2-oxoglutarate-dependent dioxygenase involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family (PubMed:26359402). Catalyzes the conversion of yatein to deoxypodophyllotoxin (PubMed:26359402). Can also use, to some extent, demethylyatein as substrate (PubMed:26359402). (-)-yatein + 2-oxoglutarate + O2 = (-)-deoxypodophyllotoxin + CO2 + H2O + succinate Binds 1 Fe(2+) ion per subunit. Aromatic compound metabolism; phenylpropanoid biosynthesis. Mostly expressed in leaves and stems. Transiently induced after wounding. Combinatorially expression of Sinopodophyllum hexandrum (mayapple) genes of the podophyllotoxin pathway (e.g. DIR, PLR, SDH, CYP719A23, OMT3, CYP71CU1, OMT1, 2-ODD, CYP71BE54 and CYP82D61) in Nicotiana benthamiana (tobacco) results in the production of the chemotherapeutic compound etoposide. Belongs to the iron/ascorbate-dependent oxidoreductase family.