Inhibits TTX-sensitive and TTX-insensitive sodium currents (IC(50) is 0.6 uM and 0.95 uM respectively) on rat dorsal root ganglion (DRG) neurons (PubMed:18581053, PubMed:19409400). Inhibits muscular subtypes sodium channels Nav1.4/SCN4A and Nav1.5/SCN5A transiently transfected in to HEK293 cells (IC(50) is 5.42 uM and 0.45 uM respectively). Also blocks Kv2.1/KCNB1 potassium channels expressed in X.laevis oocytes with an IC(50) of 604 nM. Injection of the toxin in mice was immediately followed by general ataxia, lack of response to stimuli and semiparalysis (PubMed:19409400). Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Monoisotopic mass. Belongs to the neurotoxin 10 (Hwtx-1) family. 47 subfamily. Truncated N-terminus.