Receptor for SLIT2, and probably SLIT1, which are thought to act as molecular guidance cue in cellular migration, including axonal navigation at the ventral midline of the neural tube and projection of axons to different regions during neuronal development. Interacts with SLIT2. Expressed in embryonal spinal chord. Expressed at 11.5 dpc in spinal chord. Mice show defects in commissural axon guidance in spinal cord including an altered lateral and ventral funiculi projection. The phenotype resembles that of a SLIT1;SLIT2;SLIT3 triple mutant. Belongs to the immunoglobulin superfamily. ROBO family.