Sequesters host STAT2 into viral inclusion bodies (Probable) (PubMed:29886262). Impairs IFN-stimulated phosphorylation and nuclear translocation of host STAT2, thereby suppressing type-I IFN antiviral signaling (Probable) (PubMed:29886262, PubMed:28680969). Sequesters host TRIM25, DDX58/RIG-I, TBK1/IKK complex components (TBK1, IKBKE/IKKE, and IRF3) and IRF7 into viral inclusion bodies, thereby inhibiting the IFN responses (Probable). Inhibits TRIM25-mediated ubiquitination of the DDX58/RIG-I (PubMed:32471869). The sequestration of IKBKE/IKKE, and IRF3 occurs via the interaction with TBK1 (PubMed:24335286). Sequestration and inhibition of host TBK1 probably participates to the cytokine storm induced by the virus (PubMed:33288641). Also inhibits the phosphorylation of host TBK1 (PubMed:28680969). Interacts with host TNIP2 and promotes TPL2-TNIP2-p105 complex formation leading to IL-10 induction (PubMed:30617349). By interacting with CDK1, induces host cell arrest at the G2/M transition to promote viral replication (PubMed:31852787). Requested for the formation of the viral cytoplasmic inclusion bodies (PubMed:24335286, PubMed:27226560). Interacts with the host E3 ubiquitin ligase TRIM25; this interaction sequesters TRIM25 in NSs-induced cytoplasmic inclusion bodies (PubMed:24478431, PubMed:32471869). Interacts with the host E3 ubiquitin ligase DDX58/RIG-I; this interaction sequesters DDX58/RIG-I in NSs-induced cytoplasmic inclusion bodies (PubMed:24478431). Interacts with the host E3 ubiquitin ligase TBK1 (via N-terminus); this interaction sequesters TBK1 in NSs-induced cytoplasmic inclusion bodies and inhibits TBK1 phosphorylation (PubMed:24478431, PubMed:24706939, PubMed:24335286, PubMed:30021900, PubMed:32471869). NSs does not interact with IKBKE/IKKE or IRF3 (PubMed:24335286). Interacts with host IRF7; this interaction sequesters IRF7 in NSs-induced cytoplasmic inclusion bodies (PubMed:30598516). Interacts with host SYNGR2; this interaction is essential to promoting the formation of the inclusion bodies to become virus factories for viral RNA replication through its interaction with NSs (PubMed:27226560). Interacts with host STAT2; this interaction sequesters STAT2 in NSs-induced cytoplasmic inclusion bodies (PubMed:29886262, PubMed:25631085) (Probable). Interacts with host TNIP2; this interaction promotes TPL2 complex formation and signaling activity leading to IL-10 production (PubMed:30617349). Interacts with host TRIM21 (via B30.2/SPRY domain); this interaction activates host NFE2L2-mediated transcriptional activation of antioxidant genes (PubMed:31852783). Interacts with host CDK1; this interaction is inclusion body dependent, it inhibits the formation and nuclear import of the cyclin B1-CDK1 complex and leads to host cell cycle arrest (PubMed:31852787). Localizes to the viral cytoplasmic occlusion bodies. Belongs to the Bandavirus NS-S protein family. PubMed:32471869 did not detect any interaction between NSs and host DDX58/RIG-I, nor NSs-induced sequestration of DDX58/RIG-I in cytoplasmic inclusion bodies.