TIR-NB-LRR receptor-like protein that confers broad-spectrum resistance and full immunity to several races of the pathogen Albugo candida (white rust disease) (PubMed:18624640). Confers resistance to the biotrophic pathogens Pseudomonas syringae pv. tomato DC3000 and Hyaloperonospora arabidopsis isolate Noco2 (PubMed:19549129). May play a role in the response to UV stress (PubMed:25656510). H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide By UV treatment. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. No visible phenotype under normal growth conditions, but mutant plants are susceptible to white rust fungal pathogen Albugo candida subsp. B (PubMed:18624640). Increased resistance on UV-induced growth inhibition (PubMed:25656510). The gain-of-function mutants adr2 (T-DNA tagging) are dwarf, develop HR-like lesions on leaves, express constitutively defense and antioxidant-related genes, and have increased resistance to biotrophic pathogens.