Plays a role as a transcriptional activator involved in the early stage of somatic cell reprogramming. Promotes the differentiation of protein-induced pluripotent stem (PiPS) cells into endothelial cells and the formation of vascular-like tubes (in vitro). Involved in the transcription induction of vascular endothelial-cadherin (VE-cadherin) expression. Associates to the VE-cadherin gene promoter. Translocated from the cytoplasm to the nucleus in protein-induced pluripotent stem (PiPS) endothelial cells. Expressed in endothelial cell (EC) and protein-induced pluripotent stem (PiPS) endothelial cell (EC) (at protein level). Up-regulated during protein-induced pluripotent stem (PiPS) endothelial cell differention. Up-regulated by VEGFA and POU2F1 (at protein level). Probable retrogene derived from SET transcript. Belongs to the nucleosome assembly protein (NAP) family. It is uncertain whether Met-1 or Met-11 is the initiator.