The complex LTO1:YAE1 functions as a target specific adapter that probably recruits apo-ABCE1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery (PubMed:26182403). May be required for biogenesis of the large ribosomal subunit and initiation of translation (PubMed:23318452). May play a role in the regulation of proline metabolism and ROS production (PubMed:24930674). Forms a complex with YAE1 (PubMed:23318452). Interacts with PYCR1 and PYCR2 (PubMed:24930674). Widely expressed. Highly expressed in placenta, kidney and skeletal muscle. Amplified and overexpressed in oral cancer cells. Belongs to the LTO1 family.