Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria including M.luteus, S.aureus, Streptococcus, P.micros, P.acidilactici, C.sporogenes, C.diphtheriae, A.viscosus, G.vaginalis, P.acnes, L.monocytogenes and M.smegmatis, and Gram-negative bacteria including C.jejuni, H.pylori and N.gonorrhoeae. Transiently and partially depolarizes the transmembrane electrical potential and pH gradient of susceptible cells, inhibits the uptake of amino acids and depletes the intracellular ATP pool. Stable from pH 2.0 to 4.0. Activity decreases gradually with increasing pH. Thermostable. Maturation of lantibiotics involves the enzymatic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor. It is not established whether the 2,3-didehydrobutyrine is the E- or Z-isomer (PubMed:10821848, PubMed:16626493, PubMed:9647795, PubMed:8021218 and PubMed:8660519). Belongs to the type A lantibiotic family.