Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:23792132). During male gametogenesis in the mosquito gut, required for male exflagellation, possibly by regulating male gamete exit from the host erythrocytes (PubMed:29042501). Not required for asexual blood stage proliferation (PubMed:29042501). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Activated by calcium (PubMed:23792132). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (By similarity). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-232, which leads to the kinase activation (By similarity). kcat is 0.002 sec(-1) with ATP as substrate (at 30 degrees Celsius). Monomer. During the asexual blood stage, expressed in schizonts and to a lower extend in trophozoites (at protein level) (PubMed:29042501). Expressed in gametocytes during the sexual blood stage (at protein level) (PubMed:10760601, PubMed:29042501). The EF-hand domain 2 appears to lack a functional calcium binding site. The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive. The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains. Myristoylated; myristoylation may target it to different subcellular compartments. Autophosphorylated in vitro. Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.