May be involved in early DNA damage response. Isoform 2 interacts with NEK6. Colocalizes with NEK6 in the centrosome. In response to DNA damage, translocates from the cytosol to mitochondria and nucleus in a reactive oxygen species (ROS)-dependent manner. Expressed in bone marrow (at protein level). Phosphorylated by NEK6. The disease is caused by variants affecting the gene represented in this entry. Belongs to the SNF2/RAD54 helicase family. Truncated N-terminus. Truncated N-terminus.