Tyrosine-rich conopeptide that specifically targets voltage-gated potassium channel Kv1.6/KCNA6 (IC(50) is 8.8 uM) that is expressed in Xenopus oocytes. In vivo, causes seizures (at 5 nmol) and death (20 nmol) when intracranially injected into mice, and causes paralysis (at 10 pmol) to C.elegans. Expressed by the venom duct. Dose that causes mild to moderate seizure (ED(50)) is 5 nmol when intracranially injected into mice. With 20 nmol injected per mouse, most of the mice developed severe seizures and died. The mature peptide does not contain cysteine residues. Does not inhibit Kv1.2/KCNA2 (IC(50) is >30 uM), Kv1.3/KCNA3 (IC(50) is >50 uM), Kv1.4/KCNA4 (IC(50) is >50 uM), Kv1.5/KCNA5 (IC(50) is >50 uM). Seems also ineffective on Kv1.1/KCNA2, Kv2.1/KCNB1, Kv3.4/KCNC4, and Nav1.2/SCN2A (PubMed:18505731). Belongs to the conotoxin M superfamily. Conopeptide Y family.