Transcriptional repressor which binds to the consensus sequence 5'-GCTCGC-3', transcription regulation may be tissue-specific (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799). Regulates the expression of target genes such as: IGF2, PGAP6/TMEM8, ENHO, and PIANP (PubMed:20016685, PubMed:20134481, PubMed:24043816, PubMed:29440408, PubMed:32557799). Acts as a transcriptional repressor of growth factor IGF2, thereby negatively regulating postnatal growth of muscles and internal organs, especially in females (PubMed:20016685, PubMed:29440408, PubMed:32557799). Negatively regulates myoblast differentiation and myoblast mitochondrial activity via its regulation of IGF2 transcription (PubMed:32557799). Negatively regulates the cell cycle of myoblasts, potentially via transcriptional regulation of the E2F family of transcription factors such as: E2F1 and E2F2 (PubMed:20016685, PubMed:32557799). Positively regulates the cell cycle and survival of pancreatic beta cells (PubMed:24043816). Binds to the CDH2 gene and may directly repress CDH2 transcription (PubMed:26750727). Probably by controlling CDH2 expression, regulates pancreatic beta cell adhesion, and formation of cell-to-cell junctions between pancreatic beta cells and neural crest stem cells (PubMed:26750727). May also play a role in embryonic beta cell differentiation (PubMed:24043816). May play a role in insulin sensitivity and glucose clearance (PubMed:29440408). Located predominantly in the nucleolus but is also dispersed throughout the nucleus (PubMed:20016685). Mainly cytoplasmic in insulin- and glucagon-positive islet pancreatic cells, however nuclear localization is evidence in some pancreatic endocrine cells (PubMed:24043816). Expressed in pancreatic islet cells and weakly expressed in surrounding exocrine tissues (at protein level) (PubMed:24043816). Expressed in muscle and brain (at protein level) (PubMed:20016685). Shows broad tissue distribution with expression detected in brain, stomach, intestine, heart, kidney, liver, lung, skeletal muscle, ovary, spleen, tail and testis (PubMed:20016685). Expressed in fetal muscle tissues at 12.5 dpc. Increase in body weight of mice at 20 weeks of age, at 23 weeks of age only female mice show an increase in body weight and lean mass as a result of an increase in muscle mass (PubMed:29440408). Increase in the weight of kidneys in both male and female adult mice with an increase in the weight of the liver in female mice (PubMed:29440408). Decrease in plasma insulin levels with an increase in blood glucose clearance and increased reliance on carbohydrates as a fuel source in male mice (PubMed:29440408). Increase in serum IGF2 protein levels in adult mice (PubMed:29440408). Increase in expression of IGF2, PGAP6/TMEM8, and ENHO in skeletal muscle (PubMed:29440408). Expression of ENHO and PIANP also increases in the heart and kidney, in addition to an increase of PGAP6/TMEM8 expression in the heart (PubMed:29440408). Significant increase in expression of PGAP6/TMEM8 and ENHO in fetal muscle tissue with a small marginal increase in IGF2 expression (PubMed:29440408). Encoded by an exapted DNA transposon located in an intron of the Zc3h11a gene. Truncated N-terminus.