Receptor for the netrin NTN4 that promotes neuronal cell survival (PubMed:21216843). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration (By similarity). Plays a role in the regulation of neuronal cell migration in the developing brain via its interaction with FLRT2 (PubMed:21673655). Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:21673655). May play a role in apoptosis in response to DNA damage. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (PubMed:26235030). Interacts (via extracellular domain) with FLRT2 and FLRT3 (via extracellular domain); the interaction is direct (PubMed:19492039, PubMed:21673655, PubMed:25374360, PubMed:26235030). Has higher affinity for FLRT2 (PubMed:25374360). Identified in a complex with FLRT3 and ADGRL3; does not interact with ADGRL3 by itself (PubMed:26235030). Detected in multipolar cells in the brain subventricular zone (at protein level) (PubMed:18547816). Detected in embryonic brain neocortex, especially in the subventricular zone (PubMed:21673655). Detected in multipolar cells in the brain subventricular zone (PubMed:18547816). Detected in brain neocortex from young pups, especially in the somatosensory cortex (PubMed:21216843). Expressed in developing limb and mammary gland (PubMed:12351186). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis (By similarity). No visible phenotype. Mice are viable, appear healthy, and do not display any obvious behavorial defects. Cortical neurons from mutant mice display impaired axon growth cone collapse in response to Flrt2 and a tendency towards accelerated radial migration in the developing brain. Belongs to the unc-5 family.