Mediates cell-cell adhesion in a calcium-dependent manner. Able to inhibit growth in several cell lines. Expressed predominantly in whole brain and kidney, with limited expression in heart, lung, liver, and skeletal muscle and no expression in spleen and testis. Also expressed in pituitary gland, adrenal gland, digestive tract, and reproductive organs. By p53. Both EF-hands are required for function. Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.