The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FruAB PTS system is involved in fructose transport. D-fructose(out) + N(pros)-phospho-L-histidyl-[protein] = D-fructose 1-phosphate(in) + L-histidyl-[protein] Part of the fruBKA (fru) operon, which is induced in the presence of fructose via the FruR (Cra) regulatory protein (PubMed:33476373). Transcription is repressed by FruR in the absence of fructose (PubMed:33649152). CRP activates expression of the fru operon in the absence of glucose (PubMed:33649152). The two regulators can work independently to control the expression of the operon depending on carbon source availability (PubMed:33649152). The PTS EIIB type-2 domain is phosphorylated by phospho-EIIA on a cysteinyl residue. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the PTS EIIC type-2 domain. The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site. Does not affect growth on fructose or on glucose.