Splits dipeptides with a prolyl or hydroxyprolyl residue in the C-terminal position. Plays an important role in collagen metabolism because of the high level of iminoacids in collagen (By similarity). Hydrolysis of Xaa-|-Pro dipeptides. Also acts on aminoacyl-hydroxyproline analogs. No action on Pro-|-Pro. Binds 2 manganese ions per subunit. Homodimer. Belongs to the peptidase M24B family. Eukaryotic-type prolidase subfamily.