Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Expressed in the developing head and limbs (PubMed:25759469). Expressed broadly in cranial ectoderm. Also expressed in the developing somites (dermomyotome) and in other cranial placodes, including the olfactory, lens, and otic placodes (rostral rim of the vesicle). At stage 8, faintly expressed in cranial ectoderm and in the somites. At stages 9-10, broadly expressed throughout the cranial ectoderm. By stages 11-12, more robust expression is detected in ectoderm adjacent to the hindbrain, including the otic placodes. Transiently expressed in the lens placode and ectoderm of the head at stages 13-15. Down-regulated in differentiating structures of older embryos. Lys-Thr-X-X-X-Trp motif interacts with the PDZ domain of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway. The FZ domain is involved in binding with Wnt ligands. Belongs to the G-protein coupled receptor Fz/Smo family.