Plays a major role in decreasing resistance to glycopeptide antibiotics. Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion. Transcriptionally regulated by the vraSR two-component system in response to cell wall antibiotics, such as teicoplanin, vancomycin, and oxacillin. Belongs to the TcaA family.