Transcription factor that is involved in the response to heat shock, oxidative stress, and poor nutrient conditions (PubMed:22345349). Controls expression of oxidative stress response genes such as ccp1, cat1, cat2, sod2; as well as of heat shock genes such as hsf1, hsp30 and hsp90 (PubMed:22345349). Negatively controls the expression of the fumiquinazoline (fmq) cluster via binding to the STRE motifs at the fmqA-D promoters (PubMed:33705521). Plays a role in virulence (PubMed:22345349, PubMed:33705521). Accumulates in the nucleus upon exposure to oxidative stress and heat shock conditions. Increases sensitivity calcium and to oxidative stress factors, such as paraquat and H(2)O(2) (PubMed:22345349). Leads to attenuated virulence in a murine model of invasive pulmonary aspergillosis through increased killing by the murine alveolar macrophages (PubMed:22345349). Increases the expression of the fumiquinazoline (fmq) cluster and leads to overproduction of fumiquinazoline C (PubMed:33705521).