Nuclear lamina-associated inner nuclear membrane protein that is involved in cell division, nuclear structure organization, maintenance of nuclear envelope integrity and nuclear envelope reformation after mitosis (PubMed:11870211, PubMed:12684533, PubMed:22171324). Involved in chromosome segregation and cell division, probably via its interaction with the nuclear intermediate filament protein lmn-1, the main component of nuclear lamina (PubMed:11870211, PubMed:12684533). Required to organize the distribution of lmn-1, nuclear pore complexes (NPCs) and chromatin in mitotically active cells (PubMed:22171324). Together with lem-2, plays a role in baf-1 enrichment at the nuclear envelope in anaphase (PubMed:12684533). Together with lem-2, involved in muscle cell attachment to hypodermal cells, as well as muscle cell location and sarcomere organization (PubMed:22171324). May play a role in radiation-induced DNA damage repair response (PubMed:22383942). May repress binding of transcription factor pha-4 with target sequences in pharyngeal cells. Interacts with lmn-1 and baf-1. Lmn-1 and mel-28 are required for its localization to the nuclear envelope (PubMed:11870211, PubMed:16950114). Remains in the nuclear envelope until mid-late anaphase (PubMed:10982402). Recruited to the reforming nuclear envelope from telophase and throughout interphase (PubMed:25653391). Ubiquitous (PubMed:11870211, PubMed:25653391). Expressed in all cells, except in cells undergoing spermatogenesis (PubMed:11870211). High expression in hypodermis, neurons, pharyngeal muscle, body wall muscle and gonadal sheath (PubMed:25653391). Expressed throughout the development and in adults. Mild increase in embryonic lethality of progeny of X-ray-irradiated adults (PubMed:22383942). Slightly more spherical nuclei (PubMed:25653391). Simultaneous knockout of emr-1 and lem-2 leads to embryonic lethality, 8.5% shorter animals in larval stage L2, abnormal gonads and a developmental stop at late L2/early L3 (PubMed:22171324). Missing cell divisions in the postembryonic mesodermal lineage and failure to produce any of the differentiated M lineage cells (PubMed:22171324). Defects in the organization of chromatin, nuclear intermediate filaments, and nuclear pore complexes (NPCs), and defects in mitosis in cells that continue to divide after embryogenesis (PubMed:22171324). In the mitotic zone of the gonad, lmn-1 and NPCs are mislocalized and nuclei are misshaped (PubMed:22171324). Misshaped nuclei with large lmn-1 aggregates, clustered NPCs and condensed chromatin in somatic hypodermal cells (PubMed:22171324). Defects in motility, sarcomere organization, and muscle attachment to hypodermis (PubMed:22171324). Decreased motility and near paralysis at day 6 (PubMed:22171324). Disorganized thin and thick filaments of sarcomeres and abnormally positioned muscles at day 3 and 6 (PubMed:22171324). Decreased pumping rate of the pharynx (PubMed:22171324). RNAi-mediated knockdown causes an increase in the number of nuclei with pha-4 bound to the pax-1 promoter; observed in pharyngeal but not intestinal cells (PubMed:20714352). Simultaneous RNAi-mediated knockdown of lem-2 and emr-1 causes anaphase chromatin bridges and redistribution of baf-1 from the nuclear periphery to the segregating chromatin during anaphase (PubMed:12684533).