PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be involved during embryogenesis and organ development by regulating the folding of EMB30/GNOM, and thus, by modulating its activity. [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Interacts with EMB30/GNOM. Mostly cytoplasmic, also membrane-associated (PubMed:10715321). Present in endoplasmic reticulum and barely secreted (PubMed:10189705). Ubiquitous, mostly in aerial organs (at protein level). Mostly expressed in both apical and basal regions in peduncles and stems (including upper roots) before the bolting stage. Later restricted in the apical region. During embryogenesis, accumulates in all cells during globular stage. From the heart stage, more expressed in inner cells than in epidermal cells (at protein level). Up-regulated by cold, salt and cytokinin treatment. Belongs to the cyclophilin-type PPIase family.