Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Cannot metabolize 1-chloro-2,4-dinitrobenzene. glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Homodimer. Selectively expressed in gall bladder, colon, heart, and skeletal muscle. Belongs to the GST superfamily. Pi family.