PPIases accelerate the folding of proteins (By similarity). It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (PubMed:24939849). [protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0) Binds cyclosporin A (CsA). CsA mediates some of its effects via an inhibitory action on PPIase. Expressed in pollen. Not glycosylated. Causes an allergic reaction in human. Binds to IgE in 100% of 15 patients tested allergic to periwinkle C.roseus pollen. Causes release of beta-hexosaminidase from rat basophil leukemia (RBL) cells. Belongs to the cyclophilin-type PPIase family.