Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity). a ribonucleoside 5'-phosphate + H2O = a ribonucleoside + phosphate Activated by ADP. Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liver and lung. Belongs to the 5'-nucleotidase type 3 family.