and thyroid hormones, including 3,3'-diiodothyronine, triidothyronine (T3) and reverse triiodothyronine (rT3) (PubMed:28084139, PubMed:9443824, PubMed:9463486). May play a role in gut microbiota-host metabolic interaction. O-sulfonates 4-ethylphenol (4-EP), a dietary tyrosine-derived metabolite produced by gut bacteria. The product 4-EPS crosses the blood-brain barrier and may negatively regulate oligodendrocyte maturation and myelination, affecting the functional connectivity of different brain regions associated with the limbic system (PubMed:35165440). 3'-phosphoadenylyl sulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate + H(+) 3'-phosphoadenylyl sulfate + 3,3',5-triiodo-L-thyronine = 3,3',5-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) 3'-phosphoadenylyl sulfate + 3,3',5'-triiodo-L-thyronine = 3,3',5'-triiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) 3'-phosphoadenylyl sulfate + 3,3'-diiodo-L-thyronine = 3,3'-diiodo-L-thyronine sulfate + adenosine 3',5'-bisphosphate + H(+) 3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 3-O-sulfate + H(+) 3'-phosphoadenylyl sulfate + dopamine = adenosine 3',5'-bisphosphate + dopamine 4-O-sulfate + H(+) 3'-phosphoadenylyl sulfate + 4-ethylphenol = 4-ethylphenyl sulfate + adenosine 3',5'-bisphosphate + H(+) Highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) and spleen. A lesser expression was observed in the lung, placenta and thymus. Belongs to the sulfotransferase 1 family.