text: Rebecca Tarvin
  
  Assistant Professor
  
  Research Description
  
  I am broadly interested in integrating studies of natural history with molecular genomics and phylogenetics. Specifically, I aim to elucidate causal genetic mechanisms underlying novel traits, characterize phenotypic diversification at macro and micro-evolutionary scales, and identify factors that promote and constrain biodiversity. Research in my lab often involves merging fieldwork, labwork, and bioinformatics to get at the molecular mechanisms and evolutionary forces underlying adaptive traits. Below I detail several of my ongoing research projects.
  
  Over the last 50 million years, poison frogs (family Dendrobatidae) have evolved to sequester alkaloids from diminutive arthropod prey three independent times, paired with parallel changes in metabolism, skin morphology, diet, coloration, behavior, and neurophysiology. Thus, I study genomics of poison frogs to identify mechanisms underlying the origins and diversification of complex novel phenotypes.
  
  Evolutionary transitions underlying large-scale phenotypic change (as in the poison frogs) are difficult to study because they often occur over millions of years. However, the fruit fly has a short generation time and a small genome. Thus, I am using experimental evolution to evolve toxin-sequestering fruit flies. Evolutionary changes in the fruit fly genome, transcriptome, and physiology will generate a model of how chemical defense arises that will inform studies in non-model organisms.
  
  The evolution of acquired neurotoxic defenses requires myriad changes in an organism's nervous system and physiology. Using target-bait capture, I am sequencing genes involved in these sensory and physiological processes in three clades of aposematic frogs. Behavioral experiments paired with physiological assays will evaluate how identified genetic changes produce novel phenotypes.