Prevents infected cell apoptosis induced by the host immune system. Acts by down-regulating a number of cell surface receptors in the tumor necrosis factor (TNF) receptor superfamily, namely FAS, TNFRSF10A/TRAIL receptor 1, and TNFRSF10B/TRAIL receptor 2. Down-regulation of these death receptors protects adenovirus-infected cells from apoptosis induced by the death receptor ligands Fas ligand and TRAIL. RID complex also down-regulates certain tyrosine kinase cell surface receptors, especially the epidermal growth factor receptor (EGFR). RID-mediated Fas and EGFR down-regulation occurs via endocytosis of the receptors into endosomes followed by transport to and degradation within lysosomes. Homodimer with only one chain cleaved by signal peptidase. Interacts with E3 RID-beta and E3 CR1-alpha. The signal peptide is only cleaved partially by host signal peptidase. This results in two forms of the protein, one uncleaved with two transmembrane regions, and one cleaved with one transmembrane region (PubMed:1531278). Belongs to the adenoviridae E3-RID-alpha family.