May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase. Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, an auxiliary non-catalytic beta subunit and an additional regulatory subunit. Expressed in the distal convoluted tubule in the kidney. Found on basolateral membranes of nephron epithelial cells. The disease is caused by variants affecting the gene represented in this entry. Belongs to the FXYD family. Wrong choice of frame.