May play a role in junctional plaques. Interacts with DSC2. Interacts with JUP and desmoplakin/DSP. Nuclear and associated with desmosomes. Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata. The disease is caused by variants affecting the gene represented in this entry. Undetected in heart. Major isoform in heart. Belongs to the beta-catenin family.