Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin seems to specifically act on Nav1.6/SCN8A sodium channel (PubMed:31668811). In vitro, is active on DU145 prostate cancer cells proliferation (IC(50)=15 uM). It shows low effect on the adhesion of DU145 cells to fibronectin (at 15 uM) and is inactive on DU145 cells migration (PubMed:31668811). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). LD(50) is 0.9 ug/kg by intracerebroventricular injection into mice. LD(50) is 0.75 ug/kg by intracerebroventricular injection into mice. Does not show activity on Nav1.2/SCN2A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.7/SCN9A, Nav1.8/SCN10A (when tested at 5 uM). Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Alpha subfamily.