In the inner ear, may be a component of the hair cell's mechanotransduction machinery that functionally couples PCDH15 to the transduction channel. Regulates transducer channel conductance and is required for fast channel adaptation. Found in a complex with TMIE and PCDH15 (PubMed:25467981). Interacts with PCDH15; this interaction is required for efficient localization to hair bundles (PubMed:23217710). Interacts with TOMT (PubMed:28504928). Efficient localization to the plasma membrane requires the presence of PCDH15. Brain, inner ear hair cells and vestibular neuroepithelia of the inner ear (PubMed:16459341, PubMed:23217710, PubMed:15905332). In inner ear, expressed in stereocilia in a punctate pattern and at the tip-link region (at protein level) (PubMed:16459341, PubMed:23217710, PubMed:15905332). Strongly expressed in brain (PubMed:26964900). Weakly expressed in heart, testis and intestine (PubMed:26964900). Expressed in inner ear hair cells at 16.5 dpc. Expressed postnatally in inner and outer hair cells of the cochlear, as well as in vestibular hair cells. At the cochlear apex, levels are low at P1 and increased thereafter. After P7, hardly detectable at the protein level, while mRNA levels remains high in adult hair cells. Defects in Lhfpl5 are the cause of the hurry-scurry (hscy) phenotype which is characterized by rapid circling behavior, frequent shaking of head from side to side, deafness and vestibular dysfunction. Belongs to the LHFP family.