Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor (PubMed:1840701). Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:8662698). Interacts with IL8 (PubMed:1840701). Interacts with GNAI2 (PubMed:8662698). Belongs to the G-protein coupled receptor 1 family. CXC chemokine receptors entry