Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity). an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) Binds 1 copper ion per subunit. Binds 2 calcium ions per subunit. Contains 1 topaquinone per subunit. Homodimer; disulfide-linked (By similarity). Forms a heterodimer with AOC2 (By similarity). Highly expressed in adipocytes, aorta and lung. Expressed at lower levels in heart, kidney, large intestine, liver, small intestine and stomach. N- and O-glycosylated. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family.