The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Predominantly nuclear. Expressed in all tissues examined: highly expressed in testis and brain. Also expressed in heart, lung, liver, kidney, stomach and small intestine. Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Belongs to the nuclear hormone receptor family. NR3 subfamily.