Endothelins are endothelium-derived vasoconstrictor peptides (PubMed:2451132). Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells (By similarity). Also binds the DEAR/FBXW7-AS1 receptor (By similarity). Belongs to the endothelin/sarafotoxin family.