Hydrolyzes 3',5'-bisphosphonucleosides (pGp, pCp, pUp, and pIp) to nucleoside 5'-phosphate and orthophosphate. Has similar catalytic efficiencies with all the bases. Also shows activity with ribonucleoside 2'-deoxyribonucleoside 3',5'-bisphosphates. Does not show activity with nucleoside 2',5'-bisphosphates. a ribonucleoside 3',5'-bisphosphate + H2O = a ribonucleoside 5'-phosphate + phosphate Binds 3 Mn(2+) ions per subunit. kcat is 22 sec(-1) for pAp. kcat is 7.1 sec(-1) for 2'-deoxy-pAp. kcat is 8.6 sec(-1) for pCp. kcat is 9.4 sec(-1) for 2'-deoxy-pCp. kcat is 12.3 sec(-1) for pGp. kcat is 4.2 sec(-1) for 2'-deoxy-pGp. kcat is 5.4 sec(-1) for pUp. kcat is 5.2 sec(-1) for 2'-deoxy-pUp. kcat is 3.3 sec(-1) for pTp. kcat is 4.3 sec(-1) for 2'-deoxy-pIp. kcat is 0.05 sec(-1) for pApA. kcat is 11.6 sec(-1) for N(6)-methyl-3',5'-pAp. Monomer. Belongs to the PHP family.