May play a role in microtubule deacetylation by negatively regulating the SIRT2 deacetylase activity toward alpha-tubulin and thereby participate in the control of cell cycle progression and genomic stability. Interacts with alpha-tubulin. Interacts with SIRT2. Also localizes to microtubules. Ubiquitinated and degraded by the proteasome. Belongs to the BEX family.