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Are lymphomas monoclonal? If yes than how do they cause generalised lymphadenopathy if the neoplastic cell is present in only one node?
If the neoplastic cell is present in only one node, how do they cause generalised lymphadenopathy?
The neoplastic cell in the affected node can produce factors that stimulate the growth of other lymph nodes. Additionally, the immune response to the neoplastic cell can cause lymph nodes throughout the body to become enlarged.