Pleiotropic ABC efflux transporter involved in the basal level of drugs susceptibility, including antibiotics, azole fungicides and plant defense toxins (PubMed:9180695). Confers resistance to cycloheximide, chloramphenicol, imazalil, sulfomethuron methyl, pyrimethanil, quintozene, acriflavine, rhodamine 6G, the azoles fenarimol and miconazole, and to the dicarboximides iprodione and vinchlozolin (PubMed:9180695, PubMed:10931903). ATP + cycloheximide(in) + H2O = ADP + cycloheximide(out) + H(+) + phosphate ATP + chloramphenicol(in) + H2O = ADP + chloramphenicol(out) + H(+) + phosphate Expression is strongly increased in the presence of cycloheximide, imazalil, fenarimol, pisatin, itraconazole and 4-nitroquinoline oxide (4-NQO). Leads to increased sensitivity to different classes of agricultural fungicides: cyprodinil (anilinopyrimidine), ketoconazole, prochloraz and propiconazole (azoles), carbendazim (a benzimidazole), fenpiclonil and fludioxonil (phenylpyrroles), fluazinam (a phenylpyridianine), azoxystrobin, kresoxim-methyl and trifloxystrobin (strobirulins), 4-nitroquinoline oxide (a mutagenic agent), camptothecin (a plant alkaloid) and the phytoalexin resveratrol (a stilbene). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.