Antimicrobial peptide with high activity against Gram-positive bacteria, low activity against Gram-negative bacteria, and moderate activity against fungi (PubMed:20451254, PubMed:23967105). Acts on bacterial biofilms (S.aureus) with the same potency than on bacteria (PubMed:20451254). Acts by causing bacterial membrane disruption inducing leakage of the intracellular content followed by cell death (PubMed:23967105). It adopts an alpha-helical amphipathic structure in membrane environments (PubMed:23967105). Also shows highly potent antiparasitic activity against Leishmania species (PubMed:23967105). Shows low hemolytic activity on horse and human erythrocytes (LC(50)=39 uM) (PubMed:20451254, PubMed:23967105). Is also active on human monocytes (IC(50)=23 uM) (PubMed:23967105). Optimum pH is <7. Is active against E.coli ATCC25922 at pH 5 (MIC=12.5 uM), whereas is almost not active at pH 7 (MIC=70 uM). Forms a helical membrane channel in the target. Expressed by the skin glands. Belongs to the frog skin active peptide (FSAP) family. Phylloseptin subfamily.