Pseudouridylate synthase that catalyzes pseudouridylation of RNAs, such as tRNAs and mRNAs. a uridine in tRNA = a pseudouridine in tRNA a uridine in mRNA = a pseudouridine in mRNA Neurological defects, characterized by behavioral disorders, including increased activity, disorientation, and aggressiveness (PubMed:30526862). Impaired pseudouridylation oF tRNAS (PubMed:30526862). Belongs to the pseudouridine synthase TruD family.