Member of a two-component regulatory system HprR/HprS involved in response to hydrogen peroxide (PubMed:25568260, PubMed:27983483). Senses H(2)O(2), maybe via the redox state of the membrane (PubMed:27983483). Activates HprR by phosphorylation (PubMed:15522865). Can also phosphorylate CusR (PubMed:15522865). ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Autophosphorylated. HprSR and CusSR form a unique regulation system, where both two-component systems recognize and regulate the same set of genes, but under different environmental conditions. HprSR plays a role in H(2)O(2) response regulation, while CusSR plays a role in Cu(2+) response regulation.