Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. internalized after activation by endothelins. It is not sure whether phosphorylation is on Ser-434 or Ser-435. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily. N-terminal sequencing (PubMed:9422751) indicates the presence of a signal peptide but an unprocessed form where the signal sequence is not cleaved has also been detected (PubMed:8529649). It is unclear if this exists in vivo.