Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53 (By similarity). Homodimer. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29 and VPS35. Interacts with KRT17. Interacts with GAB2 and SAMSN1 (By similarity). Interacts with SRPK2 (By similarity). Interacts with COPS6 (By similarity). Interacts with COP1; this interaction leads to proteasomal degradation (By similarity). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (By similarity). Interacts with PI4KB (By similarity). Interacts with SLITRK1 (By similarity). Interacts with LRRK2; this interaction is dependent on LRRK2 phosphorylation (By similarity). May be secreted by a non-classical secretory pathway. Ubiquitinated. Ubiquitination by RFFL induces proteasomal degradation and indirectly regulates p53/TP53 activation (By similarity). 14-3-3 proteins have been shown to be PKC activators, but this effect could be non-specific and only due to the acidic nature of the protein. Belongs to the 14-3-3 family.