Involved in tumorigenesis and may function by stabilizing p53/TP53. Interacts with LETMD1 (PubMed:17943721). Interacts with BRI3 (isoforms 1 and 2); the interaction with isoform 2 is weaker than with isoform 1 (PubMed:11860200, PubMed:30983867). Interacts with BRI3; the interaction is weak (PubMed:30983867). Most abundantly expressed in brain, liver and kidney (PubMed:11860200). Overexpressed in leukemia and lymphoma cell lines, as well as in various carcinomas (PubMed:17943721).