Poibrene is located in the north-western part of the Pazardzhik Province on the left bank of the Topolnitsa river. The land of the village encompasses 108 km2 in Sashtinska and Ihtimanska Sredna Gora separated by the Poibrene Gap. The closest villages are Oborishte at 9 km to the east, Belitsa at 13 km to the west and Petrich at 14 km to the north. The centre of the municipality Panagyurishte lies at 18 km to the east. There are 3 buses from and to the capital Sofia and 5 buses from and to Panagyurishte daily.