Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (By similarity). Interacts with ADORA2A (via its cytoplasmic C-terminal domain) (PubMed:23994616). Interacts with GNAS, GNAL, GNAQ, and GNA13 (By similarity). Interacts with MAPRE1 (By similarity). Colocalizes with ADORA2A at neuronal processes (PubMed:23994616). Colocalizes with and tracks the tips of microtubule plus ends (By similarity). Expressed in the cortical tissue (at protein level). Belongs to the GAS2 family.