Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins. May have a role in membrane trafficking. Interacts with RII subunit of PKA. Associated with pleomorphic tubulovesicular endomembranes near the trans sides of Golgi stacks and throughout the cell bodies and cell processes. Concentrated at the postsynaptic plasma membrane of a subpopulation of synapses. Forebrain, brainstem and cerebellum. Highly expressed in neonatal brain, levels decline in adults. RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer. Belongs to the WD repeat neurobeachin family.