Solute transporter for tetraethylammonium (TEA), cimetidine, choline, procainamide, cimetidine, quinidine, guanidine, N-methylnicotinamide (NMN). Responsible for the secretion of cationic drugs across the brush border membranes. Optimum pH is 8.5. Active from pH 6 to 8.5. Localized to the plasma membrane and to the intracellular organelles. Expressed in testis; especially in testicular Leydig cells. Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.