Peretti designed over thirty collections for Tiffany, with works described as "revolutionary", "timeless, distinct and modern". Her process included travel to Japan, China, and Europe and drew on the work of craftsmen there in the creation of successful collections such as Bean (an abstracted lima bean-shaped pendant), Open Heart, Mesh, Bone, and Zodiac. In addition to the sterling silver, part of her signature was the use of materials such as jade, lacquer, and rattan. Modern art was an influence; she cited Alexander Calder and Henry Moore’s sculptures as inspirations for her Open Heart collection of pendant jewelry featuring an off-center heart outline. Pieces like Bone Cuff (1970) incorporated organic forms with appreciation of the human body, and were seen as bridging a gap between costume and serious jewelry. Peretti drew the shape from the bones of monks she’d seen inside a 17th-century Capuchin church near Rome during her childhood. Enduringly popular, Gal Gadot wore an 18-karat gold version in the 2020 film "Wonder Woman 1984" and Sarah Jessica Parker wore it as Carrie Bradshaw in the first "Sex and the" "City" film (2008).