Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of the plasma membrane (PubMed:24904167, PubMed:26799398, PubMed:30018401, PubMed:24898253). Major PS-flippase in immune cell subsets (PubMed:30018401). In erythrocyte plasma membrane, it is required to maintain PS in the inner leaflet preventing its exposure on the surface. This asymmetric distribution is critical for the survival of erythrocytes in circulation since externalized PS is a phagocytic signal for erythrocyte clearance by splenic macrophages (PubMed:24898253). Required for B cell differentiation past the pro-B cell stage (PubMed:21423173). Seems to mediate PS flipping in pro-B cells (PubMed:21423172, PubMed:26799398). May be involved in the transport of cholestatic bile acids (PubMed:21518881). ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2. a 1,2-diacyl-sn-glycero-3-phospho-L-serine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phospho-L-serine(in) + ADP + H(+) + phosphate a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(out) + ATP + H2O = a 1,2-diacyl-sn-glycero-3-phosphoethanolamine(in) + ADP + H(+) + phosphate Component of a P4-ATPase flippase complex which consists of a catalytic alpha subunit ATP11C and an accessory beta subunit TMEM30A. Efficient exit from the endoplasmic reticulum requires the presence of TMEM30A. Internalized via clathrin-dependent endocytosis in response to ca(2+) signaling induced by G-protein coupled serotonin and histamine receptors, HTR2A and HRH1 respectively. Widely expressed. Expressed in retina, brain, liver and testes (at protein level) (PubMed:30018401). Expressed in lung, bone marrow, lymph nodes, prostate, ovary and uterus (PubMed:24904167). Expressed in fetus (PubMed:24904167). The di-leucine motif is required for sorting to clathrin-coated endosomes upon ca(2+)-dependent PRKCA activation. Proteolytically cleaved by CASP3, CASP6 and CASP7. Phosphorylated at Ser-1113 likely by PRKCA; this creates a functional di-leucine motif that is sufficient for endocytosis. Mice defective in Atp11c show defective B lymphopoiesis, specifically in mature bone marrow, pronounced stomatocytosis associated with anemia, hyperbilirubinemia linked to mild cholestasis and hepatocellular carcinoma. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.