Translational repressor involved in the negative regulation of immune receptor accumulation via the inhibition of nucleotide-binding leucine-rich repeat (NLR) receptor mediated defense (PubMed:28362261). Represses NLR protein accumulation (e.g. SNC1, RPS4, RPM1 and RPS2) (PubMed:28362261). Together with SMG7, helps to restrict effector-triggered immunity (ETI) cell death induction during pathogen infection in a salicylic acid- (SA) and reactive oxygen species- (ROS) independent manner (PubMed:29073135). Required for pathogen-associated molecular pattern (PAMP)-induced suppression of necrotrophic fungal (e.g. F.moniliforme) pathogen-derived mycotoxin-triggered (e.g. fumonisin B1) cell death (PubMed:29073135). (Microbial infection) Required for early steps of plantago asiatica mosaic virus (PlAMV, genus Potexvirus) infection (PubMed:27402258). Facilitates pathogenic growth of avirulent hemi-biotrophic bacteria P.syringae pv. tomato (Pst) DC3000 (e.g. AvrRps4 and AvrRpm1) and of the compatible oomycete H.arabidopsidis Noco2 (PubMed:28362261, PubMed:29073135). Associates with eIF4E initiation factors and the ribosome complex, thus likely contributing to the proper translation of target proteins (PubMed:28362261). Interacts directly with RPL18B and eIF4E1 (PubMed:28362261). Binds to SMG7 (PubMed:29073135). Expressed in all tissues, mostly in flowers, leaves and stems, and, to a lower extent, in roots (at protein level). Quickly phosphorylated at Ser-39 after treatment of seedlings with the pathogen-associated molecular pattern (PAMP) flg22. Reduced size with a curly leaf phenotype associated with an abnormal constitutive PR1 expression (PubMed:28362261, PubMed:29073135). No spontaneous lesions, but enhanced cell death independent of salicylic acid (SA) biosynthesis or reactive oxygen species (ROS) production during pathogen infection (e.g. P.syringae and F.moniliforme) (PubMed:29073135). Heightened nucleotide-binding leucine-rich repeat protein (NLR, e.g. SNC1, RPS4, RPM1 and RPS2) accumulation and enhanced resistance against virulent pathogens (PubMed:28362261). Enhanced snc1-mediated autoimmunity including stunted growth, increased expression of pathogenesis related (PR, e.g. PR1 and PR2) genes and enhanced disease resistance against the virulent oomycete pathogen H.arabidopsidis Noco2, and reduced hemi-biotrophic bacterial growth of P.syringae pv. tomato (Pst) DC3000 expressing avirulent effectors AvrRps4 and AvrRpm1 (PubMed:28362261, PubMed:29073135). Abnormal resistance to plantago asiatica mosaic virus (PlAMV, genus Potexvirus) with the absence of infection foci prior to cell-to-cell movement (PubMed:27402258). Increased oxidative bursts, mitogen-activated protein kinase activation and callose deposition in response to the pathogen-associated molecular pattern (PAMP) flg22 (PubMed:29073135).