Dual specificity enzyme that catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs. uridine(32) in tRNA = pseudouridine(32) in tRNA uridine(746) in 23S rRNA = pseudouridine(746) in 23S rRNA Belongs to the pseudouridine synthase RluA family.