Precursors of the cornified envelope of the stratum. Skin-specific. Expression was readily detected in adult trunk skin, adult arm skin, fetal skin, penal skin, vulva, esophagus and tongue. Not expressed in the cervix, rectum, lung, colon, or placenta. By calcium and UVB. Belongs to the LCE cluster present on 1q21. Belongs to the LCE family.