Potent antimicrobial peptide with activity against bacteria and protozoa (By similarity). Also has activity against fungi (PubMed:8306981). Also shows activity against enveloped herpes simplex virus type 1 (PubMed:11782932). Probably acts by disturbing membrane functions with its amphipathic structure (Probable). Binds to healthy erythrocytes (this binding is receptor independent), and has strong hemolytic activity (PubMed:9395500). Does not bind to P.falciparum infected erythrocytes, but accumulates within the parasite (PubMed:9395500). Kills the parasite, and only at high concentrations has a hemolytic activity on the host cell (PubMed:9395500). In vitro, shows high spermicidal activities (PubMed:16307969). Monomer and oligomer. Forms aggregates in aqueous environments. Expressed by the skin glands. Derivatives of this peptide may be used as therapeutic agents to treat bacterial infections and malaria, and to prevent infection by herpes simplex virus type 1 and HIV-1. May be used as a potent vaginal contraceptive, since it shows spermicidal activities. Belongs to the frog skin active peptide (FSAP) family. Dermaseptin subfamily.