Regulator of Src-induced anchorage independent cell growth (By similarity). May have E3 ubiquitin-protein ligase activity. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Interacts with isoform p52shc of SHC1 (By similarity). May form oligomers. Predominantly expressed in the cytoplasm but a fraction is associated with the mitochondria. Up-regulated in gastric adenocarcinomas. Auto-ubiquitinated (in vitro). May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the TRIM/RBCC family.