In 1850, Wyman was called to testify for the prosecution in the trial of Dr. John White Webster, on trial for the murder of Dr. George Parkman. His recognized authority as a comparative anatomist caused the coroner, Jabez Pratt, to call upon him to examine the bones when they were found in November 1849. His testimony concerned the fragments of bones found in the furnace. He cataloged them as to the parts of the body to which they belonged (noting that no bones were duplicates so that the fragments belonged to a single body), and his testimony regarding the jawbone contributed to the belief that the bones belonged to Dr. Parkman. Wyman also testified as to the alleged bloodstains found on pantaloons and slippers belonging to Dr. Webster.