Regulates both neuronal polarity and synaptic organization when bound to strd-1. Kinase activity is required for the establishment, but not the maintenance, of both processes. Binding to nab-1 is essential for role in restricting axonal fate during neuronal polarization but is not required for regulating synapse morphology. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Interacts with strd-1 and nab-1. Synapse localization is regulated by strd-1. Co-localizes with strd-1 in synapses. Expressed in neurons. Colocalizes with strd-1 along the dorsal nerve cord. Pre-synaptic vesicle and active zone proteins fail to be restricted to the axons of motor and sensory neurons. Synaptic vesicles fail to form tight clusters implying aberrant synaptic organization in addition to defects in neuronal polarity. Overexpression causes mislocalization of vesicle proteins to dendrites. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.