During embryonic development, interferes with neural crest formation. Inhibits AP2 transcriptional activity by interaction with its activation domain (By similarity). Interacts with TFAP2A; this interaction inhibits TFAP2A transcriptional activation. In the brain, localizes to the arcuate hypothalamic nucleus, the ventromedial hypothalamic nucleus and the accumbens nucleus of the ventral striatum. Localizes to neurons in areas of the cerebral cortex, cerebellum and hypothalamus (at protein level).