Superoxide dismutases serve to convert damaging superoxide radicals, a key form of ROS, to less damaging hydrogen peroxide that can be converted into water by catalase action. Degrades host-derived reactive oxygen species to escape innate immune surveillance. Involved in the occurrence of miconazole-tolerant persisters in biofilms. Persisters are cells that survive high doses of an antimicrobial agent. The unusual attributes of SOD5-like fungal proteins, including the absence of zinc and an open active site that readily captures extracellular copper, make these SODs well suited to meet challenges in zinc and copper availability at the host-pathogen interface. 2 H(+) + 2 superoxide = H2O2 + O2 Binds 1 copper ion per subunit. Secreted in a disulfide-oxidized form and apo-pools of secreted SOD5 can readily capture extracellular copper for rapid induction of enzyme activity. Monomer. Covalently-linked GPI-modified cell wall protein (GPI-CWP). Induced during yeast-to-hyphal transition and by osmotic and oxidative stresses. Expression is also increased when cells were grown on nonfermentable substrates as the only carbon source, in serum, and in the presence of neutrophils. Down-regulated by shikonin. Expression is controlled by EFG1, NRG1 and RIM101. The GPI-anchor is attached to the protein in the endoplasmic reticulum and serves to target the protein to the cell surface. There, the glucosamine-inositol phospholipid moiety is cleaved off and the GPI-modified mannoprotein is covalently attached via its lipidless GPI glycan remnant to the 1,6-beta-glucan of the outer cell wall layer (By similarity). Leads to sensitivity to hydrogen peroxide when cells were grown in nutrient-limited conditions. Belongs to the Cu-Zn superoxide dismutase family. Although the beta-barrel of Cu/Zn SODs is largely preserved, SOD5 is a monomeric copper protein that lacks a zinc-binding site and is missing the electrostatic loop element proposed to promote catalysis through superoxide guidance. Without an electrostatic loop, the copper site of SOD5 is not recessed and is readily accessible to bulk solvent (PubMed:24711423).