Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics. a carboxylic ester + H2O = a carboxylate + an alcohol + H(+) Expressed in liver, colon and small intestine. N-glycosylated. Belongs to the type-B carboxylesterase/lipase family.