Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity (By similarity). Interacts with NR2E1; the interaction represses the transcriptional activity of NR2E1. Interact (via its N-terminus) with FAT1 (via a C-terminal domain). Interacts with BAIAP2, WWP1, WWP2, WWP3 and RERE. Interacts (via its N-terminus) with MTG8; the interaction enhances transcriptional repression of MTG8. Interacts with PQBP1 (By similarity). Shuttles between nucleus and cytoplasm. Colocalizes with MTG8 in discrete nuclear dots (By similarity). Colocalizes with FAT1 in the perinuclear area, at cell-cell junctions and leading edges of cells. Predominant neuronal expression, Expressed in most brain regions including striatum, hippocampus, cerebral cortex, diencephalon, brain stem and cerebellum. Highest levels in cerebellum. Also highly expressed in kidney and testis, low expression in skeletal muscle and heart. Similar expression at all development stages (14.5 dpc, 17.5 dpc, newborns and adults). Induced after vascular injury and by growth factors. Decreased levels with INF-gamma. Phosphorylated in vitro by MAPK8/JNK1 on Ser-732.