May play a role in embryonic and postnatal development of the brain. Increased resistance to cell death induced by serum starvation in cultured cells. Regulates cAMP-induced GFAP gene expression via STAT3 phosphorylation. Interacts with HSPA5/GRP78. Expressed in the brain in neuronal cells of the hypothalamus, thalamus, cerebral cortex, amygdala, and cerebellum. Detected in the brain at E12 with increasing level reaching a peak within 2 weeks after birth. Belongs to the TMEM132 family.