Catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. Reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. a primary alcohol + NADP(+) = an aldehyde + H(+) + NADPH Inhibited by quercetin, dicoumarol and some SH-reagents. Monomer. Belongs to the aldo/keto reductase family.