Wesker returns in the sixth film, "", having betrayed Alice and killed everyone at the White House. Guided by the Red Queen, Alice returns to the Hive where Umbrella has developed a potent antivirus. In a confrontation in the Hive, Alicia Marcus fires Wesker, enabling the Red Queen to crush his legs with a blast door, trapping Wesker. Before leaving to chase Doctor Alexander Isaacs, Alice primes the detonator for the explosives she planted around the Hive and leaves it in Wesker's hand. Wesker eventually dies of blood loss, causing him to lose his grip on the detonator. Without Wesker holding the detonator, Alice's explosives destroy the Hive, killing everyone within including Alicia Marcus, the Umbrella High Command and thousands of others held in stasis.