Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Binds DNA as a homodimer. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from coactivator proteins (By similarity). Interacts (via ligand-binding domain) with TRIM68 (By similarity). Detected in somatic Leydig and Sertoli cells in testis with high level expression. Also detected at lower expression levels in forebrain and heart. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. In the presence of bound steroid the ligand-binding domain interacts with the N-terminal modulating domain, and thereby activates AR transcription factor activity. Agonist binding is required for dimerization and binding to target DNA (By similarity). Belongs to the nuclear hormone receptor family. NR3 subfamily.