Predominantly expressed in thymus, spleen, and testis. Expressed at lower levels in brain, lung, kidney, and ovary. Up-regulated by IFNG/IFN-gamma in human monocytic cell line THP-1. The disease may be caused by variants affecting the gene represented in this entry. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. GTPBP1 subfamily.