Receptor for netrin required for axon guidance (PubMed:22685302, PubMed:10399920). Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (PubMed:10399920, PubMed:22685302). NTN1/Netrin-1 binding might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion (PubMed:28483977). Axon repulsion in growth cones may also be caused by its association with DCC that may trigger signaling for repulsion (PubMed:10399920). Might also collaborate with DSCAM in NTN1-mediated axon repulsion independently of DCC (PubMed:22685302). Also involved in corticospinal tract axon guidance independently of DCC (PubMed:9126743, PubMed:9389662, PubMed:12451134). Involved in dorsal root ganglion axon projection towards the spinal cord (By similarity). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (By similarity). Interacts with DCC (via cytoplasmic domain) (PubMed:10399920, PubMed:11533026). Interacts (tyrosine phosphorylated form) with PTPN11 (PubMed:11533026). Interacts (via extracellular domain) with FLRT3 (via extracellular domain) (PubMed:22405201). Interacts (via Ig-like C2-type domain) with DSCAM (via extracellular domain) (PubMed:22685302). Interacts (via death domain) with DAPK1 (By similarity). Interacts (via cytoplasmic domain) with TUBB3; this interaction is decreased by NTN1/Netrin-1 (PubMed:28483977). Expressed in cortical and cerebellar neurons, including cells of the external and internal granular layer and of the Purkinje cell layer (at protein level) (PubMed:22685302, PubMed:28483977). Mainly expressed in regions of differentiating neurons (PubMed:9126743). Highly expressed in brain and lung (PubMed:9126743, PubMed:9389662). Expressed in the cerebellum and the neurons of the hippocampus, with enrichment in neurons of the CA3 hippocampal pyramidal layer (PubMed:25419706). Weakly expressed in testis, ovary, spleen, thymus and bladder (PubMed:9126743). Expressed at very low level in kidney, intestine and salivary gland (PubMed:9126743). Detected at 15 dpc in the cortex and cerebellum and at postnatal day 2 and 4 in the cerebellum (at protein level). Phosphorylated on different cytoplasmic tyrosine residues (PubMed:11533026). Phosphorylation of Tyr-568 leads to an interaction with PTPN11 phosphatase, suggesting that its activity is regulated by phosphorylation/dephosphorylation (PubMed:11533026). Tyrosine phosphorylation is netrin-dependent (PubMed:11533026, PubMed:22685302). Proteolytically cleaved by caspases during apoptosis. The cleavage does not take place when the receptor is associated with netrin ligand. Its cleavage by caspases is required to induce apoptosis. Defects in Unc5c are the cause of rostral cerebellar malformation (Rcm). Rcm is characterized by cerebellar and midbrain defects, apparently as a result of abnormal neuronal migration. Belongs to the unc-5 family.