This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA. Vas deferens, hippocampus, cerebral cortex, aorta, brain stem, heart and spleen. Palmitoylated. Palmitoylation by ZDHHC21 may increase the expression of the receptor and regulate downstream signaling. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily.