Member of the two-component regulatory system GtrS/GltR involved in the regulation of glucose metabolism and transport, as well as regulation of the exotoxin A gene expression (PubMed:24920832). GltR controls the transcription of genes involved in glucose metabolism (glk and edd/gap-1) and transport (oprB) as well as the expression of toxA that encodes exotoxin A, the primary virulence factor (PubMed:8830708, PubMed:24920832). Acts as a repressor that is released from its target operators upon phosphorylation (PubMed:24920832). Contributes to modulation of the type III secretion system (T3SS) in response to host cells via the regulation of the OprB transport system. Phosphorylation of GltR induces its dissociation from DNA leading to transcriptional activation. Phosphorylated by GtrS. Disruption of the gene causes loss of glucose transport activity (PubMed:8830708). Inactivation results in elevated ingestion and reduced cytotoxicity of eukaryotic cells during P.aeruginosa infection (PubMed:22262100).