May act as a tumor suppressor. Expressed in head mesenchyme, somitic mesoderm and notochord at stages 8 and 9. Expressed in the presumptive otic vesicles at stage 9. Expressed in the somites, the entire notochord and the otic epithelium at stage 9. In the developing inner ear, expressed in the entire elongating endolymphatic duct and sac as well as the medial otic epithelium between stages 15 and 23. Expressed in the otic vesicle, somitic mesoderm and notochord at stage 13. Through the cranial region, expressed at the surface ectoderm, head mesenchyme, optic cups, roof plate of the forebrain and notochord at stage 13. In the paraxial mesoderm, expressed in the cranial region of the presomitic mesoderm at stage 13. In the somitic mesoderm, expressed in the somite before de-epithelialization and subsequently in the dermomyotome at stage 13. In the caudal region, expressed in the notochord, paraxial mesoderm and endoderm. Expressed in the optic cup, otic vesicle and somitic mesoderm stage 19. Expressed in the mesenchymal cells surrounding the optic cup and the surface ectoderm overlying the lens vesicle at stage 19. Expressed in the mesonephric ducts and tubules at stage 19. In the somatopleure and limb buds, expressed in the surface ectoderm and mesenchymal cells immediately beneath the surface ectoderm at stage 19. In the somitic mesoderm, expressed in the dermomyotome and lateral sclerotome at stage 19. Expressed in the branchial arches and maxillary process at stages 22 and 23. In the somitic mesoderm, expressed in the myotome at stage 24. In the limb buds, expressed in the anterior region of the fore- and hindlimb buds at stage 24. In the developing inner ear, expressed in the medial side of the utricle, the saccule, and the emerging cochlea at stage 27. Belongs to the DAN family.