Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network. Signaling adapter which plays a role in neuronal differentiation. Involved in regulation of NGF-dependent neurite outgrowth (By similarity). May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (PubMed:22404429). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK. Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway (By similarity). Associated component of the adapter-like complex 4 (AP-4) (By similarity). Interacts with IKBKG and TRAF6 (By similarity). Interacts with F-actin, acetylated actin, TUBB3, STX1A, KIF5B and KLC1 (PubMed:22404429). Translocated to the nuclear envelope upon stimulation with NGF (By similarity). Associated with membranes and microtubules (PubMed:22404429). Expressed in brain, brain stem and spinal cord (at protein level). Expressed at 15 dpc in hippocampal, cortical and cerebellar brain, and brain stem and spinal cord. At 18 dpc, expression strongly overlaps with TUBB3 expression in post-mitotic neurons throughout the entire brain. Expression levels increase to 18 dpc/P1 after which the levels decline in the hippocampus, cerebellum and brain stem and spinal cord into adulthood while remaining high in the cortex. The RUN domain is necessary for NGF induced nuclear redistribution. Phosphorylated on serine residues following nuclear translocation. Polyubiquitinated; polyubiquitination involves TRAF6. Truncated C-terminus.