Positively regulates Ras-mediated pathways. Acts downstream or parallel to Raf, but upstream of nuclear factors in Ras signaling. Three mutants have been isolated, that suppress the rough eye phenotype caused by mutated Ras1 (sev-Ras1 v12). Inhibits yki activity by restricting its nuclear localization. Together with pav, has a role in the inhibition of microtubule sliding during neurite outgrowth (PubMed:32022690). Homodimer (By similarity). Interacts with phosphorylated yki (PubMed:18256197, PubMed:19900439). Interacts with pav (when serine phosphorylated); the interaction is necessary for association of the complex pav-14-3-3epsilon complex to the microtubules, thereby inhibiting microtubule sliding (PubMed:32022690). Additional isoforms may exist. Belongs to the 14-3-3 family.