Protein kinase that phosphorylates TP53, and thus induces TP53 repression of BIRC5 promoter (By similarity). May act as a corepressor of transcription factors (Potential). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Autophosphorylated. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. HIPK subfamily.