San Bruno Creek (Spanish for: "St. Brun") is an intermittent stream that rises on the eastern slopes of the Northern Santa Cruz Mountains in San Mateo County, California, USA. The headwaters descend a relatively steep canyon east of Skyline Boulevard in a tortuous course. Comparison of topographic maps from 1896 and 1939 illustrates the extreme modification in the lower reaches due to urban development from the rapidly expanding population. The San Bruno Creek watershed was originally settled by a tribe of the Ohlone, and later this locale was part of the Spanish missions' landholdings.