DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. ATP + H2O = ADP + H(+) + phosphate Interacts with NFE2L2; involved in activation of the transcription. Enriched at sites of mRNA synthesis. Widely expressed. Mice with targeted deletion of exon 12 lacking part of the Helicase ATP-binding domain are born in normal Mendelian ratios and are viable. They are fertile and exhibit no obvious morphological or histological difference. However, they display a coordination deficiency which is not due to muscle weakness or bradykinesia. Belongs to the SNF2/RAD54 helicase family. Extended N-terminus. Probable cloning artifact. Spurious priming from an intronic poly-A tract.