The most valuable part of Quispe Tito's work is located in the church of his native town, San Sebastián. One highlight is the series of twelve compositions on the life of St. John the Baptist, in the main nave of the church. Of great mastery are also the two enormous canvases dedicated to Saint Sebastian, that of the "asaetamiento" and that of the death of the saint. Also famous is the series of the Zodiac that the artist painted for the Cathedral of Cuzco towards 1680.