Required for the regulation of germline mitosis, karyosome formation, and establishment of dorsoventral (DS) polarity of the egg and embryo. Involved in proper grk mRNA localization and translation in the oocyte. May control germline mitosis by facilitating the cyclin E (CycE) proteolysis by the SCF-ubiquitin-proteasome complex. Interacts with hfp; however, given the nuclear localization of hfp, the relevance of such interaction is unclear. Interacts with CycE, Cul1, and the SCF-proteasome complex. Colocalizes with grk. Expressed in all germline cells of the germarium including the stem cells and dividing cystocytes. In the germarium, it begins to accumulate preferentially within the future oocyte shortly after formation of the 16-cell cyst. In midoogenesis, it can be seen transiently at the posterior edge of the oocyte, but by stage 9 assumes an anterior localization, and appears to be more concentrated at the dorsal side of the oocyte, above the oocyte nucleus. This pattern of localization is similar to that seen for grk mRNA and protein, though not tightly restricted to the dorsal side. Splicing donor and acceptor sites between exon 10 and exon 11 are not canonical. It is uncertain whether Met-1 or Met-143 is the initiator.