First inhabited for a short period in the second half of the fourth millennium BC, it was repopulated around 2800 BC and continued to grow. By 2000 BC, it became the capital of a regional kingdom that spread its authority over large swaths of the central and southern Levant. The kingdom enjoyed good relations with Mari, but was engaged in constant warfare against Yamhad. By the 15th century BC, Qatna lost its hegemony and came under the authority of Mitanni. It later changed hands between the former and Egypt, until it was conquered and sacked by the Hittites in the late 14th century BC. Following its destruction, the city was reduced in size before being abandoned by the 13th century BC. It was resettled in the 10th century BC, becoming a center of the kingdoms of Palistin then Hamath until it was destroyed by the Assyrians in 720 BC, which reduced it to a small village that eventually disappeared in the 6th century BC. In the 19th century AD, the site was populated by villagers who were evacuated into the newly built village of al-Mishrifeh in 1982. The site has been excavated since the 1920s.