Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). Interacts with ATG8 family proteins (via AIM motifs), and ubiquitin (via CUE domain). Both ATG8-interaction motifs (AIM1 and AIM2) are required for the association with ATG8 family proteins. Belongs to the tollip family.