Toll-related receptor which binds to the neurotrophins NT1 and spz5 (PubMed:10973475, PubMed:23892553). Essential for antiviral autophagy, it detects and binds to the vesicular stomatitis virus (vsv) following infection (PubMed:22464169). This role is likely to be independent of the canonical Toll, immune deficiency, and JAK-STAT signaling pathways (PubMed:22464169). Functions in olfactory circuit assembly by promoting synaptic partner matching between olfactory receptor neurons (ORN) axons and projection neurons (PN) dendrites partners in the antennal lobe (PubMed:25741726). Function in the Va1d ORNs is necessary and sufficient for correct targeting to their partner PN dendrites (PubMed:25741726). Also involved in the targeting of other classes of ORN axons (PubMed:25741726). Functions with Toll-6 to regulate motor axon targeting and neuronal survival in the central nervous system (CNS) (PubMed:23892553). May be an upstream component of the NF-kappa-B (rel) regulatory cascade (PubMed:23892553). Expressed in the fan-shaped body and the ellipsoid body, which are components of the locomotion center in the CNS (at protein level) (PubMed:23892553). In embryos, expressed in the ventral neurons, motor neurons and in the longitudinal interneuron axons (at protein level) (PubMed:23892553). May also be expressed in the motor neuron dendrites or possibly the glia (at protein level) (PubMed:23892553). Expressed 48 hours after puparium formation in the lateral glomeruli of the anterior and central regions of the antennal lobe, including the DA1, VA1d and VA1v glomeruli (at protein level) (PubMed:25741726). Expressed zygotically (PubMed:12617819). High levels of expression in embryos and pupae, and relatively low levels of expression in larvae and adults (PubMed:10973475). At germ band extension, expressed as 14 stripes in the embryo (PubMed:12617819). At germ band retraction, expressed in a subset of neurons in the CNS, the precursors of the leg imaginal disks and in the ventral epithelium of the large intestine (PubMed:12617819). Expressed in the posterior and anterior spiracles (PubMed:12617819). In stage 16 embryos, expression decreases and is mainly localized to the CNS (PubMed:12617819). Expressed in the proximal region of the wing imaginal disks, around the wing pouch and hinge regions (PubMed:21158756). Also expressed in the distal segments of the leg imaginal disks, with high levels of expression around the A-P border of the tarsal to tibia segments (PubMed:21158756). In larvae, detected in the fat body (PubMed:12617819). Up-regulated during vesicular stomatitis virus (VSV) infection. Mistargeting of VA1d ORN axons to a medial position (PubMed:25741726). No effect on the immune response to septic injury using a mixture of Gram-positive and Gram-negative bacteria; adults are able induce expression of antibacterial peptide genes (Drs, AttA, DptA and Mtk) and mount a proper innate immune response (PubMed:21158756). RNAi-mediated knockdown results in adults that are acutely sensitive to the vesicular stomatitis virus (vsv) (PubMed:22464169). Following infection with vsv adult survival is decreased, and adults show a dramatic increase in viral RNA production 6 days post vsv infection and viral replication 9 days post infection (PubMed:22464169). Reduced autophagy in adult fat body cells following vsv infection (PubMed:22464169). Starvation-induced autophagy is not affected (PubMed:22464169). Belongs to the Toll-like receptor family. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.