Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. Neuroendocrine and endocrine secretory granules. Expressed in the adrenal medulla, and in pheochromocytoma. Not expressed in liver. Extensively processed by limited proteolysis at conserved basic residues. Alternative processing are seen in different tissues (By similarity). O-glycosylated. Belongs to the chromogranin/secretogranin protein family. Extended N-terminus.