Cytokine which is the ligand for CD27. The CD70-CD27 pathway plays an important role in the generation and maintenance of T cell immunity, in particular during antiviral responses. Upon CD27 binding, induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Homotrimer. The disease is caused by variants affecting the gene represented in this entry. Belongs to the tumor necrosis factor family.