Involved in intestinal colonization, displays in vitro mucinolytic activity, serum resistance, and hemagglutination. Important to penetrate the intestinal mucus layer. Optimum pH is 7.0-9.0. Optimum temperature is 37 degrees Celsius. The cleaved C-terminal fragment (autotransporter domain) is localized in the outer membrane. The signal peptide, cleaved at the inner membrane, guides the autotransporter protein to the periplasmic space. Then, insertion of the C-terminal translocator domain in the outer membrane forms a hydrophilic pore for the translocation of the passenger domain to the bacterial cell surface, with subsequent cleavage (By similarity). Cleaved to release the mature protein from the outer membrane.