Exhibits strong synaptogenic activity, restricted to excitatory presynaptic differentiation, acting at both pre- and postsynaptic level. Predominantly expressed in forebrain regions including thalamus and cerebral cortex. This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated paternally with handedness and schizophrenia. Belongs to the LRRTM family. The hands to say it - Issue 91 of February 2008