May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (By similarity). Interacts with RNF167. Localized at the apical membrane surface of renal proximal tubules. Expressed at high levels in fetal and adult kidney and liver, and extraembryonic membranes (yolk sac). Expressed at moderate levels in intestine, heart, lung and testis. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.