Acts on ADP-mannose and ADP-glucose as well as ADP-ribose. Prevents glycogen biosynthesis. The reaction catalyzed by this enzyme is a limiting step of the gluconeogenic process (By similarity). ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) Binds 3 Mg(2+) ions per subunit. Inhibited by phosphorylated compounds such as AMP, ADP, ATP, 3-phosphoglyceric acid and PPi. Not inhibited by orthophosphate. Activity is high in cells grown in low glucose concentrations and decreases dramatically as glucose concentration increases (By similarity). Homodimer. Belongs to the Nudix hydrolase family. NudF subfamily.