Cell surface protein involved in the ability to sense and respond to changes in the host environment. Required for stress response and confers partial antifungal drug resistance. Contributes to the DNA damage response. Required for the flocculation response stimulated by 3-aminotriazole-induced amino acid starvation. Expression is induced during filamentation, biofilm formation, after UV exposure, as well as by benomyl, caspofungin, and ketoconazole. Also enriched in azole-resistant strains and in stationary phase. Expression is repressed by SKO1, HOG1, RFX2, farnesol, and in alkaline conditions. Expression is also controlled by the filamentous growth regulators CPH1, CPH2, and EFG1. leads to reduced flocculation stimulated by 3-aminotriazole-induced amino acid starvation. Belongs to the DDR48 family.