Has a critical role in neuronal development, particularly in the formation and/or maintenance of dendritic spines and synapses (PubMed:25807484). Involved in the regulation of canonical Wnt signaling (By similarity). It probably acts on beta-catenin turnover, facilitating beta-catenin interaction with GSK3B, phosphorylation, ubiquitination and degradation (PubMed:20623542). May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. Functions as a transcriptional activator when bound to ZBTB33 (By similarity). Binds to E-cadherin at a juxtamembrane site within the cytoplasmic domain (By similarity). Binds to PSEN1 (By similarity). Interacts with ZBTB33 (By similarity). Interacts with ARHGEF28 (By similarity). Interacts (via the extreme C-terminus) with FRMPD2 (via the PDZ 2 domain) (By similarity). Interacts with PDZD2 (PubMed:10896674). Interacts with CDK5 (PubMed:17009320). Interacts with CTNBB1 (By similarity). Interacts with GSK3A and GSK3B (By similarity). Interacts with DNM2 (By similarity). Interacts with CCDC85B (By similarity). Predominantly expressed in brain; accumulates in cortical neurons (at protein level). O-glycosylated. Phosphorylated by CDK5 (PubMed:17009320). Phosphorylated by GSK3B (By similarity). Belongs to the beta-catenin family.