The Edisto system flows through only one major town or city, Orangeburg, the location of Edisto Gardens (on the North Fork). The river system, being blackwater throughout its entire length, flows through highly intermittent bottom swampland. During an excessively rainy season, the river will leave its main channel, with its flow basin increasing to over a mile or more of total width. The lower Edisto basin forms a crucial part of the ACE Basin, an area that encompasses its bottomlands confluence with the Ashepoo and Combahee river basins.