Receptor for the LURY-1-1 and LURY-1-2 peptides which control food-related processes including feeding, lifespan, egg-laying and roaming behavior (PubMed:28847365). Receptor for flp-7 which stimulates serotonin-induced fat loss (PubMed:28128367). Serotonin induces secretion of flp-7 from neurons and binding to npr-22 which leads to induction of the atgp-1 lipase and subsequent fat loss (PubMed:28128367). Acts in vitro as a receptor for the flp-7 FMRFamide-like neuropeptides TPMQRSSMVRF-amide, SPMQRSSMVRF-amide, SPMERSAMVRF-amide and SPMDRSKMVRF-amide (PubMed:16377032). Also acts in vitro as a receptor for a number of other FMRFamide-like neuropeptides including the flp-1 neuropeptide PNFMRY-amide, the flp-9 neuropeptide KPSFVRF-amide, the flp-11 neuropeptides AMRNALVRF-amide, ASGGMRNALVRF-amide and NGAPQPFVRF-amide, the flp-13 neuropeptides AADGAPLIRF-amide, ASPSAPLIRF-amide, SPSAVPLIRF-amide, SAAAPLIRF-amide and ASSAPLIRF-amide, and the flp-22 neuropeptide SPSAKWMRF-amide (PubMed:16377032). The SPMERSAMVRF-amide neuropeptide from flp-7 acts as the strongest in vitro activator of npr-22 (PubMed:16377032). Expressed in many cells, mainly in the head region, with expression detected in the head muscles, I2 neurons, MC neurons, RIH neuron, AIA neurons, AUA neurons, ASK neurons, ASI neurons, a few B-type motorneurons in the posterior ventral nerve cord, pharyngeal muscles, body wall muscles, the intestine and a few classes of unidentified cells anterior to the nerve ring (PubMed:28847365). Expression in the MC neurons is important to mediate suppression of feeding while expression in the RIH neuron is important for the facilitation of egg-laying (PubMed:28847365). No expression detected in other tissues including hypodermis (PubMed:28128367). Eggs are retained in the body as normal during starvation but the number of eggs laid during the initial refeeding period is reduced and satiety-induced suppression of pharyngeal pumping is slower than wild-type (PubMed:28847365). Suppression of serotonin-induced body fat loss (PubMed:28128367). Belongs to the G-protein coupled receptor 1 family.