Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping (By similarity). Required for cortical actin clearance prior to oocyte exocytosis (By similarity). Promotes cell motility in conjunction with S100A4 (By similarity). During cell spreading, plays an important role in cytoskeleton reorganization, focal contact formation (in the margins but not the central part of spreading cells), and lamellipodial retraction; this function is mechanically antagonized by MYH10 (By similarity). Myosin is a hexameric protein that consists of 2 heavy chain subunits (MHC), 2 alkali light chain subunits (MLC) and 2 regulatory light chain subunits (MLC-2). Interacts with RASIP1 (By similarity). Interacts with DDR1 (By similarity). Interacts with PDLIM2 (PubMed:15505042). Interacts with SVIL (By similarity). Interacts with HTRA3 (By similarity). Interacts with Myo7a (By similarity). Interacts with CFAP95 (By similarity). Interacts with LIMCH1; independently of the integration of MYH9 into the myosin complex (By similarity). Interacts with RAB3A (By similarity). Interacts with ZBED4 (By similarity). Interacts with S100A4; this interaction increases cell motility (By similarity). Colocalizes with actin filaments at lamellipodia margins and at the leading edge of migrating cells (By similarity). In retinal pigment epithelial cells, predominantly localized to stress fiber-like structures with some localization to cytoplasmic puncta (By similarity). The rodlike tail sequence is highly repetitive, showing cycles of a 28-residue repeat pattern composed of 4 heptapeptides, characteristic for alpha-helical coiled coils. ISGylated. Ubiquitination. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. Reported to interact with SLC6A4 in its sialylated form. However, this publication was retracted due to image duplication in the figures.