Involved in the transport of four structurally unrelated drugs, including doxorubicin and mitoxantrone. Transmembrane domains (TMD) form a pore in the membrane and the ATP-binding domain (NBD) is responsible for energy generation. Inhibited by ortho-vanadate. Heterodimer composed of YheH and YheI. Induced by several classes of structurally unrelated antibiotics, such as erythromycin, fusidic acid or linezolid. Overexpression reduces the sporulation efficiency possibly by modulating the function of KinA. Belongs to the ABC transporter superfamily.