Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (PubMed:29453251). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated through the GPCR FPR2 (By similarity). Acts as a adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (PubMed:29453251). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (PubMed:29453251). Expressed in the epididymal adipose tissue, in aortic adventitial fibroblasts and low expression in vascular smooth muscle cells (at protein level) (PubMed:29453251). Expressed in the central nervous system, highly expressed in the hypothalamic paraventricular nucleus (PubMed:29453251). Repressed in adipocytes after stimulation with Tnfa, Il6 and Ins1 (PubMed:29453251). Specifically down-regulated in the hypothalamic paraventricular nucleus following water deprivation (PubMed:29453251). Belongs to the TAFA family.