On insects, this depressant beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against insects and mammals. It is capable of binding to not only cockroach neuronal membranes, but also rat cerebrocortical and hippocampal synaptosomes. This toxin also has potent peripheral and central suppressive effects on rat nociceptive spontaneous responses, thermal hyperalgesia and spinal c-Fos expression induced by formalin and carrageenan, which may be derived from its modulation on the activity of sodium channels of the neurons. Administration of BmKIT2 into rat brain can also suppress the epileptic seizures significantly. Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.