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How does Hutchinson–Gilford progeria syndrome affect/disrupt protein translation?
How does progerin disrupt protein translation exactly?
Progerin interferes with the normal processing of the mRNA molecules that carry instructions for making proteins. Normally, the mRNA is processed and transported out of the nucleus and into the cytoplasm, where it can be translated into protein. However, in cells with progerin, this process is disrupted, leading to a buildup of mRNA within the nucleus and a decrease in protein production.