Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Heterodimer with UBE2N. Binds CHFR. Detected in placenta, colon, liver and skin. Detected at very low levels in most tissues. Up-regulated in cultured fresh blood cells upon treatment with vitamin D3. Belongs to the ubiquitin-conjugating enzyme family.