RNA-binding protein which regulates transcription, splicing and RNA-editing (PubMed:25391662). Limits the accumulation of double-stranded RNA by maintaining the abundance of the mature RNA transcripts that are formed from double-stranded precursor RNAs (PubMed:25391662). Stress response protein that acts downstream of daf-16 in the insulin/IGF pathway to regulate longevity and the cellular stress response to osmotic, oxidative, proteotoxic and endoplasmic reticulum stress (PubMed:22232551, PubMed:22792076). Involved in the regulation of physiological processes including aging, fertility, growth and locomotion (PubMed:22232551, PubMed:29760282). Plays a role in maintaining localization of chromobox protein homolog hpl-2 to gene bodies, perhaps acting via binding to nascent RNA transcripts (PubMed:29760282). Interacts with chromobox protein homolog hpl-2; interaction may maintain localization of hpl-2 to gene bodies. Shuttles from the nucleus to the cytoplasm under stress conditions. Widely expressed in a range of tissues including body wall muscles, pharynx and neurons of the midbody in adults and larvae (PubMed:22232551, PubMed:22792076). By hyperosmotic, oxidative and endoplasmic reticulum stress (at protein level). Increased lifespan, slower growth rate, reduced egg-laying and reduced fertility (PubMed:22232551, PubMed:22792076). Defective locomotion and chemotaxis (PubMed:22232551, PubMed:25391662). Increased sensitivity to osmotic and oxidative stress (PubMed:22792076). Increased intronic A-to-I RNA editing and splicing abnormalities, which may contribute to the increased accumulation of double-stranded RNA observed in the nucleus of multiple tissues including gut, muscle and the anterior head region (PubMed:25391662).