Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis (PubMed:12684533, PubMed:21176223, PubMed:22171324, PubMed:25653391, PubMed:32271860). In interphase cells, plays a role in anchoring and spatial arrangement of chromosome arms at the nuclear periphery, forming so-called lem-2 subdomains (PubMed:21176223). Both arms of autosomes but only the left arm of the X chromosome are anchored in lem-2 subdomains; sequences bound by lem-2 are mainly repetitive chromosome sequences and inactive genes (PubMed:21176223). Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina (PubMed:12684533). Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells (PubMed:22171324). Involved in the nuclear positioning and efficient anchoring of microtubule-organizing centers (MTOCs) to the nuclear envelope during mitosis as well as on maintaining correct nuclear morphology (PubMed:25653391). Contributes to closure of nuclear envelope (NE) holes and prevents excess nuclear membranes after meiosis and mitosis (PubMed:32271860). Together with emr-1, plays a role in baf-1 enrichment at the nuclear envelope in anaphase (PubMed:12684533). Together with emr-1, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization (PubMed:22171324). May play a role in radiation-induced DNA damage repair response (PubMed:22383942). Interacts with lmn-1 (PubMed:12684533). Interacts (via LEM domain and the C-terminal nuclear domain) with baf-1 (PubMed:12684533). Remains in the nuclear envelope until mid-late anaphase and reassociates with the chromatin periphery at telophase (PubMed:10982402). Recruited to the reforming nuclear envelope initially at the apical surfaces of chromatin, from where it spreads to the lateral surfaces facing the spindle microtubules (PubMed:25653391). Requires mel-28 for chromatin reassociation after mitosis and for nuclear envelope localization (PubMed:16950114). In meiosis at anaphase II, appears on the chromatin surface farthest from the extruding polar body (PubMed:32271860). After anaphase II, forms a plaque on the oocyte-derived pronucleus adjacent to the meiotic spindle (PubMed:32271860). Later disperses into a uniform rim around the oocyte-derived pronucleus (PubMed:32271860). Ubiquitous (PubMed:12684533). High expression in germline and intestine (PubMed:25653391). Expressed throughout development and in adults. Moderate increase in embryonic lethality of progeny of X-ray-irradiated adults (PubMed:22383942). Reduced lifespan to 18.6 days compared to 22 days for wild type animals (PubMed:22171324). Decreased contour ration of interphase nuclei, nuclear envelope invaginations and faster turnover of emr-1 at nuclear envelope (PubMed:25653391). Delay of daughter nuclei separation (PubMed:25653391). Two microtubule-organizing centers (MTOCs) found in close association with nuclei during nuclear separation instead of only one as in wild type animals (PubMed:25653391). RNAi-mediated knockdown leads to embryonic lethality and chromosome segregation defects in the F1 progeny (PubMed:12684533). Simultaneous knockout of lem-2 and emr-1 leads to embryonic lethality, 8.5% shorter animals in larval stage L2, abnormal gonads and a developmental stop at late L2/early L3 (PubMed:22171324). Missing cell divisions in the postembryonic mesodermal lineage and failure to produce any of the differentiated M lineage cells (PubMed:22171324). Defects in the organization of chromatin, nuclear intermediate filaments, and nuclear pore complexes (NPCs), and defects in mitosis in cells that continue to divide after embryogenesis (PubMed:22171324). In the mitotic zone of the gonad, lmn-1 and NPCs are mislocalized and nuclei are misshaped (PubMed:22171324). Misshaped nuclei with large lmn-1 aggregates, clustered NPCs and condensed chromatin in somatic hypodermal cells (PubMed:22171324). Defects in motility, sarcomere organization, and muscle attachment to hypodermis (PubMed:22171324). Decreased motility and near paralysis at day 6 (PubMed:22171324). Disorganized thin and thick filaments of sarcomeres and abnormally positioned muscles at day 3 and 6 (PubMed:22171324). Decreased pumping rate of the pharynx (PubMed:22171324). Simultaneous RNAi-mediated knockdown of lem-2 and emr-1 causes anaphase chromatin bridges and redistribution of baf-1 from the nuclear periphery to the segregating chromatin during anaphase (PubMed:12684533). RNAi-mediated knockdown in a cnep-1 mutant background leads to severe nuclear sealing defects (PubMed:32271860).