Clayton gained national attention as president of her Democratic freshman class in Congress. During her ten years of distinguished service as a United States Congresswoman, Clayton served on the House Agriculture Committee and as the ranking member of the United States Department of Agriculture's Operations Oversight, Nutrition, and Forestry Subcommmittees. She also served on the House Budget and Small Business Committees. She was actively engaged in the legislative development of the Department of Agriculture's Operation policy. She was a conferee on the 2002 Farm Bill and is recognized by national organizations, including the "National Journal" publications, for providing essential leadership by garnering support for nutritional programs and the civil rights and support for African American farmers in the final version of the Farm Bill. She provided additional leadership by serving as the bipartisan co-chair of the Rural Caucus and as the chair of the Congressional Black Caucus Foundation.