Transcription factor required for development of the vascular component of the pronephric kidney, the glomus; may repress tubule-specific gene expression in the portion of the pronephros fated to form the glomus. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3' (By similarity). Inhibits Wnt-signaling during embryonic development. Function may be isoform-specific: the isoform containing the KTS motif is less effective in inhibiting wnt signaling. Shuttles between nucleus and cytoplasm. Expressed around the pronephric anlage and in the pronephros; expression is restricted to the splanchnic mesoderm (the site where the glomus forms) from tailbud stages, and the glomus of early tadpoles. Not expressed in the pronephric tubules or pronephric duct. In tadpoles (stage 38-39), additional expression begins in the heart. Also expressed in the adult kidney (mesonephros). Expression begins around stage 18 (late neurula). By retinoic acid in combination with fgf. By lmx1b in combination with lhx1/lim1. Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers. Starting from the N-terminus, the second zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine, 5-formylcytosine or 5-carboxylcytosine. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Belongs to the EGR C2H2-type zinc-finger protein family.