The Netherlandish painters did not approach the creation of a picture through a framework of linear perspective and correct proportion. They maintained a medieval view of hierarchical proportion and religious symbolism, while delighting in a realistic treatment of material elements, both natural and man-made. Jan van Eyck, with his brother Hubert, painted "The Altarpiece of the Mystical Lamb". It is probable that Antonello da Messina became familiar with Van Eyck's work, while in Naples or Sicily. In 1475, Hugo van der Goes' "Portinari Altarpiece" arrived in Florence, where it was to have a profound influence on many painters, most immediately Domenico Ghirlandaio, who painted an altarpiece imitating its elements.