Alkylsulfatase that cleaves both short and medium-length alkylsulfates, including the widely used detergent sodium dodecyl sulfate (SDS) (PubMed:16684886). Acts in vitro on primary alkylsulfates such as decyl sulfate, octyl sulfate and hexyl sulfate, but not on sulfated sugars and arylsulfates (PubMed:16684886, PubMed:23061549). The hydrolysis of SDS allows the bacterium to use SDS as a sole carbon or sulfur source (PubMed:16684886). In addition, contributes to the in vivo virulence of P.aeruginosa by playing a central role in the degradation of mucin, a glycoprotein that is the primary component of the mucus overlaying the host epithelial tissues (PubMed:31907968). Plays a role in the degradation of both protein and carbohydrate moieties in mucin via the release of sulfate from mucin, D-galactose 6-sulfate (Gal-6S) and N-acetyl-D-glucosamine 6-sulfate (GlcNAc-6S) (PubMed:31907968). a primary linear alkyl sulfate ester + H2O = a primary alcohol + H(+) + sulfate Binds 2 Zn(2+) ions per subunit. kcat is 337 min(-1) with 1-octyl sulfate as substrate. kcat is 5.4 min(-1) with (R)-2-octyl sulfate as substrate. Homodimer. Up-regulated in mucin minimal medium. Contains three distinct domains: an N-terminal catalytic domain that contains a binuclear Zn(2+) cluster, a central dimerization domain that ensures resistance to high concentrations of SDS and a C-terminal domain that provides a hydrophobic groove, presumably to recruit long aliphatic substrates (PubMed:16684886). Although separated by the dimerization domain in terms of sequence, the N-terminal and C-terminal domains are spatially directly adjacent (PubMed:16684886). Insertion mutant cannot grow with SDS as a sole carbon and/or sulfur source (PubMed:16684886). Disruption of the gene leads to a decrease in the growth in mucin minimal medium and a reduction in the degradation of both carbohydrate and protein moieties in mucin (PubMed:31907968). Mutant shows reduced swimming, swarming and twitching motilities and decreased mucin gel penetration ability (PubMed:31907968). Virulence of the mutant is attenuated in leukopenic mice compared with the wild-type strain (PubMed:31907968). Belongs to the metallo-beta-lactamase superfamily. Type III sulfatase family.