Insect active toxin causing rapid but reversible paralysis in crickets. No activity shown in mammals. Suppresses the excitatory postsynaptic potentials evoked in lobster neuromuscular synaptic preparations, possibly by blocking the presynaptic calcium channel. Induces instantaneous reversible paralysis when injected into crickets. Does not show effect on mammalian Cav2.1/CACNA1A, Cav2.2/CACNA1B and Cav2.3/CACNA1E (By similarity). Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. The primary structure of the mature peptide is identical to that of U2-agatoxin-Aop1a (Agelenin) from Allagelena opulenta (AC P31328). Belongs to the neurotoxin 01 (U2-agtx) family.