May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth. Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. Optimum pH is about 3.8. Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues. The disease is caused by variants affecting the gene represented in this entry. Enzymatically inactive. Enzymatically inactive. Enzymatically inactive. Enzymatically inactive. Enzymatically inactive. Belongs to the glycosyl hydrolase 56 family.