Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (sftpc). Interacts with DNAJB9, DNAJC10 and mutated SFTPC (By similarity). Interacts with SYNE2 during the early establishment of cell polarity (By similarity). Part of the tectonic-like complex (also named B9 complex) (PubMed:21725307). Interacts (via C-terminus) with FLNA (By similarity). Interacts with TMEM218 (By similarity). Localizes at the transition zone, a region between the basal body and the ciliary axoneme. A spontaneous deletion of TMEM67 cause the bilateral polycystic kidneys (bpck) phenotype, a disease mimicking human Meckel-Gruber syndrome 3. Homozygous bpck/bpck mice typically manifest bilateral nephropathy with swollen abdomens resulting from grossly enlarged polycystic kidneys and die by 3 week of age. Some mice also develop hydrocephalus, usually detectable within a few days of birth (PubMed:19211713). Additionally, bpck/bpck mice exhibit retinal degeneration and tissue disorganization in the eye, and cochlear defects (PubMed:23393159). Mice survive to birth with no overt morphological abnormalities. However, these mice died soon after birth. Truncated N-terminus. Extended N-terminus.