Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity). Involved in the maintenance of endothelial barrier organization and function (By similarity). Interacts with SLIT2 and ENAH. Belongs to the immunoglobulin superfamily. ROBO family.