A 1900 fire in Bloomington destroyed most of the downtown commercial district, though it stopped short of the White Building. In 1903 the Heberling Brothers purchased the pharmacy on the building's first floor. During the next year the Heberlings moved their own company, Heberling Medicinal and Extract Company, into the building. By 1910, with the Heberlings slowly occupying more and more of the building, the Bloomington Store Fixtures Company moved all operations to the S.R White Manufacturing Company plant, across the street from the White Building.