May be involved in the interferon-induced negative regulation of the transcriptional activity of NR4A1, NR4A2 and NR4A3 through the enhancement of XPO1-mediated nuclear export of these nuclear receptors (PubMed:22427340). Through the regulation of NR4A1 transcriptional activity, may play a role in the vascular response to injury (PubMed:22427340). Homodimer (By similarity). Interacts with SKP2 (By similarity). Interacts with NR4A1 (By similarity). May interact with BCL2 (By similarity). Up-regulated by interferon (PubMed:22427340). Up-regulated by vascular tissues injury (PubMed:22427340). Homozygous knockout mice exhibit no obvious phenotype, having normal growth rates, survival, fertility and litter sizes (PubMed:22427340). No organ pathology is detected (PubMed:22427340). However, they display decreased restenosis, the narrowing of blood vessels, upon vascular injury (PubMed:22427340). Belongs to the IFI6/IFI27 family.