Plays a role in the biomineralization of teeth. Seems to regulate the formation of crystallites during the secretory stage of tooth enamel development. Thought to play a major role in the structural organization and mineralization of developing enamel. Interacts with KRT5. Additional isoforms seem to exist. Several forms are produced by C-terminal processing. Phosphorylated by FAM20C in vitro. Belongs to the amelogenin family.