Forms a homodimer or heterodimer with other members of the family. All isoforms interact with several 14-3-3 proteins. Isoform 2 is expressed in colon, breast, prostate, pancreas and kidney tumor cell lines. Isoform 2 is expressed at high levels in kidney, prostate, brain, small intestine and pancreas, at moderate levels in placenta and colon, at low levels in lung, liver and heart, and at very low levels in spleen, thymus, peripheral mononuclear blood cells, testis and ovary. Isoform 2 is expressed at lower levels in fetal brain and kidney than in adult brain and kidney. Interacts only with YWHAB and YWHAQ among 14-3-3 proteins. Belongs to the TPD52 family.