Heme transporter required for the export of intestinal heme to different tissues and subcellular compartments (PubMed:24836561, PubMed:28581477). Also, required for the export of vitamin B12 from the intestine of the mother to the embryo to support embryonic development (PubMed:29562169). Highly expressed in the intestine and pharynx (PubMed:24836561, PubMed:29562169). Expressed at low levels in the hypodermis and in some neurons (PubMed:24836561). Expressed throughout development. RNAi-mediated knockdown in larvae does not result in any obvious developmental defects and animals are able to reach the adult gravid stage and lay eggs (PubMed:24836561). However, 80% of the eggs laid fail to hatch, and the animals that hatch do not survive beyond the L1 larval stage (PubMed:24836561). RNAi-mediated knockdown in larvae results in the heme accumulation in the intestine under low heme conditions (PubMed:28581477). RNAi-mediated knockdown in larvae results in an accumulation of vitamin B12 in the intestine and defective vitamin B12 transport from mother to dead embryos (PubMed:29562169). Furthermore, embryos of RNAi-treated mothers also have defects in vitamin B12 metabolism and have reduced levels of methionine and S-adenosylmethionine (PubMed:29562169). Double RNAi-mediated knockdown with hrg-7 in larvae results in defective heme sensing (PubMed:28581477). Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.