During the lock-out year of 2004–05, Fisher played overseas for EV Zug in the Swiss Nationalliga A. As NHL play resumed the next season, in 2005–06, Fisher emerged with 22 goals and 44 points, providing valuable secondary scoring for the Spezza-Heatley-Alfredsson line. He helped the Senators to a first seed in the Eastern Conference going into the playoffs, but they were defeated by the fourth-seeded division rivals Buffalo Sabres in five games in the second round. With a career-high plus-minus (+/-) rating of +23 in the regular season, Fisher was nominated for the Frank J. Selke Trophy as the best defensive forward. He finished as second runner-up behind Jere Lehtinen of the Dallas Stars and trophy-winner Rod Brind'Amour, captain of the Stanley Cup champion Carolina Hurricanes.