May be involved in transcriptional regulation as a repressor of ESR1/ER-alpha signaling (By similarity). Plays a role during development and organogenesis as well as in the function of the adult central nervous system. Ubiquitously expressed. Predominant expression is found in the developing central nervous system with strongest signals in the forebrain, midbrain, and hindbrain areas and in the neural tube. Expression found as early as 8.5 dpc. High expression is found in the developing limb buds of embryos. Monosumoylated at Lys-598 by CBX4 and UHRF2. Sumoylation may potentiate ZNF131 inhibition of estrogen signaling. Sumoylation does not interfere with ubiquitination (By similarity). Ubiquitinated. Belongs to the krueppel C2H2-type zinc-finger protein family.