Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity. Functions in somitogenesis. Functions as a regulator of the biochemical clock responsible for the segmentation of the presomitic mesoderm. H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate First detected in somites, pronephric duct, midbrain hindbrain boundary, otic vesicle and retina 10-24 after fertilization. When somite formation is complete expression becomes restricted to the retina, the forebrain midbrain, the midbrain hindbrain boundary, the otic vesicle and the branchial arches. Embryos lacking ptpru display severe disruption of their segmental pattern and loss of cyclic gene expression in the presomitic mesoderm. Convergent extension during gastrulation is also affected. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.