Hydrolyzes carbapenems, penicillins, cephalosporins and aztreonam with varying efficiency. a beta-lactam + H2O = a substituted beta-amino acid Not inhibited by EDTA, inhibited by clavulanic acid and tazobactam. Initially two different KPC beta-lactamases were identified from two different bacteria (KPC-1 and KPC-2); they were later shown to be identical. Belongs to the class-A beta-lactamase family.