Involved in the planar cell polarity (PCP) pathway that is essential for the polarization of epithelial cells during morphogenetic processes, including gastrulation and neurulation (PubMed:26079437, PubMed:27658614). PCP is maintained by two molecular modules, the global and the core modules (PubMed:23140624). Proteins of the core module include the proteins Frizzled (Fz), Disheveled (Dsh), Van Gogh (Vang), Prickle (Pk), Flamingo (Fmi, Celsr) and Diego (Dgo) (PubMed:23140624). The core module proteins develop subcellular asymmetry, accumulating in two groups on opposite sides of epithelial cells (PubMed:23140624). Distinct proximal (Vang, Pk and Fmi) and distal (Fz, Dsh, Dgo and Fmi) complexes segregate to opposite sides of the cell, where they interact with the opposite complex in the neighboring cell at or near the adherents junctions (PubMed:23140624). Directional information to orient polarization with respect to the tissue axes is provided by the global module which involves Wnt proteins (PubMed:23140624). Involved in the organization of the basal body (PubMed:27062996). Involved in cilia growth and positioning (PubMed:27062996). Required for proper assembly, stability, and function of mitochondrial membrane ATP synthase (mitochondrial complex V) (By similarity). Interacts with vangl2 via its C-terminus (PubMed:27658614, PubMed:26079437). The vangl2-dependent membrane recruitment of prickle3 is a prerequisite for its polarization (PubMed:27062996). Interacts with wtip. Wtip is involved in the recruitment of prickle3 to the basal body (PubMed:27062996). Recruited by vangl2 to anterior cell borders. This polarity is controlled by wnt proteins (PubMed:27658614). Wtip is involved in the recruitment of prickle3 to the basal body (PubMed:27062996). Predominantly expressed in the epidermal ectoderm (PubMed:26079437). Belongs to the prickle / espinas / testin family.