Enzyme which catalyzes the acetylation of polyamines. Displays higher substrate specificity for spermine than for spermidine. May function to acetylate host-derived polyamines, thus alleviating the necessity for de novo synthesis of these molecules. acetyl-CoA + an alkane-alpha,omega-diamine = an N-acetylalkane-alpha,omega-diamine + CoA + H(+) Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1. Homotetramer. Belongs to the acetyltransferase family.