Antimicrobial peptide with activity against both Gram-positive and Gram-negative bacteria (PubMed:9225251). Antibacterial activities have been tested against Bacillus cereus (MIC=12.5 ug/ml), Escherichia coli (MIC=50 ug/ml), Leuconostoc mesenteroides (MIC=25 ug/ml), Micrococcus luteus (MIC=1.5 ug/ml), Pastewella haemolytica (MIC=0.8 ug/ml), Staphylococcus aureus (MIC<l00 ug/ml), Streptococcus faecalis (MIC<150 ug/ml) and Streptococcus uberis (MIC=50 ug/ml) (PubMed:9225251). Strongly inhibits the formation of NO by neuronal nitric oxide synthase (nNOS) at micromolar concentrations (PubMed:11784303). Acts by a non-competitive mechanism, probably by binding to calcium/calmodulin and as a consequence blocking calmodulin attachment to nNOS (PubMed:11784303). Expressed by the granular skin glands. Forms an amphipathic alpha-helix over residues 47-60 while the C-terminal eight residues are more flexible and less structured. The flexible region may be responsible for the lack of antimicrobial activity. Belongs to the frog skin active peptide (FSAP) family. Frenatin subfamily.