Transcriptional repressor during pronephros development. Plays a role in regionalization of the pronephros; may promote formation of the distal tubule and duct over formation of the glomus and proximal tubule. Homooligomer (By similarity). Interacts with ctbp. Expressed dynamically during embryonic development; in the developing pronephros, specific areas of the brain (forebrain, midbrain and hindbrain), and in the majority of the visceral arch, and head mesenchyme derived from neural crest cells. Within the pronephros, expressed in the ventroposterior region of the pronephros anlagen from stage 20 (and is absent from the splanchnic layer that forms the glomus), then expression becomes restricted to the distal tubule and duct by the tadpole stage. In adults, expressed in various tissues including kidney, lung, testis, spleen and stomach. Expressed in embryos and adults. May be expressed in oocytes. By retinoic acid (RA) signaling. Repressed by wt1 and by notch signaling. The CTBP-binding motifs and the N-terminal group of zinc fingers are required for repressor activity in the pronephros. Although PubMed:15905132 report high expression throughout oocyte development and throughout embryogenesis, PubMed:16574097 detect no maternal expression, with zygotic expression beginning at stage 20 (end of neurulation).