Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Cannot use acetyl-CoA as substrate. fluoroacetyl-CoA + H2O = CoA + fluoroacetate + H(+) kcat is 390 sec(-1) with fluoroacetyl-CoA as substrate and 0.06 sec(-1) with acetyl-CoA (at pH 7.6 and 25 degrees Celsius, PubMed:20836570). kcat is 0.044 sec(-1) with fluoroacetyl-CoA as substrate (PubMed:20430898). Homodimer.