Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity). Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:11159866, PubMed:18597632, PubMed:26051469). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:26051469). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (By similarity). Binds 1 zinc ion per subunit. Interacts with MEPE; the interaction is zinc-dependent (via ASARM motif). Expressed in bone, specifically in the osteoid and in osteocytes (PubMed:11159866, PubMed:18597632). Expressed in teeth, specifically in odontoblasts and ameloblasts (PubMed:11811562). Expressed moderately by macrophages in the liver and has minimal expression in brown adipose tissue (PubMed:11811562). Also expressed in suprabasal layers of the skin (PubMed:11811562). Detected at 16 and 18 days post coitum (dpc) in vertebrae osteoblasts. Detected in calvarial tissue and in the stratum spinosum and granulosum of the overlaying epidermis at 18 dpc. Detected at postnatal day 14 in osteoblasts and osteocytes of the calvarium. Detected in tibias at postnatal day 14 in osteoblasts and a lesser degree in osteocytes, however by postnatal day 84 it is detected in osteocytes in compact bone. Detected in teeth at postnatal day 14 in odontoblasts and ameloblasts. By postnatal day 84, expression can still be detected in odontoblasts however little to no expression can be detected in ameloblasts. Detected at 18 dpc at moderate levels in macrophages within the liver, with minimal expression in brown adipose tissue. Detected at 18 dpc in suprabasal layers of the skin. N-glycosylated. Belongs to the peptidase M13 family.