This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction. Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN (PubMed:11433297). Interacts (via IQ domain) with calmodulin (PubMed:18493953). Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence (By similarity). Cytoplasmic surface of growth cone and synaptic plasma membranes. Expressed in the hippocampus (at protein level) (PubMed:18493953, PubMed:11573004). Expressed in the dorsal root ganglion and the spinal cord (at protein level) (PubMed:28111162). Up-regulated after memory training in radial arm maze experiments (PubMed:11573004). Up-regulated after sciatic nerve injury (PubMed:28111162). Phosphorylated (PubMed:18493953). Phosphorylation of this protein by a protein kinase C is specifically correlated with certain forms of synaptic plasticity (By similarity). Palmitoylated by ZDHHC3 (PubMed:27875292). Palmitoylation is regulated by ARF6 and is essential for plasma membrane association and axonal and dendritic filopodia induction. Deacylated by LYPLA2 (By similarity). Belongs to the neuromodulin family.