Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network (PubMed:30262884). Signaling adapter which plays a role in neuronal differentiation (PubMed:15024033). Involved in regulation of NGF-dependent neurite outgrowth (PubMed:15024033). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK (PubMed:15024033). Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (PubMed:19365808). Associated component of the adapter-like complex 4 (AP-4) (PubMed:30262884). Interacts with IKBKG and TRAF6 (PubMed:19365808). Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (By similarity). Translocated to the nuclear envelope upon stimulation with NGF (PubMed:15024033). Associated with membranes and microtubules (By similarity). Predominantly expressed in brain. The RUN domain is necessary for NGF induced nuclear redistribution. Phosphorylated on serine residues following nuclear translocation. Polyubiquitinated; polyubiquitination involves TRAF6. Truncated N-terminus. Truncated N-terminus.