TIR-NB-LRR receptor-like protein involved in plant defense. Acts as a trigger of hypersensitive response (HR). Functions as guard of CAMTA3, a negative regulator of immunity, during pathogen infection. H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide Interacts with CAMTA3 and DSC2. The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Belongs to the disease resistance NB-LRR family.