Dual-function peptide with antimicrobial and potassium channel-blocking activities (PubMed:26817841). Shows inhibitory activity against Gram-positive bacteria such as S.aureus, B.subtilis, and M.luteus as well as methicillin-resistant S.aureus (MIC=0.1-20 uM) (PubMed:26817841). Does not act on bacteria by disrupting membranes (PubMed:26817841). Also moderately inhibits Kv1.1/KCNA1 (25.2% inhibition at 1 uM), Kv1.2/KCNA2 (30.5% inhibition at 1 uM), and Kv1.3/KCNA3 potassium channels (IC(50)=510.2 nM, 61% inhibition at 1 uM) (PubMed:26817841). Inhibits potassium channels by interacting with the pore region (PubMed:26817841). Does not show hemolytic activity (PubMed:27128943). In vitro, dose-dependently decreases the production of Hepatitis B virus (HBV) DNA and HBV viral proteins in both culture medium and cell lysate (PubMed:27128943). Has the structural arrangement of an alpha-helix connected to a beta-sheet by disulfide bonds (CSalpha/beta). Has no inhibitory activity against Gram-negative bacteria (PubMed:26817841). Shows very weak inhibition of the potassium currents mediated by the Kv11.1/KCNH2/ERG1 (11.6%), KCa3.1/KCNN4/IK/SK4 (3.9%), KCa2.3/KCNN3/SK3 (7%), Kv7/KCNQ (5.9%), when tested at 1 uM (PubMed:26817841). Belongs to the invertebrate defensin family. Type 2 subfamily.