Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1/GLUT1, SLC16A3, SLC16A8, SLC16A11 and SLC16A12 to the plasma membrane (By similarity). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Homooligomer (By similarity). Interacts with VEGFA, KDR/VEGFR2, PPIA/CYPA, SLC16A1/GLUT1, SLC16A12, SLC16A11, ATP1B2, MAG, L1CAM and AJAP1 (By similarity). Interacts with SLC16A3; interaction mediates SLC16A3 targeting to the plasma membrane (By similarity). Interacts with PPIL2; regulates BSG transport to the cell membrane (By similarity). Interacts with XKR8; promoting its localization at the cell membrane (By similarity).