Involved in vision. Interacts with RHO/rhodopsin; the interaction promotes PRCD stability. Localizes to photoreceptor disk membranes in the photoreceptor outer segment. Expressed in retina. Palmitoylated at Cys-2. Palmitoylation is essential for protein stability and trafficking to the photoreceptor outer segment, but does not appear to be essential for membrane localization. Probably palmitoylated by ZDHHC3. Phosphorylated. Defects in PRCD are the cause of progressive rod-cone degeneration (PRCD) (PubMed:16938425). PRCD is the most widespread hereditary retinal disease leading to blindness in dogs and phenotypically is the canine counterpart of retinitis pigmentosa in humans (PubMed:16938425). Belongs to the PRCD family.