Oxidizes medium and long chain saturated and unsaturated aldehydes (PubMed:25286108). Metabolizes also benzaldehyde (By similarity). Low activity towards acetaldehyde and 3,4-dihydroxyphenylacetaldehyde (By similarity). May not metabolize short chain aldehydes. Can use both NADP(+) and NAD(+) as electron acceptor (By similarity). May have a protective role against the cytotoxicity induced by lipid peroxidation (By similarity). an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH an aldehyde + H2O + NADP(+) = a carboxylate + 2 H(+) + NADPH 2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+) H2O + NAD(+) + octanal = 2 H(+) + NADH + octanoate H2O + NADP(+) + octanal = 2 H(+) + NADPH + octanoate benzaldehyde + H2O + NADP(+) = benzoate + 2 H(+) + NADPH benzaldehyde + H2O + NAD(+) = benzoate + 2 H(+) + NADH H2O + hexanal + NADP(+) = 2 H(+) + hexanoate + NADPH (E)-4-hydroxynon-2-enal + H2O + NADP(+) = (E)-4-hydroxynon-2-enoate + 2 H(+) + NADPH (2E)-octenal + H2O + NADP(+) = (2E)-octenoate + 2 H(+) + NADPH (2E)-octenal + H2O + NAD(+) = (2E)-octenoate + 2 H(+) + NADH Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2. Primarily in the plasma membrane as well as in some punctate structures in the cytoplasm. Highly expressed in kidney and liver. In brain is expressed at moderate levels in cortex, striatum and hippocampus, and at lower levels in brainstem and cerebellum. Dually lipidated in the C-terminus; prenylation occurs prior to, and is a prerequisite for palmitoylation. It is also required for activity towards long-chain substrates. Belongs to the aldehyde dehydrogenase family.