Has calcium-dependent phospholipid scramblase activity; scrambles phosphatidylserine, phosphatidylcholine and galactosylceramide (PubMed:23532839). Does not exhibit calcium-activated chloride channel (CaCC) activity (By similarity). Can inhibit the activity of ANO1 (By similarity). a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(out) = a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine(in) a 1,2-diacyl-sn-glycero-3-phosphocholine(in) = a 1,2-diacyl-sn-glycero-3-phosphocholine(out) Shows predominantly an intracellular localization with a weak expression in the cell membrane. Predominant expression seen in epithelial tissues. In the developing respiratory system, expression is restricted to the lung epithelium at 14.5 dpc. At 14.5 dpc and 16.5 dpc, expressed in the epithelium of the esophagus, small intestine, stomach and pancreas. At 16.5 dpc, detected in bronchial epithelium. In the developing skeleton, expressed in the perichondria of developing ribs at 14.5 dpc. In developing skin, expression is detected in the most suprabasal layers at 16.5 dpc. The term 'anoctamin' was coined because these channels are anion selective and have eight (OCT) transmembrane segments. There is some dissatisfaction in the field with the Ano nomenclature because it is not certain that all the members of this family are anion channels or have the 8-transmembrane topology. Belongs to the anoctamin family.