Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis (PubMed:15140022). Capable of killing E.coli but not S.aureus in vitro; digests outer membrane protein A (ompA) in E.coli and K.pneumoniae (PubMed:10947984). Hydrolysis of proteins, including elastin. Preferential cleavage: Val-|-Xaa > Ala-|-Xaa. Interacts with NOTCH2NL. Localized in phagolysosomes following ingestion of E.coli by neutrophils. Bone marrow cells. Neutrophil (PubMed:10947984). The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the peptidase S1 family. Elastase subfamily. Truncated N-terminus. ELA2 elastase, neutrophil expressed (ELANE) ELA2 mutation db Elastase entry