Functions in the intrinsic apoptotic signaling pathway and may have an interferon-induced antiviral activity. Homooligomer (PubMed:21151029). Interacts with BAK1 (PubMed:21151029). Interacts with BAX (PubMed:21151029). Interacts with adenine nucleotide translocase (PubMed:21151029). Up-regulated by type-I interferon (PubMed:21151029). Up-regulated by poly(I:C) (PubMed:21151029). Belongs to the IFI6/IFI27 family.