Transcription regulator involved in NGFR/p75(NTR)-mediated apoptosis. Essential component of the NGFR/p75(NTR) apoptotic pathway: upon ligand-binding and subsequent cleavage of NGFR/p75(NTR), binds to the intracellular domain (ICD) cleavage product of NGFR/p75(NTR), translocates to the nucleus and induces apoptosis, possibly by regulating expression of key regulators of apoptosis. Induces NGFR/p75(NTR)-mediated apoptosis in retina and sympathetic neurons. May also regulate expression of neuronal cholesterol biosynthesis genes. Probably acts as a transcription repressor: specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. Interacts with NGFR/p75(NTR). Interacts (via KRAB 1 domain) with TRAF6. Interacts (when ubiquitinated at Lys-15) with SQSTM1/p62. Translocates into the nucleus following binding to TRAF6 and subsequent ubiquitination at Lys-15. Ubiquitously expressed at low level. Expressed at higher level in testis. Ubiquitinated by TRAF6 at Lys-15 through 'Lys-63'-linked polyubiquitination. 'Lys-63'-linked polyubiquitination occurs in response to NGFR/p75(NTR) cleavage by gamma-secretase and promotes binding with the ICD cleavage product of NGFR/p75(NTR), followed by translocation into the nucleus and subsequent apoptosis. Lethal in a C57BL/6 background, while mice in a 129/Sv background are viable and healthy to adulthood. Mice in a C57BL/6 background do not survive beyond 12 dpc. Mice in a 129/Sv background may survive due to the presence of Nrif2/Zfp369, which is up-regulated in Nrif1 mutant mice in the 129/Sv background. Belongs to the krueppel C2H2-type zinc-finger protein family. Extended N-terminus. Extended N-terminus.