E3 ubiquitin-protein ligase (By similarity). Functions in the OLL neurons in the anterior ganglion to inhibit avoidance to microbial pathogens such as P.aeruginosa although worms do display avoidance behavior, vacating a P.aeruginosa lawn within 24 hours (PubMed:22089131). Likely to act by inhibiting the neuropeptide receptor npr-1 (PubMed:22089131). S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Expressed in the nervous system throughout the body. In the anterior ganglion, expression is limited to the two lateral outer labial neurons OLLL and OLLR.