Single-chain ribosome-inactivating protein. Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. Monomer. Expressed in leaves (at protein level). Causes an allergic reaction in human. Natural protein was found to bind to IgE of three patients who had been working with ribosome-inactivating proteins for two to three years in a research laboratory setting. Possesses high antiviral potency, but relatively high toxicity to normal cells in culture and to intact animals. Capable of inhibiting HIV-1 infection and replication (PubMed:1936243). Allergy may occur upon exposure to this protein, which needs to be taken into account when considering it for therapeutic purposes (PubMed:16238796). Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.