Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids without apparent head group selectivity (PubMed:20424323). Contributes to phospholipid remodeling of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles. Hydrolyzes LDL phospholipids releasing unsaturated fatty acids that regulate macrophage differentiation toward foam cells (By similarity). May act in an autocrine and paracrine manner (PubMed:23624557). Secreted by immature mast cells, acts on nearby fibroblasts upstream to PTDGS to synthesize prostaglandin D2 (PGD2), which in turn promotes mast cell maturation and degranulation via PTGDR (PubMed:23624557). Secreted by epididymal epithelium, acts on immature sperm cells within the duct, modulating the degree of unsaturation of the fatty acyl components of phosphatidylcholines required for acrosome assembly and sperm cell motility (PubMed:20424323). Facilitates the replacement of fatty acyl chains in phosphatidylcholines in sperm membranes from omega-6 and omega-9 to omega-3 polyunsaturated fatty acids (PUFAs) (PubMed:20424323). Coupled to lipoxygenase pathway, may process omega-6 PUFAs to generate oxygenated lipid mediators in the male reproductive tract (PubMed:20424323). At pericentrosomal preciliary compartment, negatively regulates ciliogenesis likely by regulating endocytotic recycling of ciliary membrane protein (By similarity). Coupled to cyclooxygenase pathway provides arachidonate to generate prostaglandin E2 (PGE2), a potent immunomodulatory lipid in inflammation and tumorigenesis (By similarity). At colonic epithelial barrier, preferentially hydrolyzes phospholipids having arachidonate and docosahexaenoate at sn-2 position, contributing to the generation of oxygenated metabolites involved in colonic stem cell homeostasis (PubMed:28947740). Releases C16:0 and C18:0 lysophosphatidylcholine subclasses from neuron plasma membranes and promotes neurite outgrowth and neuron survival (PubMed:17868035). a 1,2-diacyl-sn-glycero-3-phosphocholine + H2O = a 1-acyl-sn-glycero-3-phosphocholine + a fatty acid + H(+) 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphocholine + H(+) 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine + H2O = (9Z,12Z)-octadecadienoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine + H2O = (5Z,8Z,11Z,14Z)-eicosatetraenoate + 1-hexadecanoyl-sn-glycero-3-phosphoethanolamine + H(+) Binds 1 Ca(2+) ion. Localized at pericentrosomal preciliary compartment. Expressed in dermal mast cells (at protein level) (PubMed:23624557). Highly expressed in EPCAM-positive colonic epithelial cells throughout the proximal to distal colon (at protein level) (PubMed:28947740). Expressed at lower levels in ileum section of small intestine and immune organs including bone marrow, spleen and lymph nodes (PubMed:28947740, PubMed:20424323). Expressed in stomach and lung (at protein level) (PubMed:17868035). Expressed in testis and epididymis and to a lesser extent in the seminal vesicles and prostate (PubMed:20424323). Detected in ovary, oviduct and uterus (PubMed:20424323). Expressed in Sertoli and Leydig cells as well as in epididymal epithelium particularly in apical border of principal cells in the corpus (at protein level) (PubMed:20424323). Present in cauda epididymal fluid (at protein level) (PubMed:20424323). Expressed in central nervous system, with high levels in spinal cord and at a lesser extent in brain (at protein level) (PubMed:17868035, PubMed:20424323). Highly expressed in dorsal root ganglia of the developing brain at 12.5 dpc (at protein level). The phospholipase A2-like domain represents the fully processed form after N- and C-termini are cleaved off. It is the secreted mature form found in biological fluids. N-glycosylation does not affect the catalytic activity, but is required for proper secretion. A nonglycosylated form is observed in several cell types. In several cell types, the N- and C-termini are cleaved off. Male mutant mice have reduced fertility associated with reduced sperm cell motility, aberrant acrosomes and flagella resulting in poor morula development. The litter size after intercrossing heterozygous mutant male and female mice is significantly smaller when compared to wild-type mice. Nevertheless, mutant offspring are born at approximately Mendelian proportions, have normal survival, appearance and behavior (PubMed:20424323). Mutant mice are resistant to both passive systemic and active cutaneous anaphylaxis (PubMed:23624557). In models of colon carcinogenesis either induced by azoxymethane procarcinogen or upon activation of oncogenic Wnt/beta-catenin signal due to a mutation in the APC gene (model of human familial adenomatous polyposis), mutant mice are resistant to tumorigeneis showing markedly decreased total tumor burden in the colon. In a colitis model induced by toxic dextran sulfate sodium, mutant mice are protected from shortening of the colon length and mucosal inflammation and rapidly recover from epithelial injury (PubMed:28947740). Belongs to the phospholipase A2 family.