Overexpression in M. smegmatis increases resistance to erythromycin, ampicillin, novobiocin and vancomycin. It also reduces accumulation of ethidium bromide in the cell. Efflux is inhibited by reserpine. The ATP-binding domains (NBD) and the transmembrane domains (TMD) are fused. Belongs to the ABC transporter superfamily. Lipid exporter (TC 3.A.1.106) family.