Transcription factor. Interacts specifically with the W box (5'-(T)TGAC[CT]-3'), a frequently occurring elicitor-responsive cis-acting element. Acts also as a disease resistance protein involved in resistance to fungal and bacterial pathogens, including R.solanacearum, P.syringae pv. tomato and C.higginsianum. Heterodimerization with RPS4 is required to form a functional complex to recognize AvrRps4 and PopP2 (PubMed:24744375). Contributes to temperature-conditioned RPS4 auto-immunity (PubMed:24146667). Interacts with PopP2, a R.solanacearum type III effector (PubMed:12788974). Interacts with RPS4 (PubMed:24744375). The nuclear localization is only detected upon interaction with PopP2. The TIR does not cause cell death, but can suppress RPS4 TIR domain-induced cell death (PubMed:24744375). The TIR domain is involved in homo- and heterodimerization, but other domains also contribute to the interaction (PubMed:24744375). Ecotypes susceptible to C.higginsianum or R.solanacearum, such as cv. Columbia, contain a protein with a premature stop codon, while the longer allele found in cv. Nd-1, cv. Wassilewskija or cv. RLD confers resistance. May be due to intron retention. Belongs to the disease resistance TIR-NB-LRR family. Was originally thought to correspond to two different genes At5g45260 and At5g45270. Was originally thought to correspond to two different genes At5g45260 and At5g45270. Functional and comparative genomics of disease resistance gene homologs