Promotes invasion of host epithelial cells by adhering to receptors on the host cell surface to facilitate endocytosis of the pathogen into host cells (PubMed:24355926). Binds HSPA5/BiP protein on the cell surface of host epithelial cells (PubMed:24355926). Interacts with host epithelial cell surface HSPA5/BiP protein. Expressed in spores. Expressed during growth in host lung and brain, and during growth in presence of epithelial cells (PubMed:24355926). Induced in presence of high free iron (at protein level) (PubMed:27159390). Induced during growth in high glucose (at protein level) (PubMed:27159390). Induced in presence of 3-hydroxybutyric acid (BHB) (at protein level) (PubMed:27159390). Simultaneous RNAi-mediated knockdown of CotH2 and CotH3 decreases invasion of host epithelial cells (PubMed:24355926). Simultaneous RNAi-mediated knockdown of CotH2 and CotH3 decreases virulence in a mouse model of ketoacidosis (PubMed:24355926, PubMed:27159390). Simultaneous RNAi-mediated knockdown of CotH2 and CotH3 does not lead to sensitivity to cell wall stress (induced by Congo Red, Calcofluor White, hydrogen peroxide, sodium dodecyl sulfate, or Triton X-100) (PubMed:24355926). Antibodies against CotH2 protects mice from mucormycosis, and thus could potentially be used to treat the disease.