DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance. Interacts via its PTB domain with phosphorylated RET. Highly expressed in fetal and adult brain. Highly expressed in the cerebellum. Weak expression in kidney, spinal cord and testis. PTB domain mediates receptor interaction. On Ret activation, phosphorylated on one or more C-terminal tyrosine residues by an Src family kinase. Belongs to the DOK family. Type B subfamily.