Potent and specific inhibitor of CaM-kinase II (CAMK2) (PubMed:11182241). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (By similarity). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (PubMed:31327268). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (By similarity). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268). Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (PubMed:11182241). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+) (PubMed:11182241). Brain specific (PubMed:11182241). Highly expressed in frontal cortex, hippocampus, olfactory bulb, caudate-putamen and cerebellum (at protein level) (PubMed:11182241). Knockout in a spontaneously hypertensive rat model results in decreased blood pressure and vascular reactivity to N-omega-Nitro-L-arginine methyl ester hydrochloride (PubMed:31327268). Increased renal and serum endothelial nitric oxide synthase and serum nitrate levels (PubMed:31327268). Reduced fasting plasma glucose concentrations and a 23% decrease in visceral and brown adipose tissue relative mass, resulting from a decrease in adipocyte number (PubMed:31327268). Belongs to the CAMK2N family.