Virulence factor that suppresses host Toll-like receptor (TLR)-mediated cytokine production upon infection, thereby increasing bacterial burden in the urinary tract and promoting renal tissue damage (PubMed:18327267, PubMed:20886104). Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). Also able to hydrolyze NADP(+), but not other NAD(+)-related molecules (PubMed:29395922). H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide H2O + NADP(+) = ADP-D-ribose 2'-phosphate + H(+) + nicotinamide Interacts with host MYD88 (PubMed:18327267, PubMed:23569230). Interacts with host TLR4 (PubMed:23569230). The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.