Plays a role in cholinergic transmission and as a functional partner of dystrobrevin (dyb-1), necessary for muscle maintenance. Required for neuronal positioning. Component of the dystrophin glycoprotein complex (DGC). Interacts with dyb-1 and stn-1 to form the DGC. Interacts with stn-2. Expressed in body wall, head, pharyngeal and vulval muscles, from late embryogenesis to adulthood (at protein level). Mutants display a phenotype of hyperactive locomotion and are hypersensitive to the acetylcholinesterase inhibitor aldicarb and are defective in maintaining neuronal positioning. Dys-1 and hlh-1 double mutants synergistically exhibit progressive myopathy.