DNA-dependent ATPase that plays a role in chromatin remodeling. Regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. Activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2. ATP + H2O = ADP + H(+) + phosphate Interacts with NFE2L2; involved in activation of the transcription (By similarity). May interact with PPARA (PubMed:12189208). Enriched at sites of mRNA synthesis. Widely expressed. Belongs to the SNF2/RAD54 helicase family.