Lanthionine-containing peptide antibiotic (lantibiotic) active on Gram-positive bacteria. The bactericidal activity of lantibiotics is based on depolarization of energized bacterial cytoplasmic membranes, initiated by the formation of aqueous transmembrane pores. Maturation of lantibiotics involves the enzymatic conversion of Thr, and Ser into dehydrated AA and the formation of thioether bonds with cysteine. This is followed by membrane translocation and cleavage of the modified precursor. The structure of the 2,3-didehydrobutyrine is not discussed in PubMed:8454055. However, in Fig. 1 the residue is diagrammed as the Z-isomer. Used as a food preservative. In strain 6F3 the nisA gene is encoded on an unnamed plasmid. The reported protein sequences are identical. Belongs to the type A lantibiotic family.