Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3 (PubMed:19752190). It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere (By similarity). Interacts with CSRP3; possibly two molecules of CFL2 can interact with one molecule if CSRP3. Colocalizes with CSPR3 in the Z line of sarcomeres. Isoforms are identical at the level of the protein sequence. Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal. The disease is caused by variants affecting the gene represented in this entry. Belongs to the actin-binding proteins ADF family. Cofilin entry