Inhibits protein synthesis (PubMed:10213004, PubMed:20174685). Has adenine polynucleotide glycosidase activity on herring sperm (hs)DNA and poly(A) substrates (PubMed:20174685). Cleaves supercoiled pBR322 dsDNA (PubMed:15899692, PubMed:19452522). Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. Expressed in leaves (at protein level). Detected in developing and mature leaves of adult plants. Levels of PD-L1 are highest during the winter, levels of PD-L2 remain constant throughout the year. Not detected in young (8-34 month old) plants. N-glycosylated (PubMed:19452522, PubMed:20174685). Loss of glycosylation does not affect DNA-cleaving ability (PubMed:19452522). Loss of glycosylation does not affect protein synthesis inhibition, but increases adenine polynucleotide glycosidase activity likely as a consequence of the increased accessibility of substrates to the active site pocket in the absence of glycosylation (PubMed:20174685). PD-L1. PD-L2. PD-L2. 2 forms exist, PD-L1 and PD-L2, that differ in their post-translational modifications. Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.