Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position and a nonpolar amino acid at the N-terminal position. Also catalyzes the hydrolysis of toxic organophosphorus cholinesterase-inhibiting compounds including nerve gases such as diisopropylfluorophosphate (DFP), O-isopropyl methylphosphonofluoridate (sarin), O-pinacolyl methylphosphonofluoridate (soman), and O-cyclohexyl methylphosphonofluoridate. Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro. diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H(+) Binds 2 manganese ions per monomer. Optimum pH is 7.5. Optimum temperature is 40 degrees Celsius. The N-terminus is blocked. Belongs to the peptidase M24B family.