Oxidoreductase that binds mammalian estrogens with high affinity. A + H(+) + NADPH = AH2 + NADP(+) Induced by estrogen (17beta-estradiol). Decreases phagocytosis of the fungus by host cells (PubMed:34986357). Increases expression of GPD2 (PubMed:34986357). Belongs to the NADH:flavin oxidoreductase/NADH oxidase family.