Histones H1 are necessary for the condensation of nucleosome chains into higher-order structures. Oncorhyncin II has antibacterial activity against Gram-positive and Gram-negative bacteria at submicromolar concentrations. Potentially important role in mucosal defense. Thermostable up to 80 degrees Celsius. Oncorhyncin II is expressed in skin. Belongs to the histone H1/H5 family.