Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This toxin blocks neuronal mammalian alpha-7 (human and rat) and alpha-3/beta-2 (human) and muscle alpha-1-beta-1-delta-epsilon (human) nAChRs (PubMed:12384509, PubMed:15609996). Acts voltage-independently (PubMed:12384509). Does not competes with alpha-bungarotoxin for binding to the receptor (PubMed:12384509, PubMed:15609996). Binds to a different site than alpha-conotoxin ImI (PubMed:15609996). Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/3 pattern. Does not inhibit alpha-2-beta-2, alpha-2-beta-4, alpha-3-beta-4, alpha-4-beta-2, alpha-4-beta-2 nAChRs. Belongs to the conotoxin A superfamily.