Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. Macedovicin inhibits a broad spectrum of lactic acid bacteria, several food spoilage species (e.g. Clostridium spp.) and oral streptococci (PubMed:23122510). The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Maturation of macedovicin involves the enzymatic dehydration of Thr-33 and Thr-35 into dehydrobutyrine residues, that can form a beta-methyllanthionine bond with Cys-38 and Cys-57, respectively (PubMed:23122510). This is followed by membrane translocation and cleavage of the modified precursor. Belongs to the type A lantibiotic family.