This metalloproteinase hydrolyzes azocasein, and oxidized insulin B-chain. Also hydrolyzes the alpha-chain (FGA) and more slowly the beta-chain of fibrinogen (FGB), without affecting the gamma-chain. Does not cleave fibrin. Inhibits endothelial cell adhesion to extracellular matrix proteins such as fibrinogen, fibronectin, vitronectin, collagen I, and collagen IV. Induces apoptosis in vascular endothelial cells (By similarity). Binds 1 zinc ion per subunit. Heterodimer; disulfide-linked. Expressed by the venom gland. Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIc sub-subfamily.