Little appeared in a string of Australian films and TV series during the 1980s. He also performed his own comedy/performance in Melbourne's burgeoning comedy clubs throughout the eighties. His longest-running television role was as Joe Mangel in the soap opera "Neighbours". He played the role for three years until 1991. The role gave his profile a big boost in the United Kingdom where "Neighbours" was being watched by ten million people every day at the time. He consequently has spent much of his career in the UK, living for much of the time near the seafront in Brighton and later north London.