Required for normal inner ear hair cell function and hearing. TMEM132E is located in a region involved in a heterozygous deletion of approximately 4.7 Mb; this deletion, involving the NF1 gene and contiguous genes lying in its flanking regions, is observed in a patient with 17q11.2 microdeletion syndrome, a syndrome characterized by variable facial dysmorphism, intellectual disability, developmental delay, and an excessive number of neurofibromas. The disease is caused by variants affecting the gene represented in this entry. Belongs to the TMEM132 family. Artifactual sequence.