Broad-specificity transporter of purine and pyrimidine nucleosides (PubMed:374403, PubMed:15678184, PubMed:3311747, PubMed:11466294, PubMed:15513740). Can transport adenosine, uridine, thymidine, cytidine, deoxycytidine, guanosine and inosine (PubMed:374403, PubMed:15678184, PubMed:3311747, PubMed:11466294, PubMed:15513740). Can also transport xanthosine, but with a very low affinity (PubMed:11466294). Transport is driven by a proton motive force (PubMed:374403, PubMed:15513740). adenosine(in) + H(+)(in) = adenosine(out) + H(+)(out) H(+)(in) + uridine(in) = H(+)(out) + uridine(out) H(+)(in) + thymidine(in) = H(+)(out) + thymidine(out) cytidine(in) + H(+)(in) = cytidine(out) + H(+)(out) 2'-deoxycytidine(in) + H(+)(in) = 2'-deoxycytidine(out) + H(+)(out) guanosine(in) + H(+)(in) = guanosine(out) + H(+)(out) H(+)(in) + inosine(in) = H(+)(out) + inosine(out) Inhibited by the protonophore uncouplers 2,4-dinitrophenol and carbonyl cyanide m-chlorophenylhydrazone (CCCP), and by valinomycin (PubMed:15513740, PubMed:374403). Inhibited by the nucleoside antibiotic showdomycin (PubMed:374403). Transcriptionally regulated by CytR and DeoR. Binding of nucleosides to NupG requires the presence of hydroxyl groups at each of the C-3' and C-5' positions of ribose. Belongs to the major facilitator superfamily. Nucleoside:H(+) symporter (NHS) (TC 2.A.1.10) family. Extended N-terminus.