Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). Plays a role in regulating Rho-mediated dorsal closure during embryogenesis. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-1022 (activation loop of the kinase domain) and Thr-1164 (turn motif), may be needed to be phosphorylated for its full activation (By similarity). Kinase activity is activated upon binding to GTP-bound Rho/Rac GTPases. Interacts (via N-terminus) with Rho1 (via REM repeats), Rac1 (via REM 1 repeat) and Rac2. Expressed at the leading edge (LE) cells and in two pairs of discontinuous stripes on the epidermis of each segment at stage 13. Expressed in the anterior and posterior spiracles, the pharynx and the mouth tip at stage 16. Phosphorylated (By similarity). Autophosphorylated; autophosphorylation is stimulated by GTP-bound Rho/Rac GTPases. Embryonic lethal due to defects in dorsal closure. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.