Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect. acetyl-CoA + H2O + oxaloacetate = citrate + CoA + H(+) Carbohydrate metabolism; tricarboxylic acid cycle; isocitrate from oxaloacetate: step 1/2. Homodimer. By decoyinine and nutrient depletion. Citrate synthase is found in nearly all cells capable of oxidative metabolism. Belongs to the citrate synthase family.