Catalyzes the oxidation of medium and long chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length (PubMed:9133646, PubMed:22633490, PubMed:25047030, PubMed:18035827, PubMed:9662422, PubMed:18182499). Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH a fatty aldehyde + H2O + NAD(+) = a fatty acid + 2 H(+) + NADH (2E)-hexadecenal + H2O + NAD(+) = (E)-hexadec-2-enoate + 2 H(+) + NADH 2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+) 22-oxodocosanoate + H2O + NAD(+) = docosanedioate + 2 H(+) + NADH 2,6,10,14-tetramethylpentadecanal + H2O + NAD(+) = 2,6,10,14-tetramethylpentadecanoate + 2 H(+) + NADH H2O + NAD(+) + octadecanal = 2 H(+) + NADH + octadecanoate dodecanoate + 2 H(+) + NADH = dodecanal + H2O + NAD(+) decanal + H2O + NAD(+) = decanoate + 2 H(+) + NADH H2O + NAD(+) + tetradecanal = 2 H(+) + NADH + tetradecanoate H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate H2O + heptanal + NAD(+) = 2 H(+) + heptanoate + NADH (2E,6E)-farnesal + H2O + NAD(+) = (2E,6E)-farnesoate + 2 H(+) + NADH kcat is 2.18 sec(-1) for decanal as substrate. kcat is 2.23 sec(-1) for dodecanal as substrate. kcat is 0.86 sec(-1) for tetradecanal as substrate. kcat is 0.95 sec(-1) for hexadecanal as substrate. kcat is 1.52 sec(-1) for octadecanal as substrate. kcat is 0.93 sec(-1) for farnesal as substrate. kcat is 1.28 sec(-1) for NAD as substrate. Optimum pH is 9.8. Homodimer. Detected in liver (at protein level). The disease is caused by variants affecting the gene represented in this entry. Belongs to the aldehyde dehydrogenase family.