Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER) (By similarity). Component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis (PubMed:32820719). The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER (By similarity). The SEC61 channel-forming translocon complex consists of channel-forming core components SEC61A1, SEC61B and SEC61G and different auxiliary components such as SEC62 and SEC63 (By similarity). The ribosome-associated ER translocon complex includes SEC61A1, SEC61B, SEC61G, TMCO1, CCDC47, NCLN/Nicalin, NOMO and TMEM147; in the absence of ribosomes, only the complex forms with NCLN/Nicalin, NOMO and TMEM147 remains intact (PubMed:32820719). (Microbial infection) May interact with Zika virus strain Mr-766 non-structural protein 4A/NS4A (PubMed:30550790). May interact with Zika virus French Polynesia 10087PF/2013 non-structural protein 4A/NS4A (PubMed:30550790). (Microbial infection) May interact with Dengue virus DENV2 16681 non-structural protein 4A/NS4A. Belongs to the SecE/SEC61-gamma family.