DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphoproliferation. Most probably causes the lymphoproliferative responses occurring in leprosy. Homodimer. The C-terminal domain binds DNA and the N-terminal domain is involved in dimerization. Both domains are essential for normal function (By similarity). Belongs to the Lsr2 family.