Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. This protein regulates phospholipase A2 activity. It seems to bind from two to four calcium ions with high affinity. Found in the cilium, nucleus and basolateral cell membrane of ciliated cells in the tracheal endothelium. Found in the cytoplasm of type II pneumocytes and alveolar macrophages. A pair of annexin repeats may form one binding site for calcium and phospholipid. Phosphorylated by protein kinase C and epidermal growth factor receptor/kinase. The N-terminus is blocked. In pigeons, two isoforms of annexin-I are encoded by the differentially regulated genes CP35 and CP37. Belongs to the annexin family.