Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of bifonsecin B, a dimeric gamma-naphthopyrone (PubMed:31067027). The first step in the biosynthesis of bifonsecin B is the production of gamma-naphthopyrone precursor YWA1 by the non-reducing polyketide synthase albA, via condensation of one acetyl-CoA starter unit with 6 malonyl-CoA units (PubMed:31067027). YWA1 is then methylated by bfoE at position C-6 to yield foncesin which is further methylated at position C-8 by bfoD to produce fonsecin B (Probable). A key enzyme in the biosynthetic pathway is the cytochrome P450 monooxygenase bfoB which catalyzes the oxidative dimerization of fonsecin B to bifonsecin B (PubMed:31067027). Bfob also catalyzes the oxidative dimerization of rubrofusarin B into nigerone (PubMed:31067027). The stereoselectivity of bfoB is influenced by the two natural monomeric substrates; homodimerization of fonsecin B yields a stereochemically pure biaryl, M-foncerine B, while rubrofusarin B yields a mixture of enantiomers M- and P-nigerone (PubMed:31067027). 2 fonsecin B + H(+) + NADPH + O2 = bifonsecin B + 2 H2O + NADP(+) 3 H(+) + NADPH + O2 + 2 rubrofusarin B = 2 H2O + NADP(+) + nigerone Secondary metabolite biosynthesis. Belongs to the cytochrome P450 family.