Plusquellic was the President of the United States Conference of Mayors during 2004. Plusquellic currently serves as vice president of the International Mayors for Peace organization. He is well known as an architect of the Joint Economic Development District (JEDD) program in Ohio, and he is a member of the Mayors Against Illegal Guns Coalition, a bi-partisan group with a stated goal of "making the public safer by getting illegal guns off the streets." The Coalition is co-chaired by Boston, Massachusetts Mayor Thomas Menino, New York City Mayor Michael Bloomberg, and Columbus, Ohio Mayor Michael B. Coleman.