Part of a complex with lis-1, which is recruited to the nuclear envelope by unc-83, where, in turn, it recruits dynein to the nuclear surface and regulates nuclear migration in hypodermal precursor cells (PubMed:20005871, PubMed:27697906). Plays a role in GABAergic synaptic vesicle localization in the ventral nerve cord (PubMed:16996038). Component of a dynein-regulating complex composed of at least lis-1 and nud-2 (PubMed:20005871). Interacts with lis-1; the interaction is direct (PubMed:16996038). Interacts (via C-terminus) with unc-83; the interaction is direct, and is required for recruitment of nud-2 to the nuclear envelope (PubMed:20005871). Recruited to the nuclear envelope by unc-83. Expressed in ventral cord neurons, the pharynx, seam cells of the hypodermis and in vulval muscle cells. RNAi-mediated knockdown results in viable animals, but a small, but significant number of animals have nuclear migration defects in hyp7 hypodermal precursor cells (PubMed:20005871). RNAi-mediated knockdown results in an abnormal distribution of GABAergic synaptic vesicles at synaptic termini of the ventral nerve cord (PubMed:16996038). RNAi-mediated knockdown in combination with exposure to pentylenetetrazole, a GABA antagonist that induces seizures, results in impaired locomotion, stiffened appearance and an increased convulsion incidence as compared to wild-type animals (PubMed:16996038). Belongs to the nudE family.