Its overexpression in smooth muscle cell lines increases their migratory ability and inhibits collagen type I expression. May act as a negative regulator of collagen matrix deposition. Expressed after injury in the carotid arteries (at protein level). Expressed in brain, lung, and after injury in fibroblasts of the adventitia and the neointima of the arteries. Strongly induced in carotid arteries after injury (balloon catheter injury model). By various growth factor (BMP4, TGFB1) in NIH 3T3 cell line. N-glycosylated.