After entering rural western St. Helena Parish, LA 10 curves to the southeast and intersects LA 38 at Coleman Town, south of Chipola, followed by LA 448 at Darlington. LA 448 connects with LA 37 to Baton Rouge. Continuing southeast, LA 10 intersects LA 1043 to Liverpool. later, LA 10 enters Greensburg, the parish seat, and becomes known as Main Street. Nearing the center of town, LA 10 intersects LA 37 itself, followed by LA 43 (Kendrick Street) four blocks later. LA 43 zigzags onto LA 10 for one block then turns south onto Sitman Street toward Montpelier. Outside the town limits, LA 10 intersects LA 10 Spur, an alternate route into Greensburg from the east. Heading out of St. Helena Parish, LA 10 intersects and has a brief concurrency with LA 441, a rural highway.