Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 may be important for eye retinal development and for myogenesis. Up-regulated in mammary gland tumors. The FZ domain is involved in binding with Wnt ligands. Belongs to the secreted frizzled-related protein (sFRP) family.