Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types. Interacts with F-actin. Interacts with ANKRD54. Interacts with KBTBD10 (By similarity). Associated with the F-actin rich cortical cytoskeleton. Expressed in a wide range of tissues (but not the heart or skeletal muscle), the expression is specific for certain actin-rich cell types within these tissues. Expression is prominent in the cortical regions of ion-transporting duct cells in the pancreas, in the salivary parotid gland and in certain F-actin-rich cells in the distal tubule/collecting duct. In primary cultures of gastric fibroblasts, expression is mainly within the tips of lamellipodia and at the leading edges of membrane ruffles. Phosphorylated.