Acyl-CoA synthetase required for both the import of long chain fatty acids (LCFAs) (C14-C18) and the activation very long chain fatty acids (VLCFAs) (C20-C26) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids (PubMed:9079682, PubMed:11330068, PubMed:9988704, PubMed:12052836, PubMed:12601005). The transport and fatty acyl-CoA synthetase activities are genetically separable and are thus independent activities (PubMed:12052836). Esterifies VLCFAs in the peroxisome matrix. The VLCFAs are actively transported into peroxisomes by a PXA1-PXA2 heterodimeric transporter in the peroxisomal membrane (PubMed:22493507). a very long-chain fatty acid + ATP + CoA = a very long-chain fatty acyl-CoA + AMP + diphosphate ATP + CoA + tetracosanoate = AMP + diphosphate + tetracosanoyl-CoA Interacts with fatty acyl-CoA synthetases FAA1 and FAA4. The FACS motif is required for catalytic activity and substrate specificity. Present with 16900 molecules/cell in log phase SD medium. Belongs to the ATP-dependent AMP-binding enzyme family.