Mediates electroneutral potassium-chloride cotransport. May be activated by cell swelling. May contribute to cell volume homeostasis in single cells. Activated by N-ethylmaleimide (NEM). Inhibited by DIOA, bumetanide and furosemide. Inhibited by WNK3. Homomultimer and heteromultimer with other K-Cl cotransporters. Highly expressed in heart, brain and kidney. Detected at lower levels in skeletal muscle, placenta, lung and pancreas. Detected in umbilical vein endothelial cells. Isoform 2 is more abundant in kidney. Isoform 5 is testis specific. Expressed in the proximal tubule of the kidney (at protein level). Up-regulated by VEGF. Down-regulated by TNF. N-glycosylated. The disease is caused by variants affecting the gene represented in this entry. Produced by alternative promoter usage. Does not differ in the osmotic set point of swelling activation but, activation is more rapid. Does not differ in the osmotic set point of swelling activation but, activation is more rapid. Belongs to the SLC12A transporter family.