May act as an RNA-binding protein. Sensitive to various stresses including heat, sodium dodecyl sulfate and calcineurin inhibitor tacrolimus (PubMed:27611567). Resistant to tunicamycin-induced ER stress (PubMed:27611567). Simultaneous disruption of CRZ1 enhances thermosensitivity and decreases virulence in a mouse intranasal inhalation model for pulmonary infection (PubMed:27611567).