Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development. Binds DNA. Expression is likely to be restricted to bone. Found in parietal bone. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry. Belongs to the paired homeobox family. Extended N-terminus.