Effector that promotes P.infestans virulence and suppresses pattern-triggered immunity (PTI) (PubMed:26966171, PubMed:30049706). Interacts with the host ubiquitin E3 ligase NRL1 and enhances the association between NRL1 and SWAP70 to promote proteasome-mediated degradation of SWAP70, which results in the suppression of immunity (PubMed:26966171, PubMed:30049706). Interacts with host ubiquitin E3 ligase NRL1. The cytoplasmic localization is more important for its contribution to virulence than the nucleoplasmic localization. The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate. The C-terminus (residues 126 to 135) is required for the interaction with host NRL1 and the ability to enhance the association of NRL1 with SWAP70. Belongs to the RxLR effector family.