Part of a bi-component leucotoxin that acts by forming pores in the membrane of the target cells. The activity of LukEv-LukDv to rabbit leukocytes is similar to that of the Panton-Valentine leucocidin (PVL). LukEv-LukDv is hemolytic to rabbit red blood cells although the activity is only 8% of gamma-hemolysin (By similarity). Toxicity requires sequential binding and synergistic association of a class S and a class F component which form heterooligomeric complexes. LukEv (class S) associates with LukDv (class F) (By similarity). Belongs to the aerolysin family.