Attaches the virus to host cellular receptor, inducing clathrin-dependent endocytosis of the virion. In the endosome, the acidic pH induces conformational changes in the glycoprotein trimer, which trigger fusion between virus and endosomal membrane. In neurons, neo-synthesized glycoproteins are sorted to the dendrites, where the virus buds (By similarity). Homotrimer. The cytoplasmic domain sorts the protein to neurons dentrites instead of axons. When expressed in ex vivo polarized cells like epithelial cells, it sorts the protein to the basolateral side (By similarity). Glycosylated by host. Palmitoylated by host on Cys-489 (By similarity). Used to pseudotype many virus-like particles like lentiviral vector, because of its broad spectrum of host cell tropism. Also used in viral vectors studies in cancer therapy. Belongs to the vesiculovirus glycoprotein family.