This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities (By similarity). an [RNA] containing cytidine + H2O = an [RNA]-3'-cytidine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. an [RNA] containing uridine + H2O = an [RNA]-3'-uridine-3'-phosphate + a 5'-hydroxy-ribonucleotide-3'-[RNA]. Interacts with and forms a tight 1:1 complex with RNH1. Dimerization of two such complexes may occur (By similarity). Matrix of eosinophil's large specific granule. Belongs to the pancreatic ribonuclease family.