Plays an important role in normal erythropoiesis (By similarity). It has a role in the differentiation of erythroid progenitors (By similarity). Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Mediates docking of ADAM10 to zonula adherens by interacting with ADAM10 and, in a PDZD11-dependent manner, with the zonula adherens protein PLEKHA7 (By similarity). Homodimer; disulfide-linked (By similarity). Interacts (via extracellular domain) with ADAM10 (via extracellular domain) (PubMed:23035126). Interacts (via cytoplasmic domain) with PLEKHA7 (via WW domains); the interaction is dependent on PDZD11 being bound to PLEKHA7 and facilitates the docking of ADAM10 to zonula adherens (By similarity). Is localized to zonula adherens by PLEKHA7 by a PDZD11-dependent interaction. Belongs to the tetraspanin (TM4SF) family.