Confers resistance to zinc, cadmium and lead. Couples the hydrolysis of ATP with the export of zinc, cadmium or lead. ATP + H2O + Pb(2+)(in) = ADP + H(+) + Pb(2+)(out) + phosphate ATP + H2O + Zn(2+)(in) = ADP + H(+) + phosphate + Zn(2+)(out) ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate Has two high-affinity metal-binding sites, one in the N-terminal region and another in the transmembrane region. Both sites are able to access and bind metal ion independently of each other. The N-terminal metal-binding site is not strictly necessary for activity and metal selectivity, but is needed for maximal activity and may be involved in regulation. The metal-binding site in the transmembrane region is essential for activity of the pump. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.