Outwardly rectifying potassium channel subunit that may coassemble with other Slo-type channel subunits. Activated by high intracellular sodium or chloride levels. Activated upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1. May be regulated by calcium in the absence of sodium ions (in vitro) (By similarity). Interacts (via C-terminus) with FMR1; this interaction alters gating properties of KCNT1 (By similarity). Interacts with CRBN via its cytoplasmic C-terminus (By similarity). Phosphorylated by protein kinase C. Phosphorylation of the C-terminal domain increases channel activity (By similarity). Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa4.1/KCNT1 sub-subfamily.