Acaloleptins A1-A4 show antibacterial activity against Gram-negative bacteria but not against Gram-positive bacteria. Acaloleptin A5 shows antibacterial activity against Gram-positive bacteria but not against Gram-negative bacteria, and may also have antifungal activity. Hemolymph (at protein level). Larval fat body. By bacterial infection. Expression detected 2 hours post-injection, with expression increasing until 48 hours post-injection and remaining considerably high at least until 72 hours post-injection. Belongs to the coleoptericin family.