May play a role during cell division. Distribution is highly dynamic during mitosis. Not detected during interphase, localized to cytoplasm during metaphase, to cleavage furrow during anaphase and telophase, and to midbody ring during cytokinesis. Widely expressed. Weakly detected in the dorsal forerunner cells at 80% epiboly to bud stages. At the 10-somite stage, strong expression is detected in the otic placodes, Kupffer's vesicles, and floor plate. Later, at 24 h post-fertilization, is mainly expressed in organs rich in motile cilia, including otic vesicles, pronephric ducts, and floor plates. At later stages, displays a ubiquitous expression pattern. Ankrd45 mutants are viable and show no apparent defects. However mutant larvae developed enlarged livers when induced with liver specific expression of Kras G12V, one of the common mutations of KRAS that leads to cancer in humans.