Role in locomotion and neuronal cell fate specification. Required for the regulation of synaptic density, egg laying, defecation, and meiotic maturation. Required for viability under chronic osmotic stress in which it acts downstream of osr-1. Regulates the synaptic trafficking of glr-1. Bidirectional modulator of neurotransmitter release with negative modulatory effects mainly mediated via slo-1 activation. May suppress the functional response to an internal pacemaker, perhaps by modulating the activity of the IP3 receptor (By similarity). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Ca(2+)/calmodulin binding removes an autoinhibitory regulatory segment located C-terminal to the kinase domain. This releases the catalytic activity of the enzyme and makes accessible a regulatory residue Thr-284. Phosphorylation of Thr-284 by another kinase domain within the oligomeric holoenzyme keeps CaMKII active in the absence of Ca(2+)/calmodulin by preventing the rebinding of the regulatory segment to the kinase domain and by increasing the affinity of calmodulin for the enzyme. Can respond to high-frequency Ca(2+) pulses to become Ca(2+) independent (By similarity). Dodecamer. Subunits are tightly packed around a central ring-shaped scaffold with extensive contacts between the regulatory segment of one kinase and the catalytic domain of another enabling cooperative activation of a subunit by the adjacent molecule. Interacts with and phosphorylates daf-16; the interaction promotes daf-16 nuclear localization. Interacts with egl-2 and tir-1. Interacts with nsy-1. Localizes at or near the Golgi apparatus. Localizes to post-synaptic regions and is enriched in punctate structures in axons of AWC neurons where it co-localizes with tir-1. Localization is regulated by tir-1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.