Patients that may qualify for MUA to an extremity joint include those with stiff post-operative knee joints that have undergone total knee replacement (total knee arthroplasty- TKA). Range of motion data taken at discharge following TKA have been suggested as an indicator for MUA, when falling short of the “optimal zone” of ≥70˚ flexion combined with an extension deficit of ≤10˚. It appears that the ideal period for applying manipulation to knee stiffness after TKA is at less than 20 weeks from primary surgery, with no added benefit reported from re-manipulations. Similarly, another recent study also found that MUA is useful for decreased range of motion but the success rate of repeated MUA was less than that of the primary dose.