Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. GST isoenzymes appear to play a central role in the parasite detoxification system. Other functions are also suspected including a role in increasing the solubility of haematin in the parasite gut. glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Homodimer. Tegument and in subtegumentary parenchymal cells. GST 26 may be actively excreted by adult worms. There are at least three isoenzymes of GST in S.mansoni. Belongs to the GST superfamily. Mu family.