Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. H2O + N(7)-methyl-GMP = N(7)-methylguanosine + phosphate a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate Expressed at low levels until E13 and the expression rises transiently between E13 and E16. By norepinephrine/NE and adenosine which are released by the embryo under hypoxic conditions. By stimulation of beta-adrenergic/adenosine receptors in definitive red blood cells (RBC). Belongs to the pyrimidine 5'-nucleotidase family.