Non-amphipathic mildly cationic alpha-helical antimicrobial peptide with potent activity against Gram-positive (including methicillin-resistant Staphylococcus aureus (MRSA)) and Gram-negative bacteria, and some fungi, as well as against Trypanosoma and Leishmania (both promastigote and amastigote forms) (PubMed:23116712). Strongly and selectively perturbs anionic bilayer membranes by interacting with the polar head groups and acyl region of the phospholipids, with formation of regions of two coexisting phases, one phase rich in peptide and the other lipid-rich (PubMed:23116712). Shows low hemolytic activity (LC(50)=44 uM) and a low toxicity for human monocytes THP-1 and THP-1-derived macrophages (PubMed:23116712). Is not toxic to human hepatoma-derived cells (PubMed:23116712). Deeply inserts into the lipid bilayer. Belongs to the frog skin active peptide (FSAP) family. Temporin subfamily.