Probable essential component of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:17626846). Regulates cell proliferation during embryonic and larval development (PubMed:11864567, PubMed:11864566). Involved in synapse elimination in early synapse development (PubMed:17626846). May negatively regulate the apoptotic activity of cep-1 in response to genotoxic stress (PubMed:18340346). Plays a role in sex determination (PubMed:18718460). Probable component of the SCF(sel-10) E3 ubiquitin-protein ligase complex containing F-box domain-containing protein sel-10 as the substrate recognition component (PubMed:17626846). Interacts with cul-1 (PubMed:11864567, PubMed:11864566). May interact with the F-box protein mec-15 (PubMed:11864566). Interacts with dre-1 (PubMed:17336909). Interacts with syg-1 (PubMed:17626846). Interacts with sel-10 (PubMed:18718460). Ubiquitously expressed in the adult. The majority of animals are either embryonic or larval lethal. Rare surviving animals develop into uncoordinated sterile adults with hyperplasia of tissues including the uterus and the spermatheca of the somatic gonad (PubMed:18718460). RNAi-mediated knockdown results in a reduction in brood size of the injected parent and embryonic lethality of offspring between gastrulation and the two-cell phase of embryogenesis (PubMed:11864566). RNAi-mediated knockdown causes synapse clusters that are retained rather than eliminated in the secondary synapse region, anterior to the vulva during synapse development (PubMed:17626846). RNAi-mediated knockdown leads to an increase in germ cell apoptosis in response to genotoxic stress (PubMed:18340346). RNAi-mediated knockdown within 16 hours of RNAi administration results in defects in embryonic divisions including spindle mispositioning, abnormal polar bodies and ectopic furrows, and hyperplasia of the somatic gonad and hypodermis in larvae (PubMed:11864567). All embryos laid 16 hours post RNAi treatment arrest and contain almost twice the number of cells as wild-type embryos (PubMed:11864567). Zygotic RNAi-mediated knockdown results in 90% sterility (PubMed:11864567). Belongs to the SKP1 family.