Substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Promotes KAT7 ubiquitination and subsequent degradation in collaboration with MAP2K1 kinase, leading to reduced histone H3K14 acetylation and increased cell proliferation. Protein modification; protein ubiquitination. Part of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Interacts with KAT7 and SKP1. Specifically expressed in oocytes from follicles of the medullary region of the ovary. Detected at 18 dpc, and then decreases thereafter to a very low level at the day of birth. Detected again at 48 hours postpartum, and then increases at 96 hours until 6 days after birth. Up-regulated in response to bacterial lipopolysaccharides (LPS).