Involved in regulation of lifespan (PubMed:17411345). Required for dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876). Inhibits the skn-1-mediated up-regulation of tatn-1 (PubMed:31043480). Increased lifespan (PubMed:17411345). RNAi-mediated knockdown significantly prevents Mn(2+)-induced dopaminergic CEP neuron degeneration (PubMed:23721876). RNAi-mediated knockdown increases tatn-1 expression and enzymatic activity (PubMed:31043480). Belongs to the WD repeat LEC14B family.