Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Interacts with MDM4 (phosphorylated); negatively regulates MDM4 activity toward TP53. Interacts with RAF1, SSH1 and CRTC2/TORC2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with GAB2, SAMSN1 and SIRT2 (By similarity). Interacts with PKA-phosphorylated AANAT. Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB, TBC1D22A and TBC1D22B (By similarity). Interacts with SLITRK1 (By similarity). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity). Interacts with MARK2 and MARK3 (By similarity). Interacts with MEFV (By similarity). Interacts with ENDOG, TSC2 and PIK3C3; interaction with ENDOG weakens its interaction with TSC2 and PIK3C3 (By similarity). Interacts with TH (phosphorylated form); one YWHAG dimer bounds to one TH tetramer, this interaction may influence the phosphorylation and dephosphorylation of TH (By similarity). Localized in neurons, and axonally transported to the nerve terminals. May be also present, at lower levels, in various other tissues. Phosphorylated by various PKC isozymes. Belongs to the 14-3-3 family.