Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Negatively regulates cilium formation and structure (PubMed:23807208). Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer. Heterotetramer of 2 NUBP1 and 2 NUBP2 chains (By similarity). Interacts with KIFC1 (PubMed:16638812). Interacts with NUBP1 (PubMed:16638812, PubMed:23807208). Enriched at the centrosomes during mitosis (By similarity). Enriched in centrioles of microtubule asters during prophase, prometaphase and telophase stages of mitosis (PubMed:23807208). Localized at centrioles and in the nucleus at interphase (PubMed:23807208). Colocalizes with nubp-1 at prometaphase (PubMed:23807208). Widely expressed. Expressed at 7, 11, 15 and 17 dpc. Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.