Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. A synthetic amidated version of this toxin potently and preferentially antagonizes neuronal rat alpha-3-beta-2 (IC(50)=55.7 nM) and alpha-6/alpha-3-beta-4 (IC(50)=90.69 nM) nAChRs. Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/7 pattern. Shows no or weak inhibitory activity on a range of nAChRs subtypes, including human and rat alpha-9-alpha-10, mouse alpha-1-beta-1-delta-epsilon, rat alpha-7, rat alpha-6/alpha-3-beta-2-beta-3, rat alpha-3-beta-4, rat alpha-4-beta-2, and rat alpha-9-alpha-10. Belongs to the conotoxin A superfamily.