Multidrug resistance transporter involved in resistance to azole antifungal drugs such as the imidazoles miconazole, ketoconazole, and tioconazole; as well as the triazoles itraconazole and fluconazole (PubMed:26512119). Also plays a role in the resistance to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases the intracellular accumulation of clotrimazole by mediating its extrusion from cells (PubMed:26512119). Plays a role in biofilm formation (PubMed:27780306). Expression is up-regulated by clotrimazole (PubMed:26512119). Expression is also up-regulated during biofilm formation (PubMed:27780306). Leads to intracellular accumulation of clotrimazole and increases the susceptibility to clotrimazole but also to other imidazoles such as miconazole, ketoconazole, and tioconazole; as well as triazoles such as itraconazole and fluconazole (PubMed:26512119). Increases also susceptibility to other antifungal drug families such as the polyene amphotericin B, the pyrimide analog flucytosine, the fungicide mancozeb, and the polyamine spermine (PubMed:26512119). Decreases virulence in a Galleria mellonella model of infection, limits the survival when exposed to phagocytosis and impairs biofilm formation by decreasing the expression ofthe adhesin encoding genes ALS1, EAP1, and EPA1 (PubMed:27780306). Belongs to the major facilitator superfamily. DHA1 family. Polyamines/proton antiporter (TC 2.A.1.2.16) subfamily.