Regulates the expression of the Rv1217c-Rv1218c multidrug efflux system and its own expression. Acts by binding to promoter regions of Rv1219c and upstream of the Rv1218c gene (PubMed:24424575). Important for survival in prolonged stationary phase and during macrophage infection (PubMed:24590482). May be used to eliminate non-growing mycobacteria (PubMed:25012658). Interaction with long chain acyl-CoA derivatives (oleoyl-CoA and, to lesser extent, stearoyl-CoA) prevents binding to DNA, leading to the expression of the target genes. Long chain acyl-CoA derivatives may serve as biological indicators of the bacterial metabolic state. Homodimer (PubMed:24424575, PubMed:25012658). Interacts with long chain acyl-CoA derivatives (PubMed:25012658). Interacts with several drugs such rhodamine 6G, ethidium and safranin O (PubMed:24424575). Expression is autoregulated. Contains an N-terminal DNA-binding domain and a C-terminal ligand-binding domain, which can accommodate a variety of structurally unrelated antimicrobial agents. The C-terminal domain is also involved in dimerization. Knockout mutant is impaired in long-term survival at stationary phase and does not persist during macrophage infection.