Plays a role in endocytosis and regulates internalization of plasma membrane proteins. Overexpression impairs internalization of SLC2A1/GLUT1 and TRPV4 and increases the levels of SLC2A1/GLUT1 and TRPV4 at the cell membrane. Inhibits the TRPV4 calcium channel activity. Homodimer. May form heterooligomers with other PACSINs. Interacts (via SH3 domain) with DNM1, SYNJ1 and WASL. Interacts with TRPV4. Detected at the inner aspect of the plasma membrane in myotubes. Highly expressed in skeletal muscle, heart and lung; also detected in brain, kidney and uterus (at protein level). The F-BAR domain forms a coiled coil and mediates membrane-binding and membrane tubulation. Phosphorylated by casein kinase 2 (CK2) and protein kinase C (PKC). Belongs to the PACSIN family.