Probably mediates the hydrolysis of some nucleoside diphosphate derivatives. In vitro, it can use both NADH and ADP-ribose as substrates; however the relevance of such substrates in vivo is unclear. ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate + 2 H(+) H2O + NAD(+) = AMP + beta-nicotinamide D-ribonucleotide + 2 H(+) H2O + NADH = AMP + 2 H(+) + reduced beta-nicotinamide D-ribonucleotide Divalent metal cations. Mg(2+) or Mn(2+). Expressed in stems and leaves. Weakly or not expressed in roots. Belongs to the Nudix hydrolase family.