alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate Binds 1 Fe cation per subunit. Inhibited by mannose 6-phosphate, fructose 1-phosphate and fructose 1,6-bisphosphate. Its activity is also inhibited by Cobalt (II) ions < EDTA < nickel (II) ions < zinc (II) ions << cadmium (II) ions < copper (II) ions. Sodium and potassium ions and manganese ions show little or no effect on activity. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. Homodimer. Belongs to the archaeal-type GPI family.