Component of intercellular desmosome junctions. Plays a role in stratified epithelial integrity and cell-cell adhesion by promoting desmosome assembly. Plays a role as an effector in the TP53-dependent apoptotic pathway. Associated with desmosomes (By similarity). Colocalizes with KRT14 in the cell membrane (PubMed:31898316). Expressed in skin, heart, placental, liver, pancreas, keratinocytes and dermal fibroblasts. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the TMEM47 family.