Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia (By similarity). a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate Activated by ADP. Belongs to the 5'-nucleotidase type 3 family.