F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Homodimer; antiparallel. Also forms heterodimers with ACTN3. Interacts with ADAM12, MYOZ1, MYOZ2 and MYOZ3. Interacts via its C-terminal region with the LDB3 PDZ domain. Interacts with XIRP2. Interacts with DST isoform 1 (via N-terminus). Interacts with PARVB. Interacts with SYNPO2. Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle. Expressed in both skeletal and cardiac muscle. Ubiquitinated by FBXL22, leading to proteasomal degradation. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the alpha-actinin family.