Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine (PubMed:10572016, PubMed:17442255, PubMed:17302437, PubMed:28581482). Utilizes a ping-pong kinetic mechanism in which the succinyl group of succinyl-CoA is initially transferred to the enzyme to form a succinyl-enzyme intermediate before subsequent transfer to homoserine to form the final product, O-succinylhomoserine (PubMed:10572016, PubMed:17442255, PubMed:17302437). Cannot use acetyl-CoA (PubMed:10572016). L-homoserine + succinyl-CoA = CoA + O-succinyl-L-homoserine Inhibited by iodoacetamide in a pH-dependent manner. kcat is 24 sec(-1) with succinyl-CoA as substrate. kcat is 24 sec(-1) with L-homoserine as substrate. kcat is 5.23 sec(-1) with CoA as substrate. kcat is 5.23 sec(-1) with O-succinylhomoserine as substrate. Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; O-succinyl-L-homoserine from L-homoserine: step 1/1. Homodimer. Contains two transcription starting points, P1 and P2, which are 74 bp apart. P1 is under negative control by methionine, whereas P2 is independent of the intracellular methionine concentration. Belongs to the MetA family.