Isocyanide synthase-NRPS hybrid; part of the crm gene cluster that mediates the biosynthesis of a yet unidentified copper-responsive metabolite. Secondary metabolite biosynthesis. Expressed in copper depleted conditions via the regulation of the macA transcription factor. Does not affect the xanthocillin production. In the N-terminal section; belongs to the isocyanide synthase family. In the C-terminal section; belongs to the NRP synthetase family. The predicted genes AFUA_3G13690 and AFUA_3G13700 have been merged into 1 gene: crmA. The predicted genes AFUA_3G13690 and AFUA_3G13700 have been merged into 1 gene: crmA.