Serine/threonine protein kinase that plays a role in viral gene expression, viral DNA replication and encapsidation, and nuclear egress of virions. Regulates host transcriptional activity through interactions with RNA helicase and c-Jun N-terminal kinase (JNK) and viral transcriptional activity through interactions with the viral protein K-bZIP/K8 (PubMed:17108053). Induces host chromosome condensation and phosphorylation of histone H3. Phosphorylates the DNA polymerase processivity factor hence modulating its processivity function. Inhibits the host Wnt signaling pathway via direct interactions with beta-catenin/CTNNB1 while the kinase activity of vPK is not required for this inhibitory activity. Phosphorylates also host SAMHD1 and thereby counteracts its antiviral effect by reducing its dNTP hydrolase activity. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Interacts with protein K-bZIP/K8 (PubMed:17108053). Interacts with host beta-catenin/CTNNB1 (PubMed:29432739). AUtophosphorylated.