Secreted effector that induces necrotic lesions in Nicotiana benthamiana (PubMed:22352720). Interacts with the host receptor-like kinases (RLKs) BAK1/SERK3 and BKK1/SERK4, inhibits their kinase activity and suppresses INF1-induced pathogen-associated molecular pattern (PAMP)-triggered immunity (PTI) in N.benthamiana (PubMed:30584105). Also interacts with the host receptor-like cytoplasmic kinase (RLCK) BIK1 and inhibits its kinase activity, thereby inhibiting PAMP-induced ROS generation (PubMed:30584105). In PTI, phosphorylation relaying by RLKs and RLCKs is critical for the initiation of downstream signaling (PubMed:30584105). Interacts with the host pattern recognition receptor (PRR)-associated kinases BAK1/SERK3, BKK1/SERK4 and BIK1. Secreted, via the endoplasmic reticulum-to-Golgi route and subsequent exocytosis, and accumulates in a ring-like region around the neck of the biotrophic primary hyphae at the pathogen-plant interface. Preferentially expressed in biotrophic invasive hyphae at the post-invasive stage. The C-terminal region from residues 103 to 132 is important for BAK1/SERK3-binding and the host cell death suppression. Belongs to the NIS1 effector family.