May function in pre-mRNA splicing. Interacts with POLR2A. Ubiquitous. Highly expressed in fetal brain and liver, poorly expressed in salivary gland, heart, skin and ovary. Expressed in colorectal carcinomas and ovarian cancers. Overexpressed in colorectal carcinomas as compared to normal colonic mucosa. Up-regulated by estrogens, androgens and glucocorticoids. Belongs to the splicing factor SR family. Extended N-terminus.