Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the coupling of the nucleus and centrosome and dynein/dynactin-mediated interactions of microtubule tips with the cell cortex. Interacts with dynein and mtaA/CP224 in the cortical attachment of microtubules. Interacts with rac1A. Localizes to microtubules and to the centrosome throughout the entire cell cycle. Is part of the centrosomal corona. Dimerization mediated by the LisH domain may be required to activate dynein. Belongs to the WD repeat LIS1/nudF family.