Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth. GTP = 3',5'-cyclic GMP + diphosphate Widely expressed. Expressed in the columnar proliferating and prehypertrophic chondrocyte layers of the tibia. Phosphorylated. Phosphorylation of the protein kinase-like domain is required for full activation by CNP. Glycosylated. Mice mainly display dwarfism associated with impairment of endochondral ossification, reduced growth of longitudinal vertebra and limb-bone. Self-clasping and priapism that could be due to neuronal disorder are detected. The development of the female reproductive organ is affected. Binds ligand, but no cyclase activation. Fail to bind the ligand. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.