Involved in L-phenylalanine-derived cyanogenic glycoside biosynthesis, including prunasin and amygdalin defensive agents (PubMed:25015725). Catalyzes the conversion of phenylacetaldoxime (PAOx) and phenylacetonitrile (PAN) into mandelonitrile (MAN) (PubMed:25015725). To a lower extent, can convert various aromatic aldoximes and nitriles; mediates the transformation of 4-hydroxyphenylacetaldoxime, 4-hydroxyphenylacetonitrile, indole-3-acetal-doxime and indole-3-acetonitrile into the corresponding hydroxynitriles, but cannot use the aliphatic compounds 2-methylpropanaloxime and 2-methylpropanenitrile as substrates (PubMed:25015725). (E)-phenylacetaldehyde oxime + O2 + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] O2 + phenylacetonitrile + reduced [NADPH--hemoprotein reductase] = (R)-mandelonitrile + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] kcat is 46.3 min(-1) with phenylacetaldoxime as substrate (in the presence of NADPH at pH 7.6 and 30 degrees Celsius) (PubMed:25015725). kcat is 24.2 min(-1) with phenylacetonitrile as substrate (in the presence of NADPH at pH 7.6 and 30 degrees Celsius) (PubMed:25015725). kcat is 37 min(-1) with 4-hydroxyphenylacetaldoxime as substrate (in the presence of NADPH at pH 7.6 and 30 degrees Celsius) (PubMed:25015725). kcat is 34 min(-1) with 4-hydroxyphenylacetonitrile as substrate (in the presence of NADPH at pH 7.6 and 30 degrees Celsius) (PubMed:25015725). kcat is 1.7 min(-1) with indole-3-acetaldoxime as substrate (in the presence of NADPH at pH 7.6 and 30 degrees Celsius) (PubMed:25015725). kcat is 6.1 min(-1) with indole-3-acetonitrile as substrate (in the presence of NADPH at pH 7.6 and 30 degrees Celsius) (PubMed:25015725). Expressed in seedlings and leaves. Belongs to the cytochrome P450 family.