May play a role in intracellular immune modulation by activating NF-kappaB response and attenuating Toll-like-receptor response. (Microbial infection) Plays an essential function in adeno-associated virus (AAV) transduction across multiple serotypes except AAV5. May play a critical role in mediating the endosomal virus escape or in the AAV virions trafficking from endosomes to the nucleus. Colocalizes with TLR3, -7, -4, and -9. (Microbial infection) N- and C-terminal domains are required for AAV transduction. Belongs to the LU7TM family.