In the scientific community, Singer was best known and respected for her studies in schizophrenia and family therapy. She conducted research with the National Institute of Mental Health, the United States Air Force, and the Massachusetts Institute of Technology. Singer was a guest lecturer of psychology at UC Berkeley from 1964 to 1991, and she served as a faculty member and/or lecturer at other UC campuses as well as the Albert Einstein College of Medicine, the University of Rochester, and other institutions.