Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). Homotrimer; disulfide-linked. Interacts with LAMA2 (By similarity). Interacts with FBN1 (via N-terminal domain). Forms a ternary complex with ELN and FBN1 (PubMed:17255108). Component of both basement membranes and other connective tissues. Expressed in heart, placenta and ovary. Widely expressed during embryonic development. Primarily detected within the neuropithelium, spinal ganglia and peripheral nerves. O-glycosylated with core 1 or possibly core 8 glycans. It is unsure if the O-glycosylation is on Thr-347 or Ser-348. Belongs to the fibulin family.