Member of the two-component regulatory system TodS/TodT involved in the regulation of toluene degradation. Phosphorylates TodT via a four-step phosphorelay in response to toluene (Probable). ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Homodimer. Binds as a dimer to a pseudopalindromic sequence. Contains a basic region leucine zipper dimerization motif at the N-terminus. Autophosphorylated. Activation requires a sequential transfer of a phosphate group from a His in the primary transmitter domain, to an Asp in the receiver domain and to a His in the secondary transmitter domain (By similarity). Mutants are unable to use toluene as the sole carbon source, are incapable of converting indole to indigo and do not have catechol dioxygenase activity.