Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates transcription of the p21 promoter (By similarity). Activates RIPK4 transcription. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Binds 1 zinc ion per subunit. Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Interacts with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Interacts with PDS5A. Interacts (via activation domain) with NOC2L (By similarity). Interacts with WWP1. Widely expressed, notably in thymus, prostate, placenta and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms. Expressed in the basal layer and a small number of cells in the spinous layer of the tongue at P20. Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification. Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation. Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification. Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation. Expressed in the epidermis from 7.5 dpc, prior to onset of epithelial stratification. Expressed in the epidermis from 9.5 dpc, after the onset of epithelial stratification but prior to terminal differentiation. Induced by DNA damaging agents. The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms. May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. Produced by alternative promoter usage. Produced by alternative promoter usage. Produced by alternative splicing of isoform 1. Produced by alternative splicing of isoform 2. Produced by alternative splicing of isoform 1. Produced by alternative splicing of isoform 2. Belongs to the p53 family. Intron retention.