Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. a (3R)-3-hydroxyacyl-CoA + NAD(+) = a 3-oxoacyl-CoA + H(+) + NADH a (3R)-3-hydroxyacyl-CoA = a (2E)-enoyl-CoA + H2O Catalytic efficiency is similar using full-length protein or the individual (3R)-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase 2 domains in a 1:1 mixture. Lipid metabolism; fatty acid beta-oxidation. Homodimer. Complements functionally the S.cerevisiae peroxisomal MFE-2 in vivo. Belongs to the short-chain dehydrogenases/reductases (SDR) family.