Metabolizes arachidonic acid mainly to 12-hydroxyeicosatetraenoic acid (HETE). an organic molecule + O2 + reduced [NADPH--hemoprotein reductase] = an alcohol + H(+) + H2O + oxidized [NADPH--hemoprotein reductase] Expressed in liver. P450 can be induced to high levels in liver and other tissues by various foreign compounds, including drugs, pesticides, and carcinogens. Belongs to the cytochrome P450 family.