Converts specifically D-serine to pyruvate and ammonia. May play a role in D-serine detoxification. D-serine = NH4(+) + pyruvate Sodium cyanoborohydride, N-ethylmaleimide, hydroxylamine, phenyhydrazin and EDTA are inhibitors of the catalytic activity. Optimum pH is 8.0. Homodimer. Belongs to the DSD1 family.