Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease possesses deubiquitinating and deneddylating activities (By similarity). Impairs ubiquitination and degradation of NF-kappa-B inhibitor alpha (NFKBIA), thereby preventing NF-kappa-B activation. Binds to host NFKBIA. Secreted, and delivered into the host cell. Located predominantly on the plasma membrane and to a lesser extent on intracellular membranes, especially the host cell nuclear envelope. Expressed late in the infectious cycle. Belongs to the peptidase C48 family.