Involved in skeletal muscle development and maintenance. Expression is predominantly seen in striated muscles, and strong expression in heart and skeletal muscles is observed throughout development to at least 5 dpf. Knockdown of klhl41b result in reduced disorganized muscle without any other significant abnormalities. Knockdown of both genes (klhl41a and klhl41b) is lethal by 3 dpf. Double knockdown fish exhibit severely disorganized muscle compared to controls and either of the single knockdowns.