Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms (By similarity). Promotes the repair of DNA double-strand breaks through the homologous recombination pathway (By similarity). Interacts with CBX1, CBX3, MAD2L2 and CHAMP1. Interacts with CBX5; POGZ competes with PXVXL motif-containing proteins such as INCENP and TRIM28 for interaction with CBX5 (By similarity). Interacts (via IBM motif) with PSIP1 (via IBD domain); phosphorylation increases its affinity for PSIP1 (By similarity). Interacts with HDGFL2 (By similarity). Recruited to trimethylated 'Lys-9' of histone H3 (H3K9me3). Phosphorylation increases its interaction with PSIP1.