Catalyzes the carbon-carbon bond cleavage of the bicyclic beta-diketone 6-oxocamphor via a retro-Claisen reaction to yield the optically active (2R,4S)-beta-campholinic acid. It is also able to cleave 2,2-disubstituted cyclohexa-1,3-diones such as 2-methyl-2-propylcyclohexa-1,3-dione and 2-methyl-2-butylcyclohexa-1,3-dione which result in racemic keto acid products. Transformations of the bicyclic diketone substrates bicyclo[2.2.1]heptane 2,6-dione and bicyclo[2.2.2]octane-2,6-dione yield (S)-keto acid products. bornane-2,6-dione + H2O = [(1S)-4-hydroxy-2,2,3-trimethylcyclopent-3-enyl]acetate + H(+) Inhibited by copper and mercury ions. Also inhibited by thiol active reagents, such as N-ethylmaleimide and hydroxymercuribenzoate. EDTA has a slight activating effect. kcat is 167 sec(-1) with 6-oxocamphor. Optimum pH is 7. Hexamer. Dimer of trimers. Belongs to the enoyl-CoA hydratase/isomerase family.