Pleiotropic ABC efflux transporter that may be involved in the modulation susceptibility to a wide range of unrelated cytotoxic compounds. ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out) ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate (R)-miconazole(in) + ATP + H2O = (R)-miconazole(out) + ADP + H(+) + phosphate (S)-miconazole(in) + ATP + H2O = (S)-miconazole(out) + ADP + H(+) + phosphate Expression is induced upon exposure to itraconazole. Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.