Catalytic component of the ISW2 complex, which acts in remodeling the chromatin by catalyzing an ATP-dependent alteration in the structure of nucleosomal DNA. The ISW2 complex is involved in coordinating transcriptional repression and in inheritance of telomeric silencing (By similarity). ISW2 is required for chlamydospore formation, distinctive morphological feature of the fungal pathogen C.albicans that can be induced to form in oxygen-limited environments and has been reported in clinical specimens. Component of the ISW2 complex. Expression is induced by the HAP43 transcription factor and repressed in response to high doses of peroxide stress. Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.