Cell-surface glycoprotein having a role in immunoadhesion (PubMed:11529941). Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity). Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction. Up-regulated in endothelial cells after exposure to bacterial lipopolysaccharide (LPS). Belongs to the selectin/LECAM family.