Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. Expressed by the venom duct. The cysteine framework is I (CC-C-C). Alpha4/3 pattern. Belongs to the conotoxin A superfamily. Has the same mature sequence than RgIA (AC P0C1D0). RgIA could therefore be the precursor of Reg1e, except that RgIA does not have the C-terminal Gly residue required for C-terminal amidation of Reg1e.