Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. 'Anaerobic' isozyme of acetyl-coenzyme A synthetase, which is required for growth on fermentable carbon sources such as glucose. May be involved in the PDH (pyruvate dehydrogenase complex) bypass. acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate Carbohydrate metabolism; pyruvate metabolism. Predominantly nuclear. Present with 225000 molecules/cell in log phase SD medium. Belongs to the ATP-dependent AMP-binding enzyme family.