Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity). Interacts with F-actin (By similarity). Interacts with ANKRD54. Interacts with KBTBD10 (By similarity). Associated with the F-actin rich cortical cytoskeleton. Phosphorylated.