Catalyzes the reduction of PGD(2) and PGH(2) to PGF(2 alpha) and a stereoisomer, respectively. It has a broad substrate specificity and reduces also other carbonyl compounds. NADP(+) + prostaglandin F2alpha = H(+) + NADPH + prostaglandin D2 Lipid metabolism; prostaglandin biosynthesis. Monomer. Belongs to the aldo/keto reductase family.