Second trifunctional enzyme acting on the beta-oxidation pathway for fatty acids, possessing hydratase-dehydrogenase-epimerase activities. Converts trans-2-enoyl-CoA via D-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH Lipid metabolism; fatty acid beta-oxidation. Monomer. Contains two SDR domains. Belongs to the short-chain dehydrogenases/reductases (SDR) family.