May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. Interacts with WT1. Interacts with DEPDC1A. Colocalizes with DEPDC1A at the nucleus. Ubiquitous. Mainly expressed in fetal tissues. Belongs to the krueppel C2H2-type zinc-finger protein family.