May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. Protein modification; protein ubiquitination. Interacts with DDB1, CUL4A and CUL4B. According to PubMed:19026396, it is a nucleolar protein, while sequence analysis programs clearly predict 2 transmembrane regions. Ubiquitously expressed. The disease is caused by variants affecting the gene represented in this entry.