ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Interacts with RDX, EZR and MSN. Co-localizes with RDX, EZR and MSN in microvilli. Expressed in endothelial cells and leukocytes. High levels found in lung. Belongs to the immunoglobulin superfamily. ICAM family. ICAM-2