Iota-conotoxins bind to voltage-gated sodium channels and act as agonists by shifting the voltage-dependence of activation to more hyperpolarized levels. This toxin enhances tetrodotoxin-sensitive sodium current in rat dorsal root ganglion neurons. Expressed by the venom duct. The cysteine framework is III (CC-C-C-CC). Classified in the M-1 branch, since 1 residue stands between the fourth and the fifth cysteine residues. Belongs to the conotoxin M superfamily.