Required for renal function. Homooligomer (PubMed:19324013). Central component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3 (PubMed:23793029). ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme (PubMed:23793029). Interacts (via SAM domain) with BICC1 (via KH domains) in an RNA-dependent manner (PubMed:19324013). Interacts (via SAM domain) with ANKS3 (via SAM domain) (PubMed:25671767, PubMed:26327442, PubMed:26188091). Localizes to the proximal region of the primary cilium in the presence of INVS. Widely expressed with moderate level in brain, skeletal muscle and testis. Expressed in renal tubules. The ankyrin repeats are necessary and sufficient for NEK8-binding. Hydroxylated at Asn-129, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding. Defects in Anks6 are the cause of polycystic kidney disease (cy). Heterozygous cy rats are characterized by progressive formation and enlargement of cysts in kidneys. Wrong choice of frame.