Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use diadenosine 5',5'''-P(1)P(6) hexaphosphate (Ap(6)A), diadenosine 5',5'''-P(1)P(5) pentaphosphate (Ap(5)A) and adenosine tetraphosphate (p(4)A) as substrates, but not diadenosine 5',5'''-P(1)P(4) tetraphosphate (Ap(4)A), diadenosine 5',5'''-P(1)P(3) triphosphate (Ap(3)A), deoxyribonucleoside triphosphates, ribonucleoside triphosphates, diphosphoinositol pentakisphosphate (PP-InsP(5)) and 5-phospho-alpha-D-ribosyl diphosphate (PRPP). Inhibited by fluoride. Reducing conditions are required for the hydrolytic activity. Optimum pH is 8.5. Optimum temperature is 37 degrees Celsius. Monomer. Expressed in roots, leaves, stems and inflorescences. No visible phenotype under normal growth conditions. Belongs to the Nudix hydrolase family.