Involved in the cross-linking of microtubules and microfilaments (By similarity). Regulates microtubule dynamics and stability by interacting with microtubule plus-end tracking proteins, such as MAPRE1, to regulate microtubule growth along actin stress fibers (By similarity). Enhances ADORA2-mediated adenylyl cyclase activation by acting as a scaffold to recruit trimeric G-protein complexes to ADORA2A (PubMed:23994616). Regulates ciliary orientation and performance in cells located in the airway (PubMed:30665704). Interacts with ADORA2A (via its cytoplasmic C-terminal domain) (PubMed:23994616). Interacts with GNAS, GNAL, GNAQ, and GNA13 (PubMed:23994616). Interacts with MAPRE1 (PubMed:24706950). Colocalizes with ADORA2A at neuronal processes (By similarity). Colocalizes with and tracks the tips of microtubule plus ends (By similarity). Expressed in tracheal epithelial cells (at protein level). Knockout mice exhibit a high rate of neonatal death (PubMed:30665704). Mice that survive show signs of hydrocephalus at postnatal days 14 and 21, along with mucus accumulation in multiple sinuses, and remodeling of the nasal cavity (PubMed:30665704). Conditional knockout in tracheal cells lead to isolated cases of hydrocephalus, as well as chronic rhinosinusitis and accumulation of mucus in the nasal cavity, which is caused by impaired mucociliary clearance (PubMed:30665704). Belongs to the GAS2 family.