Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:30304478, PubMed:32144205, PubMed:29281266). Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (By similarity). Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:30304478, PubMed:32144205, PubMed:29281266). Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:30304478, PubMed:32144205, PubMed:29281266). Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205). Through this antimutagenic activity protects cells from oxidative stress (PubMed:30304478, PubMed:32144205, PubMed:29281266). 2-oxo-dATP + H2O = 2-oxo-dAMP + diphosphate + H(+) 2-oxo-ATP + H2O = 2-oxo-AMP + diphosphate + H(+) 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+) 8-oxo-dATP + H2O = 8-oxo-dAMP + diphosphate + H(+) H2O + O(6)-methyl-dGTP = diphosphate + H(+) + O(6)-methyl-dGMP H2O + N(6)-methyl-dATP = diphosphate + H(+) + N(6)-methyl-dAMP H2O + N(6)-methyl-ATP = diphosphate + H(+) + N(6)-methyl-AMP Binds 2 Mg(2+) ion per subunit. Monomer. Belongs to the Nudix hydrolase family.