Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1 (By similarity). The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily. Asn-331 is present instead of the conserved Asp which is expected to be an active site residue.