2 H(+) + H2O + urea = CO2 + 2 NH4(+) Nitrogen metabolism; urea degradation; CO(2) and NH(3) from urea (urease route): step 1/1. Probable heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. The trimeric urease interacts with an accessory complex composed of UreD, UreF and UreG, which is required for the assembly of the nickel containing metallocenter of UreC. The UreE protein may also play a direct role in nickel transfer to the urease apoprotein. By urea. Belongs to the urease beta subunit family.