Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Specifically expressed in skeletal muscle. Up-regulated by triiodothyronine. Probably phosphorylated by PKC; decreases single-channel open probability. Disease susceptibility is associated with variants affecting the gene represented in this entry. Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ12 subfamily.