May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro) (By similarity). Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy. Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3. Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1. May be involved in autophagosome biogenesis. May play a role in neural progenitor cell survival during differentiation (By similarity). Interacts with PPARD and PPARG (By similarity). Interacts with SCOC (By similarity). Interacts with PPARA. Interacts with THRB, RARA, RARG and RXRA in the presence of bound ligand. Associates with the PI3K complex I (PI3KC3-C1); the direct binding partner in the complex is reported variably as PIK3R4 or ATG14 (By similarity). Belongs to the NRBF family.