DNA binding protein that function as transcriptional activator. Is essential for normal postnatal growth and nursing. Is an essential factor for neuronal neuropeptide Y and agouti-related peptide function and locomotory behavior in the control of energy balance. Expressed in brain. In brain, it is restricted to a few specific developing brain structures such as pineal gland, telencephalic septum, hypothalamic pre-mammillary body and arcuate nucleus. Expressed in early embryonic stages of epiphysis development from 9.5 dpc onwards. Belongs to the distal-less homeobox family. Of fidgets and food - Issue 85 of August 2007