(S)-malate + NAD(+) = H(+) + NADH + oxaloacetate Homodimer. Yeast contains at least 3 malate dehydrogenase isoenzymes: a mitochondrial (MDH1), a cytoplasmic (MDH2) and a peroxisomal (MDH3). Present with 28100 molecules/cell in log phase SD medium. Belongs to the LDH/MDH superfamily. MDH type 1 family.