Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. Homodimer. Interacts with PIEZO1 and PIEZO2. Detected in lipid rafts, in apical dendrites and in olfactory cilia. Expressed by all dorsal root ganglion neurons and is selectively expressed in neuronal tissues. Detected in olfactory epithelium. In deficient mice 35% of skin mechanoreceptors do not respond to mechanical stimuli. In addition, mechanosensitive ion channels find in many sensory neurons do not function. Tactile-driven behaviors are also impaired in mutant mice, including touch-evoked pain caused by neuropathic injury. Belongs to the band 7/mec-2 family.