May mediate the cholesterol and gangliosides transport from the plasma membrane to intracellular vesicles in an ATP hydrolysis dependent manner, thus playing a role in their internalization by endocytic retrograde transport and may also participate in the endocytosis of synaptic vesicle in cortical neurons. ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate Significantly expressed in the bone marrow, trachea, testis, thyroid and lung as well as in skin fibroblasts. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Belongs to the ABC transporter superfamily. Truncated N-terminus. Truncated C-terminus. Database for mutations in ABC proteins