Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. ATP + H2O = ADP + H(+) + phosphate Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (By similarity). Interacts directly with IKFZ1 in the NuRD complex. Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:9804427, PubMed:10204490, PubMed:15454082). Part of a complex containing ATR and HDAC2 (PubMed:10545197). Interacts with HDAC2; the interaction is direct (PubMed:12198550). Interacts with TRIM27 (PubMed:14530259). Interacts with ZGPAT; the interaction is direct (PubMed:19644445). Interacts with BCL6 (PubMed:15454082). Interacts with BRD4 (PubMed:21555454). Interacts with PCNT (PubMed:17626165). Interacts with SETX (PubMed:23149945). Interacts with HDAC1 (PubMed:27616479). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (PubMed:12198550). Interacts with the cohesin complex component RAD21; the interaction is direct (PubMed:12198550). Does not interact with PWWP2A and PWWP2B (By similarity). Associates with centrosomes in interphase. The disease is caused by variants affecting the gene represented in this entry. One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis. Belongs to the SNF2/RAD54 helicase family.