ATP + H2O = ADP + H(+) + phosphate Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP. Exhibits granular localization in the nucleus, as well as in the cytoplasm. Expressed in fibroblasts (at protein level). The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. The disease is caused by variants affecting the gene represented in this entry. Belongs to the DEAD box helicase family. DDX59 subfamily. Contaminating sequence. Potential poly-A sequence starting in position 433.