Precursor protein for pituitary hormones that regulate stress and environmental adaptation. Stimulates the adrenal glands to release cortisol. Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Expressed in the pituitary gland. Residues 16-17 were deduced from the amino acid composition and by homology with other mammalian corticotropins. Belongs to the POMC family.