Orphan nuclear receptor (PubMed:10022975). Transcriptional repressor of intestinal metal transporter smf-3 and genes of the innate immune response (PubMed:31532389). Inhibits nuclear localization of transcription factor pqm-1; in response to pathogen stress, may facilitate translocation of pqm-1, leading to transcriptional activation of genes involved in innate immunity and iron uptake (PubMed:31532389). Expressed in intestine and head neurons in young adults. RNAi-mediated knockdown causes enhanced resistance to infection with the Gram-negative bacterium P.aeruginosa (PubMed:31532389). Knockdown suppresses the developmental delay phenotype of hif-1 mutants when grown under iron limiting conditions (PubMed:31532389). Belongs to the nuclear hormone receptor family.