Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane. Within the EARP complex, required to tether the complex to recycling endosomes. Not involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). The EARP complex interacts with EIPR1 (PubMed:27191843, PubMed:27440922). Interacts with VPS51 and VPS53 in an EIPR1-independent manner (By similarity). Associates with membranes in an EIPR1-dependent manner. Expressed in the brain (at protein level). Belongs to the syndetin family.