May play a role in the process of maturation of dendritic cells (By similarity). Required for the development of cerebellar granule cells. Ubiquitously expressed with higher expression in lung, liver, kidney and colon. Expressed in cerebellar granule cells. Expressed in the developing cerebellum at constant levels from 18 dpc to P7. Mice exhibit abnormal development of the cerebellum and severe ataxia. Belongs to the TMEM176 family.