Involved in the regulation of lipid metabolism in adipose tissue and liver. May interact with ERFE. Knockout mice are born at the expected Mendelian ratio and appear normal with no gross developmental abnormalities. A reduction of body weight is observed in male, but not female, due to increased metabolic rate and energy expenditure. CTRP2 deficiency up-regulates the expression of lipolytic enzymes and protein kinase A signaling, resulting in enhanced adipose tissue lipolysis. Knockout mice also have altered hepatic and plasma lipid profiles. In contrast to lipid metabolism, whole-body glucose metabolism is not affected. It is uncertain whether Met-1 or Met-10 is the initiator.