Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells (PubMed:20114026). Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells (PubMed:26749446). Forms an heterotetramer with Tsi2 consisting of two Tse2 dimers and two Tsi2 dimers. Formation of the complex inactivates Tse2 enzymatic activity. Delivered to the target cell cytoplasm by the H1 type VI (H1-T6SS) secretion system.