Anti-inflammatory scavenger of eicosanoids and antithrombotic protein that inhibits platelets aggregation induced by collagen, ADP and convulxin (GPVI agonist) (PubMed:21475772, PubMed:22311975). Exhibits high affinity binding for glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) and endothelial cell alphaVbeta3 (ITGAV/ITGB3) integrins, but not for alpha-5/beta-1 or alpha-2/beta-1 (PubMed:21475772). Accordingly, it blocks endothelial cell adhesion to vitronectin (IC(50)~1 nM) and marginally to fibronectin (IC(50)~1 uM), but not to collagen (PubMed:21475772). It also inhibits fibroblast growth factor (FGF)-induced endothelial cell proliferation, and attenuates tube formation in vitro (PubMed:21475772). In addition, it dose-dependently attenuates thrombus formation to collagen under flow (PubMed:21475772). Also binds proinflammatory cysteinyl leukotrienes (leukotrienes C4 (LTC4), D4 (LTD4) and E4 (LTE4)) with submicromolar affinities (PubMed:22311975). Expressed in salivary glands. Belongs to the CRISP family.