Has ribonuclease activity (in vitro). Seems to lack angiogenic activity. Divalent metal ions, such as Cu2+ and Zn2+, may inhibit the ribonucleolytic activity. Homodimer. Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA (By similarity). Expressed (at protein level) in macrophages. Belongs to the pancreatic ribonuclease family.