Paralytic toxin that inhibits insect voltage-gated sodium (Nav) and calcium (Cav) channels in P.americana (American cockroach) dorsal unpaired median (DUM) neurons, and inhibits the B.germanica (German cockroach) Nav channel (BgNaV1) (PubMed:28475112). Also shows a delay in fast inactivation when tested on BgNaV1 (PubMed:28475112). May act as a gating-modifier toxin on Nav and as a pore blocker on Cav (PubMed:28475112). In vivo, reversibly paralyzes both L.cuprina (Australian sheep blowfly) and M.domestica (housefly), but does not affect larvae of H.armigera (cotton bollworms) (PubMed:28475112). Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. PD(50) is 5.8+-0.5 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 30 minutes post-injection). PD(50) is 5.9+-0.4 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 1 hour post-injection). PD(50) is 8.5+-0.9 nmol/g when intra-thoracically injected into L.cuprina blowflies (at 2 hours post-injection). Possibly exists in two forms, due to cis-trans isomerization of Pro-5 or Pro-22. Belongs to the neurotoxin 10 (Hwtx-1) family. 28 (Jztx-11) subfamily.