Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. G alpha-2 is required for the early aggregation process and most of the known cAMP receptor-mediated responses (PubMed:2539262). Interacts with downstream effector gflB, a Rap guanine nucleotide exchange factor, to regulate the balance between Ras and Rap signaling at the leading edge of chemotaxing cells (PubMed:27237792). G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site (Probable). Interacts with the RAP guanine nucleotide exchange factor glfB (PubMed:27237792). Expression is induced by cAMP pulses and during aggregation. Ser-113 is transiently phosphorylated following stimulation with extracellular cAMP. Belongs to the G-alpha family.