Catabolizes phenol, and some of its methylated derivatives. P5 is required for growth on phenol, and for in vitro phenol hydroxylase activity (By similarity). Probable electron transfer from NADPH, via FAD and the 2Fe-2S center, to the oxygenase activity site of the enzyme. H(+) + NADPH + O2 + phenol = catechol + H2O + NADP(+) Binds 1 FAD. Binds 1 [2Fe-2S] cluster. Aromatic compound metabolism; phenol degradation. The multicomponent enzyme phenol hydroxylase is formed by P0, P1, P2, P3, P4 and P5 polypeptides. By phenol.