Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins (By similarity). Regulates endosomal traffic in polarized epithelial cells such as the vulval precursor cells and intestinal cells. Thought to act as a negative regulator of lin-12 activity in vulval precursor cells. May have a role in the internalization process from basolateral surface of polarized epithelial cells. Interacts with RII subunit of PKA. Expressed in vulval precursor cells and rectal epithelia in L2 and L3 larvae. In L4 larvae, expression is seen in intestinal epithelial cells. Worms lacking sel-2 exhibit a multivulva phenotype when combined with loss of lin-12. Belongs to the WD repeat neurobeachin family.