Transcription factor that plays a critical role in response to various stresses and reduces the stress through transcriptional activation of its target genes including multidrug transporter FLR1 (PubMed:17046176). Contains two cysteine rich domains (CRD), referred to as the N- and C-terminal CRD's, n-CRD and c-CRD, respectively (By similarity). A nuclear export signal is embedded in the c-CRD, with which the nuclear export protein CRM1/exportin 1 interacts only in the absence of disulfide bonds (or otherwise oxidized cysteines) within the c-CRD or between the c-CRD and the n-CRD (By similarity). Leads to decreased resistance to hydrogen peroxide, 4-nitroquinoline-N-oxide (4-NQO), benomyl, and cadmium chloride (PubMed:17046176).