During his journalism career, Nobile has written for "The New York Press," "New York Magazine," "The Village Voice," "The New York Review of Books," "Harper's Magazine," "Penthouse", "Spin," "Spy Magazine," "Esquire," "Newsday," "The Weekly Standard," and "The New York Post" among other publications. He wrote on the idea of “positive incest” in a 1977 article on Warren Farrell in "Penthouse" that questioned the incest taboo. He was an editor, along with Eric Nadler, of "Penthouse Forum." In addition he is a regular contributor to the online "History News Network." As a "muckraking" investigative journalist and media analyst, Nobile has generated controversy by his criticisms of a variety of public figures, including sexologist Shere Hite, talk radio host Don Imus, historians Doris Kearns Goodwin and David McCullough, and President Harry S. Truman.