Inhibits fibrinogen interaction with platelets by binding to alpha-IIb/beta-3 (ITGA2B/ITGB3). Also inhibits ADP-induced platelet aggregation. Inhibits basic fibroblast growth factor (bFGF)-induced proliferation of human vascular endothelial cell (HUVEC), and vitronectin-induced migration of smooth muscle cells (SMC). It also regulates platelet activation associated with HUVEC migration and invasion, suppresses TNF-alpha-induced ovarian cancer cell proliferation and invasion, and inhibits angiogenesis and tumor progression. Monomer. Expressed by the venom gland. LD(50) is 400 mg/kg body weight in male mice and 600 mg/kg in female mice (intravenous). From the autopsies of test mice, hepatic congestion is found in dead mice, but the organs of surviving mice lacked any other abnormal indications. The disintegrin belongs to the medium disintegrin subfamily. Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily.