Following her poisoning, Supergirl departs Earth to die alone. While adrift in interstellar space, she encounters a planet under attack by monsters and she intervenes to save them, unaware that the entire planet is a trap by Brainiac. She is captured and restrained by the Cyborg Superman, but after a struggle, she manages to escape. Returning to Earth, she is sent into the past by the Oracle alongside Superman and Superboy, where she ensures that a resurrected H'el cannot save Krypton. She sacrifices the planet and her family in order to save the universe.