Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as itraconazole, posaconazole, and voriconazole. ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out) The efflux inhibitor FK506 impairs the transport activity. Expression is induced upon voriconazole treatment (PubMed:24123268). Expression is also induced in triazole-resistant isolates (PubMed:32209680). Leads to decreased azole resistance, including itraconazole, posaconazole and voriconazole. Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.