Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze the modified nucleotides 5-methyl-UTP (m(5)UTP) and pseudo-UTP. Has weak activity with CTP (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). dTTP + H2O = diphosphate + dTMP + H(+) H2O + UTP = diphosphate + H(+) + UMP H2O + TTP = 5-methyl-UMP + diphosphate + H(+) H2O + psi-UTP = diphosphate + H(+) + psi-UMP kcat is 5.7 sec(-1) with dTTP as substrate. kcat is 2.6 sec(-1) with UTP as substrate. kcat is 1.2 sec(-1) with CTP as substrate. kcat is 2.2 sec(-1) with m(5)UTP as substrate. kcat is 5.3 sec(-1) with pseudo-UTP as substrate. Present with 1940 molecules/cell in log phase SD medium. Belongs to the Maf family. YhdE subfamily.