Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process. This toxin acts on Nav1.2/SCN2A, Nav1.3/SCN3A and Nav1.6/SCN8A (EC(50)=1.7 uM). Expressed by the venom duct. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. The cysteine framework is VI/VII (C-C-CC-C-C). Monoisotopic mass. Monoisotopic mass. Found in the dissected venom (DV), but not in the injectable (milked) venom (IV). Does not have activity on rNav1.4/SCN4A, hNav1.5/SCN5A, Nav1.7/SCN9A, rNav1.8/SCN10A, DmNav1/para, Kv1.1/KCNA1, Kv1.3/KCNA3, Kv1.4/KCNA4, Kv1.5/KCNA5, Kv11.1/ERG1/HERG and shaker. Belongs to the conotoxin O1 superfamily.