Plays important role in immediate-early gene expression through interaction with UL82. Forms nuclear bodies in host nucleus, independently of PML. In turn, UL35 nuclear bodies associate with and remodel PML bodies (PubMed:22072767, PubMed:21489587). Through interaction with host DCAF1, causes cells to accumulate in the G2 phase of the cell cycle by inducing a DNA damage response (PubMed:22072767). Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5 (PubMed:29444945). Also plays a role in the inhibition of pattern recognition receptor-mediated type I interferon signaling at the level of TBK1 (PubMed:32466380). Promotes cytoplasmic UL82 accumulation and inhibits UL35-containing nuclear bodies formation (PubMed:21489587). Regulates viral assembly by controlling the localization of the essential gB through regulation of a retrograde transport pathway. This modulation occurs via binding and inhibition of host sorting nexin 5/SNX5 (PubMed:29444945). Interacts with UL82 (PubMed:15308743). Interacts with isoform UL35A. Interacts with host UBP7; this interaction significantly inhibits the ability of USP7 to form nuclear bodies (PubMed:22072767). Interacts with host DCAF1 (via C-terminus)(PubMed:22072767). Interacts with host SNX5; this interaction allows proper gB localization during viral assembly (PubMed:29444945). Interacts wth host TBK1; this interaction prevents type I interferon production (PubMed:32466380). Interacts with UL82. Interacts with isoform UL35. Interacts with host UBP7; this interaction significantly inhibits the ability of USP7 to form nuclear bodies (PubMed:22072767). Interacts with host SNX5; this interaction allows proper gB localization during viral assembly (PubMed:29444945). Found in nuclear bodies. Belongs to the herpesviridae pp85 family.