Isidore of Miletus and Anthemius of Tralles, the architects of the famous Hagia Sophia in Constantinople, also contributed towards mathematical theories concerning architectural form, and the perceived mathematical harmony needed to create a multi-domed structure. These ideas were to prove a heavy influence on the Ottoman architect Mimar Sinan in his creation of the Blue Mosque, also in Constantinople. Tralles in particular produced several treatises on the Natural Sciences, as well as his other forays into mathematics such as Conic Sections.