Voltage-gated chloride channel. Chloride channels have several functions including the regulation of cell volume; membrane potential stabilization, signal transduction and transepithelial transport. May be important in urinary concentrating mechanisms. Interacts with BSND. Forms heteromers with BSND in the thick ascending limb of Henle and more distal segments (By similarity). Expressed predominantly in the kidney. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. Loss-of-function of both CLCNKA and CLCNKB results in the disease phenotype (PubMed:18310267). Compared with CLCNKA/BSND, CLCNKB/BSND is more sensitive to pH and less responsive to Ca(2+). Belongs to the chloride channel (TC 2.A.49) family. CLCNKB subfamily.