Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity). The unglycosylated form interacts with PDE4DIP; this interaction, which is PDE4DIP isoform-specific, may connect a pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity). Detected in thyroid (at protein level). Up-regulated by virus infection, double-stranded DNA, IFNG and insulin. Down-regulated by hydrocortisone.