Cation-chloride cotransporter which mediates the electroneutral transport of chloride, potassium and/or sodium ions across the membrane (PubMed:32658972). Plays a vital role in the regulation of ionic balance and cell volume. Homodimer. Widely expressed. High expression found in the cochlea, cochlear lateral wall, and the choroid plexus (PubMed:32294086). Lower expression found in the cerebellum and the cortex (PubMed:32294086). Belongs to the SLC12A transporter family.