May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based cytoskeletons. Homodimer or oligomer (Probable). Interacts with CD2AP and SH3BP1; probably part of a complex at cell junctions (By similarity). Localizes to the apical junction complex composed of tight and adherens junctions. In the liver and kidney, it is also found along non-junctional actin filament bundles in addition to the apical junction. Widely expressed. Highly expressed in the kidney and lung. The head region is responsible for both junction and actin filament-based distribution. Belongs to the cingulin family.