Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). Binds to the receptor tyrosine kinase EPHB2. Interacts with GRIP1 and GRIP2 (By similarity). Inducible phosphorylation of tyrosine residues in the cytoplasmic domain. Belongs to the ephrin family.