A structure-specific endonuclease that binds and cleaves the four-way Holliday junctions in DNA created during repair and rearrangement by the ubiquitous process of homologous recombination. Introduces paired nicks in opposing strands; on immobile junction cleaves 2 bases 3' of the junction point, on mobile strands the cleavage site varies. Cleaves Y and loop-out structures with much lower efficiency. Binds 4-way junction DNA but not sequence-identical linear dsDNA. Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction). Homodimer. Belongs to the Holliday junction resolvase Hjc family. Hje subfamily.