Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (PubMed:11054572). Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5 (By similarity). Forms homo- and heterooligomers with DRD4. The interaction with DRD4 may modulate agonist-induced downstream signaling. Interacts with CADPS and CADPS2 (By similarity). Interacts with GPRASP1, PPP1R9B and CLIC6. Interacts with ARRB2 (By similarity). Interacts with HTR2A (By similarity). Interacts with DRD1. Interacts with KCNA2 (By similarity). Palmitoylated. Palmitoylation which is required for proper localization to the plasma membrane and stability of the receptor could be carried on by ZDHHC4, ZDHHC3 and ZDHHC8. Belongs to the G-protein coupled receptor 1 family.