After arriving on Virginia Key, the road passes by the University of Miami's Rosenstiel School of Marine and Atmospheric Science, NOAA's Atlantic Oceanographic and Meteorological Laboratory (AOML), the Miami Seaquarium, MAST Academy (the former site of Planet Ocean), and the Miami Marine Stadium. The William M. Powell Bridge carries traffic over Biscayne Bay. The road passes by more beaches on a short and thin barrier island before it reaches the toll plaza for the southbound Rickenbacker Causeway on the mainland, where state maintenance begins. The road's state road designation ends at I-95, but the road itself continues into Miami's The Roads neighborhood as Southwest 26th Road.