Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway (PubMed:21448132). In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes (PubMed:21448132). Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway (PubMed:21448132). Facilitates the association of the exosome complex with the SKI complex. Interacts with the SKI complex. Associates with SKI complex; the interaction with SKIV2L is direct (PubMed:28204585). Associates with the exosome complex; the interaction with EXOSC3 is direct (PubMed:28204585). Detected in heart, brain, placenta, liver, muscle, kidney and pancreas. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family.