Cytochrome P450 monooxygenase involved in the biosynthesis of culmorin, a tricyclic sesquiterpene diol reported to have antifungal activity and some phytotoxicity to wheat coleoptile tissue, contributing to Fusarium head blight disease (PubMed:19880637). The terpene cyclase CLM1 is responsible for the cyclization of farnesyl diphosphate into the intermediate longiborneol (PubMed:19880637). Longiborneol is then hydroxylated in a regio- and endo-stereoselective manner at position C-11 by the cytochrome P450 monooxygenase CLM2 to produce culmorin (PubMed:26673640). Additional non-specific oxygenases are also able to hydroxylate longiborneol at other sites than C-11 leading to 3-hydroxylongiborneol, 5-hydroxylongiborneol, 12-hydroxylongiborneol and 15-hydroxylongiborneol (PubMed:26673640). Moreover, another oxygenase capable of installing a C-11 exo-hydroxy group in longiborneol can also yield 11-epi-acetylculmorin (PubMed:26673640). The production of these longiborneol derivatives is dwarfed by the high abundance of culmorin, suggesting that CLM2 displays superior enzymatic activity to the unidentified, possibly promiscuous, additional oxygenases (PubMed:26673640). Mycotoxin biosynthesis. Leads to complete loss of culmorin production (PubMed:26673640). Accumulates 3-hydroxylongiborneol, 5-hydroxylongiborneol, 12-hydroxylongiborneol and 15-hydroxylongiborneol, suggesting that non-specific oxygenases are still able to hydroxylate longiborneol at other sites than C-11 (PubMed:26673640). Accumulates also 11-epi-acetylculmorin, pointing to the existence of an oxygenase capable of installing a C-11 exo-hydroxy group in longiborneol, whose activity is not apparent until CLM2 is disrupted (PubMed:26673640). Does not affect the trichothecene biosynthetic pathway since 15-acetyldeoxynivalenol (15ADON) is still produced (PubMed:26673640). Belongs to the cytochrome P450 family.