Interacts with and disrupts the function of host retinoblastoma-related proteins RBR, which are key regulators of the cell cycle. Induces transcriptional activation of E2F-regulated S-phase and G2/M-phase-specific genes. Inactivation of the ability of RBR to arrest the cell cycle leads to the stimulation of viral DNA replication (By similarity). Interacts with host SKP1. Interacts (via LXCXE domain) with host retinoblastoma-related protein 1 (RBR1). Interacts (via LXCXE domain) with retinoblastoma-related proteins (RBR) (By similarity). Belongs to the nanovirus Clink protein family.