Necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity (By similarity). As part of the BCR(KLHL24) E3 ubiquitin ligase complex, mediates ubiquitination of KRT14 and controls its levels during keratinocytes differentiation (By similarity). Specifically reduces kainate receptor-mediated currents in hippocampal neurons, most probably by modulating channel properties (PubMed:17254796). Forms homodimers. Interacts with GRIK2 (PubMed:17254796). Component of the BCR(KLHL24) E3 ubiquitin ligase complex, composed of CUL3, RBX1 and KLHL24. Interacts with CUL3. Interacts with KRT14 (By similarity). Expressed in the brain. In 3-week postnatal brain, prominent in the cortex and in the hippocampus. In the hippocampal formation, detectable in the CA1-CA3 pyramidal cells and in the granule cell layer of the dentate gyrus. In the cerebral cortex, expressed in all layers (I-VI) (at protein level). In 10 week old animals, tends to segregate in CA3 regions. Autoubiquitinated. Autoubiquitination leads to proteasomal degradation and is necessary to control KLHL24 levels.