Component of a mechanosensitive cation channel. Confers mechanically activated (MA) currents with slow inactivation kinetics. May contribute to proprioception (PubMed:27321926). Localizes at the plasma membrane. A portion co-localizes with LAMP1 lysosomal marker. High expression in the epididymis, pancreas, dorsal-root ganglion, eye, brain, and spinal cord. Expressed in muscle spindle afferents (at protein level)(PubMed:27321926). Deficient mice exhibit loss of coordinated movements and abnormal gait. Tentonin comes from the Greek 'tentono' meaning to stretch. Belongs to the DRAM/TMEM150 family. The function of the TMEM150C complex is debated. One study confirms that naive cells expressing TMEM150C is activated by mechanically stimuli but this response is absent in CRISPR-Cas9 PIEZO1 knockout cell lines suggesting that TMEM150C is not sufficient to function as mechanically activated channels but is a modulatory protein of PIEZO1 (PubMed:28426961). In another study, based on coexpression of TMEM150C and PEIZO1 and mutant variants of TMEM150C supports that TMEM150C is a pore-forming unit, and not an amplifying adapter for PIEZO1 activity (PubMed:28426962). Extended N-terminus.