Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X-X-S/T-C2 of thrombospondin type I repeats (TSRs) where C1 and C2 are the first and second cysteines of the repeat, respectively (By similarity). O-fucosylates sporozoite proteins CSP and TRAP (By similarity). O-fucosylation regulates stability and intracellular trafficking of TRAP but not of CSP (PubMed:28916755). Probably by regulating protein O-fucosylation, may play a role in parasite transmission to the mosquito vector and/or infection of the vertebrate host hepatocytes; however, POFUT2 involvement in transmission/infection is controversial (PubMed:28916755, PubMed:31334132). GDP-beta-L-fucose + L-seryl-[protein] = 3-O-(alpha-L-fucosyl)-L-seryl-[protein] + GDP + H(+) GDP-beta-L-fucose + L-threonyl-[protein] = 3-O-(alpha-L-fucosyl)-L-threonyl-[protein] + GDP + H(+) Protein modification; protein glycosylation. Expressed during parasite asexual blood stages, including at the ring, trophozoite and schizont stages (at protein level). In S.stephensi mosquito vector, development into ookinete is normal; however, the number of oocysts developing at the basal lamina of the mosquito midgut is reduced resulting in 45-55% fewer sporozoites in the mosquito salivary glands (PubMed:28916755). In sporozoites, cell traversal activity, invasion of host hepatocytes and gliding motility are severely reduced (PubMed:28916755). Also, TRAP, but not CSP, protein levels are reduced and TRAP localization to the cell membrane is impaired (PubMed:28916755). Development in host erythrocytes and gametogenesis are normal (PubMed:28916755). However, another study showed that in A.gambiae mosquito vector, number of oocysts in the midgut, number of sporozoites in the salivary glands, and sporozoite gliding motility are normal (PubMed:31334132). Also invasion of host hepatocytes by sporozoites is normal (PubMed:31334132). Belongs to the glycosyltransferase 68 family. Truncated N-terminus.