Plays important role in immediate-early gene expression through interaction with UL82. Forms nuclear bodies in host nucleus, independently of PML. In turn, UL35 nuclear bodies associate with and remodel PML bodies. Through interaction with host DCAF1, causes cells to accumulate in the G2 phase of the cell cycle by inducing a DNA damage response. Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5. Also plays a role in the inhibition of pattern recognition receptor-mediated type I interferon signaling at the level of TBK1. Promotes cytoplasmic UL82 accumulation and inhibits UL35-containing nuclear bodies formation. Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5. Interacts with UL82. Interacts with isoform UL35A. Interacts with host UBP7; this interaction significantly inhibits the ability of USP7 to form nuclear bodies. Interacts with host DCAF1 (via C-terminus). Interacts with host SNX5; this interaction allows proper gB localization during viral assembly. Interacts wth host TBK1; this interaction prevents type I interferon production. Interacts with UL82. Interacts with isoform UL35. Interacts with host UBP7; this interaction significantly inhibits the ability of USP7 to form nuclear bodies. Interacts with host SNX5; this interaction allows proper gB localization during viral assembly. Found in nuclear bodies. Belongs to the herpesviridae pp85 family.