G-protein coupled receptor for cannabinoids (By similarity). Mediates many cannabinoid-induced effects in the central nervous system (CNS), as well as in peripheral tissue (By similarity)s. Regulates cellular respiration and energy production in response to cannabinoids (By similarity). Signaling typically involves reduction in cyclic AMP (By similarity). Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic. Expressed in neurons, especially in the olfactory bulbs, telencephalic pallium, and hypothalamus and also in the midbrain and hindbrain (in the mesencephalic tegmentum and dorsolateral rhombencephalon). Expressed also in the spinal cord. Palmitoylation at Cys-415 is important for recruitment at both plasma membrane and lipid rafts and association with G protein alpha subunits. Belongs to the G-protein coupled receptor 1 family.