Regulates both fluid phase and receptor-mediated endocytosis (PubMed:12356757, PubMed:12956961). Involved in vesicular transport at a late stage of the secretory pathway (PubMed:8688556). Regulates actin cytoskeleton organization (PubMed:12356757, PubMed:12956961). Interacts (via KKVRF motif) with phosphatase GLC7. Phosphorylation by PRK1 and/or AKL1 on Thr-416, Thr-450 and Thr-490 of repeats 1-1, 1-2 and/or 1-3 negatively regulates SCD5 function in endocytosis and actin cytoskeleton organization. Present with 704 molecules/cell in log phase SD medium.