Probable catalytic subunit of the Tip60 chromatin-remodeling complex. May acetylate nucleosomal histone H4 and H2A (PubMed:15068795). Acts in the determination of vulval and distal tip cell (DTC) precursor cell fates (PubMed:15068795, PubMed:20181741). acetyl-CoA + L-lysyl-[protein] = CoA + H(+) + N(6)-acetyl-L-lysyl-[protein] Autoacetylation at Lys-268 is required for binding histones with high affinity and for proper function. Belongs to the MYST (SAS/MOZ) family.