NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. Plays a role in oxidative stress resistance (PubMed:23438705). Might promote neuronal cell death under ischemic conditions and cell death in touch neurons induced by mec-4 channel hyperactivation, possibly downstream of the insulin-like receptor daf-2 (PubMed:28820880). Might attenuate the reactive oxygen species (ROS) scavenging system, that eliminates ROS in ischemic conditions, under dietary deprivation and when glycolysis is blocked (PubMed:28820880). H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide Binds 1 zinc ion per subunit. Interacts with pyc-1, pcca-1 and mccc-1. Ubiquitously expressed with high expression in the pharynx, body wall muscles and gonad. Strong expression in a subset of non-neuronal cells in the head. Expression starts at the 100 cell stage during embryogenesis and is expressed throughout development until adulthood. This protein may be expected to contain an N-terminal transit peptide but none has been predicted. Belongs to the sirtuin family. Class II subfamily.