Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors. Deficient mice show postnatal growth retardation secondary to severe structural abnormalities of the stomach, duodenum, jejunum and decreased intestinal uptake of D-glucose and levels of the intestinal D-glucose transporter Slc5a1.