May be involved in several stages of intracellular trafficking. Plays a role in protein transport from early to late endosomes. Plays a role in protein transport to the lysosome. Promotes degradation of EGFR after EGF signaling (By similarity). Homooligomer. Interacts with EGFR (By similarity). The PX domain mediates interaction with membranes enriched in phosphatidylinositol 3-phosphate. Belongs to the sorting nexin family.