Component of the outer dynein arm-docking complex (ODA-DC) that mediates outer dynein arms (ODA) binding onto the doublet microtubule. Plays an essential role for the assembly of ODA-DC and for the docking of ODA in ciliary axoneme. Component of the outer dynein arm-docking complex along with ODAD1, ODAD2, and ODAD3 (By similarity). Interacts with ODAD1; this interaction may facilitate the recruitment and/or attachment of outer dynein arm docking complex proteins, including ODAD1, ODAD3 and ODAD2, to ciliary axonemes (By similarity). Interacts with components of the IFT complex A, including IFT140, TTC21B/IFT139 and WDR19/IFT144, and the IFT complex B, including IFT46, IFT52 and IFT57 (PubMed:25860617). At 7.5 dpc, strong expression restricted to the ventral node, the left-right organizer (PubMed:27486780). Up-regulated in tracheal epithelial cells during in vitro differentiation into multiciliated cells (PubMed:25860617). Heterozygous intercrosses reveal deviation from the Mendelian distribution, with only 6 homozygous out of 53 born mice, suggesting increased death in utero. Most surviving homozygous mice present with small body size, some with hydrocephalus at the age of 2 weeks. They display a variety of left-right body asymmetry defects, including reversal of lung lobation or dextrocardia. At the cell level, the trachea and fallopian tubes of mutant animals show absence of outer dynein arms from the ciliary axonemes, and consequently severe reduction of cilia beating. There is no evidence of short cilia or a reduction in cilia number.