Its interaction with PHYH suggests a role in the development of the central system. Interacts with PHYH and ADGRB1. Highly expressed in the brain. At 18 dpc, expressed in most tissues, particularly in the skin. By neonatal day 1, the expression in brain and skin is markedly increased, whereas expression in the heart and skeletal muscles shows steady state levels similar to those observed in the fetus. At adulthood, very high expression in brain, little or no expression in other tissues. Overexpression in heart induce atrial tachycardia and increased susceptibility to aconitine-induced arrhythmia, possibly due to altered expression of voltage-gated K(1+) channel and adrenergic beta1-receptor (ADRB1). Belongs to the PHYHIP family.