The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Interacts with ARRB1 and ARRB2 (By similarity). Interacts with RACK1; the interaction regulates CHRM2 internalization. Phosphorylation in response to agonist binding promotes receptor internalization. Phosphorylated in response to agonist treatment. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.