Part of the ESX-1 specialized secretion system, which delivers several virulence factors to host cells during infection, including the key virulence factors EsxA (ESAT-6) and EsxB (CFP-10) (PubMed:18974091, PubMed:16368961). EccA1 exhibits ATPase activity and may provide energy for the export of ESX-1 substrates (PubMed:18974091). Part of the ESX-1 / type VII secretion system (T7SS), which is composed of cytosolic and membrane components (PubMed:16368961, PubMed:19876390). Homohexamer (PubMed:18974091). Interacts with Ppe68, EspF and the C-terminus of EspC (PubMed:17433643, PubMed:19682254). The N-terminal region is compact and probably functions to regulate the ATPase activity and the oligomerization. The C-terminal region contains the ATPase activity and the oligomerization domain. Disruption abolishes EsxA and EsxB secretion, but not their expression. It results in a lack of antigen specific immunogenicity and leads to attenuated virulence. Was identified as a high-confidence drug target. Belongs to the CbxX/CfxQ family.