Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides. Isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells and vascular smooth muscle cells. Amidation of salusin-alpha(29-Gly) by peptidylglycine alpha-amidating monooxygenase, PAM, converts Lys-241-Gly-242 to Lys-241-NH2 and gives raise to salusin-alpha. Salusins -alpha and -beta peptides are derived from isoform 4. Belongs to the ClpA/ClpB family. Torsin subfamily.