Responsible for physiological and behavioral changes in mated female flies. May contribute to the toxicity of seminal fluid and the decreased life-span of mated females. May also affect neuromuscular events after mating concerning sperm storage and egg release. Produced in the male genital tract (at protein level) (PubMed:10612039). Present in seminal fluid (PubMed:9474779). Transferred to the female genital tract within the first 3 minutes after the start of mating (ASM) and crosses the posterior vaginal wall into the female hemolymph 5 minutes ASM (at protein level) (PubMed:10612039).