Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:7586133). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:7586133). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (By similarity). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:7586133). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:7586133, PubMed:30304478, PubMed:32144205). 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+) 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+) 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+) 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+) H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP Binds 2 Mg(2+) ion per subunit. Monomer. Expressed in liver in hepatocytes and weakly in Kupffer's cells. Expression detected in testes in primary and secondary spermatocytes and interstitial cells. High expression levels detected in the inner cortex of kidney, with lower levels detected in the tubules of the outer cortex, medulla, renal pelvis and glomeruli (at protein level). Expressed in heart, brain, spleen, lung, liver, skeletal muscle, kidney and testis. Belongs to the Nudix hydrolase family.