Selectively cleaves the beta-phosphate at the 5-position of soluble inositol pyrophosphates. Converts 5-diphosphoinositol tetrakisphosphate (5-PP-InsP(4)) into inositol pentakisphosphate (InsP(5)), 5-diphosphoinositol pentakisphosphate (5-PP-IP(5) or 5-InsP(7)) into inositol hexakisphosphate (IP(6) or InsP(6)), and 1,5-bisdiphosphoinositol tetrakisphosphate (1,5-PP-IP(5) or InsP(8)) into 1-diphosphoinositol pentakisphosphate (1-PP-IP(5) or 1-InsP(7)) (PubMed:26828065, PubMed:29540476). Modulates inositol pyrophosphate metabolism that may have an influence in stress response (PubMed:26828065). Plays a role in actin filament organization and endocytosis (PubMed:15020461). Functions as a prion suppressing factor possibly due to its phosphatase activity against inositol pyrophosphates, which are signal transduction molecules involved in prion propagation (PubMed:28923943). 5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + H2O = 1D-myo-inositol hexakisphosphate + H(+) + phosphate 5-diphospho-1D-myo-inositol 1,3,4,6-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + H(+) + phosphate 3,5-bis(diphospho)-1D-myo-inositol 1,2,4,6-tetrakisphosphate + H2O = 3-diphospho-1D-myo-inositol 1,2,4,5,6-pentakisphosphate + 2 H(+) + phosphate kcat is 0.0025 sec(-1) with 5-diphosphoinositol pentakisphosphate as substrate (PubMed:26828065). kcat is 1.31 sec(-1) with 5-diphosphoinositol pentakisphosphate as substrate, 0.77 sec(-1) with 5-diphosphoinositol tetrakisphosphate as substrate, and 0.63 sec(-1) with 1,5-bisdiphosphoinositol tetrakisphosphate as substrate (PubMed:29540476). Optimum pH is 6. Optimum temperature is 37 degrees Celsius. Monomer. Present with 4070 molecules/cell in log phase SD medium. Belongs to the protein-tyrosine phosphatase family.