May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. May regulate ITCH and NEDD4 E3 ligase activity and degradation (PubMed:26854353). (Microbial infection) Acts as a receptor for Venezuelan equine encephalitis virus. Interacts with APP precursor C-terminus. Interacts directly with ITCH; this interaction promotes ITCH auto-ubiquitination leading to its degradation (PubMed:26854353). Interacts directly with NEDD4; this interaction promotes NEDD4 auto-ubiquitination (PubMed:26854353). Interacts directly with NEDD4L (PubMed:26854353). (Microbial infection) Interacts with Venezuelan equine encephalitis virus/VEEV spike proteins E1 and E2. Expressed at high levels in brain, lung, skeletal muscle, and pancreas. Expressed at moderate levels in heart, placenta, and kidney but not detected in the liver. Belongs to the LDLR family.