BCL2-like protein which disrupts the host immune response by inhibiting the TLR4 signaling pathway leading to NF-kappa-B activation. Acts close to the plasma membrane and targets several host TIR-domain containing adaptor proteins including MYD88, TIRAP, TRIF and TICAM2. In turn, blocks the host NF-kappa-B and TRIF-mediated IRF3 activation. Tetramer (PubMed:27973613). Interacts with host MYD88, TRF4, TICAM2 and MAL (PubMed:20802145). Belongs to the poxviridae A46R protein family.