Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Interacts with IL8. Interacts with GNAI2. Neutrophils. Belongs to the G-protein coupled receptor 1 family. Was originally thought to be the receptor for fMet-Leu-Phe (N-formyl peptide receptor).