Effector that enhances P.infestans colonization of Nicotiana benthamiana leaves, which suggests that PITG_22798 contributes to P.infestans infection (PubMed:28216607). Triggers cell death in Nicotiana benthamiana. PITG_22798-triggered cell death is dependent on SGT1-mediated signaling but not HSP90, and is suppressed by the P.infestans avirulence effector 3b (AVR3b) (PubMed:28216607). Lovalization to host nucleus is require to induce cell death. Expression is induced early during infection of P.infestans. The nuclear localization signal is required for the localization into the host nucleus and the ability to induce host cell death. The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate. Belongs to the RxLR effector family.