UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens (epitestosterone, androsterone) and estrogens (estradiol, epiestradiol, estriol,catechol estrogens). Also regulates the levels of retinoic acid, a major metabolite of vitamin A involved in apoptosis, cellular growth and differentiation, and embryonic development. Contributes to bile acid (BA) detoxification by catalyzing the glucuronidation of BA substrates, which are natural detergents for dietary lipids absorption. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist losartan, caderastan and zolarsatan, drugs which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent. glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor beta-D-glucuronoside + H(+) + UDP 17alpha-estradiol + UDP-alpha-D-glucuronate = 17alpha-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP 17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 17-O-(beta-D-glucuronate) + H(+) + UDP 2-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 2-hydroxy-17beta-estradiol 3-O-(beta-D-glucuronate) + H(+) + UDP 4-hydroxy-17beta-estradiol + UDP-alpha-D-glucuronate = 17beta-estradiol 4-O-(beta-D-glucuronate) + H(+) + UDP 4-hydroxyestrone + UDP-alpha-D-glucuronate = estrone 4-O-(beta-D-glucuronate) + H(+) + UDP 16alpha-hydroxyestrone + UDP-alpha-D-glucuronate = 16alpha-hydroxyestrone 16-O-(beta-D-glucuronate) + H(+) + UDP 16alpha,17beta-estriol + UDP-alpha-D-glucuronate = 16alpha,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP 16beta,17beta-estriol + UDP-alpha-D-glucuronate = 16beta,17beta-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 16-O-(beta-D-glucuronate) + H(+) + UDP 16alpha,17alpha-estriol + UDP-alpha-D-glucuronate = 16alpha,17alpha-estriol 17-O-(beta-D-glucuronate) + H(+) + UDP epitestosterone + UDP-alpha-D-glucuronate = epitestosterone 17-O-(beta-D-glucuronate) + H(+) + UDP hyodeoxycholate + UDP-alpha-D-glucuronate = H(+) + hyodeoxycholate 6-O-(beta-D-glucuronate) + UDP hyocholate + UDP-alpha-D-glucuronate = H(+) + hyocholate 6-O-(beta-D-glucuronate) + UDP all-trans-retinoate + UDP-alpha-D-glucuronate = all-trans-retinoyl-1-O-(beta-D-glucuronate) + UDP all-trans-4-hydroxyretinoate + UDP-alpha-D-glucuronate = 4-hydroxy-4-O-(beta-D-glucuronide)-all-trans-retinoate + H(+) + UDP mycophenolate + UDP-alpha-D-glucuronate = mycophenolic acid O-acyl-beta-D-glucuronide + UDP losartan + UDP-alpha-D-glucuronate = losartan-2-N-beta-D-glucuronide + UDP candesartan + UDP-alpha-D-glucuronate = candesartan O-beta-D-glucuronoside + UDP candesartan + UDP-alpha-D-glucuronate = candesartan-2-N-beta-D-glucuronide + UDP UDP-alpha-D-glucuronate + zolasartan = UDP + zolarsartan O-beta-D-glucuronoside Belongs to the UDP-glycosyltransferase family.