May be involved in vasopressin signaling in the kidney. Homooligomer (By similarity). Interacts (via SAM domain) with ANKS6 (via SAM domain) (PubMed:25671767, PubMed:26327442, PubMed:26188091). Interacts with BICC1 (PubMed:25671767). Interacts with NPHP1 (PubMed:25671767). Interacts with NEK8 (PubMed:25671767, PubMed:26188091). Interacts with HIF1AN (PubMed:25671767). Interacts with NEK7; this interaction alters the subcellular distribution of NEK7 by preventing its nuclear translocation (PubMed:26188091). Kidney (at protein level). The SAM domain mediates homooligomerization. Hydroxylated at Asn-96, most probably by HIF1AN. Phosphorylations at Ser-5, Ser-225, Thr-318, Ser-319, Ser-366 and Ser-369 occur in a NEK7-dependent manner. Polyubiquitinated.