NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide Binds 1 zinc ion per subunit. Belongs to the sirtuin family. Class II subfamily. Extended N-terminus.