Like its predecessor, the PZL.43 was conventional in layout, a low-wing, all-metal, metal-covered cantilever monoplane. Its fuselage was semi-monocoque. It had a crew of three: pilot, bombardier and an observer/rear gunner. The pilot and observer's cockpits were in tandem and glazed with the open rear gunner's position behind. The bombardier occupied a ventral combat gondola which had a machine gun position at the rear. The fixed undercarriage was heavily spatted, though not suited for rough airfields. Tanks in the centre section of the wings held 740 litres of fuel. A three-bladed propeller was used.