Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:19877275, PubMed:19767740, PubMed:27158779). May regulate the morphogenesis of hair follicles which depends on functional primary cilia (PubMed:20962855). Interacts with CPLANE1. Interacts with INTU and WDPCP; FUZ, INTU and WDPCP probably form the core CPLANE (ciliogenesis and planar polarity effectors) complex. Expressed in dermal and epidermal cells. Embryonically lethal. Embryos display severe developmental defects, including neural tube closure defects, abnormal patterning of the spinal cord and the limb buds. They display polydactyly on all limbs and defects in skeletal development and organogenesis, including malformed sternum, ribs and long bones, as well as severely hypoplastic lungs and conotruncal defects. The number of hair follicles is also reduced. Defects in ciliogenesis are clearly noticed and result in abnormal hedgehog/smoothened signaling. Belongs to the fuzzy family.