Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions. Up-regulated by a wide range of conditions, such as intracellular iron depletion, carbon source restriction, high temperature, high osmotic stress, cold stress, unfolded protein response, and high hydrostatic pressure. The promoter contains several binding sites for the stress response transcription factors MSN2, MSN4 and HSF1. Down-regulated when treated with different antifungal drugs from the azole class. Present with 8450 molecules/cell in log phase SD medium. Belongs to the RGI1 family.