Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation. Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. Present in adipose tissue and undetectable in other tissues (at protein level). Up-regulated during differentiation in primary cultured rat brown preadipocytes. Down-regulated upon cold exposure in brown adipose tissue in Zucker lean rats. Down-regulated by dexamethasone. Belongs to the CD225/Dispanin family.