Extended spectrum beta-lactamase (ESBL) that inactivates beta-lactam antibiotics by hydrolyzing the amide group of the beta-lactam ring. Displays high levels of penicillinase and cephalosporinase activity as well as measurable activity with carbapenems, including imipenem and meropenem. Plays a primary role in the intrinsic resistance of mycobacteria to beta-lactam antibiotics. a beta-lactam + H2O = a substituted beta-amino acid Is inhibited by clavulanate. Monomer. Exported by the Tat system. The position of the signal peptide cleavage has not been experimentally proven. Belongs to the class-A beta-lactamase family.