Direct regulator of SIRT1. Enhances SIRT1-mediated deacetylation of p53/TP53, thereby participating in inhibition of p53/TP53-mediated transcriptional activity (By similarity). Interacts with SIRT1 (By similarity). Interacts with RPS19. Widely expressed with higher levels in submaxillary gland and epididymis. Citrullinated by PADI4. Belongs to the AROS family.