Involved in tumorigenesis and may function as a negative regulator of the p53/TP53 (PubMed:12879013). May play an essential role for mitochondrial structure and function, and thermogenesis of brown adipocytes (By similarity). May regulate phagocytosis and inflammatory responses to lipopolysaccharide in macrophages (PubMed:31980577). Interacts with BRI3BP. Kidney, liver, skeletal muscle, heart and brain. Overexpressed in various tumors including leukemia, lymphoma, and carcinomas of the breast, kidney, ovary, stomach, colon and uterine cervix.