Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. H2O + O-phospho-L-seryl-[protein] = L-seryl-[protein] + phosphate H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] + phosphate Binds 1 Fe(3+) ion per subunit. Binds 1 zinc ion per subunit. Interacts with sra in a complex that contains CanA-14F. Expressed in CNS and PNS. Expressed both maternally and zygotically in embryos, larvae and adults. Belongs to the PPP phosphatase family. PP-2B subfamily.