Involved in the perception of CLV3 and CLV3-like (CLE) peptides, that act as extracellular signals regulating meristems maintenance. Required for the sensing of the root CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45), which involves also CRN and leads to root growth regulation, mostly in the phloem and protophloem (PubMed:28607033). Involved in controlling the stem cell population size in shoot and root apical meristems, and during organ development. Promotes the formation of CLV1 multimers. In complex with CRN, perceives secreted CLV3-like effector proteins from plant-parasitic cyst nematodes as ligand mimics of the plant CLE signaling pathway (PubMed:21265896, PubMed:21750229). This recognition is required for proper feeding structure (syncytium) development and ultimately successful nematode infection (PubMed:21265896, PubMed:21750229). CLE14 perception by CLV2/CRN complex triggers root meristem differentiation (PubMed:20697738, PubMed:28586647). Parts of a tetrameric complex made of two CLV2/CRN heterodimers that can interact with CLV3 and CLE peptides. CLV2/CRN heterodimer interacts with CLV1 homodimers. Interacts with CRN; this dimer can interact with BAM3 (PubMed:28607033, PubMed:27229734). Interacts with CLE14 (PubMed:28586647). Requires CRN for export from the endoplasmic reticulum and localization to the plasma membrane. Mostly expressed in apices (e.g. shoot apical meristem and flower buds), and, to a lower extent, in flowers, leaves, seedlings and siliques. Also expressed in the inner tissues of the proximal root meristem (PubMed:21265896). Expressed throughout the vascular cylinder of root tips (PubMed:28607033). In roots, mostly expressed in the stele and young epidermis cells and, to a weaker extent, in endodermis, cortex and differentiated columella cells. Insensitivity to root growth regulation by root CLE peptides (e.g. CLE8, CLE9/CLE10, CLE11, CLE13, CLE14, CLE16, CLE17, CLE18, CLE20, CLE21, CLE25, CLE26, CLE40, CLE41/CLE44 and CLE45) (PubMed:28607033). Impaired interaction with CRN (PubMed:27229734). Stem cell proliferation leading to enlarged shoot and flower meristems, as well as alterations in the development of the gynoecia, flower pedicels, and stamens. Reduced sensitivity to CLV3, CLE19 and CLE40 peptides. Ectopic fruit organ initiation after floral meristem termination (PubMed:21705761). Enhanced resistance to nematode infection (PubMed:21265896). Enhanced disease resistance response to the bacterial pathogen Ralstonia solanacearum and to the biotrophic oomycete pathogen Hyaloperonospora arabidopsidis (PubMed:26990325). Belongs to the RLP family.