Catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+). NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal Cofactor degradation; B6 vitamer degradation; pyridoxal from pyridoxine (dehydrogenase route): step 1/1. Present with 2190 molecules/cell in log phase SD medium. Belongs to the aldo/keto reductase family.