From Trondheim the line runs largely following the Trondheimsfjord to Steinkjer Station, traveling through the districts of Stjørdalen and Innherred. At Hell Station, from Trondheim, the Meråker Line branches off. North of Steinkjer () the line follows the east shore of Snåsavatnet until Snåsa Station (), passing into the district of Namdal. At Grong Station () the line intersects with the Namsos Line. It continues up the valley through an inland route and passes into the district of Helgeland. There it reaches a summit of above sea level at Majavatn Station () before descending back to sea level near Mosjøen Station (). The line continues along a rugged section often hugging the sides of fjords until Mo i Rana Station ().