Specifically methylates the adenosine-1067 in 23S ribosomal RNA. Confers resistance to antibiotic nosiheptide. adenosine(1067) in 23S rRNA + S-adenosyl-L-methionine = 2'-O-methyladenosine(1067) in 23S rRNA + H(+) + S-adenosyl-L-homocysteine Homodimer. Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TsnR/AvirB family.