Ribonuclease which shows a preference for the pyrimidines uridine and cytosine (PubMed:3926759). Has potent antimicrobial activity against a range of Gram-positive and Gram-negative bacteria, including P.aeruginosa, A.baumanii, M.luteus, S.aureus, E.faecalis, E.faecium, S.saprophyticus and E.coli (By similarity). Causes loss of bacterial membrane integrity, and also promotes agglutination of Gram-negative bacteria (By similarity). Probably contributes to urinary tract sterility (By similarity). Bactericidal activity is independent of RNase activity (By similarity). Optimum pH is 6.5. Optimum temperature is 30 degrees Celsius. Activity declines with increasing temperature, with loss of stability at 90 degrees Celsius. Interacts (via N-terminus) with bacterial lipopolysaccharide (LPS). Kidney (at protein level). Belongs to the pancreatic ribonuclease family.