The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. The enzyme II complex composed of SrlA, SrlB and SrlE is involved in glucitol/sorbitol transport. It can also use D-mannitol. Regulated by an unusual system which consists of the activator GutM and the repressor GutR in addition to the cAMP-CRP complex. The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.