Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, ARHGEF28 and TIAM2. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10 (By similarity). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with KSR1 (By similarity). Interacts with DENND1A (By similarity). Interacts with the phosphorylated (by AKT1) form of SRPK2. Interacts with TIAM2. Interacts with PI4KB, TBC1D22A and TBC1D22B.Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (By similarity). Interacts with ZFP36 (via phosphorylated form) (By similarity). Interacts with SLITRK1 (By similarity). Interacts with RIPOR2 (By similarity). Interacts with KLHL22; required for the nuclear localization of KLHL22 upon amino acid starvation (By similarity). Interacts with CRTC1 (By similarity). Interacts with CRTC2 (probably when phosphorylated at 'Ser-173') (By similarity). Interacts with CRTC3 (probably when phosphorylated at 'Ser-138' and/or 'Ser-249') (By similarity). Interacts with ATP2B1 and ATP2B3; this interaction inhibits calcium-transporting ATPase activity (By similarity). Interacts with MEFV (By similarity). Belongs to the 14-3-3 family.