This enzyme participates in both the breakdown and synthesis of glucose. alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate Binds 1 Mg(2+) ion per subunit. Monomer. Phosphorylation at Thr-467 by PAK1 significantly enhances enzymatic activity. Belongs to the phosphohexose mutase family. There is a known reversal of the Pgm1 and Pgm2 nomenclature applied to mouse versus other vertebrates. The official name of this gene in mouse is Pgm2 but it is the ortholog of other vertebrate PGM1 genes.