Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins. Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. ATP + biotin + L-lysyl-[protein] = AMP + diphosphate + H(+) + N(6)-biotinyl-L-lysyl-[protein] (R)-pantothenate + ATP = (R)-4'-phosphopantothenate + ADP + H(+) A monovalent cation. Ammonium or potassium. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. In the N-terminal section; belongs to the biotin--protein ligase family. In the C-terminal section; belongs to the type III pantothenate kinase family.