ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123. Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis. an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate ATP + H2O + leukotriene C4(in) = ADP + H(+) + leukotriene C4(out) + phosphate Glycosylated. Deficient mice spontaneously develop calcification and elastic fiber abnormalities in blood vessels and Bruch's membrane in the eye, whereas no clear changes were seen in the extracellular matrix of the skin. Calcification of blood vessels is most prominent in small arteries in the cortex of the kidney, but in old mice, it occurrs also in other organs and in the aorta and vena cava (PubMed:15888484). Mice have reduced inorganic pyrophosphate (PPi) plasma levels, a strong inhibitor of mineralization (PubMed:24277820). Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.