Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin inhibits the inactivation of activated TTX-sensitive sodium channels (Nav). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). LD(50) is 0.088 ug/g by subcutaneous injection into mice, 0.0023 ug/g by intracerebroventricular injection into mice and 14.3 ug/g in B.germanica. Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.