Has a role in alternative splicing and transcription regulation (PubMed:29522154). Involved in both constitutive and alternative pre-mRNA splicing. May have a role in the recognition of the 3' splice site during the second step of splicing. Interacts (via Arg/Ser-rich domain) with LUC7L3, RBM39 and RSF1. Shuttles between the nucleus and cytoplasm. Widely expressed. Expressed in brain, spinal cord, cerebellum. Phosphorylated. The disease is caused by variants affecting the gene represented in this entry.