Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. Methylated by PrmC. Methylation increases the termination efficiency of RF2 (By similarity). The gene for this protein contains a UGA in-frame termination codon after Leu-25; a naturally occurring frameshift enables complete translation of RF-2. This provides a mechanism for the protein to regulate its own production. Belongs to the prokaryotic/mitochondrial release factor family.