ATP-driven Ca(2+) ion pump involved in the maintenance of basal intracellular Ca(2+) levels at the presynaptic terminals. Uses ATP as an energy source to transport cytosolic Ca(2+) ions across the plasma membrane to the extracellular compartment (PubMed:25014339, PubMed:9880546). May counter-transport protons, but the mechanism and the stoichiometry of this Ca(2+)/H(+) exchange remains to be established (PubMed:25014339, PubMed:9880546). ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate Interacts with PDZD11. Interacts (via N-terminus) with YWHAE. Localized at parallel fiber terminals. There is a combination of two alternative spliced domains at N-terminal site A (X and Z) and at C-terminal site C (A, B, C, D, E and F). So far the splice sites have been studied independently. Experimental confirmation may be lacking for some isoforms. Expressed predominantly in brain and skeletal muscle (PubMed:2530223). Expressed in the molecular layer of the cerebellar cortex, in particular in granule cells (at protein level) (PubMed:27035656, PubMed:17183553, PubMed:9880546). Expressed in aldosterone producing glomerulosa cells of adrenal glands (at protein level) (PubMed:27035656). Detected at low levels in various tissues including testis, stomach, small intestine, and large intestine (PubMed:2530223). Most abundant form in brain and most other tissues. Most abundant form in skeletal muscle and is also found in brain and at low levels in testis and kidney. Up-regulated upon activation of glutamate-operated calcium channels. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.