Alpha-conotoxins bind to the nicotinic acetylcholine receptors (nAChR) and inhibit them. This toxin inhibits rodent (alpha-1-beta-1-delta-epsilon > alpha-1-beta-1-delta-gamma) and human (alpha-3-beta-1) nAChRs heterologously expressed in Xenopus oocytes, but has minimal effect on human alpha-7 nAChRs. Has no effect on the frequency of responses from the giant fiber (GF)-dorsal longitudinal and GF-tergo trochanteral muscle pathways in the D.melanogaster GF circuit (PubMed:28917942). Has possibly a distinct nAChR binding mode from other alpha-conotoxins, due to a different three residue motif (lacks the Ser-Xaa-Pro motif) (By similarity). Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/7 pattern. A non-hydroxylated version of this conotoxin has been synthesized. Hydroxylation of Pro-7 seems to increase the inhibition of rodent alpha-1-beta-1-delta-epsilon and alpha-1-beta-1-delta-gamma nAChRs. Belongs to the conotoxin A superfamily.