In issue #28 of Garth Ennis's comics series "Preacher", Jesse Custer is sitting in front of the painting in the MoMA, examining it. In issue #43, the story of which is titled "Christina's World", Jesse relates his visit to the museum to his mother, Christina L'Angell, who explains to him that when she first discovered the painting in a book, she thought Wyeth had painted her own life. In addition, the cover to issue #43 by artist Glenn Fabry is a variation of "Christina's World", with Christina in the role of Anna Christina Olson.