May play a major role in the structural organization and calcification of developing enamel (PubMed:18252228). May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration (PubMed:23902688). Interacts with CSNK1A1; recruits CSNK1A1 to keratin filaments. Interacts with KRT18 and probably other keratins. Colocalizes with keratin filaments. Expressed in the tooth follicle. The disease is caused by variants affecting the gene represented in this entry. Belongs to the FAM83 family. Truncated N-terminus.