Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia. Expressed in brain, kidney, and heart. Highest level in brain. In brain areas affected by ischemia. Administration of an antisense oligonucleotide specific for GPR17 significantly reduced brain damage following ischemia. Belongs to the G-protein coupled receptor 1 family.