Promotes integrin-mediated cell adhesion. May stimulate host defense against viruses and tumor cells (By similarity). Homodimers and homomultimers. The multimers form ring-like structures with a diameter of 30-40 nm. Binds LGALS1 and LGALS3. Binds ITGB1, COL4A1, COL5A1, COL6A1, FN1 and NID (By similarity). Interacts with PPIC (in vitro). The unglycosylated form interacts with PDE4DIP isoform 2/MMG8/SMYLE; this interaction may connect a pericentrosomal complex to the gamma-tubulin ring complex (gamma-TuRC) to promote microtubule assembly and acetylation (By similarity). Detected in embryo, liver, spleen, kidney, lung, heart, intestine, thymus and lymph node. Up-regulated by TNF and IFNG. N-glycosylated.