ATP + H2O = ADP + H(+) + phosphate Expressed in heart, placenta, liver, skeletal muscles, and pancreas. Lower levels of expression are also detected in brain, lung and kidney. Weakly expressed in the adult brain. Expression in fetal brain is higher than in adult brain, with levels similar to several other fetal tissues including spleen and skeletal muscle. In adult brain expressed at low levels in all tissues examined, including the temporal lobe and putamen (PubMed:15925480). Highly expressed in the respiratory and integumentary systems (PubMed:29505581). Decreased by half in the SLI patient lymphoblasts. A chromosomal aberration involving ATP13A4 is found in 2 patients with specific language impairment (SLI) disorders. Paracentric inversion inv(3)(q25;q29). The inversion produces a disruption of the protein. Dubious isoform lacking mature mRNA evidence. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. Wrong choice of CDS.