Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles (By similarity). Prevents dopaminergic CEP neuron degeneration in response to Mn(2+) (PubMed:23721876). glutathione + RX = a halide anion + an S-substituted glutathione + H(+) Homodimer. Expressed in dopaminergic (DA) neuron (at protein levels). By manganese. RNAi-mediated knockdown causes an increase in Mn(2+)-mediated dopaminergic CEP neuron degeneration. Belongs to the GST superfamily. Pi family.