Protein kinase with a significantly reduced Ca(2+)+/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Interacts with MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK9/JNK2, PPP1R9B/NEURABIN-2 and actin (By similarity). Binds to and stabilizes microtubules; binding affinity is strongly reduced by autophosphorylation. Colocalizes with microtubules. When overexpressed in sympathetic neurons, localizes to cell body and to the terminal segments of axons and dendrites. The doublecortin domains are involved in the binding to microtubules. Autophosphorylated. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily.