Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Interacts with ATP6AP2. Associated to membranes via binding to ATP6AP2. Kidney. Renal renin is synthesized by the juxtaglomerular cells of the kidney in response to decreased blood pressure and sodium concentration. In inbred mouse strains, there are at least two alleles which can occur at the Ren1 locus: Ren-1D and Ren-1C. The sequence shown is that of Ren-1C. Present as a single-copy gene in strains such as BALB/c and C57BL/6 while some strains such as Swiss and Akr contain two copies. Belongs to the peptidase A1 family.