This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity). Binds to TIPF39/TIP39. Expressed abundantly in brain and pancreas. Also expressed in the testis. Belongs to the G-protein coupled receptor 2 family.