In 2004, Charlson elevated herself as a mature actress in the movie, "Santa Santita" and gained Best Actress nominations in the Film Academy of the Philippines or FAP Luna Awards, FAMAS Awards, and ENPRESS Golden Screen Awards. She is also known for her dramatic performances in the movie, "A Love Story" and television series, "Iisa Pa Lamang" and "Rubi" wherein she received Best Actress and Best Supporting Actress awards and nominations in the Film Academy of the Philippines or FAP Luna Awards, ENPRESS Golden Screen Awards, and PMPC Star Awards. She also starred in horror films like: "White Lady", "Bulong", and "Segunda Mano" where she was recognized as Best Supporting Actress in the FAMAS Awards. In 2011, she earned Best Performance by an Actress in a Leading Role (Musical or Comedy) award in the 8th ENPRESS Golden Screen Awards for Movies and Comedy Actress of the Year award in the 42nd Guillermo Mendoza Memorial Scholarship Foundation for her role in "Here Comes The Bride." She also won several Best Comedy Actress awards and nominations in the ENPRESS Golden Screen and PMPC Star Awards for the gag show, "Banana Split".