Transcription factor required for hyphal growth, biofilm formation, and virulence. Promotes formation of both conventional and pheromone-stimulated biofilms. Binds and recruits HDA1 to promoters of hypha-specific genes in a rapamycin-dependent manner. Involved in the switch between two heritable states, the white and opaque states. These two cell types differ in many characteristics, including cell structure, mating competence, and virulence. Each state is heritable for many generations, and switching between states occurs stochastically at low frequency. Interacts with HDA1. Up-regulation during the yeast-to-hypha transition is dependent upon the function of YAK1. HOG1 represses the expression of BRG1 via the transcriptional repressor SKO1. Regulated by TYE7 during late-stage biofilm formation. Attenuates virulence in a mouse model of systemic infection.