Component of the DNA topoisomerase VI involved in chromatin organization and progression of endoreduplication cycles. Relaxes both positive and negative superturns and exhibits a strong decatenase activity (By similarity). May be involved in cell proliferation and stress tolerance. ATP-dependent breakage, passage and rejoining of double-stranded DNA. Homodimer. Heterotetramer of two TOP6A and two TOP6B subunits (By similarity). Interacts with TOP6B. Highly expressed in flowers before pollination. Expressed in roots and shoots. By auxin, abscisic acid (ABA) and benzylaminopurine. Belongs to the TOP6A family.