acetyl-CoA + glyoxylate + H2O = (S)-malate + CoA + H(+) Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. There are two genes for malate synthase in C.tropicalis. The sequence shown is that of PMS1, PMS2 differs at a single position. Belongs to the malate synthase family.