Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc) (By similarity). Part of the tectonic-like complex (also named B9 complex). Interacts with DNAJB9, DNAJC10 and mutated SFTPC. Interacts with SYNE2 during the early establishment of cell polarity. Interacts (via C-terminus) with FLNA. Interacts with TMEM218 (By similarity). Localizes at the transition zone, a region between the basal body and the ciliary axoneme. Defects in Tmem67 are the cause of Wistar polycystic kidney (wpk). Homozygous wkp rats develop nephromegaly, hypertension, proteinuria, impaired urine-concentrating capacity, and uremia, resulting in death at 4 week of age. Early cysts are present in the nephrogenic zone at embryonic day 19.