Mediates transcriptional and post-transcriptional regulation of SLC5A1. Inhibits a dynamin and PKC-dependent exocytotic pathway of SLC5A1. Also involved in transcriptional regulation of SLC22A2. Exhibits glucose-dependent, short-term inhibition of SLC5A1 and SLC22A2 by inhibiting the release of vesicles from the trans-Golgi network (By similarity). Regulates the expression of SLC5A1 in a tissue-specific manner and is specifically involved in its regulation in the small intestine. Interacts with YRDC. Localizes at the inner side of the plasma membrane. Expressed in epithelial and subepithelial cells of small intestine. Mice show a specific phenotype: first, a post-transcriptional up-regulation of SLC5A1 in the small intestine, with an increased d-glucose absorption rate and capacity; second, an increased food intake that results in a visceral type of obesity.