S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 2 (EFT1/EFT2) at 'Lys-613' and methylates elongation factor 3A (YEF3). Increases sensitivity to antibiotics that target translation and decreases translational fidelity. Present with 217 molecules/cell in log phase SD medium. Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family.