Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Interacts with IL8. Interacts with GNAI2. Expressed preferentially in neutrophils. Phosphorylated upon ligand binding; which is required for desensitization. Belongs to the G-protein coupled receptor 1 family.