This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction (By similarity). Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (By similarity). Interacts (via IQ domain) with calmodulin (By similarity). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity). Cytoplasmic surface of growth cone and synaptic plasma membranes. Expressed in hippocampal neurons, with highest levels of expression in the CA4 and CA3 neurons and lower levels in CA1 neurons (PubMed:11948657, PubMed:17577668). Expressed in the dorsal root ganglion (PubMed:12957493). Expression in dentate granule cells of the hippocampus at postnatal day P5, with disappearing expression in dentate granule cells as early as P14. Up-regulated by kainic acid-induced seizures (PubMed:17577668). Up-regulated after axotomy (PubMed:12957493). Phosphorylated (PubMed:1533624, PubMed:8454596, Ref.13). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (PubMed:1533624, PubMed:8454596, Ref.13). Palmitoylated by ZDHHC3 (By similarity). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity). Belongs to the neuromodulin family.