G protein-coupled receptor that is activated by the chemokine CCL5/RANTES. Probably coupled to heterotrimeric Gq proteins, it stimulates inositol trisphosphate production and calcium mobilization upon activation. Together with CCL5/RANTES, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. CCL5/RANTES may also regulate insulin secretion by pancreatic islet cells through activation of this receptor. Highly expressed in brain and heart. Also detected in skeletal muscle, liver and kidney. Also expressed by islet cells (at protein level). Expressed at 7 dpc and 11 dpc. Also detected at 17 dpc. Belongs to the G-protein coupled receptor 1 family. Truncated N-terminus.