Involved in the nuclear export of mRNA from the nucleus to the cytoplasm. Heterodimer with NXT1. The formation of NXF1/NXT1 heterodimers is required for the NXF1-mediated nuclear mRNA export. Part of the exon junction complex (By similarity). The leucine-rich repeats and the NTF2-domain are essential for the export of mRNA from the nucleus. Changing a single residue, Gln-246 to Arg, the residue found in human NXF1, fully rescues both constitutive transport element (CTE) function and CTE binding. Belongs to the NXF family.