At the 2013 TOPSHELF Open in 's-Hertogenbosch, Ferrer went out in the first round to veteran Belgian Xavier Malisse despite being the defending champion. His next tournament was Wimbledon, where he made it to the quarterfinals for the second consecutive year before falling to Juan Martín del Potro in straight sets. Ferrer had disastrous US Open tune-ups at the 2013 Rogers Cup and 2013 Western & Southern Open, winning only one match and losing to Russians Alex Bogomolov, Jr. in the second round and Dmitry Tursunov in the third round. He rebounded at the US Open, losing to Richard Gasquet in the quarterfinals in five sets despite taking the third and fourth sets, in his first loss since 2008 to the Frenchman.