Born in Giffordgate, a street in Haddington, East Lothian, Knox is believed to have been educated at the University of St Andrews and worked as a notary-priest. Influenced by early church reformers such as George Wishart, he joined the movement to reform the Scottish church. He was caught up in the ecclesiastical and political events that involved the murder of Cardinal David Beaton in 1546 and the intervention of the regent Mary of Guise. He was taken prisoner by French forces the following year and exiled to England on his release in 1549.