Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. (R)-pantetheine + H2O = (R)-pantothenate + cysteamine Monomer. Widely expressed with higher expression in spleen, kidney and blood. Overexpressed in lesional psoriatic skin. By Th17/Th1 type cytokines, but not by Th2-type. Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family.