Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective. May also be activated by intracellular calcium store depletion (By similarity). Mediates calcium-dependent phosphatidylserine externalization and apoptosis in neurons via its association with PLSCR1 (By similarity). Homotetramer and heterotetramer with TRPC1 and/or TRPC4 (By similarity). Interacts with SLC9A3R1/NHERF (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts (via C-terminus) with CABP1 (By similarity). Interacts with SESTD1 (via the spectrin 1 repeat) (By similarity). Interacts with TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity). Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC5 sub-subfamily.