The Arnwine Cabin was built using hewn poplar logs between 1795 and 1820, and its first known occupant was John Wesley Arnwine. The cabin was originally located along the Clinch River near the Liberty Hill community in Grainger County. In the early 1930s, the Tennessee Valley Authority acquired the cabin's tract for the construction of Norris Lake, and the cabin was moved a short distance. Two of Arnwine's daughters, Polly Anne (d. 1923) and Eliza Jane (d. 1936) lived in the cabin their entire lives, and after Eliza Jane's death the cabin was used for storage and fell into ruin. John Rice Irwin acquired the cabin in 1964 and moved it to the present museum site.