Ramesh Chandra Ghosh married Shoilobala Sen of Coochbehar. The family of Shoilobala Sen was a friend of the then Maharaja of Cooch Behar. They had 4 sons and 2 daughters. Their eldest daughter was the first female who graduated (BA) from Calcutta University in that area. One son became principal of a college at Howrah near Kolkata, two sons became physician graduating from Kolkata NRS Medical College (formerly known as Campbell Medical College), and another became Chief Architect of Calcutta and had a postgraduate qualification from the United States. One of their physician sons went to UK and married an English lady and settled there and worked in UK National Health Service and had several achievements. He is mentioned in "Who's Who Indians in Britain."