Transcriptional activator or repressor which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of globin genes and of other genes expressed in erythroid cells. Interacts with EP300; the interaction enhances transcriptional activity as a direct result of acetylation. Erythrocytes. The two fingers are functionally distinct and cooperate to achieve specific, stable DNA binding. The first finger is necessary only for full specificity and stability of binding, whereas the second one is required for binding (By similarity). Acetylated on Lys-158, Lys-214, Lys-218 and Lys-220 by EP300. Acetylation increases DNA binding and stimulates transcriptional activity.