Toxic component of a probable type I toxin-antitoxin (TA) system. Neutralized by sRNA antitoxin TimR which binds to the 5' UTR of timP mRNA and inhibits translation. When TimP is expressed from its promoter in the absence of antitoxin leads to mild cell stress; overexpression in situ is toxic to the cell and causes membrane leakage. The antitoxin gene is encoded immediately upstream and transcribed divergently from the toxin gene; antitoxin RNA is less stable than timP mRNA. The signal sequence is not cleaved and anchors the protein in the cell inner membrane. Expressed under many growth conditions, up-regulated in macrophages. No changes in biofilm formation, persister cell formation or bacteriophage resistance; no visible phenotype for a double timR-timP deletion. A timR deletion leads to mild envelope stress. Belongs to the TimP toxin family.