Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. a beta-lactam + H2O = a substituted beta-amino acid Binds 2 Zn(2+) ions per subunit. Inhibited by chelating agents such as EDTA, 1-10 phenanthroline and pyridine-2,6-dicarboxylic acid. kcat is 350 sec(-1) for lactamase activity with imipenem as substrate. kcat is 300 sec(-1) for lactamase activity with 6-beta-iodopenicillanate as substrate. kcat is 280 sec(-1) for lactamase activity with penicillin G as substrate. kcat is 39 sec(-1) for lactamase activity with cefotaxime as substrate. kcat is 17 sec(-1) for lactamase activity with nitrocefin as substrate. kcat is 14 sec(-1) for lactamase activity with cephaloridine as substrate. kcat is 6 sec(-1) for lactamase activity with cefoxitin as substrate. Monomer. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.