Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I. Interaction with ATP6AP2 results in a 5-fold increased efficiency in angiotensinogen processing. Interacts with ATP6AP2. Associated to membranes via binding to ATP6AP2. Belongs to the peptidase A1 family.