Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986). Interacts with ubiquitin (PubMed:19423704). Interacts with UBXN6, VCP and YOD1; may form a complex involved in macroautophagy (PubMed:27753622, PubMed:19887378). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains. Up-regulated by tumor necrosis factor alpha (TNF-alpha) (at protein level) (PubMed:18291623). The PUL domain is composed of 6 armadillo-like repeats and mediates the interaction with VCP C-terminus. The PFU domain mediates interaction with ubiquitin. The disease is caused by variants affecting the gene represented in this entry. Belongs to the WD repeat PLAP family. Truncated N-terminus. Truncated N-terminus. Truncated C-terminus. Truncated N-terminus. Truncated N-terminus.