May be an angiogenesis inhibitor. Widely expressed with highest expression in tendons and ligaments, in the diaphragm, eye and skeletal muscle. Expressed in neuronal cells of all brain regions. Very low expression, if any, in glial cells. Expression already detected at 9.5 dpc and maintained throughout embryonic development. At 17.5 dpc, high levels found in tendons and ligaments of the skeletomuscular system, including the knee joint, the upper limb and the intercostal ligaments. At this developmental stage, high expression is also detected in the tendinous part of the diaphragm. By contrast, low levels are observed in resting and proliferative chondrocytes of long bones and vertebral bodies, and in the cartilaginous part of the intervertebral disks. No expression in hypertrophic chondrocytes. Outside the skeletomuscular system, expressed in neuronal cells of all brain regions and the spinal cord, liver, lung, bowels, thymus and eye. Belongs to the chondromodulin-1 family. Truncated C-terminus.