Blocks the binding of HNRNPA1 to the intronic sequences flanking exon 9 of the PKM gene by competitively binding to the HNRNPA1 RGG-box motif (PubMed:28985503). This inhibits inclusion of exon 9 and promotes inclusion of exon 10, suppressing formation of the PKM M2 isoform and promoting production of the M1 isoform (PubMed:28985503). Also suppresses HNRNPA1-mediated processing of microRNA 18a (miR-18a) (PubMed:28985503). Promotes MYC stability through interaction with IGF2BP2 (PubMed:34457052). Interacts with HNRNPA1 (via the RGG-box) (PubMed:28985503). Interacts with IGF2BP2 (PubMed:34457052). By blocking HNRNPA1-dependent PKM splicing, inhibits colon cancer cell aerobic glycolysis and suppresses colon cancer cell growth, colony formation, migration and invasion (PubMed:28985503). Promotes the proliferation and viability of oral squamous cell carcinoma cells (PubMed:34457052).