Glycerophosphocholine acyltransferase (GPCAT) that utilizes acyl-CoA to acylate glycero-3-phosphocholine (GPC), forming lysophosphatidylcholine (LPC) (PubMed:18430972, PubMed:27758859). Shows broad acyl specificities with a preference for 16:0-CoA, polyunsaturated acyl-CoA, and the hydroxylated ricinoleoyl-CoA (PubMed:18430972, PubMed:27758859). Catalyzes also the acylation of glycero-3-phosphoethanolamine (GPE) with acyl-CoA (PubMed:27758859). In addition to acyl-CoA, GPCAT efficiently utilizes LPC and lysophosphatidylethanolamine (LPE) as acyl donors in the acylation of GPC (PubMed:27758859). Contributes to the maintenance of phosphatidylcholine (PC) homeostasis and might also have specific functions in acyl editing of PC, such as transferring acyl groups modified at the sn-2 position of PC to the sn-1 (PubMed:27758859). Involved in postsynthetic PC remodeling that produces more saturated PC species (PubMed:30514764). an acyl-CoA + sn-glycerol 3-phosphocholine = a 1-acyl-sn-glycero-3-phosphocholine + CoA an acyl-CoA + sn-glycero-3-phosphoethanolamine = a monoacyl-sn-glycero-3-phosphoethanolamine + CoA (9Z)-octadecenoyl-CoA + sn-glycero-3-phosphoethanolamine = (9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + CoA hexadecanoyl-CoA + sn-glycerol 3-phosphocholine = CoA + hexadecanoyl-sn-glycero-3-phosphocholine (9Z,12Z)-octadecadienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine + CoA (12R)-hydroxy-(9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (12R-hydroxy-9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA (9Z,12Z,15Z)-octadecatrienoyl-CoA + sn-glycerol 3-phosphocholine = (9Z,12Z,15Z-octadecatrienoyl)-sn-glycero-3-phosphocholine + CoA (9Z)-octadecenoyl-CoA + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + CoA 1-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine + sn-glycerol 3-phosphocholine = (9Z-octadecenoyl)-sn-glycero-3-phosphocholine + sn-glycero-3-phosphoethanolamine The GPCAT activity is sensitive to N-ethylmaleimide, phenanthroline, and divalent cations including Ca(2+), Mg(2+), Mn(2+) and Zn(2+) (PubMed:18430972). The activity is also inhibited by glycerol-3-phosphate (G3P) (PubMed:27758859). Optimum pH is 6.5-8.5. Decreases the levels of monounsaturated PC species and increased those of diunsaturated PC species. Does not significantly affect phosphatidylethanolamine, phosphatidylinositol, and phosphatidylserine profiles. Belongs to the GPC1 family.