Catalyzes the dehalogenation of halotyrosines such as 3,5-diiodo-L-tyrosine (PubMed:24153409). Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH kcat 4.1 min(-1) for the deiodination of diiodotyrosine (L-DIT). Belongs to the nitroreductase family.