Probable core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. Required for developmentally programmed transitions from the G1 phase of the cell cycle to the G0 phase or the apoptotic pathway. Protein modification; protein ubiquitination. Component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex composed of cul-1, fsn-1, rpm-1 and skr-1 (PubMed:15208641). Interacts with Skp1-related proteins skr-1, skr-2, skr-3, skr-4, skr-7, skr-8, skr-9 and skr-10 (PubMed:11864566). Ubiquitous. Highest levels in embryos and lower levels in larvae and adults. Neddylated; which enhances the ubiquitination activity of SCF. Belongs to the cullin family.