Transcriptional repressor involved in organogenesis (PubMed:11688560, PubMed:11836251). Plays an essential role in ureteric bud invasion during kidney development (PubMed:11688560). May associate with NuRD histone deacetylase complex (HDAC) (PubMed:11836251). Interacts with components of HDAC complex including HDAC1, HDAC2, RBBP4, RBPP7, MTA1 and MTA2 (PubMed:11836251). Interacts with CCNQ (By similarity). Interacts with NSD2 (via PHD-type zinc fingers 1, 2 and 3) (PubMed:19483677). Expressed in the metanephric mesenchyme surrounding ureteric bud. Expressed in embryonic heart (at protein level) (PubMed:19483677). At 11.5 dpc expressed in limb buds, ventromedial parts of otic vesicles, endocardium, and weakly in the spinal cord and the brain (PubMed:11688560). At 14.5 dpc expressed in limb buds, anorectal region, developing olfactory bulb, nose and eye. At 10.5 dpc, expressed in the nephrogenic primordium (PubMed:11688560). At 11.5 dpc, expressed in mesonephric tubules and Wolffian ducts, and in the metanephric mesenchyme surrounding the ureteric bud (PubMed:11688560). At 14.5 dpc, expressed in the mesenchyme around the ureteric buds and weakly in comma-shaped bodies of metanephric tubules, but not in glomeruli, in the cortical regions of the developing kidney (PubMed:11688560). Death at P1 stage (PubMed:11688560). Newborns have either no kidneys or ureters, only one kidney or ureter, or two small kidneys (PubMed:11688560). The remnant kidneys have disorganized cortical structure, shrunken glomeruli, necrotic proximal tubules and multiple cysts (PubMed:11688560). At day 11.5, embryos have an incomplete ureteric bud outgrowth, fail to form tubules in the mesenchyme and show apoptosis of the mesenchyme (PubMed:11688560). Belongs to the sal C2H2-type zinc-finger protein family.