Plays a role in the cellular response to hydrogen peroxide and in the maintenance of mitochondrial integrity under conditions of cellular stress (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway (By similarity). Interacts (via VIM motif) with VCP. Translocates to the mitochondria upon exposure to hydrogen peroxide. Belongs to the ANKZF1/VMS1 family.