Efflux pump that contributes to intrinsic antibiotic resistance (PubMed:9811639, PubMed:12520088, PubMed:20525733, PubMed:30837962). The pump uses the electrochemical gradient as a source of energy (By similarity). Confers resistance to rifampicin (PubMed:20525733). Confers low-level resistance to tetracycline and to several aminoglycosides, including streptomycin, gentamicin, 2'-N-ethylnetilmicin and 6'-N-ethylnetilmicin (PubMed:9811639, PubMed:12520088). Inhibited by piperine, verapamil and verapamil analogs. Induced by rifampicin and ofloxacin. Point mutations found in this efflux pump in clinical isolates can play an important role in conferring clinically relevant resistance to multiple drugs, including pyrazinamide, and could explain some previously unaccounted drug resistance in clinical strains. Belongs to the major facilitator superfamily. Drug:H(+) antiporter-3 (DHA3) (TC 2.A.1.21) family.