Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). Expressed in the spinal cord, primarily in neurons of the lateral gray matter and in dorsal cells. Also expressed in reticulospinal neurons. Following spinal cord transection, it is strongly down-regulated at two weeks, during the period of axon dieback. Up-regulated at three weeks, when many axons are beginning to regenerate. Phosphorylated on cytoplasmic tyrosine residues. Belongs to the unc-5 family.