Palmitoylates Dlish which is required for the apical cell cortex localization, total cellular level and full activity of dachs. hexadecanoyl-CoA + L-cysteinyl-[protein] = CoA + S-hexadecanoyl-L-cysteinyl-[protein] Interacts with Dlish (via N-terminus including SH3 domain 1); this leads to palmitoylation of Dlish by app. Interacts with ft; this is likely to interfere with the interaction between app and Dlish, reducing the ability of app to palmitoylate Dlish and tether it to the apical cell cortex. Detected in embryo, imaginal disks and pupal wings (at protein level) (PubMed:18804377). Enriched in the somatic musculature and gut throughout embryonic development (PubMed:18719403). The DHHC domain is required for palmitoyltransferase activity. Semi-lethal in homozygotes and heterozygotes with adult escapers showing abdominal planar cell polarity defects and also extensive wing planar cell polarity defects, both proximally and in a distal region between the third and fourth longitudinal veins. Greatly reduced accumulation of dachs at the apical cell cortex. Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.