Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Component of the large ribosomal subunit. Interacts with DHX33 (PubMed:26100019). Constitutively monomethylated at His-245 by METTL18. Regulates the function of RPL3 in the dynamics of pre-rRNA processing, ribosome biogenesis, and translation. It is not required for incorporation of RPL3 into ribosomes. Belongs to the universal ribosomal protein uL3 family.