Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Translocates to the cell membrane following binding to PtdIns(4,5)P2. Expressed in the ectoderm at early gastrula stages. During neurulation, expressed in the dorsal neuroectoderm, with the strongest signal detectable in the anterior neural plate. In tadpole stages, present most prominently in the brain, eye, otic vesicle, and cranial ganglia. From stage 30 onward, expression is observed in the forebrain, midbrain, and hindbrain but is excluded from the boundaries between these domains. Belongs to the Amer family. Extended N-terminus.