Plays a key role in glycolysis and gluconeogenesis. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Homotetramer. Expressed in roots, and at low levels in rosettes leaves, cauline leaves, stems and flowers. Down-regulated by oxidative stress (PubMed:12492832). Induced by fructose and sucrose (PubMed:22561114). Down-regulated by abiotic stresses (PubMed:22561114). Can be trimethylated at Lys-387 by LSMT-L, but the trimethylation has no effect in vitro. S-glutathionylated. Belongs to the class I fructose-bisphosphate aldolase family.