ATP-dependent chaperone, which plays an essential role in the cytoplasmic maturation steps of pre-60S ribosomal particles by promoting the release of shuttling protein RSL24D1/RLP24 from the pre-ribosomal particles (PubMed:35354024). Acts together with SPATA5, C1orf109 and CINP (PubMed:35354024). ATP + H2O = ADP + H(+) + phosphate Associates with pre-60S ribosomal particles (PubMed:35354024). Interacts with C1orf109 (PubMed:35354024). Expressed in both neurons and glia during embryonic and adult stages of brain development. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the AAA ATPase family. AFG2 subfamily.