Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium. Is highly enriched in brain. Accumulates postsynaptically in dendritic spines of neostriatal neurons. Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation. The N-terminus is blocked. Phosphorylated at Ser-36 by PHK and PKC. Phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions (By similarity). Belongs to the neurogranin family.