Cell surface proteoglycan that bears heparan sulfate. Modulates Wnt-signaling pathway. Expressed at stage 7 of embryonic development in the folding anterior part of the neural plate. At stage 8, high levels in all four newly formed epithelial somites and in the rostra1 paraxial mesoderm. Expressed also in the cephlic region of the developing neural fold. Later expression in the entire limb bud, including mesenchyme and ectoderm. In the developing brain, first detected at stage 7 in the anterior portion of the neural folds that are destined to give rise to the telencephalon. Later in development (stage 25), glypican transcripts were found in postmitotic cells in the mantle zone. Expressed by ectodermal and ingressing chick trigeminal placode cells at the time they differentiate into neurons and assemble into ganglia. Also expressed in the migrating hindbrain neural crest cells from rhombomeres 4 and 6 during migration at stage 12. O-glycosylated with heparan sulfate. Belongs to the glypican family. Truncated N-terminus.