Plays a role in the oxidative stress response and the maintenance of longevity by regulating the interaction between GTPase rho-1 and oxidase bli-3 (PubMed:28085666). In turn, this serves to modulate bli-3 activity and the control of reactive oxygen species production (PubMed:28085666). May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton (By similarity). Interacts with rho-1. Expressed in neuronal and non-neuronal cells in the head and tail, pharyngeal cells, spermatheca, distal tip cells, anchor cell and the intestine. Expressed from embryogenesis to adulthood. 7-38% increase in lifespan compared to wild-type animals. Increased nuclear accumulation of the transcription factor skn-1. Increased resistance to oxidative stress as indicated by an increase in the expression of genes related to the oxidative stress response and activation of the p38 MAPK pathway. Increased reactive oxygen species production. Knockout with bli-3 RNAi rescues the enhanced longevity and increased reactive oxygen species production defects. Knockout with rho-1 RNAi suppresses reactive oxygen species induction and longevity in the memo-1 mutant. Double RNAi mediated knockdown with bli-3 suppresses the nuclear localization of skn-1 in the memo-1 single mutant. Double RNAi-mediated knockdown with rho-1 eliminates the resistance to oxidative stress in the memo-1 single mutant. Belongs to the MEMO1 family.