Membrane G-protein coupled estrogen receptor that binds to 17-beta-estradiol (E2) with high affinity, leading to rapid and transient activation of numerous intracellular signaling pathways. Plays a role in the embryonic development of sensory and motor neurons. May induce apoptosis and reduce proliferation of brain cells. Involved in maintenance of meiotic arrest in oocytes. Binds 17-beta-estradiol (E2) in plasma membranes with high affinity and displays rapid kinetics of association and dissociation. Homodimer. Heterodimer (By similarity). Colocalized with cadherin at the plasma membrane. Expressed in oocytes (at protein level). Highly expressed in brain, heart, testis and ovary. Weakly expressed in muscle and intestine. Expressed during oocyte development. Belongs to the G-protein coupled receptor 1 family.