pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward. Homodimer (Probable). Heterodimer with KCNK1. Widespread expression in adult. Strongest expression in pancreas and placenta. Lower expression in brain, lung, prostate, heart, kidney, uterus, small intestine and colon. The disease is caused by variants affecting the gene represented in this entry. Inhibited by external acidification. Activated by halothane and isoflurane. Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.