Acts as a lysosomal receptor for glucosylceramidase (GBA) targeting. (Microbial infection) Acts as a receptor for enterovirus 71. Interacts with GBA. (Microbial infection) Interacts with enterovirus 71 capsid proteins VP1 and VP2. The disease is caused by variants affecting the gene represented in this entry. Genetic variants in SCARB2 can act as modifier of the phenotypic expression and severity of Gaucher disease. Belongs to the CD36 family.