Has a role in resistance to insecticide lufenuron, but no other insecticides. Expression in third-instar larvae is detected in the midgut and Malpighian tubules of both lufenuron-resistant and wild-type strains, higher expression level is seen in lufenuron-resistant strains. Bari1 transposable element insertion in the 3' end of the gene leads to ten-fold more abundant expression than in flies lacking the insert. Belongs to the cytochrome P450 family.