Acts as a 'third messenger' substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium (By similarity). Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation. Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions. Belongs to the neurogranin family.