Palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates (PubMed:25025157). Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (PubMed:25025157). Thereby, indirectly regulates GABAergic synaptic transmission (PubMed:25025157). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family.