Component of the nuclear pore complex, a complex required for the trafficking across the nuclear membrane. Component of the p62 complex, a complex composed of NUP62, NUP54, and the isoform p58 and isoform p45 of NUP58. Interacts with NUTF2. Biased towards cytoplasmic side. Central region of the nuclear pore complex, within the transporter. Contains FG repeats. O-glycosylated. Belongs to the NUP54 family.