I-376 then passes to the east of West Mayfield and becomes a non-tolled highway again at its first interchange with PA 51 in Chippewa Township, just west of Beaver Falls. The freeway then weaves through mountainous terrain, interchanging with PA 68 in Vanport just before crossing the Vanport Bridge over the Ohio River. It then has its second interchange with PA 18 near Kobuta and continues south from there. I-376 passes to the west of Aliquippa before leaving Beaver County and entering Allegheny County.