Probable large-conductance Ca(2+)-activated chloride channel. May play a role in Ca(2+) signal transduction. Expressed in excitable tissues. Expressed in the brain, heart, skeletal muscle, colon, spleen, kidney and peripheral blood leukocytes. N-glycosylated. The current is completely inhibited by the addition of an anion permeability inhibitor. Addition of a Ca(2+) ionophore induces an outward-rectified current in mock-transfected cells, but it introduced an overt linear current in TTYH3-transfected cells. Belongs to the tweety family.