Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation (By similarity). Involved in acrosomal reaction (Probable). May also play a role in smooth muscle cells migration (PubMed:15721306). Hydrolyzes glycerol monoesters of long-chain fatty acids. an acetyl ester + H2O = acetate + an aliphatic alcohol + H(+) a triacylglycerol + H2O = a diacylglycerol + a fatty acid + H(+) 2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-glycerol + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + glycerol + H(+) a butanoate ester + H2O = an aliphatic alcohol + butanoate + H(+) H2O + hexadecanoate ester = an aliphatic alcohol + H(+) + hexadecanoate Acylglycerol lipase activity is activated upon binding to progesterone. Absent from the sperm flagellum. Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart. Detected in embryos from 7 dpc to 17 dpc. Weakly expressed in heart at 9.5 dpc. Expression is detected in endothelial cells of the dorsal aorta at 10.5 dpc and disappear at 12.5 dpc. Expression in smooth muscle cells is first detected at 11.5 dpc. Strongly expressed in vitelline vessels at 12.5 dpc. Expressed in all smooth muscle cells at 16.5 dpc. Neointimal hyperplasia (PubMed:15721306). In lungs, decreased level of phosphatidylcholine in the bronchoalveolar lavage is observed (PubMed:19250629). Mice develop spontaneous gradual progression of emphysema (PubMed:19250629). Belongs to the AB hydrolase superfamily. AB hydrolase 4 family.