Primate-specific protein involved in cortical expansion and folding in the developing neocortex. May drive neural progenitor proliferation through nuclear translocation of IQGAP1, which in turn promotes G1/S cell cycle transitions. Interacts with IQGAP1; this interaction promotes phosphorylation and nuclear translocation of IQGAP1. Mainly expressed in the outer subventricular zone (OSVZ) of the fetal brains. When expressed in embryonic mouse neocortex, induces intermediate progenitor cells and outer radial glia expansion, cortical thickening and induces gyrification (PubMed:29033352). Belongs to the TMEM14 family.