Moody then moved on to Tougaloo College on an academic scholarship to earn a bachelor's degree. She became involved with the Congress of Racial Equality (CORE), National Association for the Advancement of Colored People (NAACP), and Student Nonviolent Coordinating Committee (SNCC). After graduation, Moody became a full-time worker in the civil rights movement, participating in a variety of different protests such as marches and a sit-ins. Moody participated in a sit-in at a Woolworth's lunch counter in Jackson, when a mob attacked her, fellow student Joan Trumpauer, and Tougaloo professor John Salter, Jr. The mob continuously poured flour, salt, sugar, and mustard on them, as depicted in a "Jackson Daily News" photograph. Two weeks after the sit-in, Mississippi NAACP leader Medgar Evers was assassinated outside his family home in Jackson. Anne Moody was arrested in Jackson, Mississippi for attempting to protest inside of a post office with 13 others, including Joan Trumpauer, Doris Erskine, Jeanette King, and Lois Chaffee.