Fungal ribonuclease involved in fungal defense. Highly specific and highly toxic fungal endonuclease that cleaves a single phosphodiester bond in the 28S RNA of eukaryotic ribosomes at a universally conserved GAGA tetraloop of the sarcin-ricin loop (SRL). The damage of the SRL inhibits the binding of translation elongation factors and halts protein biosynthesis, ultimately resulting in the death of the target cells (PubMed:31444206, PubMed:28232091, PubMed:30262416). Shows antitumor activity (PubMed:28232091, PubMed:30262416). Exerts cytotoxicity and induces apoptosis towards rat glial cells and human glioma cells, and also displays some activity towards human neurolastoma cell lines (PubMed:28232091). Shows a strong entomotoxicity against Aedes aegypti larvae, yet no nematotoxicity against nematodes (PubMed:31444206). a 28S rRNA containing guanosine-adenosine pair + H2O = an [RNA fragment]-3'-adenosine-3'-phosphate + a 5'-a hydroxy-guanosine-3'-[RNA fragment]. In contrast to most ribotoxins, activity is completely inhibited by EDTA. Highly thermostable. Has a melting temperature of 78 degrees Celsius at pH 7.4. Monomer. Possibly sequestered into the vacuole to avoid its toxic activity on ribosomes. Highly Expressed during fruiting body formation. The strong larvicidal activity of ageritin makes this protein a promising candidate for novel biopesticide development. Belongs to the ribotoxin-like family.