Required specifically for chromosome disjunction during all mitoses; maternally provided protein is sufficient until mitosis 14 then zygotic protein is required. Involved in formation and/or maintenance of epithelial structures: bud extension during Malpighian tubule development, and foregut and hindgut morphogenesis. Interacts with pim and Sse. Cleavage of thr contributes to inactivation of Sse. Cytoplasmic during interphase and distributed throughout the cell during early mitosis. During embryogenesis, expressed in Malpighian tubule buds, and epithelia of foregut and hindgut. Expressed both maternally and zygotically. Proteolytically cleaved after the metaphase-to-anaphase transition, C-terminal cleavage product is degraded. Cleavage can only proceed within complexes that contain active Sse. Intron retention.