Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis. Interacts with ARRDC3. White and brown adipose tissues, and digestive tract. The guinea pig differs from other rodents by an absence of beta-3 adrenergic effects and by low expression in brown and white adipose tissues. It is closer to human or primate than rodent beta-3. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB3 sub-subfamily.