In Manhattan, "uptown" means north (more precisely north-northeast, which is the direction the island and its street grid system are oriented) and "downtown" means south (south-southwest). This usage differs from that of most American cities, where "downtown" refers to the central business district. Manhattan has two central business districts, the Financial District at the southern tip of the island, and Midtown Manhattan. The term "uptown" also refers to the northern part of Manhattan above 72nd Street and "downtown" to the southern portion below 14th Street, with "Midtown" covering the area in between, though definitions can be rather fluid depending on the situation.