ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (By similarity). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (PubMed:15814571, PubMed:16225954). an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ADP + H(+) + phosphate ATP + dehydroepiandrosterone 3-sulfate(in) + H2O = ADP + dehydroepiandrosterone 3-sulfate(out) + H(+) + phosphate ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out) ATP + glycocholate(in) + H2O = ADP + glycocholate(out) + H(+) + phosphate ATP + H2O + taurolithocholate 3-sulfate(in) = ADP + H(+) + phosphate + taurolithocholate 3-sulfate(out) ATP + H2O + taurochenodeoxycholate 3-sulfate(in) = ADP + H(+) + phosphate + taurochenodeoxycholate 3-sulfate(out) ATP + bilirubin-glucuronoside(in) + H2O = ADP + bilirubin-glucuronoside(out) + H(+) + phosphate ATP + bilirubin-bisglucuronoside(in) + H2O = ADP + bilirubin-bisglucuronoside(out) + H(+) + phosphate Detected throughout the gastrointestinal tract, liver, lung, pancreas, bladder, gall bladder and at low levels in the adrenal gland. Deficient mice do not exhibit any overt phenotype under normal conditions. However when challenged with cholestasis induced by bile duct ligation, increased levels of hepatic bile salts and lower serum levels of bilirubin glucuronide are observed, suggesting that Abcc3 provides an alternative route for removal from the liver of these substrates under cholestatic conditions. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.