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How does presynaptic α2- receptors and prostaglandins E series control sympathetic nervous activity?
How do prostaglandins E series stimulate the α2-adrenergic receptor?
Prostaglandins E series bind to specific receptor subtypes, which activate G proteins that modulate second messenger systems in the cell. This leads to the activation of protein kinases, which phosphorylate and desensitize the α2-adrenergic receptor, ultimately inhibiting norepinephrine release.