Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Contributes to the formation of Salmonella-induced filaments (Sifs) in infected epithelial cells and to replication in macrophages. Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell. Membrane-associated. Localizes to the Salmonella-containing vacuole (SCV) in infected cells and to late endocytic compartments in transfected cells. Transcription is induced inside host cells and is dependent on the SsrA/SsrB and PhoP/PhoQ two-component systems. The N-terminal domain mediates secretion by SPI-2 TTSS and targeting of late endocytic compartments in host cells. Mutation leads to a prolonged survival of infected mice. Deletion blocks Sifs formation at an intermediate stage, before fusion of late endosome compartments with the SCV, and impairs bacterial replication in mouse macrophages but not in human epithelial cells. Belongs to the SopD family.