Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta-catenin. Interacts with CTNNB1 (By similarity). Interacts with KATNB1. Also interacts with gamma-tubulin and KIF23. Preferentially localized to the mother centriole. Also localized to the midbody in cells undergoing cytokinesis. Within neurons, enriched in cell bodies and localized to branch points and the tips of axonal branches. Belongs to the LZTS2 family.