Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis. May play a role in the development and maintenance of differentiating epithelial tissues (By similarity). H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Inhibited by sodium orthovanadate and pentamidine. Homotrimer. Interacts with tubulin (By similarity). Interacts with ATF5. And mitotic spindle. Expressed in all tissues except heart and skeletal muscle, from 10.5 dpc to 18.5 dpc. Farnesylated. Farnesylation is required for membrane targeting. Unfarnesylated forms are shifted into the nucleus. Belongs to the protein-tyrosine phosphatase family.