Functions as a fructose transporter that has only low activity with other monosaccharides (PubMed:26416735, PubMed:8333543, PubMed:9820812). Can mediate the uptake of deoxyglucose, but with low efficiency (PubMed:8333543). Essential for fructose uptake in the small intestine (By similarity). Plays a role in the regulation of salt uptake and blood pressure in response to dietary fructose (By similarity). Required for the development of high blood pressure in response to high dietary fructose intake (By similarity). D-fructose(out) = D-fructose(in) Fructose uptake is inhibited by mercury ions (PubMed:26416735). Fructose uptake is only slightly inhibited by cytochalasin B (PubMed:8333543, PubMed:9820812). Localized on the apical membrane of jejunum villi, but also on lateral plasma membranes of the villi. Transport to the cell membrane is dependent on RAB11A. Detected in jejunum (PubMed:8404647, PubMed:9820812). Detected in kidney, skeletal muscle, brain and adipose tissue (at protein level) (PubMed:9820812). Detected in small intestine and in kidney, and at much lower levels in brain. Detected in enterocytes in duodenum, jejunum, and ileum (PubMed:8333543). Detected in small intestine during embryogenesis, but expression is much higher in adult. Up-regulated in jejunum by a diet with a high fructose content (at protein level) (PubMed:8404647, PubMed:9820812). Up-regulated in kidney by a diet with a high fructose content (at protein level) (PubMed:9820812). Up-regulated in jejunum by a diet with a high fructose content (PubMed:8404647). Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.