Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Responsible for approximately one-third of 4-hydroxy-2-nonenal conjugation (Ref.1, PubMed:16164425, PubMed:16300482). May play a role in the detoxification of reactive oxygen species produced during pathogenic bacterial infection (PubMed:22216003). glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Homodimer. Expressed in cells at the mouth and adjacent to the pharyngeal bulbs of the head and also in the tail. Increase in susceptibility to 4-hydroxy-2-nonenal, paraquat and heat shock and a reduced lifespan. Belongs to the GST superfamily. Pi family.