Kappa-conotoxins bind and inhibit voltage-gated potassium channels. This toxin inhibits Kv1.2/KCNA2 and Kv1.6/KCNA6. Produces stiffening of body, limbs and tail when injected intracranially into mice. Expressed by the venom duct. The cysteine framework is XI (C-C-CC-CC-C-C). Has no effect on Kv1.3/KCNA3 channels. Belongs to the conotoxin I2 superfamily.