May serve as a scaffold protein for MADD and RAB3GA on synaptic vesicles of neuronal and endocrine homeostatic processes (By similarity). Plays a role in the brain as a key controller of neuronal and endocrine homeostatic processes (PubMed:25248098). Interacts with MADD and RAB3GAP. The external layer of the inferior boundary for the hypothalamus part of the human brain (the so called median eminence (ME)) displayed a punctate pattern of expression; expression also observed in the cell bodies lining the third ventricle, in the long processes extending from these cell bodies toward the external layer of the ME, in small clear vesicles, and in large dense core vesicles. Expressed in the brain and pituitary gland. Detected in the hippocampus, dentate gyrus, hypothalamus, pyriform cortex and the granular and molecular layers of the cerebellum of adult animals. In the hypothalamus, expression is observed in the arcuate nucleus, the ME, the organum vasculosum of the lamina terminalis, and the subfornical organ, the subcommissural organ, and the suprachiasmatic nucleus. Both tanycytes and hypothalamic neurosecretory neurons express the protein (PubMed:25248098). Expressed in the inner and outer hair cells as well as in the spiral ganglion neurons (PubMed:27657680). Expressed in insulin-secreting cells of the islets of Langerhans in the pancreas (PubMed:25248098). Conditional heterozygous deletion of the gene in neurons causes delayed puberty as well as very low fertility; the reproductive phenotype is associated with a reduced number of GnRH neurons in the hypothalamus of adult mice. Animals with a homozygous deletion of the gene die during embryonic development.