AS-C proteins are involved in the determination of the neuronal precursors in the peripheral nervous system and the central nervous system. Efficient DNA binding requires dimerization with another bHLH protein. Interacts with SETD1A. Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity. Expressed specifically in the extravillous trophoblasts of the developing placenta.