Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126, PubMed:26686862). Negatively regulates ADAM10-mediated cleavage of GP6 (By similarity). Promotes ADAM10-mediated cleavage of CDH5 (By similarity). Interacts with ADAM10; the interaction promotes ADAM10 maturation and cell surface expression. Belongs to the tetraspanin (TM4SF) family.