Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (By similarity). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering pro-inflammatory NF-kappa-B signaling (By similarity). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (By similarity). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (By similarity). May play a role in ciliogenesis (By similarity). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Serine/threonine-protein kinase activity is stimulated upon ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose)-binding. Localized to the basal body region of the photoreceptor cilium and the region of the adjacent centriole. Widely expressed (PubMed:30967659). Expressed in the retina and in sweat glands, especially in the myoepithelial cells (PubMed:30967659). Mice show defects in motor coordination (PubMed:21208416). The cerebellar architecture, Purkinje cell morphology and electrophysiology of the Purkinje cells is apparently not affected (PubMed:21208416). Mice display impaired ability to initiate an innate immune response in response to ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose): mice injected with ADP-Heptose show no increase in cytokine production (PubMed:30111836). Belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.