NADP(+) + prephenate = 3-(4-hydroxyphenyl)pyruvate + CO2 + NADPH Amino-acid biosynthesis; L-tyrosine biosynthesis; (4-hydroxyphenyl)pyruvate from prephenate (NADP(+) route): step 1/1. Presence of Phe represses the TYR1 gene expression. Present with 2180 molecules/cell in log phase SD medium. Belongs to the prephenate/arogenate dehydrogenase family.