Structural protein that stabilizes microvessels and muscle cells, both in heart and in skeletal muscle. Restin potently inhibits angiogenesis. Trimer; disulfide-linked. Interacts moderately with EFEMP2. Expressed predominantly in internal organs such as adrenal gland, pancreas and kidney. Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. O-glycosylated; with core 1 or possibly core 8 glycans. An N-terminal peptide contains chondroitin sulfate. Belongs to the multiplexin collagen family. The name restin has also been used for CAP-Gly domain-containing linker protein 1 the product of the CLIP1 gene.