By structural similarity with conotoxin GS, may inhibit the sodium channel (Nav). No effect was observed upon intracranial injections into mice and intraperitoneal injections into goldfish (25 ug). Expressed by the venom duct. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. The cysteine framework is VI/VII (C-C-CC-C-C). Three different forms of TVIIA exist. Pro-10 and Pro-11 of conotoxin TVIIA are hydroxylated in TVIIA, whereas Pro-10 is not hydroxylated in [Pro10]TVIIA and neither Pro-10 nor Pro-11 are hydroxylated in [Pro10,11]TVIIA. TVIIA with hydroxyPro-10 and hydroxyPro-11. [Pro10]TVIIA with hydroxyPro-11. [Pro10,Pro11]TVIIA.