Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes. Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin. acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F Optimum pH is 7.8. Stable at 35 degrees Celsius. Rapid inactivation occurs at 50 degrees Celsius. Belongs to the acetyltransferase family. GNAT subfamily.