Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation. Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. Expressed at high levels in heart, mammary gland, adrenal gland, stomach, smooth muscle and skeletal muscle, and at lower levels in brain and lung. Strongly down-regulated in lung cancer tissues, due to hypermethylation of the corresponding locus (PubMed:12660825). Expressed in adipose tissue (PubMed:26629404). Expressed in fetal brain. Belongs to the CD225/Dispanin family.