Induces a potassium channel when expressed in Xenopus oocytes. Selectively present in the distal parts of the nephron (medullary and papillary collecting ducts and end portions of cortical collecting tubule) and in the epithelial cells of the distal colon. No expression is found in renal proximal tubule, loop of henle and distal tubule, proximal colon, small intestine, lung, choroid plexus, salivary glands, or brain. By corticosteroids. Belongs to the FXYD family.