Exhibits lipoxin synthase activity as part of a bacterial evasion strategy to suppress the host immune defense (PubMed:31474948). Oxygenates polyenoic fatty acids including eicosatrienoate and docosahexaenoate to the corresponding (n-6)S-hydroperoxy derivatives (PubMed:14766977, PubMed:27500637). In turn, this production of bioactive lipid mediators promotes bacterial persistence in host lung tissues by inhibiting the expression of major chemokines and recruitment of leukocytes (PubMed:31474948). (8Z,11Z,14Z)-eicosatrienoate + O2 = (15S)-hydroperoxy-(8Z,11Z,13E)-eicosatrienoate (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 = (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 = (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (9Z,12Z)-octadecadienoate + O2 = (13S)-hydroperoxy-(9Z,11E)-octadecadienoate (11Z,14Z)-eicosadienoate + O2 = (15S)-hydroperoxy-(11Z,13E)-eicosadienoate Binds 1 Fe cation per subunit. Lipid metabolism; fatty acid metabolism. Periplasmic with some activity further secreted to the extracellular milieu. Belongs to the lipoxygenase family.