Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation through regulation of histone acetylation (PubMed:30228260). Negatively regulates brown adipocyte thermogenesis by interacting with and stabilizing HDAC1 at the UCP1 gene promoter, thereby promoting histone deacetylation at the promoter leading to the repression of UCP1 expression (PubMed:34180153). Component of a MTA1-specific subcomplex of the NuRD complex composed of PWWP2B, MTA1 and HDAC1 but does not contain CHD4 and MBD3 (By similarity). Interacts with MTA1, MTA2, MTA3, HDAC1, HDAC2, RBBP4, RBBP7, BRCC3 and ZNF516 (PubMed:34180153). Does not interact with CHD4 and MBD3 (By similarity). Expressed in the brown adipose tissue. Induced in response to cold. Deubiquitinated by BRCC3; leading to its stabilization.