Catalyzes the dioxygenolytic ring cleavage of 2,5-dihydroxypyridine between carbons 5 and 6 generating N-formylmaleamate in the aerobic nicotinate degradation pathway. 2,5-dihydroxypyridine + O2 = H(+) + N-formylmaleamate Cofactor degradation; nicotinate degradation. Cells lack 2,5-dihydroxypyridine 5,6-dioxygenase activity.