Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Isoform 2 interacts with the sarcomeric proteins, MRLC2, MYOM1 and ENO3. Isoform 1 is only expressed in the brain. Isoform 2 is ubiquitously detected with highest expression in skeletal muscle and detected in myocardial myofibrils. Variant Val-7 and Val-9 are detected in the brain only. By Hepatitis C virus core protein. The disease is caused by variants affecting the gene represented in this entry. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.