Cooperates with AGTR2 to inhibit ERK2 activation and cell proliferation. May be required for AGTR2 cell surface expression. Together with PTPN6, induces UBE2V2 expression upon angiotensin-II stimulation (By similarity). Homodimer. Interacts with AGTR2. Interacts with PTPN6 (By similarity). In neurons, translocates into the nucleus after treatment with angiotensin-II. Belongs to the MTUS1 family.