NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH Optimum pH is 8.0 with pyridoxal as substrate (9.5 with L-fucose as substrate). Optimum temperature is 30 degrees Celsius. Cofactor degradation; B6 vitamer degradation; 4-pyridoxate from pyridoxal: step 1/2. Homodimer. Belongs to the aldo/keto reductase family.