May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling. Plays a role in intracellular transport of vesicular stomatitis virus nucleocapsids from the endosome to the cytoplasm. Homooligomer. Interacts with EGFR (By similarity). Detected in placenta, lung, liver,heart and pancreas. The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family.