Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (PubMed:31734253). This toxin acts on human Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.4/SCN4A and Nav1.6/SCN8A voltage-gated sodium channels (PubMed:31734253). Also, it reduces the peak of sodium currents in Nav1.5/SCN5A at all potentials (PubMed:31734253). In vivo, is lethal to mice when intraperitoneally injected at a dose of 5ug (PubMed:31734253). No activity is observed when injected into crickets or woodlice (PubMed:31734253). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.