Confers resistance to the different beta-lactams antibiotics (penicillin, cephalosporin and carbapenem) via the hydrolysis of the beta-lactam ring. a beta-lactam + H2O = a substituted beta-amino acid Binds 2 Zn(2+) ions per subunit. Inhibited by captopril stereoisomers, Hg(2+), Fe(2+), Cu(2+) and by chelating agents such as EDTA (PubMed:8141584, PubMed:26482303). This enzyme is not susceptible to inactivation by the beta-lactamase-blocking agents clavulanic acid or cloxacillin (PubMed:8141584). Monomer. Belongs to the metallo-beta-lactamase superfamily. Class-B beta-lactamase family.