Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Tightly binds to CoA, which is presumably a feedback inhibitor (PubMed:21527250). Potently inhibited by D-amethopterin, which simultaneously occupies the 4'-phosphopantetheine- and ATP-binding sites; following treatment with D-amethopterin, H.pylori exhibits morphological characteristics associated with cell death, showing that D-amethopterin displays antimicrobial activity (PubMed:24040220). Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Homohexamer. Belongs to the bacterial CoaD family.