Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity). Localizes to apical dendrite of pyramidal neurons. Expressed in spleen and brain by neurons and glial cells (at protein level). Expressed in lung, testis and thymus but not in heart, liver or kidney. Expressed in cerebellum, cortex and brainstem. Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor. Belongs to the G-protein coupled receptor 1 family.