On 11 May 2007, it was announced that she would be joining the cast of "EastEnders" as Roxy Mitchell, alongside Samantha Womack who played Roxy's sister Ronnie Mitchell. Of her role, Simons said: "I've always watched "EastEnders" and it's been my dream to become part of the Mitchell family." Simons temporarily departed from "EastEnders" in late 2015 (the character departed from screens from 1 January to 4 May 2016), allowing the actress to take part in a "Snow White" pantomime at the Marlowe Theatre in Canterbury, over the 2015/2016 Christmas and New Year period. In August 2016, it was announced that Simons was leaving "EastEnders" along with Samantha Womack. Her on-screen character Roxy Mitchell drowned in a swimming pool in an episode broadcast on New Year's Day 2017, along with her sister Ronnie.