Required for axonemal dynein assembly and ciliary motility in ciliated organs, including Kupffer's vesicle, during embryogenesis. Expressed in organs bearing motile cilia, including the pronephros, otic vesicles and Kupffer's vesicle. Detected at several stages during embryogenesis, but only within organs bearing motile cilia. Defects are the cause of a phenotype related to primary ciliary dyskinesia (PCD). Embryos have curly tails, pronephric cysts and left-right asymmetry defects. Belongs to the WD repeat WDR69 family.