Transcription factor; part of cell wall integrity (CWI) signaling pathway composed of pkcA, the bck1-mkk2-mpka MAPK cascade and the downstream rlmA transcription regulator (PubMed:16372009). The CWI signaling pathway regulates cell wall integrity and pyomelanin formation (PubMed:19715768). CWI controls also oxidative stress response, gliotoxin production, iron adaptation and asexual development (PubMed:21883519, PubMed:32005734). Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection (PubMed:33010083). Positively regulates the phosphorylation of mpkA (PubMed:27473315). Involved in tolerance to oxidative damage and transcriptional regulation of genes related to oxidative stress adaptation (PubMed:27473315). Finally, CWI is constitutively required for A.fumigatus to cope with the temperature increase found in the mammalian lung environment, during infection (PubMed:33010083). Directly regulates the expression of regulators of conidiation, including flbB, flbC, brlA, abaA, and rasB, as well as genes involved in cell wall synthesis and remodeling (PubMed:32005734). Specifically associates with the target fumiquinazoline (fmq) cluster genes promoters at conserved motifs (5'-TAWWWWTA-3') during conidiation to supplement mature conidia with fumiquinazoline C (PubMed:33705521). Controls also the DHN-melanin production via binding the promoter of pksP (PubMed:27393422). Interacts with hsp90. Expression is induced during cell wall stress (PubMed:27473315). Also induced during asexual development (PubMed:32005734). Phosphorylation during asexual development. Exhibits an altered cell wall organization in addition to defects related to vegetative growth and tolerance to cell wall-perturbing agents (PubMed:27473315). Results in attenuated virulence in a neutropenic murine model of invasive pulmonary aspergillosis (PubMed:27473315). Leads to reduced conidiation during asexual differentiation (PubMed:32005734). Reduces conidial pigment DHN-melanin formation (PubMed:27393422). Strongly decreases the production of fumiquinazoline C (PubMed:33705521). Belongs to the MEF2 family.