May play a role in uric acid excretion. Additional isoforms seem to exist. Isoform 4 is expressed in placenta, lung, kidney and pancreas. Thr-62 is associated with increased risk for uric acid nephrolithiasis. Disease susceptibility is associated with variants affecting the gene represented in this entry. Isoform 4 (talanin) of ZNF365 does not exist in rodents. In primates, a canonical intron-exon structure exist, with several stop codons preventing talanin production in old world and new world monkeys. It seems therefore that isoform 4 transcript emerged during primate evolution from a noncoding genomic sequence.