Involved in the signal transduction pathway mediated by multiple Wnt genes. Interacts (via the PDZ domain) with the C-terminal regions of VANGL1 and VANGL2. Interacts (via the region containing both the PDZ and DEP domains) with LRRFIP2; the DIX domain may inhibit this interaction. Interacts with CYLD. Interacts with CEP164 and DAB2. Interacts with DCDC2. Interacts with FOXK1 and FOXK2 (By similarity). Interacts with DAAM2 (PubMed:22227309). Ubiquitous. Ubiquitinated. Deubiquitinated by CYLD, which acts on 'Lys-63'-linked ubiquitin chains (By similarity). Phosphorylated by CSNK1D. Arginine methylation may function as a switch in regulation of function in Wnt signaling. Belongs to the DSH family.