Antagonizes host cell apoptosis by interacting with host ferritin heavy chain. The ORF4 protein physically binds host FHC, resulting in the reduction of FHC protein levels in host cells. Reduction of FHC concentration further inhibits the accumulation of reactive oxygen in host cells, leading to reduced apoptosis. Interacts with host FTH1 (PubMed:26333394, PubMed:27030984). May interact with host ANT3 (PubMed:29491154). Other experiments suggest that it may enhance apoptosis instead of antagonizing it.