May play a role in axon growth and regeneration. May be involved in epidermal cell adhesion and epidermal structure and function. Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS (By similarity). In neuronal cells, associated with GPI-anchored cell-adhesion molecules. Brain, retina and skin. Expressed during embryogenesis, postnatal stages and in adult. By optic nerve injury. ZDHHC5-catalyzed palmitoylation may be required for the formation of higher-order complexes and for neurite outgrowth in cultured neural stem cells. Belongs to the band 7/mec-2 family. Flotillin subfamily.