Effector protein that participates in the suppression of macrophage apoptosis by blocking the extrinsic pathway. Interferes with caspase-8 activation and binds to the host E3 ubiquitin-protein ligase RNF213, whose fusion partners have anti-apoptotic function. Interacts with human E3 ubiquitin-protein ligase RNF213. Is secreted into the macrophage cytoplasm. Might be secreted via a type IV pili apparatus that seems to be encoded in the same operon. Component of the Rv3654c-Rv3660c operon that is highly up-regulated during M.tuberculosis infection of macrophages.