Virulence factor that interferes with host Toll-like receptor 2 (TLR2) and TLR4 signaling, resulting in the reduction of dendritic cell maturation, inhibition of pro-inflammatory cytokine secretion and impaired NF-kappa-B activation in macrophages (PubMed:18266466). Acts as a NAD(+) hydrolase (NADase) by catalyzing cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide (PubMed:29395922). In addition to ADPR, also generates a cyclization variant of cyclic ADPR (cADPR), termed v-cADPR, for which the cyclizing bond is unknown (PubMed:29395922). H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide Homodimer (PubMed:24076024). Interacts with host TIRAP (PubMed:27311859). May interact with host MYD88 (PubMed:22155231). Interaction with host MYD88 however requires confirmation as it could not be confirmed by another study (PubMed:27311859). Translocated into the host cell via the type IV secretion system (T4SS). The TIR domain mediates NAD(+) hydrolase (NADase) activity. Self-association of TIR domains is required for NADase activity.