Effector that enhances P.infestans colonization of Nicotiana benthamiana leaves (PubMed:24632534, PubMed:30329083). Induces a weak Cell death response in N. benthamiana. PexRD2-induced cell death is dependent on SGT1, suggesting that PexRD2 is recognized by the plant immune system (PubMed:19794118). Interacts with the kinase domain of the host MAPKKK epsilon, a positive regulator of cell death associated with plant immunity, and perturbs signaling pathways triggered by MAPKKK epsilon (PubMed:24632534, PubMed:28386988). Homodimer (PubMed:24632534, PubMed:21813644). Interacts with host MAPKKK epsilon (via its kinase domain) (PubMed:24632534). Expression is induced during host plant infection. The RxLR-dEER motif acts to carry the protein into the host cell cytoplasm through binding to cell surface phosphatidylinositol-3-phosphate. The WY domain contains 3 alpha-helices and is required for the interaction with the host MAPKKK epsilon. Belongs to the RxLR effector family.