LA 10 curves to the northeast toward Lebeau where it intersects US 71, connecting to Alexandria via Bunkie on the northwest and Krotz Springs on the southeast. From this intersection, LA 10 turns east and closely parallels the Union Pacific Railroad tracks through the village of Palmetto. Over the next , LA 10 travels through a largely unpopulated area that is part of the Atchafalaya Basin. The route continues along the UPRR tracks into the town of Melville where it becomes known as Lafleur Street. At Fontenot Street, LA 10 intersects and begins a brief concurrency with LA 105, a highway that generally runs along the west bank levee of the Atchafalaya River. LA 105 turns north onto Landrum Street and crosses under the UPRR tracks while LA 10 proceeds over the levee to a dead end at the Atchafalaya River, which forms the boundary between St. Landry Parish and Pointe Coupee Parish.