There is a closely related entity that is now referred to as Bloom-syndrome-like disorder (BSLD) which is caused by mutations in components of the same protein complex to which the "BLM" gene product belongs, including "TOP3A", which encodes the type I topoisomerase, topoisomerase 3 alpha, "RMI1", and "RMI2". The features of BSLD include small size and dermatologic findings, such as cafe-au-lait spots, and the presence of the once pathognomonic elevated SCEs is reported for persons with mutations in "TOP3A" and "RMI1".