Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of cordypyrones A and B, 2 pyrones that show modest activities against pathogenic bacteria including methicillin-resistant Staphylococcus aureus (MRSA), Mycobacterium tuberculosis and Bacillus cereus (PubMed:34548637). The HR-PKS milA catalyzes the formation of cordypyrones A via condensation of one acetate with 10 malonate units (PubMed:34548637). Since milA lacks an enoyl reductase domain, the 2 beta-keto processing domains DH and KR of milA collaborate with the trans-enoyl reductase milB to catalyze the different levels of reduction (PubMed:34548637). The cytochrome P450 monooxygenase milC then hydroxylates the C-22 of cordypyrones A to yield cordypyrones B (PubMed:34548637). cordypyrone A + O2 + reduced [NADPH--hemoprotein reductase] = cordypyrone B + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Secondary metabolite biosynthesis. Belongs to the cytochrome P450 family.