Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site. (Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process. Binds tubulin. Binds with low affinity single-stranded RNA or DNA homopolymers. Interacts with CASC3 in an RNA-dependent manner (By similarity). Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. (Microbial infection) Interacts with HERV-K rec and gag proteins. (Microbial infection) Interacts with HIV-1 GAG polyprotein. (Microbial infection) Interacts with influenza virus NS1 protein. (Microbial infection) Interacts with Ebola virus NP, VP30 and VP35. Localizes exclusively with the rough reticulum endoplasmic (RER). Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta. One of the DRDB could be involved in RER binding. The C-terminal contains the tubulin binding domain (TBD).