Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b (PubMed:9498573). In vivo, when tested on rat arthritis models, shows anti-inflammation and immunosuppression effects (PubMed:27840083). Expressed by the venom gland. LD(50) is 0.09 mg/kg by subcutaneous injection. Analgesic available under the trade name Cobratide (approved by the National Medical Products Administration of China). Has been safely used since 1978. Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily.