Structural component of the gap junctions. Essential for generation and/or maintenance of postembryonic neuroblasts and normal development of optic lobe. Heterooligomer of Inx2 and ogre. Accumulates in the basolateral membrane of follicle cells in oocytes and epithelial cells in embryonic salivary gland and hindgut. In ovary, expressed in follicle cells. Expressed around the periphery of the embryo during cellular blastoderm formation. Repeating epidermal pattern emerges from stage 11, high levels of expression detected along the borders of each segment from stage 13. At stage 13, expressed in the dorsal branch of the tracheal system. During stage 15, detected in a few cells at each of the branch points of the dorsal trunk and at low levels in cardioblasts. In embryos, also expressed in the salivary gland and the hindgut (at protein level). At stage 17, expressed in the dorsal side of the CNS. Expressed in the imaginal wing disk. Expressed in larval CNS and in tissues outside of the CNS. In pupae, expressed in the CNS and in primary, secondary and tertiary pigment cells of the retina. Expressed during embryogenesis. Embryonic expression commences during cellular blastoderm formation, increases rapidly after cellularization and is maintained during the early stages of gastrulation. Expressed in larvae and pupae. Belongs to the pannexin family.