Involved in the genetic cascade that governs left-right specification. Required for correct asymmetric expression of NODAL, LEFTY and PITX2 (By similarity). Interacts with PPP1R35; this interaction allows the mutual recruitment to the centriole. Colocalizes with the basal bodies at the primary cilium. Expressed at 7.5 dpc. At 8.5 dpc, expressed in telencephalon and somites. At 9.5 dpc, expressed in somites, forelimb bud, basal forebrain and first branchial arch. At 11.5 dpc, expressed in heart primordium and branchial arches. Death at 11.5 dpc due to major developmental defects, including notochord degeneration, imperfect differentiation of somites and neural tube, axial rotation failure and randomized heart looping. Belongs to the rotatin family. Truncated N-terminus.