Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases. Trimethylation of Lys-116 observed in other calmodulins is absent here. This protein has four functional calcium-binding sites. Belongs to the calmodulin family.