Adapter molecule that plays a key role in the activation of pro-inflammatory NF-kappa-B signaling following detection of bacterial pathogen-associated molecular pattern metabolites (PAMPs) (By similarity). Promotes activation of an innate immune response by inducing the oligomerization and polyubiquitination of TRAF6, which leads to the activation of TAK1 and IKK through a proteasome-independent mechanism (PubMed:16023795). Interacts with traf6. Highly expressed in spleen and moderately expressed in ovary. First detected in the neurula stage and then increased and almost reached a plateau during early tailbud stage. Belongs to the TIFA family.