The bridge project resulted in a realignment of several highway routes in the area. A northern bypass of New Roads was constructed to link LA 10 with the bridge, and the old route through town was designated as LA 10 Bus. LA 420 and LA 981 were extended to cover the remainder of the old route on the north side of the present route. At the same time, LA 1 was re-routed onto Hospital Road, a bypass formerly designated as LA 3131, on the west side of New Roads. Its former route through town became LA 1 Bus., sharing pavement with LA 10 Bus. On the opposite side of the river, a new highway was constructed to connect the Audubon Bridge with US 61 at Starhill, and LA 10 now followed US 61 into St. Francisville. The old route of LA 10 through town was renumbered as LA 1263 for several years until being transferred to local control in 2018.