PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins (By similarity). PKC also serves as the receptor for phorbol esters, a class of tumor promoters (By similarity). Acts in a hh-signaling pathway which regulates the Duox-dependent gut immune response to bacterial uracil; required for the activation of Cad99C and consequently Cad99C-dependent endosome formation, which is essential for the Duox-dependent production of reactive oxygen species (ROS) in response to intestinal bacterial infection (PubMed:25639794). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Binds 3 Ca(2+) ions per C2 domain. Head neural tissue. Up-regulated in the midgut epithelium in response to bacterial uracil. This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme. The sequence shown is that of Oregon-R. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.