Transcriptional activator essential for osteoblast differentiation (PubMed:11792318, PubMed:17510056, PubMed:30026585). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (PubMed:11792318, PubMed:17510056). Interacts with RIOX1; the interaction is direct and inhibits transcription activator activity. Osteoblast/chondrocyte specific. In response to ascorbic acid induction, expression is activated by NFE2L1 in osteoblasts. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Propionylated (PubMed:30026585). Depropionylation at Lys-368 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts (PubMed:30026585). Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours (By similarity). Death in the immediate postnatal period due to difficulty in breathing. Mice rapidly become cyanotic and die within 15 min of birth. New-born homozygous show severe inward bending of forelimbs and hindlimbs. They develop a normal cartilage skeleton but fail to form bone and to express osteoblast-specific marker genes. In endochondral skeletal elements, mesenchymal cells together with osteoclasts and blood vessels, invade the mineralized cartilage matrix. Belongs to the Sp1 C2H2-type zinc-finger protein family.