In the 2005 election, Wilkinson was a candidate for the National Party, standing in the Waimakariri electorate and ranked 38th on the party list. She entered Parliament as a list MP. She has made a successful start to her career in politics, rising to 28th on the list, and eventually becoming a Cabinet minister. Although unsuccessful in terms of electorate vote again (losing to incumbent Clayton Cosgrove of the Labour Party by 390 votes in the 2008 election – the second narrowest margin in the country), National won a commanding margin in the party vote.