Plays a role in regulating Notch activity (Probable). Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. Required during embryogenesis for inner mass cell survival. Highest expression in heart, brain, lung, liver, skeletal muscle and testis with lower levels in spleen and kidney. Expression detected in the embryo at 7.0 dpc, 11.0 dpc and 15.0 dpc and also in the adult. Embryonic lethality prior to 6.5 dpc with death of inner mass cells. Embryos implant but die shortly after.