Besides making the flag that inspired Francis Scott Key to compose the words to the United States National Anthem, Pickersgill is also remembered for her humanitarian contributions to society, evident in her decades-long presidency of the Impartial Female Humane Society, which eventually evolved into the Pickersgill Retirement Community of Towson, Maryland. She is also remembered for her house, known as the Star-Spangled Banner Flag House and later renamed the Flag House and Star-Spangled Banner Museum, which stands at the corner of East Pratt Street and Albemarle Street in eastern downtown Baltimore and is a National Historic Landmark.