Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Exists in an autoinhibited state in the absence of substrate protein, due to interactions of the leucine-rich repeat domain with the catalytic domain. Is activated upon binding to a substrate protein. Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. The LRR (leucine-rich repeat) domain is involved in autoinhibition of the enzyme activity by interacting with the catalytic domain. Ubiquitinated in the presence of host E1 ubiquitin-activating enzyme UBA1, E2 ubiquitin-conjugating enzyme UBE2D2 and ubiquitin. Belongs to the LRR-containing bacterial E3 ligase family.