In England, Knox met his wife, Margery Bowes (died ). Her father, Richard Bowes (died 1558), was a descendant of an old Durham family and her mother, Elizabeth Aske, was an heiress of a Yorkshire family, the Askes of Richmondshire. Elizabeth Bowes presumably met Knox when he was employed in Berwick. Several letters reveal a close friendship between them. It is not recorded when Knox married Margery Bowes. Knox attempted to obtain the consent of the Bowes family, but her father and her brother Robert Bowes were opposed to the marriage.