Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin (By similarity). Transcriptionally activated by CEBPZ, which recognizes a CCAAT-like motif, CAAAT in the COL5A1 promoter. Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4 (By similarity). Widely expressed (PubMed:22149965). Isoform 2 is more highly expressed in liver, kidney and lung (PubMed:22149965). Detected at 11 dpc, 12 dpc, 14 dpc, 16 dpc and 18 dpc. Expressed in limbs, vertebrae, heart, brain, liver, intestine, tongue, tail, skin, calvaria, lung and kidney of 18 dpc embryos (PubMed:9582436). Isoform 2 is detected at 13.5 dpc and its expression increases from 13.5 dpc to 5 weeks after birth more specially in liver, lung, ileum and heart. The expression slightly decreases after 15 weeks (PubMed:22149965). Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. Sulfated on 40% of tyrosines. Belongs to the fibrillar collagen family.