Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis. May act as autophagy receptor that interacts directly with both the cargo to become degraded and an autophagy modifier of the MAP1 LC3 family. Binds to linear ubiquitin chains. Interacts with LC3 family members (By similarity). Expressed in erythrocytes, skeletal muscle, heart, spleen and brain. Weakly expressed in lung and liver (at protein level). The LIR (LC3-interacting region) motif mediates the interaction with ATG8 family proteins. Ubiquitin-binding motif (UBAN) is essential for its inhibitory function, subcellular localization and interaction with TBK1.