Critical allergen and main toxic protein of C.quadrigatus venom (PubMed:26201970). Has potent hemolytic activity (PubMed:11866126). Is lethal to crayfish (PubMed:11866126). Causes cutaneous inflammation in humans (PubMed:26201970). May act as a pore-forming toxin, disrupting normal transmembrane ion concentration gradients in susceptible cells (By similarity). Heat-stable protein that continues to cause erythematous skin eruption in the patient and to recognize IgE after heating. Forms a membrane channel in the prey. Contains disulfide bonds. N-glycosylated. Causes an allergic reaction in human. Binds to IgE and IgG(4). LD(50) is 80 ug/kg by intraperitoneal injection into crayfish. Belongs to the jellyfish toxin family. Type I subfamily.