IFN-induced antiviral protein which inhibits the entry of viruses to the host cell cytoplasm, permitting endocytosis, but preventing subsequent viral fusion and release of viral contents into the cytosol. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV) and West Nile virus (WNV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry and SARS-CoV S protein-mediated viral entry. Induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. Interacts with CD81. Predominantly expressed in nascent primordial germ cells, as well as in gonadal germ cells. From 5.5 dpc to 7.5 dpc expressed within the epiblast. At 8.5 dpc expressed throughout the entire embryo. Expressed in the gonadal germ cells at 11.5 dpc/12.5. Palmitoylation on membrane-proximal cysteines controls clustering in membrane compartments and antiviral activity. Phosphorylation at Tyr-19 is required for endosomal and lysosomal location. Belongs to the CD225/Dispanin family.