Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of pseurotin and fumagillin (PubMed:24116213). Expression is under the control of the developmental and secondary metabolism regulators laeA and veA (PubMed:24082142, PubMed:24116213). Results in silencing of the fumagillin gene cluster and elimination of fumagillin biosynthesis (PubMed:24116213). Fumagillin and its derivatives have been intensely studied for their potential use in the treatment of amebiasis, microsporidiosis and rheumatoid arthritis (PubMed:14913169, PubMed:12075057, PubMed:18209961). They have also interesting antiangiogenic properties by the irreversible inhibition of human type 2 methionine aminopeptidase (METAP2) (PubMed:9177176).