Extracellular signal peptide that regulates cell fate. May act with CLV1 as a ligand-receptor pair in a signal transduction pathway, coordinating growth between adjacent meristematic regions. Interacts with the extracellular leucine-rich repeat region of CLV1. Mostly expressed in roots and seedlings, and, to a lower extent, in apex. The O-glycosylation (arabinosylation) of the hydroxyproline Pro-70 enhances binding affinity of the CLE2p peptide for its receptor. Belongs to the CLV3/ESR signal peptide family.