In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli. Highly expressed in kidney, also detected on liver and spleen (PubMed:27599751). Expressed by proximal tubular cells of the kidney (at protein level) (PubMed:27599751). Expression highly increases during chronic kidney disease and autosomal dominant polycystic kidney disease, where is detected in cysts (PubMed:27599751). Over-expressed in centenarians. Expression is reduced from young to old but increased from old to centenarians. Expression is induced by TGFB1, in kidney tubular cells. This induction is inhibited by the vitamin D receptor activator paricalcitol (at protein level). Disease susceptibility may be associated with variants affecting the gene represented in this entry. Contaminating sequence. Potential poly-A sequence. Contaminating sequence. Potential poly-A sequence. Contaminating sequence. Potential poly-A sequence.