May have a lysine N-acetyltransferase activity catalyzing peptidyl-lysine N6-acetylation of various proteins. Thereby, may regulate apoptosis through the acetylation and the regulation of the expression of PROM1. May also regulate amyloid beta-peptide secretion through acetylation of BACE1 and the regulation of its expression in neurons. Interacts with PROM1. Interacts with BACE1. Enriched in the endoplasmic reticulum-Golgi intermediate compartment. Expressed in brain (at protein level). Belongs to the camello family. Could be the product of a pseudogene. However an antibody which recognizes both Nat8 and Nat8B detects a product of approximately 27 kDa in brain extracts, which provides some evidence for existence of this protein (PubMed:22267734).