Proton-activated chloride channel that mediates import of chloride ion in response to extracellular acidic pH (PubMed:31023925). Involved in acidosis-induced cell death by mediating chloride influx and subsequent cell swelling (PubMed:31023925). Mice are viable and appear mostly normal (PubMed:31023925). Cortical neurons completely lack proton-activated chloride channel activity (PubMed:31023925). Neurons are partially but significantly protected from delayed cell death induced by 1-hour acid treatment (PubMed:31023925). Belongs to the proton-activated chloride channel family.