Plays important roles in regulating apoptosis, metabolism and mitochondrial dynamics. MTCH2 acts as a receptor for the truncated form of pro-apoptotic BH3-interacting domain death agonist (p15 BID) and has therefore a critical function in apoptosis. Plays a critical role in controlling the quiescence/cycling of hematopoietic stem cells (HSCs). Acts as a regulator of mitochondrial fusion, essential for the naive-to-primed interconversion of embryonic stem cells (ESCs). Acts as a regulator of lipid homeostasis and has a regulatory role in adipocyte differentiation and biology. Interacts with p15BID. Belongs to the mitochondrial carrier (TC 2.A.29) family.