Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (By similarity). Heterodimer with MEIS1 and MEIS2. Exhibits both spatial and temporal colinearity within the main body axis. At 12.5 dpc, is detected in hindgut, urogenital tract, spinal cord and tailbud. Not detected in secondary axes such as the limb and the genital tubercule. Belongs to the Abd-B homeobox family.