With an interest in ships and aircraft from a young age, Radford saw his first sea duty aboard the battleship during World War I. In the inter-war period he earned his pilot wings and rose through the ranks in duties aboard ships and in the Bureau of Aeronautics. After the U.S. entered World War II, he was the architect of the development and expansion of the Navy's aviator training programs in the first years of the war. In its final years he commanded carrier task forces through several major campaigns of the Pacific War.