Secreted effector that is critical to pathogenesis by suppressing plant immune responsess (PubMed:23536880, PubMed:26011314). Promotes Phytophthora infection by suppressing the H(2)O(2) accumulation and callose deposition (PubMed:26011314). May induce cell death by regulating expression of cell death-related genes (PubMed:26011314). The nuclear localization is required for both of its cell death-inducing activity and virulent function. Expression is up-regulated at the early stages of infection. The CRN proteins have modular architectures that include a signal peptide, a conserved N-terminus, and highly diverse C-terminal domains. The conserved CRN N-terminus harbors a distinct LXLFLAK motif, which is followed by the conserved DWL domain. A highly conserved HVLVXXP motif marks the end of the CRN N-terminal domains and forms a junction where diverse C-terminal domains are fused. The conserved CRN N-terminus mediates the translocation into the plant host cells. Leads to the loss of abilities to suppress pathogen-associated molecular patterns (PAMPS)-triggered immunity (PTI) in host cells. Belongs to the Crinkler effector family.