Microtubule-associated protein required for mitotic spindle formation and cell-cycle progression in neural progenitor cells. Uniformly distributed along each microtubule bundle of spindles in addition to centrioles during mitosis, expression promptly diminishes at interphase. Highly expressed in regions of active neurogenesis and neural stem/progenitor cells (NSPCs), both embryonic and adult, not detected in lung, liver, kidney, heart, and skeletal muscle. At 10.5 dpc, strongly expressed in the neural progenitor cells throughout the neural tube and in the myotome. Expression is significantly lower in connective tissues compared to neural tube, but can be detected at the mitotic spindles of dividing mesenchymal cells loosely distributed in the developing limb bud. In an 12.5 dpc forelimb bud, detected in the dividing cells at the boundary region between protruding cartilage and surrounding mesenchyme (at protein level). The KEN box is required for the association with the APC/C-Cdh1 complex, ubiquitination and degradation. Ubiquitinated by the anaphase promoting complex/cyclosome (APC/C). Belongs to the CKAP2 family.