Orphan receptor that may have a role in planar cell polarity pathway. Interacts (via PDZ-binding motif) with DLG1. Expressed by spermatogonial progenitor cells located within the outer cell layer of the seminiferous tubule and by multipotent adult spermatogonial-derived stem cells. Most adhesion GPCRs proteins undergo autoproteolysis at the GPS domain. ADGRA3 is predicted non-cleavable because of the lack of a consensus catalytic triad sequence within GPS domain. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Extended N-terminus.