The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. Also functions as a receptor for bacterial chemotaxis and is required for infection of the cell by bacteriophage lambda where it most likely functions as a pore for penetration of lambda DNA. Homotrimer of protomers that are composed of two subunits, IIC and IID. Transcriptionally regulated by the Mlc transcriptional repressor and by the cAMP-CRP complex. Also weakly repressed by NagC. The EIID domain, with its homologous EIIC domain, forms the PTS system translocation channel and contains part of its specific substrate-binding site. Extended N-terminus. Extended N-terminus.