By inhibiting Nav1.7/SCN9A sodium channel, may prevent signal transmission caused by tick penetration and the blood taken, allowing the tick to avoid discovery (PubMed:27407029). Weakly and specifically inhibits Nav1.7/SCN9A (IC(50)=1.6 uM) (PubMed:27407029). Significantly shifts the steady-state inactivation curve of the Nav1.7/SCN9A in the hyperpolarized direction (PubMed:27407029). Does not induce changes to I-V curve and conductance-voltage relationship (PubMed:27407029). Expressed by the salivary glands. Adopts a novel structural fold that may be an intermediate scaffold between disulfide-directed hairpin (DDH) and the inhibitor cystine knot motif (ICK). Shows very weak or no effect on human Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, hNav1.5/SCN5A, and Nav1.6/SCN8A sodium channels (PubMed:27407029). Does not show obvious effects on potassium and calcium channels (PubMed:27407029).