DNA-binding transcriptional activator that interacts with calcineurin-dependent response element (CDRE) promoters (PubMed:28376087). Activates expression of genes required to maintain cell wall integrity during stress (PubMed:23251520, PubMed:28376087). Activates expression of genes required for transepithelial migration through the host blood-brain barrier (PubMed:29113016). Required for adaptation to host temperature during infection (PubMed:28376087). Localizes to the nucleus during calcium signaling, cell wall and heat stress (PubMed:21487010, PubMed:23251520, PubMed:24520056, PubMed:27611567, PubMed:28376087, PubMed:28898238, PubMed:31266771). Localizes to the nucleus following dephosphorylation by CNA1 (calcineurin) (PubMed:27611567). Localizes to the nucleus during growth on glucosamine carbon source (PubMed:28898238). Localizes to the cytosol during vegetative growth and osmotic stress (PubMed:23251520, PubMed:28376087, PubMed:28898238). Induced during glucose starvation. Phosphorylated (PubMed:21487010, PubMed:27611567). Dephosphorylated by calcineurin (CNA1) which promotes nuclear localization (PubMed:27611567). Decreases virulence in a mouse intranasal inhalation model and intravenous model for infection (PubMed:21487010, PubMed:27611567, PubMed:28376087, PubMed:29233914). Decreases virulence in a moth model (PubMed:28376087). Decreases urease activity (PubMed:29113016). Decreases levels of: laccase and melanin (PubMed:21487010). Hypercapsular with mucoid colony morphology (PubMed:21487010). Sensitive to: calcium; lithium; sodium nitrite; high temperature; sodium dodecyl sulfate (cell wall stress inducer); Calcofluor White (cell wall stress inducer); Congo Red (cell wall stress inducer); caspofungin (cell wall stress inducer) (PubMed:21487010, PubMed:27611567, PubMed:28376087, PubMed:29233914, PubMed:31266771). Abolishes filamentation during growth on glucosamine carbon source (PubMed:28898238). Decreases RNA level of genes involved in membrane transport, carbohydrate metabolism, signaling, DNA replication, and sterol biosynthesis during heat stress (PubMed:28376087). Decreases CHS5 and CHS6 RNA level during heat stress (PubMed:27611567, PubMed:28376087). Decreases RNA level of ZNF2 during growth on glucosamine carbon source (PubMed:28898238). Increases MFalpha1 expression during mating (PubMed:27611567). Normal hyphal morphology during mating (PubMed:23251520, PubMed:28376087). Simultaneous disruption of HAD1, PUF4 or LHP1 results in phenotypic enhancement (PubMed:27611567, PubMed:29233914).