Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of mitochondrial Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (PubMed:29089435, PubMed:29420779). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). Plays a role during copper stress, in a manner dependent on the copper metalloregulatory transcription factor CUF1 (PubMed:29089435). Homodimer. Expression is positively regulated by CUF1 during copper stress. Increases susceptibility to copper toxicity and decreases fitness upon co-incubation with macrophage like cell lines (PubMed:29089435). Increases RNA level of genes involved in iron uptake (PubMed:29420779). Increases mitochondrial iron levels (PubMed:29420779). Increases mitochondrial reactive oxygen species (ROS) levels (PubMed:29420779). Increases mitochondrial complex I activity (PubMed:29420779). Decreases cellular heme levels (PubMed:29420779). Sensitive to hydrogen peroxide (PubMed:29420779). Abolishes cell population growth on the non-fermentable carbon source ethanol and acetate (PubMed:29420779). Decreases cell population growth rate; growth rate improves in a low oxygen environment (PubMed:29420779). Decreases virulence in a mouse intranasal infection model (PubMed:29420779). Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.