In June 2009, it was announced that Lofton had been asked to play for the Boston Celtics summer league team. In the season 2009–10, Chris Lofton was signed by Spanish ACB League powerhouse, Caja Laboral Baskonia. After only a few games played, Lofton left Caja Laboral; he had previously been hospitalized with fever. Soon after, Lofton signed with another Spanish team CB Estudiantes. In November 2010, he was selected 6th overall by the Iowa Energy in the NBA D-League Draft. He has since chosen to return to Europe. In March 2011 he signed with Lokomotiv Kuban in Russia, but left the team in May 2011 by mutual agreement. In August 2011 he returned to CB Estudiantes, signing a one-year deal but finally he couldn't play with the team of Madrid until January 2012 because of his physical problems.