Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is a kinase that is involved in down-regulation of the host innate response induced by invasive bacteria. Prevents or at least delays host phospho-NF-kappa-B inhibitor alpha (NFKBIA) degradation. Does not phosphorylate E2 enzymes. Binds various host ubiquitinated E2 ubiquitin-conjugating enzymes, including UBE2D2 (UBCH5B). Secreted via Mxi-Spa type III secretion system (TTSS), and delivered into the host cell. Autophosphorylated. Mutant induces a stronger inflammatory reaction upon infection. Belongs to the protein kinase superfamily.