Forms homotetramers with glycoprotein C at the surface of the virion (By similarity). Attaches the virion to host cell receptors including integrin ITGAV/ITGB3 (By similarity). This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity). Mediates the assembly and budding of infectious virus particles through its interaction with the nucleocapsid protein and the viral genome (By similarity). May dysregulate normal immune and endothelial cell responses through an ITAM motif (By similarity). Translocates to mitochondria, binds to host TUFM and recruits MAP1LC3B (By similarity). These interactions induce mitochondrial autophagy and therefore destruction of host MAVS leading to inhibition of type I interferon (IFN) responses (By similarity). Concomitant breakdown of glycoprotein N is apparently prevented by the nucleoprotein that may inhibit Gn-stimulated autophagosome-lysosome fusion (By similarity). Interacts with the viral genomic RNA (By similarity). Forms homotetramers with glycoprotein N at the surface of the virion. Attaches the virion to host cell receptors including integrin ITGAV/ITGB3. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Class II fusion protein that promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion. Homodimer (By similarity). Homotetramer; forms heterotetrameric Gn-Gc spikes in the pre-fusion conformation (By similarity). Interacts (via C-terminus) with the nucleoprotein (By similarity). Interacts with host TUFM; this interaction contributes to the virus-induced degradation of mitochondria by autophagy, which leads to degradation of host MAVS and inhibition of type I interferon (IFN) responses (By similarity). Interacts with host MAP1LC3B; this interaction contributes to the virus-induced degradation of mitochondria by autophagy, which leads to degradation of host MAVS and inhibition of type I interferon (IFN) responses (By similarity). Homodimer. Homotetramer; forms heterotetrameric Gn-Gc spikes in the pre-fusion conformation (By similarity). Homotrimer; forms homotrimer in the post-fusion conformation at acidic pH (By similarity). Interacts (via C-terminus) with the nucleoprotein (By similarity). Interaction between glycoprotein N and glycoprotein C is essential for proper targeting of glycoprotein N to the host Golgi complex, where virion budding occurs. Budding probably takes place at the host Golgi (Probable). Glycoprotein C cytoplasmic tail is important for efficient Golgi localization (By similarity). The YxxL motif at the C-terminus is indispensable for the interaction with MAP1LC3B and for the Gn-mediated induction of mitochondrial autophagy (By similarity). The cytoplasmic tail is involved in the inhibition of the host innate immune response (By similarity). The C-terminus of the cytoplasmic tail is involved in binding to the viral genome and the nucleocapsid (By similarity). Contains 2 contiguous zinc-fingers (By similarity). The C-terminus is necessary for proper localization in the Golgi (By similarity). The cytoplasmic tail is involved in binding to the nucleocapsid (By similarity). Envelope polyprotein precursor is quickly cleaved in vivo just after synthesis, presumably by host signal peptidase. Belongs to the hantavirus envelope glycoprotein family.