Receptor on natural killer (NK) cells for some HLA-C alleles such as w6. Does not inhibit the activity of NK cells. Interacts with the adapter protein TYROBP/DAP12; the interaction enhances KIR2DS1 stability at the cell surface. Expressed by NK cells. Belongs to the immunoglobulin superfamily. The KIR2DS1 gene is not directly represented on the GRCh38 primary reference genome assembly but on alternate loci of that assembly.