On March 13, 2009, Vázquez returned to action, defending the WBA Fedecentro Championship against José Ángel Beranza. Early in the fight, both pugilists exchanged punches, before Vázquez was able to employ a calm pace which favored him. Early in the third round, Beranza displayed a better offensive, but lost control of the fight’s tempo later in that round. Vázquez began the fourth round on the offensive, with this pace continuing throughout the chapter. After receiving a warning for "roughhousing" in the fifth, Beranza was unable to respond effectively during the sixth and seventh. Using this to his advantage, Vázquez pressured the offensive and established control of the fight’s tempo. Beranza was eventually deducted a point for using illegal tactics. After the twelfth round, the fight's outcome was decided by the judges, who gave scores of 118-109, 119-108 and 120-106 in favor of Vázquez. On July 17, 2009, he fought Cecilio Santos, winning by knockout in the second round. On November 20, 2009, Vázquez defended the regional title against Genaro García in a world championship eliminatory. He dominated the early stages by using jabs and moving, but García was able to pressure the fight as the rounds advanced. In the seventh round, both pugilists exchanged combinations, but Vazquez was able to score a knockdown and continued on the offensive. Consequently, the referee stopped the fight by technical knockout.