Involved in the biosynthesis of labdane-type diterpenoid including sclareol, a diterpene-diol that is used as fragrance and flavoring, and has anticancer effects (able to kill leukemic and colon cancer cells by apoptosis) (Probable). Sclareol can also be used as synthesis precursor of ambergris substitution fragance products such as ambrox (Probable). Terpene synthase that produces 8-hydroxycopalyl diphosphate from geranylgeranyl diphosphate (GGPP) (PubMed:23113661, PubMed:22834731). (2E,6E,10E)-geranylgeranyl diphosphate + H2O = 8-hydroxycopalyl diphosphate Secondary metabolite biosynthesis; terpenoid biosynthesis. The Asp-Xaa-Asp-Asp (DXDD) motif is important for the catalytic activity, presumably through binding to Mg(2+). Escherichia coli expressing SsLPS and SsSCS from Salvia sclarea and CrtE from Pantoea agglomerans can produce sclareol in high-cell-density fermentation conditions, thus being an alternative, sustainable, and cost-efficient route to sclareol and other diterpene analogs. Yeast (S.cerevisiae) engineered to express S.cerevisiae GGPPS and Salvia sclarea LPS and SCS is an efficient way to produce sclareol in a scalable and potentially industrial way. Belongs to the terpene synthase family.