Core component of multiple cullin-RING-based CBC (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the CBC complex depends on the variable substrate recognition component (By similarity). May function in ubiquitin-mediated degradation of CKIs to target cki-1 for degradation. CBC(zif-1) may ensure germline precursor cell asymmetry by targeting germline proteins for destruction if expressed in non-germline cells (PubMed:12894212). As part of the CBC(fem-1) complex directs ubiquitination of tra-1 (PubMed:17609115). As part of the CBC(lrr-1) complex, required for the ubiquitination and dissasembly of the CMG helicase complex from chromatin at the end of DNA replication (PubMed:28368371). Positive cell-cycle regulator that is required at two distinct points in the cell cycle; the G1-to-S-phase transition and mitosis (PubMed:10587644). Also required for proper cytoskeletal movement and mitotic chromosome condensation (PubMed:10587644). Protein modification; protein ubiquitination. Component of multiple CBC (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes formed of cul-2, elb-1, elc-1, rbx-1 and a variable substrate recognition component (By similarity). Component of the CBC(fem-1) E3 ubiquitin-protein ligase complex with fem-1, fem-2 and fem-3 (PubMed:17609115). The CBC(fem-1) complex interacts with tra-1 and promotes tra-1 degradation (PubMed:17609115). Probable component of the CBC(lrr-1) E3 ubiquitin-protein ligase complex incuding cul-2, elb-1, elc-1, rbx-1 and lrr-1 (PubMed:28368371). The CBC(lrr-1) complex interacts with the DNA replisome complex at the end of S phase; the interaction promotes the release of components of the CMG helicase complex (a component of the replisome) from chromatin (PubMed:28368371). Probable component of an CBC(zif-1) E3 ubiquitin-protein ligase including cul-2, elc-1, rbx-1 and zif-1 (PubMed:12894212). Part of an E3 ubiquitin-protein ligase complex including cul-2, elc-1 and zyg-11 (PubMed:17304241). Interacts with Skp1-related protein skr-10 (PubMed:11864566). Nuclear in oocytes. In adults, highly expressed in meiotic cells and oocytes. In larvae, expressed in many proliferating cell types: P cells during the L1 stage; seam cells when they divide at every molt; vulval and somatic gonad cells in late L3 and L4 stages; and intestinal cells throughout larval development. Expressed both maternally and zygotically. Highest levels in embryos and lower levels in larvae and adults. Neddylated; which enhances the ubiquitination activity of CBC (Cul2-ElonginB-ElonginC) E3 ubiquitin-protein ligase complexes. RNAi-mediated knockdown prevents the release of sld-5 and psf-1 from chromatin prior to prophase in early embryos. Belongs to the cullin family.