Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Increases intracellular free calcium level (PubMed:20889719). Decreases urease activity (PubMed:29113016). Decreases concentration of the polysaccharide glucuronoxylomannan in growth medium (PubMed:20889719). Decreases RNA level of ECA1 (PubMed:20889719). Increases RNA level of PMR1 and PMC1 (PubMed:20889719). Sensitive to cyclosporine A in combination with; semi-permissive high temperature, or calcium chloride (PubMed:20889719). Resistance to cyclosporine A in combination with cadmium (PubMed:20889719). Normal cell wall integrity (PubMed:20889719). Normal capsule size (PubMed:20889719). Decreases virulence in a mouse intranasal inhalation infection model (PubMed:20889719). Normal virulence in a mouse systemic infection model (PubMed:29113016). Decreases susceptibility to phagocytosis by macrophages (PubMed:20889719, PubMed:29113016). Enhances calcium sensitivity of PMC1 disruption mutant (PubMed:23895559). Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.