Together with NovH, involved in the formation of a beta-OH-Tyr intermediate in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases. Acts as a cytochrome P450-type monooxygenase with specificity for the tyrosyl-S-NovH acyl enzyme (L-Tyr-S-NovH) to form the beta-OH-Tyr intermediate (L-beta-OH-Tyr-S-NovH). Antibiotic biosynthesis; novobiocin biosynthesis. Belongs to the cytochrome P450 family.