Has double-stranded DNA-stimulated ATPase activity (PubMed:12464178). Has ATP-dependent DNA helicase (5' to 3') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Represses gene activation mediated by beta-catenin (PubMed:12464178). Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). Involved in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway where it negatively regulates expression of ER stress response genes (By similarity). May act as a regulator of embryonic heart growth (PubMed:12464178). ATP + H2O = ADP + H(+) + phosphate Forms homohexameric rings (Probable). Can form a dodecamer with ruvbl1 made of two stacked hexameric rings (By similarity). Component of the chromatin-remodeling Ino80 complex (By similarity). Component of some MLL1/MLL complex (By similarity). Widely expressed in the embryo. After 60 hours post-fertilization there is increased expression in heart, liver, branchial arches, exocrine pancreas and intestine. Fishes display embryonic cardiac hyperplasia with increased cell number and size by 72 hours post-fertilization. Gut and gut-derived organs are incapable of growth and differentiation after this time. The mutation enhances ATPase activity, rendering it DNA-independent and causes aggregation of the protein into large complexes. Belongs to the RuvB family.