Contributes to phagocytic removal of apoptotic cells in many tissues. Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Located in the acrosomal region of zona-pellucida bound sperm. Milk and spermatozoan. Also present in epididymis, kidney, heart, lymphatic gland and spleen but not esophagus, small intestine, muscle and liver. The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes. The two O-linked glycans consist of Gal, GlcNAc and Fuc, with probably Fuc as reducing terminal sugar.