As a component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), it is involved in ciliogenesis and ciliary protein trafficking (PubMed:21473986). May promote CASP3 activation and TNF-stimulated apoptosis (By similarity). Component of the IFT complex A (IFT-A) complex. IFT-A complex is divided into a core subcomplex composed of IFT122:IFT140:WDR19 which is associated with TULP3 and a peripheral subcomplex composed of IFT43:WDR35:TTC21B. Interacts directy with IFT122, ITF43 and TTC21B. Interacts with IFT43. Immunofluorescence studies in IMCD3 cells show that Wdr35 accumulates at and around centrosomes and basal bodies of serum-starved cells, with fainter punctate staining along the cilia axoneme.