On 12 April 2006, Rajkumar returned to his Sadashivanagar residence after his regular 20-minute walk and had a general medical check-up by 11:30 a.m. (IST). At 1:50 pm (IST), as he sat on a sofa, he asked a member of his family to slow the fan down and immediately collapsed. His personal physician Ramana Rao was called for, who rushed within three minutes, and performed external cardiac massage and mouth-to-mouth resuscitation. Rajkumar was then taken to MS Ramaiah Memorial Hospital and was administered intracardiac injections. Efforts to revive him failed and he was pronounced dead at 2:05 pm (IST). His death occurred 12 days before his 77th birthday. His eyes were donated to two visually impaired persons the same day.