Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules. Component of the nexin-dynein regulatory complex (N-DRC). Morpholino knockdown of the protein causes strong ciliopathy phenotypes, including pronephric cysts, axis curvature, left-right asymmetry defects and hydrocephalus. Cilia length and number appear normal, but cilia are dyskinetic. Belongs to the DRC2 family.