Carl's grandson Mike Yastrzemski, Carl Jr.'s son, was drafted by the Red Sox in 2009 and the Seattle Mariners in 2012. However, he did not sign with either team, as he played college baseball for the Vanderbilt Commodores. He signed with the Baltimore Orioles after being selected in the 2013 MLB draft. He rose through Baltimore's farm system, reaching Triple-A with the Norfolk Tides by 2016. In March 2019, he was traded to the San Francisco Giants organization, and he made his MLB debut with the Giants on May 25, 2019.