H2O + L-glutamate + NAD(+) = 2-oxoglutarate + H(+) + NADH + NH4(+) H2O + L-glutamate + NADP(+) = 2-oxoglutarate + H(+) + NADPH + NH4(+) Subject to allosteric regulation. Activated by AMP and ADP. Optimum pH is 7.25 to 7.5. Homohexamer. ADP can occupy the NADH binding site and activate the enzyme. Belongs to the Glu/Leu/Phe/Val dehydrogenases family.