Acts downstream of PI3 kinase age-1 and kinase pdk-1 in the daf-2/insulin receptor-like transduction pathway (PubMed:15068796). Essential role in regulating development, stress response, and longevity (PubMed:15068796, PubMed:18782349). Phosphorylates Forkhead-related daf-16 and the longevity-promoting skn-1 transcription factors, which inhibits their entry into the nucleus and antagonizes their function (PubMed:18358814). Promotes the cytoplasmic localization of the transcription factor pqm-1 (PubMed:27401555). Plays a role in the intracellular trafficking of proteins such as mig-14 to the cell membrane, and this may be through positively regulating ceramide synthesis (PubMed:26115433). Acts downstream of rict-1 to regulate fat storage, size, development and vitellogenesis (PubMed:19240135, PubMed:19260765, PubMed:27401555). Downstream of age-1 and together with akt-1/2, promotes cell survival during embryonic development (PubMed:25383666). Does not appear to play a role in immune function (PubMed:18782349). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Phosphorylated and activated by pdk-1. Interacts with pdk-1, akt-1, akt-2 and daf-16 (PubMed:15068796). Part of a complex containing sgk-1, akt-1 and akt-2 (PubMed:15068796). Interacts with let-92 phosphatase regulatory subunit pptr-1 (PubMed:19249087). Localized both in the cytoplasm and in the nucleus in neurons, exclusively cytoplasmic in the intestine. Localizes to the apical cell membrane and diffusely throughout the cytoplasm in intestinal cells (PubMed:26115433). Expressed in late embryos just before hatching. At postembryonic stages, expressed in sensory and motor neurons and in the intestine. Highly expressed in the intestine and head and tail neurons (PubMed:26115433). A mild developmental delay, extended generation time, an extension of life span, defective egg-laying and decreased body size, but increased lipid storage (PubMed:15068796, PubMed:18782349, PubMed:19240135, PubMed:19260765). RNAi-mediated knockdown abolishes expression of the vitellogenin vit-3 (PubMed:27401555). Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.