Component of the methylcitrate cycle that catalyzes the formation of pyruvate and succinate from 2-methylisocitrate during the metabolism of endogenous propionyl-CoA. (2S,3R)-3-hydroxybutane-1,2,3-tricarboxylate = pyruvate + succinate Inhibited in the presence of NADH and NADPH. When Mg(2+) is present, Cu(2+), Hg(2+) and Zn(2+) inhibit the enzyme activity in some extent. Optimum pH is 7.3-7.8. Optimum temperature is 40 degrees Celsius. Organic acid metabolism; propanoate degradation. Repressed by glucose. Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.