Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration. Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation. In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1. Binds MET and MST1R. Interacts with RIT2/RIN. Interacts (via cytoplasmic domain) with FSCN1 and RAC1. May form homodimers (via Sema domain) (By similarity). Interacts (via cytoplasmic domain) with ARHGDIA. Colocalizes with RIT2/RIN at the plasma membrane. Expressed in glioma cells (at protein level). Expressed in glioma cells and oligodendrocyte precursor cells. Belongs to the plexin family.