GTP-hydrolysis activating protein (GAP) for small GTPase RAB22A, converting active RAB22A-GTP to the inactive form RAB22A-GDP (By similarity). Plays a role in endocytosis and intracellular protein transport. Recruited by ANK2 to phosphatidylinositol 3-phosphate (PI3P)-positive early endosomes, where it inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (PubMed:27718357). Interacts (via Rab-GAP TBC domain) with ANK2 (via death domain). Colocalizes on endosomes partially with EEA1 (By similarity). Colocalizes and cotransports on motile vesicles with ANK2 (PubMed:27718357). Expressed in embryonic heart and liver, and in hemopoietic cells (PubMed:10585558). Expressed in the corpus callosum in the central nervous system (CNS) and costameres in skeletal muscle at postnatal day (PND) 30 (PubMed:27718357). The arginine and glutamine fingers are critical for the GTPase-activating mechanism, they pull out Rab's 'switch 2' glutamine and insert in Rab's active site. Truncated N-terminus. Contaminating sequence. Potential poly-A sequence.