Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity). Plays a role in the maintenance of long-term retrieval-induced memory in response to contextual fear (PubMed:28642476). Modulates blood pressure and vascular reactivity via regulation of CAMK2 activity in addition to regulation of left ventricular mass (By similarity). Mediates the NLRP3 inflammasome in cardiomyocytes via acting as an inhibitor of the MAPK14/p38 and MAPK8/JNK pathways, thereby regulating ventricular remodeling and cardiac rhythm post-myocardial infarction (PubMed:33746041). Negatively effects insulin sensitivity and promotes lipid formation in adipose tissues independent of CAMK2 signaling (PubMed:31327268). Interacts with CAMK2B; the presence of Ca(2+)/calmodulin increases the interaction but is not essential (By similarity). Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca(2+) (By similarity). Expressed in the brain (at protein level) (PubMed:17350603). Expressed in cardiomyocytes but not cardiac fibroblasts (at protein level) (PubMed:33746041). Up-regulated during retrieval and consolidation of fear memory (PubMed:16819996, PubMed:28642476). Down-regulated in brain during Japanese encephalitis virus (JEV) and rabies virus infection (PubMed:17010311). Knockout mice show normal growth rates (PubMed:33746041). Increased expression of inflammatory markers and enhanced recruitment of macrophages to the cardiac infarct border 3 days post-myocardial infarction (MI) (PubMed:33746041). Increased infarct size, interstitial fibrosis, and area of cardiac hypertrophy, leading to decreased left ventricular ejection fractions, fractional shortening and increased spontaneous ventricular arrhythmia at 28 days post MI (PubMed:33746041). Overall survival of mice following MI was significantly decreased (PubMed:33746041). In hippocampal knockdown mice, long-term retrieval-induced memory in response to contextual fear is impaired (PubMed:28642476). Increase in Camk2a T-296 autophosphorylation and Gria1/GluA1 abundance following conditioning and long-term memory retrieval (PubMed:28642476). Belongs to the CAMK2N family.