Membrane-cytoskeleton-associated protein that promotes the assembly of the spectrin-actin network. Plays a role in actin filament capping (PubMed:23836506). Binds to calmodulin. Heterodimer of an alpha and a gamma subunit. Additional isoforms seem to exist. Isoform 1 is ubiquitously expressed. Comprised of three regions: a N-terminal protease-resistant globular head region, a short connecting subdomain, and a protease-sensitive tail region. Sumoylated. The disease is caused by variants affecting the gene represented in this entry. Belongs to the aldolase class II family. Adducin subfamily.