Participates in tumor necrosis factor-alpha (TNF)-induced cell death. May be a target of Wnt/beta-catenin signaling in the liver. Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By similarity). Co-localizes with MGAT1 and IFITM3 at the perinuclear region. Belongs to the BRI3 family.