(R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH Requires phosphatidylcholine as an allosteric activator for enzymatic activity. Homotetramer. Acetylation of Lys-132 is observed in liver mitochondria from fasted mice but not from fed mice. Belongs to the short-chain dehydrogenases/reductases (SDR) family.