Functions as a pleiotropic drug pump at the plasma membrane to clear toxic substances from the cytosol. Organic anion transporter involved in the detoxification of a wide range of toxic environmental organic anions that contain carboxyl groups (PubMed:8663018). Required for tolerance to reveromycin A, tautomycin and leptomycin B (PubMed:8663018). Required for oligomycin resistance (PubMed:8524254, PubMed:10082567). Required for rhodamine B resistance. Mediates the ATP-dependent efflux of rhodamine B (PubMed:9575223). Involved in cadmium detoxification. Displays an energy-dependent efflux of cadmium and glutathione, suggesting that YOR1 transports both compounds as a bis-glutathionato-cadmium Cd-(GS)(2) complex (PubMed:16814918). Confers resistance to rhodamine 6G and to doxorubicin (PubMed:17950691). a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ADP + H(+) + phosphate ATP + Cd(2+)(in) + H2O = ADP + Cd(2+)(out) + H(+) + phosphate an S-substituted glutathione(in) + ATP + H2O = ADP + an S-substituted glutathione(out) + H(+) + phosphate Transcriptionally regulated by PDR8. Present with 3610 molecules/cell in log phase SD medium. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.