Catalyzes the dehalogenation of halotyrosines such as 3-iodo-L-tyrosine and 3,5-diiodo-L-tyrosine (PubMed:24153409, PubMed:28157283). Likely to also catalyze the dehalogenation of other halotyrosines such as 3-bromo-L-tyrosine, 3-chloro-L-tyrosine and 3-iodo-L-tyrosine (By similarity). Activity towards 3-iodo-L-tyrosine is much stronger than activity towards 3,5-diiodo-L-tyrosine and 2-iodophenol (PubMed:28157283, PubMed:24153409). 2 iodide + L-tyrosine + 2 NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + 2 NADPH iodide + L-tyrosine + NADP(+) = 3-iodo-L-tyrosine + NADPH 3-iodo-L-tyrosine + iodide + NADP(+) = 3,5-diiodo-L-tyrosine + H(+) + NADPH chloride + L-tyrosine + NADP(+) = 3-chloro-L-tyrosine + NADPH bromide + L-tyrosine + NADP(+) = 3-bromo-L-tyrosine + NADPH kcat 0.09 sec(-1) for the deiodination of 3,5-diiodo-L-tyrosine (PubMed:24153409). kcat is 0.27 sec(-1) for the dehalogenation of 3-iodo-L-tyrosine (at pH 7.4 and 25 degrees Celsius) (PubMed:28157283). kcat is 0.0029 sec(-1) for the dehalogenation of 2-iodophenol (at pH 7.4 and 25 degrees Celsius) (PubMed:28157283). Homodimer. Belongs to the nitroreductase family.