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How does presynaptic α2- receptors and prostaglandins E series control sympathetic nervous activity?
Can you tell me about how presynaptic α2- receptors and prostaglandins E series control sympathetic nervous activity?
Sure! Presynaptic α2-adrenergic receptors located on sympathetic nerve terminals mediate negative feedback regulation of norepinephrine release. Prostaglandins E series, acting locally, stimulate the α2-adrenergic receptor to inhibit norepinephrine release, thus decreasing sympathetic nerve activity.