Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Interacts with ATP6AP2. Associated to membranes via binding to ATP6AP2. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the peptidase A1 family. Renin entry