E3 ubiquitin ligase that acts as a key regulator of DNA repair in response to replication stress (PubMed:31545170, PubMed:30849395). Acts by mediating ubiquitination of the CMG helicase complex, promoting the unloading of the CMG helicase complex by the p97 ATPase (cdc-48.1 or cdc-48.2) (PubMed:31545170, PubMed:30849395). S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Belongs to the TRAIP family.