Ancrod was intensively studied in ischemic stroke, starting at least by the early 1990s. An RCT called "STAT" was published in 2000; it included 500 subjects and ancrod or placebo was administered within three hours of the stroke. Ancrod showed modest benefits but a trend toward increased intracranial haemorrhage. A clinical trial published in 2006 found no benefit if ancrod was given within a wider 6 hour treatment window. Another trial was launched to explore the 6 hour window, but it was halted early in 2008 when an independent review committee looked at the interim data and found no signal of benefit.