DNA-dependent ATPase. May modulate chromosome segregation. ATP + H2O = ADP + H(+) + phosphate Interacts with UBR1 and UBR2. Interacts with MCM10; this interaction regulates RECQL4 unwinding activity. Ubiquitously expressed, with highest levels in thymus and testis. Up-regulated in actively dividing cells. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the helicase family. RecQ subfamily. Truncated N-terminus.