SR 49 leaves Victoria as The Falls Road, named for the cataract where the state highway crosses the Nottoway River into Nottoway County. The state highway is also named Earle Davis Gregory Highway, named for Earle Davis Gregory, a World War I Medal of Honor recipient. At the river, SR 49 turns north, crossing Whetstone Creek and the Little Nottoway River before reaching the town of Crewe. The state highway crosses over Norfolk Southern Railway's Norfolk District just east of a rail yard. SR 49 turns northwest onto Virginia Avenue, where the highway joins US 460 in a concurrency. The two highways become West Virginia Avenue outside of the downtown area and parallel the rail yard to the west end of town, where SR 49 turns north onto Watsons Wood Road. SR 49 crosses Deep Creek before reaching its northern terminus at US 360 (Patrick Henry Highway) northeast of Burkeville.