Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules (By similarity). Interacts with microtubules. Interacts with YEATS4, GCN5L2 and PCAF (By similarity). Interacts with CCDC100/CEP120. Expressed in brain, kidney, lung, thymus and ovary. Not detectable in normal tissues at protein level. Phosphorylated; which is required for localization in centrosome. Mice develop normally, are fertile, and do not present elevated tumorization rates. Cells deficient in TACC2 divide normally and do not show any change in the frequency of apoptosis induction. Belongs to the TACC family.