In the summer of 1425, Ierissos came into the hands of the Turks. During that time the Venetians, starting from Cassandreia, landed on the coastline of Ierissos, burnt down the settlement (by then only a large village) and its surroundings and (on departure) set alight the castle and five towers. Under Ottoman rule, Ierissos was one of the privileged Mademochoria. In 1821 Ierissos took part in the Greek War of Independence and during the repression the village was burnt down by the Turks and a large number of residents killed.