Bifunctional adenylate cyclase toxin-hemolysin that plays a crucial role in host colonization. It causes whooping cough by acting on mammalian cells by elevating cAMP-concentration and thus disrupts normal cell function. Adenylate cyclase that is activated by host intracellular calmodulin and catalyzes un-regulated conversion of ATP to cAMP, thereby impairing microbicidal functions of immune effector cells and inducing apoptosis of lung macrophages. Hemolysin that forms small cation-selective membrane channels, leading to hemolytic activity (By similarity). The hemolytic activity of CyaA is weak compared with that of the HlyA of E.coli (By similarity). ATP = 3',5'-cyclic AMP + diphosphate Activated by host calmodulin. The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity. Released in a processed form. Palmitoylated at Lys-860 and Lys-983 by CyaC. The toxin only becomes active when modified in position Lys-983: palmitoylation is required for efficient membrane insertion and pore formation of the acylated Hemolysin chain. In the N-terminal section; belongs to the adenylyl cyclase class-2 family. In the C-terminal section; belongs to the RTX prokaryotic toxin family.