Involved in poly(A)+ RNA transport (By similarity). Involved in nephrogenesis (PubMed:30427554). Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus. Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores. Widely expressed in the embryo and in adult tissues. Higher expression is observed in the brain, testes, ovary, skin, and kidney. Morpholino knockdown of the protein results in anomalies of the head, brain and kidney. Morphant embryos show decreased head sizes, reduced axonal numbers in the forebrain and midbrain, and disorganization in the hindbrain. As for the renal tissues, morphants show underdeveloped glomeruli with hypoplastic capillary vessels, and abnormal podocytes. Belongs to the nucleoporin Nup133 family.