Involved in the regulation of the perinuclear actin network and nuclear shape through interaction with filamins. Plays an essential role in the formation of cartilaginous skeletal elements. Interacts with FLNA and FLNB. Colocalizes with FLNA along actin bundle-like structures. Detected in various tissues, with highest expression in lung, followed by spleen. At 15.5 dpc, expressed in developing ribs and nucleus pulposus in intervertebral disks. At 18.5 dpc, expression is detected in proliferating and prehypertrophic chondrocytes. No visible phenotype; probably due to redundancy with RFLN. RFLNA and RFLNB double mutant mice exhibit severe skeletal malformations, as characterized by scoliosis, kyphosis, intervertebral disks defects, vertebral fusion in the spine and longitudinal bone growth retardation. Chondrocyte maturation is accelerated in double mutant mice. Belongs to the Refilin family.