Hydrolyzes N,N-dimethylformamide, and to a lesser extent N,N-dimethylacetamide and N,N-diethylacetamide. Has no activity against the substituted amides N-methylformamide, N-ethylformamide, N-ethylformamide and N-methylacetamide or the unsubstituted amides formamide, nicotinamide, acetoamide, benzamide, acetamide and acrylamide (By similarity). H2O + N,N-dimethylformamide = dimethylamine + formate Heterotetramer of two DmfA1 (alpha) and two DmfA2 (beta) subunits. By N,N-dimethylformamide. It is not known which subunit of DmfA1 or DmfA2 possesses catalytic activity.