Transcription factor that regulates metabolic homeostasis in response to oxidative stress (By similarity). Binds to the consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (By similarity). Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). May be involved in regulating cellular homeostasis in the eye (PubMed:17993506). Shuttles between the cytoplasm and nucleus. Expressed in the developing eye. In 48h embryos, enriched within the periocular mesenchyme (POM), in the branchial arch region and in the developing pancreas.