The renewed Smith partnership is quickly threatened by their employers, who join forces to eliminate the couple. John's best friend and co-worker, Eddie (Vince Vaughn), turns down a bounty of $400,000, but John and Jane find themselves under fire from an army of assassins. Fending off an attack which blows up their pockmarked house, the Smiths steal their neighbor's minivan and successfully destroy their attackers' three pursuing armored sedans, all while bickering over their fighting styles and newly discovered personal secrets.