May function as a signal transduction protein involved in the differentiation of fibroblasts into adipocytes and possibly other cell types. Plays a role in ciliogenesis (By similarity). Posseses phosphatidylinositol 4,5-bisphosphate-dependent GTPase-activating protein activity for ARF1 (ADP ribosylation factor 1) and ARF5 and a lesser activity towards ARF6. May coordinate membrane trafficking with cell growth or actin cytoskeleton remodeling by binding to both SRC and PIP2. Activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2). Homodimer. Interacts with SRC and CRK. Interacts with RAB11FIP3. Interacts with PTK2B/PYK2. Interacts with REPS2; the interaction is direct (PubMed:12149250). Predominantly cytoplasmic. Partially membrane-associated. Expressed in all tissues examined but a most abundant expression was found in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. The PH domain most probably contributes to the phosphoinositide-dependent regulation of ADP ribosylation factors. Phosphorylated on tyrosine residues by SRC. Extended N-terminus. Extended N-terminus.