On the cover: Merkel cell polyomavirus (MCV), a circular double-stranded DNA virus, is thought to be a causal factor underlying a lethal form of skin cancer known as Merkel cell carcinoma. Investigating healthy human skin, Schowalter and colleagues (this issue, pp. 509–515) isolate MCV and two previously unknown human polyomaviruses (HPyV6 and HPyV7). The results show that potentially pathogenic polyomavirus species reside on apparently healthy human skin. The cover depicts a maze design based on the phylogeny of polyomaviruses, showing the placement of MCV, HPyV6, and HPyV7 relative to other polyomaviruses.