This protein binds specifically to 23S rRNA. The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome. Part of the 50S ribosomal subunit. Cells are erythromycin and tylosin resistant. Ery2 mutants (formerly called ery-M2) are cold-sensitive for growth at 15 degrees Celsius. Resistance and cold sensitivity are recessive to the wild-type allele. At least one mutant (ery2-4 formerly ery-M2d) has fewer chloroplast ribosomes than the wild-type. Belongs to the universal ribosomal protein uL22 family.