Catalyzes the oxidation of 2-deoxy-scyllo-inosamine (DOIA) with NAD(+) or NADP(+), forming 3-amino-2,3-dideoxy-scyllo-inosose (amino-DOI). 2-deoxy-scyllo-inosamine + NADP(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADPH 2-deoxy-scyllo-inosamine + NAD(+) = 3-amino-2,3-dideoxy-scyllo-inosose + H(+) + NADH Binds 2 Zn(2+) ions per subunit. Metabolic intermediate biosynthesis; 2-deoxystreptamine biosynthesis; 2-deoxystreptamine from D-glucose 6-phosphate: step 3/4. Antibiotic biosynthesis; paromomycin biosynthesis. Belongs to the zinc-containing alcohol dehydrogenase family. DOIA dehydrogenase subfamily.