Dual endothelin-1/angiotensin-2 receptor that is functionally coupled to a calcium-mobilizing transduction system, responding equivalently to both endothelin-1/EDN1 and angiotensin-2 peptides in a highly specific manner (PubMed:17446437, PubMed:24465725). Also binds the signal peptide of VEGFA (PubMed:17446437, PubMed:24465725). May play a role in angiogenesis with a significant role in cardiovascular and neural development (By similarity). Expressed in kidney (PubMed:17446437). Expressed in endothelial cells (PubMed:24465725). N-glycosylated. The nonsense codon (UGA) at position 14 is modified to a sense codon (UGI), which is the equivalent of UGG. ADAR is responsible of FBXW7-AS1 expression and RNA-editing.