Exhibits arylsulfatase activity towards the artificial substrate 4-methylumbelliferyl sulfate (PubMed:7720070, PubMed:9497243). May be essential for the correct composition of cartilage and bone matrix during development (PubMed:7720070). Has no activity toward steroid sulfates (PubMed:7720070). an aryl sulfate + H2O = a phenol + H(+) + sulfate Binds 1 Ca(2+) ion per subunit. Inhibited by millimolar concentrations of warfarin. Optimum pH is 7. Almost completely inactivated after 10 minutes at 50 degrees Celsius. Expressed in the pancreas, liver and kidney. N-glycosylated. The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The disease is caused by variants affecting the gene represented in this entry. Belongs to the sulfatase family.