Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can use both NADH and ADP-ribose as substrates, but not 8-oxo-dGTP, cyclic ADP-ribose, GDP-manose, UDP-glucose, ATP, or GTP. Exerts negative control of EDS1 signaling. ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide Not inhibited by fluoride. Optimum pH is 8.5. Optimum temperature is 50 degrees Celsius. Homodimer. Interacts with RACK1A, GG1 and GG2. Localized at the plasma membrane when in complex with GG2, but present in the cytoplasm when associated with GG1. Detected in the cytoplasm and nucleus when interacting with RACK1A. A number of isoforms are produced. According to EST sequences. Expressed in stems, leaves, roots, flowers and siliques. Rapid and transient induction by biotic and abiotic stresses. Not induced by H(2)O(2). Growth retardation, constitutive pathogen resistance phenotype and increased levels of reactive oxygen species and NADH. Belongs to the Nudix hydrolase family.