Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. Might function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism (By similarity). Interacts with TBP and the transcription factor IID (TFIID) complex, NR5A2, NR1H3 and PPARG. Interaction with TBP is regulated by phosphorylation. Binds NR5A1, ATF1 and FOS via their conserved basic region (By similarity). Interacts with JUN. Binding to calmodulin is regulated by calcium and phosphorylation of the IQ motif. Also nuclear upon binding to NR5A1 and treatment of cells with TPA or forskolin (By similarity). Localized mainly in soma and dendritic processes of neurons. Expressed in cardiomyocytes, cortical and hippocampal neurons. Expressed in newborn and adult heart and brain tissues. Expression is not evident in prenatal days. Up-regulated upon cardiomyocytes hypertrophy. The IQ motif, which is involved in calmodulin binding, overlaps with the binding domain for nuclear receptors and transcription factors. Its phosphorylation probably allows a switch between the two activities of the protein. Phosphorylated.