Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the detoxification of certain herbicides. glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Homodimer. degradation; (R)-lactate from methylglyoxal: step 1/2. Belongs to the GST superfamily. HSP26 family. Was originally (Ref.1) thought to be a glyoxalase I.