Required for left-right (L-R) asymmetry determination of organ systems in mammals. May play a role in endometrial bleeding. Mesenchymal cells of the endometrial stroma. Transiently expressed before and during menstrual bleeding. The processing of the protein may also occur at the second R-X-X-R site located at AA 132-135. Processing appears to be regulated in a cell-type specific manner. The disease is caused by variants affecting the gene represented in this entry. Belongs to the TGF-beta family. Authors have revised their sequence, but have not submitted the revised DNA sequence.