Pre-60S-associated factor involved in the cytoplasmic maturation of the 60S subunit. Involved in the dissociation and recycling of other late pre-60S factors before newly synthesized large ribosomal subunits enter translation (By similarity). Can complement the growth defect of a yeast mutant lacking REI1 (PubMed:24038679). Required for leaf growth under cold temperature conditions (PubMed:24038679). Can form homodimer. Interacts with RLP24, RPL24A, RPL24B, EBP1 and JJJ1. A number of isoforms are produced. According to EST sequences. No visible phenotype under normal growth conditions. When grown at 10 degrees Celsius, the double mutant seedlings reil1-1 and reil2-1 show growth arrest at two cotyledon stage and die. Belongs to the REI1 family.