May be involved in the formation and stability of synapses as well as being involved in the clustering of nicotinic acetylcholine receptors. Interacts with dystrophin, utrophin and the syntrophins SNTA1, SNTB1, SNTB2, SNTG1 and SNTG2. Isoform 7 and isoform 8 do not interact with dystrophin. Binds dystrobrevin binding protein 1. Interacts with MAGEE1 (By similarity). In peripheral nerves, colocalizes with MAGEE1 in the Schwann cell membrane. Additional isoforms seem to exist. Highly expressed in brain, skeletal and cardiac muscles, and expressed at lower levels in lung, liver and pancreas. Isoform 2 is not expressed in cardiac muscle. Isoform 7 and isoform 8 are only expressed in muscle. The coiled coil domain mediates the interaction with dystrophin and utrophin. Phosphorylation of DTN-1 on tyrosine kinase substrate domain present in the C-terminus. The disease is caused by variants affecting the gene represented in this entry. Belongs to the dystrophin family. Dystrobrevin subfamily. Extended N-terminus.