Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2) (By similarity). Binds HTATIP2/TIP30. Interacts with YLPM1. Forms a complex with ILF2, ILF3, YLPM1, KHDRBS1, RBMX and PPP1CA (By similarity). Expressed in both unfertilized and fertilized eggs during preimplantation development (at protein level) (PubMed:24268775). Detected in all blastmeres of morulae at 3 days post-coitum (dpc) (at protein level) (PubMed:24268775). Localizes to the pluripotent inner cell mass (ICM) of blastocysts at 4 dpc (at protein level) (PubMed:24268775). Expressed in many fetal tissues (PubMed:11113208). High expression in fetal heart and kidney (PubMed:11113208). Weak expression in fetal liver (PubMed:11113208). Contains one Leu-Xaa-Xaa-Leu-Leu (LxxLL) motif that is essential for the association with nuclear receptors.