DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G, U/A, U/C or U/T base pair. Can also excise ethenocytosine and hypoxanthine from double-stranded DNA. Product inhibited by AP-site containing dsDNA but not by uracil. Thermo-tolerant. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. Extended N-terminus.