May have roles in cellular differentiation. Ectopic expression induces differentiation of fibroblast into myofibroblast and myofibroblast ameboid migration. Increases retinoic-acid regulation of lipid-droplet biogenesis. May also have neural functions. Promotes axonal regeneration and augments motility of gliomas. Down-regulates the expression of TGFB1 and TGFB2 but not of TGFB3. May play a role in the regulation of alveolar generation. Interacts with FLNA (By similarity). Interacts with the latency-associated peptides (LAP) of TGFB1 and TGFB2; the interaction results in a decrease in TGFB autoinduction. Expressed in brain and fetal lung. Expressed mainly in neurons belonging to a late migration wave. During adulthood, it persists at a high level in the granular layer of the cerebellum, the hippocampus and the olfactory bulb. In lung, detected at low levels at the pseudoglandular stage (14.5 dpc), with expression starting to increase at the beginning of distal lung development (16.5 dpc) and remaining at the same level during saccular development (18.5 dpc). The expression levels are highest at the beginning of and during alveolar development (P5-P14) before decreasing again to low levels at the end of alveolization (P30). Down-regulated in lungs by dexamethasone treatment. Phosphorylated on Ser-59. Phosphorylation decreases stability and activity. Normal heat and mechanical sensitivity, as well as normal formalin-induced inflammatory pain. Reduced formalin-induced avoidance behavior, which reflects pain-related negative emotion, indicating a role in the affective, but not in the sensory component of the pain. Also exhibits altered behavioral responses in learning and memory.