PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Inhibited by both FK506 and rapamycin. Interacts with ARFGEF1/BIG1 and the C-terminal of EPB41L2. Belongs to the FKBP-type PPIase family. FKBP2 subfamily.