Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Interacts with TRPC4AP (By similarity). Homotetramer and heterotetramer with TRPC4 and/or TRPC5 (PubMed:12032305). Interacts with TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (PubMed:10766822). Interacts with MX1 and RNF24 (PubMed:15757897, PubMed:17850865). Interacts with FKBP4 (PubMed:19945390). Interacts with PLSCR1 (By similarity). Interacts with isoform 2 of TRPC3. Seems to be ubiquitous. Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.