Heme-binding protein involved in heme-iron utilization. The ability to acquire iron from host tissues is a major virulence factor of pathogenic microorganisms. Required for biofilm formation. Preferentially expressed during the mycelial growth phase with only low levels of transcript detected in the yeast form. Induced by iron starvation and ciclopirox. Positively regulated by BCR1 and RIM101, and repressed by TUP1. Expression is also regulated by EFG1, CPH1, HAP43, and SEF1. The CFEM domain is involved in heme-binding. It contains 8 cysteines and is found in proteins from several pathogenic fungi, including both human and plant pathogens. The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer. Belongs to the RBT5 family.