N-acetyltransferase that acetylates histone H4 at 'Lys-8'. Also acetylates polyamines like putrescine, spermidine and spermine (PubMed:23775086). Acts on a wide range of D-amino acids. Catalyzes the N-acetylation through an ordered bi-bi mechanism, in which acetyl-CoA is the first substrate to be bound and CoA is the last product to be liberated (PubMed:15375647). D-amino acids are toxic for the cell and their N-acetylation, preceding removal from cells, plays an important role in detoxification of D-amino acids (PubMed:10600387, PubMed:16362288). a D-alpha-amino acid + acetyl-CoA = an N-acetyl-D-amino acid + CoA + H(+) acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] Autoacetylates in an intermolecular reaction. Present with 1200 molecules/cell in log phase SD medium. Belongs to the acetyltransferase family. GNAT subfamily. Extended N-terminus. Extended N-terminus.