Exports glutathione-coordinated iron-sulfur clusters such as [2Fe-2S]-(GS)4 cluster from the mitochondria to the cytosol in an ATP-dependent manner allowing the assembly of the cytosolic iron-sulfur (Fe/S) cluster-containing proteins and participates in iron homeostasis (PubMed:16424901, PubMed:16467350). Moreover, through a functional complex formed of ABCB7, FECH and ABCB10, also plays a role in the cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). In cardiomyocytes, regulates cellular iron homeostasis and cellular reactive oxygen species (ROS) levels through its interaction with COX4I1 (By similarity). May also play a role in hematopoiesis (PubMed:17192398). (glutathione)4[2Fe(III)-2S] cluster(in) + ATP + H2O = (glutathione)4[2Fe(III)-2S] cluster(out) + ADP + H(+) + phosphate Homodimer or heterodimer. Interacts with C10orf88/PAAT (By similarity). Forms a complex with ABCB10 and FECH, where a dimeric FECH bridges ABCB7 and ABCB10 homodimers; this complex may be required for cellular iron homeostasis, mitochondrial function and heme biosynthesis (PubMed:30765471). Interacts with FECH (PubMed:30765471). Interacts with ATP5F1A. Interacts with COX4I1; this interaction allows the regulation of cellular iron homeostasis and cellular reactive oxygen species (ROS) levels in cardiomyocytes (By similarity). Heterozygous females for Abcb7 with a maternally inherited mutant allele die embryonically, due to a defect in the extra-embryonic visceral endoderm, while heterozygous females with a paternally inherited mutant allele are viable (PubMed:16467350). The systemic and tissue-specific deletion of ABCB7 in most organs, including CNS and bone marrow, is lethal (PubMed:16467350). Conditionnal knockout in hepatocyte causes periportal hepatocellular iron deposition with characteristic round structures and leads to iron-dependent regulation of IRP1 protein (PubMed:16467350, PubMed:16424901). Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.