The castle occupied an important position on the border of the territory ruled by the French crown, as at the time, the papacy controlled the Comtat Venaissin on the opposite bank of the Rhône. During the 14th and 15th centuries the castle was the only residence with suitable accommodation for high-ranking dignitaries near the river between Pont-Saint-Esprit and Beaucaire; the Fort Saint-André and the Tour Philippe-le -Bel in Villeneuve-lès-Avignon served only a military function. During this period Roquemaure castle hosted a series of important guests.