Vázquez Jr. debuted as a professional in an event that took place on December 18, 2006 in Kissimmee, Florida. In this event he fought against Octavius Davis who was also debuting as a professional, Vázquez won the fight by knockout in the first round. His second professional fight was on February 2, 2007, against Daniel Lornezano in a boxing card presented in Miami, Florida. Vázquez won three more fights by knockout over the course of the first half of 2007, against Danny Esquivel, Cature Hicks Juan Camacho and Jaime Villa, on cards that took place in Kissimmee and Miami. Vázquez participated in his first fight outside Florida on August 25, 2007, in a card that took place in Bayamón, Puerto Rico. In this event, he defeated Anthony Chacon via knockout on the first round. On September 14, 2007 Wilfredo participated in a fight scheduled for six rounds for the first time in his career, he won the fight by technical knockout in the third round. On December 15, 2007, Vázquez fought Jorge Cardenas in Cancún, Mexico. The judges scored the fight as a draw, marking the first instance that he did not win in his professional career. His return to the ring was on March 28, 2008, when he fought against Corey Goodwin, winning the contest by knockout in the third round. Two months later, he defeated Moises Carrasquillo by knockout. On July 26, 2008, Vázquez defeated Felipe Almanza by disqualification. The result was determined after Almanza tried to kick Vázquez after the fourth round had concluded. His first title opportunity took place on September 12, 2008, when he fought Adolfo Landeros for the vacant WBO Latino Super Bantamweight Championship. Vázquez won the regional championship by technical knockout in the eighth round.