He returned to action on November 21, 2008, being paired against Victor Martínez in a fight for his championship and the vacant WBA Fedecentro title. Vázquez opened the fight in a slow pace, utilizing the first round as a stage to study his opponent. After the second round, Vázquez began executing the offensive more fluidly, using jabs and counterattacks to his advantage. During the second half, he continued pressuring the offensive, scoring solid combinations in the seventh stanza. Martínez improved in the ninth and tenth round, being more effective on his attack. In the following stage, Vázquez regained control of the offensive’s tempo, scoring a knockdown. This pace continued in the final round, with Martínez receiving combinations. Following one of these attacks, Vázquez connected a left hook that made Martínez fell to the canvas, unable to continue before the referee counted ten, leading to a knockout.