May be involved in vasopressin signaling in the kidney. Homooligomer (By similarity). Interacts (via SAM domain) with ANKS6 (via SAM domain) (PubMed:25671767). Interacts with BICC1 (By similarity). Interacts with NPHP1 (By similarity). Interacts with NEK8 (By similarity). Interacts with HIF1AN (By similarity). Interacts with NEK7; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (By similarity). The SAM domain mediates homooligomerization. Hydroxylated at Asn-96, most probably by HIF1AN. Phosphorylations at Ser-5, Ser-225, Thr-318, Ser-319, Ser-366 and Ser-369 occur in a NEK7-dependent manner. Polyubiquitinated.