Plays a role in transcriptional repression of satellite repeats, possibly by regulating H3K36 methylation levels in centromeric regions together with KDM8. Possibly together with KDM8, is involved in proper mitotic spindle organization and chromosome segregation. Plays a role in regulating alpha-tubulin deacetylation and cytoskeletal microtubule stability, thereby promoting cell migration and TGF-beta-induced epithelial to mesenchymal transition (EMT), potentially through the inhibition of KDM8. Found in a complex with KDM8. Interacts (via N-terminus) with KDM8 (via N-terminus). Colocalizes with trimethylated 'Lys-9' of histone H3 (H3K9me3). Specifically hydroxylated (with R stereochemistry) at C-3 of ARG-141 by KDM8.