DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation. Interacts with phosphorylated RET. In contrast to other DOK proteins, it does not interact with RASGAP. Specifically expressed in the brain, with a high specificity for neurons. In 12.5 dpc and 13 dpc embryos, it is expressed in the central nervous system, e.g. in the neural tube, the dorsal root and the cranial ganglion. PTB domain mediates receptor interaction. Phosphorylated on tyrosine residues in response to insulin, IGF1 and GDNF. Belongs to the DOK family. Type B subfamily.