May only reduce GSH-thiol disulfides, but not protein disulfides (Probable). Participates probably to the maturation of iron-sulfur proteins and to the regulation of the redox state of the BOLA proteins. The GRXS17-BOLA2 heterodimer binds a labile, oxygen sensitive iron-sulfur cluster (PubMed:24714563). [2Fe-2S]-bridged holo-homodimer (By similarity). Interacts in vitro with SUFE1, BOLA1, BOLA2 and BOLA4 (PubMed:24203231). Interacts in vivo only with BOLA2 (PubMed:24203231, PubMed:24714563). Interacts with RGLG3 and RGLG4 (PubMed:27497447). The Glutaredoxin 2 domain is sufficient for interaction with all BOLA. Ubiquitinated at Lys-154. Polyubiquitinated by RGLG3 and RGLG4. Polyubiquitination of GRXS17 leads to its degradation by the proteasome. Belongs to the glutaredoxin family. CGFS subfamily.