Sugar isomerase that catalyzes the reversible isomerization of D-lyxose to D-xylulose (PubMed:34422783). Is highly specific for the substrate D-lyxose, showing less than 2% activity towards mannose and other substrates reported for lyxose isomerases (PubMed:34422783). D-lyxose = D-xylulose Shows highest activity with Mn(2+). The Mn(2+) ions can be effectively replaced by Co(2+) ions. Shows less activity with other divalent metal ions such as Fe(2+), Ca(2+) and Mg(2+). Optimum temperature is higher than 95 degrees Celsius. Retains 60% of its activity after 60 min incubation at 80 degrees Celsius. Homodimer; disulfide-linked (PubMed:34422783). Stabilized by a disulfide bond between the two monomers of the dimeric enzyme and increased hydrophobicity at the dimer interface (PubMed:34422783). High substrate specificity, thermostability and solvent tolerance make this lyxose isomerase enzyme a good candidate for potential industrial applications. Belongs to the D-lyxose ketol-isomerase family.