Plays a role in the establishment of cell polarity and epithelial lumen formation (PubMed:20835237). Also plays an essential role in ciliogenesis and subsequent Hedgehog signaling pathway that requires the presence of intact primary cilia for pathway activation. Mechanistically, interacts with and mediates RABEP2 centrosomal localization which is critical for ciliogenesis (By similarity). Located at the distal ends of both centrioles and colocalizes to centrosomes throughout the cell cycle. Morpholino oligonucleotide-mediated gene knockdown causes multiple developmental defects, including abnormal body axis curvature, shortened and broadened tails, kidney cysts at 72 hours post fertilization and hydrocephalus.