Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them (By similarity). This toxin also inhibits high voltage-activated (HVA) calcium channel currents in rat DRG neurons (8% inhibition at 1 uM toxin) probably by activating GABA(B) receptors (GABBR1 and/or GABBR2) (PubMed:26948522). Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/7 pattern. Belongs to the conotoxin A superfamily. The synthetic peptide described in PubMed:26948522 is one residue shorter than the mature sequence shown in this entry (44-60) (the Arg-43 is removed) and the Cys-60 is amidated.