Acyl-coenzyme A (acyl-CoA) thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Contributes to growth on fatty acids. H2O + hexadecanoyl-CoA = CoA + H(+) + hexadecanoate Up-regulated by oleic acid. Belongs to the C/M/P thioester hydrolase family.