Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known. In an antibody regognizing isoform 2 and isoform 3 has been used. Additional isoforms seem to exist. Expressed in skin interfollicular epidermis and hair follicles. Expressed in tongue epithelium basal suprabasal layers. Expressed in eggs and early embryos. Detected in unfertilized eggs associated with the spindle apparatus and cytoskeletal sheets. As quickly as 5 min after egg activation, relocates to a diffuse peri-spindle position, followed 20-30 min later by localization to the presumptive cytokinetic ring. Before the blastocyst stage of development, associates with the nuclear matrix in a cell cycle-dependent manner, and also associates with the cytoplasmic actin cytoskeleton. After blastocyst formation, is found associating with cell-cell junctions, the cytoskeleton and nucleus. Belongs to the kazrin family. Extended N-terminus.