Town began their Conference campaign with a 1–0 win at big-spending promotion favourites Crawley Town. Inconsistency followed, with the club managing to perform and get results against some of the league's top sides but struggling to beat the teams at the lower end of the table. After a long winter break due to postponements, Grimsby started the new year scoring 13 goals in 2 games, beating Mansfield Town 7–2 at home and Histon 6–1 at Bridge Road. After this, yet another inconsistent period followed that saw only 2 wins in 9 games and saw the club's play-off aspirations take a severe hit. As a result of this, Neil Woods was relieved of his duties on 24 February 2011 after 15 months in charge. He left the club in 9th position in the Conference National.