Insecticidal neurotoxin that reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN) and inhibits inactivation of insect sodium channels (Nav) (By similarity). Inhibits glutamate uptake in rat brain synaptosomes (PubMed:14757211). In vivo, induces immediate excitatory effects when injected intrathoracically in houseflies and cockroaches (PubMed:14757211). Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. LD(50) is 20 ng/house fly. Has no effect when intracerebroventricularly injected into mice. Belongs to the neurotoxin 03 (Tx2) family. 05 subfamily.