Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Component of the large ribosomal subunit (By similarity). Interacts with CRY1 (PubMed:19129230). Hydroxylated on His-216 by RIOX1. The modification is impaired by hypoxia. Belongs to the universal ribosomal protein uL2 family.