Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. At 8.5 dpc, expressed in the foregut. At 9.5 dpc, expressed in the ventral mesencephalon and rhombencephalon. At 12.5 dpc, expressed in ventral midbrain, myotome and kidney. Mutants exhibited no phenotype in either head development or somitogenesis. Belongs to the shisa family.