Plays a role in the regulation of proliferation. Regulates TERT expression by modulating SP1 binding to TERT promoter binding sites. Shuttles between nucleus and cytoplasm. Specifically expressed in testis. Methylated at Gln-1046 by N6AMT1. Phosphorylation on Ser-1026, Ser-1029 or Ser-1031 is important for cytoplasmic export. A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with BRD4 which produces a BRD4-NUTM1 fusion protein. A chromosomal aberration involving NUTM1 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with BRD3 which produces a BRD3-NUTM1 fusion protein. Belongs to the NUT family. Extended N-terminus.