Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (PubMed:22633490). Involved in coenzyme Q (CoQ) biosynthesis, catalyzing the last step in the tyrosine to 4-hydroxybenzoate (4-HB) pathway. Oxidizes 4-hydroxybenzaldehyde (4-Hbz) to 4-HB, the aromatic precursor for coenzyme Q (PubMed:27693056, PubMed:27669165). an aldehyde + H2O + NAD(+) = a carboxylate + 2 H(+) + NADH 2 H(+) + hexadecanoate + NADH = H2O + hexadecanal + NAD(+) 4-hydroxybenzaldehyde + H2O + NAD(+) = 4-hydroxybenzoate + 2 H(+) + NADH Results in coenzyme Q deficiency. Present with 2930 molecules/cell in log phase SD medium. Belongs to the aldehyde dehydrogenase family.