Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as DTL/CDT2, BCL6 and PRDM1/BLIMP1. The SCF(FBXO11) complex mediates ubiquitination and degradation of BCL6, thereby playing a role in the germinal center B-cells terminal differentiation toward memory B-cells and plasma cells. The SCF(FBXO11) complex also mediates ubiquitination and degradation of DTL, an important step for the regulation of TGF-beta signaling, cell migration and the timing of the cell-cycle progression and exit. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of p53/TP53. Protein modification; protein ubiquitination. Component of the SCF(FBXO11) complex consisting of CUL1, RBX1, SKP1 and FBXO11. Interacts with p53/TP53, BCL6 and DTL (when not phosphorylated). Interacts with PRMD1. At 9.5 dpc and 10.5 dpc, expression is restricted to developing heart tissue. By 11.5 dpc and 12.5 dpc, detected in liver and subsequently in muscle by 13.5 dpc. At 14.5 dpc, still detected in heart, liver and muscle and also in the developing secondary palate including the nasal, medial and oral epithelia of the palatal shelves. At 15.5 dpc and 16.5 dpc, expressed in lung, kidney, heart, liver, muscle and adrenal gland. At this time, fusion of the palate shelves has occurred, with expression confined to the nasal and oral epithelia. At 17.5 dpc, expression in the lung is confined to bronchial epithelial cells and is evident in bone marrow, skin, tissue macrophages, osteoblasts, kidney, liver and spleen. At 18.5 dpc, expressed in bone marrow, liver, kidney and muscle but decreases in heart and lung. At this time, first detected in the middle ear epithelium. At the newborn stage, expression is strong in the middle ear where it is confined to mucin-secreting cells, as well as persisting in bone marrow, kidney and liver. Middle ear expression persists in postnatal head tissue at 4 and 13 days after birth and has declined by 21 days after birth. In the adult, expression is seen in alveolar macrophages of the lung, glomeruli and collecting tubules of the kidney, midbrain, heart and muscle. Not detected at 8.5 dpc. Expressed from 9.5 dpc throughout development and into adulthood (at protein level).