Involved in ubiquitination and subsequent proteasomal degradation of target proteins. Together with CUL1, RBX1 and a F-box protein, it forms a SCF E3 ubiquitin ligase complex. The functional specificity of this complex depends on the type of F-box protein. In the SCF complex, it serves as an adapter that links the F-box protein to CUL1 (By similarity). Probably implicated in incompatibility response after hybridization. Protein modification; protein ubiquitination. Part of a SCF (SKP1-cullin-F-box) protein ligase complex (By similarity). Interacts with CPR1/CPR30. Mainly detected in the siliques. Repressed by MEA and the polycomb repressive complex (PRC). This protein was called 'Meidos' in memory of one of the murdered sons of the mythological 'Medea', as MEIDOS is repressed by MEDEA. Belongs to the SKP1 family.