Pleiotropic ABC efflux transporter that shows a strong substrate specificity for the azole class of drugs such as lotrimazole (CLT), fluconazole (FLC), itraconazole (ITC), ketoconazole (KTC), posaconazole (POS), econazole (ECON), metconazole (MET), miconazole (MCZ), prochloraz (PCLZ), and tebuconazole (TEBZ). ATP + fluconazole(in) + H2O = ADP + fluconazole(out) + H(+) + phosphate ATP + H2O + itraconazole(in) = ADP + H(+) + itraconazole(out) + phosphate The efflux inhibitor FK506 impairs the transport activity. Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.