US 167 and LA 10 enter Ville Platte on West Main Street as an undivided four-lane highway with center turning lane, but the roadway soon separates to follow Main Street eastbound and LaSalle Street westbound, becoming a divided four-lane highway. Passing through the commercial section of town, the highway crosses the Acadiana Railway (AKDN) tracks and intersects LA 29 (South Chataignier Street). LA 29 begins a brief concurrency with US 167 and LA 10 before turning north onto Tate Cove Road. At this intersection, signs direct motorists to follow LA 29 northbound to reach I-49. Shortly afterward, the one-way couplet ends as US 167 and LA 10 proceed eastward out of Ville Platte as an undivided four-lane highway with center turning lane once again. Just outside the city limits, the highway narrows to two lanes and then curves to the southeast at LA 748 (Grand Prairie Road) en route to the St. Landry Parish line.