ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. Homotetramer. Accumulates in roots during S starvation, but decreased after SO(4) anion restoration (at protein level). Repressed locally and systemically by phloem-translocated glutathione (GSH) (at protein level). Belongs to the sulfate adenylyltransferase family.