Transcription factor that regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). Shuttles between the cytoplasm and nucleus. Expressed in the developing eye. In 48h embryos, low levels in the developing eye. High levels in the branchial arch region and within the nasal epithelium. branchial arch region and in the developing pancreas.