Tuberculosinyl transferase that catalyzes the condensation of adenosine and tuberculosinyl diphosphate (TbPP) to generate 1-tuberculosinyladenosine (1-TbAd), which acts as an antiacid that directly protects M.tuberculosis from acid pH and physically remodels M.tuberculosis phagolysosomes (PubMed:24516143, PubMed:31427817). In addition, acts as a phosphatase that catalyzes the diphosphate-removal from TbPP to produce both tuberculosinol (TOH) and isotuberculosinol (iso-TOH) (PubMed:21228491, PubMed:24475925). Has broad substrate specificity, and can also use the 3 labdadienyl diphosphates, copalyl diphosphate (CDP), ent-CDP and syn-CDP in vitro (PubMed:21290071). adenosine + H(+) + tuberculosinyl diphosphate = 1-tuberculosinyladenosine + diphosphate H2O + tuberculosinyl diphosphate = diphosphate + tuberculosinol H2O + tuberculosinyl diphosphate = (13R)-edaxadiene + diphosphate H2O + tuberculosinyl diphosphate = (13S)-edaxadiene + diphosphate (+)-copalyl diphosphate + H2O = (+)-copalol + diphosphate (+)-copalyl diphosphate + H2O = diphosphate + manool (+)-copalyl diphosphate + H2O = 13-epi-manool + diphosphate ent-copalyl diphosphate + H2O = (-)-ent-copalol + diphosphate ent-copalyl diphosphate + H2O = diphosphate + ent-manool 9alpha-copalyl diphosphate + H2O = diphosphate + syn-copalol 9alpha-copalyl diphosphate + H2O = (13S)-vitexifolin A + diphosphate Can also use Fe(2+), Cu(2+), Mn(2+), Zn(2+) and Ni(2+). Inhibited by the bisphosphonate inhibitor BPH-629. kcat is 0.031 min(-1) with tuberculosinyl diphosphate as substrate. Optimum pH is 7. It is active in a pH range of 5.5-9.0. Optimum temperature is 45 degrees Celsius. No activity is detected above 50 degrees Celsius. Homodimer. Deletion of the gene abolishes 1-TbAd biosynthesis and decreases the formation of swollen phagosomes. 1-TbAd is highly prevalent among patient-derived M.tuberculosis strains, where it is among the most abundant lipids produced. Belongs to the diterpene synthase family.