Pleiotropic ABC efflux transporter that confers resistance to structurally and functionally unrelated compounds including caspofungin or azoles such as fluconazole, itraconazole, posaconazole, voriconazole, and isavuconazole (PubMed:11257032, PubMed:12244114, PubMed:12557277, PubMed:15105134, PubMed:15388433, PubMed:16803598, PubMed:17581937, PubMed:20038613, PubMed:24273749, PubMed:24838041, PubMed:26482310, PubMed:27486188, PubMed:29371812). Does not play a role in the azole resistance in mature biofilms (PubMed:18651314). Azole exposure induced expression via regulation by the transcription factor PDR1 that stimulates gene expression via binding to elements called pleiotropic drug response elements (PDREs) (PubMed:15388433, PubMed:19148266, PubMed:25199772, PubMed:29464833). Expression is up-regulated in azole-resistant isolates and in presence of fluconazole (PubMed:9661006, PubMed:16803598, PubMed:17581937, PubMed:18782778, PubMed:19196495, PubMed:20038613, PubMed:27486188, PubMed:29371812). Loss of mitochondrial functions leads to increased expression (PubMed:21321146). Expression is temporary increased during the intermediate phase of biofilm development (PubMed:18651314). Expression is down-regulated by the transcription factor STB5 (PubMed:23229483). Expression is negatively regulated by the transcription factor JJJ1 via inactivation of the PDR1 transcriptional pathway (PubMed:29507891). Expression is also decreased by amphotericin B in voriconazole-resistant strains (PubMed:21282443). Phosphorylated by PKA. Dephosphorylated on glucose depletion and independently rephosphorylated during glucose exposure or under stress. Increases the susceptibility to rhodamine 6G, cycloheximide and chloramphenicol, and also increases rhodamine 6G accumulation (PubMed:12557277). Suppresses the development of high-frequency azole resistance (HFAR) in a medium containing fluconazole (PubMed:11257032). Impairs the blockage of the efflux of fluconazole by milbemycin A4 oxime when CDR1 is also deleted (PubMed:24838041). Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.