Regulates independently canonical Wnt and Notch signaling by modulating LEF1 and Notch protein turnover. Stabilizes LEF1, a pivotal transcription factor in the Wnt signaling cascade, by blocking its ubiquitination. Involved in angiogenesis; involved in intersegmental vessel patterning during development. First detected at low levels in the blastula stage and begins to accumulate in the margin of the blastoderm. At the shield stage, when gastrulation starts, expressed uniformly in the margin. As gastrulation proceeds, expressed at high levels in the posterior paraxial mesoderm. In the 1 day old embryo, at the early pharyngula stage, expression in the developing brain is very strong and expression is restricted to ventral domains of the brain. Expressed in endothelial cells of the intersegmantal vessels, between somite boundaries and in the dorsal aorta. Belongs to the NRARP family.