Hydrolyzes ADP-ribose (ADPR) to AMP and ribose 5'-phosphate. ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) Monomer. Interacts with GLOD4. Ubiquitously expressed but isoform 1 is the most predominant isoform. Inhibited by fluoride and N-acetyl-p-benzoquinoneimine. Belongs to the Nudix hydrolase family. NudF subfamily.