Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B (PubMed:26990309). Interacts with FYB1 (By similarity). Colocalizes with FYB1 at cell-cell contacts in podocytes. Highly expressed in brain. Belongs to the TMEM47 family.