The University of Pittsburgh Medical Center initially leased five floors of the tower, which now serves as the institution's headquarters, in 2007. Although U.S. Steel was the largest tenant in the building at the time, to go along with this lease, the company also purchased new signs reading "UPMC" for the top of each three sides of the building. The Pittsburgh Planning Commission approved the signs. The signage cost $750,000, according to a document submitted in 2006 to the city planning commission.