Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth. Interacts with ECM1. Interacts with TIMP3. Localizes to the lamina propria underneath the olfactory epithelium. Experimental confirmation may be lacking for some isoforms. In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina. The disease is caused by variants affecting the gene represented in this entry. Up-regulated in malignant gliomas. May increase glioma cell adhesiveness and invasive properties. Belongs to the fibulin family. Retina International's Scientific Newsletter