Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(pop1-pop2) is required for the maintenance of ploidy and directs ubiquitination of cig2. Protein modification; protein ubiquitination. Component of multiple SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes formed of cul1, skp1, pip1 and a variable F-box domain-containing protein as substrate-specific subunit (By similarity). Binds to the pop1 homodimer, the pop2 homodimer and the pop1/pop2 heterodimer forming the SCF(pop1-pop2) complex. Interacts with pof3, pof14 and skp1. Neddylated; enhancing the ubiquitin-ligase activity. Belongs to the cullin family.