Acts as a negative growth regulator via p53-mediated apoptosis pathway. Regulates formation of degradative autolysosomes during autophagy (By similarity). Interacts with BCL2. Found in all the examined tissues. High expression was found in liver, skeletal muscle, pancreas, kidney heart and to a lesser extent in brain, placenta and lung. By etoposide treatment, induction requires p53. Etoposide induces DNA damage in cells by inhibiting DNA topoisomerase II, and ultimately causes apoptotic cell death. Belongs to the EI24 family. Extended N-terminus. Extended N-terminus. Extended N-terminus. Extended N-terminus.