Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. Preferential cleavage: Leu-|-Xaa, Met-|-Xaa and Phe-|-Xaa. Hydrolyzes elastin. Interacts with CPA1. Interacts with SERPINA1. Highly expressed in pancreas (at mRNA and protein levels). Also expressed in adrenal gland and small intestine. Belongs to the peptidase S1 family. Elastase subfamily.