DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA (By similarity). Endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate. In the N-terminal section; belongs to the MGMT family. In the C-terminal section; belongs to the endonuclease V family.