Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance (PubMed:9348540). May anchor NUP62 and other nucleoporins, but not NUP153 and TPR, to the NPC (PubMed:15229283). Part of the nuclear pore complex (NPC) (PubMed:9348540, PubMed:15229283). Forms a complex with NUP35, NUP93, NUP155 and lamin B (PubMed:15703211, PubMed:26878725). Does not interact with TPR (PubMed:12802065). Localized near the center, on both the cytoplasmic and nuclear side, of the NPC core structure. The disease is caused by variants affecting the gene represented in this entry. Belongs to the NUP186/NUP192/NUP205 family. Extended N-terminus.