When overexpressed kill the cells from the inside by interfering with a vital function in the cell membrane. Toxic component of a type I toxin-antitoxin (TA) system (By similarity). Toxic component of a type I toxin-antitoxin (TA) system (By similarity). When expressed is involved in cellular Mg(2+) release and degradation of stable RNA (PubMed:2465777). In the presence of rifampicin at 42 degrees Celsius. Belongs to the Hok/Gef family.