Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by inhibiting CGAS-DNA phase separation: directly binds double-stranded DNA (dsDNA) in a length dependent but sequence independent manner and is able to form DNA-induced phase separation in infected cells. DNA phase separation of ORF52 mediates disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity. Homooligomer; homooligomerizes and binds double-stranded DNA (dsDNA) cooperatively (By similarity). Interacts with host CGAS (By similarity). Belongs to the herpesviridae BLRF2 family.