Probable E3 ubiquitin-protein ligase which accepts ubiquitin from the E2 ubiquitin-conjugating enzyme UBE2E1/UBCH6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates ubiquitination of host tumor-suppressor-like protein (TSL) targeting it for degradation. Might function as an anti-apoptosis protein by counteracting TSL-induced apoptosis. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Interacts with host UBE2E1/UBCH6 (Probable); this interaction results in WSV222 auto-ubiquitination. Interacts with host tumor suppressor-like protein. Reduction of host mortality.