Interacts with clathrin light chain A and stimulates clathrin self-assembly and clathrin-mediated endocytosis. Interacts with CLTA. Expressed exclusively in neurons (at protein level). In all age groups, expressed at significantly higher levels in the medial prefrontal and orbital frontal cortices of spontaneously hypertensive rats (SHR), a model of attention deficit-hyperactivity disorder, than Wistar Kyoto (WKY) animals. In the motor cortex, dorsal striatum and nucleus accumbens, expression is significantly elevated in SHR only in younger animals. Levels decrease significantly with age. Belongs to the NSG family. The human ortholog was originally thought to interact with the D1 dopamine receptor (DRD1) and to play a role in potentiating calcium ion-dependent signaling but this work was later retracted.