Involved in the biosynthesis of rubber, an isoprenoid polymer (cis-1,4-polyisoprene). Auto-assembles in solution into stable nanomultimers of a globular nature. Found in latex, the cytoplasm of laticifer cells. Tightly bound to small rubber particles, where it displays a covering effect on the lipid headgroups of the membrane without disturbing its integrity. Highly expressed in the specialized vessel laticifers, but localized only in the laticifer layers in the conducting phloem (PubMed:10358068, PubMed:19415323). Also detected in leaves (PubMed:10358068). Induced by tapping (PubMed:12461132). Not induced by wounding, ethephon or abscisic acid treatment (PubMed:12461132). Induced by ethylene (PubMed:22162870). Not glycosylated. The N-terminus is blocked. Consistent shifts of about 266 Da observed by MS in various forms of the intact protein suggest the addition of stearolyl groups. Causes an allergic reaction in human. Involved in latex allergic reactions. Major spina bifida (SB) associated latex allergen. Patients with SB are especially sensitive to specific allergens that do not usually affect adult patients without SB who are otherwise sensitive to latex. These patients are multioperated patients, whose mucosal membranes have been frequently in contact with latex products. Many patients with SB are sensitized to low molecular weight polypeptides derived from the fragmentation of Hev b 3. Belongs to the REF/SRPP family. Gloves, condoms and bouncy balls - Issue 13 of August 2001