Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:11572992, PubMed:29281266, PubMed:7592783, PubMed:30304478, PubMed:32144205). 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+) 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+) 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+) 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+) H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP Binds 2 Mg(2+) ion per subunit. Monomer. High expression levels detected in thymus, liver, spleen, kidney, testis and large intestine, with lower levels detected in brain, heart, lung and stomach (at protein level). Expressed in kidney, liver and small intestine. Mutant mice appear normal, but have higher incidence of tumors in lung, liver and stomach. Belongs to the Nudix hydrolase family.