Does not appear to play a major role in virulence (PubMed:31140968). May play a role in titan cell formation (PubMed:31140968). A pair of annexin repeats may form one binding site for calcium and phospholipid. Increases titan cell formation (low penetrance) (PubMed:31140968). Low or no sensitivity to high temperature or tacrolimus (calcineurin inhibitor); sensitivity may be background dependent (PubMed:31140968). No cell population growth phenotype in a variety of conditions including high pH, low calcium, in presence of the antifungals amphotericin B or fluconazole, heavy metals (nickel or zinc), osmotic stress (NaCl), cell wall integrity stressors (Calcofluor White, caffeine, or Congo Red), oxidative stress (H2O2), or nitro-oxidative stress (NaNO2 or H2O2), or following ultraviolet light radiation (PubMed:31140968). Normal mating (PubMed:31140968). Normal virulence factor secretion; assayed using melanin and urease (PubMed:31140968). Normal virulence in mouse intranasal, intravenous, and intratracheal infection models or in an invertebrate infection model (PubMed:31140968). Normal survival rate following amoebal ingestion (PubMed:31140968). Belongs to the annexin family.