Expression is induced during oxidative stress. Plays an essential, SCF-independent, role in the stress response to hydrogen peroxide for survival, by negatively regulating ergosterol synthesis via direct binding to the squalene synthase erg9. Component of the E3 ubiquitin ligase Skp1-Cullin-1-F-box (SCF) complex. Interacts with skp1, cul1 and erg9. Associated with vesicle-like and endoplasmic reticulum (excluding a nuclear rim) structures. Expression is induced during oxidative stress.