Catalyzes ATP-dependent import of organic anions such as taurocholate and estrone sulfate (PubMed:12379217). In vitro, also imports ochratoxin A (PubMed:12379217). Also mediates cholesterol efflux independent of apolipoprotein, and plays a role in sphingomyelin production in oligodendrocytes (PubMed:23560799). Catalyzes ATP-dependent efflux of cholesterol and taurocholate (PubMed:29300488). Interaction with ABCA1 potentiates cholesterol efflux to lipid-free APOA1, which regulates high-density lipoprotein cholesterol levels (PubMed:28882873). ATP + H2O + taurocholate(in) = ADP + H(+) + phosphate + taurocholate(out) ATP + cholesterol(in) + H2O = ADP + cholesterol(out) + H(+) + phosphate ATP + estrone 3-sulfate(out) + H2O = ADP + estrone 3-sulfate(in) + H(+) + phosphate ATP + H2O + leukotriene C4(out) = ADP + H(+) + leukotriene C4(in) + phosphate ATP + H2O + taurocholate(out) = ADP + H(+) + phosphate + taurocholate(in) 17beta-estradiol 17-O-(beta-D-glucuronate)(out) + ATP + H2O = 17beta-estradiol 17-O-(beta-D-glucuronate)(in) + ADP + H(+) + phosphate Dofequidar (MS-209) and ochratoxin A inhibited the 17beta-estradiol 17-O-(beta-D-glucuronate) influx. Cholesterol efflux is increased by extracellularly applied taurocholate. Interacts with ABCA1; this interaction potentiates cholesterol efflux. Predominantly expressed on the sinusoidal plasma membrane. Widely expressed with higher expression in heart, skeletal muscle and liver (PubMed:12379217, PubMed:28882873, PubMed:29300488). Highly expressed in the superior frontal white matter and inferior temporal white matter (PubMed:12379217). Belongs to the ABC transporter superfamily. ABCA family. Extended N-terminus. Database for mutations in ABC proteins