Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR. Specifically expressed in brain, stomach and gut. Within the gut, expressed only in duodenum and jejunum. Expressed in the endoderm from the 14-somite stage. Aroound 9.5 dpc, present in the ventral prepancreatic and prehepatic regions (at protein level). At 14.5 dpc, expressed in brain, stomach and gut. Transcriptionally regulated by ONECUT1 in the developing endoderm. Belongs to the CUT homeobox family.