May play an important role in endothelial cell activation. May act as a nuclear transcription factor that negatively regulates the expression of cardiac genes (By similarity). Interacts with TTN/titin and YBX1. Expressed in heart. In postnatal neonatal heart, it is expressed in an asymmetrical way; left ventricle favored towards right ventricle. Whether or not this could be correlated with a hypertrophic heart is still a matter of debate. Levels increase gradually from newborn to adult. Down-regulated by doxorubicin (adriamycin), in vitro.