Has high NADPH-dependent quinone reductase activity with a preference for quinones with hydrophobic substituents. Reduces also CrO4(2-) and Fe(3+). Somewhat active with NADH. May be involved in response to oxidative stress caused by arsenic. a quinone + H(+) + NADH = a quinol + NAD(+) a quinone + H(+) + NADPH = a quinol + NADP(+) Inhibited by NADP(+) and weakly by dicoumarol. E(0) is -181 +/- 2 mV at pH 7.5. Homotetramer. By arsenite and arsenate ions, but not by CrO4(2-) or Fe(3+). No visible phenotype (PubMed:12949088). Sensitive to the oxidizing agent menadione in the presence of arsenite ion (PubMed:22304305). Decreased arsenic and chromium accumulation (PubMed:24861149). Belongs to the ArsH family.