Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with SKP1 and CUL1 (By similarity). Expressed in brain, liver, pancreas and adipose tissue (at protein level). Widely expressed. Strong expression in embryos. Maximally expressed in brain during embryonic development but declined thereafter.