At least 9 frameshift mutations in the'"ETV6" gene have been associated with ~12% of adult T cell Acute lymphoblastic leukemia cases. These mutations involve insertions or deletions in the gene that lead to its encoding a truncated and therefore inactive ETV6 protein. These mutations commonly occur alongside mutations in another oncogene, "NOTCH1", which is associated with T cell acute lymphoblastic lymphoma quite independently of ETV6. It is suggested that suppressor mutations in the "ETV6" gene may be a contributing factor in the development ant/or progression of this leukemia type.