High-capacity urate transporter, which may play a role in the urate reabsorption by proximal tubules. May have a residual high-affinity, low-capacity glucose and fructose transporter activity. Transports urate at rates 45- to 60-fold faster than glucose. Does not transport galactose. May mediate small uptake of adenine but not of other nucleobases. urate(out) = urate(in) Highly expressed in the intestine, with high expression in the jejunum and ileum, the segments of the intestine that perform the majority of urate excretion (PubMed:25100214). Isoform 1: Widely expressed (PubMed:16293642). Isoform 1: In kidney, expressed at low levels in proximal tubules (PubMed:19587147). Isoform 2: Primarily expressed in liver and kidney; with specific expression in distal convoluted and connecting tubules of kidney (PubMed:16293642, PubMed:19587147). N-glycosylated. Conditional knockout mice lacking Slc2a9 in enterocytes are born at the expected Mendelian rate; they show no obvious phenotype and are fertile (PubMed:25100214). Mice however develop impaired enterocyte uric acid transport kinetics, hyperuricaemia, hyperuricosuria, spontaneous hypertension, dyslipidaemia and elevated body fat (PubMed:25100214). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. High-capacity urate transporter that was first described as a fructose and glucose transporter. Also described in the literature as high-affinity and low-capacity glucose and fructose transporter (By similarity). However, another group could not confirm transporter activity for glucose or fructose (By similarity).