Affects the ASIC3 channel (ACCN3) and produces analgesic effects. It produces a reversible inhibition effect on both the transient and the sustained current of human ASIC3 channels expressed in X.laevis oocytes. It completely blocks the transient component (IC(50)=10 uM) and partially (48%) inhibits the amplitude of the sustained component (IC(50)=1.44 uM). Using in vivo tests in mice, it reverses inflammatory and acid-induced pain. Does not affect the ASIC3 channel. Does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg. Does not affect the ASIC3 channel. Does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg. Pi-AnmTX Ugr 9a-1, AnmTX Ugr 9a-2 and AnmTX Ugr 9a-3 have a structural fold called the boundless beta-hairpin since its beta-hairpin is not stabilized by disulfide bonds. Average mass. Average mass. Average mass. Shows neither agonistic nor antagonistic activity on ASIC1a/ASIC1, ASIC1b/ASIC1 and ASIC2a/ASIC2 at concentrations up to 50 uM as well as on the hKv1.3/KCNA3 channel at concentrations up to 1 uM. It does not cause lethality or paralysis of noble crayfish (A.astacus) at a dose of 1 mg/kg. Belongs to the sea anemone structural class 9a family.