Catalyzes the pyridoxal-phosphate-dependent breakdown of 5-phosphohydroxy-L-lysine, converting it to ammonia, inorganic phosphate and 2-aminoadipate semialdehyde. (5R)-5-phosphooxy-L-lysine + H2O = (S)-2-amino-6-oxohexanoate + NH4(+) + phosphate Homotetramer. The disease is caused by variants affecting the gene represented in this entry. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. Does not seem to possess aminotransferase activity.