Negative regulator of the salicylic acid- (SA-) mediated resistance to pathogens, including the biotrophic powdery mildew pathogens Golovinomyces cichoracearum and Blumeria graminis, and the downy mildew pathogen Hyaloperonospora parasitica, probably by limiting the initiation of cell death and the establishment of the hypersensitive response (HR). Prevents ethylene-induced senescence. Binds to phosphatidylinositol-4-phosphate (PtdIns(4)P) in vitro. Expressed ubiquitously in all tissues and organs, including leaves, roots, flowers, stems and siliques. The pleckstrin homology domain (3-110) binds to phosphatidylinositol-4-phosphate (PtdIns(4)P). Enhanced disease resistance salicylic acid-(SA-) dependent to the biotrophic powdery mildew pathogen Erysiphe cichoracearum at a late stage of the infection process and characterized by the formation of necrotic lesions. Enhanced ethylene-induced senescence phenotype. In edr2-6, exaggerated chlorosis and necrosis response to attack by pathogens (e.g. Hyaloperonospora parasitica, Golovinomyces cichoracearum and Blumeria graminis), but not in response to abiotic stresses or attack by the bacterial pathogen Pseudomonas syringae, characterized by initiation of cell death at infection site and hyper sensitive response (HR).