Required to maintain the full capacity of the mycobacterium to respond to oxidative stress via the degradation of oxidation-induced damaged nucleotides. Hydrolyzes all canonical (d)NTPs, as well as mutagenic dUTP and 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate (8-oxo-dGTP). Also involved in the transcriptional activation of RelA in response to oxidative stress. ATP + H2O = AMP + diphosphate + H(+) Optimum pH is 9.6. Optimum temperature is 37 degrees Celsius. The activity is abolished at 70 degrees Celsius. Homotetramer. By oxidative stress. Belongs to the nucleoside triphosphate pyrophosphohydrolase family.