Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase. Enterostatin has a biological activity as a satiety signal. Forms a 1:1 stoichiometric complex with pancreatic lipase. Expressed by the pancreas. Readily detectable during gestation, reaches adult levels by 17-20 days gestation, rises markedly at 7 days of age but falls to adult levels by 14 days and remains at that level throughout the suckling-weanling period. Expression levels increase upon lipid ingestion. Belongs to the colipase family.