Female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) (PubMed:17251266, PubMed:18020708). Required for the completion of meiosis in oocytes (PubMed:11252055, PubMed:10683177, PubMed:10924478, PubMed:17251266, PubMed:18020708). Activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis (PubMed:17251266, PubMed:18020708). Promotes the ubiquitination and degradation of CycA early in meiosis I and the degradation of CycB and CycB3 after egg activation (PubMed:18020708). Promotes degradation of mtrm at the oocyte-to-embryo transition (PubMed:24019759). Interacts with anaphase promoting complex/cyclosome (APC/C) subunits Cdc16 and Cdc27 (PubMed:18020708). Interacts with mtrm (PubMed:24019759). Highly expressed in ovaries. Expressed in nurse cells from stage 6 to stage 12 egg chambers. As oocyte matures, it is transferred from the nurse cells to the oocyte. Undetectable in early stage 1-8 egg chambers and present at very low levels in stages 9-10B egg chambers. Strongly increases in stage 12-13 egg chambers and remains high in mature stage 14 oocytes (PubMed:18020708). Protein levels drop dramatically by the time meiosis is completed in unfertilized eggs (at protein level) (PubMed:18020708). Transcription is activated by grauzone (grau), which binds to its promoter region. Probably ubiquitinated: degraded following egg activation by the anaphase promoting complex/cyclosome (APC/C). Belongs to the WD repeat CORT family.