Involved in the biosynthesis of phenolic monoterpenes natural products thymol and carvacrol which have a broad range of biological activities acting as antimicrobial compounds, insecticides, antioxidants and pharmaceutical agents (Ref.1). Catalyzes the C2-hydroxylation of gamma-terpinene to produce carvacrol (Ref.1). Mediates also the C6-hydroxylation of (4S)-limonene and (4R)-limonene to form carveol (Ref.1). gamma-terpinene + 2 O2 + 2 reduced [NADPH--hemoprotein reductase] = carvacrol + 2 H(+) + 3 H2O + 2 oxidized [NADPH--hemoprotein reductase] (4S)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1S,5R)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] (4R)-limonene + O2 + reduced [NADPH--hemoprotein reductase] = (1R,5S)-carveol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Secondary metabolite biosynthesis; terpenoid biosynthesis. The monoterpenic phenol thymol is widely used as a fragrance and a flavoring ingredient in food and cosmetic industries (PubMed:29785774). Its derivatives have also several biological and pharmacological properties such as antimicrobial, antioxidant, anticarcinogenesis, anti-inflammatory and antispasmodic activities (PubMed:29785774, PubMed:29874939). Medical applications include the treatment of disorders affecting the respiratory, nervous, and cardiovascular systems (PubMed:29785774). It may also act as a growth enhancer and immunomodulator (PubMed:29785774). Thymol may also have antiviral activity toward COVID-19 by binding to the S1 receptor binding domain of the SARS-CoV-2 spike (S) glycoprotein (PubMed:32834111, PubMed:33855010). The monoterpenic phenol carvacrol is commonly used as a fragrance and a food flavoring ingredient and preservative (PubMed:24915411). Its derivatives exhibit also various biological and pharmacological properties including antioxidant, antibacterial, antifungal, insecticid, nematicid, anticancer, anti-inflammatory, hepatoprotective, spasmolytic, and vasorelaxant (PubMed:24915411, PubMed:29874939, PubMed:30836858, PubMed:33664752). Phytochemical inhibitor targeting the main SARS-CoV-2 viral protease (Mpro) and ACE2 in human host cells, carvacrol is a possible candidate for treating COVID-19 (PubMed:33664752, PubMed:32448034). Carvacrol may also have antiviral activity toward COVID-19 by binding to the S1 receptor binding domain of the SARS-CoV-2 spike (S) glycoprotein (PubMed:32834111, PubMed:33855010). Belongs to the cytochrome P450 family.