Involved in the biosynthesis of the anthracyclines carminomycin, rhodomycin, daunorubicin (daunomycin) and doxorubicin (adriamycin) which are aromatic polyketide antibiotics that exhibit high cytotoxicity and are widely applied in the chemotherapy of a variety of cancers. Catalyzes the incorporation of a hydroxyl group at position C-11 of aklavinone, resulting in epsilon-rhodomycinone. aklavinone + H(+) + NADPH + O2 = epsilon-rhodomycinone + H2O + NADP(+) Antibiotic biosynthesis; daunorubicin biosynthesis. Antibiotic biosynthesis; carminomycin biosynthesis. Antibiotic biosynthesis; rhodomycin biosynthesis. Antibiotic biosynthesis; doxorubicin biosynthesis. Monomer. Cells lacking this gene do not produce epsilon-rhodomycinone and accumulate 11-deoxycarminomycin and 11-deoxydaunorubicin. S.peucetius subsp. caesius ATCC 27952, a mutant strain derived from S.peucetius ATCC 29050, is the only organism reported to produce doxorubicin in vivo (PubMed:7961477). Belongs to the PheA/TfdB FAD monooxygenase family.