Promotes cell survival by suppressing apoptosis induced by BAX but not BAK (By similarity). Increases binding of AHCYL1/IRBIT to ITPR1 (By similarity). Reduces ITPR1-mediated calcium release from the endoplasmic reticulum cooperatively with AHCYL1/IRBIT under normal cellular conditions (By similarity). Under apoptotic stress conditions, dissociates from ITPR1 and is displaced from mitochondria-associated endoplasmic reticulum membranes, leading to increased Ca(2+) transfer to mitochondria which promotes apoptosis (By similarity). Required for the correct formation of the microtubule organizing center during oocyte cell division, potentially via regulation of protein abundance and localization of other microtubule organizing center components such as AURKA and TPX2 (PubMed:27753540). Interacts with BAX (By similarity). Interacts with BCL2 and BCL2L1/BCLX (By similarity). Interacts with APAF1 (PubMed:9878060, PubMed:9829980). Interacts with ITPR1, ITPR2 and ITPR3; the interaction with ITPR1 is increased in the presence of AHCLY1 (By similarity). Interacts with AHCYL1 (By similarity). Interacts with HIP1R (via ENTH and I/LWEQ domains) (By similarity). Interacts with CASP9 (By similarity). Interacts with BCL2L11/BIM (By similarity). Interacts with BIK (By similarity). Interacts with UBQLN4 (By similarity). Interacts with NME2/NM23-H2 (PubMed:17532299). Interacts with PMAIP1/NOXA (By similarity). Interacts with TPX2 (PubMed:27753540). Interacts with UBQLN1; in the cytoplasm (By similarity). Interacts (via BH1 domain) with BECN1 (By similarity). Localizes to mitochondria-associated endoplasmic reticulum membranes (MAMs) (By similarity). Localization to MAMs is greatly reduced under apoptotic stress conditions (By similarity). Expressed in multiple embryonic tissues (PubMed:9829980). Restricted to the ovary and testis in adult mice (PubMed:9878060, PubMed:9829980). Expressed during all phases of oocyte maturation; localized at the meiotic spindle and spindle poles during meiosis. Monoubiquitinated by UBQLN1; results in stabilization of BCL2L10 protein abundance and in relocalization from mitochondria to cytoplasm. Belongs to the Bcl-2 family.