Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity). Catalyzes the hydrolysis of diadenosine tetra-, penta-, or hexa-phosphate with the departure of ATP as leaving group. Preferred substrate is Ap4A. Also acts on diguanosine tetra- and penta-phosphate at a lesser extent. Required with IalB for erythrocytes invasion. Binds 2 divalent metal ions. Zinc, magnesium or manganese. Monomer. Belongs to the Nudix hydrolase family. RppH subfamily.