Could function as an adhesive molecule and its matrix bound and soluble fragments may play a critical role in vascular biology. Forms homooligomers and heterooligomers with SCUBE2 and SCUBE3. Expressed predominantly in the developing gonad, nervous system somites, surface ectoderm and limb buds. Down-regulated by inflammatory cytokines. N-glycosylated. Could be proteolytically cleaved to release a smaller active fragment.