Specific transcriptional regulator for the azasperpyranone A biosynthesis cluster A. Expression is induced by the azasperpyranone transcriptional regulator ATEG_07667. Results in the significant down-regulation of cluster A, whereas it exerts no influence on cluster B. Azasperpyranones display potential anti-cancer activities (PubMed:31908094). Azasperpyranones A, C, D, and F exhibit potent growth-inhibitory activity against the A549, HepG2, HCT-116, and HL-60 cell lines, with IC(50) values of 2.39-14.42 mm, respectively (PubMed:31908094). Moreover, azasperpyranone D significantly inhibits HCT-116 xenograft tumor growth in BALB/c-nu mice (PubMed:31908094). In addition, azasperpyranones A and C can bind with four kinds of therapeutic targets for cancer, eEF2K, FGFR, survivin, and TNF-a (PubMed:31908094).