U.S. Route 40, also known as the Historic National Road and the Cumberland Road, passes through the middle of Plainfield and is the main arterial route running east to west in the town. It leads northeast to downtown Indianapolis and southwest to Terre Haute. From north to south, State Road 267 connects Plainfield to the neighboring towns of Avon and Mooresville, and it provides access to Interstate 70, about south of US-40. Plainfield's historical town center is situated around the intersection of U.S. Route 40 and Center Street, also known as Old State Highway 267.