Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli. Interacts with CACTIN (via N-terminal domain); the interaction occurs in a proinflammatory-independent manner. Nuclear localization with a speckled expression pattern in some cells. Colocalizes with CACTIN in the nucleus. Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes. Arg-224 is found in the MHC 7.1 haplotype (HLA-A3,B7,DR15) population. Disease susceptibility is associated with variants affecting the gene represented in this entry. Truncated C-terminus.