Member of the two-component regulatory system ResD/ResE involved in the global regulation of aerobic and anaerobic respiration. Probably phosphorylates ResD. ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Oligomerizes, probably forms homodimers. Interacts in vivo with FloT, colocalizes with FloT-only membrane rafts. Oligomerization is assisted by FloT (PubMed:26297017, PubMed:25909364). Another study shows only minor colocalization with FloT membrane assemblies (PubMed:27362352).