May be part of an oligomeric complex which is likely to have a transport or channel function in the erythrocyte membrane. Restricted to tissues or cell lines expressing erythroid characters. Palmitoylated. RHD and RHCE are responsible for the Rh blood group system. The molecular basis of the Tar=Rh40 blood group antigen is a variant in position 110. Homozygous deletion of the RHD gene results in Rh-negative (dd) individuals (PubMed:1824267, PubMed:10845894). Some polymorhisms lead to weak RHD expression. This phenotype called weak D, formerly known as D(u), is observed in about 0.2% to 1% of Caucasians (PubMed:9864185). Moderately decreased RHD expression results in a phenotype called DHMi (PubMed:9864185). The disease is caused by variants affecting the gene represented in this entry. Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily. Blood group antigen gene mutation database