Restriction of 5-methyl and 5-hydroxymethylcytosines at the specific DNA sequence 5'-C(me)CGG-3'. Encoded by the SOS-inducible cryptic lambdoid prophage e14 (PubMed:1938927, Ref.2, PubMed:9278503, PubMed:16738553). UV treatment leads to prophage excision and reduced levels of McrA (PubMed:1938927, Ref.2).