Nuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1/ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Lacks ligand binding affinity and suppresses ESR1/ER-alpha and ESR2 isoform 1/ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action. Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA1, NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes. Interacts with PRMT2. Interacts with CCAR2 (via N-terminus) in a ligand-independent manner (By similarity). Interacts with DNAAF4. Interacts with RBM39, in the presence of estradiol (E2) (By similarity). Additional isoforms seem to exist. Expressed in prostate, ovary, lung, liver, kidney, fat, bone, brain, uterus and testis. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Phosphorylation at Ser-87 and Ser-105 recruits NCOA1. Belongs to the nuclear hormone receptor family. NR3 subfamily. Truncated N-terminus.