Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes, such as CCND1, and may thereby act as tumor suppressor (By similarity). May be involved in dendritic cell and neuron differentiation. In neurons, seems to concentrate at axonal growth cone. Broadly expressed, with highest levels in heart, liver, skeletal muscle and aorta. Up-regulated by aldosterone in kidney and colon, but not in heart. Down-regulated in cortex by antidepressant treatments. Belongs to the NDRG family.