Myozenins may serve as intracellular binding proteins involved in linking Z line proteins such as alpha-actinin, gamma-filamin, TCAP/telethonin, LDB3/ZASP and localizing calcineurin signaling to the sarcomere. Plays an important role in the modulation of calcineurin signaling. May play a role in myofibrillogenesis. Interacts via its C-terminus with spectrin repeats 3 and 4 of ACTN2. Interacts with ACTN1, LDB3, MYOT and PPP3CA. Colocalizes with ACTN1 and PPP3CA at the Z-line of heart and skeletal muscle. Expressed specifically in heart and skeletal muscle. The disease is caused by variants affecting the gene represented in this entry. Belongs to the myozenin family.