In the fall of 2005, Sánchez joined the cast of the CBS television series "Without a Trace", where she played Agent Elena Delgado to 2009. She composed the musical "Yellow", about a singer/dancer/actress who leaves Puerto Rico to hit the big time in New York, in which she played the principal part. The movie was filmed in 2005 and released in 2007. Also in 2007, she acted as Monique, the ballet teacher, in "The Game Plan", and in 2009, starred in "The Perfect Sleep", a neo-noir drama, co-starring Patrick Bauchau, Tony Amendola, Isaac Singleton, and Peter Lucas. In 2011, Sánchez made a guest appearance on TNT's "Rizzoli & Isles", playing villainous attorney Valerie Delgado.