Transcriptional regulator which controls the expression of hepatic genes during the transition of endodermal cells to hepatic progenitor cells, facilitating the recruitment of RNA pol II to the promoters of target genes (PubMed:30597922). Activates the transcription of CYP2C38 (By similarity). Represses the CLOCK-ARNTL/BMAL1 transcriptional activity and is essential for circadian rhythm maintenance and period regulation in the liver and colon cells (PubMed:30530698). Homodimerization is required for HNF4-alpha to bind to its recognition site (PubMed:14982928). Interacts with CLOCK, ARNTL, CRY1, CRY2, PER1 and PER2 (PubMed:30530698). Interacts with NR0B2/SHP; the resulting heterodimer is transcriptionnally inactive (PubMed:28128295). Interacts with DDX3X; this interaction disrupts the interaction between HNF4 and NR0B2 that forms inactive heterodimers and enhances the formation of active HNF4 homodimers (PubMed:28128295). Additional isoforms seem to exist. The 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. Phosphorylated on tyrosine residue(s); phosphorylation is important for its DNA-binding activity. Phosphorylation may directly or indirectly play a regulatory role in the subnuclear distribution. Phosphorylation at Ser-313 by AMPK reduces the ability to form homodimers and bind DNA. Acetylation at Lys-458 lowers transcriptional activation by about two-fold. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility may be associated with variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Binds fatty acids. Produced by alternative promoter usage. Produced by alternative splicing of isoform HNF4-Alpha-1. Produced by alternative splicing of isoform HNF4-Alpha-1. Produced by alternative splicing of isoform HNF4-Alpha-1. Produced by alternative promoter usage. Produced by alternative splicing of isoform HNF4-Alpha-7. Produced by alternative splicing of isoform HNF4-Alpha-7. Belongs to the nuclear hormone receptor family. NR2 subfamily. Truncated N-terminus. Hepatocyte nuclear factors entry