Converts 15-cis-phytoene into all-trans-lycopene via the intermediary of all-trans-phytofluene, all-trans-zeta-carotene and all-trans-neurosporene, by the introduction of four double bonds. 15-cis-phytoene + 4 A = 4 AH2 + all-trans-lycopene Inhibited by NAD and NADP. Carotenoid biosynthesis; lycopene biosynthesis. Belongs to the carotenoid/retinoid oxidoreductase family.