Susquehanna Township was first surveyed in 1769. The surveyors named it "Upper Bottom" to distinguish it from a piece of land further to the east that was named "Lower Bottom", present-day Duboistown and South Williamsport. The first settlers arrived in 1801 and cleared the alluvial plain near the West Branch Susquehanna River and began farming. The village of Nisbet, a collection of about a dozen homes, rose up around the railroad station of the same name. Two grist mills and a small textile mill were built on Mill Run during the early days of Susquehanna Township.