Potential catalytic subunit of the gamma-secretase complex during spermatogenesis, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors (lin-12 or glp-1) (Probable). Involved in spermatid formation during meiosis II (PubMed:9819355, PubMed:29879108). May be required for proper localization of macromolecules that are subject to asymmetric partitioning during spermatogenesis (PubMed:9819355). Homodimer. Potential component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2 (Probable). Predominantly located in the endoplasmic reticulum and in the cis-Golgi. Expressed during L4 stage, during spermatogenesis, when hermaphrodites produces sperm. The PAL motif is required for normal active site conformation. Belongs to the peptidase A22A family.