Catalyzes the hydroxylation of tolbutamide and the N-demethylation of aminopyrine and benzphetamine. an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Specifically expressed by males in kidneys. Expressed predominantly by males in livers. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family.