Passing west of the village of Spraguetown, NY 40 winds north through the town of Greenwich for several miles, reaching the hamlet of Lick Springs, a small rural community several miles north of Middle Falls. Here, the route crosses into the town of Argyle, the route proceeds northeast through the town, reaching the junction with the northern terminus of CR 49 (Old State 338). Just north of this junction, the route crosses through the hamlet of South Argyle, a rural community. North of South Argyle, NY 40 continues through the farmlands, soon reaching the namesake village. Now boasting the name of Main Street, NY 40 crosses north through downtown Argyle, reaching a junction at the northern end of the hamlet with the eastern terminus of NY 197.