Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. G proteins are composed of 3 units, alpha, beta and gamma. In this context, interacts with GNAI2 and GNG2 (By similarity). Interacts with ARHGEF18 and RASD2. Interacts with ATXN10. Interacts with SCN8A. Belongs to the WD repeat G protein beta family.