Plays a key role in glycolysis and gluconeogenesis. beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4. Homotetramer. A number of isoforms are produced. According to EST sequences. Highly expressed in rosettes leaves and cauline leaves. By sucrose (PubMed:22561114). Induced by drought stress (PubMed:22561114). Can be trimethylated at Lys-395 by LSMT-L, but the trimethylation has no effect in vitro on the kinetic properties of the enzyme. S-glutathionylated. Belongs to the class I fructose-bisphosphate aldolase family.