Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required for normal embryogenesis (By similarity). Plays a role in regulating Notch activity. Associates with the pre-60S ribosomal particle. Interacts (via WD repeats) with uL18 (By similarity). Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain) (By similarity). Maternally transcribed, with constant expression during early stages of embryogenesis. Levels increase at the end of gastrulation and are maintained during neurulation and organogenesis. During later stages expressed in somites, segmental plate, brain, branchial arches, eyes and ventral bood islands. Belongs to the NLE1/RSA4 family.