RNA-binding protein that initiates the antiviral response and is required to restrict the replication of RNA viruses (PubMed:33872655). Acts as a double-stranded RNA (dsRNA) sensor that recognizes viral RNA and then interacts with MAVS to initiate the type I interferon response (By similarity). Also required for immunity against some bacteria, such as mycobacteria (PubMed:33876776). Interacts with MAVS. Widely expressed. The disease is caused by variants affecting the gene represented in this entry. Belongs to the ZNFX1 family. Truncated C-terminus.