May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1 (By similarity). Interacts with GRB10 (By similarity). This transient binding is increased under IGF1 stimulation and leads to recruitment of GIGYF1/GRB10 complex to IGF1 receptor (By similarity). Interacts with DDX6 (PubMed:31439631). The GYF domain interacts with GRB10. Belongs to the GIGYF family.