Guanylate cyclase involved in the production of the second messenger cGMP (PubMed:9188508). Regulates olfactory perception in AWC sensory neurons although may not be involved in the primary sensory transduction steps (PubMed:18817734). Isoforms c: Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922). Regulates sensory integration of conflicting sensory cues in AIA interneurons (PubMed:21414922). GTP = 3',5'-cyclic GMP + diphosphate Excluded from the neuronal sensory cilia. Enriched in the axon of AWC sensory neurons. Is excluded from the neuronal sensory cilia. Expressed in head neurons, ventral cord and tail neurons, body wall muscle, hypodermis, somatic gonad and intestine (PubMed:16547101). Isoform d is expressed specifically in AIA interneurons (PubMed:21414922). The protein kinase domain is predicted to be catalytically inactive. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.