Of its bishops, Lucianus professed the faith of the First Council of Nicaea at a synod held in Antioch in 363, Alexander was at the First Council of Constantinople in 381, Reverentius became archbishop of Tyre, Marcellinus was a participant at the Council of Ephesus in 431, Epiphanius took part in a synod at Antioch in 448, and Heraclitus participated in the Council of Chalcedon in 451 and was a signatory of the letter that the bishops of the province of Syria Phoenicia sent in 458 to Byzantine Emperor Leo I the Thracian to protest about the murder of Proterius of Alexandria.