ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met) Optimum pH is 7.8-8.2. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the class-I aminoacyl-tRNA synthetase family. Extended N-terminus. Extended N-terminus.