Has no detectable kinase activity in vitro. Interacts with calmodulin, in the presence of calcium. Predominantly observed in association with the plasma membrane of soma and in neurites, both axons and dendrites. May be associated with vesicular structures. Expressed in brain and weakly in eye. Not detected in liver, kidney, spleen, thymus, bladder, aorta, lung, intestine, esophagus, stomach, skeletal muscle, heart, diaphragm, uterus, tail skin, submaxillary gland, prostate, ear, epididymis, placenta, pancreas, ovary, testis, adrenal gland, parathyroid gland, thyroid gland, pineal gland, pituitary and sciatic nerve. In adult hippocampus, predominantly expressed in caudate nucleus, cortex, hypothalamus, olfactory bulb, and midbrain and faintly in pons, brainstem and spinal cord. Expressed from day 16 dpc, but accumulation was primarily postnatal with maximal steady state levels reached at postnatal day 10. The protein kinase domain is predicted to be catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.