Fructose and glucose phosphorylating enzyme (PubMed:7610198). May be involved in the phosphorylation of glucose during the export from mitochondrion to cytosol (PubMed:16920781). Acts as sugar sensor which may regulate sugar-dependent gene repression or activation (PubMed:9014361, PubMed:12690200, PubMed:26528314). Mediates the effects of sugar on plant growth and development independently of its catalytic activity or the sugar metabolism (PubMed:9014361, PubMed:12690200). May regulate the execution of program cell death in plant cells (PubMed:16920781). Promotes roots and leaves growth (PubMed:26528314). ATP + D-hexose = ADP + D-hexose 6-phosphate + H(+) ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+) ATP + D-glucose = ADP + D-glucose 6-phosphate + H(+) Measured in yeast lacking glucose and hexose kinase activity. Carbohydrate metabolism; hexose metabolism. Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4. Interacts with RPT5B in nucleus. Interacts with RHIP1 (PubMed:26528314). Highly expressed in flowers and siliques, at intermediate levels in roots and stems, and at lower levels in rosette and cauline leaves. Plants display a glucose-insensitive phenotype which allows them to grow on high glucose concentration medium (>6% glucose) (PubMed:12690200, PubMed:26528314). Dwarf plants with reduced roots and leaves growth (PubMed:26528314). Belongs to the hexokinase family. Truncated N-terminus.