Catalyzes the hydrolysis of acyl-CoAs into free fatty acids and coenzyme A (CoASH), regulating their respective intracellular levels (PubMed:16951743). Preferentially hydrolyzes acetyl-CoA (PubMed:16951743). acetyl-CoA + H2O = acetate + CoA + H(+) butanoyl-CoA + H2O = butanoate + CoA + H(+) H2O + hexanoyl-CoA = CoA + H(+) + hexanoate Inhibited by ADP. Active in the presence of ATP (PubMed:16951743). Cold labile, it dissociates into inactive monomers at low temperature (By similarity). kcat is 7000 sec(-1) for the hydrolysis of acetyl-CoA. Lipid metabolism; fatty acid metabolism. Homodimer or homotetramer.