This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of phospholipids (Probable). Forms a heteromeric phospholipid translocase (PLT) DNF3-CRF1, implicated in the translocation of phospholipids from the outer to the inner leaflet of membrane bilayers. Shares an essential function for cell growth with PLTs DRS2-CDC50 and DNF1/2-LEM3. May be involved in transport from early endosomes to the trans-Golgi network (TGN) (Probable). ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2. Interacts with YNR048W/CRF1; interaction is required for proper expression and endoplasmic reticulum (ER) export of either partner. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.