Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG). May also be activated by intracellular calcium store depletion. Interacts with MX1 and RNF24. Interacts (via ANK-repeat domains) with PRKG1. Phosphorylation by PRKG1 at Thr-15 negatively regulates TRPC7 activity. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC7 sub-subfamily.