EMS16 is a potent and selective inhibitor of alpha-2/beta-1 (ITGA2/ITGB1) integrin and acts as a potent antagonist of platelet aggregation and cell migration. Binds specifically to the I domain of the alpha-2 subunit, in a metal ion-independent fashion. Heterodimer of subunits A and B; disulfide-linked. Expressed by the venom gland. Belongs to the snaclec family.