Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. Preferentially expressed at high levels in the retinal pigment epithelium (RPE) and Mueller cells of the neural retina. Covalently binds all-trans- and 11-cis-retinal. The disease is caused by variants affecting the gene represented in this entry. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. Retina International's Scientific Newsletter