May act as a downstream kinase in the sphingolipid-mediated signaling pathway. Plays an essential role in the proliferation of yeast cells. Involved in a signaling pathway, required for optimal cell wall integrity, that acts in parallel with the PKC1-SLT2-dependent pathway. A substrate of TOR complex 2 (TORC2) and required for TORC2 to regulate spatial aspects of cell growth. Phosphorylation of residue Thr-501 is indispensable for function. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by phytosphingosine (PHS), a sphingoid long chain base. Activated by PKH2 phosphorylation. Kinase activity is regulated by TOR2 via direct phosphorylation of Ser-641 and Thr-659. Autophosphorylated (By similarity). Phosphorylated by PKH2 and TOR2. Present with 1310 molecules/cell in log phase SD medium. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily.