"The Perfect Prescription" "marked a serious artistic development, drawing deeper from gospel, ambient, and spiritual music, granting a serenity and depth to their spaced-out garage psychedelia" (Stephen Erlewine, "AllMusic"). Although retaining the same minimalist approach, Spacemen 3's sound was now sparser and mellower. Extra textures and complexity were evident, provided by overdubs and additional instrumentation, with the organ sound of the VHF Studio's Farfisa being a significant introduction. The instrumental palette was also extended with acoustic guitar, violin (from local musician Owen John), saxophone and trumpet (from members of The Jazz Butcher) being used on some songs. Much of the album did not feature drums. This was the first album on which Kember contributed lead vocals.