May play a role in mitochondrial mRNA editing by facilitating the association of the gRNA-binding (GRBC) complex with the RNA editing core (RECC) complex (PubMed:26769962). However, appears to be dispensable for mRNA editing per se (PubMed:26769962). Component of the REH2-associated complex (REH2C) composed of helicase REH2, associated factors H2F1 and H2F2, and mRNAs at various editing stages; the formation of the complex is RNA-independent (PubMed:26769962). Interacts with various editing complexes including the RNA editing core (RECC) complex, the gRNA-binding (GRBC) complex (also known as the MRB1 complex) and the RNA editing mediator (REMC) complex (PubMed:26769962). Expressed at the procyclic stage (at protein level). RNAi-mediated knockdown at the procyclic stage does not cause defects in RHE2 interaction with H2F1 or their association with components of the RECC and GRBC editing complexes; however, causes a slight decrease in the association of the GRBC complex with the RECC complex (PubMed:26769962). No defect in mitochondrial mRNA editing (PubMed:26769962).