Regulates the response of astrocytes to hypo-osmosis by promoting calcium influx. Interacts with ATP1B1. Part of a complex containing ATP1B1, TRPV4, AQP4 and HEPACAM. Expressed in the brain, with highest levels found in the amygdala, nucleus caudatus, thalamus and hippocampus. The disease is caused by variants affecting the gene represented in this entry. Leiden Open Variation Database (LOVD)