Acts at E2F-responsive promoters as coregulator to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. May act as coactivator as well as corepressor of E2F1-TFDP1 and E2F4-TFDP1 complexes on E2F consensus binding sites, which would activate or inhibit E2F-target genes expression. Modulates fat storage by down-regulating the expression of key genes involved in adipocyte lipolysis, thermogenesis and oxidative metabolism. Interacts with XPO1; which mediates nuclear export. Interacts with TFDP1; modulates transactivation activity of TFDP1/E2F complexes (By similarity). Exported out of the nucleus via its NES in a XPO1-dependent manner. Once in the cytoplasm, is degraded by the proteasome (By similarity). Expressed in white and brown adipose tissue. Up-regulated by high fat diet in adipose tissue. Polyubiquitinated, which promotes proteasomal degradation. Resist development of obesity because of enhanced lipolysis and thermogenesis due, in part, to an increase in brown adipocytes number. On high fat diet (HFD), show reduced white adipose tissue (WAT) weight with smaller adipocyte size, improved glucose tolerance and insulin sensitivity with lower fasting glucose and insulin concentrations. Animals on HFD have higher and lower concentrations of adiponectin and leptin, respectively, compared to wild-type. They don't develop liver steatosis and have 57% less adipose tissue macrophage infiltration.