Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Acts as a ligand of the ADGRL1 receptor. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Induces gene transcription inhibition. Homodimer; disulfide-linked. Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4. Colocalizes with ADGRL1 across intercellular junctions. Expressed in the cortex, CA1, CA2, CA3, dentate gyrus and granular layer of the hippocampus. Expressed in the Purkinje cells and molecular layer of the cerebellum. Expressed in the midbrain and spinal cord at 12.5 dpc. EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds. Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins. Derives from the membrane form by proteolytic processing. Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity). Belongs to the tenascin family. Teneurin subfamily.