Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol (PubMed:19265156, PubMed:24563254). Not recruited to virulent type I T. gondii PV membrane (PubMed:19265156). May confer an antiviral state for vesicular stomatitis virus (PubMed:9725230). GTP + H2O = GDP + H(+) + phosphate In astrocytes stimulated with IFNG or TNF, diffuse cytoplasmic localization decreases and the protein partially relocalizes to the endoplasmic reticulum and Golgi apparatus (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). Expressed in thymus and lymph nodes, predominantly T-cells. Not expressed by immature CD4(+) CD8(+) thymocytes (at protein level) (PubMed:7836757). Expressed in IFNG-stimulated macrophages (PubMed:7884320). Expressed at low levels in unstimulated astrocytes (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene. In macrophages, up-regulated by IFNG, but not by IL2, IL4, IL10, nor TNF (PubMed:7884320). Up-regulated by IFNG in lymph node cells and thymocytes and other cell types (PubMed:7836757, PubMed:9725230, PubMed:24563254). In astrocytes, up-regulated by TNF and IFNG; when both cytokines are combined, the effect is synergistic (PubMed:19285957). Due to sequence similarity with Tgtp2, it is impossible to assign unambiguously experimental data published in the literature to Tgtp1 or Tgtp2 gene (Probable). Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. The gene Tgtp1 belongs to a large family of eutherian IFNG-inducible GTPases, called immunity-related p47 GTPases, which comprises a variable amount of paralogs depending upon the species studied. In C57BL/6J mice, there is over 20 genes, whereas humans have only one ortholog. Tgtp1 closest paralog is Tgtp2. Both genes encode identical proteins. At the nucleotide sequence level, their CDSs differ at only 4 positions. Consequently it is almost impossible to assign unambiguously to one gene or the other experimental data published in the literature.