Catalyzes the reversible ATP-dependent phosphorylation of mevalonate 5-phosphate to produce mevalonate diphosphate and ADP, a key step in the mevalonic acid mediated biosynthesis of isopentenyl diphosphate and other polyisoprenoid metabolites. (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. Monomer. Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. By sterol. The disease is caused by variants affecting the gene represented in this entry. Was originally thought to be located in the peroxisome (PubMed:10191291). However, was later shown to be cytosolic (PubMed:14729858, PubMed:27052676).