Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (By similarity). Involved in the regulation of the STAT pathway (Ref.4). tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis. Component of the elongator complex. Folds into a two seven-bladed beta-propeller structure which is required for elongator complex assembly. Belongs to the WD repeat ELP2 family. The elongator complex was originally thought to play a role in transcription elongation. However, it is no longer thought to play a direct role in this process and its primary function is thought to be in tRNA modification.