Scaffold protein involved in different aspects of polarized cell differentiation regulating epithelial and neuronal morphogenesis and T-cell polarization (PubMed:12499390, PubMed:18716323, PubMed:19041750, PubMed:18329370). Via its interaction with CRTAM, required for the late phase polarization of a subset of CD4+ T-cells, which in turn regulates TCR-mediated proliferation and IFNG and IL22 production (PubMed:18329370). Most probably functions in the establishment of apico-basal cell polarity (PubMed:19041750). May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium (PubMed:19041750). May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling (PubMed:18716323). May play a role in exocytosis and in the targeting of synaptic vesicles to synapses (PubMed:19458197). Functions as an activator of Rac GTPase activity. Interacts with UBE3A (By similarity). Interacts with PAK1 and PAK2 (PubMed:18716323). Interacts (via PDZ domains) with VANGL2 (PubMed:16687519). Interacts (via PDZ domains) with LPP and TRIP6; the interaction is direct (By similarity). Interacts (via PDZ domains) with TJP2 (By similarity). Interacts (via PDZ domains) with APC; may mediate APC targeting to adherens junctions of epithelial cells (PubMed:16611247). Interacts (via PDZ domains) with TSHR; regulates TSHR trafficking and function (By similarity). Interacts with ARHGEF7 and GIT1; interacts directly with ARHGEF7 (PubMed:15182672). Interacts with CTNNB1 (PubMed:16611247, PubMed:19458197). Interacts with MAPK12 (PubMed:15878399). Interacts (via PDZ domains 1 and 3) with MCC (By similarity). Interacts with DLG5 (By similarity). Interacts with STK4/MST1 and LATS1 in the presence of DLG5 (By similarity). Interacts (via PDZ domain 3) with CRTAM (via PDZ-binding motif); the interaction promotes CRTAM and SCRIB polarization in a subset of CD4+ T-cells (PubMed:18329370). Targeting to cell-cell junctions which is CDH1-dependent is required for the pro-apoptotic activity (By similarity). In a subset of CD4+ T-cells, colocalizes with CRTAM at the immunological synapse during the late phase of T-cell activation (PubMed:18329370). Expressed in CD4+ T-cells (at protein level) (PubMed:18329370). Found in a wide range of tissues including liver, kidney and spleen (PubMed:15806148). Also expressed in the brain (at protein level) (PubMed:15182672, PubMed:15806148). First detected at 7.5 dpc in the neuroepithelium at the time of initial neural tube closure. Also expressed in cranial mesenchyme, branchial arches, somitic mesoderm and lateral mesoderm. At later stages it is expressed in the eyelid epithelium, submandibular glands, whisker and hair follicles, sympathetic glanglia, inner ear, thymus, testis, kidney, esophagus, lung, stomach, trigeminal and dorsal root glanglia. Ubiquitinated; targeted for UBE3A-dependent multiubiquitination and degraded. Palmitoylated. Could be depalmitoylated by LYPLA1 and/or LYPLA2. Palmitoylation of SCRIB by ZDHHC7 is required for its localization to cell-cell junctions, function in the establishement of epithelial cell polarity and the regulation of downstream signaling pathways important for epithelial cell differentiation. The circletail (Crc) mice exhibit craniorachischisis, a severe form of neural tube defect. This is due to a single base insertion in the Scrib gene creating a frameshift which leads to synthesis of a truncated protein. Belongs to the LAP (LRR and PDZ) protein family. Extended N-terminus.