NADH-dependent oxidoreductase which catalyzes the oxidation of all-trans-retinol to all-trans-retinal (PubMed:21995425). Plays a role in the regulation of cardiac and skeletal muscle metabolic functions (PubMed:21995425, PubMed:27806939, PubMed:29330505) (Probable). Maintains Ca(2+) intracellular homeostasis by repressing Ca(2+) release from the sarcoplasmic reticulum (SR) in myotubes, possibly through local alternations in NAD/NADH or retinol/retinal (PubMed:21995425). Also plays a role in Ca(2+) homeostasis by controlling Ca(2+) overload in the cytosol and the SR in myotubes (PubMed:27806939). Involved in glucose uptake into skeletal muscles and muscle performance by activating PI3K and mTORC2-mediated AKT1 phosphorylation signaling pathways, possibly through the action of its downstream catalytic product all-trans-retinoic acid (PubMed:29330505). all-trans-retinol + NAD(+) = all-trans-retinal + H(+) + NADH The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. In skeletal muscle, enriched in the longitudinal sarcoplasmic reticulum (PubMed:21995425). Expressed in skeletal muscle and cardiac muscle (PubMed:21995425, PubMed:22143674, PubMed:27806939). Also expressed in liver, kidney, adipocytes and skin (PubMed:21995425, PubMed:22143674). In skeletal muscle, expressed in differentiated myotubes but not in undifferentiated myoblasts. Induced by all-trans-retinoic acid (at transcriptional level). The N-terminus region encompasses a short hydrophobic sequence bound to the sarcoplasmic reticulum membrane, whereas the C-terminus catalytic domain faces the myoplasm. Belongs to the short-chain dehydrogenases/reductases (SDR) family.