Acts as a functional chemokine, inducing calcium mobilization, chemotaxis, and degranulation of neutrophils. Contributes to the induction of neutrophil chemotaxis by interacting with host CXCR1 and CXCR2 receptors. Interacts with host CXCR1 and CXCR2. Belongs to the intercrine alpha (chemokine CxC) family.