Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH (By similarity). Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with SLC50A1; the interaction probably occurs intracellularly and depends on TRPV2 N-glycosylation. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal cord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). N-glycosylated. Phosphorylated by PKA. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.