Peru later starred in Richard Day's "Girls Will Be Girls" (2003) and was one of six performers featured in the Logo original stand-up comedy series "Wisecrack" (2005). She has appeared in a number of other supporting and guest-starring roles in television and film, including "Will & Grace" in 2001 and again in 2018 and 2019, "Arrested Development" in 2005 and "Twins" in 2006; the Bravo reality series "Boy Meets Boy" (2003) and "Welcome to the Parker" (2007); the police procedural drama series "Detroit 1-8-7" in 2011; the 2004 comedy film "Straight-Jacket"; and a 2007–2008 web series follow-up to "Girls Will Be Girls". Peru performed the voice of "Mama Hippo" in the 2006 Disney animated feature "The Wild", and later was the voice of Mother Morally Superior in a 2008 episode of the Logo stop motion animated series "". In 2004 Peru appeared in an Orbitz TV commercial that was later nominated for a GLAAD Media Award.