(6S)-5-methyl-5,6,7,8-tetrahydrofolate + NADP(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADPH (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD(+) = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + H(+) + NADH One-carbon metabolism; tetrahydrofolate interconversion. Present with 8600 molecules/cell in log phase SD medium. Belongs to the methylenetetrahydrofolate reductase family. Was originally thought to be a mitochondrial ribosomal protein. Sequencing errors. Sequencing errors.