Developmentally regulated neuraminidase implicated in parasite invasion of cells. May contribute to the pathology during T.cruzi infection by cleaving sialic acid from cells of the immune system. Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. Mammalian stage of parasite. The parasite mammalian stage surface antigen exhibits extensive antigenic diversity. Belongs to the glycosyl hydrolase 33 family.