Activator for CDC42 by directly engaging this Rho GTPase and acting as potent guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling, promoting bacterial entry into non-phagocytic cells. Also activates NF-kB, p38 and ERK kinases, which are known to be involved in the induction of IL-8 expression. Chaperone InvB is required for secretion, translocation and stabilization of intracellular levels of sopE2. Secreted via the type III secretion system 1 (SPI-1 TTSS). SopE2 is highly conserved among Salmonella isolates of the SARA collection. Belongs to the GEF (guanine exchange factor) SopE family.