Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation (PubMed:2649253, PubMed:2645527, PubMed:2211693). Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells (PubMed:2649253, PubMed:2645527, PubMed:2211693). Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell (PubMed:2649253, PubMed:2645527, PubMed:2211693). D-glucose(out) = D-glucose(in) Binds to DAXX. Interacts via its N-terminus with SRFBP1 (By similarity). Interacts with NDUFA9 (PubMed:16396496). Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (By similarity). Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (By similarity). The dileucine internalization motif is critical for intracellular sequestration (By similarity). Insulin stimulation induces translocation to the cell membrane (PubMed:2211693). Expressed in skeletal and cardiac muscles (PubMed:2649883). Expressed in brown and white adipose tissues (PubMed:2649883). The dileucine internalization motif is critical for intracellular sequestration. Sumoylated. Palmitoylated. Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane. It is a candidate for certain post-receptor defects in non-insulin-dependent diabetes mellitus. Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation. Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.