Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). Binds to dimeric RII-alpha regulatory subunit of PKC. May be part of the cortical cytoskeleton. Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. Activated by lysophosphatidylcholine (lysoPC). Polybasic regions located between residues 266 and 557 are involved in binding PKC. Antibodies against the C-terminal of gravin can be produced by patients with myasthenia gravis (MG). Extended N-terminus.