In hippocampal neurons, regulates dendritic and spine growth and synaptic transmission. Interacts with CTCF, MYO1C and with the transcriptional machinery, including RNA polymerase II and TBP. Cell-permeable protein. 22 hours after injection in the hippocampal area CA1, internalized by most cells at the injection site (PubMed:26961175). Localizes at the chromosome periphery during mitosis (By similarity). Widely expressed, with high levels in testis and spleen and low levels in heart. In the brain, expressed in the cortex and hippocampus, and at very low levels in the cerebellum. Strongly expressed in the brain in early developmental stages. Expression gradually decreases during development, from very high levels at 13 dpc down to hardly detectable in the adult at day 20 postnatal and later on (at protein level). In the hippocampal neurons, down-regulated by sustained activity induced by increased extracellular potassium concentration for a prolonged time (2 - 5 hours) (at protein level). Belongs to the learning-associated protein family.