Protease capable of hydrolyzing gelatin and cell surface heparan sulfate proteoglycans (HSPGs) in vitro. Inhibited by serine protease inhibitors phenylmethanesulphonylfluoride (PMSF) and di-iodopropylfluorophosphate (DFP). Optimum pH is 9. Activity is relatively stable between pH 8-10 but drops at lower pH and is absent at pH 4. Optimum temperature is 45 degrees Celsius. Monomer. Belongs to the peptidase S8 family.