Involved in the biosynthesis of prenylated phenolics natural products which contribute to the bitter taste of beer and display broad biological activities (Probable). Chalcone synthase that can use 4-coumaroyl-CoA to produce 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can, under specific conditions, spontaneously isomerize into naringenin (By similarity). 4-coumaroyl-CoA + 2 H(+) + 3 malonyl-CoA = 2',4,4',6'-tetrahydroxychalcone + 3 CO2 + 4 CoA Secondary metabolite biosynthesis; flavonoid biosynthesis. Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family.