Secreted effector that exhibits strong cell death suppression activity and suppresses cell death induced by a variety of effectors including CRN63, Avh241 and Avr3a (PubMed:26546319). Protects host plants from biotic and abiotic stresses such as salinity and drought by up-regulation of many defense-related genes, including ABC transporters, Cytochrome P450 monooxygenases and receptor-like kinases (RLKs) (PubMed:26546319). Enhances also resistance to Phytophtora pathogens (PubMed:26546319). The CRN proteins have modular architectures that include a signal peptide, a conserved N-terminus, and highly diverse C-terminal domains. The conserved CRN N-terminus harbors a distinct LXLFLAK motif, which is followed by the conserved DWL domain. A highly conserved HVLVXXP motif marks the end of the CRN N-terminal domains and forms a junction where diverse C-terminal domains are fused. The conserved CRN N-terminus mediates the translocation into the plant host cells. Belongs to the Crinkler effector family.