Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Tetramer of 2 light chains (p10 proteins) and 2 heavy chains (p36 proteins). In the lamina beneath the plasma membrane. Adult brain, heart, striated muscle, liver, kidney, and very high levels in skin. Throughout oogenesis and in mature eggs. Constant levels during early embryogenesis, but decrease at 8h. After midblastula transition, the steady state level increases substantially. A pair of annexin repeats may form one binding site for calcium and phospholipid. It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Belongs to the annexin family.