Transcription factor capable of interacting with purine rich repeats (GA repeats) (PubMed:25200183). Acts as a a master regulator of nuclear-encoded mitochondrial genes (PubMed:25200183). Heterotetramer of two alpha and two beta subunits (PubMed:25200183). Interacts with HCFC1, causing repression of transcriptional activity (By similarity). Acetylated by EP300/p300 (PubMed:25200183). Deacetylated by SIRT7, promoting heterotetramerization and activity (PubMed:25200183). May be due to competing acceptor splice sites. May be due to an intron retention.