In Game 4 of the 2010 American League Championship Series, with 2 outs in the 6th inning and the Rangers trailing the New York Yankees, 3–2, Molina hit a three-run home run off A. J. Burnett. The home run, arguably one of the most important in Rangers history, proved to be the game-winner for the Rangers and gave the underdog Rangers a commanding 3–1 lead in the series. The Rangers won the ALCS against the Yankees in six games, which allowed the Rangers to enter the World Series for the first time in franchise history.