Binds specifically to calcyclin in a calcium-dependent manner. Required for midbody formation and completion of the terminal phase of cytokinesis. Interacts with PDCD6 in a calcium-dependent manner (By similarity). Interacts with KIF23 during cytokinesis (By similarity). Isoform 1 but not isoform 2 interacts with S100A6. Found throughout the nucleoplasm at interphase and during mitosis concentrates around the mitotic apparatus. Elevation of intracellular calcium causes relocalization from the nucleoplasm to the nuclear envelope, with little effect on the cytoplasmic pool. Localization to the nuclear envelope is cell-cycle dependent. Expressed in a wide variety of tissues. A pair of annexin repeats may form one binding site for calcium and phospholipid. Belongs to the annexin family. The subcellular location study was carried out using a rat fibroblast cell line.