Cytochrome P450 involved in the biosynthesis of the benzylisoquinoline alkaloid noscapine (PubMed:24316226, PubMed:27378283, PubMed:29610307). Converts (S)-tetrahydrocolumbamine to (S)-canadine (PubMed:24316226, PubMed:27378283). (S)-tetrahydrocolumbamine + O2 + reduced [NADPH--hemoprotein reductase] = (S)-canadine + H(+) + 2 H2O + oxidized [NADPH--hemoprotein reductase] Alkaloid biosynthesis. Belongs to the cytochrome P450 family.