Eric Clapton recorded the song for "Me and Mr. Johnson" (2004), his album devoted to Johnson's songs. Clapton quotes one of Johnson's verses for the Derek and the Dominos' song "Layla": "Please don't say we'll never find a way, and tell me all my love's in vain". Jazz singer Madeleine Peyroux adapted it for her 2011 album "Standing on the Rooftop". An album review in "The Guardian" noted, "A major highlight is the echoing, gothic account of Johnson's Love in Vain." Walter Trout recorded it for "Prisoner of a Dream" (1990) and Keb' Mo' for "Slow Down" (1998). Todd Rundgren included the song on his Johnson tribute album, "Todd Rundgren's Johnson" (2011).