Involved in resistance to streptothricin, a broad-spectrum antibiotic produced by streptomycetes (PubMed:1850404). Detoxifies streptothricin via acetylation of the beta amino group of the first beta-lysyl moiety of streptothricin (By similarity). acetyl-CoA + streptothricin F = CoA + H(+) + N(beta)-acetylstreptothricin F Encoded in several related transposons, in (PubMed:2550905) encoded on an unnamed plasmid. Belongs to the acetyltransferase family. GNAT subfamily.