May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Homodimer (Potential). Interacts with RAB11FIP2. Interacts with RALBP1, CRK and GRB2. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it to an EGF-responsive tyrosine kinase (By similarity). Interacts with AMPH, ITSN1 (via SH3 domains) and SGIP1; may be involved in clathrin-mediated endocytosis. Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. Widely expressed with highest levels in heart and testis. EGF stimulates phosphorylation on Tyr-residues. The disease is caused by variants affecting the gene represented in this entry. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus.