Involved in craniofacial development. Acts upstream of the EDN1 pathway and is required for formation of the upper jaw equivalent, the palatoquadrate. The activity required for EDN1 pathway function differs between the first and second arches. Associates with DIAPH1 and controls GLI1 transcriptional activity. Could be involved in skin development. May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex (By similarity). Protein modification; protein ubiquitination. Interacts with DYRK1A, DYRK1B and DIAPH1. Interacts with DDB1. Interacts with ZNF703 (By similarity). Overexpression of DIAHP1 or active RHOA causes translocation from the nucleus to cytoplasm. Highly expressed in 10.5 dpc embryo limb buds, in an overlapping pattern with PTCH1 and GLI1. Belongs to the WD repeat DCAF7 family.