Dembélé made an excellent start to his career at Fulham. He made his début on 22 August 2010, coming on as a substitute against Manchester United. He capped his first start for the club with a goal, scoring the second of six goals against Port Vale in the League Cup on 25 August. The same week, Dembélé made his first league start against Blackpool in which he provided two assists. The first of the two was a cross to Bobby Zamora following a good run in the box, while the second gave Fulham a draw and a point; he dodged past a couple of Blackpool players before playing a good ball for an on-rushing Dickson Etuhu to make the score (and final result) 2–2. Dembélé scored two league goals against Wolverhampton Wanderers on 11 September in a 2–1 win, his first league goals for Fulham. He then scored a great solo goal against Tottenham Hotspur, running from the halfway line before powerfully placing his shot beyond goalkeeper Heurelho Gomes. This was voted the Fulham "Goal of the Season" by the Fulham fans.