Prinz began her career at SV Dörnigheim FC. She made her Bundesliga debut for FSV Frankfurt, where she played from 1993 to 1998. During that time Prinz won two Bundesliga titles and two German Cups. In 1997 and 1998 she was the Bundesliga top scorer. In 1998, she moved to local rivals 1. FFC Frankfurt, where she has had her biggest success at club level. In 13 seasons at the club, Prinz won six Bundesliga and eight German Cup titles. She also won the Bundesliga top-scorer award twice more in 2001 and 2007. Prinz won the UEFA Women's Cup three times with Frankfurt, in the 2001–02, 2005–06 and 2007–08 seasons. She also reached the final in 2004, but lost to the Swedish side Umeå IK.