May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). ATP + CMP = ADP + CDP ATP + dCMP = ADP + dCDP a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP a ribonucleoside 5'-diphosphate + ATP = a ribonucleoside 5'-triphosphate + ADP By lipopolysaccharides in macrophages and in primary microglia. Belongs to the thymidylate kinase family. Sequence differs due to frameshifts, sequencing errors and other discrepancies.