RNA-binding protein that acts as a mRNA splicing cofactor by promoting efficient splicing of transcripts that possess weak splice sites. Specifically promotes splicing of many cell-cycle and DNA-repair transcripts that possess weak splice sites, such as TUBG1, KATNB1, TUBGCP2, AURKB, PCNT, AKT1, RAD23A, and FANCG. Probably acts by facilitating the interaction between Serine/arginine-rich proteins such as SRSF2 and the RNA polymerase II. Also binds to DNA; binds to the consensus DNA sequence: 5'-GA[GT]AN[CG][AG]CC-3' (By similarity). Essential for correct RNA splicing of multiple genes critical for brain development, neuronal migration and metabolism, including TUBG1, FLNA, PNKP, WDR62, PSMD3, PCK2, PFKL, IDH2, and ACY1 (By similarity). May also regulate the ghrelin signaling in hypothalamic neuron by acting as a negative regulator of GHSR expression (PubMed:20876580). Interacts with SRSF2. Associates with the spliceosome. Interacts with USH1G. Colocalizes with the pre-mRNA splicing factor SRSF2. Widely expressed. Highly expressed in brain, heart, spleen, liver, skeletal muscle, kidney and testis. By leptin. Highly expressed in hypothalamus following leptin injection. Contains 8 types of repeats which are distributed in 3 regions. Contaminating sequence. Potential poly-A sequence.