Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand. GTP = 3',5'-cyclic GMP + diphosphate Homodimer. Phosphorylation of the protein kinase-like domain is required for full activation by ANP. Mice display systemic hypertension associated with cardiac hypertrophy and ventricular enlargement. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.