Component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). UME6 controls the level and duration of gene expression in the filamentous growth program such as HGC1; and is specifically important for hyphal elongation and germ tube formation. Promotes filamentous biofilms and is required for adherence to surfaces such as plastic. Plays an important role in virulence. Component of the RPD3C(L) complex. Up-regulated during growth in alkaline conditions, in response to various filament-inducing conditions, and during oropharyngeal candidiasis. Induced in both white and opaque cells. Induced by SFL2 and repressed by RFG1, SFL1, and by NRG1 under non-filament-inducing conditions. Also repressed by linalool. Expression is also regulated by BRG1 and EFG1. Leads to attenuated virulence and defective hyphal extension in a mouse model of systemic candidiasis.