Probable core component of cullin-based SCF-like E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit (By similarity). Required at several stages during development. CulA and fbxA regulate multicellular development by targeting regA for degradation via a pathway that requires erkB function, leading to an increase in cAMP and PKA activity. Protein modification; protein ubiquitination. Part of a complex that includes culA, fbxA and regA. Formation of this complex is dependent on the MAP kinase erkB. Neddylated; which enhances the ubiquitination activity of SCF. Cells are defective in inducing cell-type-specific gene expression and exhibit defects during aggregation, including reduced chemotaxis. Belongs to the cullin family.