Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal. Interacts with TLR3, TLR5, TLR7, TLR8, TLR9 and TLR13 (probably via transmembrane domain). Colocalizes with LAMP5 in large endosomal intracellular vesicles (By similarity). Relocalizes from endoplasmic reticulum to endosome and lysosome upon cell-stimulation with CpG dinucleotides. Upon interleukin-4 treatment in B-cells. N-glycosylated. Belongs to the unc-93 family. Truncated N-terminus.