Catalyzes the activation of medium/long-chain fatty acids as acyl-coenzyme A (acyl-CoA) (PubMed:15984864, PubMed:19182784, PubMed:25490545). May play a role in the uptake of fatty acids by trapping them metabolically as CoA esters (PubMed:25490545). May also play an important role in the channeling of fatty acids into triacylglycerol (TAG) for use by Mycobacterium during its dormancy (PubMed:25490545). a medium chain fatty acid + ATP + CoA = a medium-chain fatty acyl-CoA + AMP + diphosphate a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate ATP + CoA + hexanoate = AMP + diphosphate + hexanoyl-CoA ATP + CoA + octanoate = AMP + diphosphate + octanoyl-CoA ATP + CoA + decanoate = AMP + decanoyl-CoA + diphosphate ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA 9-decenoate + ATP + CoA = 9-decenoyl-CoA + AMP + diphosphate (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate 2-hydroxyhexadecanoate + ATP + CoA = 2-hydroxyhexadecanoyl-CoA + AMP + diphosphate 3-hydroxytetradecanoate + ATP + CoA = 3-hydroxytetradecanoyl-CoA + AMP + diphosphate 12-hydroxyoctadecanoate + ATP + CoA = 12-hydroxyoctadecanoyl-CoA + AMP + diphosphate 15-hydroxypentadecanoate + ATP + CoA = 15-hydroxypentadecanoyl-CoA + AMP + diphosphate 16-hydroxyhexadecanoate + ATP + CoA = 16-hydroxyhexadecanoyl-CoA + AMP + diphosphate 2-methylhexadecanoate + ATP + CoA = 2-methylhexadecanoyl-CoA + AMP + diphosphate 3-methylundecanoate + ATP + CoA = 3-methylundecanoyl-CoA + AMP + diphosphate 12-methyltridecanoate + ATP + CoA = 12-methyltridecanoyl-CoA + AMP + diphosphate 12-methyloctadecanoate + ATP + CoA = 12-methyloctadecanoyl-CoA + AMP + diphosphate Expression is significantly increased during in vitro dormancy (at protein level). Deletion mutant displays a diminished ability to synthesize acyl-coenzyme A in cell-free extracts. Deletion of the gene results in a significant decrease in the accumulation of intracellular triacylglycerol (TAG) in Mycobacterium under dormancy-inducing conditions in vitro. Stimulates fatty acid uptake in E.coli cells. Belongs to the ATP-dependent AMP-binding enzyme family.