Functions as a redox-dependent negative regulator of the Wnt signaling pathway, possibly by preventing ubiquitination of DVL3 by the BCR(KLHL12) complex. May also function as a transcriptional regulator act as a regulator of protein phosphatase 2A (PP2A). [protein]-dithiol + NAD(+) = [protein]-disulfide + H(+) + NADH [protein]-dithiol + NADP(+) = [protein]-disulfide + H(+) + NADPH Associates with the phosphatase 2A holoenzyme. Interacts with PPP2CA; the interaction is direct. Interacts with DVL1 (via PDZ domain); the interaction is direct and regulated by oxidative stress. Widely expressed with higher expression in testis and skin. Specifically expressed form 9.5 dpc to 12.5 dpc in limb buds. Perinatal lethality, possibly due abnormal cardiovascular development. Osteoblasts show an aberrant activation of the Wnt signaling pathway. Belongs to the nucleoredoxin family.