Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate in the novobiocin biosynthesis pathway, an aminocoumarin family antibiotic that targets bacterial DNA gyrases. alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate + dTDP-alpha-D-glucose Binds 1 Mg(2+) ion per subunit. Antibiotic biosynthesis; novobiocin biosynthesis. Belongs to the glucose-1-phosphate thymidylyltransferase family.