Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity). CDP-choline + H2O = CMP + 2 H(+) + phosphocholine ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) CDP-glycerol + H2O = CMP + 2 H(+) + sn-glycerol 3-phosphate Monomer. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the ADPRibase-Mn family.