Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (PubMed:14988505). May also play an important role in early urinary-tract development (PubMed:31051115). Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells. In a 7-week embryo, expressed in the urogenital sinus, the precursor of the bladder, and its outflow tract. The most prominent expression is in the primitive urothelium, and there is weaker expression in the surrounding mesenchyme. Expression also detected in the urothelium of the adult male urethra. The disease is caused by variants affecting the gene represented in this entry. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus.