Just as it did in Leesburg, US 441 in High Springs curves to the right while a state road becomes independent, specifically SR 20, which runs west only to join US 27 as they head towards Perry, Tallahassee, and Niceville. Meanwhile, as it did with US 27 in Leesburg, US 441 joins US 41 north, but here it also serves as the northern terminus of hidden SR 45. US 41-441 crosses the Santa Fe River then runs north passing by O'Leno State Park and River Rise Preserve State Park, near which it shares a brief concurrency with State Road 18. It then runs through Ellsville, where it has another interchange with I-75 (Exit 414), just south of the western terminus of State Road 238.