Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (PubMed:30455415). Interacts with SLIT2 and ENAH. Specifically expressed in endothelial cells. Expressed in endothelial and intimal cells of the ascending aorta (PubMed:30455415). Disease susceptibility is associated with variants affecting the gene represented in this entry. Belongs to the immunoglobulin superfamily. ROBO family.