Esterase that catalyzes the hydrolysis of p-nitrophenyl esters of acyl chain lengths C4-C10 and Tween detergents. Has also a pronounced thioesterase activity towards palmitoyl-coenzyme A. a carboxylic ester + H2O = a carboxylate + an alcohol + H(+) H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate The N-terminal esterase domain, when expressed alone, shows activities five to ten times higher than those of the complete enzyme EstP towards all tested substrates, whereas substrate affinity and the activity profiles are still the same. Contains a C-terminal autotransporter domain that integrates into the outer membrane and enables the translocation of the catalytic N-terminal domain to the bacterial cell surface. Belongs to the 'GDSL' lipolytic enzyme family.