Inhibits host immune defense by binding to host TNF and various chemokines (By similarity). Binds host CC chemokines (beta chemokines) and CXC chemokines (alpha chemokines) (By similarity). Homodimer. Interacts with host TNF, LTA, CCL28, CCL25, CXCL12, CXCL13 and CXCl14. The N-terminal region is similar to host TNF receptor 2/TNFRSF1B and binds host TNF. The C-terminal region is called smallpox virus-encoded chemokine receptor (SECRET), and binds host cytokines. Belongs to the poxviridae chemokine-binding protein family.