Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + H(+) + S-adenosyl-L-homocysteine Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle. Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.