Dupuis gained popularity in Quebec as Ovila Pronovost in the series "Les Filles de Caleb" (also known as "Emilie") when it premiered on Radio-Canada (1990–92), and he co-starred as the journalist Michel Gagné in four seasons of "Scoop" (1991–95). He was introduced to the American public on television as Oliva Dionne in "Million Dollar Babies" (1994)--"Les jumelles Dionne: La véritable histoire tragique des quintuplées Dionne" ("The Dionne "Twins": The True Tragic Story of the Dionne Quintuplets"). In the United States, he also debuted on the big screen in such film roles as Becker in "Screamers" (1995) and as John Strauss in "Bleeders" (1996), also known as "Hemoglobin" (1997) in the UK. In 1997 he began appearing as Michael Samuelle in the television series "La Femme Nikita", also known as "Nikita". Recently, he won a MetroStar Award for his role as Ross Desbiens in "Le Dernier Chapitre: La Vengeance" (2003), the sequel to "Le Dernier Chapitre" (2002), both filmed simultaneously in dual-language versions broadcast in French and English on Radio-Canada and the CBC, respectively.