Component of the intraflagellar transport (IFT) complex B, which is essential for the development and maintenance of motile and sensory cilia. Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity). Interacts with IFT88 (By similarity). Interacts with IFT57 and TTC30B (By similarity). Basal body and ciliary axoneme. Isoform IFT80-L is widely expressed. The disease is caused by variants affecting the gene represented in this entry. Based on a naturally occurring readthrough transcript which produces a TRIM59-IFT80 fusion protein.