A dedicated protease for gasdermin bGSDM; cleaves the bGSDM precursor, releasing the pore-forming moiety, which integrates into the membrane and triggers cell death (PubMed:35025633). Probably involved in defense against bacteriophages (Probable). Expression of bGSDM and this neighboring protease is highly toxic in E.coli. Cells expressing the gene pair stop dividing and lose membrane integrity. Both proteins are required to kill E.coli. The bGSDM recognition site is larger than the 8 residues surrounding the cleavage site; replacement of the endogenous recognition site by the Runella site (NRVLGENM) in a number of other bGSDMs is not sufficient for them to be cleaved (PubMed:35025633). Optimum pH is 8.4 to 10.2.