Zinc metalloprotease that has fibrinogenolytic and hemorrhagic activities. It induces apoptosis in vascular endothelial cells (VEC), without degrading extracellular matrix (it cannot cleave collagen) or inhibiting adhesion of VEC. VAP1-induced apoptosis is inhibited by antibodies for integrin alpha-3, alpha-6, beta-1 and CD9. Apoptosis is accompanied by severe cell fragmentation, which is controlled by caspases. Binds 1 zinc ion per subunit. Inhibited by EDTA and EGTA, but not by PMSF. Homodimer; disulfide-linked. Expressed by the venom gland. The N-terminus is blocked. LD(50) is 0.3 ug/ml against vascular endothelial cells in culture. Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIc sub-subfamily.