Effector that triggers cell death in a variety of plant species (including tobacco, tomato and soybean), regardless of the Rps genes present (PubMed:22816601). Avh241 interacts with the plant immune system via at least two different mechanisms, one recognized by plants dependent on subcellular localization and one promoting infection independent on membrane localization (PubMed:22816601). The cell death triggered by Avh241 in N.benthamiana requires the two host mitogen-activated protein kinases, MEK2 and WIPK (PubMed:22816601). The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate. The GAAKAK motif at position 73-78 is required for host plasma membrane localization. Belongs to the RxLR effector family.