Reviewer response for version 1
The paper is well-written with appropriate title and adequate abstract. 
There are, however, several minor comments.
- The authors mention in passing the results of Helwak et al. 
Would it be possible to validate the predicted seed regions using the data from the CLASH experiments?
- The results appear to agree with their previous work in Drosophila, with the difference that Ago IP was used in the flies. 
This difference is not discussed in sufficient detail here and needs to be further elaborated.
- Have the authors considered a “target” of the tRNA itself, from which a fragment is produced? 
After all, there is base complementarity in the stem for both 5’ and 3’ tRFs.
- A recent paper in Science 1 implicated possible tRF matches in promoter regions. 
Have the authors considered these targets?
Structure
Strength
Structure
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Recap
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