Involved in the biosynthesis of the macrolide antibiotics methymycin, neomethymycin, narbomycin, and pikromycin. DesVIII assists the folding of the DesVII polypeptide. However, unlike chaperones, it remains bound to DesVII during catalysis, forming a tight DesVII/DesVIII complex. Although the formation of the DesVII/DesVIII complex is essential for the catalytic activity, DesVIII is unlikely to be involved in catalysis directly. Antibiotic biosynthesis. Forms a complex with DesVII. Cells lacking this gene are not able to produce glycosylated macrolides. EryCII, OleP1 and DnrQ are able to replace DesVIII, however the total amount of glycosylated compounds is significantly reduced. Belongs to the cytochrome P450 family. Although DesVIII shows significant similarity to cytochrome P450 family, it lacks the heme-binding sites. The conservation of amino acid sequence is confined primarily to the C-terminal half of the protein.