Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Binds MYD88 via their respective TIR domains (By similarity). Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800). Belongs to the Toll-like receptor family. There is some confusion regarding the nomenclature of this gene. In the literature, Tlr11 is frequently referred to as Tlr12 and vice-versa. In some plant proteins and in human SARM1, the TIR domain has NAD(+) hydrolase (NADase) activity (By similarity). However, despite the presence of the catalytic Asp residue, the isolated TIR domain of human TLR4 lacks NADase activity (By similarity). Based on this, it is unlikely that Toll-like receptors have NADase activity.