Toxin with different activities on acid-sensing ion channels 1 and 3 (PubMed:32326130). It weakly and reversibly inhibits rat homomeric ASIC1 (isoform ASIC1a) (IC(50)=1.25 uM), while it potentiates rat homomeric ASIC3 (EC(50)=1.53 uM) (PubMed:29684594, PubMed:32326130). ASIC1a current inhibition is not complete, and reaches a maximum of 86% inhibition (PubMed:32326130). On ASIC3, this toxin does not activate the channel itself, but produces a remarkable potentiation of the transient current resulting from the acidic pulse (PubMed:32326130). At the maximal applied concentration, it elicits responses that are twice as high as those produced by extracellular protons (PubMed:32326130). Molecular modeling interaction with ASIC1a suggests that this peptide hinders the collapse of acidic pockets and stabilize nonconducting channels state (PubMed:32326130). Contains disulfide bonds. Belongs to the sea anemone type 3 (BDS) potassium channel toxin family.