Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Involved in anthocyanin biosynthesis (By similarity). Polyketide binding proteins (PBP) which promotes the catalytic activities of CHS_H1 and PT1L and triggers demethylxanthohumol (DMX) production (PubMed:29760092). a chalcone = a flavanone. Secondary metabolite biosynthesis; flavonoid biosynthesis. Component an active demethylxanthohumol (DMX) biosynthetic metabolon in glandular trichomes (lupulin glands) that encompasses a chalcone synthase (CHS) and a membrane-bound prenyltransferase (PubMed:29760092). Interacts with CHS_H1 and PT1L (PubMed:29760092). Mostly expressed in glandular trichomes (lupulin glands), and, to a lower extent, in cones, cones bracts, leaves, stems and roots. Belongs to the chalcone isomerase family.