Removes ADP-ribose from aspartate and glutamate residues in proteins bearing a single ADP-ribose moiety. Inactive towards proteins bearing poly-ADP-ribose. Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins. 2''-O-acetyl-ADP-D-ribose + H2O = acetate + ADP-D-ribose + H(+) 4-O-(ADP-D-ribosyl)-L-aspartyl-[protein] + H2O = ADP-D-ribose + H(+) + L-aspartyl-[protein] 5-O-(ADP-D-ribosyl)-L-glutamyl-[protein] + H2O = ADP-D-ribose + H(+) + L-glutamyl-[protein] alpha-NAD(+) + H2O = ADP-D-ribose + H(+) + nicotinamide Subject to product inhibition by ADP-ribose. Interacts with ADP-ribosylated PARP1. Recruited to DNA lesions, probably via mono-APD-ribosylated proteins. Expressed in the kidney. At 12.5 dpc, expressed in the neural tube and in the dorsal root and cranial ganglia. At 14.5 dpc, expressed in metanephric glomeruli, but not in the medullary region of the kidney, in the epithelium lining the gut, the stomach and the seminiferous tubules, as well as in lung. Expression is maintained in the dorsal root and cranial ganglia. In the cranial region, up-regulated in the epithelial and mesenchymal components of the tooth bud, in the epithelium lining the primitive nasal cavity, the vestibulocochlear and cochlear ducts and in the cranial ganglia. At 16.5 dpc, expression is maintained in kidney and lung. Detected in the papilla of the whisker follicle. In the eye, highly expressed in the cuboid epithelium of the lens and the inner nuclear (neuroblastic) layer of the retina. Expression begins in the brain, in particular the ventricular zone, and in the heart. At 18.5 dpc, expression is maintained in the brain, including the subventricular zone of striatum and olfactory lobe, the cortical plate, the cerebellar primordium and the inferior colliculus of the tectum. At this stage, the expression in the heart is 45 times lower than in the brain. At birth, still detectable in the metanephric glomeruli, but not in the adrenal gland.