High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. (Microbial infection) Acts as a receptor for human cytomegalovirus pentamer-dependent entry in epithelial and endothelial cells. Heterodimer with NRP1. Binds PLXNB1. (Microbial infection) Interacts with human cytomegalovirus proteins gL, UL128, UL130 and UL131A. The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. Belongs to the neuropilin family.