Catalyzes the dehalogenation of halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine, 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:34748729). Activity towards 2-iodophenol is weak (PubMed:34748729). 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH kcat is 1.6 min(-1) for the dehalogenation of 3-iodo-L-tyrosine (at pH 7.4 and 25 degrees Celsius) (PubMed:34748729). kcat is 27 min(-1) for the dehalogenation of 3-iodo-L-tyrosine (at pH 7.4 and 60 degrees Celsius) (PubMed:34748729). kcat is 0.84 min(-1) for the dehalogenation of 2-iodophenol (at pH 7.4 and 25 degrees Celsius) (PubMed:34748729). kcat is 6.5 min(-1) for the dehalogenation of 2-iodophenol (at pH 7.4 and 60 degrees Celsius) (PubMed:34748729). kcat is 27 min(-1) for the dehalogenation of 3-iodo-L-tyrosine (at pH 7.4 and 60 degrees Celsius) (PubMed:34748729). kcat is 5.1 min(-1) for the dehalogenation of 3-bromo-L-tyrosine (at pH 7.4 and 60 degrees Celsius) (PubMed:34748729). kcat is 2.9 min(-1) for the dehalogenation of 3-chloro-L-tyrosine (at pH 7.4 and 60 degrees Celsius) (PubMed:34748729). Homodimer. Belongs to the nitroreductase family.