Required for rRNA maturation. Binds IPO9 with high affinity (PubMed:11823430). Interacts with NEK6 (PubMed:20873783). Interacts with DESI2 (PubMed:28483520). Interacts with IPO5, IPO7 and KPNB1; these interactions may be involved in RPS7 nuclear import for the assembly of ribosomal subunits (PubMed:9687515). Although RPS7 is functional within the cytoplasm, the assembly of ribosomal subunits occurs in the nucleus. RPS7 nuclear import is mediated by IPO5/RanBP5, IPO7/RanBP7, KPNB1/importin-beta or TPNO1/Trn (PubMed:9687515). Colocalizes with NEK6 in the centrosome (PubMed:20873783). Phosphorylated by NEK6. Ubiquitinated. Deubiquitinated by DESI2, leading to its stabilization. The disease is caused by variants affecting the gene represented in this entry. Belongs to the eukaryotic ribosomal protein eS7 family.