Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles (PubMed:20855508). Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively (PubMed:20855508). Hormone secreted by trophoblasts that promotes trophoblast invasiveness (By similarity). Has glucogenic activity: is able to increase plasma glucose levels (PubMed:32329225). Interacts with BMP2, BMP4, BMP7, BMP10 and GDF5. Interacts with MFAP2 and MFAP5. Interacts with ADAMTSL5. Interacts with MFAP4. Fibrillin-2 and Placensin chains are still linked together during the secretion from cells, but are subsequently separated by furin. Secreted by placental cells. Widely expressed. Strongly expressed during the first week of osteoblast differentiation. N-glycosylated. O-glycosylated on serine residues by POGLUT2 and POGLUT3. Limb-patterning defects characterized by bilateral syndactyly due to disorganized matrix (PubMed:11470817). Digit fusion involves both soft and hard tissues and is associated with reduced apoptosis at affected sites (PubMed:11470817). Mice show a well developed and morphologically normal aortic wall (PubMed:16407178). Mice display a low bone mass phenotype that is associated with reduced bone formation (PubMed:20855508). Belongs to the fibrillin family.