Participates in tumor necrosis factor-alpha (TNF)-induced cell death (Ref.4). May be a target of Wnt/beta-catenin signaling in the liver (By similarity). Interacts with BRI3BP. Interacts with MGAT1 and IFITM3 (By similarity). Co-localizes with MGAT1 and IFITM3 at the perinuclear region. High expression in cerebral cortex, and in cerebellar cortex. Up-regulated during TNF-mediated inflammation and immunity. Belongs to the BRI3 family.