Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). Homodimer (By similarity). Interacts with FYN (PubMed:12681493). Interacts with PTPRC (By similarity). Interacts with GRB2 when phosphorylated on Tyr-268 (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability (By similarity). Part of a complex consisting of SKAP1, FYB1 and CLNK (PubMed:12681493). Interacts with RASGRP1 (By similarity). Interacts with FYB2 (By similarity). Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. The SH3 domain interacts with FYB1. Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-268 is required for GRB2 interaction (By similarity). Phosphorylation by FYN on Tyr-291 abolishes interaction with FYB1. Tyr-237 is dephosphorylated by PTPRC (By similarity). Belongs to the SKAP family.