Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. Tetramer of 2 light chains (p10 proteins) and 2 heavy chains (p36 proteins). In the lamina beneath the plasma membrane. A pair of annexin repeats may form one binding site for calcium and phospholipid. It may cross-link plasma membrane phospholipids with actin and the cytoskeleton and be involved with exocytosis. Belongs to the annexin family.