Component of the post-replicative DNA mismatch repair system (MMR). Forms the heterodimer MutS alpha (MSH2-MSH6 heterodimer) which binds to DNA mismatches thereby initiating DNA repair. MutS alpha recognizes single base mismatches and trinucleotide insertion-deletion loops (IDL) in the DNA. Is involved in a UV-B-induced DNA damage response pathway. Heterodimer consisting of MSH2-MSH6 (MutS alpha). A number of isoforms are produced. According to EST sequences. By UV-B. Belongs to the DNA mismatch repair MutS family.