May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. Interacts with PLK1; phosphorylation-dependent. The subcellular location is regulated during cell cycle. During interphase located in the nucleus. During mitosis located at the centrosome and dispersed in the cytoplasm. During telophase located in the midbody. Colocalizes with PLK1 at the centrosome in M phase. Expressed at highest levels in liver and kidney; intermediate expression in skeletal muscle, pancreas, heart and placenta; low expression in brain and lung. Expressed in epidermis and hair follicles. Phosphorylated during mitosis in the cell cycle probably by CDK1. The disease is caused by variants affecting the gene represented in this entry.