Required for renal function. Homooligomer (By similarity). Central component of a complex containing at least ANKS6, INVS, NEK8 and NPHP3 (By similarity). ANKS6 may organize complex assembly by linking INVS and NPHP3 to NEK8 and INVS may target the complex to the proximal ciliary axoneme (By similarity). Interacts (via SAM domain) with BICC1 (via KH domains) in an RNA-dependent manner (By similarity). Interacts (via SAM domain) with ANKS3 (via SAM domain) (PubMed:25671767, PubMed:26327442). Localizes to the proximal region of the primary cilium in the presence of INVS. Expressed in kidney (at protein level). The ankyrin repeats are necessary and sufficient for NEK8-binding. Hydroxylated at Asn-129, most probably by HIF1AN. This hydroxylation results in decreased NEK8-binding. Truncated N-terminus.