Regulates renal phosphate excretion (By similarity). Regulates bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (By similarity). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Increases dental pulp stem cell proliferation. Interacts (via ASARM motif) with PHEX; the interaction is zinc-dependent. Expressed in osteoblasts and osteocytes. Induced by dexamethasone. The acidic serine aspartate-rich MEPE-associated (ASARM) motif is sufficient when phosphorylated to inhibit bone mineralization by osteoblasts and cartilage mineralization by chondrocytes by binding hydroxyapatite crystals during the mineralization stage. It can also inhibit dentin mineralization. The dentonin region is sufficient to promote dental pulp stem cell proliferation. It can also stimulate bone formation, osteoblast differentiation, and activate integrin signaling pathways. Phosphorylated on serine residues in the ASARM motif; the phosphorylation is important for the inhibition of bone mineralization. Cleaved by CTSB/cathepsin B; the cleavage is blocked by metalloprotease PHEX. Belongs to the PF07175/osteoregulin family.