Has antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (By similarity). Dimer. Interacts with RETN. ADP-ribosylation drastically reduces cytotoxic and antibacterial activities, and enhances IL8 production. Belongs to the alpha-defensin family.