May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (By similarity). Interacts with TGFB2 (By similarity). Interacts with BMP2 (By similarity). Interacts with FBN1 (via N-terminal domain) and FBN2 (PubMed:15131124). Associated with fibrillin-containing microfibrils of the developing nuchal ligament. Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils. Belongs to the MFAP family.