Sacchini was born in Florence, but raised in Naples, where he received his musical education. He made a name for himself as a composer of serious and comic opera in Italy before moving to London, where he produced works for the King's Theatre. He spent his final years in Paris, becoming embroiled in the musical dispute between the followers of the composers Gluck and Niccolò Piccinni. His early death in 1786 was blamed on his disappointment over the apparent failure of his opera "Œdipe à Colone". However, when the work was revived the following year, it quickly became one of the most popular in the 18th-century French repertoire.