When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. Interacts with SHC2 upon its aggregation-induced tyrosine phosphorylation. Detected on the cell surface in resting platelets. Expressed in thymocytes, bone marrow stromal and osteogenic cells (at protein level). Strongly expressed in kidney and heart. Moderately expressed in lung, spleen, thymus, liver, brain, testis, skin and stomach. Expressed in hematopoietic stem progenitor cells. Phosphorylated on tyrosine residues by SRC. Tyrosine phosphorylation is detected upon platelet aggregation stimulated by collagen, TRAP and thrombin and platelet-platelet contacts but not after platelet activation. Tyrosine phosphorylation enhanced its association with SHC1 and SHC2 (By similarity). Phosphorylated in the intracellular domain on tyrosine residues. Belongs to the MEGF family.