Probably involved in signal transduction, in the nervous system, via increasing cell surface localization of GRM5 and positively regulating its signaling. Required for the spatial learning process. Acts as a negative regulator of Ca(2+)-calmodulin-dependent protein kinase 2 (CaMK2) phosphorylation. May play a role in modulating melanin-concentrating hormone-mediated functions via its interaction with MCHR1 that interferes with G protein-coupled signal transduction. May be involved in bone metabolism. May also be involved in neurite outgrowth (By similarity). Interacts with MCHR1 (By similarity). Interacts with SEMA4C. Interacts with DIAPH1 (via FH3 domain) (By similarity). Interacts with GRM5. Localizes to somatic regions of neurons. Localization to endosome membrane requires palmitoylation. Palmitoylated. Palmitoylation by ZDHHC1, ZDHHC3 and ZDHHC11 regulates the association of NCDN with endosome membranes. May also be palmitoylated by ZDHHC7. Belongs to the neurochondrin family.