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Can strong denaturants like guanidine hydrochloride help clear up protein aggregates from amyloid forming proteins?
I'm curious about the use of strong denaturants like guanidine hydrochloride in clearing up protein aggregates from amyloid forming proteins. Can you tell me more about that?
Certainly! Guanidine hydrochloride is a strong denaturant that can be used to unfold proteins and disrupt protein-protein interactions. This can lead to the disaggregation of protein aggregates, including those from amyloid forming proteins. However, it can also have detrimental effects on the stability and folding of other proteins, so it must be used with caution.