Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:7477349). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (By similarity). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (PubMed:21540451). Interacts with CRHR1 and CRHR2 (via their N-terminal extracellular domain). Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.