Proteolytically removes the C-terminal three residues of farnesylated proteins. Acts on lamin A/C. The peptide bond hydrolyzed can be designated -C-|-A-A-X in which C is an S-isoprenylated cysteine residue, A is usually aliphatic and X is the C-terminal residue of the substrate protein, and may be any of several amino acids. Binds 1 zinc ion per subunit. The metalloprotease domain is constituted by the two C-terminal nuclear regions. Belongs to the peptidase M48A family.