From southeast to northwest, the business route begins at a cloverleaf interchange with both US 190, which continues east toward Hammond, and US 61, which continues south toward New Orleans. Both mainline routes come together to form a concurrency and continue northward along the Airline Highway, while the continuing road from US 190 becomes the business route. The route continues west through a primarily commercial area and past Baton Rouge Community College before entering downtown Baton Rouge. I-110 northbound has a direct exit to US 61/190 Business (Exit 1C) in downtown Baton Rouge, while southbound motorists must use N. 9th Street (Exit 1G) to connect directly to the business route. US 61/190 Business continues west through downtown until it reaches River Road where it turns right and continues north.