Acts as a negative regulator of fluconazole resistance, primarily through down-regulation of the ABC transporter gene CDR1 via inactivation of the PDR1 transcriptional pathway. Leads to fluconazole resistance and activates genes of the PDR1 regulon including CDR1, YBT1, YOR1, RSB1, RTA1, PDH1, and NCE103; as well as PDR1-independent adhesion-related genes such as EPA1, EPA2, and EPA3.