Phosphorylates elongation factor-2 (eEF-2) at two threonine residues that are conserved in all eukaryotes and are located within a GTP-binding domain (PubMed:9144159). Calcium(2+)/calmodulin dependent activity (PubMed:9144159). Inactivates eEF-2 by catalyzing its phosphorylation (PubMed:9144159). eEF-2 catalyzes the movement of the ribosome along mRNA during translation in eukaryotic cells (PubMed:9144159). [translation elongation factor 2] + ATP = [translation elongation factor 2]-phosphate + ADP + H(+) Calcium(2+)/calmodulin dependent activity (PubMed:9144159). Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. Monomer or homodimer (Probable). Interacts with cmd-1 in the presence of Ca(2+) (PubMed:17854888). Belongs to the protein kinase superfamily. Alpha-type protein kinase family.