Nucleoside transport protein that can transport adenosine, uridine, thymidine, cytidine and deoxycytidine (PubMed:374403, PubMed:11466294, PubMed:14668133, PubMed:15678184). Shows weak activity with inosine and xanthosine (PubMed:11466294, PubMed:14668133). Transport is driven by a proton motive force (PubMed:374403, PubMed:14668133). Does not transport guanosine, deoxyguanosine, hypoxanthine or uracil (PubMed:374403, PubMed:14668133). Also shows activity with the chemotherapeutic drugs 3'-azido-3'-deoxythymidine (AZT), 2',3'- dideoxycytidine (ddC) and 2'-deoxy-2',2'-difluorocytidine (gemcitabine) (PubMed:14668133). adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out) H(+)(in) + uridine(in) = H(+)(out) + uridine(out) H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out) cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out) 2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out) Transport is inhibited by the proton uncoupler dinitrophenol (PubMed:374403). Inhibited by the nucleoside antibiotic showdomycin (PubMed:374403). Binding of nucleosides to NupC requires the presence of hydroxyl groups at the C-3' position of ribose. Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.