Involved in the genetic cascade that governs left-right specification. Plays a role in the maintenance of a normal ciliary structure. Required for correct asymmetric expression of NODAL, LEFTY and PITX2. Interacts with PPP1R35; this interaction allows the mutual recruitment to the centriole. Colocalizes with the basal bodies at the primary cilium. The disease is caused by variants affecting the gene represented in this entry. May be due to an intron retention. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the rotatin family. Truncated N-terminus. Truncated N-terminus. Aberrant splicing. Truncated N-terminus.