Suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. The P0 protein suppresses local PTGS using its F-box-like domain to mediate destabilization and degradation of the AGO1 protein. Interacts (via F-box-like domain) with host AGO1; this interaction targets AGO1 for degradation, and thereby suppresses the silencing function of the latter. Interacts (via F-box-like domain) with host ASK1 and ASK2 (SKP proteins); these interactions are essential for viral pathogenicity. Part of a SCF P0 complex composed of P0 and the host proteins SKP and CUL1. Belongs to the polerovirus P0 protein family. The publication has been retracted because some figures presented signs of inappropriate manipulation.