In a few early episodes in the first season, Andy and Barney comment that they are cousins (initially as part of a joke implying that this relationship is responsible for Barney being hired as deputy), but this relationship is rarely mentioned later, and it is sometimes suggested in later episodes that they are not related. Genetics aside, Barney and "Ange" (as he frequently addresses Andy, a derivation from Knotts' real-life nickname for Griffith) are best friends, having grown up together in Mayberry, and graduated from the same class at Mayberry High School in 1945. Barney maintains warm relations with Andy's son Opie and his Aunt Bee.