High affinity iron permease required for iron uptake in iron-depleted environments (PubMed:15158278, PubMed:20545847). Required for full virulence in mice (PubMed:20545847). Expressed in iron-depleted conditions and repressed in iron-replete media (PubMed:15158278, PubMed:28610916). Induced during infection in diabetic ketoacidosis (DKA) mice (PubMed:20545847). Compromises the ability to acquire iron in vitro and reduced virulence in diabetic ketoacidosis (DKA) mice (PubMed:20545847). RNAi-mediated knockdown decreases virulence in a mouse model of 3-hydroxybutyric acid (BHB)-induced acidosis (PubMed:27159390). Passive immunization with anti-ftr1 immune sera protects DKA mice from infection (PubMed:20545847). Thus, ftr1 is a virulence factor and anti-ftr1 passive immunotherapy deserves further evaluation as a strategy to improve outcomes of deadly mucormycosis (PubMed:20545847). Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.