Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzD2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development (PubMed:23129634). Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) (PubMed:23129634, PubMed:12741825). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates (PubMed:12741825). (2S)-2-amino-4-deoxychorismate + H2O = (5S,6S)-6-amino-5-hydroxycyclohexa-1,3-diene-1-carboxyate + pyruvate kcat is 7.3 sec(-1) with 2-amino-2-deoxyisochorismate as substrate. kcat is 1.2 sec(-1) with chorismate as substrate. kcat is 0.2 sec(-1) with isochorismate as substrate. kcat is 0.02 sec(-1) with 4-amino-4-deoxychorismate as substrate. Antibiotic biosynthesis; phenazine biosynthesis. Homodimer. In liquid cultures (aerobic), phz2 operon is induced by quinolone signal via 2-heptyl-3-hydroxy-4-quinolone (PQS). In biofilm (microaerobic), phz2 operon is induced by quinolone signal via 4-hydroxy-2-heptylquinoline (HHQ), a precursor of PQS. Belongs to the isochorismatase family. The gene for this protein is part of the operon phzABCDEFG which is duplicated in P.aeruginosa. Cristallographic study (PubMed:12741825) has been arbitrarily placed in this entry (AC P0DPC1), because it is impossible to differentiate between the duplicate which has been chosen for the study, and because PhzD2 (AC P0DPC1) displays an important role in phenazine production and host infection.