Positively regulates macroautophagy in primary dendritic cells. Increases autophagic flux, probably by stimulating both autophagosome formation and facilitating tethering with lysosomes. Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through its FYVE-type zinc finger. Interacts (via RUN domain) with RAB7A. By IL4/interleukin-4 in dendritic cells. The RUN domain and the FYVE-type zinc finger are essential for its function in the positive regulation of macroautophagy. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Wrong choice of CDS.