Delta-conotoxins bind to site 6 of voltage-gated sodium channels (Nav) and inhibit the inactivation process (By similarity). However, this toxin interacts with a conserved hydrophobic triad (YFV) in the domain-4 voltage sensor of sodium channels. Expressed by the venom duct. The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. The cysteine framework is VI/VII (C-C-CC-C-C). Sequence shown. Variant Glu-52. Belongs to the conotoxin O1 superfamily.