Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. Interacts with FEM1A. Highly expressed in intestine, duodenal epithelium, uterus, thymus and adrenal cortex. Lower but significant expression in whole adrenal, lung, spleen, stomach, and kidney. In this latter organ, the receptor is localized in the glomeruli and the transitional epithelium of the renal calyx. Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention. Belongs to the G-protein coupled receptor 1 family.