Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine) (By similarity). Acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation (By similarity). Shows no activity against histone H3 when it is trimethylated on 'Lys-9' (H3K9me3) or 'Lys-27' (H3K27me3) or when 'Lys-4' is monomethylated (H3K4me1) or dimethylated (H3K4me2) (By similarity). Also mediates deamination of methylated TAF10, a member of the transcription factor IID (TFIID) complex, which induces release of TAF10 from promoters, leading to inhibition of TFIID-dependent transcription (By similarity). LOXL2-mediated deamination of TAF10 results in transcriptional repression of genes required for embryonic stem cell pluripotency (By similarity). Involved in epithelial to mesenchymal transition (EMT) and participates in repression of E-cadherin, probably by mediating deamination of histone H3 (By similarity). When secreted into the extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (By similarity). Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding (PubMed:21835952). Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation (By similarity). Required with loxl2b for correct expression of Sox2 and for neural differentiation (PubMed:25959397). H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4(+) Contains 1 lysine tyrosylquinone. Associated with chromatin. It is unclear how LOXL2 is nuclear as it contains a signal sequence and has been shown to be secreted. However, a number of reports confirm its intracellular location and its key role in transcription regulation. Expression increases between 20 and 48 hours after fertilization and is detected in sprouting intersegmental vessels (PubMed:21835952). At 24 hours after fertilization, expressed throughout the embryo with high levels in eye, mesencephalon and hindbrain boundaries (PubMed:25959397). The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. Morpholino knockdown in the embryo prevents the formation of intersegmental blood vessels (PubMed:21835952). Morpholino knockdown of loxl2a and loxl2b in the embryo results in increased expression of Sox2 in the central nervous system, particularly in the eye, hindbrain and spinal cord (PubMed:25959397). It also leads to impaired neural differentiation with morphological defects in the brain where the anterior brain is rounder than normal and the eyes present a flatter curvature (PubMed:25959397). Embryo development is also compromised (PubMed:25959397). Belongs to the lysyl oxidase family.