Transcription factor which modulates genes involved in lipid metabolism and the phase I detoxification pathway, including cytochrome P450 oxidases (PubMed:18680432, PubMed:24805825, PubMed:31346165). Required for diet restriction- and mitochondrial dysfunction-mediated lifespan extension, perhaps acting in a ubiquitination-dependent manner (PubMed:24805825, PubMed:31346165). Involved in the response to oxidative stress (PubMed:31346165). Plays a role in cell death (PubMed:18680432). Interacts with E3 ubiquitin-protein ligase wwp-1 (via WW domains). Localized to nucleus at the larval L4 stage, becoming cytoplasmic during early adulthood. Translocation to the nucleus dependent, in some circumstances, on oxidative stress. Expressed in intestine, hypodermis and a few neurons. Expressed in all developmental stages, increasing gradually from embryo to larval L4 stage, decreasing and stabilizing in adult stage (PubMed:18680432). Expressed in intestine in all larval and adult stages, and in a few neuronal and hypodermal cells (PubMed:18680432). Induced by treatment with high levels of paraquat, a chemical causing production of reactive oxygen species (ROS), but not by other exogenous stressors, such as heat shock or osmotic stress. Ubiquitinated; probably preferentially monoubiquitinated by wwp-1. RNAi-mediated knockown leads to increased cell death, perhaps by apoptosis, in the germline and uterus of hermaphrodites (PubMed:18680432). Lipid contents in the intestine increase (PubMed:18680432). RNAi-mediated knockdown causes reduced ability of dietary restriction to extend lifespan (PubMed:24805825). Abolishes lifespan extension completely on an eat-2 mutant background, independent of whether knockdown is ubiquitous, or targeted only to the intestine (PubMed:24805825). Abolishes lifespan extension on either isp-1;ctb-1 double mutant, or isp-1, gas-1 or mev-1 single mutant backgrounds; knockdown is most effective when applied in early adulthood, rather than during early development (PubMed:31346165). Further decreases the lower movement rates of isp-1;ctb-1 double mutants (PubMed:31346165). Belongs to the krueppel C2H2-type zinc-finger protein family.