Plays a role in the regulation of microglia polarization. Highly expressed in brain, in regions such as the hippocampus, the habenular, thalamic nuclei and hypophysial pars tuberalis (PubMed:25595455). Expression levels in the hypophysial pars tuberalis vary between day and night: they are low at mid-day and high at mid-night. The expression in the other regions do not display a day/night difference (PubMed:22426341). By ischemia. Up-regulated in the microglia in the middle cerebral artery occlusion (MCAO), expression reduced back to control level at 14 days after MCAO. Belongs to the TAFA family.