Regulator of adipocytes that acts by repressing FOXO1 transcriptional activity. Acts by promoting acetylation of FOXO1, both by preventing the interaction between FOXO1 and SIRT1 deacetylase, and by mediating acetyltransferase activity in vitro. Regulates insulin sensitivity and energy metabolism. Interacts with FOXO1 (via N-terminal domain); the interaction is direct, occurs in a forskolin-independent manner that prevents SIRT1 binding to FOXO1. Interacts with FOXO3. Does not interact with FOXO4. Imported into the nucleus following phosphorylation at Thr-93 upon treatment of cells with forskolin. Probably shuttles between the nucleus and the cytoplasm. Expressed in adipocytes. Expressed in brown and white adipose tissue but not in liver. Protein levels in brown and white adipose tissues decrease following fasting (at protein level). Expressed in white and brown adipose tissues. Expressed in adipocytes. Not expressed in liver, skeletal muscle and brain. Up-regulated during adipocyte differentiation. Up-regulated by starved state in white (WAT) and brown (BAT) adipose tissues. Down-regulated during fasting in WAT and BAT. Up-regulated during cold exposure in BAT. Phosphorylated at Thr-93 by PKA, leading to import into the nucleus. Mice are glucose intolerant and insulin resistant, despite being leaner than wild-type mice. It is unclear whether the protein is conserved in human: no ortholog has been identified yet although antibodies against Fcor stain human tissues.