Bifunctional enzyme that catalyzes the fourth and fifth sequential steps of CoA biosynthetic pathway. The fourth reaction is catalyzed by the phosphopantetheine adenylyltransferase, coded by the coaD domain; the fifth reaction is catalyzed by the dephospho-CoA kinase, coded by the coaE domain. May act as a point of CoA biosynthesis regulation. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate 3'-dephospho-CoA + ATP = ADP + CoA + H(+) Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 5/5. Monomer. The protein is mainly present in the mitochondrial matrix, probably anchored to the inner mitochondrial membrane, but this protein is also present in cell lysate. Widely expressed with highest levels in kidney and lowest levels in colon, lung, intestine, and spleen. In the central section; belongs to the eukaryotic CoaD family. Truncated N-terminus.