Key regulator of adhesion dynamics, it acts as an anti-adhesive. Plays a critical role in the regulation of cell-cell adhesion, multi-cellular development and, in particular, the formation of the organising center known as the tip. Required for turnover of paxillin-adhesion sites during cell migration. Plays a major role in normal cell shape, cell-substrate adhesion and actin cytoskeleton organization. It is present during all stages of starvation-induced multicellular development. It is 5.7-, 6.5- and 10.9-fold higher at 8, 16 and 24 h, respectively after starvation. By starvation. Loss of FrmA leads to increased cell-cell adhesion and results in impaired multi-cellular development, slug migration and fruiting bodies. Mutants show increased adhesion because of an increased number, persistence and mislocalization of paxillin rich cell-substrate adhesions, which is associated with decreased motility. FrmA null cells are unable to efficiently sort to the apex of mounds and form the organising center known as the tip. They also show a delayed expression of LagC.