Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity). Interacts with RIOX1; the interaction is direct and inhibits transcription activator activity. Restricted to bone-derived cell. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Ubiquitination at leads to proteasomal degradation. SP7 is a short-live protein with an endogenous half-life of approximately 12 hours. Propionylated. Depropionylation at Lys-371 by SIRT7 activates transcription factor activity and positively regulates bone formation by osteoblasts. The disease is caused by variants affecting the gene represented in this entry. Generally expressed at much higher level than isoform 1. Belongs to the Sp1 C2H2-type zinc-finger protein family.