May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability. Interacts with PTPNS1. Part of a complex consisting of SKAP2, FYB1 and PTPNS1. Part of a complex consisting of SKAP2, FYB1 and LILRB3. Interacts with LAT, GRB2, PTK2B, and PRAM1. May interact with actin. May interact with FYN, HCK and LYN. Interacts with FASLG (By similarity). The SH3 domain interacts with FYB1 and PTK2B. Belongs to the SKAP family.