Hydrolase that specifically degrades the potent antimicrobial compound 2,4-diacetylphloroglucinol (DAPG) to equimolar amounts of mildly toxic monoacetylphloroglucinol (MAPG) and acetate. Does not degrade other compounds with structures similar to DAPG, such as MAPG and triacetylphloroglucinol, suggesting strict substrate specificity (PubMed:16391073). Degradation of DAPG to MAPG may provide an additional means of fine-tuning levels of this antibiotic or may help avoid accumulation of a metabolite that at high levels may become toxic to the producing bacterium (PubMed:16391073). 2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate Activity is strongly reduced by pyoluteorin, an antifungal compound produced by the bacterium. kcat is 33 sec(-1). Activity is slightly enhanced at pH 6.6 and pH 6.0. Retains only 10% of its maximal activity at pH 7.6 and is inactive at pH 8.0. Expression is induced by the GacS/GacA two-component system and repressed by the pathway-specific regulators PhlF and PhlH. Expression is not influenced by the substrate DAPG or the degradation product MAPG. The phlA-phlG double mutant cannot degrade DAPG. Belongs to the DAPG/phloretin hydrolase family.