TIR-NB-LRR receptor-like protein that may play a role in plant innate immunity. May trigger hypersensitive programmed cell death in response to pathogen attack (PubMed:20949080). Involved in tolerance to tobacco ringspot virus (TRSV) (PubMed:22057987). H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide Up-regulated by ASHH2 via epigenetic chromatin H3K36me3 regulation during the vegetative development. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Plants over-expressing LAZ5 exhibit hypersensitive cell death and do not survive (PubMed:20949080). In the ecotype Estland (Est), which shows a sensitive response upon tobacco ringspot virus (TRSV) inoculation, the TTR1 allele is involved in the development of lethal systemic necrosis in response to TRSV (PubMed:22057987).