Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CUL1, CUL2 and SPK1B/ASK2. The F-box is necessary for the interaction with ASK proteins. Despite the nomenclature given by PubMed:11077244, FBW2 does not contain any WD-40 repeat.