Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:8389765, PubMed:9195912, PubMed:19350606). May have a role in muscle signal transduction (PubMed:9195912). 3',5'-cyclic AMP + H2O = AMP + H(+) Binds 2 divalent metal cations per subunit (PubMed:19350606). Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (PubMed:19350606). Insensitive to all selective PDE inhibitors. Purine metabolism; 3',5'-cyclic AMP degradation; AMP from 3',5'-cyclic AMP: step 1/1. Interacts with CBFA2T3. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions. PDE7A2 (50 kDa) is located to particulate cellular fractions. Found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart (PubMed:9195912). It is expressed as well in two T-cell lines (PubMed:9195912). Found abundantly in skeletal muscle and at low levels in heart. Developmentally regulated (PubMed:9195912). PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development (PubMed:9195912). It persists strongly only in adult skeletal muscle (PubMed:9195912). Developmentally regulated (PubMed:9195912). PDE7A1 and PDE7A2 are found in several fetal tissues, expression is reduced throughout development (PubMed:9195912). It persists strongly only in adult skeletal muscle (PubMed:9195912). Composed of a C-terminal catalytic domain containing two putative divalent metal sites and an N-terminal regulatory domain. Belongs to the cyclic nucleotide phosphodiesterase family. PDE7 subfamily.