N-glycosylase that inhibits protein synthesis in the host by depurinating ribosomal rRNA, and thus acts as a ribosomal inactivating protein (RIP) (PubMed:33462434). Promotes vascular permeability in the host and induces necrosis and apoptosis of host alveolar epithelial cells (PubMed:33462434). Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. Induced during germination and expressed during hyphal growth (at protein level) (PubMed:33462434). Not expressed in spores (at protein level) (PubMed:33462434). Repressed by hypoxic conditions. RNAi-mediated knockdown decreases cytotoxicity in vitro and decreases virulence in a mouse model of infection (PubMed:33462434). RNAi-mediated knockdown has no effect on the germination or cell population growth of the fungus (PubMed:33462434). Antibodies against the toxin protects mice from mucormycosis and thus could potentially be used to treat the disease. Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.