Probable component of the nuclear pore complex (NPC) (By similarity). Involved in maintaining the localization of another nucleoporin Mtor to the nuclear envelope of early meiotic female germline cells (PubMed:21521741). It is not involved in recruiting the nucleoporins Mtor, Nup107, Nup153 and FG-containing nucleoporins to the NPC (PubMed:21521741). An essential component of the GATOR subcomplex GATOR2 which functions as an activator of the amino acid-sensing branch of the TORC1 signaling pathway (PubMed:27166823, PubMed:23723238). The two GATOR subcomplexes, GATOR1 and GATOR2, regulate the TORC1 pathway in order to mediate metabolic homeostasis, female gametogenesis and the response to amino acid limitation and complete starvation (PubMed:27166823, PubMed:23723238, PubMed:25512509). GATOR2 activates the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex, controlling the switch to cell proliferation growth under nutrient replete conditions and growth during female oocyte development (PubMed:21521741, PubMed:25512509, PubMed:23723238, PubMed:27166823). This component is required for activating TORC1 specifically in germline cells to promote cell growth and maintain the oocyte fate, probably influences the organization and/or function of microtubules within ovarian cysts, and promotes accumulation of another GATOR2 complex member mio in germline and somatic tissues (PubMed:27166823, PubMed:23723238, PubMed:25512509, PubMed:21521741). GATOR1 and GATOR2 act at different stages of oogenesis to regulate TORC1 in order to control meiotic entry and promote oocyte growth and development (PubMed:25512509). After exactly four mitotic cyst divisions, the GATOR1 complex members (Iml1, Nprl2 and Nprl3) down-regulate TORC1 to slow cellular metabolism and promote the mitotic/meiotic transition (PubMed:25512509). At later stages of oogenesis, the mio and Nup44A components of the GATOR2 complex inhibit GATOR1 and thus activate TORC1 to promote meiotic progression, and drive oocyte growth and development (PubMed:21521741, PubMed:25512509). In addition to its role in the regulation of the TORC1 complex, functions independently of TORC1 to prevent the inappropriate accumulation of autolysosomes in germline tissues (PubMed:27166823). Probable component of the nuclear pore complex (NPC) (By similarity). Component of the GATOR complex consisting of mio, Nup44A/Seh1, Im11, Nplr3, Nplr2, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Within the GATOR complex, probable component of the GATOR2 subcomplex which is likely composed of mio, Nup44A/Seh1, Wdr24, Wdr59 and Sec13 (PubMed:27166823). Interacts with mio (PubMed:21521741). Interacts with Wdr24 (PubMed:27166823). Enriched on the nuclear envelope of nurse cells, oocytes and syncytial embryos (PubMed:21521741). In egg chambers detected in lysosomes and autolysosomes of both fed and starved females (PubMed:25512509). Expressed in ovarian cysts. Adults develop normally, however females display ovarian defects and reduced fertility likely due to the significant decrease in TORC1 activity within the germline cells (PubMed:21521741, PubMed:25512509). Ovarian defects include adherent cyst divisions due to mitotic delay, accumulation of autolysosomes resulting in reduced number of egg chambers and reduced number of eggs laid per female per day (PubMed:21521741, PubMed:25512509). Spindle defects and mitotic delay results in egg chambers often containing 16 polyploid nurse cells and no oocyte because the oocyte enters the endocycle and develops as a polyploid nurse cell (PubMed:21521741). In early meiotic germline cells, the nucleoporin Mtor is displaced from the nuclear envelope to the nucleoplasm, most notably as cysts enter the meiotic cycle beginning in R2a of the germarium (PubMed:21521741). However, there is no effect on the recruitment of Mtor or other nucleoporins (Nup107, Nup153, Mtor and FG-containing nucleoporins) to the nuclear pore complex (PubMed:21521741). In contrast, somatic tissues do not display any obvious developmental defects; there is no decrease in TORC1 activity and no accumulation of autolysosomes in the larval fat body (PubMed:25512509, PubMed:21521741, PubMed:27166823). Increasing TORC1 activity in the mutant female germline via RNAi-mediated knockdown of the GATOR1 subcomplex members Nprl2, Nprl3, Iml1 or knockdown of Tsc1 rescues the ovarian defects (PubMed:25512509). However, knockdown of Nprl2 or Nprl3 does not rescue the accumulation of autolysosomes (PubMed:27166823). Belongs to the WD repeat SEC13 family.