Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:14528312, PubMed:13679922, PubMed:23918937). Controls degradation of microtubule severing protein mei-1 after meiosis (PubMed:14528312). Controls degradation of ppfr-1, the regulatory subunit of PP4 complex, after meiosis (PubMed:23918937). In body wall muscles, involved in the organization of myosin thick filaments, likely by regulating the degradation of mei-1 downstream of unc-89 (PubMed:22621901). May also activate the TORC1 pathway (PubMed:29769719). Protein modification; protein ubiquitination. Interacts (via BTB domain) with cul-3 (PubMed:13679922, PubMed:14528312, PubMed:22621901). Seems to be a component of a E3 ubiquitin-protein ligase complex containing cul-3 (PubMed:13679922, PubMed:14528312). Interacts (probably via MATH domain) with mei-1, which targets mei-1 for ubiquitin-mediated proteolysis (PubMed:14528312, PubMed:22621901, PubMed:23918937). Interacts (probably via MATH domain) with ppfr-1, the regulatory subunit of the PP4 complex; targets ppfr-1 for ubiquitin-mediated proteolysis (PubMed:23918937). May interact (via MATH domain) with unc-89 (via Ig-like C2-type domain 2/3 and, Ig-like C2-type domain 50 and fibronectin type-III domain 2) (PubMed:22621901). Colocalizes with unc-89 to the M line. Expressed in body wall muscles. RNAi-mediated knockdown at L1 larval stage results in the disorganization of myosin thick filaments in adult body wall muscles characterized by the formation of abnormal myosin heavy chain myo-3 aggregates and V-shaped crossing of A-bands (PubMed:22621901). RNAi-mediated knockdown of mel-26 also results in increased lifespan (PubMed:29769719).