Arencibia was the starting catcher at the Blue Jays' 2011 home opener. He hit the team's first home run of the season, a 2-run homer to deep center. He finished the night with 2 home runs and a triple. On May 7, he broke up Justin Verlander's perfect game, being walked after a 12 pitch at-bat. On June 3 against the Baltimore Orioles, Arencibia hit his first career grand slam in an 8–4 victory. As of June 4, Arencibia led all major league rookies with 9 home runs, which is already a Blue Jays club record, surpassing the previous record of five, shared by Pat Borders (1988) and Greg Myers (1990).