Chlorophenol O-methyltransferase that methylates chlorophenols into chloroanisoles which are thought to be responsible for cork taint of wines (PubMed:20144725, PubMed:12957890). The only single chlorophenol (CP) methylated is 2-CP; neither 3-CP nor 4-CP are effective substrates (PubMed:12957890). Within the dichlorophenols (DCPs), 2,4-DCP supports the highest rate of O-methylation, and the activity decreases in the following order: 2,3-DCP, 2,5-DCP, 2,6-DCP, and 3,4-DCP (PubMed:12957890). Within the trichlorophenol (TCP) group, the maximal activity is observed with 2,3,4-TCP, whereas there is increasingly reduced activity with 2,4,5-TCP, 2,4,6-TCP, and 2,3,6-TCP (PubMed:12957890). The only tetrachlorophenol (TeCP) that is methylated is 2,3,4,5-TeCP, since no activity can be detected with 2,3,4,6-TeCP and 2,3,5,6-TeCP (PubMed:12957890). Is also able to methylate other halogenated phenols containing fluoro or bromo substituents, whereas other hydroxylated compounds, such as hydroxylated benzoic acids, hydroxybenzaldehydes, phenol, 2-metoxyphenol, and dihydroxybenzene, were not methylated (PubMed:12957890). 2,4,6-trichlorophenol + S-adenosyl-L-methionine = 2,4,6-trichloroanisole + S-adenosyl-L-homocysteine S-adenosyl-L-homocysteine acts as a competitive inhibitor (PubMed:12957890). Also strongly inhibited by low concentrations of several metal ions, such as Cu(2+), Hg(2+), Zn(2+), and Ag(+), and to a lesser extent by p-chloromercuribenzoic acid, but it is not significantly affected by several thiols or other thiol reagents (PubMed:12957890). Optimum pH is 8.2-8.5. Optimum temperature is 28 degrees Celsius. Expression is specifically induced by several chlorophenols, especially if they contained three or more chlorine atoms in their structures, such as 2,4,6-trichlorophenol (PubMed:20144725, PubMed:12957890). Chloroanisoles such as 2,4,6-trichloroanisole (TCA) are known compounds which are usually associated with wine faults (PubMed:28842039). They belong to the family of haloanisoles which are key substances responsible for cork taint in wines (PubMed:28842039). Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. Tainted - Issue 204 of June 2018