Nanosensors possess great potential for diagnostic medicine, enabling early identification of disease without reliance on observable symptoms. Ideal nanosensor implementations look to emulate the response of immune cells in the body, incorporating both diagnostic and immune response functionalities, while transmitting data to allow for monitoring of the sensor input and response. However, this model remains a long-term goal, and research is currently focused on the immediate diagnostic capabilities of nanosensors. The intracellular implementation of nanosensor synthesized with biodegradable polymers induces signals that enable real-time monitoring and thus paves way for advancement in drug delivery and treatment.