Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrE may be responsible for anchoring the complex to the membrane. coenzyme B + coenzyme M + methanophenazine = coenzyme M-coenzyme B heterodisulfide + dihydromethanophenazine Binds 2 heme b (iron(II)-protoporphyrin IX) groups per subunit. Cofactor metabolism; coenzyme M-coenzyme B heterodisulfide reduction; coenzyme B and coenzyme M from coenzyme M-coenzyme B heterodisulfide: step 1/1. The dihydromethanophenazine:CoB--CoM heterodisulfide reductase is composed of two subunits; HdrD and HdrE. Methanophenazine seems to mediate electron transfer from F(420)H(2) dehydrogenase to the dihydromethanophenazine:CoB--CoM heterodisulfide reductase. Belongs to the HdrE family.