Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons (PubMed:11406114). Important for normal acidification of the endosome lumen. May play an important role in renal tubular function (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The absence of conserved gating glutamate residues is typical for family members that function as channels (Probable). 2 chloride(in) + H(+)(out) = 2 chloride(out) + H(+)(in) Interacts with NEDD4 and NEDD4L. Detected in duodenum, jejunum and ileum. Detected in crypt and villus regions of the epithelium of the small intestine. Ubiquitinated by NEDD4L in the presence of albumin; which promotes endocytosis and proteasomal degradation. Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.