Required for the maturation and the transport from the endoplasmic reticulum to the plasma membrane of functional DUOX2. May play a role in thyroid hormone synthesis. Heterodimer with DUXA2; disulfide-linked. Specifically expressed in thyroid. Also detected in salivary glands. N-glycosylated. The disease is caused by variants affecting the gene represented in this entry. Belongs to the DUOXA family.