Catalyzes the attachment of valine to tRNA(Val). ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val) Can be regulated by protein kinase C-dependent phosphorylation. Forms high-molecular-mass aggregates with elongation factor 1. The disease may be caused by variants affecting the gene represented in this entry. Belongs to the class-I aminoacyl-tRNA synthetase family.