Functions as a multidrug and toxin extrusion transporter. Contributes to iron homeostasis during stress responses and senescence (PubMed:22150160). Could be involved in specifying the lateral organ initiation rate (PubMed:21257605). May act as a negative regulator of hypocotyl cell elongation in the light (PubMed:26160579). Highly expressed in shoot apices relative to leaves (PubMed:21257605). At vegetative stages, highly expressed at the stipules. At reproductive stages, most highly expressed in the mature pollen. Also expressed in the tips of sepals (PubMed:26160579). Induced by excessive iron, but repressed by iron deficiency. Induced by heat, darkness, osmotic stresses and acid abscisic (ABA). No visible phenotype. Plants overexpressing DTX48 in initiating leaves are short, produce leaves much faster than wild-type plants and show enhanced growth of axillary buds (PubMed:21257605). Overexpression of DTX48 alters shoot developmental programs leading to a loss of apical dominance phenotype (PubMed:26160579). Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.