Virulence factor that suppresses host Toll-like receptor 2 (TLR2)-mediated NF-kappa-B signaling upon infection (PubMed:24481289, PubMed:28060920). NAD(+) hydrolase (NADase) that catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). Able to reduce NAD(+) levels in host cells (PubMed:29395922). H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.