Part of the Tip60 chromatin-remodeling complex which is involved in DNA repair (PubMed:15528408). Upon induction of DNA double-strand breaks, this complex acetylates phosphorylated H2AV in nucleosomes and exchanges it with unmodified H2AV (PubMed:15528408). During wing development, required for activity of Notch and its coactivator mam (PubMed:16508010). Function in promoting mam function is likely to involve both the Tip60 and SAGA complexes (PubMed:16508010). Component of the Tip60 chromatin-remodeling complex which contains the catalytic subunit Tip60 and the subunits Domino, Tra1, Brd8, E(Pc), DMAP1, Pontin, Reptin, Ing3, Act87E, BAP55, Mrg15, MrgBP, Gas41 and YL-1 (PubMed:15528408). Probable component of some SAGA complex (PubMed:12697829). Interacts with Spt3, Gcn5, Ada3 and Ada2b (PubMed:12697829). Ubiquitous. Expressed both maternally and zygotically. Although strongly related to the PI3/PI4-kinase family, it lacks the typical motifs that constitute the catalytic site of PI3/PI4-kinase proteins, suggesting that it probably lacks such activity. Belongs to the PI3/PI4-kinase family. TRA1 subfamily. Truncated N-terminus. Contaminating sequence. Insertion of several transposable element sequences.