Plays a role in cytoplasmic pre-assembly of axonemal dynein. Interacts with HSPA1A/B and HSP90AA1 (By similarity). Interacts with DNAAF2 and DNAAF4 (PubMed:28041644). Interacts wuth DNAI2 (PubMed:28176794). Localized to the cytoplasm of spermatogenic cells. Expressed in testis, small intestine, prostate, adrenal gland, spleen, lung, bladder, breast and ovary. Expressed in ciliated epithelial cells (PubMed:28176794). The disease is caused by variants affecting the gene represented in this entry. Belongs to the PIH1 family.