Peroxisomal catalase involved in the oxidative stress response serving to protect cells from toxicity (PubMed:25243607, PubMed:28456303). Plays a role in maintaining normal lifespan (PubMed:14996832). Plays a role in regulating the response to pathogens such as E.faecalis (PubMed:17483415). 2 H2O2 = 2 H2O + O2 Optimum pH is 6. Homotetramer. Up-regulated in response to Cu(2+) (PubMed:25243607). Up-regulated in response to phoxim (an organophosphorus insecticide) and carbaryl (a carbamate insecticide) (PubMed:28456303). Shortened lifespan and reduced egg laying capacity (PubMed:14996832). Abolishes ctl-2 enzymatic activity and reduces the global levels of catalase activity to 20% of the total catalase activity observed in wild-type animals (PubMed:14996832). Increased size and clustering of peroxisomes (PubMed:14996832). Increased sensitivity to pathogens (PubMed:17483415). Reduced survival and resistance to E.faecalis in a daf-2 RNAi mutant background (PubMed:17483415). Belongs to the catalase family. Was originally reported to play a role in determining adult lifespan. However, the paper was later retracted due to errors in the data.