Probable guanine nucleotide exchange factor which regulates the Rho GTPase rho-1. Functions in ASE sensory neurons where it promotes neuronal degeneration under conditions of oxidative stress. Expressed in muscles in the body wall and head, and in the nervous system in neurons including FLP and ASE neurons in the head. Viable with normal development, size and lifespan. Reduced sensitivity to factors that induce neurodegeneration. Improved chemosensory response in aging worms.