Highly expressed in the brain and eye during development (PubMed:32885237). Expressed in olfactory bulbs (at protein level) (PubMed:10708520). Knockout animals show significantly reduced viability. Homozygous knockout mice also weigh significantly less than their wild-type or heterozygous littermates. These mice also display severe developmental eye defects, including anophthalmia, microphthalmia, and cataract, and the presence of these phenotypes is significantly increased compared to wild-type or heterozygous mice. Belongs to the peptidase C2 family.