Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin selectively inhibits alpha-3-beta-2/CHRNA3-CHRNB2 (IC(50)=3.51 uM) and alpha-6/alpha-3-beta-2-beta-3 (CHRNA6/CHRNA3-CHRNB2-CHRNB3) (IC(50)=0.94 uM) nAChRs. Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/7 pattern. The 6 amino-acid N-terminal tail displays a well-defined structure and plays a role in stabilizing the peptide. Does not show inhibition on rat alpha-7/CHRNA7, alpha-4-beta-2/CHRNA4-CHRNB2, alpha-4-beta-4/CHRNA4-CHRNB4, alpha-3-beta-4/CHRNA3-CHRNB4, alpha-2-beta-2/CHRNA2-CHRNB2, alpha-2-beta-4/CHRNA2-CHRNB4, and alpha-1-beta-1-gamma-delta/CHRNA1-CHRNB1-CHRNG-CHRND acetylcholine receptors, as well as on human alpha-9-alpha-10/CHRNA9-CHRNA10 subtype. Belongs to the conotoxin A superfamily.