Weakly inhibits human L-type voltage-gated calcium channel Cav1 (CACNA1S, CACNA1C, CACNA1D, CACNA1F) (IC(50)=4.6 uM). In vivo, it induces reversible paralysis in blowfly L.cuprina. Expressed by the venom gland. C-terminal amidation is necessary for channel blocking activity. PD(50) is 8.9 nmol/g by injection in blowfly. Does not inhibit human L-type voltage-gated calcium channel Cav2 (CACNA1A, CACNA1B, CACNA1E). Belongs to the poneritoxin-Ae1 family.