Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity). Interacts with COP1 (PubMed:27041596). May associate with the cytoskeleton. Highly expressed in peripheral blood leukocytes. The protein kinase domain is predicted to be catalytically inactive. Antibodies against TRIB2 are present in sera from patients with autoimmune uveitis. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily.