Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II (By similarity). May participate in mRNA transport in the cytoplasm. Interacts with YES1, SRC, FYN. Upon tyrosine phosphorylation, interacts with PIK3R1 (By similarity). Interacts with PURA. Translocates to plasma membrane upon ultraviolet exposure. Present in Purkinje cells in the cerebellum, and in cortical neurons (at protein level). Expressed in the developing brain at 12 dpc. Expression increases postnatally and is maintained at an adult level beyond 4 weeks after birth. Arg-980 is dimethylated, probably to asymmetric dimethylarginine. Phosphorylated on tyrosine by src family kinases upon ultraviolet exposure. Belongs to the constitutive coactivator of PPAR-gamma family.