Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Mediates susceptibility to Turnipmosaic potyvirus (TuMV) and Tobacco etch potyvirus (TEV). EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G. EIF4E is also known to interact with other partners. In higher plants two isoforms of EIF4F have been identified, named isoform EIF4F and isoform EIF(iso)4F. Isoform EIF4F has subunits p220 and p26, whereas isoform EIF(iso)4F has subunits p82 and p28. This isoform interacts with the viral protein genome linked (VPg)-proteinase of turnip mosaic potyvirus. Interacts directly with LOX2. Interacts with BTF3 (PubMed:15716105). Abundant in floral organs and in young developing tissues. According to the redox status, the Cys-97-Cys-138 disulfide bridge may have a role in regulating protein function by affecting its ability to bind capped mRNA. Decreased susceptibility to TuMV and TEV. Belongs to the eukaryotic initiation factor 4E family. Extended N-terminus.