Involved in brain development probably by regulating asymmetric division of neuroblasts (PubMed:31735666, PubMed:30550790, PubMed:25259927). Regulates neuroblast asymmetric cell division by controlling asymmetric protein localization of Mira, Baz, Par-6 and aPKC, and spindle alignment (PubMed:31735666). Also, regulates the localization of kinase Ball during mitosis, specifically maintaining Ball in the nucleus during interphase (PubMed:31735666). Required for proper ER and nuclear envelope morphology in neuroblasts (PubMed:31735666). In neuroblasts, recruited to the nuclear envelope at the initiation of mitosis and remains associated with it until the beginning of cytokinesis. Expressed in embryo, wing disk and eye disk. Broadly expressed in 3rd instar larval brain, including neuroblasts, ganglion mother cells, and neurons. Animals die as third instar larvae, are smaller than wild-type and show very severely reduced brain volume (PubMed:31735666). Complete disruption of brain morphology, especially the optic lobe, in 3rd instar larvae (PubMed:31735666). Belongs to the ANKLE2 family.