Catalyzes the production of acetyl-CoA. Provides the acetyl-CoA source for histone acetylation in the nucleus. 'Aerobic' isozyme of acetyl-coenzyme A synthetase, which supports growth on nonfermentable carbon sources such as glycerol and ethanol. May be required for assimilation of ethanol and acetate. acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate By acetate, acetaldehyde and ethanol. Subject to glucose catabolite repression. Inactivated and degraded after addition of glucose (at protein level). The FACS motif is required for catalytic activity and substrate specificity. Present with 2890 molecules/cell in log phase SD medium. Belongs to the ATP-dependent AMP-binding enzyme family. It is uncertain whether Met-1 or Met-25 is the initiator.