Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. (R)-4'-phosphopantetheine + ATP + H(+) = 3'-dephospho-CoA + diphosphate Is inhibited by a series of cycloalkyl pyrimidines, which also show suppression of bacterial growth. Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. Homohexamer. PPAT is a validated novel target for antibacterial therapy against Gram-positive bacteria. Belongs to the bacterial CoaD family.