Functions in the SND pathway, a SRP (signal recognition particle) and GET (guided entry of tail-anchored proteins) independent pathway for targeting a broad range of substrate proteins to the endoplasmic reticulum. SND functions in parallel to GET in targeting proteins with downstream hydrophobic motifs (PubMed:27905431). Involved in vacuolar processing and morphology (PubMed:21912603). Interacts with SND1, PHO88/SND3 and the translocon complex subunit SEC61. ENV10/SND2 and PHO88/SND3 form a complex with the translocon in the endoplasmic reticulum membrane. Exhibits cold sensitivity and leads to internal accumulation of precursor CPY. Belongs to the TMEM208 family.