Chemotactic for CESS B-cells and THP-1 monocytes, but not T-cells. Highly expressed in brain, lung, ovary, muscle and in kidney and liver parenchyma, and at lower levels in bone marrow. The destruction box (D-box) acts as a recognition signal for degradation via the ubiquitin-proteasome pathway. Ubiquitinated, followed by degradation by the proteasome. Belongs to the intercrine alpha (chemokine CxC) family.