Hydrolase that specifically degrades the potent antimicrobial compound 2,4-diacetylphloroglucinol (DAPG) to equimolar amounts of mildly toxic monoacetylphloroglucinol (MAPG) and acetate. 2,4-diacetylphloroglucinol + H2O = 2-acetylphloroglucinol + acetate Specifically and significantly activated by CoCl(2). Competitively inhibited by MAPG, but not by 2-hydroxy- and 4-hydroxyacetophenone. kcat is 5.8 sec(-1). Optimum pH is about 6.0. Homodimer. Belongs to the DAPG/phloretin hydrolase family.