Inhibitor of viral mouvements which confers resistance to some tobamoviruses including tomato mosaic virus (ToMV) (e.g. strains L, B7 and ToMV1-2) and tobacco mosaic virus (TMV), but not to resistance-breaking isolates (e.g. LIIA and ToMV2(2)) ToMV and tomato brown rugose fruit virus (ToBRFV) (PubMed:17238011, PubMed:14558663, PubMed:1730937, PubMed:8411345, PubMed:9612948, PubMed:15290376, PubMed:16172136, PubMed:21310506, PubMed:29582165, PubMed:28107419). Elicits a hypersensitive reaction in response to avirulent (Avr) movement proteins from resistance inducing tobamoviruses (e.g. ToMV and TMV) strains, thus leading to programmed cell death; this local extreme resistance requires rbcS (PubMed:15290376, PubMed:21310506, PubMed:28258211, PubMed:23148080). (Microbial infection) Interacts with tobamoviruses mouvement protein (e.g. tobacco mosaic virus (TMV) MP, AC P03583) at the plasma membrane; this interaction triggers defense responses leading to programmed cell death. Binds to HSP90 proteins (e.g. HSP90-1 and Nicotiana benthamiana HSP90-1); this interaction seems required for defense responses toward tobamoviruses. The Tm-2, Tm-2(2) and Tm-2nv alleles present in the tomato mosaic virus (ToMV/TMV)-resistant tomato cv. Craigella isolates GCR236 (AC Q71BH0), cv. Craigella GCR267 (AC Q71BG9) and cv. Yukang 2 (AC Q5MLE9), respectively confers resistance to ToMV but not the tm-2 allele present in the ToMV-susceptible tomato cv. Craigella isolate GCR26 (AC Q71BH1). Belongs to the disease resistance NB-LRR family.