May play a role in apoptosis. Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed. Involved in dental enamel formation (PubMed:30506946). Interacts with RELL1, RELL2, OXSR1, PLSCR1 and STK39. Expressed in the teeth. Expressed by secretory stage ameloblasts and by odontoblasts at postnatal day 5. It is not detected in maturation stage ameloblasts and only residual expression is observed in odontoblasts by postnatal day 12. Phosphorylated in vitro by OXSR1. Phosphorylated by STK39. Belongs to the RELT family.