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How does Hutchinson–Gilford progeria syndrome affect/disrupt protein translation?
Can you explain how Hutchinson-Gilford progeria syndrome affects protein translation?
Certainly. Hutchinson-Gilford progeria syndrome is a rare genetic disorder that affects protein translation. It is caused by a mutation in the gene that encodes for lamin A, a protein that helps maintain the shape of the nucleus in cells. This mutation causes a change in the way the lamin A protein is produced, resulting in the production of an abnormal form of lamin A called progerin. Progerin disrupts the normal function of the cell, including protein translation.