NAD-dependent protein deacetylase (By similarity). May be involved in the regulation of life span. H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide Binds 1 zinc ion per subunit. Causes lethality during development. Induced silencing shortens life span. Belongs to the sirtuin family. Class I subfamily.