This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium (By similarity). Transports calcium to the vacuole and participates in the control of cytosolic free calcium (PubMed:23895559). ATP + Ca(2+)(in) + H2O = ADP + Ca(2+)(out) + H(+) + phosphate Increases cytosolic free calcium level (PubMed:23895559). Resistance to cadmium (PubMed:23895559). Decreases cell population growth in serum (PubMed:29113016). Sensitive to calcium (PubMed:23895559). Abnormal level of calcineurin-mediated signaling pathway gene RNA, transepithelial migration gene RNA, and antioxidant gene RNA (PubMed:29113016). Decreases VCX1 RNA level and increases ECA1 RNA level during cellular response to calcium (PubMed:23895559). Decreases urease activity (PubMed:29113016). Avirulence in a mouse systemic model of infection; decreases lung fungal burden and abolishes brain fungal burden (PubMed:29113016). Decreases virulence in a mouse intranasal inhalation infection model; decreases lung fungal burden and abolishes brain fungal burden (PubMed:23895559). Severely decreases transepithelial migration through the host blood-brain barrier (PubMed:29113016). Increases susceptibility to phagocytosis by macrophages (PubMed:29113016). Phenotypes enhanced in a double knockout with VCX1 (PubMed:23895559). Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.