The James E. Ross Highway portion of I-376 between US 422 and PA 51 uses all-electronic tolling, with tolls payable by toll-by-plate (which uses automatic license plate recognition to take a photo of the vehicle's license plate and mail a bill to the vehicle owner) or E-ZPass. The tolled section of I-376 has two mainline toll plazas: the West Mainline Toll Plaza near milepost 18 and the East Mainline Toll Plaza near milepost 30. As of 2021, the West Mainline Toll Plaza costs $4.60 using toll-by-plate and $2.30 using E-ZPass for passenger vehicles while the East Mainline Toll Plaza costs $2.90 using toll-by-plate and $1.20 using E-ZPass for passenger vehicles. There are also ramp tolls at the eastbound exit and westbound entrance at exit 17, the westbound exit and eastbound entrance at exit 20, and the eastbound exit and westbound entrance at exit 29, which charge $2.90 using toll-by-plate and $1.20 using E-ZPass for passenger vehicles. As part of Act 44, tolls are to be increased every year in January.