Chromatin-binding protein that acts as an adapter between distinct nucleosome components (H3K36me3 or H2A.Z) and chromatin-modifying complexes, contributing to the regulation of the levels of histone acetylation at actively transcribed genes (PubMed:30228260, PubMed:33235983). Competes with CHD4 and MBD3 for interaction with MTA1 to form a NuRD subcomplex, preventing the formation of full NuRD complex (containing CHD4 and MBD3), leading to recruitment of HDACs to gene promoters resulting in turn in the deacetylation of nearby H3K27 and H2A.Z (By similarity). Plays a role in facilitating transcriptional elongation and repression of spurious transcription initiation through regulation of histone acetylation (PubMed:30228260, PubMed:33235983). Essential for proper mitosis progression (By similarity). Component of a MTA1-specific subcomplex of the NuRD complex (M1HR), which is composed of PWWP2A, MTA1/2, HDAC1/2, and RBBP4/7 but does not contain CHD4 and MBD3 (By similarity). Interacts with MTA1; the interaction mediates the association of PWWP2A with the M1HR complex (By similarity). Interacts with H2A.Z/H2AZ1 (By similarity). Interacts (via PWWP domain) with histone H3 trimethylated at 'Lys-36' (H3K36me3) (By similarity). Does not interact with CHD4 and MBD3 (By similarity).