Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy (PubMed:22343712, PubMed:26436652). Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD (By similarity). Interacts with LMNA. Interacts with ISL1 (via N-terminal domain); the interaction represses ISL1 transactivator activity. Expressed in cardiomyoctes. Expression is highly reduced in hypertrophic cardiomyocytes. Extended N-terminus.