Receptor for interleukin-8 which is a powerful neutrophil chemotactic factor (PubMed:1891716). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Binds to IL-8 with high affinity. Also binds with high affinity to CXCL3, GRO/MGSA and NAP-2. Interacts with IL8 (PubMed:1891716). Interacts with GNAI2 (PubMed:8662698). Phosphorylated upon ligand binding; which is required for desensitization. (Microbial infection) Proteolytically cleaved by Staphylococcus aureus staphopain A/SspP. This cleavage inhibits CXCR2-dependent neutrophil activation and chemotaxis. The disease may be caused by variants affecting the gene represented in this entry. Belongs to the G-protein coupled receptor 1 family. CXC chemokine receptors entry