Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. By interferon type I, type II and LPS. Induced by infection with spring viremia of carp virus, presumably through type I interferon pathway. Belongs to the radical SAM superfamily. RSAD2 family.