The enzyme prefers aromatic over aliphatic amines. an aliphatic amine + H2O + O2 = an aldehyde + H2O2 + NH4(+) 2-phenylethylamine + H2O + O2 = 2-phenylacetaldehyde + H2O2 + NH4(+) Binds 1 copper ion per subunit. Can also use zinc ion as cofactor (By similarity). Binds 2 calcium ions per subunit. Contains 1 topaquinone per subunit. Binds 1 Mn(2+) ion per subunit. Inhibited by 2-hydrazinopyridine. Amino-acid degradation; L-phenylalanine degradation; phenylacetate from L-phenylalanine: step 2/3. Homodimer. Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. Belongs to the copper/topaquinone oxidase family. When highly overexpressed there can be substoichiometric amounts of TPQ in the enzyme; this may be due to imperfect conversion of tyrosine to TPQ (see PubMed:8647101).