Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of pathogen antigens. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates (By similarity). Predominantly expressed in liver and axillary lymph nodes. At very low levels also found in other tissues. In vitro, is a weak receptor for HIV-1 and SIV and poorly transmits HIV-1 to permissive T-cells relative to CD209.