The song has been featured in numerous video games, including a cover version of the song that featured in the PlayStation 2 video game "Guitar Hero", with the Master Version of this song released as Downloadable Content for both "Guitar Hero 5" and "Rock Band 3" (along with a Pro Guitar/Bass upgrade available). A master track is also available as DLC in "Rocksmith", along with and "Hangar 18" and "Public Enemy No. 1". A remix was used in the video game "WWE SmackDown! vs. Raw 2006" and '. Furthermore, song is featured in the video games ', "NFL Street 3" and "FlatOut 2". In the MOBA game League of Legends, a champion known as Mordekaiser used to have the ability Siphon of Destruction, a reference to the song.