Inhibitor of Ras signaling (PubMed:30442766). Acts as a substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (By similarity). Together with Nf1, plays an important role for normal sleep behavior, mainly during the night (PubMed:32339168). Might affect sleep by modulating GABA signaling in Rdl-expressing neurons (PubMed:32339168). Might play a role in the regulation of brain glycogen metabolism and organismal levels of triglycerides (PubMed:32339168). Protein modification; protein ubiquitination. Component of some BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Expressed in Rdl-expressing neurons of the mushroom body, the neurons projecting to the LC9 optic glomerulus and in a neuronal cluster near the subesophageal ganglion (at protein level). Flies are viable but most wings show wing vein defects characterized by extra veins and vein tissue, which are caused by an increase of Ras-MAPK signaling (PubMed:30442766, PubMed:32339168). Decreases sleep with night-time sleep-fragmentation patterns, primarily during the second part of the night (PubMed:32339168). RNAi-mediated knockdown in neurons of males results in reduced total sleep in combination with decreased locomotor activity, increased Ras-MAPK signaling and altered metabolism including reduced glycogen levels and increased levels of triglycerides (PubMed:32339168). RNAi- mediated knockdown in GABAA-receptor-expressing neurons causes a shortening of sleep bouts and an increase in their number during night, with an effect size similar to that seen with pan-neuronal knockdown (PubMed:32339168). RNAi-mediated knockdown in peripheral class-IV dendritic arborization neurons does not cause increased proliferation in the nervous system (PubMed:32339168). Adult-specific RNAi-mediated neuronal knockdown decreases night-time sleep compared to controls and caused an increased number of short sleep bouts during the night (PubMed:32339168). RNAi-mediated knockdown of in GABAB-receptor-expressing neurons or PDF-expressing clock neurons-had no significant effect on night-time sleep-bout number or duration (PubMed:32339168). Simultaneous knockdown of Lztr1 and Nf1 reduces total night-time sleep, increases night-time sleep fragmentation and activates the Ras pathway similarly to single knockdown (PubMed:32339168). Belongs to the LZTR1 family.