Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis (By similarity). Binds 3 Zn(2+) ions. Binds through its N-terminal region to the C-terminus of CD27 and to PXMP2/PMP22. Binds to the C-terminus of TNFRSF18/GITR. Binds to BCL2L1/BCLX isoform Bcl-x(L) but not to BAX (By similarity). In the nucleus, accumulates in dot-like structures. In post-ischemic kidney, found in cells lining the S3 segment of proximal tubules at 12 hours and 1 day post-ischemia. At five and seven days post-ischemia, found in epithelial cells of papillary proliferations in regenerating tubules. By ischemia.