ATP- and membrane-binding protein that controls membrane reorganization/tubulation upon ATP hydrolysis. Plays a role in membrane trafficking between the plasma membrane and endosomes. Important for the internalization of GLUT4. Required for fusion of myoblasts to skeletal muscle myotubes. Required for normal translocation of FER1L5 to the plasma membrane. Regulates the equilibrium between cell surface-associated and cell surface-dissociated caveolae by constraining caveolae at the cell membrane. The very low intrinsic ATPase activity is increased upon interaction with liposomes. Homodimer and homooligomer. Interacts with EHD1. May also interact with EHD3 and EHD4. Interacts with MYOF. Interacts with EHBP1. Interacts with FER1L5 (via second C2 domain). Interacts with CAV1 in a cholesterol-dependent manner. Interacts (via EH domain) with PACSIN2 (via NPF motifs); this interaction probably stabilizes the caveolae (By similarity). Colocalizes with GLUT4 in intracellular tubulovesicular structures that are associated with cortical F-actin (PubMed:14676205). Colocalizes with FER1L5 at plasma membrane in myoblasts and myotubes (By similarity). The EH domain interacts with Asn-Pro-Phe (NPF) motifs of target proteins. Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. EHD subfamily.