Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via an indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth. In contrast to other resistance proteins, it works independently of ESD1 and NSD1 proteins and does not require the accumulation of salicylic acid, suggesting the existence of an independent signaling pathway. The specificity to avirulence proteins differs in the different cultivars. The LRR repeats probably act as specificity determinant of pathogen recognition. In cv. Nd-1, it confers resistance to Mask-9, Aswa1, Edco1, Emco5 and Goco5 loci from Hyaloperonospora parasitica. In cv. Columbia, it confers resistance to Wela3 locus from Hyaloperonospora parasitica. In cv. RLD, it confers resistance to all of these loci. Belongs to the disease resistance NB-LRR family. RPP13 subfamily. Functional and comparative genomics of disease resistance gene homologs