Essential for thermotaxis by sensing environmental temperature. Receptor-activated non-selective cation channel involved in detection of sensations such as temperature. Involved in heat nociception by being activated by warm temperature of about 24-29 degrees Celsius. Homotetramer. Eliminates avoidance of elevated temperatures along a thermal gradient. Belongs to the transient receptor (TC 1.A.4) family. The power behind pain - Issue 82 of May 2007