Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). The SCF(CCNF) E3 ubiquitin-protein ligase complex is an integral component of the ubiquitin proteasome system (UPS) and links proteasome degradation to the cell cycle (By similarity). Mediates the substrate recognition and the proteasomal degradation of various target proteins during G2 phase involved in the regulation of cell cycle progression and in the maintenance of genome stability (By similarity). May play a role in motor neuron development and axonal outgrowth (PubMed:28444311). Component of the SCF(CCNF) complex. Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Localizes to the nucleus in G2 phase. Expressed in the brain. Initially ubiquitous expression at 12 hours post-fertilization (hpf), then strongly expressed in the central nervous system by 48 hpf (PubMed:28444311). Strongly expressed in the brain up to 5 days post-fertilization (dpf) (PubMed:28444311). Ongoing expression in whole brain tissue beyond 5 dpf into adulthood (PubMed:28444311). The nuclear localization signals mediate the localization to the nucleus. The D box motifs (amino acid sequence RxxL) are involved in substrate binding, and may be ubiquitinated. Belongs to the cyclin family. Cyclin AB subfamily.