Heterodimeric zinc metalloprotease VAP2 that induces apoptosis in endothelial cells, without triggering cell detachment. Binds 1 zinc ion per subunit. Heterodimer of VAP2A and VAP2B; non-covalently linked. Expressed by the venom gland. LD(50) is 0.1 ug/ml against vascular endothelial cells in culture. Belongs to the venom metalloproteinase (M12B) family. P-III subfamily. P-IIIc sub-subfamily.