ATP + H2O = ADP + H(+) + phosphate Interacts (via HIT-type zinc finger) with the RUVBL1/RUVBL2 complex in the presence of ADP. Exhibits granular localization in the nucleus, as well as in the cytoplasm. AT 11.5 dpc, expressed in the developing snout region, eye and limb buds. At 13.5 dpc, highly enriched in the lips, palatal shelves (secondary palate), and developing limb buds. The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. Belongs to the DEAD box helicase family. DDX59 subfamily.