Controls the expression level of the Mmps2-MmpL2, MmpS4-MmpL4, and MmpS5-MmpL5 transport systems. Also controls its own expression. Acts by binding directly to the promoter regions. Homodimer. Negatively autoregulated. Mutations or insertions/deletions that inactivate MmpR5, or decrease its activity, lead to increased levels of MmpL5 and MmpS5, and to non-target based resistance to azoles, clofazimine and bedaquiline.