Final receptor of the SLN1-YPD1-SSK1 two-component regulatory system, which controls activity of the HOG1 pathway in response to oxidative stress and probably also to the osmolarity of the extracellular environment. Involved in cell wall biosynthesis, hyphal growth, and virulence. Regulates the expression of CHK1, as well as of a subset of genes whose functions are associated with cell wall biosynthesis and adaptation to oxidative stress. Provides at least partial adaptive functions for the survival following encounter with human neutrophils. Expression is detected as early as 1 hour after infection of reconstituted human esophageal tissue and increases thereafter up to 48 hours postinfection. Leads to flocculation, attenuated virulence towards reconstituted human esophageal tissue, and to hypersensitivity to fluconazole and voriconazole.