Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate (PubMed:27322068). Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism (PubMed:27322068). beta-D-fructose 1-phosphate + H2O = D-fructose + phosphate beta-D-fructose 6-phosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone Phosphatase activity is strongly promoted by several divalent cations but is it suggested that Mn(2+) and possibly Ni(2+) represent biologically relevant metal ion cofactors for damage-control phosphatases. Activity is strongly promoted by Co(2+), Ni(2+) and Mn(2+) (PubMed:27322068). Activity is inhibited by EDTA (PubMed:27322068). kcat is 11.6 sec(-1) with fructose-1-phosphate as substrate. kcat is 4.2 sec(-1) with fructose-6-phosphate as substrate. kcat is 3.3 sec(-1) with mannose-6-phosphate as substrate. kcat is 1.9 sec(-1) with 2-desoxyribose-5-phosphate as substrate. Expression is up-regulated in response to treatment with the DNA-damaging agent methyl methanesulfonate (MMS). Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. Leads to the accumulation of fructose-1-phosphate (PubMed:27322068). Leads to increased DNA damage or decreased repair (PubMed:18085829). Present with 6190 molecules/cell in log phase SD medium. Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.