Virulence effector that is indispensable for endoplasmic reticulum (ER)-mediated remodeling of the Legionella pneumophila-containing vacuole (LCV) and lysosomal evasion (PubMed:33563829). Essential for intracellular replication in human monocyte-derived macrophages (hMDMs) and amoebae, as well as for intrapulmonary proliferation in mice (PubMed:33563829). Homotrimer. Translocated into the host cell via the type IV secretion system (T4SS) (Probable). During infection, localizes to the poles of the LCV membrane (PubMed:33563829). Contains a C-terminal transmembrane helix, three copies of tyrosine-based sorting motifs, and an NPxY eukaryotic motif, which binds phosphotyrosine-binding domains present on signaling and adapter eukaryotic proteins (PubMed:33563829). The NPxY eukaryotic motif is essential for ER-mediated remodeling and lysosomal evasion by the LCV (PubMed:33563829). The null mutant fails to remodel the LCV with endoplasmic reticulum (ER)-derived vesicles and is trafficked to the lysosomes where it is degraded (PubMed:33563829). Mutant is defective for intracellular growth in hMDMs, amoeba and for intrapulmonary proliferation in mice (PubMed:33563829).