Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:3285469, PubMed:2204832). Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (By similarity). Stimulates actin polymerisation (By similarity). beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate The cytoplasmic tail of TRAP and probably other adhesins acts as a competitive inhibitor as the binding sites of the glycolytic substrate fructose 1,6-bisphosphate and TRAP partially overlap (By similarity). Inhibited by suramin, an antiparasitic drug used to treat Trypanosome-mediated infection (PubMed:2204832). Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Homotetramer (PubMed:3285469, PubMed:2204832). Interacts with TRAP (via cytoplasmic domain); the interaction prevents substrate binding and thereby inhibits aldolase activity (By similarity). Interacts with MTRAP (via cytoplasmic domain); MTRAP phosphorylation may increase the binding to FBPA (By similarity). Interact with RH1 (via cytoplasmic domain) (By similarity). Interacts with RH2b (via cytoplasmic domain) (By similarity). Interacts with RH4 (via cytoplasmic domain) (By similarity). Interacts with AMA1 (via cytoplasmic domain); the interaction is weak, however it may be increased upon AMA1 phosphorylation (By similarity). Interacts with EBA140 (via cytoplasmic domain); the interaction is weak (By similarity). Interacts with EBA175 (via cytoplasmic domain); the interaction is weak (By similarity). Interacts with EBA181 (via cytoplasmic domain); the interaction is weak (By similarity). Interacts with G-actin and F-actin (By similarity). May interact with ACT2/actin II; the interaction inhibits FBPA catalytic activity (PubMed:2204832). Interacts with human SLC4A1/band 3 (via N-terminus); the interaction inhibits FBPA catalytic activity (PubMed:2204832). Expressed during parasite asexual blood stages (at protein level). May be an effective malaria vaccine as determined by epitope response in sera (PubMed:3285469). Antibodies against FBPA inhibit its catalytic activity (PubMed:3285469, PubMed:2204832). Belongs to the class I fructose-bisphosphate aldolase family.