Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity. The B subunit binds ATP (By similarity). ATP-dependent breakage, passage and rejoining of double-stranded DNA. Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits (Probable). Interacts with SPO11-4. Belongs to the TOP6B family.