Histone methyltransferase that dimethylates Lys-36 of histone H3 (H3K36me2). Transcriptional intermediary factor capable of negatively influencing transcription. May also positively influence transcription. Essential for early post-implantation development. L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-methionine = 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(36)-[histone H3] + 2 S-adenosyl-L-homocysteine Interacts with AR DNA- and ligand-binding domains (By similarity). Interacts with the ligand-binding domains of RARA and THRA in the absence of ligand; in the presence of ligand the interaction is severely disrupted but some binding still occurs. Interacts with the ligand-binding domains of RXRA and ESRRA only in the presence of ligand. Interacts with ZNF496. Expressed in the embryo and the outer region of the uterine decidua at early post-implantation 5.5 dpc stage. Uniformly expressed in embryonic and extraembryonic tissues during gastrulation stage 7.5 dpc. Expressed differentially after stage 14.5 dpc with highest expression in proliferating cells. Enriched in the telencephalic region of the brain, spinal cord, intestinal crypt, tooth buds, thymus and salivary glands at stage 16.5 dpc. Also expressed in the ossification region of developing bones and in the periosteum. Contains 2 adjacent but distinct nuclear receptor interaction domains (NID+L and NID-L) to which nuclear receptors bind differentially in the presence and absence of ligand respectively. Belongs to the class V-like SAM-binding methyltransferase superfamily.