Voltage-gated channel mediating the exchange of chloride ions against protons. Functions as antiporter and contributes to the acidification of the late endosome lumen. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters. 2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in) Detected in whole brain and in hippocampus neurons (at protein level). Detected in brain, trigeminus, dorsal root ganglion, spinal cord, eye, kidney, testis, skeletal muscle, thymus and pancreas. Isoform ClC-6c is expressed only in kidney. N-glycosylated on several asparagine residues. Reduced pain sensitivity and moderate behavioral abnormalities, but have normal fertility and are generally not very different from wild-type. Belongs to the chloride channel (TC 2.A.49) family. ClC-6/CLCN6 subfamily.