Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. Binds calmodulin via its IQ domains. Associates with the cytoskeleton. The D-box (destruction box) mediate the interaction with APC proteins, and may act as a recognition signal for degradation via the ubiquitin-proteasome pathway.