Terpene cyclase that is able to convert FPP into a mixture of sesquiterpene hydrocarbons and alcohols (PubMed:31418991). The main product is trichobrasilenol (PubMed:31418991). Additionally, side products include alpha-humulene, caryophyllene, 2-epi-caryophyllene, african-3-ene, african-1-ene, isoafricanol and pristinol (PubMed:31418991). Does not accept GPP, GGPP, and GFPP as substrates (PubMed:31418991). (2E,6E)-farnesyl diphosphate + H2O = diphosphate + trichobrasilenol (2E,6E)-farnesyl diphosphate = alpha-humulene + diphosphate (2E,6E)-farnesyl diphosphate = (-)-(E)-beta-caryophyllene + diphosphate (2E,6E)-farnesyl diphosphate = (E)-2-epi-beta-caryophyllene + diphosphate (2E,6E)-farnesyl diphosphate + H2O = (+)-isoafricanol + diphosphate (2E,6E)-farnesyl diphosphate + H2O = (+)-(2S,3R,9R)-pristinol + diphosphate (2E,6E)-farnesyl diphosphate = african-3-ene + diphosphate (2E,6E)-farnesyl diphosphate = african-1-ene + diphosphate Binds 3 Mg(2+) ions per monomer. Sesquiterpene biosynthesis. Homodimer. The 2 conserved active-site motifs D(D/E)XX(D/E) and NSE are required for coordinating the divalent metal ions that stabilize the PPi moiety of the substrate. The C-terminal WxxxxxRY motif is frequently found in terpene synthases and is important to guide product formation. Abolishes the production of koraiol. Belongs to the terpene synthase family.