Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. internalized after activation by endothelins. Defects in EDNRB are a cause of overo lethal white syndrome (OLWS) also known as lethal white foal syndrome (LWFS). It is an inherited syndrome of foals born to American paint horse parents of the overo coat-pattern lineage. Affected foals are totally or almost totally white and die within days from complications due to intestinal aganglionosis. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.