Contributes to invasiveness in malignant prostate cancer. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation. Nuclear and perinuclear Golgi region. Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues. The C1 domain does not bind the diacylglycerol (DAG). Autophosphorylated. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.