Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B, FYB1. Colocalizes with FYB1 at cell-cell contacts in podocytes. Expressed in adult brain, fetal brain, cerebellum, heart, lung, prostate and thyroid. Belongs to the TMEM47 family.