Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B (PubMed:26990309). During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (PubMed:21881001). Interacts with CTNNB1, CTNNA1, PRKCI, PARD6B (By similarity). Interacts with FYB1. In undifferentiated cultured podocytes localizes to the perinuclear region and translocates to the cell membrane after Cadherin appearance at cell-cell contacts. Upon differentiation of cultured podocytes, protein disappears from cell contacts and expression ceases. Re-expressed upon induced podocyte injury. Colocalizes with FYB1 at cell-cell contacts in podocytes. Expressed in podocytes (at protein level). Expression in kidney peaks at postnatal day 4 and declines to undetectable levels by day 15. In adults very low expression detected in the basal region of lateral membranes of few tubule segments (at protein level). Belongs to the TMEM47 family.