Activates long-chain fatty acids (LCFA) by esterification of the fatty acids into metabolically active CoA-thioesters for subsequent degradation or incorporation into phospholipids. Also facilitates the transport of LCFAs into the cell, either by active transport or by decreasing the intracellular LCFA concentration (PubMed:8206942, PubMed:11477098, PubMed:12601005, PubMed:27136724). It may supplement intracellular myristoyl-CoA pools from exogenous myristate. Preferentially acts on C12:0-C16:0 fatty acids with myristic and pentadecanic acid (C15:0) having the highest activities (PubMed:8206942). Also involved in long-chain base (LCB) uptake of sphingolipids. In contrast ot LCFA uptake, LCB uptake does not require ATP, suggesting that the enzyme is directly involved in active LCB uptake (PubMed:27136724). Involved in the sphingolipid-to-glycerolipid metabolic pathway, converting the shingolipid metabolite hexadecenoic acid to hexadecenoyl-CoA, which is then further converted to glycerolipids (PubMed:22633490). a long-chain fatty acid + ATP + CoA = a long-chain fatty acyl-CoA + AMP + diphosphate (9Z)-octadecenoate + ATP + CoA = (9Z)-octadecenoyl-CoA + AMP + diphosphate ATP + CoA + hexadecanoate = AMP + diphosphate + hexadecanoyl-CoA (9Z)-hexadecenoate + ATP + CoA = (9Z)-hexadecenoyl-CoA + AMP + diphosphate ATP + CoA + tetradecanoate = AMP + diphosphate + tetradecanoyl-CoA (9Z)-tetradecenoate + ATP + CoA = (9Z)-tetradecenoyl-CoA + AMP + diphosphate (9Z,12Z)-octadecadienoate + ATP + CoA = (9Z,12Z)-octadecadienoyl-CoA + AMP + diphosphate ATP + CoA + dodecanoate = AMP + diphosphate + dodecanoyl-CoA ATP + CoA + pentadecanoate = AMP + diphosphate + pentadecanoyl-CoA ATP + CoA + undecanoate = AMP + diphosphate + undecanoyl-CoA ATP + CoA + heptadecanoate = AMP + diphosphate + heptadecanoyl-CoA ATP + CoA + octadecanoate = AMP + diphosphate + octadecanoyl-CoA Optimum pH is 7.3-7.5. Optimum temperature is 30 degrees Celsius. Interacts with FAT1. The FACS motif is required for catalytic activity and substrate specificity. Present with 7470 molecules/cell in log phase SD medium. Belongs to the ATP-dependent AMP-binding enzyme family.