Negatively regulates tyramine beta-hydroxylase tbh and thus the conversion of tyramine (TA) to octopamine (OA). In tyrosine decarboxylase 2 (Tdc2) neurons, acts in an amine-mediated signaling pathway to negatively regulate acute ethanol sensitivity probably via tbh-mediated depletion of TA. Expressed in the brain. In embryos, first expressed in the ganglion mother cells (GMCs) of the central nervous system (CNS) and the sensory organ precursors (SOPs) of the peripheral nervous system (PNS). At stage 14, it is no longer detected in the lateral PNS. Expressed in the antenno-maxillary complex from stage 14 and throughout stage 15. RNAi-mediated knockdown in neurons causes a reduction in sensitivity to ethanol intoxication.