TAFs are components of the transcription factor IID (TFIID) complex that is essential for mediating regulation of RNA polymerase transcription. Required for the expression of a subset of ethylene-responsive genes (By similarity). Involved in the negative regulation of cytokinin sensitivity. Component of the TFIID complex. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) whose MWs range from 14-217 kDa. Can homodimerize. Interacts with PP2A1, PP2A5, ERF1B, EIN3, TAF4, TAF4B, TAF5, TAF8, TAF10, TAF11, TAF12, TAF13, TAF14, TAF14B, TAF15 and TAF15B (By similarity). Interacts with PKL. Expressed in roots. Not up-regulated by cytokinins. Hypersensitivity to cytokinins. Belongs to the TAF12 family. TAF12B in cv. Columbia (AC Q940A7) is 2 amino acids longer.