Cell wall hydrolase that modulates cell division process (PubMed:22094151, PubMed:16942606). Probably acts by modulating FtsZ ring assembly (PubMed:16942606, PubMed:22094151). Murein hydrolase activity is targeted to sites of nascent peptidoglycan (PG) synthesis (PubMed:16942606). Overproduction compromises midcell localization of FtsZ rings, but has no effect on the intracellular levels of FtsZ (PubMed:16942606). Interacts with the cell division proteins FtsI and FtsQ. Localizes at poles and at midcell regions. Up-regulated in the presence of nitric oxide, reactive oxygen intermediates, mitomycin C, cephalexin or during growth in macrophages (PubMed:16942606). Expression is strongly DNA damage inducible independently of RecA (PubMed:16885473). Down-regulated under hypoxic growth conditions (PubMed:16942606). Mutants have stable FtsZ rings (PubMed:22094151). Deletion mutant is more sensitive to DNA damage (PubMed:16942606). Deletion of the gene causes a 10% increase in average cell length (PubMed:16942606). Loss of the gene does not influence the growth of M.tuberculosis in mice lungs and spleen (PubMed:22094151).