Transports sulfoconjugated steroid hormones from the extracellular compartment into the cytosol in a sodium-dependent manner without hydrolysis (PubMed:15020217). Steroid sulfate hormones are commonly considered to be biologically inactive metabolites, that may be activated by steroid sulfatases into free steroids (By similarity). May play an important role by delivering sulfoconjugated steroids to specific target cells in reproductive organs (By similarity). May play a role transporting the estriol precursor 16alpha-hydroxydehydroepiandrosterone 3-sulfate (16a-OH-DHEAS) at the fetal blood vessel endothelium (By similarity). Can also transport other sulfoconjugated molecules such as taurolithocholic acid-3-sulfate and sulfoconjugated pyrenes (By similarity). estrone 3-sulfate(out) + 2 Na(+)(out) = estrone 3-sulfate(in) + 2 Na(+)(in) 17beta-estradiol 3-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 3-sulfate(in) + 2 Na(+)(in) dehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = dehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) androst-5-ene-diol 3-sulfate(out) + 2 Na(+)(out) = androst-5-ene-diol 3-sulfate(in) + 2 Na(+)(in) 2 Na(+)(out) + pregnenolone sulfate(out) = 2 Na(+)(in) + pregnenolone sulfate(in) 2 Na(+)(out) + taurolithocholate 3-sulfate(out) = 2 Na(+)(in) + taurolithocholate 3-sulfate(in) androsterone 3alpha-sulfate(out) + 2 Na(+)(out) = androsterone 3alpha-sulfate(in) + 2 Na(+)(in) 5alpha-dihydrotestosterone sulfate(out) + 2 Na(+)(out) = 5alpha-dihydrotestosterone sulfate(in) + 2 Na(+)(in) 17beta-estradiol 17-sulfate(out) + 2 Na(+)(out) = 17beta-estradiol 17-sulfate(in) + 2 Na(+)(in) 17alpha-hydroxypregnenolone 3-sulfate(out) + 2 Na(+)(out) = 17alpha-hydroxypregnenolone 3-sulfate(in) + 2 Na(+)(in) epiandrosterone 3-sulfate(out) + 2 Na(+)(out) = epiandrosterone 3-sulfate(in) + 2 Na(+)(in) epitestosterone 17-sulfate(out) + 2 Na(+)(out) = epitestosterone 17-sulfate(in) + 2 Na(+)(in) 2 Na(+)(out) + testosterone 17-sulfate(out) = 2 Na(+)(in) + testosterone 17-sulfate(in) 16alpha-hydroxydehydroepiandrosterone 3-sulfate(out) + 2 Na(+)(out) = 16alpha-hydroxydehydroepiandrosterone 3-sulfate(in) + 2 Na(+)(in) Highly expressed in heart, lung, spleen and adrenal gland. Moderately expressed in skeletal muscle, testis and small intestine. Glycosylated. In humans, 3-beta-sulfooxy-androst-5-en-17-one (DHEAS) is the most abundant circulating steroid sulfate in the human body, it is mainly synthesized from adrenal glands and gonads, whereas rats and mice have low circulating concentrations of DHEAS in the periphery as they can only produce DHEAS in their gonads. Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.