NADP(+) + S-(hydroxymethyl)glutathione = H(+) + NADPH + S-formylglutathione NAD(+) + S-(hydroxymethyl)glutathione = H(+) + NADH + S-formylglutathione a primary alcohol + NAD(+) = an aldehyde + H(+) + NADH a secondary alcohol + NAD(+) = a ketone + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily.