Inhibits the voltage-gated sodium channels Nav1.1/SCN1A (IC(50)=360 nM), Nav1.2/SCN2A (IC(50)=600 nM), Nav1.3/SCN3A (IC(50)=1280), Nav1.4/SCN4A (IC(50)=330 nM), Nav1.6/SCN8A (IC(50)=1200 nM), Nav1.7/SCN9A (IC(50)=1-40 nM), and voltage-gated potassium channels Kv11.1/KCNH2 (IC(50)=4.8 uM) (PubMed:19955179, PubMed:30661758, PubMed:31234412). Induces analgesia in mammals (Ref.1). This analgesia is mediated by a non-opioid receptor related mechanism (Ref.1). Expressed by the venom gland. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. This toxin does not inhibit sodium channels Nav1.5/SCN5A, and potassium channels Kv1.1/KCNA1, Kv1.4/KCNA4, Kv11.2/KCNH6, Kv11.3/KCNH7 (IC(50)>200 uM). Belongs to the neurotoxin 30 (phrixotoxin) family.