Negatively regulates myogenesis and skeletal muscle regeneration via its association with ITGB1 (PubMed:34427057). Modulates ITGB1 activation by decreasing ITGB1-LAMB1 interaction and inhibiting ITGB1-mediated intracellular signaling during myogenesis (PubMed:34427057). Interacts with ITGB1. Highly expressed in white adipose tissues (WAT), with 10-fold to 20-fold higher levels than in brown adipose tissue (BAT). Also expressed in skeletal muscle, heart and lung. Lower relative levels of expression in kidney, spleen, testis, brain and liver. Up-regulated in adipogenesis and also markedly up-regulated during in vitro myogenesis of C2C12 myoblasts to myocytes. Up-regulated during myoblast differentiation. Mice exhibit significant increases in body weight, muscle mass, muscle fiber number, muscle fiber diameter and myotube formation and an acceleration of skeletal muscle regeneration. Belongs to the TMEM182 family.