Since 11 July 2010, Yoo has hosted the urban action variety "Running Man" together with fellow "Infinite Challenge" member Haha, fellow "Family Outing" member Kim Jong-kook, other entertainers such as Ji Suk-jin, Leessang's Gary (who left since episode 324 to focus on his music career), Song Ji-hyo, Lee Kwang-soo, Song Joong-ki (who left since episode 41 to focus on his acting career), Lizzy of After School (who left for unknown reasons), Jeon So-min and Yang Se-chan (both joined since episode 346). Although the program did not have a good start in ratings, it later became very popular and has held a consistent international fanbase to this day.