May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes. Induction seems to be correlated with apoptotic cell death in hepatoma cells. Interacts with YBX1 (By similarity). Interacts with TTN/titin. Mainly expressed in activated vascular endothelial cells. To a lower extent, also expressed in hepatoma cells. By TNF, IL1A/interleukin-1 alpha and parthenolide.