Deacetylase involved in the biosynthesis of butirosin by mediating deacetylation of 2'-N-acetylparomamine. 2'-N-acetylparomamine + H2O = acetate + paromamine Binds 1 zinc ion per subunit. Antibiotic biosynthesis; butirosin biosynthesis. Belongs to the PIGL family. Was initially thought to function as a nucleotidyltransferase (PubMed:15701005). But it was later shown that it is a deacetylase (PubMed:17226887).