Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. a beta-lactam + H2O = a substituted beta-amino acid Binds 2 Zn(2+) ions per subunit. Inhibited by Hg(2+) or Cu(2+), and by chelating agents such as EDTA and O-phenanthroline. Reduced enzymatic activity in presence of cobalt, nickel, cadmium, and manganese. Unstable below pH 8, unless zinc is present. Homotetramer. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.