Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during the S phase. Acetylates the cohesin component SMC3. acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] Nuclear in interphase cells, excluded from chromosomes during metaphase but reassociates with chromosomes in telophase. At 14.5 dpc the expression is detected in developing murine lip, eyelid, palate, digit, tongue and hair follicles. Its expression is also observed in the long bones of the developing forelimb but not the hindlimb. The N-terminal region seems to be responsible for association with chromosomes, thus excluding any involvement of the Zn finger in this process. Belongs to the acetyltransferase family. ECO subfamily. Truncated C-terminus.