Active on adenosine(5')triphospho(5')adenosine (Ap3A), ADP-ribose, NADH, adenosine(5')diphospho(5')adenosine (Ap2A). ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) Mg(2+). Other divalent cations can also be used. Homodimer. Belongs to the Nudix hydrolase family.