Required for programmed cell death (PCD) associated with hypersensitive response (HR). Involved both in the induction of EDS1/PAD4 mediated HR and in accelerated cell death in the acd11 mutant. Not required for HR induction elicited through pathways exclusively dependent on CC-NB-LRR resistance proteins. Suppresses acd11-dependent cell death. Laz1 acd11 double mutants survive throughout development to flower and set seeds, in contrast to the fate of acd11. Belongs to the TMEM184 family.