Depressant insect toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently to sodium channels (Nav) and block action potentials, primarily by depolarizing the axonal membrane and suppressing the sodium current (By similarity). Expressed by the venom gland. Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily.