Ureolysis may allow urea to be employed as a nitrogen source for growth and produces ammonia which may protect from killing at low pH. 2 H(+) + H2O + urea = CO2 + 2 NH4(+) Urea concentrations in the oral cavity of humans normally range from 3 mM to 10 mM. Optimum pH is 7.0. Optimum temperature is 60 degrees Celsius. Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. By low pH and excess glucose. Belongs to the urease gamma subunit family. Truncated N-terminus.