Domenech served as one of the national co-finance chairs of Ready for Hillary, and coordinated fundraisers for the super PAC in and out of Puerto Rico, from California to Washington, DC. He served on the National Finance Committee for Hillary Clinton presidential campaign, 2016, was her top fundraising bundler from Puerto Rico, assisted in organizing her first campaign trip to Puerto Rico in the current election cycle, which took place on September 4, 2015. He additionally served as the campaign manager for her successful primary camping in Puerto Rico, where she polled a 61–37, margin of victory over Sen. Sanders in the June 5, 2016 Puerto Rico Democratic primary, 2016.