Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection (PubMed:25147569, PubMed:25369374). Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). Interacts with various phosphatidylinositol phosphates, such as phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P), phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P), phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P), and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P) (PubMed:25147569). H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide Interacts with host MYD88. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.