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How does hypokalemia lead to polyuria in primary aldosteronism?
Is there a specific mechanism behind how hypokalemia causes polyuria?
Yes, there are a few different mechanisms. One is that decreased levels of potassium can lead to increased activity of the renin-angiotensin-aldosterone system, which can further exacerbate sodium retention and potassium excretion. Additionally, hypokalemia can cause alterations in renal tubular function and impair the ability of the kidneys to concentrate urine, leading to increased urine output.