Following the Hopman Cup, Radwańska failed to defend her title at the Apia International in Sydney, losing to Bethanie Mattek-Sands in the second round. Radwańska defeated Victoria Azarenka to reach her first Australian Open semifinal, but lost to Dominika Cibulková. Radwańska also reached the semifinal of the Qatar Total Open in Doha, losing to eventual champion Simona Halep. She avenged her loss Halep in the semifinal of the Indian Wells Masters, reaching the final for the first time in her career. Partly due to a knee injury, Radwańska was defeated by Flavia Pennetta. She was in tears while apologizing to the crowd afterward, saying she was unable to run. She then advanced to the quarterfinals in Miami, where she lost in three sets to Dominika Cibulková.