Major venom non-hemorrhagic metalloproteinase. Cleavage of 3-Asn-|-Gln-4, 10-His-|-Leu-11 and 14-Ala-|-Leu-15 in the insulin B chain, and the bond Z-Gly-Pro-|-Leu-Gly-Pro in a small molecule substrate of microbial collagenase. Binds 1 zinc ion per subunit. Monomer. Expressed by the venom gland. Belongs to the venom metalloproteinase (M12B) family. P-I subfamily.