Cyanamide hydratase involved in the detoxification and/or utilization of cyanamide, a toxic nitrile compound distributed widely in the environment. urea = cyanamide + H2O Homohexamer. Expression is induced by DNA-damaging agents such as methyl methanesulfonate (MMS) or dimethyl sulfate (DMS) (PubMed:18485869, PubMed:25847245). Massively induced by cyanamide (PubMed:25847245). The double deletion of DDI2 and DDI3 compromizes cellular resistance to cyanamide by impairing its metabolization. DDI2 and DDI3 are duplicated genes located on different chromosomes, with identical ORF sequences and only one nucleotide difference in their promoter (up to 1 kb) regions. Belongs to the cyanamide dehydrase family.