a (3S)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH a (3S)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O a 4-saturated-(3S)-3-hydroxyacyl-CoA = a (3E)-enoyl-CoA + H2O a (3Z)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA a (3E)-enoyl-CoA = a 4-saturated (2E)-enoyl-CoA In the N-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. In the C-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.