Disrupts bidirectional nucleocytoplasmic transport by interacting with host RAE1-NUP98 complex (PubMed:33849972). Disrupts cell nuclear import complex formation also by tethering karyopherin alpha 2 and karyopherin beta 1 to the membrane (PubMed:17596301). Retention of import factors at the ER/Golgi membrane leads to a loss of transport into the nucleus (PubMed:17596301). Thereby prevents STAT1 nuclear translocation in response to interferon signaling, thus blocking the expression of interferon stimulated genes (ISGs) that display multiple antiviral activities (PubMed:17596301). May interact with nsp8 (PubMed:17532020). Interacts with protein ORF9b (PubMed:22820404). Interacts with host RAE1 in NUP98-RAE1 complex (PubMed:35096974); the interaction disrupts the host nuclear import (PubMed:33849972). Interacts with host KPNA2 (PubMed:17596301). Localizes to virus-induced vesicular structures called double membrane vesicles. Belongs to the coronaviruses accessory protein 6 family.