Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins. Protein modification; protein ubiquitination. Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1, SKP1B/ASK2, ASK3, ASK9, ASK11, ASK12, ASK13, ASK14, ASK16 and ASK18. The F-box is necessary for the interaction with ASK proteins.