Varley joined Barclays in 1982, as part of the Corporate Finance Department of the then Barclays Merchant Bank. Senior appointments with the successor bank, BZW (now Barclays Capital), included Deputy Chief Executive of BZW's Equity Division and head of BZW's offices in South East Asia. In 1995 he became Chairman of the Asset Management Division and from April 1998 to October 2000 was Chief Executive, Retail Financial Services. He joined the main Barclays board on 5 June 1998 and was Group Finance Director from 2000 until the end of 2003.