Iron-sulfur cluster scaffold protein which can assemble [4Fe-4S] clusters and deliver them to target proteins. Monomer and homohexamer; the apo-NFU1 is a monomer, while the holo-NFU1 is a hexamer composed of a trimer of dimer that is probably linked by some 4Fe-4S cluster (PubMed:27818104). Interacts with HIRA and EPM2A/laforin (PubMed:12915448). Interacts with BOLA3 (PubMed:27532772). Interacts with HSPA9 (PubMed:26702583). Ubiquitous. Expression in adult lung is weak compared to fetal lung. Expressed in embryo and adult. The disease is caused by variants affecting the gene represented in this entry. Belongs to the NifU family. Truncated N-terminus. Truncated N-terminus.