Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar development and synaptogenesis (By similarity). Component of a SWR1-like complex. Interacts with H2A.Z/H2AZ1 (By similarity). The H2A.Z-interacting domain (ZID) mediates a direct interaction with H2A.Z/H2AZ1. Phosphorylated. The phosphorylation is nuclear localization signal (NLS)-dependent (By similarity). Belongs to the ANP32 family.