Regulates insulin-mediated adipose tissue glucose uptake and transport by modulation of SLC2A4 recycling. Not required for SLC2A4 membrane fusion upon an initial stimulus, but rather is necessary for proper protein recycling during prolonged insulin stimulation. Interacts with SLC2A4; the interaction is required for proper SLC2A4 reacycling after insulin stimulation. Shifts from low-density microsome vesicles to the cell membrane upon insulin stimulation. Expressed specifically in white and brown adipose tissues. Target gene of PPARG, expression is induced upon PPARG activation (PubMed:26629404, PubMed:26240143). Expression is inhibited by TNF (PubMed:26240143). Mutant adipocytes show reduced glucose uptake in response to an insulin stimulus (PubMed:26629404). Knockout animals placed on high-fat diet along with wild-type littermates exhibit an increased weight gain, significant elevated blood insulin and glucose levelswith insulin resistance (PubMed:26629404). Belongs to the CD225/Dispanin family.