Radwańska and her doubles partner Maria Kirilenko reached the semifinals of the 2010 Australian Open, losing to the world No. 1 pairing of Cara Black and Liezel Huber in three sets. In Indian Wells, Radwańska won her fifth straight match against Marion Bartoli, and went on to upset Elena Dementieva in the quarterfinals before losing to Caroline Wozniacki in the semifinals. Radwańska entered the 2010 Sony Ericsson Open, where she was defeated in the quarterfinals by Venus Williams. At Wimbledon, she was defeated in the fourth round by Li Na, whom she had beaten at the same stage the previous year.