(R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA kcat is 240 sec(-1) for (S)-methylmalonyl-CoA epimerization. Highly thermostable: is fully active after 60 minutes at 100 degrees Celsius and loses less than 10 per cent of its activity after 100 minutes at the same temperature. Belongs to the methylmalonyl-CoA epimerase family.