The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CelABD PTS system is involved in cellobiose transport. The EIIC type-3 domain forms the PTS system translocation channel and contains the specific substrate-binding site.