May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and turnover. Binds to TRIO and F-actin (PubMed:11148140). May also interact with myosin II (PubMed:11148140). Interacts with HECTD3 (PubMed:18194665). Interacts with PJVK (By similarity). Localized to F-actin in a periodic pattern. Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to anaphase. At telophase, relocalizes to midbody. Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain, retina and cochlea but is not detectable in the other tissues. Contains at least 2 actin-binding sites per coiled-coil dimer. Ubiquitinated by HECTD3, leading to its degradation by the proteasome. Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome segregation. The disease is caused by variants affecting the gene represented in this entry. Has been identified by a selection system for genes encoding nuclear-targeted protein.