Binds to phospholipid vesicles in a calcium-dependent manner in vitro (PubMed:16331990, PubMed:18441010). Prefers phosphatidyl-serine containing membranes. May have a role in the membrane cytoskeleton scaffolding or exocytotic processes (PubMed:16331990). May be involved in oxidative stress response (Probable). Monomer (PubMed:12142457, PubMed:12787021). Trimer. Oligomerization is calcium-independent. Disassembly of the oligomers seems to be required for calcium-binding (PubMed:12787021). A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family.