Involved in the biosynthesis of labdane-type diterpenoid including cleroda-dienols, and peregrinol lactones and furan derivatives, dopaminergic diterpenoids that can bind to dopamine receptors in the human pituitary gland, have probably ability to lower prolactin levels, and are used to treat menstrual cycle disorders (e.g. premenstrual syndrome and mastodynia) (Probable). Terpene synthase that produces kolavenyl diphosphate from geranylgeranyl diphosphate (GGPP) (PubMed:29315936). (2E,6E,10E)-geranylgeranyl diphosphate = (+)-kolavenyl diphosphate Secondary metabolite biosynthesis; terpenoid biosynthesis. Mostly expressed in trichomes of leaves and fruits. The Asp-Xaa-Asp-Asp (DXDD) motif is important for the catalytic activity, presumably through binding to Mg(2+). Belongs to the terpene synthase family.