Possible role in modulating immune responses. Induces morphological changes including production of filopodia and microspikes when overexpressed in a variety of cell types and may be involved in dendritic cell maturation. Isoform 1 and isoform 2 have an inhibitory effect on lymphocyte proliferation. Also detected in a perinuclear region corresponding to the localization of the Golgi apparatus and throughout the cytoplasm. Additional isoforms seem to exist. Expressed in lung, tonsil, thymus, placenta, kidney, fetal spleen, fetal liver and brain. By IFNG/IFN-gamma. Up-regulated upon autoimmune and bacterially-induced inflammation. Belongs to the LST1 family. Truncated C-terminus.