Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). Expressed in subsets of taste receptor cells of the tongue and palate epithelium and exclusively in gustducin-positive cells. Expressed in the duodenum, antrum and fundus (part of the stomach). Several bitter taste receptors are expressed in a single taste receptor cell. Belongs to the G-protein coupled receptor T2R family. This protein was previously referred to as T2R2 but is now considered to be an ortholog of rat TAS2R23.