"Kane" arrived in Pearl Harbor 18 January 1944 to join the 5th Amphibious Force for the capture of the Marshall Islands. Her Marine escort secured the channel islets at the entrance of Majuro Lagoon on the night of 30 to 31 January 1944 and later took the islands on the east side of Kwajalein Lagoon. She sailed 25 February to help screen amphibious landing ships for the invasion of Milne Bay, New Guinea, then entered Seeadler Harbor, Manus, as the 7th Cavalry Regiment took the remaining strong point in the Admiralty Islands. The high speed transport landed men of the 163d Infantry at Aitape 22 April 1944, and bombarded enemy positions before withdrawing to shell Ali Island. After escorting a convoy to the Solomon Islands she returned to Pearl Harbor 23 May 1944.