Key virulence factor required for mycobacterial survival within host macrophages (By similarity). Exhibits protein tyrosine phosphatase activity (By similarity). Supports mycobacteria survival during infection by modulation of the phagosome maturation and modulation of the normal host signaling pathways, including host innate immune responses and cell apoptosis. H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate Belongs to the low molecular weight phosphotyrosine protein phosphatase family.