Interferon-stimulated protein that plays a role in innate immunity. Strongly inhibits ebolavirus transcription and replication. Forms a complex with viral RNA-bound nucleocapsid NP and thereby prevents the transport of NP to the cell surface. Interacts with CEP164. (Microbial infection) Interacts with ebolavirus protein NP; this interaction sequesters NP in the cytoplasm. Up to threefold after interferon treatment. Phosphorylated at Ser-209 by TTBK2. It is uncertain whether Met-1 or Met-18 is the initiator.