Catalyzes the F420H(2)-dependent reduction of biliverdin-IXalpha at C10 position, leading to bilirubin-IXalpha, a potent antioxidant. As biliverdin-IXalpha is produced in high amounts in macrophages infected with M.tuberculosis, its reduction by Rv2074 may play a role in protecting mycobacteria against oxidative stress, aiding the persistence of M.tuberculosis infection. bilirubin IXalpha + H(+) + oxidized coenzyme F420-(gamma-L-Glu)(n) = biliverdin IXalpha + reduced coenzyme F420-(gamma-L-Glu)(n) kcat is 0.072 sec(-1). Homodimer. Belongs to the F420H(2)-dependent biliverdin reductase family. Was originally thought to be an FMN-dependent pyridoxine 5'-phosphate oxidase.