Component of the AP2-containing clathrin coat that may regulate clathrin-dependent trafficking at plasma membrane, TGN and endosomal system (Probable). A possible serine/threonine-protein kinase toward the beta2-subunit of the plasma membrane adapter complex AP2 and other proteins in presence of poly-L-lysine has not been confirmed (PubMed:15809293, PubMed:16914521). By regulating the expression of excitatory receptors at synapses, plays an essential role in neuronal function and signaling and in brain development (By similarity). Interacts with clathrin and AP2B1; the interaction mediates the association with the AP-2 complex. Colocalizes to the trans-Golgi network (TGN) and to endosomal membranes with clathrin, transferrin and plasma membrane adapter AP1 and AP3 complexes. Could autophosphorylate in presence of poly-L-lysine. The disease is caused by variants affecting the gene represented in this entry. Belongs to the protein kinase superfamily. Truncated N-terminus. Truncated N-terminus. Truncated N-terminus.