May play an immunomodulatory role in frog skin in response to microbial pathogens, since it increases the production of the pro-inflammatory cytokines TNF-alpha, IL-1 beta, IL-12, and IL-23 by mouse peritoneal macrophages and has no effect on the production of the anti-inflammatory cytokine IL-10 (PubMed:24073891). It is not known whether stimulation of cytokine production arises from a non-specific interaction of the peptide with the macrophage membrane or from interaction with a specific receptor (Probable). Shows a low activity in stimulating insulin release from rat BRIN-BD11 beta cells, and acts without loss of integrity of the plasma membrane (PubMed:19428765). Shows a marked affinity for both neutral and anionic membranes models (PubMed:24073891). Does not show antibacterial (E.coli and S.aureus) (PubMed:19428765). Does not show hemolytic activity against human erythrocytes (PubMed:19428765). Forms a helical membrane channel in the target. Expressed by the skin glands. Amphipathic peptide that adopts a random coil conformation in water, a beta-sheet structure in methanol, and an alpha-helical conformation in trifluoroethanol-water. Plasticins have huge conformational plasticity. They can display random coil, alpha-helical, beta-sheet or beta-harpin structures. Monoisotopic mass. Belongs to the frog skin active peptide (FSAP) family. Plasticin subfamily.