CoA + 2 oxidized [2Fe-2S]-[ferredoxin] + pyruvate = acetyl-CoA + CO2 + H(+) + 2 reduced [2Fe-2S]-[ferredoxin] Optimum pH is 10.0. Optimum temperature is 80 degrees Celsius. Heterotetramer of one alpha, one beta, one delta and one gamma chain.