Probable substrate recognition component of SCF (SKP1-CUL-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates synapse elimination in early development in the motor neuron HSNL (PubMed:17626846). Cell autonomous negative regulator of lin-12/Notch-mediated signaling, with respect to lin-12 activity in cell fate decisions and tumorigenesis (PubMed:9389650). May target the intracellular domains of lin-12/Notch proteins for ubiquitin-dependent degradation (PubMed:9389650). Involved in sex determination by promoting female development (PubMed:15306688, PubMed:18718460). Potential regulator of presenilin (PubMed:9861048). May have a role in egg laying (PubMed:8293978, PubMed:15306688). Regulates zyg-1 levels (possibly redundantly with lin-23) to control centrosome duplication during mitosis (PubMed:22623721). Negatively regulates lin-45 activity and protein stability, probably by targeting it for ubiquitination and proteasomal degradation (PubMed:23154983). Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex which includes skr-1 and F-box domain-containing protein sel-10 as a substrate recognition component (PubMed:17626846). Interacts with fem-1, fem-2, and fem-3 (PubMed:15306688). Interacts with the intracellular domain of glp-1 and sel-12 (PubMed:9861048). Interacts with lin-12 (PubMed:9389650). Interacts with skr-1 (PubMed:18718460). Interacts with zyg-1 (PubMed:22623721). Expressed throughout the axon throughout development. Expressed in tail and head neurons. Expression begins at the 50-cell embryonic stage and continues throughout development (PubMed:19528325). Expressed in the HSNL motor neuron from early larval stage L4 to the young adult stage (PubMed:17626846). Worms show a weak masculinization phenotype (PubMed:8293978). Moreover sel-10 mutants suppress the egg laying defective (egl) phenotype of the sel-12 mutants (PubMed:8293978). RNAi-mediated knockdown results in increased zyg-1 expression at centrosomes (PubMed:22623721).