RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:31685995). Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (PubMed:31685995). Also required for immunity against some bacteria, such as mycobacteria (By similarity). Interacts with MAVS. By interferons (IFNs) (PubMed:31685995). Expression is induced upon viral infection (PubMed:31685995). Mice are viable without obvious physiological or behavioral abnormalities (PubMed:31685995). They however display impaired innate immune responses against RNA virus infection by producing less type I interferons (IFNs) (PubMed:31685995). Belongs to the ZNFX1 family.