Catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. Has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin H2 Lipid metabolism; prostaglandin biosynthesis. Monomer. P110/11E abundance is markedly elevated in promastigotes relative to amastigotes. Belongs to the aldo/keto reductase family.