Conversion of dopamine to noradrenaline. dopamine + 2 L-ascorbate + O2 = (R)-noradrenaline + H2O + 2 monodehydro-L-ascorbate radical Binds 2 copper ions per subunit. Optimum pH is 5.2. Catecholamine biosynthesis; (R)-noradrenaline biosynthesis; (R)-noradrenaline from dopamine: step 1/1. Homotetramer; composed of two disulfide-linked dimers. Activity is enhanced by nerve growth factor (in superior cervical ganglia and adrenal medulla). Trans-synaptic stimulation with reserpine, acetylcholine and glucocorticoids. N-glycosylated. Proteolytic cleavage after the membrane-anchor leads to the release of the soluble form. There are two main alleles of DBH: DBH-A with Ala-318 and DBH-B with Ser-318 (PubMed:10490716, PubMed:10391209, PubMed:10391210). The disease is caused by variants affecting the gene represented in this entry. Belongs to the copper type II ascorbate-dependent monooxygenase family. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus. Dopamine beta hydroxylase entry