Involved in the biosynthesis of the antimalarial endoperoxide artemisinin (PubMed:16458889, PubMed:16612385, PubMed:20351109, PubMed:27488942). Catalyzes three consecutive oxidations of amorpha-4,11-diene to produce artemisinic acid, with artemisinic alcohol and artemisinic aldehyde as intermediates products, but is unable to oxidize germacrene A (PubMed:16458889, PubMed:16612385, PubMed:20351109, PubMed:23246612). No activity with limonene, alpha-pinene, beta-pinene, pinocarveol, (-)-alloisolongifolene, caryophyllene, (-)-alpha-gurjunene, (+)-gamma-gurjunene, (+)-ledene, (+)-beta-selinene and (+)-valencene as substrates (PubMed:16458889, PubMed:16612385, PubMed:20351109). (+)-amorpha-4,11-diene + 3 O2 + 3 reduced [NADPH--hemoprotein reductase] = (+)-artemisinate + 4 H(+) + 4 H2O + 3 oxidized [NADPH--hemoprotein reductase] Sesquiterpene biosynthesis. Highly expressed both in apical and sub-apical cells of glandular secretory trichomes (PubMed:22195571, PubMed:19664791). Detected in flower buds, leaves and roots (PubMed:22986332). Also present in non-glandular trichome cells (PubMed:30851440). Strongly induced by gibberellic acid (GA(3)) leading to an increased artemisinin yield (Ref.19). Accumulates in the presence of trans-cinnamic acid (PubMed:22986332). Artemisinin and derivatives (e.g. artesunate), are antimalarial drugs due to their endoperoxidase properties; they also display multiple pharmacological actions against inflammation,viral infections, and cell and tumor proliferation (PubMed:32514287, PubMed:32405226). Artesunate may be a promising treatment for COVID-19 mediated by the severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2) because of its anti-inflammatory activity, NF-kappaB (nuclear factor kappa B)-coronavirus effect and chloroquine-like endocytosis inhibition mechanism (PubMed:32514287, PubMed:32405226). Yeast (S.cerevisiae) has been engineered to produce artemisinic-acid, a precursor of the antimalarial artemisinin compound, by expressing AMS1/ADS, CYP71AV1, ADH1 and ALDH1 in conjunction with CYB5 and CPR1. Reduced production of artemisinic acid (AA) but increased accumulation of artemisinic alcohol (AAOH) and artemisinic aldehyde (AAA), and production of (DHAA) probably due to a lower catalytic activity. Belongs to the cytochrome P450 family. Truncated N-terminus. Truncated N-terminus.