Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope (Probable). Required for proper protein transport into the nucleus (PubMed:32275884). Part of the nuclear pore complex (NPC). Copy number variations of NUP188 gene may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning. The disease is caused by variants affecting the gene represented in this entry. Belongs to the Nup188 family. Extended N-terminus.