Involved in extracellular matrix organization (By similarity). Required for the regulation of epidermal-basement membrane adhesion responsible for proper organogenesis during embryonic development (By similarity). Involved in brain organization and function (By similarity). Expressed in many adult tissues, with highest levels in kidney, pancreas and thalamus. Relatively high expression was also detected in fetal kidney and heart. The Calx-beta domains bind calcium with high affinity and undergo a major conformational shift upon binding. The disease is caused by variants affecting the gene represented in this entry. Belongs to the FRAS1 family.