Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3') (PubMed:2011512, PubMed:1281152). Regulates IL6 expression in B cells with POU2AF1 (PubMed:23045607). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Activates octamer-containing promoters. Activates octamer-containing promoters. Activates octamer-containing promoters. Represses some promoters and activate others. Represses some promoters and activate others (PubMed:1281152, PubMed:2011512). Activates the U2 small nuclear RNA (snRNA) promoter (By similarity). Unable to bind to the octamer motif, but can still activate the beta-casein gene promoter at low levels. Transactivation activity is enhanced by transcriptional coactivator POU2AF1. Interacts with NR3C1, AR and PGR. Interacts with POU2AF1; the interaction increases POU2F2 transactivation activity. In alveolus epithelial cells of mammary glands, present in the nucleus and cytoplasm. In HC11 mammary epithelial cells, present in the nucleus and preinuclear regions. Additional isoforms seem to exist. Highest in B cells, but also present in brain (neuronal and glial cells), intestine, kidney, and testes. Expressed at higher levels in B-cells than in neuronal cells. Expressed in neuronal cell lines and brain, but not dorsal root ganglia. Expressed at lower levels in neuronal cells than in B cells. Expressed in neuronal cell lines, and at lower levels in neuroblastoma and dorsal root ganglia. Widely expressed in the developing nervous system but expression is confined to very specific regions in the adult brain, it is expressed at a lower level in B cells. Either absent in, or expressed at very low levels in neuronal cells and brain. Expressed in all tissues tested: mammary gland, liver, spleen, lung, kidney intestine, uterus and ovary of a virgin mouse. Levels of isoform OCT2.7 are highest in spleen and lung. In mammary gland, expression is localized to the alveolus epithelial cells. Widely but not homogeneously expressed in developing nervous system. Expression levels in mammary glands are barely detectable in virgin mice, levels increase during pregnancy, reaching a maximum during late pregnancy, then decrease during lactation becoming very low post-lactation. In B cells, expression is highly increased upon activation by LPS or CpG. Mutants show normal development of germinal center B cells when infected by influenza virus. The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms. The isoform OCT2b described in PubMed:7888080 corresponds to the isoform OCT2a of PubMed:1976089. To avoid any confusion, we use the nomenclature from PubMed:2011512 to describe the different isoforms. Belongs to the POU transcription factor family. Class-2 subfamily. Truncated N-terminus.