During 2006, she appeared regularly in "Your Song", "Komiks", and "Love Spell"; she also topbilled the horror suspense film, "White Lady". In 2007, she starred in a fantasy series, "Rounin" and played the role of Aura. In the same year, Charlson appeared in the film, "A Love Story" with Aga Muhlach and Maricel Soriano from which she earned her first Best Supporting Actress trophy in the FAP Luna Awards. She also appeared in Judy Ann Santos' romantic soap opera, "Ysabella" as a guest character, and in December 2007, she played Lena in "" with Derek Ramsay, Toni Gonzaga, and the original cast: John Lloyd Cruz, Bea Alonzo, Sam Milby, and Anne Curtis. She became a full-fledged adult dramatic actress in the 2008 primetime drama series, "Iisa Pa Lamang" with Claudine Barretto. That series made her the Villain of the Year in the 1st Supreme to the Extreme Awards (Philippine Star), and she earned Best Drama Actress nomination in the 23rd PMPC Star Awards for Television.