Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Interacts with F-actin (By similarity). Interacts with ANKRD54. Interacts with KBTBD10 (By similarity). Associated with the F-actin rich cortical cytoskeleton. Widely expressed with highest levels in mucosal tissues throughout the gastrointestinal tract as well as in heart, lung, liver, kidney, adrenal and smooth muscle. Lowest level is observed in skeletal muscle. Phosphorylated on serine residues after stimulation with histamine.