Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids. ATP + H(+) + sulfate = adenosine 5'-phosphosulfate + diphosphate Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate: step 1/3. Homohexamer. Dimer of trimers. The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme. In the N-terminal section; belongs to the sulfate adenylyltransferase family. In the C-terminal section; belongs to the APS kinase family.