Plays a role in the establishment of cell polarity and epithelial lumen formation (PubMed:20835237). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (PubMed:27224062). Homodimer (PubMed:12559564). Interacts with OFD1; the interaction is direct (By similarity). Interacts with FAM161A (By similarity). Interacts with RABEP2, ERC1 and CEP131 (By similarity). Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle. Expressed in liver, kidney, spleen, brain, heart and muscle. Expressed in photoreceptor cells of the retina. In renal epithelial cells gene knockdown results in the formation of spheroids with architectural defects characterized by disturbed localization of beta-catenin (CTNNB1) at the basolateral membrane, fewer tight junctions and an irregular lumen (PubMed:20835237). SDCCAG8-deficient mice display developmental bone malformations with rib cage abnormalities.