Her quick banter led to Garr being a regular guest on "The Tonight Show Starring Johnny Carson" and "Late Night with David Letterman". In the 1990s, she appeared in two films by Robert Altman: "The Player" (1992) and "Prêt-à-Porter" (1994), followed by supporting roles in "Michael" (1996) and "Ghost World" (2001). She also appeared on television as Phoebe Abbott in three episodes of the sitcom "Friends" (1997–98). In 2002, Garr announced that she had been diagnosed with multiple sclerosis, the symptoms of which had affected her ability to perform beginning in the 1990s.