Can metabolize asymmetric dimethylarginine (ADMA) via transamination to alpha-keto-delta-(NN-dimethylguanidino) valeric acid (DMGV). ADMA is a potent inhibitor of nitric-oxide (NO) synthase, and this activity provides mechanism through which the kidney regulates blood pressure. glyoxylate + L-alanine = glycine + pyruvate (R)-3-amino-2-methylpropanoate + pyruvate = 2-methyl-3-oxopropanoate + L-alanine Homotetramer. Knockout mice are hypertensive. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.