Catalyzes the direct conversion of aminodeoxyfutalosine (AFL) into dehypoxanthine futalosine (DHFL) and adenine via the hydrolysis of the N-glycosidic bond; this reaction seems to represent an essential step in the menaquinone biosynthesis pathway in Campylobacter species. Also catalyzes the hydrolysis of 5'-methylthioadenosine (MTA) to adenine and 5'-methylthioribose. Can also probably use S-adenosylhomocysteine (SAH) as substrate, leading to adenine and S-ribosylhomocysteine. These other activities highlight the tremendous versatility of the enzyme, which also plays key roles in S-adenosylmethionine recycling and in the biosynthesis of the quorum-sensing molecule autoinducer-2. Shows negligible activity with futalosine (FL) as substrate. 6-amino-6-deoxyfutalosine + H2O = adenine + dehypoxanthine futalosine H2O + S-adenosyl-L-homocysteine = adenine + S-(5-deoxy-D-ribos-5-yl)-L-homocysteine H2O + S-methyl-5'-thioadenosine = 5-(methylsulfanyl)-D-ribose + adenine 5'-deoxyadenosine + H2O = 5-deoxy-D-ribose + adenine kcat is 0.53 sec(-1) with aminodeoxyfutalosine as substrate. kcat is 2.7 sec(-1) with 5'-methylthioadenosine as substrate. Quinol/quinone metabolism; menaquinone biosynthesis. Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'-thioadenosine (hydrolase route): step 1/2. Homodimer. Belongs to the PNP/UDP phosphorylase family.