Transcription factor that regulates expression of the genes related to ergosterol biosynthesis, including erg3B, erg24A, erg25A, as well as cyp51A that encodes a target protein of azoles (PubMed:30862750, PubMed:28052140). Responsible for the expression of the ABC transporter abcC/cdr1B/abcG1 related to azole resistance (PubMed:28052140, PubMed:30862750). Directly binds both the cyp51A and abcC/cdr1B/abcG1 promoters at a conserved 34 bp region called the atrR response element (ATRE) (PubMed:30862750, PubMed:28052140). AtrR also binds to the promoter regions of both the sterol response transcription factor srbA and atrR genes themselves, the latter suggesting the possibility that atrR is autoregulated (PubMed:30862750). AtrR is necessary for hypoxia adaptation and virulence (PubMed:28052140). Results in a hypersensitivity to the azole drugs fluconazole, miconazole, and itraconazole (PubMed:28052140). In addition to the medical azoles, shows also hypersensitivity to widely used azole fungicides, bromuconazole, tebuconazole, difenoconazole, and propiconazole (PubMed:28052140). Impairs growth under hypoxic conditions and attenuation of virulence in murine infection model for aspergillosis (PubMed:28052140). Cures azole resistant phenotype in a clinical strain with cyp51A G54E mutation (PubMed:28052140).