Plays a central role in cell adhesion in hematopoietic cells (PubMed:19234463, PubMed:26359933). Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3) (By similarity). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells (PubMed:19234460). Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs) (By similarity). Isoform 2 may act as a repressor of NF-kappa-B and apoptosis. Interacts with ITGB1, ITGB2 and ITGB3 (via cytoplasmic tails). Present in the F-actin surrounding ring structure of podosomes, which are specialized adhesion structures of hematopoietic cells. Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies. The FERM domain is not correctly detected by PROSITE or Pfam techniques because it contains the insertion of a PH domain. The disease is caused by variants affecting the gene represented in this entry. Belongs to the kindlin family.