Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. In contrast to RPP8, it does not specifically recognize the Emco5 avirulence protein from Hyaloperonospora parasitica. Belongs to the disease resistance NB-LRR family. RPP8/HRT subfamily. In cv. Columbia and cv. Di-17, this protein is not present due to an unequal crossing over between the RPP8 and RP8HA genes that creates a unique RPP8 gene. Functional and comparative genomics of disease resistance gene homologs