The developed nature of the watershed of Darby Creek has caused it to be prone to storm surges during rains. Substantial amounts of nonpoint source pollution flows into the creek during storm events. Additionally, much of the older development in the watershed was built before current environmental regulations were enacted. In 2012, an article in "The Philadelphia Inquirer" stated that Darby Creek "is one of the country's most flood-prone streams, a significant drain on the National Flood Insurance Program, and a national lesson in what can go wrong along a developed waterway." A Superfund site known as the Lower Darby Creek Area site is located in the vicinity of the creek. This site consists of two landfills. Major roads in the watershed include Interstate 95 and Interstate 476.