Probable ATP-binding RNA helicase (Probable). Involved in pre-mRNA splicing as component of the spliceosome (PubMed:29301961, PubMed:9524131). ATP + H2O = ADP + H(+) + phosphate Identified in the spliceosome C complex. The disease is caused by variants affecting the gene represented in this entry. Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily. Extended N-terminus.