Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). Component of the ESCRT-0 complex composed of STAM2 and HGS. Ubiquitously expressed. Phosphorylated in response to EGF and PDGF. Phosphorylated by SRC. Belongs to the STAM family.