Involved in the regulation of endocytosis and in several stages of intracellular trafficking (PubMed:12668730, PubMed:17994011, PubMed:32513819, PubMed:33468622). Plays a role in recycling endocytosed transferrin receptor and prevent its degradation (PubMed:17994011). Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A (PubMed:32513819, PubMed:33468622). Heterodimer; heterodimerizes with SNX7 or SNX30 (PubMed:32513819). Interacts with WWC1/KIBRA (PubMed:17994011). Identified in a complex with WWC1/KIBRA and dynein components DYNLL1 and DYNC1I2 (PubMed:17994011). Interacts with BIN1 (PubMed:12668730). Also detected on a juxtanuclear endocytic recycling compartment (ERC). The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization. Belongs to the sorting nexin family.