Plays a role in the transport and release of virions form the host cytoplasm to the extracellular space. Relocalizes host NEDD4, a cytosolic E3 ligase, to cytoplasmic vesicles. Interacts with host ITCH; this interaction induces ubiquitination and probably degradation of ITCH (PubMed:29535361). Interacts with host NEDD4; this interaction increases NEDD4 ubiquitination (By similarity). Interacts with UL11 (By similarity). Late-budding domains (L domains) are short sequence motifs essential for viral particle budding. They recruit proteins of the host ESCRT machinery (Endosomal Sorting Complex Required for Transport) or ESCRT-associated proteins. UL56 contains three L domains: the PPXY motifs which are involved in the interaction with ITCH, a member of the NEDD4 family. Belongs to the herpesviridae UL56 family.