Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. Antibiotic biosynthesis; phenazine biosynthesis. In liquid cultures (aerobic), phz2 operon is induced by quinolone signal via 2-heptyl-3-hydroxy-4-quinolone (PQS). In biofilm (microaerobic), phz2 operon is induced by quinolone signal via 4-hydroxy-2-heptylquinoline (HHQ), a precursor of PQS. Belongs to the PhzA/PhzB family.