Core component of multiple SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes. Involved in ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Interacts with SKIP17 and FBW2/SKIP18. Neddylated; which enhances the ubiquitination activity of E3 ubiquitin-protein ligase complexes. Belongs to the cullin family.