Could play pivotal roles in cell cycle and DNA regulation (PubMed:19150984). Involved in innate immune defense against viruse by positively regulating the viral dsRNA receptors DDX58 and IFIH1 signaling pathways (PubMed:22328336). Involves in NOD2- and NOD1-mediated responses to bacteria suggesting a role in innate antibacterial immune pathways too (PubMed:23711367). Target of enterovirus 71 which is the major etiological agent of HFMD (hand, foot and mouth disease) (PubMed:17276651). Could play a central role for the formation and/or maintenance of the blood vessels of the circulation system (By similarity). Interacts (via N-terminus) with NOD2. Interacts with CDK2, MCM3, MCM5, MCM7, CDC6 and PCNA. Interacts with MAVS and IFIH1. Interacts (via the second ankyrin repeat cluster) with DDX58. (Microbial infection) Interacts with enterovirus 71/EV71 capsid protein VP1. Detected around the nucleolus. Localized on chromatin in a cell cycle-dependent manner. Ubiquitously expressed. Phosphorylated by CDK2. The disease is caused by variants affecting the gene represented in this entry. Contaminating sequence. Potential poly-A sequence. Truncated N-terminus. Contaminating sequence. Potential poly-A sequence.