Functions as an olfactory receptor activated by urine odorants, uroguanylin and guanylin and as well by the volatile semiochemicals carbon disulfide (CS2) and carbon dioxide (CO2) (PubMed:17724338, PubMed:17702944, PubMed:20637621). Has guanylate cyclase activity upon binding of the ligand (By similarity). Activation of GUCY2D neurons leads to the cGMP-dependent activation of the CNGA3 channels, membrane depolarization and an increase in action potential frequency (PubMed:17724338, PubMed:20637621). Signaling pathways activated by GUCY2D may trigger social behaviors such as acquisition of food preference (PubMed:20637621). GTP = 3',5'-cyclic GMP + diphosphate Activated by Ca(2+). Interacts (via the catalytic domain) with NCALD. Found in a subset of olfactory neurons in the main olfactory epithelium. The protein kinase domain is predicted to be catalytically inactive. Deficient mice lack olfactory response to uroguanylin and guanylin. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. The gene names for receptor guanylyl cyclases are inconsistent between mouse and human. The ortholog of the mouse Gucy2d gene is a pseudogene in humans. The mouse Gucy2d is not an ortholog of the human GUCY2D gene, the latter of which encodes a retinal receptor guanylyl cyclase involved in phototransduction.