High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. Heterodimer with NRP1. Binds PLXNB1 (By similarity). Found in certain neuronal populations of the CNS, including dorsal root ganglia, and in other non-neuronal tissues including mesenchymal tissue lining in the ribs. Increased in dorsal root ganglia in response to injury caused by dorsal rhizotomy (PubMed:28270793). Increased in dorsal root ganglia in response to sciatic transection injury (PubMed:28270793). Transiently increased in dorsal root ganglia in response to sciatic nerve crush injury, returning to comparable levels 42 days post-injury (PubMed:28270793). The tandem CUB domains mediate binding to semaphorin, while the tandem F5/8 domains are responsible for heparin and VEGF binding. Belongs to the neuropilin family.