Lipoxygenase that metabolizes linoleic and alpha-linolenic acids to 9S-, 11- and 13R-hydroperoxy fatty acids. At the end of lipoxygenation, the intermediate products 11S-HPODE and 13R-HPODE from linoleic acid are then transformed into 9S-HPODE as the final product. The intermediate product 11R-HPOTrE from alpha-linolenic acid is transformed into 9S-HPOTrE and 13R-HPOTrE as the final products. 9S-HPOTrE is further oxidized by the enzyme to 9,16-DiHOTrE as the end product. Also acts on gamma-linolenic acid producing 9-HOTrE(n-6) as the main metabolite. (9Z,12Z)-octadecadienoate + O2 = (9S)-hydroperoxy-(10E,12Z)-octadecadienoate (9Z,12Z)-octadecadienoate + O2 = (11S)-hydroperoxy-(9Z,12Z)-octadecadienoate (9Z,12Z)-octadecadienoate + O2 = (13R)-hydroperoxy-(9Z,11E)-octadecadienoate (9Z,12Z,15Z)-octadecatrienoate + O2 = (9S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoate (9Z,12Z,15Z)-octadecatrienoate + O2 = (11R)-hydroperoxy-(9Z,12Z,15Z)-octadecatrienoate (9Z,12Z,15Z)-octadecatrienoate + O2 = (13R)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate Three His residues, the carboxyl oxygen of the C-terminal Ile or Val residue, and a fifth residue, usually Asn, ligate the metal, which binds water to form a catalytic base Mn(2+)OH(2) for hydrogen abstraction. Belongs to the lipoxygenase family. Manganese lipoxygenase subfamily.