E3 ubiquitin ligase acting as a negative regulator of oxidative stress tolerance, probably by mediating 26S proteasome-mediated degradation of PRMT13/PRMT4B, thus preventing APX1 and GPX1 accumulation via the reduction of histone H3 methylation (H3R17me2a). Confers sensitivity to cadmium CdCl(2) and salt NaCl stresses. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Interacts with PRMT13/PRMT4B in the nucleus. Expressed constitutively in both shoot and root tissues. Repressed rapidly by oxidative stress such as paraquat, hydrogen peroxide H(2)O(2), mannitol, drought and cadmium ion CdCl(2). Increased tolerance to paraquat-triggered oxidative stress associated with PRMT13/PRMT4B, APX1 and GPX1 accumulation due to increased histone H3 methylation (H3R17me2a).