Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane. Plays a critical role in central nervous system development and function. Interacts with CAMSAP1 (PubMed:24117850). Interacts with ANK2 (PubMed:15262991, PubMed:34211179). Interacts with CPNE4 (via VWFA domain) (By similarity). Like erythrocyte spectrin, the spectrin-like proteins are capable to form dimers which can further associate to tetramers (By similarity). Can form heterodimers with SPTAN1 (PubMed:34211179). Isoform Short cannot bind to the axonal protein fodaxin. Colocalizes with ANK2 in a distinct intracellular compartment of neonatal cardiomyocytes. Isoform 2 is present in brain, lung and kidney (at protein level). The disease is caused by variants affecting the gene represented in this entry. Belongs to the spectrin family. Extended N-terminus.