Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases. a pyrimidine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a pyrimidine nucleobase a purine 2'-deoxyribonucleoside 5'-phosphate + H2O = 2-deoxy-D-ribose 5-phosphate + a purine nucleobase Inhibited by zinc ions. Competitive inhibition of dGMP hydrolysis by GMP and 6-methylthio-GMP. Optimum pH is 6.0 with dGMP or dCMP as substrate. Monomer and homodimer. Highly expressed in heart, kidney, liver and spleen. Weakly expressed in lung and skeletal muscle. Up-regulated in response to c-Myc and by partial hepatectomy. Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.