The school was founded in 1920 as the City Boys' School, on East Bond Street. In 1928 it moved to Humberstone Gate, to the former buildings of the Wyggeston Hospital Girls' School, which moved to a site in Regent Road which is now the Regent College sixth form. After 1944 the City Boys' School became City of Leicester Boys' Grammar School. In 1966 it moved to the Wyvern building on Downing Drive. The Humberstone Gate building, built in 1878, was used for a few years by Charles Keene College (subsequently merged with Southfields College to form Leicester College) and is now the Leicester headquarters of Age Concern.