Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis. Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88. Interacts with IFT57, IFT88 and DAW1. Interacts with ARL13B. Interacts with TTC26/IFT56. Interacts with TTC25 (PubMed:25860617). Interacts with TTC30B (PubMed:23810713). Expression is concentrated at the cilium basal body but is also detected along the length of the cilium. Strongly expressed in ovary and testis, moderately expressed in kidney and brain, and weakly expressed in thymus, heart, lung, liver, spleen and muscle. Expressed in embryonic bone and cartilage, with high expression in non-hypertrophic chondrocytes and weaker expression in hypertrophic chondrocytes. Expressed from 8 dpc throughout embryonic development, with levels increasing at 12.5 dpc and remaining constant thereafter. Up-regulated during chondrocyte maturation and skeletogenesis. By BMP2. Short cilia. Belongs to the IFT46 family.