Regulates endothelial chemotaxis and tube formation (By similarity). Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2. Interacts with FLNA. Interacts with the 20S proteasome subunit PSMA7. Expressed in all tissues examined, highest expression was observed in lung and spleen endothelial cells. May be heavily O-glycosylated. Belongs to the ECSCR family.