May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. Associated with microtubules. Expression begins at S phase, accumulates in late S/G2 phase and disappears in G1 phase. By p53 when exposed to different DNA damaging agents, including gamma irradiation and chemotherapeutic drugs. Phosphorylated in mitosis.