The Challengers, Ray Palmer, Firestorm, Una, Harley, Holly, and Mary Marvel attempt to figure out what to do about Karate Kid, who is dying from the virus. Solomon, the Monitor of Earth-8, arrives and sends everyone back to Earth. Jason leaves the group upon their arrival. Soon after, the group discovers that no one recognizes them, and that their homes and headquarters are not there. The group goes to see Dubbilex for help with Karate Kid, only to learn that he has already died. When Karate Kid's autopsy is performed, Morticoccus is accidentally released, grows and attacks the Challengers. The virus is captured by Rayner and explodes. However, it is discovered that the virus began spreading across the planet before the autopsy, causing infected humans to devolve into animalistic savages and infected animals to gain human-like traits. Una helps Buddy Blank reach his daughter's apartment and the two locate Buddy's daughter, who has been infected by the virus, and his grandson, who is immune. Una dies while protecting Buddy and his grandson from a swarm of rats, and gives Buddy her Legion Flight Ring, which he uses to take him and his grandson to Cadmus's Command D facility. The Challengers leave the reconstituted Earth-51 and return home. After witnessing Darkseid's death, Jason returns to being a solo anti-hero while Donna, Kyle, Ray Palmer and Forager, along with the Monitor Nix Uotan, reform the Challengers and watch over the other Monitors.