Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (By similarity). Promotes ADAM10-mediated cleavage of CDH2 (By similarity). Negatively regulates ligand-induced Notch activity probably by regulating ADAM10 activity (By similarity). Interacts with ADAM10; the interaction influences ADAM10 substrate specificity. Belongs to the tetraspanin (TM4SF) family.