E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Interacts with DVL1 and SSR3. Named isoforms=2. Predominantly expressed in neurons of the spinal cord.