Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Seems to be also activated by intracellular calcium store depletion. Heteromer with TRPC4 and/or TRPC5 (PubMed:11301024). Interacts with TRPC4 and TRPC5 (By similarity). Interacts with ITPR3 (By similarity). Interacts with MX1 and RNF24 (By similarity). Interacts with FKBP4 (By similarity). Interacts with TRPC4AP (By similarity). Interacts with PLSCR1 (By similarity). Expressed in brain, hippocampus, amygdala, Purkinje cells and single neurons in the cortex and striatum. Activation of PRKCA induces phosphorylation of TRPC1 and subsequent Ca2+ entry into cells. Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC1 sub-subfamily.