Regulates maturation and trafficking of the transmembrane metalloprotease ADAM10 (PubMed:26668317, PubMed:23035126). Negatively regulates ADAM10-mediated cleavage of GP6 (PubMed:26668317). Promotes ADAM10-mediated cleavage of CDH5 (PubMed:23035126). Interacts with ADAM10; the interaction promotes ADAM10 maturation and cell surface expression. Belongs to the tetraspanin (TM4SF) family.