The film was critically panned, garnering a score of 7% on Rotten Tomatoes from 29 critics. The critical consensus reads: "A mean-spirited joke without a punchline, "Mr. Wrong" is so painfully unfunny that Ellen DeGeneres and Bill Pullman's lack of chemistry feels like a total drag despite being the point." Audiences polled by CinemaScore gave the film an average grade of "C-" on an A+ to F scale. Ellen DeGeneres was nominated for Worst Actress and won the award (without competition) for Biggest Acting Stretch (for playing a heterosexual woman).