Regulates vascular tubulogenesis in vivo. Inhibits platelet-derived growth factor (PDGF)-BB-induced smooth muscle cell migration and promotes endothelial cell adhesion to the extracellular matrix and angiogenesis. Interacts with ITGAV/ITGB3 in an RGD-dependent manner, increasing endothelial cell's motility. Endothelial cells depleted in EGFL7 by siRNAs display dramatic alterations in adhesion, morphology, and sprouting. The defects are in part due to diminished RhoA expression and impaired focal adhesion localization.