May play a role in cortex development as part of the Notch signaling pathway. Downstream of Notch may repress the expression of proneural genes and inhibit neuronal differentiation thereby maintaining neural progenitors (PubMed:19906856). May also play a role in preimplentation embryo development (PubMed:26178919). Expressed in all blastomeres at the 8-cell stage (PubMed:26178919). Detected in the ventricular zone (VZ) of the forebrain at 9.5 dpc. Clearly detected until 12.5 dpc, the expression decreases and disappears by 15.5 dpc (PubMed:19906856). Knockout embryos die before preimplantation. Belongs to the nepro family.