Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity (By similarity). Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization (By similarity). Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1 (By similarity). Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B (By similarity). Participates in IFNB promoter activation via TICAM1 (By similarity). Homodimer (By similarity). Interacts with IKBKE, TBK1 and TICAM1 (By similarity). Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation.