Tick salivary platelet aggregation inhibitor that plays an important part in the anti-hemostatic strategy of ticks (PubMed:8120028). Inhibits fibrinogen interaction with platelets (PubMed:8120028). Acts by binding (in a divalent metal ion dependent manner) to the glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) on the platelet surface and inhibits aggregation induced by ADP (IC(50)=99-104 nM), thrombin, collagen (IC(50)=64 nM) platelet-activating factor and collagen (PubMed:8120028, PubMed:9434779, PubMed:33537548). Interacts to unstimulated platelets (Kd=42.5 nM) and to ADP-stimulated platelets (Kd=39.4 nM) (PubMed:8120028). In contrast to many disintegrins which only interact with the beta-3 subunit, interacts with the two subunits (alpha-IIb and beta-3) (PubMed:8120028, PubMed:9434779). Under flow conditions, reduces and delays platelet adhesion, aggregation, and fibrin formation (PubMed:33537548). Expressed in salivary glands.