On May 16, 2012, Arencibia reached 100 RBI for his career in a 4-1 win against the New York Yankees. The following day, in a game against the New York Mets, Arencibia set a career high for RBI in a game with 6, in a 14-5 win. Arencibia also hit 2 home runs, giving him the first 3-game home run streak of his career. Arencibia was named AL Player of the Week for May 14–20, hitting .360 with 4 home runs, 10 RBI, 7 runs scored, and a slugging percentage of .920. He is the first catcher in Blue Jays history to win the award. On July 25, in a game against the Oakland Athletics, Arencibia was hit on the right hand by a pitch while catching. Arencibia finished the inning, but left the game for precautionary reasons. X-rays came back positive for a fracture, and he was expected to miss 6 weeks. Arencibia began a rehab assignment with the Class-A Dunedin Blue Jays on September 2. He finished the season with a .233 batting average, 18 home runs, and 56 RBI.