In 2010, Conrad frequently picked up clutch hits at the end of games, but committed defensive miscues at the end of the season and postseason. On May 20, 2010, Conrad came to the plate with one out, the bases loaded in the bottom of the 9th, with the Braves trailing 9–6. He hit a walk-off grand slam against Cincinnati Reds pitcher, Francisco Cordero, to cap an eight-run comeback for his team. On June 12, 2010, he dropped down an eventual game winning suicide squeeze bunt to score Gregor Blanco in the 9th inning against the Minnesota Twins. On July 24, 2010, Conrad hit his second go-ahead grand slam of the year, in the 8th inning against Burke Badenhop of the Florida Marlins. The Braves went on to win, 10–5. On August 10, 2010, with a runner on first and no outs in the top of the 9th, Conrad hit a two-run homer to put the Braves ahead of the Houston Astros, 3–2, in a game that the Braves would go on to win. Nicholas James Baker caught the home run ball over the rail of the second deck in his hat. On August 13, 2010, Brooks hit his final game-winning home run of the season. This one came in the bottom of the 7th, against Hiroki Kuroda of the Los Angeles Dodgers.