The amidated Phylloseptin-1.2TR has weak antimicrobial activity against Gram-negative bacterium E.coli ATCC 25922 (MIC=100 uM), Gram-positive bacterium S.epidermidis ATCC 12228 (MIC=100 uM) and against fungus C.albicans ATCC 24433 (MIC=100 uM) (PubMed:29980138). Has an anti-inflammatory effect, since it inhibits the production of the pro-inflammatory cytokines TNF-alpha and IL-1 beta, and induces the production of the anti-inflammatory cytokine IL-10 (PubMed:30734396). Has an activity of stimulation of insulin release, which may protect the species from being eaten by predators by causing fatal hypoglycemia (PubMed:30734396). Is cytotoxic to cancer line cells (PubMed:30734396). Shows moderate hemolysis on mouse erythrocytes (LC(50)=75 uM) (PubMed:30734396). Expressed by the skin glands. Phylloseptin-1.2TR is amidated, whereas Phylloseptin-1.3TR is the name given to the non-amidated form. amidated Phylloseptin-1.2TR. non-amidated Phylloseptin-1.3TR. Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.