Functions in exocytosis in pancreatic acinar cells regulating the fusion of zymogen granules with each other. May have a pore-forming activity on membranes and regulate exocytosis in other exocrine tissues. Monomer and homooligomer; most probably hexameric. Interacts with GP2. According to PubMed:10753942 interaction with syntaxins shown in PubMed:9244306 is physiologically questionable. Associated in a cholesterol-dependent manner with lipid rafts of zymogen granule membranes. Specifically expressed in pancreas and also detected in secretory granules of parotid gland (at protein level). Expressed in pancreas, spleen, small intestine, lung and neutrophilic granulocytes (at protein level). Expressed by epithelial cells in duodenum and colon. Expressed in gut after birth. Down-regulated in small intestine upon fasting. Contains intrachain disulfide bonds. Syncollin comes from the Greek word meaning to glue together. Contaminating sequence. Sequence of unknown origin in the N-terminal part.