May be involved in both signal transduction and cellular adhesion in the CNS. H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Expressed in colon, lung, heart and testis, as well as in fetal and adult brain. Not detected in muscle and peripheral blood leukocytes. Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Extended N-terminus.