Plays a role in vesicular protein sorting (By similarity). Acts at the crossroads between the secretory and endocytic pathways. Is involved in the endosome to vacuole protein transport and, as component of the membrane-associated retromer complex, is also involved in endosome-to-Golgi retrograde transport (By similarity). Also involved in the efficient sorting of seed storage protein globulin 12S. Homodimer. Heterodimer with SNX1 or SNX2A. Component of the retromer complex which consists of VPS29 (MAG1), VPS26 (VPS26A or VPS26B), VPS35 (VPS35A or VPS35B or VPS35C), VPS5/17 (SNX1 or SNX2A or SNX2B). Ubiquitously expressed but at a lower level in flowers, siliques, and senescing leaves. The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization. Reduced rosette size and inflorescence length as well as root gravitropism defects in snx2a and snx2b double mutant. Accumulation of storage protein globulin 12S in dry seeds. Belongs to the sorting nexin family. Truncated N-terminus.