Plays a role in intermediary metabolism and energy production (PubMed:22416140, PubMed:19228619). It may tightly associate or interact with the pyruvate dehydrogenase complex (PubMed:22416140, PubMed:19228619). D-threo-isocitrate + NADP(+) = 2-oxoglutarate + CO2 + NADPH Binds 1 Mg(2+) or Mn(2+) ion per subunit. Homodimer. Acetylation at Lys-413 dramatically reduces catalytic activity. Deacetylated by SIRT3. The disease is caused by variants affecting the gene represented in this entry. The gene represented in this entry is involved in disease pathogenesis. enetic variations are associated with cartilaginous tumors such as enchondroma or chondrosarcoma. Belongs to the isocitrate and isopropylmalate dehydrogenases family.