Sesquiterpene synthase involved in the biosynthesis of (+)-epi-alpha-bisabolol, a precursor of the natural sweetner hernandulcin. (2E,6E)-farnesyl diphosphate + H2O = (+)-epi-alpha-bisabolol + diphosphate Binds 3 Mg(2+) ions per subunit. kcat is 0.04 sec(-1) for (2E,6E)-farnesyl diphosphate. Secondary metabolite biosynthesis; terpenoid biosynthesis. The Asp-Asp-Xaa-Xaa-Asp/Glu (DDXXD/E) motif is important for the catalytic activity, presumably through binding to Mg(2+). Belongs to the terpene synthase family. The taste of sweet - Issue 148 of May 2013