Acts as a critical modulator of FOXO3-induced autophagy via increased cellular ROS. May localize to aggresomes (PubMed:24530860). Expressed in various tissues, including pancreas, placenta, ovary, testis and kidney. High levels in first trimester deciduas. Higher levels in the endometria during secretory phase than the proliferative phase, especially after the mid-secretory phase. By progesterone, testosterone and, to a much lower extent, estrogen. Induced by oxidative stress via FOXO3 activation (PubMed:28545464). Up-regulated by hypoxia (at protein level).