Regulates the cell cycle in a nutrient dependent manner. Accumulates in presence of nutrients and directs the destabilization of DMA1 and DMA2, whose accumulation results in a G1 block. Regulates also the abundance of GCD11 an essential component of the translational initiation factor 2 (By similarity). Interacts with DMA1, DMA2 and GCD11. Belongs to the CDC123 family.