Insecticidal to house crickets (PubMed:33597864). It induces an excitatory slow-onset impact that leads to irreversible spastic paralysis (PubMed:33597864). It also modifies human voltage-gated potassium channel Kv1.5/KCNA5 (PubMed:33597864). Most likely, it binds to the voltage-sensing domain of the channel, suggesting it does not block the pore but prevents its opening at physiological membrane potentials (PubMed:33597864). The recombinant peptide binds to the channel in an irreversible manner and slows down the hKv1.5 current activation kinetics (PubMed:33597864). It is not toxic to mice, when intracranially injected (at 0.5 ug/g mouse) (PubMed:33597864). Expressed by the venom gland. PD(50) is 0.05 ug/g (6.6 pmol/g) in house crickets (Acheta domesticus). LD(50) is <0.1 ug/g (<13.3 pmol/g) in house crickets (Acheta domesticus). This toxin represents a concentration of ~60 ug per mg of O.supermirabilis dry crude venom. Belongs to the neurotoxin 04 (omega-agtx) family. 01 (type I omega-agtx) subfamily.