Oxidoreductase having both tropinone reductase I and II activities. Involved in the tropane alkaloids calystegines and cochlearine biosynthesis. Can use tropinone and nortropinone as substrates and produces both tropine and pseudotropine. Able to oxidize pseudotropine in the reverse reaction. NADP(+) + tropine = H(+) + NADPH + tropinone NADP(+) + pseudotropine = H(+) + NADPH + tropinone Optimum pH is 8.0. The pH has no influence on the tropine to pseudotropine product ratio. The hydroxyphenyl ring arrangement of Tyr-209 determines the tropinone orientation and the formation of either tropine or pseudotropine. Belongs to the short-chain dehydrogenases/reductases (SDR) family. SDR65C subfamily.