Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (By similarity). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (By similarity). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (By similarity). Interacts with FBXW7; promotes FBXW7 degradation (By similarity). May interact with RAF1 (By similarity). Interacts with KIF22; recruits KIF22 to mitotic spindle microtubules (By similarity). Interacts (via C-terminus) with DYNLL1 (By similarity). Interacts with HMMR (By similarity). Interacts (via N-terminus) with CSNK1A1/CK1a; in mitotic cells (By similarity). Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. Phosphorylated during mitosis. Belongs to the FAM83 family.