LA 10 travels through Jackson on Charter Street, the town's central thoroughfare. After several blocks, it intersects LA 952 (College Street). At the eastern edge of town is an intersection with LA 68 (Carrs Creek Road), connecting to Wilson on the north and Baton Rouge via US 61 on the south. east of Jackson, LA 10 crosses over the Gloster Southern Railroad (GLSR) line at a point known as McManus. Shortly afterward, the highway intersects LA 19, another north–south route connecting to Baton Rouge and Wilson. After heading northeast for , LA 10 curves due east at an intersection with LA 963. The highway passes between a residential development and a large tract of open land shortly before intersecting LA 955, which heads south through Grays to a point near Slaughter. later, LA 10 enters Clinton, the parish seat, running along St. Helena Street. LA 10 intersects LA 67 at Liberty Street, and the two highways run concurrent for two blocks until LA 67 turns south onto Plank Road, the town's main connection to Baton Rouge. On the way out of Clinton, LA 10 curves to the northeast and continues for before crossing the Amite River into St. Helena Parish.