Orphan G-protein coupled receptor that regulates cilia length and structure in the Kupffer's vesicle leading to the left-right asymmetry development by establishing a directional fluid flow. Expressed ubiquitously during early stages of development. From bud stage onwards, the expression pattern becomes restricted to the axial structures and the developing Kupffer's vesicle. Morpholino knockdown of the protein leads to defective left-right (LR) axis formation in the embryo. Cilia number and length are reduced in the Kupffer's vesicle (KV). Morpholino knockdown of the protein in Kupffer's vesicle alone is still able to generate the phenotype, indicating that Gpr22 regulates LR asymmetry through the KV. Belongs to the G-protein coupled receptor 1 family.