Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate. Homooligomer (tetramer or pentamer) (PubMed:26200502). May interact with PPP2CB and PPP2R1B (By similarity). Predominantly expressed in the basolateral membrane of the retinal pigment epithelium. Phosphorylated by PP2A. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Belongs to the bestrophin family. Retina International's Scientific Newsletter