Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547). Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547). Interacts with DHX33 (PubMed:26100019). Constitutively monomethylated at His-245 by METTL18 (PubMed:23349634, PubMed:33693809). Regulates the function of RPL3 in the dynamics of pre-rRNA processing, ribosome biogenesis, and translation (PubMed:33693809). It is not required for incorporation of RPL3 into ribosomes (PubMed:33693809). Belongs to the universal ribosomal protein uL3 family.