Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 appears to be associated with myogenesis. In embryo, expressed in developing neural structures as well as in heart, branchial arches and limb buds. First expressed at stage 7 in the neural plate with lower expression in the midline. By stage 9, expressed through out the developing neural tube with lower levels in the future posterior mesencephalon and rhombomere 3. In anterior regions, highest expression in the dorsal neural tube and, more posteriorly throughout the closing neural tube. Also expressed in the ectoderm flanking the neural tube. In the developing brain, expression found in the presumptive forbrain. By stage 12, expression restricted to the dorsal prosencephalon, hindbrain and posterior neural tube. In the placodes, first expressed at stage 11, in the otic placode. By stage 15, expressed in the olfactory and epibranchial placodes. In facial primordia, expression found at stage 2,0 throughout the ectoderm. By stage 24, high mesenchymal expression in a small region of the posterior maxillary primordia, and in the lateral region of the mandibular primordia. By stage 28, expressed in a subset of muscles, including the intermandibularis muscle and the muscle medial to the eye. In the developing trunk, expression found throughout the dermamyotome in the more developed somites. By stage 20, expression restricted to the small region in the dorsal medial lip in all somites. In addition, also expressed in the ventral lateral lip of the dermamyotome that gives rise to the muscles of the limbs and body wall. During limb development, expressed between stages 20 and 30, in the proximal mesenchyme in association with developing muscles. Between stages 27 and 30, expression found in mesenchyme containing undifferentiated myogenic cells. In the developing heart, expression restricted to the myocardial and endocardial cell layers of the trabeculae in the ventricular compartment between stages 20 and 28. The FZ domain is involved in binding with Wnt ligands. Belongs to the secreted frizzled-related protein (sFRP) family.