EsxG, in complex with EsxH, disrupts ESCRT function and impairs host phagosome maturation, thereby promoting intracellular bacterial growth. The complex acts by interacting, via EsxH, with the host hepatocyte growth factor-regulated tyrosine kinase substrate (HGS/HRS), a component of the ESCRT machinery. EsxG stabilizes EsxH in the host cytosol. Forms a tight 1:1 complex with EsxH. Secreted via the ESX-3 / type VII secretion system (T7SS). To improve expression in E.coli the proteins were cloned as a single protein in the order esxH-esxG with a cleavable thrombin tag (PubMed:19854905). Belongs to the WXG100 family. CFP-10 subfamily.