Exhibits vaccine potential. Immunogenicity is demonstrated in BALB/c mice. Immunization with this protein induces a significant number of CD8+ T cells and a strong Th1-type response, with high gamma interferon (IFN-gamma) and low interleukin-4 responses, and activation of the bactericidal activity of macrophages. Identified T-cell epitopes may contribute to immunity against tuberculosis if included in a vaccine. Was identified as a high-confidence drug target. Belongs to the mycobacterial PPE family. Was originally thought to be a dihydrofolate reductase.