Seems to play a role in p53-mediated apoptosis induction (PubMed:17380123). Binds to NR1D2 and relieves it of its inhibitory effect on the transcription of APOC3 without affecting its DNA-binding activity (PubMed:17892483). Interacts with MAPK11 and MAPK14 (PubMed:17380123). Component of the chromatin-remodeling SRCAP complex composed of at least SRCAP, DMAP1, RUVBL1, RUVBL2, ACTL6A, YEATS4, ACTR6 and ZNHIT1 (PubMed:15647280). Interacts with NR1D1 and NR2D2 (PubMed:17892483). Interacts (via HIT-type zinc finger) with the RUVBL1/ RUVBL2 complex in the presence of ADP (PubMed:28561026). Expressed abundantly in liver, but weakly in skeletal muscle, ovary and small intestine. Induced by DNA damage. Phosphorylated on Thr by MAPK11 or MAPK14. Stres-induced ZNHIT1 is mainly regulated at the level of protein. Belongs to the ZNHIT1 family.