Effector that is required for full virulence (PubMed:24130484). Targets host NTP1 and NTP2 transcription factors and prevents their pathogen-associated molecular pattern (PAMP)-triggered re-localization from the endoplasmic reticulum into the nucleus, where they contribute to prevent disease progression by P.infestans (PubMed:24130484). Interacts with the C-terminal portions the ER-associated potato NAC transcription factors NTP1 and NTP2. Expression is induced during host plant infection. The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate. Decreases virulence on both potato and Nicitiana benthamiana. Belongs to the RxLR effector family.