"Hopkins" sailed from Hampton Roads 2 October 1922, and reached Constantinople 22 October for duty in Turkish waters. She protected American interests and cooperated with the relief mission in the Near East, ranging to Beirut, Jaffa, and Smyrna. She departed Constantinople 18 May 1923 for New York, arriving 12 June. For the next seven years, "Hopkins" operated out of New England ports in the summer, Charleston, South Carolina, in the winter, and the Caribbean Sea in the spring. During the spring of 1930, "Hopkins" participated in force battle practice with aircraft.