Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Essential for male fertility, sperm head morphogenesis and sperm flagellum formation (PubMed:31961863). Not required for ciliogenesis in the brain and trachea (PubMed:31961863). Component of the nexin-dynein regulatory complex (N-DRC) (By similarity). Interacts with TCTE1/DRC5 (PubMed:28630322, PubMed:31961863). Interacts with DRC3 and GAS8/DRC4 (PubMed:31961863). Associated with the outer doublet microtubules (OD). Expressed in diplotene and pachytene spermytocytes, and in round and elongating spermatids (at protein level). Strongly expressed in spleen and testis, faintly expressed in kidney, ovary and thymus. Abundantly expressed in the testis and is weakly expressed in the brain, thymus, lung and ovary (PubMed:31961863). Expressed in ciliated cells (PubMed:17971504). Male mice were infertile due to their short immotile spermatozoa (PubMed:31961863). Axoneme formation and manchette removal are impaired in spermatids (PubMed:31961863). No morphological abnormalities seen in multicilia of ependymal and tracheal epithelia and cilia motility is not impaired in ependymal cilia (PubMed:31961863). Belongs to the DRC7 family.