Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction. Main constituent of aortic medial amyloid. Located in the acrosomal region of zona-pellucida bound sperm. Mammary epithelial cell surfaces and aortic media. Overexpressed in several carcinomas. The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes. Medin has a ragged N-terminus with minor species starting at Pro-264 and Gly-273. It is unsure whether Met-1 or an upstream Met is the initiator as the upstream Met corresponds to polymorphism rs1879326.