Secreted effector that promotes P.infestans colonization of plant host (PubMed:30329083, PubMed:31217198). Specifically suppresses Avr4/Cf4- and AvrPto/Pto-triggered cell death (PubMed:31217198). Targets the potato MAP3Kbeta2 kinase, a positive regulator of cell death associated with plant immunity, and perturbs signaling pathways triggered by MAP3Kbeta2 (PubMed:31217198). Interacts with host MAP3Kbeta2 in the nucleoplasm. Is secreted from haustoria to be delivered into host cells. Expression is up-regulated during the early plant infection stages. The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate. Belongs to the RxLR effector family.