May function as antiviral protein and may contribute to the defense against retroviral infections. Homotrimer. Interacts (via the B30.2/SPRY domain) with HIV-1 capsid complexes (PubMed:17156811). Interacts (via B-box and SPRY domain) with TRIM5 (PubMed:21680743, PubMed:17156811). Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. Up-regulated by interferons. Belongs to the TRIM/RBCC family. The in vivo relevance of this transcript of the TRIM6 (AC Q9C030) and TRIM34 genes creating a chimeric protein of 842 residues is uncertain.