Rapidly hydrolyzes choline released into the synapse. acetylcholine + H2O = acetate + choline + H(+) Strains Kisumu and Kisumu2 are susceptible to insecticides while strain YAO is resistant. Insensitivity to insecticides results from a loss of sensitivity of acetylcholinesterase to organophosphates and carbamates and is due to a variant at position 280. Belongs to the type-B carboxylesterase/lipase family.