Plays a role as a potent and selective agonist of PTH2R resulting in adenyl cyclase activation and intracellular calcium levels elevation. Induces protein kinase C beta activation, recruitment of beta-arrestin and PTH2R internalization. May inhibit cell proliferation via its action of PTH2R activation. Neuropeptide which may also have a role in spermatogenesis. May activate nociceptors and nociceptive circuits. Ligand of high affinity for the PTH2 receptor (PTH2R). The N-terminal truncation of tuberoinfundibular peptide of 39 residues [TIP39(7-39)] reverses PTH2R/PTHR1 binding selectivity, then is a highly potent and selective antagonist for PTHR1. It displays a more favorable in vitro pharmacological profile than antagonists derived from the structure of PTH or PTHLH. Belongs to the parathyroid hormone family.