Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Regulates synapse elimination in early development in the motor neuron HSNL. Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis. May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation. Involved in sex determination by promoting female development. Potential regulator of presenilin. May have a role in egg laying. Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis. Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation. Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex which includes skr-1 and F-box domain-containing protein sel-10 as a substrate recognition component. Interacts with fem-1, fem-2, and fem-3. Interacts with the intracellular domain of glp-1 and sel-12. Interacts with lin-12. Interacts with skr-1. Interacts with zyg-1. Expressed throughout the axon throughout development.