Probable ATP-dependent RNA helicase. Is required during post-transcriptional gene expression. May be involved in pre-mRNA splicing. ATP + H2O = ADP + H(+) + phosphate Identified in the spliceosome C complex (PubMed:11991638, PubMed:25920683). Interacts with ERCC6 (PubMed:26030138). Interacts with FAM50A (PubMed:32703943). Disease susceptibility is associated with variants affecting the gene represented in this entry. Belongs to the DEAD box helicase family. DDX41 subfamily. Intron retention.