Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring (PubMed:15588826, PubMed:17307979, PubMed:1856163, PubMed:19651913, PubMed:2327760). It is able to hydrolyze penicillin and imipenem, but is much less active against cephalothin, cefotaxime, meropenem and ceftazidime (PubMed:1856163, PubMed:2327760). a beta-lactam + H2O = a substituted beta-amino acid Binds 1 Zn(2+) ions per subunit. Competitively inhibited by mercaptophosphonate and pyridine carboxylate derivatives (PubMed:17307979, PubMed:20527888). Also inhibited by the binding of a second zinc ion and by chelating agents such as EDTA (PubMed:1856163, PubMed:2327760, PubMed:19651913). kcat is 1200 sec(-1) for lactamase activity with imipenem as substrate (PubMed:15588826, PubMed:19651913). kcat is 300 sec(-1) for lactamase activity with biapenem as substrate (PubMed:15588826). kcat is 210 sec(-1) for lactamase activity with imipenem as substrate (at pH 7) (PubMed:17307979). kcat is 140 sec(-1) for lactamase activity with imipenem as substrate (at pH 8) (PubMed:17307979). kcat is 49 sec(-1) for lactamase activity with imipenem as substrate (at pH 9) (PubMed:17307979). kcat is 0.008 sec(-1) for lactamase activity with nitrocefin as substrate (PubMed:19651913). Monomer. By either cefoxitin or imipenem. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.