PPIases accelerate the folding of proteins (PubMed:11264535). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:11264535). Involved in promoting the expression of the juvenile phase of vegetative development, and, to a lower extent, in regulating the positioning of floral buds, floral morphogenesis and the expression of HSPs (PubMed:11264535). Collaboratively with RBL and ULT1, influences floral meristem (FM) determinacy in an AGAMOUS and SUPERMAN-dependent manner, thus contributing to the floral developmental homeostasis (PubMed:18441215). [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase (By similarity). Expressed at low levels in seedlings, roots, shoots, leaves, stems, inflorescences, flowers and siliques, with highest levels dividing tissues. Plants lacking both CRC and CYP40/SQN exhibit strong floral meristem (FM) indeterminacy with reiterations of extra floral whorls in the center of the flower associated with reduced AGAMOUS and SUPERMAN levels. Belongs to the cyclophilin-type PPIase family.