Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:29167384). Component of the nexin-dynein regulatory complex (N-DRC), composed of at least DRC1, DRC2, DRC3, DRC4, DRC5, DRC6, DRC7, DRC8, DRC9, DRC10 and DRC11 (PubMed:23427265, PubMed:25411337, PubMed:29167384). Interacts with DRC4 and DRC5 (PubMed:23427265). Asymmetrically dimethylated at Arg-96 and Arg-142 during flagellum resorption. Probably methylated by PRMT1. Defects in DRC2 give the ida6 and sup-pf5 phenotypes characterized by reduced swimming speed, disruption of the assembly of several other N-DRC subunits and destabilization of the assembly of several closely associated structures such as the inner dynein arms and the radial spokes. Belongs to the DRC2 family.