Catalyzes the hydrolysis of pseudosubstrates such as p-nitrocatechol sulfate and p-nitrophenyl sulfate (PubMed:23986440). Catalyzes the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate (PubMed:28055182). Acts selectively on 2-sulfoglucuronate and lacks activity against 2-sulfoiduronate (PubMed:28055182). an aryl sulfate + H2O = a phenol + H(+) + sulfate Hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate. Binds 1 Ca(2+) ion per subunit. Optimum pH is 4.6. Expressed at high levels in the placenta and pancreas (PubMed:23986440). Expressed at intermediate levels in the lung, brain, heart, liver and kidney and at low levels in the muscle (PubMed:23986440). The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. The 75-kDa precursor undergoes proteolytic processing to yield a 23 kDa form. N-glycosylated with both high mannose and complex type sugars. Belongs to the sulfatase family. Extended N-terminus.