Cleaves REN2 at a dibasic site to yield mature renin. Hydrolyzes mouse Ren2 protein (a species of prorenin present in the submandibular gland) on the carboxy side of the arginine residue at the Lys-Arg-|- pair in the N-terminus, to yield mature renin. Belongs to the peptidase S1 family. Kallikrein subfamily.