The MdtABC tripartite complex confers resistance against novobiocin and deoxycholate. MdtABC requires TolC for its function. Part of a tripartite efflux system composed of MdtA, MdtB and MdtC. MdtC forms a heteromultimer with MdtB. The mdtABC operon is transcriptionally activated by BaeR. Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtC subfamily.