Amine transporter (PubMed:1722321). Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals (By similarity). Regulator of light-dependent retinal hyaloid vessel regression, downstream of OPN5 signaling (By similarity). Homooligomer; disulfide-linked (By similarity). Interacts with PRKCABP and TGFB1I1 (By similarity). Interacts (via N-terminus) with SYNGR3 (via N-terminus) (By similarity). Interacts with SLC18A2 (By similarity). Interacts with TOR1A (ATP-bound); TOR1A regulates SLC6A3 subcellular location (By similarity). Interacts with alpha-synuclein/SNCA (By similarity). Interacts with SEPTIN4 (By similarity). Localizes to neurite tips in neuronal cells (By similarity). Colocalizes with SEPTIN4 at axon terminals, especially at the varicosities (By similarity). Expressed in the neurons of the substantia nigra of the brain. This protein is the target of psychomotor stimulants such as amphetamines or cocaine. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A3 subfamily.