Orphan receptor that binds DNA as a monomer to hormone response elements (HRE) containing an extended core motif half-site sequence 5'-AAGGTCA-3' in which the 5' flanking nucleotides participate in determining receptor specificity. May be required to pattern anterior brain differentiation (By similarity). Involved in the regulation of retinal development. Monomer. Expressed exclusively in the neuroepithelium of the embryonic brain. Belongs to the nuclear hormone receptor family. NR2 subfamily.