Alpha-D-conopeptides act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin specifically blocks mammalian neuronal nAChR of the alpha-7/CHRNA7 (IC(50)=0.25 nM), alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=2.8 nM), and alpha-4-beta-2/CHRNA4-CHRNB2 (IC(50)=28.6 nM) subtypes. Has no effect on alpha-3-beta-4/CHRNA3-CHRNB4, alpha-4-beta-4/CHRNA4-CHRNB4 and alpha-1-beta-1-epsilon-delta/CHRNA1-CHRNB1-CHRNE-CHRND subtypes of nAChRs. Hetero-, homo- or pseudo-homodimers (identical sequence, different post-translational modifications). Expressed by the venom duct. The cysteine framework is XX (C-CC-C-CC-C-C-C-C). Contains 5 disulfide bonds. Belongs to the conotoxin D superfamily.