In support of the album, Interscope Records released three singles from "Fear of Flying". Initially, before "The Best of Me" was chosen as the album's lead single, the song "Lie Detector" was considered as a potential contender. The instrumental for "The Best of Me" was originally expected to be used and recorded by rapper DMX in a Miami recording session with Swizz. However, the instrumental of the song was left unused until the producer returned to New York City to start work on Mýa's album at The Hit Factory. Upon accidentally pushing a button in the studio, Mýa's management reportedly "jumped up and said 'That's it, that's it'" when they heard the songs instrumental. The record was among the last tracks that were recorded for the album. Jadakiss, a then member of the Ruff Ryders Entertainment's group The LOX, was chosen as the featured artist on the song as a result of label connections with Interscope Records. Released on March 6, 2000, "The Best of Me" peaked at number 50 on the "Billboard" Hot 100 and number 14 on the Hot R&B/Hip-Hop Songs chart. Internationally, the single found modest chart success peaking at number 26 in Germany, while charting moderately in Netherlands and Switzerland.