Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. Benzylpenicillin is a better substrate than cephalosporin C and ampicillin (PubMed:3131315, PubMed:2501295). a beta-lactam + H2O = a substituted beta-amino acid Binds 2 Zn(2+) ions per subunit. Inhibited by chelating agents such as EDTA. Thermostable. Monomer. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.