Expressed at 30 minutes post-infection during the period that most rickettsiae escape from phagosomal vacuoles into the host cytosol. Transformation of Salmonella with tlyC results in the escape of transformants from endosomal vacuoles into the host cell cytosol. According to PubMed:17301007, the hemolysin protein was detected only in the virulent strain ATCC VR-142 / Breinl and not in the avirulent strain Madrid E, at their current detection limit of 10 fmol. Belongs to the UPF0053 family. Hemolysin C subfamily.