Negatively regulates TNF-alpha-induced pro-inflammatory response in endothelial cells (ECs) via inhibition of TNF-alpha-induced NF-kappaB activation in ECs (By similarity). Positively regulates lipid accumulation in adipose cells (PubMed:25605713). Homodimer. Expressed in aorta and adipose tissue. Enriched in mature adipocytes. Over-expressed in adipose tissue from either hormonally-induced or nutritionally-regulated obese mice models. N-glycosylated. Mice exhibit a lean phenotype with reduced fat mass and smaller adipocyte size compared to wild type mice. Adipose tissue exhibit decreased levels of lipogenic genes, such as fatty-acid synthase (FASN), acetyl-CoA carboxylase (ACACA) and diacylglycerol O-acyltransferase-2 (DGAT2). Mice exhibit strongly inhibited age-related hepatic steatosis and decreased number of inflammatory cells in epididymal adipose tissue.