May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. Optimum pH is 3.5-4.0. Highly expressed in liver, kidney, lung and skin. Detected in embryos of all developmental stages, with high level at the 7 day stage. Belongs to the glycosyl hydrolase 56 family.