Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 175 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS. Interacts with GULP1, heparin, alpha-M/beta-2 integrin (ITGAM and ITGB2), and thymosin beta 4 (TMSB4X). Initially expressed in all vascular cells, including those of sinusoidal-like structures, vitellin veins, and hepatic veins or sinus venosus, in E13.5 fetal liver. The expression then progressively disappears in the portal and hepatic veins, but the expression in sinusoidals endothelial cells (SECs) is retained and becomes stronger during development. Recognizes phosphatidyl serine via its epidermal growth factor-like domains. Glycosylated. Proteolytically processed to yield a 175 kDa protein.