Ampoules can be pressurised, have air evacuated from them, and have the air in the ampoule replaced with other gasses, often inert ones. The radio-pharmaceutical Xenon-133 often is packaged in glass ampoules and specially-shaped glass ampoules have long been used for samples of gaseous elements, such as all of the Column 18 Noble Gasses save radon (mainly because it is radioactive with a half life less than half a week) and special thick-walled quartz and fluorite ampoules under high pressure containing fluorine and chlorine liquified by the high pressure