Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury. Interacts with RTN4, UQCRC1 and UQCRC2. Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.