Regulator of different signaling pathways. Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction. Interacts (via SAM domain) with EPHA2 (via SAM domain) (By similarity). Interacts with EPHA8; EPHA8 kinase activity-independent but stimulated by EPHA8 ubiquitination (PubMed:17875921). Interacts (via SAM domain) with EPHA6 (via SAM domain) (PubMed:29749928). Cytoplasmic before and after growth factor treatment. Phosphorylated on tyrosine residues in response to EGF and PDGF.