The amidated peptide increases the release of nitric oxid (NO) and that NO mediates the endothelium-dependent vasodilatation. In addition, it inhibits efficiently angiotensin I-converting enzyme (ACE) in rat serum (IC(50)=8.2 uM). 3D-structure modeling of this peptide in complex with ACE suggests it acts by inhibiting the ACE C-terminal catalytic site. Expressed by the skin gland. Both amidated and non-amidated peptides have been observed in skin secretions. non-amidated. amidated. Belongs to the bradykinin-potentiating peptide family.