May play a role in microtubule stabilization. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Homodimer or heterodimer with MID1. Interacts with IGBP1. Microtubule-associated. Low level in fetal kidney and lung, and in adult prostate, ovary and small intestine. The tripartite motif (RBCC; RING- and B box-type zinc fingers and coiled coil domains) mediates dimerization. Associates with microtubules in a manner that is dependent on the C-terminal B30.2 domain. Phosphorylated on serine and threonine residues. The disease is caused by variants affecting the gene represented in this entry. Belongs to the TRIM/RBCC family. It is uncertain whether Met-1 or Met-21 is the initiator. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus.