Involved in the regulation of cell cycle progression, this activity is related to the inhibition of apoptosis following the removal of essential growth factors (PubMed:12145692). Exhibits H3K4me3-binding activity (PubMed:29061846). Interacts with C11orf84/SPINDOC (PubMed:29061846). Detected in all the examined tissues with highest expression in liver, followed by heart, stomach, kidney, skeletal muscle, placenta, and pancreas. Overexpression in murine myeloid cell line 32Dcl3 causes G2/M arrest. Belongs to the SPIN/STSY family.