Receptor for corticotropin (ACTH). This receptor is mediated by G proteins (G(s)) which activate adenylate cyclase (cAMP). Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH). Melanocytes and corticoadrenal tissue. The disease is caused by variants affecting the gene represented in this entry. Belongs to the G-protein coupled receptor 1 family.