M-65 is maintained by the Michigan Department of Transportation (MDOT) like all other state highways. As a part of these responsibilities, the department tracks the volume of traffic using the roads under its jurisdiction. They use a metric called average annual daily traffic (AADT), which is a statistical calculation of the average daily number of vehicles on a segment of roadway. In 2009, MDOT's surveys calculated that the highest volume of traffic along M-65 was 6,699 cars north of the M-55 junction; the highest commercial AADT was 310 trucks along the River Road National Scenic Byway segment north to the F-30 junction in Glennie. The lowest traffic counts were the 947 cars and 107 trucks near the northern terminus in Presque Isle County. The section of M-65 concurrent with M-32 has been listed as a part of the National Highway System, a network of roads important to the country's economy, defense, and mobility.