Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Interacts with CCDC100/CEP120 (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF. Experimental confirmation may be lacking for some isoforms. Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. Expressed in fetal brain, lung, liver and kidney. Phosphorylated by TTK; which is required for localization in centrosome. Belongs to the TACC family. Intron retention.