Nonessential SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. Component of two distinct SNARE complexes consisting of SED5, BOS1, BET1 and SEC22 or UFE1, USE1, SEC20 and SEC22. YKT6 can probably replace SEC22 as subunit of either complex. Interacts with SEC24, YIF1 and YIP1. Present with 396 molecules/cell in log phase SD medium. Deletion of SEC22 is viable. Overexpression of SEC22 suppresses deletion of YPT1. Belongs to the synaptobrevin family.