Involved in the biosynthesis of coumarins and furanocoumarins (FCs), natural products required for defense responses against attacks by predators with potential medical and agroindustrial usages such as anticoagulant, rodenticide and artificial vanilla substitutes (PubMed:29971079). Involved in angular furanocumarin biosynthesis. Converts (+)-columbianetin to angelicin (PubMed:19098286). Produces also some hydroxycolumbianetin as a by-product (PubMed:19098286). No activity with demethylsuberosin, (+)-marmesin, 5-hydroxymarmesin, psoralen, bergaptol, xanthotoxol, bergapten, xanthotoxin, isopimpinellin, cinnamic acid, 4-coumaric acid, 2-coumaric acid, ferulic acid, coumarin, herniarin, scopoletin, or umbelliferone (PubMed:19098286). The reaction mechanism is initiated by the abstraction of syn-C-3'-hydrogen (PubMed:19098286). (S)-columbianetin + O2 + reduced [NADPH--hemoprotein reductase] = acetone + angelicin + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] Not inhibited by (+)-marmesin, psoralen, 5- or 8-methoxypsoralen and angelicin. Optimum pH is 7.0. Optimum temperature is 27-30 degrees Celsius. Secondary metabolite biosynthesis. Belongs to the cytochrome P450 family.