Plays a key role in glycolysis and gluconeogenesis. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Homotetramer. A number of isoforms are produced. According to EST sequences. Highly expressed in rosettes leaves. By glucose and sucrose (PubMed:22561114). Induced by drought stress (PubMed:22561114). Can be trimethylated at Lys-394 by LSMT-L. The methylation level has no influence on the ologomerization state or on the kinetic properties of the enzyme. Phosphorylated on tyrosine residues in response to abscisic acid (ABA) in germinating seeds. Reduced growth rate. Unability to accumulate starch in leaves during daylight. Belongs to the class I fructose-bisphosphate aldolase family.