5' to 3' helicase that unwinds RNA and DNA duplexes in an ATP-dependent reaction (By similarity). Specific to 5'-phosphorylated single-stranded guanine-rich sequences (By similarity). May play a role in RNA metabolism, ribosome biogenesis or initiation of translation (By similarity). May play a role in regulation of transcription (PubMed:11106437). Interacts with tRNA-Tyr (By similarity). ATP + H2O = ADP + H(+) + phosphate ATP + H2O = ADP + H(+) + phosphate Homooligomer (By similarity). Interacts with RUVBL1 (By similarity). Interacts with RUVBL2 (By similarity). Interacts with GTF3C1 (By similarity). Interacts with ABT1 (By similarity). Interacts with ribosomes (By similarity). Expressed in liver, skin, muscle, heart, brain, spleen and kidney. The R3H domain recognizes phosphorylated 5'-ends of single-stranded nucleic acids which promotes binding of nucleic acids and stimulates ATPase activity. Belongs to the DNA2/NAM7 helicase family.