Transcription factor that modulates cell fate reprogramming from the somatic state to the pluripotent and neuronal fate (PubMed:31519808). Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase (By similarity). In liver, controls the expression of hormone-regulated gluconeogenic genes such as G6PC1 and PCK1. This regulation is independent of the insulin receptor activation (PubMed:34914893). In liver, recruited to target gene promoters following treatment with dexamethasone and cAMP. Binding is decreased in presence of insulin. Component of the PTW/PP1 phosphatase complex, composed of PPP1R10/PNUTS, TOX4, WDR82 and PPP1CA or PPP1CB or PPP1CC. Interacts with PPP1R10/PNUTS (By similarity). Interacts with FOXO1 and CREB1 (increased by cAMP); FOXO1 and CREB1 are required for full induction of TOX4-dependent activity and the interactions are inhibited by insulin (PubMed:34914893). Associated with chromatin. In liver, expression is increased upon high fat diet. Conditional knockout in liver lead to no 10% reduction of glucose levels after 4 h fasting with an improvement of glucose tolerance and an increased insulin sensitivity.