Has cytotoxic activity towards cancer cells, but not normal cells. Inhibits the growth of the human leukemia cell line K562, the murine melanoma cell line B16 and the lung adenocarcinoma cell line A549 with IC(50) values of 88.1 nM, 63.4 nM and 359.3 nM respectively. Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA. The N-linked glycan consists of GlcNAc2Man3Xyl. Belongs to the ribosome-inactivating protein family. Type 1 RIP subfamily.