Prevents infected cell apoptosis induced by the host immune system. May act by down-regulating host TRAIL receptors. May act in complex with E3 RID alpha and beta. May play a role on cellular apoptosis regulation in the ER. Interacts with E3 RID alpha and E3 RID beta. Only 1 of 3 three potential glycosylation sites is glycosylated. Oligosaccharides are not processed from high mannose to the complex type because the protein is retained in the endoplasmic reticulum. Belongs to the adenoviridae E3-CR1 family.