Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene (By similarity). Interacts with the cytoplasmic part of UNC5A, UNC5B and UNC5C (PubMed:10399920). Interacts with DSCAM (By similarity). Interacts with PTK2/FAK1 (By similarity). Interacts with MYO10 (By similarity). Interacts with MAPK1 (PubMed:21070949). Interacts with NTN1 (PubMed:8861902). Interacts with CBLN4; this interaction can be competed by NTN1 (By similarity). Interacts with SIAH1 and SIAH2 (By similarity). Detected in embryonic spinal cord, predominantly in axons of commissural neurons (at protein level). Detected in embryonic spinal cord. Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation. Belongs to the immunoglobulin superfamily. DCC family.