Amine transporter (PubMed:1948035, PubMed:1948034, PubMed:1765147, PubMed:1502198). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (Probable) (PubMed:1765147). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1 (By similarity). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with SEPTIN4 (By similarity). Localizes to neurite tips in neuronal cells (PubMed:32963038). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). This protein is the target of psychomotor stimulants such as amphetamines or cocaine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.