Sodium-dependent and purine-selective (PubMed:7775409, PubMed:8967974, PubMed:1315767). Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine) (PubMed:7775409, PubMed:8967974, PubMed:1315767). Accepts purine, analogs of purine nucleosides and uridine, and exhibits high affinity for adenosine (PubMed:7775409). adenosine(out) + Na(+)(out) = adenosine(in) + Na(+)(in) inosine(out) + Na(+)(out) = inosine(in) + Na(+)(in) guanosine(out) + Na(+)(out) = guanosine(in) + Na(+)(in) Na(+)(out) + uridine(out) = Na(+)(in) + uridine(in) Inhibited by formycin B, partially inhibited by purine analog ara-A. Expressed in liver (in bile canalicular membrane vesicles (CMV) but not in sinusoidal vesicles), jejunum, spleen and heart (PubMed:7775409). Also expressed in brain and skeletal muscle (PubMed:7775409). Not expressed in kidney, muscle and lung (PubMed:7775409). Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.