Adapter protein that interacts with EDAR DEATH domain and couples the receptor to EDA signaling pathway during morphogenesis of ectodermal organs. Mediates the activation of NF-kappa-B. Self-associates and binds EDAR, TRAF1, TRAF2 and TRAF3. Detected in adult pancreas, placenta and fetal skin, and at lower levels in lung, thymus, prostate and testis. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry.