Pore-forming protein which might play a role in host defense. Exists as an antiparallel dimer in solution. Can also assemble into an octameric pore-like structure spanning the cell membrane. Oligomerization may be triggered by binding of the jacalin-type lectin domain to high-mannose cell-surface proteoglycans, and also requires a low pH environment. In vitro, shows high binding affinity for S.cerevisiae mannan and human HIV virus glycoprotein gp120. Homodimer in soluble form. Forms an octameric pore-like structure in the membrane. Up-regulated in the presence of organophosphate pesticides and zinc. The jacalin-type lectin domain has strong affinity for high-mannose glycans with terminal non-reducing ends of Man(alpha-1,2)Man or Man(alpha-1,3)Man.