Receptor which may mediate L-selectin-dependent lymphocyte rollings. Binds SELL in a calcium dependent manner. Binds lymphocyte. Exclusively localized on capillary endothelium. Transcytoses across the cytoplasm in the capillary endothelium. Expressed in monocyte cell lines. Expressed in certain types of endothelial and myeloid lineage cells. Expressed in mesenteric lymph nodes (LNs), spleen, thymus, lung, heart and kidney. Expressed in high endothelial venules (HEVs) in peripheral and mesenteric LNs (at protein level). Highly expressed in heart. Slightly expressed in spleen and thymus. Isoform 5 is expressed preferentially in heart. Isoform 1 is expressed predominantly in kidney and liver. Ig-like V-type domain mediates binding to lymphocyte. O-glycosylated with sialylated oligosaccharides. Belongs to the CD300 family.