Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil. Monomer. Interacts with FAM72A. (Microbial infection) Interacts with HIV-1 Vpr. Isoform 1 is widely expressed with the highest expression in skeletal muscle, heart and testicles. Isoform 2 has the highest expression levels in tissues containing proliferating cells. Isoform 1 is processed by cleavage of a transit peptide. The disease is caused by variants affecting the gene represented in this entry. Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family. UNG mutation db