Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve (PubMed:26593267). Appears to be a potent inhibitor of regeneration following spinal cord injury (PubMed:12067236). Interacts with RTN4, UQCRC1 and UQCRC2. Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. Widely expressed in mitochondria-enriched tissues. Found in heart, kidney, liver, brain and spinal cord. Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.