Cytochrome P450 enzyme (CYP) which catalyzes a unique two-electron oxidation cascade on abieta-8,11,13-triene to produce ferruginol, an intermediate in tanshinone biosynthesis. abieta-8,11,13-triene + O2 + reduced [NADPH--hemoprotein reductase] = ferruginol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Secondary metabolite biosynthesis; terpenoid biosynthesis. Ferruginol is a widespread diterpenoid metabolite that serves as a bioactive natural product in its own right, and has been shown to exhibit a range of activities similar to that of the tanshinones such as anti-tumor and antibacterial properties. It therefore contributes to the medicinal effect of Isodon rubescens. Abietane diterpenoids (e.g. miltiradiene, abietatriene and ferruginol) accumulate specifically in the periderm of roots (PubMed:28381502). The ent-kaurene diterpenoid oridonin, main constituent of Isodon rubescens, accumulates in leaves (PubMed:28381502). Belongs to the cytochrome P450 family.