Receptor for neuromedin-B (By similarity). Contributes to the maintenance of basal sigh rate through signaling in the pre-Botzinger complex, a cluster of several thousand neurons in the ventrolateral medulla responsible for inspiration during respiratory activity (By similarity). Contributes to the induction of sneezing following exposure to chemical irritants or allergens which causes release of NMB by nasal sensory neurons and activation of NMBR-expressing neurons in the sneeze-evoking region of the brainstem (By similarity). These in turn activate neurons of the caudal ventral respiratory group, giving rise to the sneezing response (By similarity). Contributes to induction of acute itch, possibly through its activation on dorsal root ganglion neurons by the NMB peptide (By similarity). Plays a role in the innate immune response to influenza A virus infection by enhancing interferon alpha expression and reducing expression of IL6 (By similarity). Plays a role in CSF1-induced proliferation of osteoclast precursors by contributing to the positive regulation of the expression of the CSF1 receptor CSF1R (By similarity). Highly expressed in peripheral tissues where it is detected in the respiratory system, circulatory system, digestive system, urogenital system, lymphatic organs and endocrine system (at protein level) (PubMed:27010315). In the testis, expressed mainly in Leydig cells (at protein level) (PubMed:29632025). During the sow estrus cycle, highest levels are found in the hypothalamus at proestrus and estrus with a significant drop at metestrus and an increase at diestrus. In the pituitary gland, expression increases from proestrus to estrus, drops at metestrus and increases at diestrus. In the ovary, expression increases from proestrus to estrus, drops at metestrus and remains at a similar level at diestrus. During boar postnatal development, expression peaks in the hypothalamus at day 30 and decreases thereafter. In the pituitary gland, expression peaks at day 60, drops slightly at day 90 and increases again at day 120. In the testis, expression drops from day 3 to day 30 with peak levels at day 90 and a decrease at day 120. Belongs to the G-protein coupled receptor 1 family.