Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of an acyl-carrier-protein. The enzyme is able to transfer the cofactor to a broad range of enzymes with acyl- or peptidyl-carrier protein domains. Required for primary biological processes such as growth and asexual/sexual development, and activates target enzymes involved in the synthesis of metabolites such as fatty acids, polyketides and nonribosomal peptides, lysine, siderophore, penicillin, sterigmatocystin, shamixantone, dehydroaustinol, and pigments. apo-[ACP] + CoA = adenosine 3',5'-bisphosphate + H(+) + holo-[ACP] Essential for growth. Belongs to the P-Pant transferase superfamily.