Palmitoyl acyltransferase that mediates palmitoylation of proteins such as PLN and ZDHHC6 (By similarity). Required during embryonic heart development and cardiac function, possibly by mediating palmitoylation of PLN, thereby affecting PLN phosphorylation and homooligomerization (By similarity). Also required for eye development (By similarity). Palmitoylates ZDHHC6, affecting the quaternary assembly of ZDHHC6, its localization, stability and function (By similarity). May play a role in DNA damage response (By similarity). May be involved in apoptosis regulation (By similarity). Involved in the proliferation of neural stem cells by regulating the FGF/ERK pathway (By similarity). hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] Interacts with ABL1 (By similarity). Interacts with COPS5/JAB1 (By similarity). The DHHC domain is required for palmitoyltransferase activity. Belongs to the DHHC palmitoyltransferase family.