May be involved in pre-mRNA splicing (By similarity). May confer protection against toxicity induced by heavy metals such as arsenite, possibly by negatively regulating the expression of phase II detoxification genes such as gcs-1 in intestinal cells (PubMed:25204677). May be part of a spliceosome complex. RNAi-mediated knockdown results in increased sensitivity to the heavy metal arsenite. Belongs to the SYF2 family.