Promotes cell proliferation. Modulates apoptotic pathways. Increases mitogen-activated protein kinase activity. Important for cell migration, and for normal structure and assembly of the Golgi complex. Important for KDR/VEGFR2 signaling. Required for normal angiogenesis, vasculogenesis and hematopoiesis during embryonic development (By similarity). Required for normal cardiovascular development (PubMed:19370760). Interacts (via C-terminus) with CCM2. Interacts (via N-terminus) with STK25 and STK26. Belongs to the PDCD10 family.