Interacts with DAZ1 and DAZL (By similarity). Interacts with IL17RB (By similarity). May interact with FAM168B (By similarity). Interacts with SOX6 (PubMed:14530442). Interacts with INCA1 (By similarity). Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm. Widely expressed. Highly expressed in brain. Between 11.5 dpc and 12.5 dpc it is specifically expressed in the developing heart. From 13.5 dpc, expression in the heart disappears, while it become strongly expressed in the brain. Up-regulated during adhesion and differentiation to beating cardiomyocytes. By serum stimulation. Ubiquitinated by SMURF2, leading to proteasomal degradation.