Highways Interstate 5 and CA 99 run, roughly parallel, north–south through the valley, meeting at only its south end. The Interstate 80 Business Loop connects the two highways at their closest point. Interstate 80 crosses it northeast–southwest from Rocklin to Vacaville. Interstate 80 and California State Route 58 are the two major routes east out of the Central Valley, over the Sierra Nevada. Other routes east over the Sierra Nevada include California State Route 178, California State Route 41 to California State Route 120 via Yosemite National Park, California State Route 88, and US Route 50. Westbound routes out of the valley are California State Route 166, California State Route 46, California State Route 152, Interstate 580, and Interstate 80. The major ones west out of the valley are Interstate 580, State Route 152 and State Route 46, over the Diablo Range. Other routes include California State Route 33, California State Route 198, California State Route 4, California State Route 130, and other smaller back roads and trails.