May participate in amyloid-beta-induced apoptosis via its interaction with beta-APP42. Interacts with APP beta-APP42 (amyloid-beta protein 42). Widely expressed. N-glycosylated. Belongs to the TM2 family. Was originally (PubMed:11278849) thought to modulate amyloid-beta toxicity by coupling to G protein. However, PubMed:12836168 showed that this effect is not direct.