Precursor protein for pituitary hormones that regulate stress and environmental adaptation. Stimulates the adrenal glands to release cortisol. Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Alpha-MSH and beta-endorphin are stored in separate granules in hypothalamic POMC neurons, suggesting that secretion may be under the control of different regulatory mechanisms. Belongs to the POMC family.