Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706). Interacts with FBXW7; promotes FBXW7 degradation (PubMed:24344117). May interact with RAF1 (PubMed:24736947). Interacts with KIF22; recruits KIF22 to mitotic spindle microtubules (PubMed:18485706). Interacts (via C-terminus) with DYNLL1 (PubMed:22965910). Interacts with HMMR (PubMed:22965910). Interacts (via N-terminus) with CSNK1A1/CK1a; in mitotic cells (PubMed:31338967). Primarily cytoplasmic during interphase, but at prophase, associates with spindle microtubules, with a clear concentration toward the spindle poles. It persists on spindle microtubules through metaphase and anaphase. Expressed in the testis. Up-regulated during mitosis. Phosphorylated during mitosis. Probable proto-oncogene that regulates cell proliferation, growth, migration and epithelial to mesenchymal transition (PubMed:24344117, PubMed:24736947, PubMed:25646692). Expression increased in hepatocellular carcinoma, promotes proliferation and cell colony formation via activation of MEK/ERK signaling (PubMed:25646692). Expression increased in breast cancer; may be a prognostic indicator of poor disease-free survival (PubMed:24344117). Was named CHICA (girl in Spanish) because it interacts with KID. Belongs to the FAM83 family. Extended N-terminus. Extended N-terminus. Extended N-terminus. Extended N-terminus. Extended N-terminus. Extended N-terminus. Truncated C-terminus.