Potent antibacterial peptide with anti-inflammatory properties. Inhibits both Gram-negative and Gram-positive bacteria by disrupting both the outer membrane and the cytosolic membrane of bacteria. Also downregulates the expression of pro-inflammatory mediators (cyclooxygenase-2 (PTGS2/COX2), nitric oxide-induced synthase (NOS2), IL-1 beta (IL1B), TNF-alpha (TNF)) and upregulates the level of anti-inflammatory cytokine (IL10) by inactivating mitogen-activated protein kinase signaling in a lipopolysaccharide-stimulated murine macrophage cell line. Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Belongs to the neurotoxin 19 (CSTX) family.