Part of the type VI secretion system specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Acts directly as an secreted effector with an actin ADP-ribosyltransferase activity that disrupts the host actin cytoskeleton, leading to a decrease in host cell viability and an increase in apoptosis. L-arginyl-[protein] + NAD(+) = H(+) + N(omega)-(ADP-D-ribosyl)-L-arginyl-[protein] + nicotinamide Belongs to the VgrG protein family.