Required for pre-mRNA splicing as component of the spliceosome (By similarity). Binds double-stranded RNA. Inhibits EIF2AK2 kinase activity. Component of the pre-catalytic and post-catalytic spliceosome complexes (By similarity). Interacts with EIF2AK2. Broadly expressed, with highest levels in liver, kidney, brain and heart. By IL11. Belongs to the PRKRIP1 family.