Sialorphin may be involved in the modulation of mineral balance between at least four systems: kidney, bone, tooth and circulation. Submandibular gland peptide T is able to directly or indirectly down-regulate cardiovascular depression induced by septic shock (endotoxin stimuli), or anaphylactic challenge (nematode antigen sensitization). Sialorphin is an endogenous inhibitor of neprilysin. Inhibits the breakdown of Met-enkephalin and substance P in isolated tissue from the dorsal zone of the rat spinal cord. Has an analgesic effect when administered to rats by intravenous injection. Found in blood. Secreted from the salivary compartment into the blood circulation, rather than through absorption by the gastro-intestinal tract. Expressed predominantly in the acinar cells of the submandibular gland and to lesser extent in the prostate. By androgens; strongly. Several O-linked glycosylation sites might be present in the C-terminal part. SMR1 mRNA is about 1000 times more abundant in the submandibular gland of male than female.