Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). ATP + H2O = ADP + H(+) + phosphate Forms homohexameric rings (Probable). Can form a dodecamer with ruvbl2 made of two stacked hexameric rings (By similarity). Is a component of the RNA polymerase II holoenzyme complex (By similarity). Component of the chromatin-remodeling Ino80 complex. Component of some MLL1/MLL complex (By similarity). Expression decreases until onset of zygotic transcription before increasing again at later stages. Is expressed in neural crest cells, in particular in a subpopulation that give raise to the adrenal medulla. Belongs to the RuvB family.