Toxin that blocks vertebrate P/Q-type (Cav2.1/CACNA1A) and R-type (Cav2.3/CACNA1E) voltage-gated calcium channels. Also inhibits sodium channels (Nav) in bovine chromaffin cells by delaying sodium channel inactivation. Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. Belongs to the neurotoxin 10 (Hwtx-1) family. 56 (SNX-482) subfamily.