Although the blue-eyed black lemur and the black lemur look similar, they can be differentiated by the blue eyes and lack of prominent ear tufts of this species, while the black lemur has orange-red eyes and long, spiky cheek hairs. In the Manongarivo Special reserve, where the range of the two species overlap, there is a report of hybridization between the two species, but the resulting offspring always have orange eyes. Until 2028, the blue-eyed black lemur was considered a subspecies, "E. macaco flavifrons", of the black lemur.