May be involved in the regulation of the proteolytic processing of the amyloid precursor protein (APP) possibly also implicating APOE. May form homodimers and heterodimers with TMCC2 or TMCC3 via the coiled-coil domains (PubMed:24454821). Interacts with ribosomal proteins RPL4 and RPS6 (PubMed:24454821). Interacts with APOE and proteolytic processed C-terminal fragment C99 of the amyloid precursor protein (APP C99) (PubMed:21593558). Concentrates in discrete patches along peripheral endoplasmic reticulum tubules. Belongs to the TEX28 family. Chimeric cDNA. The N-terminus part of this cDNA matches at different locus on chromosome 1.