Effector showing tyrosine-phosphatase activity required for host defense suppression. Functions inside plant cells causing suppression of HR (hypersensitive response), PR1 gene expression and oxidative burst probably by interfering with a MAPK (mitogen-activated protein kinase) pathway. MAPK cascades are known to activate defense-related transcription factors. Inhibits plant pattern-recognition receptors (PRRs) activation. H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Inhibited by sodium orthovanadate. Interacts with EFR and FLS2 (via the kinase and cytoplasmic domains). Secreted via type III secretion system (TTSS). Transcriptionally induced by HrpL. The N-terminal domain (residues 1-142) retains 70% identity to the N-terminal 142 residues of AvrPphD, and is required for translocation into plant cells via TTSS. HopPtoD2 is not present in all strains of P.syringae.