Essential component of the nuclear pore complex (By similarity). The N-terminal is probably involved in nucleocytoplasmic transport (By similarity). The C-terminal is involved in protein-protein interaction probably via coiled-coil formation, promotes its association with centrosomes and may function in anchorage of Nup62 to the pore complex (By similarity). Binds to transcriptionally active genes (PubMed:20144760). Negatively regulates chromatin attachment to the nuclear envelope, probably by preventing chromatin tethering by Nup154 (PubMed:26341556). Central region of the nuclear pore, within the transporter (By similarity). Associates with chromatin (PubMed:20144760). Expressed in adult male accessory glands (at protein level). Contains FG repeats. FG repeats are interaction sites for karyopherins (importins, exportins) and form probably an affinity gradient, guiding the transport proteins unidirectionally with their cargo through the NPC. FG repeat regions are highly flexible and lack ordered secondary structure. The overall conservation of FG repeats regarding exact sequence, spacing, and repeat unit length is limited. RNAi-mediated knockdown in oocytes results in increased nuclear size. RNAi-mediated knockdown in oocytes and nurse cells results in irregular distribution of chromatin to the nuclear periphery disrupting karyosome morphology. Simultaneous RNAi-mediated knockdown of nucleoporin Nup154 restores normal karyosome formation. Belongs to the nucleoporin NSP1/NUP62 family.