Pump for glutathione S-conjugates. Involved in regulation of K(+) and Na(+) cell content. Mediates resistance to NaCl and Li(+), confers sensitivity to sulfonylurea drugs such as glibenclamide (inducer of stomatal opening), and required for stomatal opening regulation by auxin, abscisic acid (ABA) and external Ca(2+). Transports oestradiol-17-(beta-D-glucuronide) (E(2)17G). Involved in the root auxin content regulation that controls the transition from primary root elongation to lateral root formation. Plays a role in ABA-mediated germination inhibition (PubMed:11296221, PubMed:11855639, PubMed:12943546, PubMed:14684837). High-affinity inositol hexakisphosphate transporter that plays a role in guard cell signaling and phytic acid storage. Required for phytic acid accumulation in developing seeds. Phytic acid is the primary storage form of phosphorus in cereal grains and other plant seeds (PubMed:19797057). ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2. (E(2)17G) transport activity in negatively regulated by organic anions such as oestradiol-3-sulfate, luteolin-7-O-diglucuronide-4'-O-glucuronide, glycocholate, vanadate and the sulfonylurea glibenclamide, and, to a lower extent, by bafilomycin A1, NH(4)Cl, GSH, GSSG and DNB-GS. A number of isoforms are produced. According to EST sequences. Ubiquitous, mostly in vascular tissues and epidermis, including guard cells. In flowers, present in anthers central vascular strand of the filament and in connecting tissues of the pollen sacs. Also present at the silique attachment site of the pedicel. Increased water use efficiency (PubMed:12943546). Low phytic acid levels in seed tissue (PubMed:19797057). Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.