Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development. Interacts with FREM2. Localizes at the basement membrane zone of embryonic epidermis and hair follicles. The Calx-beta domain binds calcium with high affinity and undergo a major conformational shift upon binding. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Was termed QBRICK because it contains 12 repeats: 'Q' stands for queen and is taken from the queen being the 12th in a suit of playing card, and 'BRICK' stands for the repeating unit. Belongs to the FRAS1 family. Truncated N-terminus. Leiden Open Variation Database (LOVD)