May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules. Acts also as an inflammation-resolving regulator by interacting with both TRIM25 and RIG-I/DDX58, subsequently impairing DDX58 'Lys-63'-linked polyubiquitination leading to IRF3 and NF-kappa-B inhibition. Homodimer. Interacts with RTN4. Interacts with BACE1, BACE2, BCL2 and FADD. Interacts with ATL1 and ATL2. Interacts with TMEM33. Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner. Interacts with DDX58. Interacts with TRIM25.