Predominantly cytoplasmic. A small proportion is associated with secretory granules and membrane fractions. A small proportion is detected in the medium of cultured insuloma cells. Dexamethasone promotes the export into the culture medium. Highly expressed in pancreas, in particular in pancreatic islets and pancreatic beta-cells. Detected in prostate, adrenal gland, small intestine, stomach and thyroid (at protein level). Down-regulated in cultured insuloma cells after dexamethasone treatment.