DeRogatis hosts "Sound Opinions" with fellow music critic Greg Kot. The radio talk show is heard on Chicago Public Radio and nationally syndicated by American Public Media and is available as a podcast. The program is one of the longest running talk radio shows focusing exclusively on rock music with stints on both Chicago's WXRT and an early incarnation on Q101 featuring Bill Wyman from the Chicago Reader in place of Greg Kot. The move to Chicago Public Radio took place on December 3, 2005.