ATP + H2O = ADP + H(+) + phosphate Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP. Exhibits granular localization in the nucleus, as well as in the cytoplasm. The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX59 subfamily.