Orphan receptor. Mainly expressed in skin and heart, and very weakly in lung and spleen. Detected in all epidermal layers of skin. Expressed during embryonic development in the skin starting at embryonic day 12 with the formation of the basal layer of the skin. No visible phenotype. Most adhesion GPCRs undergo autoproteolysis at the GPS domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the lack of a consensus catalytic triad sequence within GPS domain. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.