Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (By similarity). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (PubMed:24760852). ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-[protein] ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-threonyl-[protein] Interacts with ESR1 (By similarity). Interacts with AP-2 complex subunit alpha (PubMed:24760852). Punctate pattern in cell projections. Expressed in brain. Predominantly expressed in cerebral cortex, thalamus, the cerebellum and hippocampal formation (at protein level). Up-regulated during postnatal development, and expressed in adult stage. Autophosphorylated. Viable and grossly normal. Mice exhibit prominent behavioral abnormalities, including locomotor hyperactivity, reduced anxiety, and decreased depression-like behavior. Belongs to the protein kinase superfamily. Tyr protein kinase family.