Electroneutral sodium and chloride ion cotransporter. In kidney distal convoluted tubules, key mediator of sodium and chloride reabsorption (PubMed:8021284). Receptor for the pro-inflammatory cytokine IL18. Contributes to IL18-induced cytokine production, including IFNG, IL6, IL18 and CCL2, either independently of IL18R1, or as a complex with IL18R1 (By similarity). Activated by WNK3. Interacts with KLHL3 (By similarity). Interacts with IL18R1; this interaction is increased by IL18 treatment (By similarity). Expressed in kidney, predominantly in the outer cortex in short tubule segments. Ubiquitinated; ubiquitination is essential for regulation of endocytosis. Phosphorylated in response to IL18. Belongs to the SLC12A transporter family.