San Giorgio a Cremano was first settled in the 10th and 11th centuries, and has since been fairly regularly affected by the eruptions of Mount Vesuvius. Along with Portici, Ercolano, Torre del Greco, and Torre Annunziata, San Giorgio a Cremano is one of the five traditional towns that were to be found heading south from Naples on the coastal road along the Bay of Naples. In the 18th century the comune had become a popular tourist resort, and attracted wealthier residents and the aristocracy from the Kingdom of the Two Sicilies, before going into decline following Italian unification, although primary industries and agriculture have persisted within the comune from its foundation to the modern day.