Interacts with host ITCH; this interaction probably mediates ITCH degradation. Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. Contains one L domain: a PPXY motif which is involved in the interaction with ITCH, a member of the NEDD4 family. The vaccine strains V-Oka, VariVax, and VarilRix harbor a mutation in the stop codon that extends the ORF by 92 aminoacids. Belongs to the varicellovirus ORF0 protein family.