Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Also plays a role in primitive hematopoiesis, possibly by affecting the expression of genes critical for hematopoiesis (By similarity). Plays a role in cytokinesis during early development. ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by autophosphorylation of the T-loop at Thr-169 and Ser-173: in contrast to other members of the SNF1 subfamily, phosphorylation at Thr-169 is not mediated by STK11/LKB1 but via autophosphorylation instead. The KA1 domain mediates binding to phospholipids and targeting to membranes. Autophosphorylated: autophosphorylation of the T-loop at Thr-169 and Ser-173 is required for activation (By similarity). Phosphorylated by the maturation promoting factor (MPF), composed of cdk1 and a cyclin-B. Also phosphorylated by some MAPK. Phosphorylated during oocyte maturation. Dephosphorylation destabilizes the protein. There is some ambiguity for some phosphosites: Thr-481/Thr-483 and Ser-505/Ser-517. Degraded when cells exit mitosis. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Contaminating sequence. Potential poly-A sequence.