Wilkinson resigned her portfolio as Minister of Labour on 5 November 2012, following the publication of the Royal Commission of Inquiry's report into the 2010 Pike River Mine disaster. It stated that there were major flaws in the Department of Labour, and recommended "sweeping changes" into the department. In a statement, Prime Minister John Key said, "Ms Wilkinson's decision to resign is a personal decision in response to the magnitude of the tragedy. It is the honourable thing to do. I considered it proper for me to accept her resignation from the Labour portfolio." She retained her other portfolios and was succeeded in the Labour portfolio by Chris Finlayson.