Putative glycosidase. Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2 (PubMed:19706595). Interacts with IGF2; this interaction is required for IGF2 secretion (PubMed:19706595). Only a minor fraction is present in the peripheral endoplasmic reticulum (PubMed:19706595). Expressed in brain, liver, spleen, skeletal muscle, heart, lung and kidney (PubMed:29910000). High expression is observed in the cerebellum, specifically in astrocytes (PubMed:29910000). Highly expressed in skeletal muscle (at protein level) (PubMed:19706595). Up-regulated during C2C12 myogenic differentiation. Knockout mice develop bilateral calcifications in the thalamus, due to the formation of calcium phosphate deposits. The requirement of the predicted catalytic residue Asp-462 to support myogenic function strongly suggests that MYORG is an enzymatically active glycosidase in vivo, even if concrete experimental proof for enzymatic activity is still missing. Belongs to the glycosyl hydrolase 31 family. Extended N-terminus.