(S)-malate + NADP(+) = CO2 + NADPH + pyruvate H(+) + oxaloacetate = CO2 + pyruvate Divalent metal cations. Prefers magnesium or manganese. Homotetramer. Expressed in the fruiting body. Expressed at late stage of development (20 to 24 hours). By cAMP and the MADS-box protein srfA. Belongs to the malic enzymes family.