This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin. Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat. The DM-20 protein is the major proteolipid component in fetal brain. With the appearance of white matter (27-30 weeks of gestation), levels of DM-20 begin to increase significantly and then, dramatically, from weeks 31-40 reaching maximum levels in adulthood. In contrast, PLP is not detected until weeks 31-35 after which levels greatly increase and it becomes the major proteolipid in adults. Palmitoylated; contains four to five bound palmitate, probably attached in a non-stoichiometric manner. Belongs to the myelin proteolipid protein family.