Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Interacts (via bromo domain) with acetylated lysine residues on histone H1.4, histone H3 and H4 (in vitro) (By similarity). Interacts with IRS1 and IRS2. Widely expressed with most abundant expression detected in pancreatic islets, brain and skeletal muscle. Predominantly expressed in developing and regenerating neurons. Expressed in adult brain (granular layer of the olfactorium bulb, hippocampus, dentate gyrus and cerebellum internal granular layer). Expressed in the CA3 region of adult hippocampus, adult and fetal retina, perinatal dorsal root ganglion and embryonal olfactory epithelia (at protein level). Expressed at highest levels at 17.5 dpc in the neural layer of the retina and olfactory epithelia. In motor neurons after injury. Intron retention. This sequence is incomplete at the 5' end and extensively differs from that shown. Contaminating sequence. Potential poly-A sequence. Intron retention. This sequence is incomplete at the 3' end and extensively differs from that shown.