Disease resistance protein of the TIR-NB-LRR-type. Part of the RPS6 locus that contains a cluster of several paralogous disease resistance (R) genes. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity). Required for [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione-(DFPM-) induced root growth arrest due to reduced number of meristem cells in the division zone of the primary root and inhibition of abscisic acid- (ABA-) induced stomatal closing. H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide Part of a nuclear protein complex made of VICTR, PAD4 and EDS1. Interacts (via TIR domain) with PAD4 and EDS1. By DFPM in the root meristematic zone. Induced by salicylic acid (SA). The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity. Loss of [5-(3,4-dichlorophenyl)furan-2-yl]-piperidine-1-ylmethanethione- (DFPM-) induced root growth arrest and inhibition of stomatal closing mediated by abscisic acid (ABA). Belongs to the disease resistance NB-LRR family.