Acts as a transcriptional activator (PubMed:18228599). Acts by binding to sequences related to the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes (PubMed:18228599). Involved in the auditory system development, required for terminal differentiation of hair cells in the inner ear (By similarity). Interacts with ISL1. Preferentially localized in the nucleus. Brain. Seems to be specific to the retina. The disease is caused by variants affecting the gene represented in this entry. Belongs to the POU transcription factor family. Class-4 subfamily. Gene page