Aldo-keto reductase; part of the gene cluster that mediates the biosynthesis of sansalvamide, a cyclic pentadepsipeptide that shows promising results as potential anti-cancer drug (PubMed:26936154). The nonribosmal peptide synthetase NRPS30 produces sansalvamide by incorporating successively one phenylalanine, one leucine, one alpha-hydroxyisocaproic acid (HICA), one valine and one leucine before sansalvamide is released from by cyclization by the terminal C domain of NRPS30 (PubMed:26936154). The HICA residue is probably provided by reduction of alpha-ketoisocaproate by the cluster-specific aldo-keto reductase (NECHADRAFT_45914) (Probable). Secondary metabolite biosynthesis. Belongs to the aldo/keto reductase family.