Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells. Proteolytic cleavage leads to an important conformation change. This reduces the affinity for steroids. N-glycosylated; binds 5 oligosaccharide chains. Glycosylation in position Asn-260 is needed for steroid binding. The disease is caused by variants affecting the gene represented in this entry. Belongs to the serpin family. Transcortin entry