May have an important role in respiratory metabolism. Cryptosporidium have a relic mitochondrion with no function in energy metabolism so it is not known if PFOR has a function. CoA + NADP(+) + pyruvate = acetyl-CoA + CO2 + NADPH Binds 1 FAD per subunit. Binds 1 FMN per subunit. Homodimer. Both sporozoites and intracellular stages of life cycle. Arose from gene fusion of pyruvate:ferredoxin oxidoreductase and cytochrome-P450 reductase. Gene fusion has only been found in Euglena and Cryptosporidium. In the N-terminal section; belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.