Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (PubMed:23532839). Seems to act as potassium channel regulator and may inhibit pain signaling; can facilitate KCNT1/Slack channel activity by promoting its full single-channel conductance at very low sodium concentrations and by increasing its sodium sensitivity (PubMed:23872594). a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) Interacts with KCNT1/Slack. Shows an intracellular localization. Predominantly expressed in neuronal tissues. Expressed in brain. In the developing gastrointestinal tract, expressed in the intestinal epithelium at 14.5 dpc and in an incomplete ring of cells in the mesenchyme of the esophagus, stomach and small intestine at 16.5 dpc. In the developing skeleton, expressed in the perichondria of the neural arch of developing vertebrae at 14.5 dpc and 16.5 dpc. At 14.5 dpc, also expressed in perichondria of developing ribs. At 14.5 dpc and 16.5 dpc, detected in dorsal root ganglia and neural tube. In developing skin, expression is detected in the most suprabasal layers at 16.5 dpc. Not detected in the lung at 14.5 dpc or 16.5 dpc. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family.