RNA-binding protein that binds to misfolded non-coding RNAs, pre-5S rRNA, and several small cytoplasmic RNA molecules known as Y RNAs (PubMed:18056422, PubMed:26382853). Binds to endogenous Alu retroelements which are induced by type I interferon and stimulate porinflammatory cytokine secretion (PubMed:26382853). Regulates the expression of Alu retroelements as well as inflammatory genes (PubMed:26382853). May play roles in cilia formation and/or maintenance (By similarity). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs (PubMed:17289661). Found in a complex with PUF60 and Y5 RNA (PubMed:10668799). Interacts with RAB11FIP5 (PubMed:10545525). Localized in cytoplasmic mRNP granules containing untranslated mRNAs. The horseshoe-shaped TROVE domain is built with 7 helical HEAT-like repeats, and is closed by the VWFA-like domain giving rise to a ring-shaped monomer. Single-stranded RNA is bound in the positively charged central cavity (By similarity). The MIDAS-like motif in the VWFA-like domain binds divalent metal cations. Antibodies against normal cellular SSA2 protein are found in sera from patients with systemic lupus erythematosus (SLE). Belongs to the Ro 60 kDa family.