Member of the two-component regulatory system WalK/WalR that regulates genes involved in cell wall metabolism, virulence regulation, biofilm production, oxidative stress resistance and antibiotic resistance via direct or indirect regulation of autolysins (By similarity). Functions as a transcription regulator by direct binding to promoter regions (By similarity). Phosphorylated by WalK on Asp-53 (By similarity). Phosphorylated by PknB on Thr-101 (By similarity).