This potent antithrombotic agent acts in a calcium-independent manner. Exerts its anticoagulant effect by two distinct mechanisms. It binds to activated thrombin through exosite 1, blocking fibrinogen clotting, platelet activation, factor V activation and other effects, and it interacts with prothrombin (F2), decreasing its proteolytic activation -especially in the presence of factor Va. In vivo, intravenous injection before thrombosis induction causes a significant decrease in thrombus weight. Furthermore, BJC shows a prolonged effect by remaining in the plasma bound to prothrombin for at least 12 hours. Heterodimer of subunits alpha and beta; disulfide-linked. Expressed by the venom gland. Belongs to the snaclec family.