Cytochrome P450 involved in the biosynthesis of etoposide, a chemotherapeutic compound of the topoisomerase inhibitor family (PubMed:23161544, PubMed:26359402). Catalyzes the conversion of matairesinol to pluviatolide (PubMed:23161544, PubMed:26359402). (-)-matairesinol + O2 + reduced [NADPH--hemoprotein reductase] = (-)-pluviatolide + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] kcat is 14.9 min(-1) with (-)-matairesinol as substrate. Aromatic compound metabolism; phenylpropanoid biosynthesis. Expressed in leaves, rhizomes and stems. Transiently induced after wounding. Combinatorially expression of Sinopodophyllum hexandrum (mayapple) genes of the podophyllotoxin pathway (e.g. DIR, PLR, SDH, CYP719A23, OMT3, CYP71CU1, OMT1, 2-ODD, CYP71BE54 and CYP82D61) in Nicotiana benthamiana (tobacco) results in the production of the chemotherapeutic compound etoposide. Belongs to the cytochrome P450 family.