Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two human complement regulators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellular matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also human complement control and complement evasion through binding to C4BPA, another human complement inhibitor, as well as through binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by human macrophages. Component of a multiprotein complex of 250 kDa composed of at least HYR1, MP65, and PRA1. Interacts with host Integrin alpha-M/beta-2 heterodimer. Binds also human factor H (CFH), CFHR1, plasminogen (PLG), complement C3, and C4BPA. Found primarily on the cell surface of filamentous forms and enriched at hyphal tips. Differentially expressed in response to changes in the pH with aximal expression at neutral pH and no expression detected below pH 6.0. Expression is controlled by RIM101. Expression is also increased during adhesion onto human epithelia. N- and O-glycosylated. The N- and 0-glycosidically linked carbohydrates represent 18 to 20 percent and 3 to 4 percent, respectively, of the molecular mass of PRA1. 0-linked sugar residues may be involved in the interaction with fibrinogen. Contributes highly to the carbohydrate component of the matrix. Treatment with tunicamycin impairs glycosylation. Impairs hypha formation. Protects the fungus against leukocyte killing in vitro and in vivo, impedes the innate immune response to the infection, and increases fungal virulence and organ invasion in vivo. Belongs to the ZPS1 family.