Plays a role in controlling neuronal activity and seizure susceptibility. acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+) Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. Homodimer. Citrate synthase is found in nearly all cells capable of oxidative metabolism. Mutation of kdn causes a behavioral mutation ('bang sensitivity' = temporarily paralysis in response to a physical jolt). Flies lacking kdn exhibit alterations in neuronal firing patterns in the giant fiber (GF) pathway. Belongs to the citrate synthase family.