Molecular adapter that acts as a bridge between a variety of multiprotein complexes, and which is required for embryonic development and for normal innate immune response (PubMed:18066067, PubMed:22396663, PubMed:25180232, PubMed:32950464). Acts as a regulator of embryonic myogenesis by bridging Twist (twi) with the SWI/SNF-like Brahma complex, promoting expression of twi-regulated genes during myogenesis (PubMed:22396663). Effector of immune deficiency pathway (Imd) by acting either downstream of, or at the level of, the NF-kappa-B factor Relish (Rel) (PubMed:18066067, PubMed:25180232, PubMed:32950464). Acts by bridging the NF-kappa-B factor Rel and the Brahma complex through bap60 interaction, leading to activation a subset of NF-kappa-B factor Relish (Rel) effector genes (PubMed:25180232). Not part of the Toll pathway (PubMed:18066067). Required for the formation of the heart by promoting expression ot tinman (tin) (PubMed:32950464). Interacts with dmap1 (PubMed:24947515). Interacts with bap60 and rel; interaction is immune stimulation-dependent; activates selected rel target gene promoters (PubMed:25180232, PubMed:32950464). Interacts with bap55; interaction is immune stimulation-dependent (PubMed:25180232). Interacts with twi (PubMed:22396663). Ubiquitous. Polyubiquitinated via 'Lys-63'-linked ubiquitin by Hyd, promoting interaction with rel. Homozygous embryonic lethal; early to mid embryonic stages (PubMed:18066067). Embryos display a range of somatic body wall muscle defects (PubMed:22396663). Embryos show morphological defects in the heart, such as abnormal spacing between rows of aortic cells and abnormal patterning of the aortic outflow tract (PubMed:32950464). 'Akiraka ni suru' means 'making things clear' in Japanese. The name is given based on the presence of the clear nuclear localization signal. Belongs to the akirin family.