Binds calmodulin in a calcium dependent manner. May function as scaffolding or signaling protein. Interacts with protein phosphatase 2A (PP2A) (Potential). Interacts with CTTNBP2; this interaction may regulate dendritic spine distribution of STRN. Activation of glutamate receptors weakens the interaction with CTTNBP2. CTTNBP2-binding may regulate dendritic spine distribution. Mainly expressed in the central nervous system. Mostly confined in dendrites, not in axons, and is most abundant in dendritic spines. Belongs to the WD repeat striatin family.