May be involved in both signal transduction and cellular adhesion in the CNS. May have specific signaling roles in the tyrosine phosphorylation/dephosphorylation pathway in the anterior compartment of the adult cerebellar cortex. H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Expression is restricted to the CNS. Distributed throughout the brain and spinal cord. Exceptionally high levels found in the cortex and olfactory bulbs during perinatal development and are down-regulated during postnatal week 2. Expression in the cerebellar cortex is restricted to the granule cell layer of lobules 1-6. Anterior and posterior compartments become discernible only during postnatal weeks 2 and 6. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.