Nuclear receptor coactivator. May play a role in signal transduction. Interacts with many nuclear receptors including AR, ESR1, ESRRA, ESRRG, NR3C1/GR, NR5A1, PGR, TR, RAR and RXR. Interacts with GRB2. Expressed in liver, lung, fat and NK/T cells. The interaction between PNRC1 and nuclear receptors is dependent on the SH3 binding motif. Belongs to the PNRC family. PNRC1 subfamily.