Pkc-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. May play a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion and transcription activation signaling processes (By similarity). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Kinase activity is activated upon binding to GTP-bound Rho/Rac GTPases. Activated by lipids, particularly cardiolipin and to a lesser extent by other acidic phospholipids and unsaturated fatty acids. Two specific sites, Thr-809 (activation loop of the kinase domain) and Thr-951 (turn motif), may be needed to be phosphorylated for its full activation (By similarity). Autophosphorylated. Phosphorylated. Proteolytically cleaved. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.