He appeared as Dr. Kern in the September 12, 2011, episode of the Syfy channel program "Alphas" entitled "Blind Spot". In October 2011, he appeared as himself in the episode "The Russian Rocket Reaction" of "The Big Bang Theory". The day after his guest appearance, it was announced that Spiner would guest-star in the "Young Justice" episode "Revelation", providing the voice of the Joker. Spiner has also guest-starred on the Syfy program "Warehouse 13" as Brother Adrian in the third and fourth seasons.