One of the virulence factors of A.pleuropneumoniae, which shows a weak hemolytic activity and is moderately cytotoxic for alveolar macrophages and neutrophils. The Gly-rich region is probably involved in binding calcium, which is required for target cell-binding or cytolytic activity. The three transmembrane domains are believed to be involved in pore formation by the cytotoxin. Palmitoylated by ApxIIC. The toxin only becomes active when modified (By similarity). Belongs to the RTX prokaryotic toxin (TC 1.C.11) family.