Plays an important role in the degradation of dermatan and keratan sulfates. a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate Inhibited by L-aspartic acid. Homotetramer. Defects in GUSB are the cause of mucopolysaccharidosis type VII (MPS VII), an inherited disease reported in humans, mice, cats, and dogs. Belongs to the glycosyl hydrolase 2 family.