Plays a key role in glycolysis and gluconeogenesis. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Homotetramer. Highly expressed in flowers, and at lower levels in rosettes leaves and cauline leaves. Down-regulated by cadmium (PubMed:16797112). Induced by glucose and sucrose (PubMed:22561114). Induced by drought stress (PubMed:22561114). S-glutathionylated at Cys-68 and Cys-173. S-nitrosylated at Cys-173. Belongs to the class I fructose-bisphosphate aldolase family.