E3 ubiquitin-protein ligase mediating 'Lys-63'-linked polyubiquitination of RRAGA in response to amino acid starvation. Thereby, regulates mTORC1 signaling and plays a role in the cellular response to amino acid availability (PubMed:25936802). Also mediates 'Lys-48'-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed (By similarity). S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine. Protein modification; protein ubiquitination. Interacts with RRAGA (inactive GDP-bound form); stimulated by amino acid starvation (By similarity). Interacts with SEC16A (PubMed:29300766). Ubiquitinated. Autoubiquitinated in vitro, leading to its degradation by the proteasome. Mice lacking Rnf152 do not show overt embryonic development defect. Belongs to the RNF152 family.