Reviewer response for version 1
This report look at Vanishing White Matter disease (VMD), part of the genetically inherited leukoencephalopathies, a rare group of neurological disorders, of which X-linked adrenoleukodystrophy is the most common (1/17,000). 
VMD is an autosomal recessive disorder characterised by progressive neurological impairment and white matter cystic degeneration. 
It generally presents in childhood but adult cases are well reported.
Here a 30 year old woman reports a short duration of weakness, ataxia and primary infertility. 
An older sister also has VMD (there are siblings in total).
In females there can be ovarian failure, which is a useful diagnostic feature, as is shown here (so it can be described as an ovarioleukodystrophy). 
The periventricular white matter shows the same signal intensity as CSF on FLAIR/T2 weighted imaging. 
Mutations occur in any of the 5 genes that code for translation initiation factor EIF2B ( EIF2B1 – EIF2B5 ), here is EIF2B. 
Sometimes deterioration is triggered by physical or emotional trauma.
This is a useful addition to the literature of a very rare group of conditions.
Structure
Recap
Other
Other
Recap
Recap
Other
Recap
Recap
Other
Strength