Component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. ATP + H2O = ADP + H(+) + phosphate Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex (PubMed:11003653). Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression (PubMed:17938210). Interacts with ZGPAT; the interaction is direct. Interacts with BCL6, BRD4 and PCNT. Interacts directly with IKFZ1 in the NuRD complex. Interacts with TRIM27. Part of a complex containing ATR and HDAC2. Interacts with HDAC2; the interaction is direct (By similarity). Interacts with SETX (By similarity). Interacts with HDAC1 (By similarity). Interacts with the ISWI chromatin remodeling complex component SMARCA5; the interaction is direct (By similarity). Interacts with the cohesin complex component RAD21; the interaction is direct (By similarity). Does not interact with PWWP2A and PWWP2B (PubMed:30228260, PubMed:30327463). Associates with centrosomes in interphase. Belongs to the SNF2/RAD54 helicase family.