Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. a beta-lactam + H2O = a substituted beta-amino acid Binds 2 Zn(2+) ions per subunit. It can also bind Cd(2+) and Co(2+) to a lesser extent (PubMed:9416622). Competitively inhibited by 4-morpholineethanesulfonic acid (MES), SB236050 and biphenyl tetrazoles (BPTs) (PubMed:9578564, PubMed:9545432, PubMed:12019104). Also inhibited by chelating agents such as EDTA and 1,10-phenanthroline (PubMed:9712862). CcrA is not susceptible to inactivation by the beta-lactamase-blocking agents clavulanic acid or tazobactam (PubMed:2121094, PubMed:2110145). kcat is 225.7 sec(-1) for lactamase activity with nitrocefin as substrate (with zinc ions at pH 7 and 25 degrees Celsius). kcat is 107.6 sec(-1) for lactamase activity with nitrocefin as substrate (with cobalt ions at pH 7 and 25 degrees Celsius). Monomer. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.