Plays a role in actin cytoskeleton rearrangement. The soluble form promotes endothelial cell migration and filopodia formation during sprouting angiogenesis via a FAK-dependent mechanism. Detected on podocyte foot processes. Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. Detected on kidney podocytes along the glomerular capillary wall (at protein level). Sequence analysis combined with the expression of constructs corresponding each to two or three adjacent TSP type-1 domains suggests the presence of 21 TSP type-1 domains; not all of these are detected by standard bioinformatic tools. Proteolytic cleavage in the extracellular region generates a 210 kDa soluble form. Extensively N-glycosylated.