Plays a role in cell adhesion (By similarity). May play a role in cell-collagen interactions (PubMed:9061001). Binds to type I, II, and IV collagens (PubMed:9061001). May be associated both with microfibrils and with the cell surface. Widely distributed in various tissues except for the brain. High levels in corneal epithelium (PubMed:9061001). Expressed in chondrocytes during all stages (PubMed:9061001). Highest levels during the prehypertrophic stage (PubMed:9061001). By TGF-beta (PubMed:9061001). Gamma-carboxyglutamated; gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation; these residues may be required for binding to calcium. According to a report, does not contain any vitamin K-dependent gamma-carboxyglutamate residues. The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain.