Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. Can form homooligomers (monomers, dimers, trimers and tetramers) and heterooligomers with matrilin-1 (By similarity). Interacts with COMP. Component of a complex containing at least CRELD2, MANF, MATN3 and PDIA4 (By similarity). Expressed only in cartilaginous tissues, such as vertebrae, ribs and shoulders. The disease is caused by variants affecting the gene represented in this entry. The disease is caused by variants affecting the gene represented in this entry. Disease susceptibility is associated with variants affecting the gene represented in this entry.