The early history of Royton is linked closely with what was then its manor house, Royton Hall, which was inhabited by the Byron family for over 350 years. During that period the Byrons' involvement in regional and national affairs added prestige to what was otherwise an obscure and rural township. John de Byron was a witness to the charter of incorporation of 1301, which elevated the township of Manchester to the status of a borough. A descendant of John—John Byron—served as High Sheriff of Lancashire in 1572, and was knighted by Elizabeth I in 1579. John served as Deputy Lieutenant of Lancashire at the time of the Spanish Armada, and sourced infantry from Royton towards the English military. His son, also called John, fought during the English Civil War on the side of the Cavaliers. His actions led to making him John Byron, 1st Baron Byron of Rochdale by way of a peerage granted by King Charles I. Following the regicide of Charles I, and the rise of Cromwellian England, Baron Byron's possessions, including his lands in Royton, were confiscated. Royton Hall was then purchased by Thomas Percival, a wealthy linen manufacturer whose descendants continued to occupy the hall until around 1814. The hall was then inherited by the Radcliffe Baronets.