Protein 1A functions as a suppressor of RNA-mediated gene silencing, an antiviral defense mechanism of insect cells. Inhibits siRNA function, but does not interfere with miRNA pathway. Does not bind to dsRNA or siRNA. RNA-directed RNA polymerase replicates genomic and antigenomic RNA. a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) Interacts with host AGO2; this interaction may block the RNA-induced silencing complexes (RISC) activity. Protein 1A might be expressed through a ribosomal skip from one codon to the next without formation of a peptide bond.