Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells (PubMed:12681493). Homodimer (By similarity). Interacts with FYN (By similarity). Interacts with PTPRC (By similarity). Interacts with GRB2 when phosphorylated on Tyr-267 (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability (By similarity). Interacts with FYB1, which is required for SKAP2 protein stability (By similarity). Part of a complex consisting of SKAP1, FYB1 and CLNK (PubMed:12681493). Interacts with RASGRP1 (By similarity). Interacts with FYB2 (By similarity). Upon T-cell stimulation, translocates to lipid rafts at the cell membrane. Expressed in mast cells (at protein level). The SH3 domain interacts with FYB1. Phosphorylated on tyrosines. Phosphorylation by FYN on Tyr-267 is required for GRB2 interaction (By similarity). Phosphorylation by FYN on Tyr-290 abolishes interaction with FYB1. Tyr-236 is dephosphorylated by PTPRC (By similarity). Belongs to the SKAP family.