Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway (PubMed:19666462, PubMed:22940806, PubMed:24638914). Cannot use (R)-pantoate as substrate and thus does not display pantothenate synthetase (PS) activity (PubMed:19666462, PubMed:22940806). Displays strict specificity for its natural substrates, 4-phosphopantoate, ATP and beta-alanine (PubMed:22940806). (R)-4-phosphopantoate + ATP + beta-alanine = (R)-4'-phosphopantothenate + AMP + diphosphate + H(+) Activity is not affected by 4'-phosphopantothenate or CoA/acetyl-CoA. Optimum pH is 6.5. Activity increases with temperature elevation from 65 degrees Celsius to 95 degrees Celsius. Cofactor biosynthesis; coenzyme A biosynthesis. Homodimer. Only viable in the presence of CoA or 4'-phosphopantothenate. Belongs to the archaeal phosphopantothenate synthetase family.