Acts as a regulator of Wnt signaling pathway by regulating beta-catenin (ctnnb1) nuclear localization (PubMed:25183871). Required for appendage regeneration by regulating cell proliferation (PubMed:19014929). Interacts with ctnnb1. Mainly expressed in proliferating tissues (PubMed:19014929). Following amputation, expressed in regenerating tissues (PubMed:19014929). Loss of posterior structures and beta-catenin (ctnnb1)-dependent gene transcription due to the absence of accumulation of beta-catenin (ctnnb1) in the nucleus (PubMed:25183871). Fishes show reduced regenerative outgrowth following amputation due to decreased cell proliferation (PubMed:19014929). Belongs to the FAM53 family.