Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of sesterfisheric acid (PubMed:26332841). The bifunctional terpene synthase NfSS converts DMAPP and IPP, and also GGPP, into sesterfisherol (PubMed:26332841, PubMed:29410538). The C-terminal prenyltransferase (PT) domain of NfSS catalyzes formation of GFPP, whereas the N-terminal terpene cyclase (TC) domain catalyzes the cyclization of GFPP to sesterfisherol (PubMed:26332841, PubMed:29410538). The cyotochrome P450 monooxygenase NfP450 then catalyzes oxidative modifications of sesterfisherol into sesterfisheric acid (PubMed:26332841). Secondary metabolite biosynthesis; terpenoid biosynthesis. Belongs to the cytochrome P450 family.