Together with the closely related MLP1, involved in the structural and functional organization of perinuclear chromatin (PubMed:10638763). MLP1/MLP2 associate with the nuclear pore complex and form filamentous structures along the nuclear periphery (PubMed:10085285, PubMed:24152732, PubMed:10617624). Has a role in the localization of Esc1 to nucleolar regions (PubMed:24152732). Together with MLP1, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing (PubMed:11862215). MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring (PubMed:12490156). Plays a role in the incorporation of components into the spindle pole body (PubMed:10617624, PubMed:14718167, PubMed:16027220). Involved in double-strand break repair, probably also mediated by the YKU70/YKU80 (HDF1/HDF2) heterodimer (PubMed:10638763, PubMed:14718167, PubMed:16027220). Component of the nuclear complex (NPC) (PubMed:24152732). NPC constitutes the exclusive means of nucleocytoplasmic transport (PubMed:24152732). NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope (PubMed:24152732). Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:24152732). Interacts with NUP60 and NIC96, which tether it to the nuclear pore complex. Component of the spindle pole body core in which it interacts directly with SPC110, SPC42 and SPC29. Also interacts with YKU70 (HDF1) and MLP1. Nuclear periphery, excluded from nuclear envelope adjacent to nucleolus. Present with 2770 molecules/cell in log phase SD medium.