In 2001, Guillory continued with other roles in predominantly British films, including "Oblivious", "Late Night Shopping" (with husband Enzo Cilenti), "The Last Minute", and "". 2002 saw Guillory appear in "The Time Machine", alongside Guy Pearce and Jeremy Irons. She was pleased to take on a larger scale film, after having worked on low-budget independent films, and compared the experience with "finding an unicorn in your sock drawer". She played Emma, the fiancée of Pearce's character, who was killed early in the film and whose death set off its main events.