May coordinate the cellular actions of activated EGF receptors and Ral-GTPases. Homodimer (Potential). Interacts with RALBP1, CRK and GRB2. Binding to RALBP1 does not affect its Ral-binding activity. Forms a complex with the SH3 domains of CRK and GRB2 which may link it to an EGF-responsive tyrosine kinase. Interacts with RAB11FIP2 (By similarity). Interacts with AMPH, ITSN1 (via SH3 domains) and SGIP1; may be involved in clathrin-mediated endocytosis (By similarity). Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits. Expressed in all tissues examined. The highest level expression was found in the kidney and testis. EGF stimulates phosphorylation on Tyr-residues. Due to intron retention.