Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Homodimer, and heterodimer with other family members. Expressed in brain, gill, heart, intestine, kidney, liver, ovary, skin, spleen and testis. Expressed throughout development. Expressed in the neural crest, eyes, yolk syncytium, tail bud and caudal somites of somitic embryos. Expressed in the neural crest, gill covers and gill arches, and the pectoral fins of post-somitic embryos. Repressed under stress conditions such as netting. Belongs to the 14-3-3 family.