Host-defense peptide that has antimicrobial activity against Gram-positive and Gram-negative bacteria and fungi (in vitro) (PubMed:2543629). Exhibits activity against E.coli, A.calcoaceticus, S,aureus and C.albicans (PubMed:2543629). Expressed in neutrophils (at protein level) (PubMed:2543629). Highest expression in bone marrow and to a much lesser extent in small intestine (PubMed:7594610). Belongs to the alpha-defensin family.