Adenine glycosylase active on G:A and C:A mispairs, as well as processing 7,8-dihydro-8-oxoguanine:A (8-oxoG) mismatches. Hydrolyzes free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site. Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand. Loss of adenine glycosylase activity. No overall significant change in the mutation rate; an increase in C to A and A to C mutations (with a reduction in other mutations) is seen after rifampicin treatment. No change in susceptibility to H(2)O(2). Belongs to the Nth/MutY family. Extended N-terminus.