Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. May inhibit NF-kappa-B transcription, and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1-dependent manner). Has a negative regulation effect on G1 to S transition of mitotic cell cycle. Involved in growth regulation. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine Self-associates (By similarity). Interacts with HNRNPUL1. Interacts with NFKBIA (By similarity). Interacts with NCOA6 coactivator. Interacts (via SH3 domain) with PRMT8. Interacts with AR. Interacts with ESR1, ESR2, PGR, PPARG, RARA, RXRA and THRB (By similarity). Interacts with RB1 and E2F1. Translocates from the cytoplasm to the nucleus, after hormone exposure. Expressed in liver, pancreas, lung, brain, skeletal muscle, heart, muscle and fat. From 6 to 30 weeks of age, males gain less weight than age-matched control wild-type mice when weaned onto a chow diet. By 30 weeks of age, females are also lean compared with wild-type females. At 12 weeks of age, male and female are 3% to 4% shorter than wild-type controls. Shows less hepatic cytoplasmic vacuoles, more distinct hepatic cords and sinusoids and increased leptin sensitivity. Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.