Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate-recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor (Probable). Interacts with cul-1, cul-2, cul-3, cul-4, cul-5 and cul-6. In early embryos, expressed in all cells. Expression is higher during early stages and is reduced in late-stage embryos. Present in the one-cell stage zygote, indicating it is provided as a maternal product by the hermaphrodite parent. During larval stages, expressed in proliferative cell lineages, including the seam cells, intestine, P-lineage cells, somatic gonad, and germline. Also observed in a subset of non-proliferative tissues, including hypodermal cells (at protein level). Worms show impenetrant phenotypes, including developmental arrest, morphological defects of the vulva and tail and reduced fecundity. Worms also display supernumerary seam cell divisions, defective alae formation, and the accumulation of the SCF(lin-23) target, the glutamate receptor glr-1. Increased levels of the neddylated isoforms of Cul-2 and cul-4. Belongs to the CAND family.