G-protein coupled receptor for PEN, a neuropeptide produced from the precursor protein, proSAAS (encoded by PCSK1N). Acts through a G(i)- and G(q)-alpha-alpha-mediated pathway in response to PEN (PubMed:27117253). Plays a role in food intake and body weight regulation (PubMed:23744028). May contribute to the regulation of anxiety-related behaviors (PubMed:34512237). Colocalizes with GPR171 in the paraventricular nucleus (PubMed:27117253). Colocalizes with the ghrelin receptor GHSR1A in the hypothalamus (PubMed:23744028). Experimental confirmation may be lacking for some isoforms. Predominantly expressed in the brain, with moderate expression in the hypothalamus (PubMed:23744028). Expressed in the thymus (PubMed:16141072). By glucocorticoids and cAMP in T-cells. Deficient mice have normal body weight and glucose tolerance when fed a regular chow diet, but are protected from obesity and glucose intolerance when challenged with a high-fat diet (PubMed:23744028). Knockdown of GPR83 has minimal impact on anxiety-like behaviors in female mice and a decrease in anxiety-related behaviors in male mice. In contrast, a local GPR83 knockdown in the basolateral amygdala leads to more anxiety-related behaviors in female mice (PubMed:34512237). Belongs to the G-protein coupled receptor 1 family. NPY has been reported to be a ligand for GPR83 (By similarity). However, a more recent study found that radiolabeled PEN binding to GPR83 is not affected by NPY concentrations below 1 mM, only very high, non-physiological concentrations causes a partial, displacement of PEN binding (PubMed:27117253).