Negatively regulates axonal outgrowth and is essential for normal synaptic transmission (PubMed:32153366). Not required for regulation of axon polarity (PubMed:32153366). Promotes acetylation of alpha-tubulin (PubMed:32153366). Interacts with alpha-tubulin. Highly expressed in brain and spinal cord (at protein level) (PubMed:32153366). In brain, expression is detected in the main olfactory bulb, cortex, lateral ventricle, cornu ammonis 1, cornu ammonis 3, dentate gyrus, striatum, cerebellar cortex and medial habenula (PubMed:32153366). Expressed primarily in neurons including excitatory pyramidal neurons and inhibitory interneurons (PubMed:32153366). In the embryo, expression initiates at 15.5 dpc in both the neocortex and hippocampus. Excessive axonal outgrowth and branching with decreased dendritic outgrowth (PubMed:32153366). Reduced acetylation of alpha-tubulin (PubMed:32153366). Belongs to the DIP2 family.