Spiner has appeared in many television series, including "Deadly Games", "The Blacklist", "Dream On", "Gargoyles", ', "Mad About You" and "The Outer Limits". In the series "The Big Bang Theory" and "Joey", he appeared as himself. He has acted in the movies "The Aviator", "Dude, Where's My Car?", "I Am Sam", "Independence Day", ', "The Master of Disguise", "Out to Sea", "Phenomenon", "The Ponder Heart" and "". His television-movie appearances during this period include the 2000 musical "Geppetto" and the role of Dorothy Dandridge's manager and confidant, Earl Mills, in the HBO production "Introducing Dorothy Dandridge".