Adapter protein which constitutively binds TBK1 and IKBKE playing a role in antiviral innate immunity. Homodimer. May form a heterodimer with NAP1. Interacts with TKB1 and IKBKE. Weakly interacts with DDX3X (PubMed:27980081). (Microbial infection) Interacts with vaccinia virus protein C6 (PubMed:21931555). Detected in leukocytes, lung, placenta, small intestine, liver, kidney, spleen, muscle, heart, brain and at low levels in thymus. Extended N-terminus.