Guanine nucleotide exchange factor for ARF6 (By similarity). Induces cytoskeletal remodeling (By similarity). Interacts with ACTN1. Interacts (ARF6-bound form) with KCNK1; does not interact with KCNK1 in the absence of ARF6 (By similarity). Distributed uniformly on the plasma membrane, as well as throughout the cytoplasm during metaphase. Subsequently concentrated at patches in the equatorial region at the onset of cytokinesis, and becomes distributed in the equatorial region concurrent with cleavage furrow ingression. In later cytokinesis phases, fades away from the cleavage furrow and becomes uniformly distributed throughout the plasma membrane. Brain. Expressed in the hippocampal and dentate neuronal layers, cerebellar cortex, molecular layer of the hippocampus and dentate gyrus. On embryonic day 15 (E15) and E18, weakly expressed in the mantle zone throughout the neuraxis. On postnatal days 0 (P0) and P7, expression is evident in the cerebral neocortex, hippocampal pyramidal and dentate granule cell layers, olfactory granule, mitral cell layers and the striatum. A weak expression is seen in the gray matter of di-, mes- and met-encephalon and in the cerebellar Purkinje cells. On P14, expressed in the gray matter of the telencephalon such as the cerebral neocortex, olfactory bulb, hippocampus, dentate gyrus and striatum. On P21 and thereafter detected in the cerebellar granule cells. Belongs to the PSD family.