Negative regulator of the canonical Wnt signaling pathway involved in neuroectodermal patterning. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Interacts with APC. Translocates to the cell membrane following binding to PtdIns(4,5)P2. Belongs to the Amer family. Extended N-terminus. Truncated N-terminus.