Has single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity suggesting a role in nuclear processes such as recombination and transcription (By similarity). Proposed core component of the chromatin remodeling INO80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding (By similarity). ATP + H2O = ADP + H(+) + phosphate Forms homohexameric rings (By similarity). Can form a dodecamer with ruvbl2 made of two stacked hexameric rings (By similarity). Is a component of the RNA polymerase II holoenzyme complex. Component of the chromatin-remodeling Ino80 complex (By similarity). Component of some MLL1/MLL complex (By similarity). Strong expression in neural crest cells and in later stages in different gastrointestinal organs. Belongs to the RuvB family.