Phosphatidylserine receptor that plays an important functional role in regulatory B-cells homeostasis including generation, expansion and suppressor functions (By similarity). As P-selectin/SELPLG ligand, plays a specialized role in activated but not naive T-cell trafficking during inflammatory responses (PubMed:24703780). Controls thereby T-cell accumulation in the inflamed central nervous system (CNS) and the induction of autoimmune disease (PubMed:24703780). Regulates also expression of various anti-inflammatory cytokines and co-inhibitory ligands including IL10 (By similarity). Acts as regulator of T-cell proliferation (By similarity). May play a role in kidney injury and repair (PubMed:17471468). (Microbial infection) Acts as a receptor for Hepatitis A virus. (Microbial infection) Acts as a receptor for Ebolavirus and Marburg virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:21536871). Serves as a dual receptor for Ebolavirus by also interacting with envelope glycoprotein GP (PubMed:26487564). (Microbial infection) Acts as a receptor for Dengue virus by binding exposed phosphatidyl-serine at the surface of virion membrane (PubMed:23084921). TIM1 and Dengue virus are co-internalized during virus entry (PubMed:29742433). (Microbial infection) Acts as a receptor for Zika virus by binding to envelope protein E. (Microbial infection) Plays a positive role in Chikungunya virus cell entry. Interacts with STAM (PubMed:29742433). Interacts with SELPLG (PubMed:24703780). (Microbial infection) Interacts with hepatitis A virus capsid proteins. (Microbial infection) Interacts with Ebolavirus envelope glycoprotein GP. (Microbial infection) Interacts with Zika virus envelope protein E. Widely expressed, with highest levels in kidney and testis. Expressed by activated CD4+ T-cells during the development of helper T-cells responses. Up-regulated in the kidney in renal diseases (at protein level). Ubiquitinated at two lysine residues Lys-338 and Lys-346 on its cytoplasmic domain. Ubiquitination promotes receptor endocytosis and target receptors for lysosomal degradation and termination of receptor signaling. (Microbial infection) Ubiquitination is required for Dengue virus endocytosis. The region containing tandem repeats is polymorphic and the sequence shown here corresponds to the most common allele (PubMed:14534576). An association between hepatitis A virus (HAV) infection and atopic diseases has been observed in individuals with that allele (PubMed:14534576). Allelic variation does not affect HAV-infection rates in Caucasians, Asians and African Americans (PubMed:14534576). The extracellular part of the protein can be cleaved and detected in urine and is in correlation with the expression in the kidney. Belongs to the immunoglobulin superfamily. TIM family.