Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death. Associates with TRAF1, TRAF2, TRAF3 and TRAF5. Interacts with LINGO1. Highly expressed in prostate. Detected at lower levels in thymus, spleen, testis, uterus, small intestine, colon and peripheral blood leukocytes.