Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Mediates axon guidance and homophilic and heterophilic cell-cell adhesion. May function as a cellular signal transducer (By similarity). Acts as a ligand of the ADGRL1 receptor. Induces gene transcription inhibition. Homodimer; disulfide-linked (Probable). Heterodimer with either TENM1 or TENM3. May also form heterodimer with TENM4 (By similarity). Interacts with ADGRL1 isoform 2. Colocalizes with ADGRL1 in synaptic junctions. Expressed in the brain (at protein level). From E17-E18 embryos, a very strong signal appeared and continued throughout the remaining prenatal days. The signal was strongest in the cerebral cortex (including the cingulate cortex, neocortex, and orbital and insular area), thalamus (anterior and intermediate thalamus), and weak in posterior thalamus and midbrain. EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds. Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins. Derives from the membrane form by proteolytic processing. Derives from the plasma membrane form by proteolytic cleavage and translocates to the nucleus. Homophilic binding of the C-terminal extracellular domain stimulates its proteolytic cleavage and release in the cytoplasmic. Is subjected to rapid degradation by the proteasome pathway (By similarity). Belongs to the tenascin family. Teneurin subfamily.