Promotes up-regulation of actin stress fiber formation. Interacts with vinculin by the first two SH3 domains and the proline rich region of vinculin. Binds to SOS (guanine nucleotide exchange factor of RAS and RAC), through its third SH3 domain. The formation of this complex is down-regulated by phosphorylation of SOS. Interacts with SAFB2, INPPL1/SHIP2 and SRCIN1 (By similarity). Interacts with DLG5 through its third SH3 domain. Interacts with SOCS7 and MAPK1/ERK2. Interacts with FASLG (By similarity). Localized at focal adhesion sites, cell-cell junctions and cell-extracellular matrix junctions. Phosphorylated at Ser-594 by MAPK1/ERK2 during cell spreading.