May modulate the Rho pathway signaling by providing a scaffold for the Lbc Rho guanine nucleotide exchange factor (ARHGEF1). Interacts with ARHGEF1. Widely expressed. Expressed at lower level in neural tissues and at the highest level in the adrenal gland. Down-regulated in cancer pancreatic cells undergoing differentiation and apoptosis. Belongs to the vinculin/alpha-catenin family.