May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress. Interacts with ERLIN2. Detected in brain, spinal cord, lung, liver and kidney. Lethality typically occurs several days after birth, associated with motor neuron deficiency and paresis. Belongs to the membralin family.