G-protein coupled receptor for cannabinoids (By similarity). Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissue (By similarity)s. Regulates cellular respiration and energy production in response to cannabinoids (By similarity). Signaling typically involves reduction in cyclic AMP (By similarity). Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity). Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity). Palmitoylation at Cys-417 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits. Belongs to the G-protein coupled receptor 1 family.