Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as fluconazole (FLC), itraconazole (ITC), posaconazole (POS), and voriconazole (VRC). ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out) ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate Causes higher susceptibility to itraconazole (ITC) and rhodamine 6G (R-6G) (PubMed:29378705). Causes further increase in susceptibility toward fluconazole and itraconazole, when AFR1 and MDR1 are also deleted (PubMed:29378705). Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.