Member of the two-component regulatory system QseF/QseE involved in the regulation of virulence and metabolism in EHEC. Required for pedestal formation in host epithelial cells during infection. Autophosphorylates in response to epinephrine, sulfate or phosphate and then probably transfers its phosphate group to QseF. ATP + protein L-histidine = ADP + protein N-phospho-L-histidine. Induced by epinephrine during late exponential growth, probably via the QseC sensor. Autophosphorylated. Mutants can still form pedestals. Extended N-terminus. Extended N-terminus.