In 1982, she starred opposite Dustin Hoffman in the comedy "Tootsie" (1982), playing an actress whose actor friend (Hoffman) disguises himself as a woman to further his career. For her role, she was nominated for an Academy Award for Best Supporting Actress. She then appeared in the comedy "Mr. Mom" (1983) as the wife of Michael Keaton's character, followed by a supporting role in Martin Scorsese's "After Hours" (1985). In 1992, Teri played Marge Nelson in "Mom and Dad Save the World", a sci-fi adventure family romantic comedy film.