The first descriptions of gallstones appear to have been in the Renaissance, perhaps because of the low incidence of gallstones in earlier times owing to a diet with more cereals and vegetables and less meat. Anthonius Benevinius in 1506 was the first to draw a connection between symptoms and the presence of gallstones. Courvoisier, after examining a number of cases in 1890 that gave rise to the eponymous Courvoisier's law, stated that in an enlarged, nontender gallbladder, the cause of jaundice is unlikely to be gallstones.