May influence large dense-core vesicle exocytosis in adrenal chromaffin cells. Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:26342074). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (By similarity). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (By similarity). Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:24603049, PubMed:26342074, PubMed:28972156). Facilitates endosomal acidification and chloride accumulation in hepatocytes (PubMed:15504734). Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. Inhibited by Cd(2+). Inhibited by Cd(2+). Monomer and homodimer (PubMed:28972156). Forms heterodimers with CLCN4 (PubMed:28972156). Detected in kidney, in the apical part of proximal tubule cells (at protein level). Expressed at high levels in the kidney while a low level expression is seen in the brain. Within the brain, it is prominent in the hippocampus, cerebral cortex and olfactory bulb. Brain, pancreas, kidney, liver, lung, retina, olfactory bulb, and spinal cord. Brain, pancreas, kidney, liver, lung, retina, olfactory bulb, and spinal cord. Pancreas, kidney, liver, lung and retina. Brain, heart, pancreas, kidney, liver, lung, retina, olfactory bulb, and spinal cord. Expressed at high levels in the liver and at low levels in the brain. At 10.5 days of development it is expressed throughout the embryo. Later in development (12.5 to 14.5 days of gestation), expression is progressively up-regulated in neurons of the brain and the spinal cord, in all cranial sensory ganglia and in the sympathetic dorsal root ganglia. N-glycosylated. Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.