Involved in segment polarity. In complex with gft/CUL3, promotes ubiquitination of ci and its subsequent degradation by the proteasome, which results in hh signaling attenuation. This regulation may be important during eye formation for proper packing of ommatidia into a hexagonal array. Protein modification; protein ubiquitination. Interacts with ci and gft/CUL3. Expressed near the anterio-posterior compartment boundary of antenna, leg and wing disks. Expressed maternally in stage 1 embryos. Isoform 1 and isoform 4 are expressed zygotically in stage 4 in pole cells. By stage 8, expressed in 14 segmentally repeating stripes. During stage 9 and 10, expression appears in neuroblasts. After stage 14, expression is restricted to clypeolabrum, anal plate and salivary glands. By hh during segmentation. The MATH domain interacts with ci. The BTB (POZ) domain interacts with gft/CUL3. Belongs to the Tdpoz family.