In the original Louisiana Highway system in use between 1921 and 1955, the modern LA 10 was part of several different state highways. West of the Mississippi River, these consist of State Route 257 from the western terminus at Pickering to Sandy Hill; State Route 118 to Cravens; State Route 22 to the modern junction with LA 749 west of Nuba; State Route 217 to Nuba; State Route 5 to Beggs; State Route 27 to Lebeau; State Route 1 to the modern junction with LA 77 east of Ravenswood; State Route 41 to Morganza; and State Route 30 to New Roads. The modern route bypassing New Roads and crossing the Mississippi River by bridge to US 61 at Starhill did not exist during the pre-1955 era.