Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation. Interacts with MRTFA and SRF. The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity. O-glycosylated. A chromosomal aberration involving ZFTA is found in 3 chondroid lipomas. Translocation t(11;16)(q13;p13) with ZFTA produces a ZFTA-MRTFB fusion protein (PubMed:20607705).