IsCT2 shows weak hemolytic activity and antibacterial activity against both Gram-positive and Gram-negative bacteria probably by forming pores in the cell membrane. IsCT2 adopts an amphipathic alpha-helical structure. IsCT2f shows neither hemolytic, nor antibacterial activities, surely due to the fact that it cannot apply amphipathic alpha-helical structure. Forms a helical membrane channel in the prey. Expressed by the venom gland. IsCT2F is an enzymatic proteolytic cleavage product of IsCT2 by the proteases present in the venom. Belongs to the non-disulfide-bridged peptide (NDBP) superfamily. Short antimicrobial peptide (group 4) family.