Transcriptional activator that binds to the regulatory region of MMP3 and thereby controls stromelysin expression. It stimulates the activity of various transcriptional activators such as JUN, SP1, PAX6 and ETS1, suggesting a function as a coactivator. Homodimer (Probable). Interacts with RNF4 and JUN (By similarity). Expressed in most tissues, except in ovary and prostate. Isoform 1 is exclusively expressed in brain, heart and testis, and this form predominates in liver and kidney. Isoform 2 predominates in lung. The atypical PHD domain functions as a negative modulator of cofactor binding. The disease is caused by variants affecting the gene represented in this entry.