In contrast to other members of the CCAP family which are cardio-accelerators, conoCAP-a decreases the heart frequency in Drosophila larvae (26%), rats and zebrafish embryos. It also reduces the blood pressure in rats. It decreases systolic calcium in ventricular cardiac myocytes, indicating that it may act via impairment of intracellular calcium trafficking. Synthetic conoCAP-b decreases the heart frequency of 23% in Drosophila larvae. Synthetic conoCAP-c decreases the heart frequency of 12% in Drosophila larvae. Expressed by the venom duct. Monoisotopic.