In 1993, the Japanese journal "Surgery Today" reported on the case of a 12-year-old girl. Only tall and weighing , her breasts began to develop at age 11 before the onset of menstruation. Over the next eight months, both breasts grew abnormally large, and physicians treating her found that her physiological development was normal except for her breasts. The weight produced by their symmetrical and massive enlargement resulted in marked curvature of the spine. Lab tests of her blood for hormones and biochemical substances showed normal values, though tests revealed that it might have been caused by hypersensitivity to estrogen. She underwent a bilateral reduction mammoplasty. Surgeons removed of tissue from her right breast and from her left breast. She was administered tamoxifen afterward to suppress breast regrowth.