Collier was now established as a popular and distinguished actress. In January 1908, she starred with Beerbohm Tree at His Majesty's Theatre in J. Comyn's new play "The Mystery of Edwin Drood", based on Charles Dickens's unfinished novel of the same name. Later that year, she made the first of several tours of the United States. During the second, made with Beerbohm Tree in 1916, she made four silent films, including an uncredited appearance in D. W. Griffith's "Intolerance" (she can be seen being carried through the entrance to the city in the Babylonian part of the film) and as Lady Macbeth in Tree's disastrous first film interpretation of Shakespeare's "Macbeth".