Major pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including azoles such as fluconazole (FLC), itraconazole (ITC), posaconazole (POS), and voriconazole (VRC) (PubMed:25630649, PubMed:29378705). Is also able to efflux the eukaryote protein synthesis inhibitor cycloheximide (CHX) (PubMed:29378705). ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate ATP + H2O + voriconazole(in) = ADP + H(+) + phosphate + voriconazole(out) ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate Expression is induced in the presence of fluconazole (FLC). Results in drastically higher susceptibility to fluconazole (FLC), itraconazole (ITC), voriconazole (VRC), as well as to the eukaryote protein synthesis inhibitor cycloheximide (CHX). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.