Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (Probable). In endogenous ribosomes interacts with P-site tRNA and 23S rRNA (PubMed:18988853, PubMed:20421507). In the presence of truncated mRNA in the 70S ribosome, ArfA and RF2 interact such that the GGQ peptide hydrolysis motif of RF2 rises into the peptidyl-transferase center and releases the ribosome (By similarity). Recruited to stalled E.coli 70S ribosomes by E.coli ArfA, but cannot be functionally accomodated in the peptidyl-transferase center (PubMed:27934701, PubMed:28077875). Note T.thermophilus probably does not encode arfA (Ref.1). Interacts with the ribosome (PubMed:16377566, PubMed:17272297, PubMed:18988853, PubMed:20421507). Interacts with ribosomal protein L11 (PubMed:18988853). Recruited to stalled E.coli ribosomes by E.coli ArfA (PubMed:27934701, PubMed:28077875). Belongs to the prokaryotic/mitochondrial release factor family.