Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337). May play a role in the assembly of N-DRC (PubMed:23427265). Component of the nexin-dynein regulatory complex (N-DRC), composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8, DRC9, DRC10 and DRC11 (PubMed:23427265, PubMed:25411337). Interacts with DRC1, DRC2, DRC3, DRC4, DRC7 and DRC11 (PubMed:25411337). Detected along the length of the sperm flagellum. Defects in DRC5 give the sup-pf4 phenotype characterized by disruption of the assembly of several other N-DRC subunits. Belongs to the DRC5 family.