When the Nelson band dissolved in 1964, Osborn turned to studio work in Los Angeles full-time. For the next ten years, he was considered a "first-call" bassist among Los Angeles studio musicians (known as The Wrecking Crew), and he worked with well-known producers such as Lou Adler and Bones Howe, frequently in combination with drummer Hal Blaine and keyboardist Larry Knechtel—the combination of Blaine, Osborn and Knechtel have been referred to as the Hollywood Golden Trio. His bass can be heard on many of the hit records cut in Los Angeles during that time, along with numerous film scores and television commercials.