Inhibits Kv11.1/KCNH2/ERG1, Kv1.1/KCNA1 and Kv1.3/KCNA3 voltage-gated potassium channels and Nav1.7/SCN9A voltage-gated sodium channels (PubMed:29483648). In vivo, intracranial injection into mice causes lack of coordination for 10 min, followed by fast recovery. Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Belongs to the neurotoxin 02 (plectoxin) family. 04 (U16-lycotoxin) subfamily.