May regulate cell migration and differentiation through interaction with and inhibition of SRGAP2 (PubMed:31822692, PubMed:31822692). In contrast to SRGAP2C, it is not able to induce long-lasting changes in synaptic density throughout adulthood (PubMed:31822692). May interact with SRGAP2; formation of the heterodimer alters SRGAP2 function. This is one of the 3 duplications of the ancestral gene SRGAP2/SRGAP2A which has undergone human-specific segmental gene duplications (PubMed:22559944). The appearance of SRGAP2B in the human genome is estimated to 3,4 million years. Two larger duplications later copied SRGAP2B to chromosome 1p12 (SRGAP2C) and to proximal 1q21.1 (SRGAP2D) (PubMed:22559944). SRGAP2B was identified in some individuals but it is not clear if it produces a functional protein (PubMed:22559944).