Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. Involved in the reorganization of late endosome/lysosome (LE/Lys) compartments in mammalian cells. Necessary and sufficient to link kinesin-1 onto the Salmonella-containing vacuole (SCV) membrane. Required for centrifugal extension of lysosomal glycoprotein-rich membrane tubules, known as Salmonella-induced filaments (Sifs), away from the SCV and toward the cell periphery. Required for virulence, but not for intracellular survival and replication in phagocytic cells. Interacts with the host kinesin light chain (KLC), a subunit of the kinesin-1 motor complex. Secreted via the type III secretion system 2 (SPI-2 TTSS), and delivered into the host cell. In phagocytic cells localizes to the Salmonella-containing vacuole (SCV) and tubular extensions from the SCV, Salmonella-induced filaments (Sifs). In epithelial cells localizes to peripheral vesicles, in addition to SCVs and Sifs. Concentrates in detergent-resistant microdomains (DRMs), present on the intracellular membranes of SCVs and Sifs. Expression of the gene is regulated by the two-component regulatory system SsrA/SsrB. It is also activated by SlyA and controlled by the two-component regulatory system PhoP/PhoQ. Contains various tandem pentapeptide repeats in the C-terminal region. The pentapeptide motif is required to efficiently recruit kinesin-1. No position is completely conserved in these repeats, whose consensus sequence is A-[DN]-[FLM]-X-X. The C-terminal 38 amino acid residues, specifically, the C-terminal motif LFNEF, are required for peripheral localization of PipB2 and redistribution of lysosomal-associated membrane protein (LAMP). The N-terminal 225 amino acid residues are sufficient for type III translocation and association with Sifs and SCVs, but not accumulation in peripheral vesicles.