Involved in teeth and skeletal development. Has an essential role in the biosynthesis and trafficking of glycosaminoglycans and glycoproteins to produce a proper functioning extracellular matrix. Required for extracellular matrix mineralization (PubMed:30082715). Also involved in the regulation of cellular calcium homeostasis (By similarity). Does not show transport activity towards bile acids or steroid sulfates (including taurocholate, cholate, chenodeoxycholate, estrone-3-sulfate, dehydroepiandrosterone sulfate (DHEAS) and pregnenolone sulfate). Expressed in heart, brain, colon, lung, liver, adrenal gland, stomach and ovary. Also expressed weakly in small intestine. Expressed in skeletal tissues (PubMed:30082715). Embryos at gestational age 12.5 dpc show the weakest SLC10A7 expression, mainly in the heart trabeculae of the developing heart and the cartilage of the vertebrae. From 14.5 dpc onwards, expression becomes more ubiquitous, with the strongest level observed at 16.5 dpc and postnatal day P0. At 14.5 dpc, it is strongly expressed in cartilaginous structures in the mandible, in the epithelial compartment of cap stage teeth, in the digits, in the spine and in the lung. At 16.5 dpc, transcripts are mostly localized in the inner dental epithelium and in the epithelial loop of bell stage teeth. At 18.5 dpc expression is observed in the inner dental epithelium of incisors, and in ameloblasts and odontoblasts of molars. At postnatal day P0 there is strong expression in the papillary layer of the oral mucous membrane underneath the palate, as well as in the ameloblast layer of emerging teeth. At postnatal day P10, it is localized to the growth plate of several long bones, such as the forefoot digits, the hindfoot tarsals and the humerus, and expression is more intense in the chondrocytes of the hypertrophic zone. Knockout mice present with skeletal dysplasia including growth retardation at birth and at 8 weeks, alteration of long-bone morphology, craniofacial anomalies and advanced tarsal maturation at birth, associated with enamel defects. The proportion of heparan sulfate (HS) in cartilage of knockout mice is significantly reduced compared with wild-type animals. SLC10A7 deficiency has no impact on skeletal muscle heparan sulfate levels. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family. Truncated C-terminus.