Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins. Interacts with PTF1A. Interacts with NEUROD2 (By similarity). Interacts with RUNX1T1. Interacts with AML1-MTG8/ETO (via nervy homology region 2 in oligomerized form) (PubMed:23812588). Interacts with BHLHA9 (PubMed:25466284). Expressed in several tissues and cell types including skeletal muscle, thymus, and a B-cell line. the 9aaTAD motif is a transactivation domain present in a large number of yeast and animal transcription factors. The disease is caused by variants affecting the gene represented in this entry.