Part of the NCT transcriptional regulatory complex that acts as a key regulator of ergosterol biosynthesis and the azole exporter cdr1B (PubMed:31969561). The NCT complex binds the promoters of genes linked to azole susceptibility, and especially represses the expression of cdr1B transporter (PubMed:31969561). Forms the NCT transcriptional regulatory complex with nctA and mot1. Leads to a multidrug-resistance phenotype, including the azoles (itraconazole, voriconazole and posaconazole), as well as the salvage therapeutic amphotericin B and terbinafine, an agent used in the treatment of chronic and allergic disease (PubMed:31969561). Leads also to transcriptional derepression of cdr1B and its over-production (PubMed:31969561). Results also in a notable increase in the immunogenic properties of Aspergillus fumigatus, but does not result in loss of virulence (PubMed:31969561). Belongs to the NC2 beta/DR1 family.