Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762, PubMed:30442766, PubMed:30481304). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes (PubMed:30442762, PubMed:30442766, PubMed:30481304). Protein modification; protein ubiquitination. Homodimer (PubMed:30442762). Component of the BCR(LZTR1) E3 ubiquitin ligase complex, at least composed of CUL3, LZTR1 and RBX1 (PubMed:30442762, PubMed:30442766). Interacts with Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS) (PubMed:30442762). Interacts with RAF1 (PubMed:30368668). Interacts with SHOC2 (PubMed:30368668). Interacts with PPP1CB (PubMed:30368668). Expressed in fetal brain, heart, kidney, liver and lung. Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome. The protein represented in this entry may be involved in disease pathogenesis. Disease susceptibility is associated with variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease may be caused by variants affecting the gene represented in this entry. Belongs to the LZTR1 family.