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What is the function of DNA ligase in DNA replication?
How does DNA replication begin in the first place?
DNA replication begins with the unwinding of the double-stranded DNA molecule by the enzyme helicase. The resulting single-stranded DNA is then stabilized by single-stranded DNA-binding proteins. Primase then synthesizes a short RNA primer on the template strand, which is used as a starting point for DNA synthesis by DNA polymerase.