Probable hydrolase that plays an aggravative role in the development of cardiac hypertrophy via activation of the NF-kappa-B signaling pathway. Isoform 2 interacts with the sarcomeric proteins, MRLC2, MYOM1 and ENO3. Expressed in many discrete areas of the brain. By Hepatitis C virus core protein. Mice overexpressing Pnkd infused with angiotensin II develop greater cardiac hypertrophy as well as increased cardiac inflammation and fibrosis, compared with angiotensin II-infused normal mice. In these mice, Pnkd overexpression promote nuclear factor kappa B activation. Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.