Promotes growth of cell projections in oligodendrocyte precursors. Responsible for degradative ubiquitination of the WNK kinases WNK1, WNK3 and WNK4 (By similarity). Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, such as NPTXR, leading most often to their proteasomal degradation. Plays a role in the reorganization of the actin cytoskeleton. Binds actin. Interacts with KLHL12. Interacts (via N-terminus) with FYN (via SH3 domain) (By similarity). Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. Interacts with NPTXR and CUL3. A proportion colocalizes with the actin cytoskeleton (By similarity). When over-expressed, colocalizes with NPTXR in perinuclear aggresomes. Truncated N-terminus.