One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. A connexon is composed of a hexamer of connexins. Interacts with CNST (By similarity). The disease is caused by variants affecting the gene represented in this entry. The gene represented in this entry may act as a disease modifier. Belongs to the connexin family. Beta-type (group I) subfamily.