Active against E.coli and Salmonella, but not Listeria or Campylobacter (PubMed:8058821, PubMed:27190283, PubMed:10396637). Channel-forming microcin (By similarity). Probably neutralized by its immunity protein McnI (Probable). Stable on heating to 80 degrees Celsius for 30 minutes, unstable at 100 degrees Celsius and to autoclaving. Induced during exponential growth in all media tested; activity remains in stationary phase, although expression varies depending on the growth medium (at protein level). Mass spectrometry suggests 3 of the 4 Met residues of the mature peptide are oxidized. When avirulent E.coli transformed with a plasmid encoding the genes necessary for microcin production, secretion and immunity is fed continuously to broiler chickens it significantly reduces the S.typhimurium load in the intestinal tract (PubMed:10396637). 44 of 57 reptile-derived Salmonella strains were sensitive in in vitro killing assays to the above strain, suggesting it might be used to reduce pet-acquired Salmonellosis (PubMed:11560267). Belongs to the class IIa microcin family. Extended N-terminus.