Molecular adapter that acts as a bridge between proteins, and which is involved skeletal muscle development (PubMed:18255059, PubMed:19406121, PubMed:30746755). Functions as signal transducer for MSTN during skeletal muscle regeneration and myogenesis (PubMed:18255059, PubMed:19406121). May regulate chemotaxis of both macrophages and myoblasts by reorganising actin cytoskeleton, leading to more efficient lamellipodia formation via a PI3 kinase dependent pathway (PubMed:19406121). In contrast to AKIRIN2, not involved in nuclear import of proteasomes (By similarity). Expressed in macrophages and satellite cells. Up-regulated in activated satellite cells and in the regenerating muscle (PubMed:19406121). Down-regulated by MSTN in skeletal muscle (PubMed:19406121, PubMed:18255059, PubMed:23516508). Down-regulated by dexamethasone by a MSTN (PubMed:23516508). Mice grow normally and do not display gross developmental abnormalities (PubMed:18066067). Embryonic fibroblasts obtained from null mutant mice do not express Akirin1 (PubMed:18066067). 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal. Belongs to the akirin family.