MD 63 begins at an intersection with MD 65 (Sharpsburg Pike) in the hamlet of Fairplay. The state highway heads west as Spielman Road, a narrow and curvaceous two-lane undivided highway through farmland and scattered residences. MD 63 crosses a one-lane bridge over Marsh Run just prior to Reichard Road; makes a sharp turn to the south adjacent to Marsh Mills; makes another sharp turn to the west; crosses a one-lane bridge over St. James Run; and crosses Norfolk Southern Railway's Hagerstown District at-grade in the hamlet of Spielman. The state highway widens as it starts to curve to the northwest through farmland, crossing Downey Branch and intersecting MD 632 (Downsville Pike) in the village of Downsville. MD 63 passes the historic home Rose Hill, crosses a Winchester and Western Railroad line at-grade, then makes a turn to the east and intersects MD 68 (Lappans Road). Governor Lane Boulevard continues east through an industrial park while MD 63 turns north to join MD 68 in a concurrency north into Williamsport.