Dual specificity mitochondrial citrate and methylcitrate synthase with similar catalytic efficiency with both acetyl-CoA and propionyl-CoA. acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+) Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. Leads to an accumulation of acetate and of isobutanol. Citrate synthase is found in nearly all cells capable of oxidative metabolism. Belongs to the citrate synthase family.