Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity). Interacts (via C-terminal cytoplasmic tail) with PI4KA. Localizes mainly at the plasma membrane; only a minor fraction localizes on intracellular structures. Belongs to the DRAM/TMEM150 family.