Guyasuta made acquaintance with young George Washington (whom he called "Tall Hunter") in 1753 when he accompanied and guided him through Pennsylvania to the French Fort Le Boeuf, and is referred to as "The Hunter" in Washington's personal journals. Despite the expedition, Guyasuta played a role in defeating the Braddock Expedition in 1755, and allied with the French in the French and Indian War. Guyasuta was a major player in Pontiac's Rebellion—indeed, some historians once referred to that war as the "Pontiac-Guyasuta War".