The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II PtfABC PTS system is involved in fructose transport. Expression is highly up-regulated in presence of fructose. The EIIC type-2 domain forms the PTS system translocation channel and contains the specific substrate-binding site. Cells lacking this gene are unable to grow on fructose. Growth on glucose is unaffected. PTS-type transport systems are very rare in archaea.