Binds phosphatidylinositol 4,5-bisphosphate (PIP2). May play a role in the organization of nuclear PIP2, cell division and cell survival. Monomer and homodimer. Interacts with SDCBP (PubMed:11152476). Interacts with TM4SF1. Associates with intracellular membranes and enriched in the apical region of the cell and in intracellular compartments. Colocalizes with TM4SF1 in the apical region of the cell. Predominantly targeted to nuclear PIP2 pools. Shuttles between several subcellular compartments. PIP2 plays an important role in the distribution of SDCBP2. The two PDZ domains mediate the interaction with phosphatidylinositol 4,5-bisphosphate (PIP2) and target SDCBP2 to the plasma membranes and nucleoli, PIP2-rich regions.