NAD-dependent histone deacetylase, which could function in telomeric silencing, cell cycle progression and chromosome stability. H2O + N(6)-acetyl-L-lysyl-[protein] + NAD(+) = 2''-O-acetyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide Binds 1 zinc ion per subunit. Belongs to the sirtuin family. Class I subfamily. The predicted gene AN3647 has been split into 3 genes: AN10433, AN10449 and AN10450.