Protects dopaminergic neurons against oxidative stress-induced neurodegeneration (PubMed:25474638, PubMed:29346364). May act partly via dopamine receptor dop-2 to negatively regulate dopamine reuptake transporter dat-1 activity (PubMed:25474638). Also plays a role in modulating behaviors linked to dopamine signaling (PubMed:25474638). Confers protection against oxidative stress in the whole body (PubMed:29346364). May localize near the nucleus or ER. Expressed in dopaminergic neurons, head muscles, vulva and spermatheca. In larvae, expressed in the NSM serotonergic neuron and in muscles. Belongs to the tetraspanin (TM4SF) family.