As a unit of the task force for Operation Deep Freeze 63 in 1962–1963, she spent 131 consecutive days in the ice. During this time, her crew witnessed the breakup of Rear Admiral Richard Evelyn Byrd's Little America III, built in 1940 and 1941. Instead of going south for the 1963–1964 season in the Antarctic, "Edisto" entered the Boston Naval Shipyard for an overhaul. Then, on June 15, 1964, she departed Boston for military resupply operations in the Arctic. While on this cruise, "Edisto" used Prince Christian Sound instead of rounding Cape Farewell, Greenland probably making her the first US naval vessel to transit this sound since in 1941. Before returning to Boston in early October 1964, she picked up some scientists in Iceland and proceeded to the waters between Greenland and Spitsbergen, Norway to carry out an oceanographic survey.