Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). Heterodimer with MEIS1 (PubMed:28473536). Heterodimer with MEIS2 (Ref.8). Disease susceptibility is associated with variants affecting the gene represented in this entry. Belongs to the Abd-B homeobox family.