Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate Down-regulated by Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection. Belongs to the ATP-dependent AMP-binding enzyme family.