Regulates Wnt proteins sorting and secretion in a feedback regulatory mechanism. This reciprocal interaction plays a key role in the regulation of expression, subcellular location, binding and organelle-specific association of Wnt proteins (PubMed:34587386). Plays also an important role in establishment of the anterior-posterior body axis formation during development (By similarity). Interacts with WNT3A. Interacts with WNT1, WNT3 and WNT5A (By similarity). Co-localizes with the adaptin AP2A2 at distinct punctae. N-glycosylated. The disease is caused by variants affecting the gene represented in this entry. Belongs to the wntless family.