Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. Can also hydrolyze CTP and the modified nucleotides pseudo-UTP, 5-methyl-CTP (m(5)CTP) and 5-methyl-UTP (m(5)UTP) (PubMed:24210219). May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids (PubMed:24210219). dTTP + H2O = diphosphate + dTMP + H(+) H2O + UTP = diphosphate + H(+) + UMP CTP + H2O = CMP + diphosphate + H(+) H2O + psi-UTP = diphosphate + H(+) + psi-UMP 5-methyl-CTP + H2O = 5-methyl-CMP + diphosphate + H(+) H2O + TTP = 5-methyl-UMP + diphosphate + H(+) kcat is 11.6 sec(-1) with dTTP as substrate. kcat is 4.9 sec(-1) with UTP as substrate. kcat is 7.1 sec(-1) with CTP as substrate. kcat is 2.4 sec(-1) with m(5)UTP as substrate. kcat is 8.5 sec(-1) with m(5)CTP as substrate. kcat is 7.2 sec(-1) with pseudo-UTP as substrate. Homodimer. Not essential for cell division. Overexpression results in extensive filamentation caused by a disruption and subsequent inhibition of the septation process. Belongs to the Maf family. YhdE subfamily.