Alpha-ketoglutarate-dependent sulfate ester dioxygenase, which oxidizes medium-chain alkyl-sulfate esters (PubMed:23762287). Shows preference for 2-ethylhexyl sulfate (2-EHS) in vitro, leading to the formation of succinate and 2-ethylhexanal (PubMed:23762287, PubMed:25427196). Has likely a role in sulfate scavenging in vivo (PubMed:23762287). Also causes the inactivation of the 2-carboxyquinoxaline Ty38c (an antitubercular compound that inhibits DprE1) via oxidative decarboxylation, using Ty38c instead of alpha-ketoglutarate as a substrate. Is thus responsible for primary resistance of M.tuberculosis to Ty38c in vitro. Overexpression of Rv3406 causes resistance to Ty38c. 2-ethylhexyl sulfate + 2-oxoglutarate + O2 = 2-ethylhexanal + CO2 + H(+) + succinate + sulfate kcat is 21.8 min(-1) with alpha-ketoglutarate and 2-EHS as substrates (at pH 7 and 25 degrees Celsius). kcat is 1.54 min(-1) for the oxidative decarboxylation of Ty38c (at pH 7 and 25 degrees Celsius). Repressed by the transcriptional repressor Rv3405c. Cells lacking this gene do not replicate in minimal media with 2-ethyl hexyl sulfate as the sole sulfur source, in contrast to wild-type. Was identified as a high-confidence drug target. Belongs to the TfdA dioxygenase family.