May play an important role in inflammation and regeneration of skeletal muscle (By similarity). Essential for embryonic development (By similarity). Has chemotactic response in monocytes, neutrophils and lymphocytes (PubMed:12706894). Binds CCR4 (By similarity). Both isoforms have highest expression levels in testis with relatively lower expression level in liver, spleen, lung, brain and heart and barely detectable levels in skeletal muscle and kidney were barely detected. In most tissues, isoform CKLF2 has higher expression levels than isoform CKLF1. Belongs to the chemokine-like factor family.