In Holden Heights, US 441 has an interchange with I-4 (Exit 80). Eastbound access from I-4 comes from partial cloverleaf ramps, and westbound access comes from a left-turn ramp between the two carriageways that runs under the eastbound lane and merges with the east to southbound ramp before merging with southbound OBT. The interchange provides no south to east access and no west to north access, but such access can found from the intersection with West Michigan Street. Further north the road heads into Orlando and comes to the interchange with SR 408 (East-West Tollway) at exit 9, which is a diamond interchange. After curving around Givens Street and Springdale Road, both of which can only be accessed from West Concord Street, OBT moves closer to a parallel railroad freight line and meets the intersection of SR 50 (Colonial Drive) northwest of downtown. Here, US 17/92 turns east onto State Road 50 while US 441 continues north on the Orange Blossom Trail. North of downtown, US 441 encounters intersections with State Road 438, then State Road 416, and after running along the western edge of Lake Fairview, an intersection with State Road 423 which changes from the north-and-south John Young Parkway to the east-and-west Lee Road.