His next appearance came in week 8 against the Buffalo Bills. A struggling Pennington was pulled by head coach Eric Mangini in the middle of the fourth quarter and replaced by Clemens. Clemens led two drives against the Buffalo defense. Down 13–3 and pressed for time, Clemens attempted to quickly move the Jets offense down the field but was intercepted twice. The following day, on October 29, 2007, Clemens was named the starting quarterback for the next game against the Washington Redskins. In the 23–20 loss, he had 226 passing yards and a passing touchdown. He finished the 2007 season with 1,529 passing yards, five passing touchdowns, and ten interceptions in 11 games.