Potently blocks Kv1.3/KCNA3, Kv1.2/KCNA2, and Shaker potassium channels (PubMed:24590385) and inhibits high conductance calcium-activated potassium channels (PubMed:10082164). Is potent against Kv1.3/KCNN3 (IC(50)=0.55 nM) and Kv1.2/KCNN2 (IC(50)=6.19 nM) (PubMed:24590385). It also stimulates the release of NO, IL-6 and TNF-alpha in J774.1 cells and presents a pro-inflammatory activity in mice (PubMed:21549737, PubMed:23085190). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). LD(50) is 826 ug/kg by intravenous injection into mice. The N-terminal C2-C5 disulfide bridge unique to this toxin does not appear to confer stability to the protein. Inhibits with a low efficiency Kv1.1/KCNA1, Kv1.5/KCNA5, Kv1.6/KCNA6, Kv4.3/KCND3, Kv7.1/KCNQ1, Kv7.2/KCNQ2, Kv7.4/KCNQ4, and ERG/KCNH2, and does not inhibit Kv1.4/KCNA4, Kv2.1/KCNB1, and Kv3.1/KCNC1. Belongs to the short scorpion toxin superfamily. Potassium channel inhibitor family. Alpha-KTx 12 subfamily.