May be required for sorting endosomal resident proteins into late multivesicular endosomes by a mechanism involving microtubules. Interacts with CENPJ, LIP8 and ZNF521. Defects in LYST are the cause of Chediak-Higashi syndrome of cattle (CHS) CHS is an autosomal recessive bleeding disorder with light coat color which has been reported in a population of Japanese black cattle.