Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity). Can complement the growth defect of a yeast mutant lacking REI1 (PubMed:24038679). Required for leaf growth under cold temperature conditions (PubMed:24038679). Can form homodimer. Interacts with RLP24, RLP24A, RPL24B, EBP1 and JJJ1. By cold. No visible phenotype under normal growth conditions. When grown at 10 degrees Celsius, the double mutant seedlings reil1-1 and reil2-1 show growth arrest at two cotyledon stage and die. Belongs to the REI1 family.