Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate (By similarity). Cleaves CoA, CoA esters and oxidized CoA with similar efficiencies (By similarity). Preferentially hydrolyzes medium-chain acyl-CoAs and bile acid-CoAs (By similarity). Has no activity toward NDP-sugars, CDP-alcohols, (deoxy)nucleoside 5'-triphosphates, nucleoside 5'-di or monophosphates, diadenosine polyphosphates, NAD, NADH, NADP, NADPH or thymidine-5'-monophospho-p-nitrophenyl ester (By similarity). May be required to eliminate oxidized CoA from peroxisomes, or regulate CoA and acyl-CoA levels in this organelle in response to metabolic demand (By similarity). Does not play a role in U8 snoRNA decapping activity (By similarity). Binds U8 snoRNA (By similarity). Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity). H2O + hexanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + hexanoyl-4'-phosphopantetheine H2O + octanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + S-octanoyl-4'-phosphopantetheine butanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-butanoyl-4'-phosphopantetheine decanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + decanoyl-4'-phosphopantetheine + 2 H(+) dodecanoyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-dodecanoyl-4'-phosphopantetheine H2O + tetradecanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + tetradecanoyl-4'-phosphopantetheine choloyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-choloyl-4'-phosphopantetheine 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-CoA + H2O = 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-26-oyl-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) acetyl-CoA + H2O = adenosine 3',5'-bisphosphate + 2 H(+) + S-acetyl-4'-phosphopantetheine CoA + H2O = (R)-4'-phosphopantetheine + adenosine 3',5'-bisphosphate + 2 H(+) H2O + propanoyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + propanoyl-4'-phosphopantetheine H2O + malonyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + malonyl-4'-phosphopantetheine H2O + succinyl-CoA = adenosine 3',5'-bisphosphate + 2 H(+) + succinyl-4'-phosphopantetheine a 5'-end CoA-ribonucleoside in mRNA + H2O = (R)-4'-phosphopantetheine + a 5'-end phospho-adenosine-phospho-ribonucleoside in mRNA + 2 H(+) Inhibited by fluoride. Monomer. Expressed in liver, kidney, pancreas, pituitary, small intestine, spleen, heart and placenta. Weakly expressed in brain. Belongs to the Nudix hydrolase family. PCD1 subfamily.