Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681). Essential for sperm motility and is involved in the regulation of the beating frequency of motile cilia on the epithelial cells of the respiratory tract (PubMed:32376681). Required for the establishment of radial spokes in sperm flagella (PubMed:32376681). Expressed in the sperm, oviduct, lung, nasal cavity, brain ependyma and choroid plexus. Expressed in the sperm, oviduct, lung, nasal cavity, brain ependyma and choroid plexus. Expressed in the left-right organiser at embryonic day 8.0 dpc and at 17.5 dpc, expressed in the airway epithelia and brain ependymal tissues. Mice postnatally develop hydrocephalus, show impaired mucociliary clearance of the airways and are characterized by male infertility. Belongs to the CFAP206 family.