Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. Required for correct retinal pattern formation and may function in cell fate determination through its interactions with the EGFR and Notch signaling pathways. Required for associative odor learning and short-term memory. Involved in development of the neuromuscular junction and the mushroom body. Interacts with RII subunit of PKA and components of the EGFR-mediated and Notch-mediated signaling pathways. Found in the cortical region of perikarya with no expression in neuropil regions. Located at or near the Golgi network in perikarya of the dorsal medial cluster neurons. In early embryos, ubiquitous expression with elevated levels in ventral furrow and flanking mesectodermal cells, neuroblasts and mesoderm. Late embryos show reduced expression in epidermis and skeletal muscle and elevated in nervous system, gut endothelium, tracheal system and salivary gland. Larvae show expression in imaginal disks and many neural cells. Developing eye imaginal disk shows expression throughout the disk and in the region of the morphogenetic furrow. Ubiquitous expression in adults with higher levels in head region. Expressed in larval neurons but not in larval glia. All stages of development. RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Mutants are viable and fertile but display a rough eye surface phenotype, impaired short-term memory, aberrant associative odor learning, aberrant neuromuscular junction morphology with increased numbers of synaptic boutons, and defective axonal morphology of the Kenyon cells, the neurons of the mushroom body. Belongs to the WD repeat neurobeachin family. Intron retention. In addition to the intron retained at the N-terminus, there are other discrepancies towards the C-terminus. Truncated N-terminus. Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform. Intron retention. In addition, there are retained or missing exons which cannot be reconciled with any described isoform.