Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. 3',5'-cyclic GMP + H2O = GMP + H(+) Oligomer composed of two catalytic chains (alpha and beta), an inhibitory chain (gamma) and the delta chain. The disease is caused by variants affecting the gene represented in this entry. Belongs to the rod/cone cGMP-PDE gamma subunit family. Extended N-terminus. Extended N-terminus. Retina International's Scientific Newsletter