Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined. Expressed in fetal liver. A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes. The disease is caused by variants affecting the gene represented in this entry. The translocation involving this gene was originally published as t(X;11)(q13;23), but BRWD3 is localized to Xq21 and not to Xq13. Truncated N-terminus.