Functions as a chaperone necessary for a stable expression of the CYBA and CYBB subunits of the cytochrome b-245 heterodimer (PubMed:30361506). Controls the phagocyte respiratory burst and is essential for innate immunity (By similarity). Interacts with CYBB; CYBC1 may act as a chaperone stabilizing Cytochrome b-245 heterodimer. Highly expressed in macrophages, neutrophils and monocytes. In macrophages, expression is induced after treatment with IFNG or a combination of IFNG and Salmonella Tiphimurium. The disease is caused by variants affecting the gene represented in this entry. Belongs to the CYBC1 family. Wrong choice of frame.