Coenzyme A diphosphatase which mediates the cleavage of CoA into 3',5'-ADP and 4'-phosphopantetheine. Has a strong preference for oxidized CoA disulfide (CoASSCoA) as substrate. May be required to remove potentially toxic oxidized CoA disulfide to maintain the capacity for beta-oxidation of fatty acids. Can degrade 8-oxo-dGTP in vitro; however, such activity may not be relevant in vivo. 8-oxo-dGTP + H2O = 8-oxo-dGMP + diphosphate + H(+) Optimum pH is 7.0. The size of the cleaved transit peptide can be of 7 or 8 residues. Present with 238 molecules/cell in log phase SD medium. Belongs to the Nudix hydrolase family. PCD1 subfamily.