Shows strong antibacterial activity against the Gram-positive bacterium M.luteus (PubMed:23802451). Also shows antibacterial activity against the Gram-positive bacteria E.fecalis, S.aureus, S.carnosus, S.pneumoniae and S.pyogenes and against a number of methicillin-resistant S.aureus and glycopeptide-intermediate S.aureus isolates (By similarity). Does not show antibacterial activity against Gram-negative bacteria or antifungal activity against C.utilis (By similarity). Shows slight antifungal activity against C.albicans (By similarity). Larval fat body, hemolymph and salivary glands (at protein level). The disulfide bonds are essential for antimicrobial activity. During maggot debridement therapy which involves the controlled application of cultured sterile larvae to an infected chronic non-healing wound, one of the key factors which protects larvae against the infectious wound environment and contributes to wound healing through its antimicrobial activity. Belongs to the invertebrate defensin family. Type 1 subfamily.