Molecular adapter that recruits protein complexes required for cilium assembly and function to the cilium basal body (PubMed:19852954). Required for establishment of left-right asymmetry during embryogenesis (PubMed:19852954). Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals (PubMed:15115751). Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo (PubMed:15198976). In the cytoplasm, it is localized in large vesicles. These vesicles correspond to lysosomes and/or endosomes. Can shuttle between the cytoplasm and the nucleus in a manner correlated with Hh activity. Expressed throughout the embryo starting at 12 hours. Defects are a cause of reduced expression of Hh target genes in the ventral neural tube, similar to the phenotype seen in zebrafish mutants known to affect Hh signaling (PubMed:15115751, PubMed:15198976). Reduced cilium number in pronephric duct and Kupffer's vesicle (PubMed:19852954). Defects in left/right asymmetry, characterized by abnormal heart location on right or center of body (PubMed:19852954). Belongs to the DZIP C2H2-type zinc-finger protein family.