Expressed in embryonic bone during primary endochondral ossification. Strong localization is observed in the perichondrium and periostium (at protein level). Also expressed in embryonic and postnatal brain and craniofacial tissues. Expressed in skeletal muscles (PubMed:26497270). Shows relatively low expression levels in proliferating myoblasts. Expression peaks at around day 1 of differentiation into myotubes and decreases again by day 10, when assayed in C2C12 cell line (at protein level). Up-regulated in response to denervation-induced skeletal muscle atrophy. Induced by MYOD1.