The eastern subsection, for which the Autobahndirektion Nordbayern 2016 construction costs of 574 million euros stated, lies between the Main Bridge Bettingen and the intersection Biebelried. It consisted of seven planned parts. The first included a 6.5 km section of track, which began east of the Main Bridge Bettingen and was in Baden-Württemberg. Construction work began in 2014 after the planning approval decision in 2007 and was completed by the end of 2017. A two kilometers after the border beginning eleven-kilometer section to the interchange Würzburg-West was extended between June 2009 and December 2011. The expansion of the 8.0 km-long section to the junction Würzburg-Heidingsfeld took place from mid-2007 to December 2009. In the direction of travel in Frankfurt, there is a 2.0 km-long lane in the incline area.