Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). Multimeric. Interacts with F8 (By similarity). Localized to storage granules. Plasma. The propeptide is required for multimerization of vWF and for its targeting to storage granules. All cysteine residues are involved in intrachain or interchain disulfide bonds. N- and O-glycosylated.