Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells. Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation. Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. Has sometimes been attributed to correspond to FcR-IIB. FCGR2C is both a gene and a pseudogene in the human population, the reference genome corresponding currently to the non-functional allele with a stop codon at position 57. The sequence shown here with a Gln at that position is the one of the functional protein.