Has strong antifungal activity against C.albicans MDM8, C.krusei IOC 4559 (MIC=2.5-5 uM), C.glabrata IOC 45658 (MIC=2.5-5 uM), C.albicans IOC 45588 (MIC=2.5-5 uM), C.parapsilosis IOC 456416 (MIC=2.5-5 uM), C.tropicalis IOC 45608 (MIC=2.5-5 uM), C.guilliermondii IOC 455716 (MIC=2.5-5 uM) and A.niger (MIC=5-10 uM). Lacks antifungal activity against B.bassiana. Has no antibacterial effect against Gram-positive bacteria M.luteus, S.epidermidis, S.aureus or against Gram-negative bacteria E.coli and P.aeruginosa. Has no hemolytic activity against human erythrocytes. Probable ion channel inhibitor (By similarity). Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Belongs to the neurotoxin 12 (Hwtx-2) family. 03 (juruin) subfamily.