During replicative cycle of retroviruses, the reverse-transcribed viral DNA is integrated into the host chromosome by the viral integrase enzyme. RNase H activity is associated with the reverse transcriptase. Endonucleolytic cleavage to 5'-phosphomonoester. a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) Specific enzymatic cleavages in vivo yield mature proteins. This protein is synthesized as a Gag-Pol polyprotein. Belongs to the retroviral Pol polyprotein family.