Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones (PubMed:9804427, PubMed:30397230). Involved in transcriptional repressiobn as part of the NuRD complex (PubMed:27068747). Required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity (PubMed:17626165). ATP + H2O = ADP + H(+) + phosphate Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressive complex (PubMed:9804427, PubMed:27068747). Interacts with TRIM28 (PubMed:11230151). Interacts with SERBP1 (PubMed:12505151). Interacts (via its C-terminal) with HABP4 (PubMed:12505151). Interacts with PCNT; the interaction regulates centrosome integrity (PubMed:17626165). Interacts with ZBED1/hDREF (PubMed:27068747). (Microbial infection) Interacts with Hantaan hantavirus nucleoprotein. (Microbial infection) Interacts with Seoul hantavirus nucleoprotein. Associates with centrosomes in interphase and mitosis. Widely expressed. Sumoylation at Lys-1971 results in dissociation from chromatin and suppression of transcriptional repression. The disease is caused by variants affecting the gene represented in this entry. One of the main antigens reacting with anti-MI-2 positive sera of dermatomyositis. Belongs to the SNF2/RAD54 helicase family. Differs from position 1967 onward for unknown reasons.