Required for the function of many mechanoreceptors. Modulate mechanotransduction channels and acid-sensing ion channels (ASIC) proteins. Potentiates PIEZO1 and PIEZO2 function by increasing their sensitivity to mechanical stimulations. Homodimer. Interacts with PIEZO1 and PIEZO2. Detected in lipid rafts. Belongs to the band 7/mec-2 family.