Pleiotropic ABC efflux transporter involved in the protection of the cells against a wide range of toxic compounds (PubMed:10954082). Confers resistance to the azole fenarimol via efflux transport (PubMed:10954082). May also be involved in the secretion of penicillin (PubMed:10954082). Fenamirol efflux transporter activity is inhibited by the cyclosporin derivative PSC 833, nigericin, reserpine and valinomycin (PubMed:10954082). The effect of reserpine is transiant, while that of the cyclosporin derivative PSC 833, nigericin and valinomycin is proportional to the time of exposure (PubMed:10954082). Cyclohexinmide has inhibitory effect only when applied prior to addition of the fungicide (PubMed:10954082). Expression is strongly increased in the presence of cycloheximide, camptothecin, imazalil, itraconazole, hygromycin and 4-nitroquinoline oxide (4-NQO). Leads to the cellular accumulation of fenarimol (PubMed:10954082). Leads to increased susceptibility to cycloheximide, the cyclosporin derivative PSC 833, nigericin and valinomycin (PubMed:10954082). Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.