Inhibit human platelet aggregation induced by ADP, collagen, thrombin or the thromboxane analog U46619 in platelet suspension with IC(50) values of 66-267 nM. Acts by inhibiting fibrinogen interaction with platelet receptors GPIIb/GPIIIa (ITGA2B/ITGB3) (PubMed:9838213). It also inhibits angiogenesis in vivo and in vitro by blocking integrin alpha-V/beta-3 (ITGAV/ITGB3) of endothelial cells and by inducing apoptosis (PubMed:9787163). Monomer (disintegrin). Expressed by the venom gland. Does not inhibit the binding of specific monoclonal antibodies to alpha-2/beta-1 (ITGA2/ITGB1), alpha-3/beta-1 (ITGA3/ITGB1), and alpha-5/beta-1 (ITGA5/ITGB1) integrins. The disintegrin belongs to the short disintegrin subfamily. Belongs to the venom metalloproteinase (M12B) family. P-II subfamily. P-IIa sub-subfamily. Lys-Phe-Leu-Lys residues at positions 15-18 are predicted by comparison with orthologs and according to the data of amino acid composition. Pyroglutamate residue at position 1 has been predicted by comparison with orthologs and because the pyroglutamate aminopeptidase was used to allow sequencing. It is noteworthy that the theoritical mass of the peptide does not correspond to the measured mass of 5241 Da.