"Enemy Zero" received favorable reviews from several publications. "Edge" highly praised the first of the game's three discs for offering a "suspense-ridden atmosphere" and tense encounters with invisible aliens, comparing it favorably to Ridley Scott's cult classics "Alien" and "Blade Runner". However, the magazine criticized the other discs for ruining that suspense with "space soap" themes and an almost embarrassing plot. "Electric Playground" concluded that "Enemy Zero" "is one of the best Saturn games" of the year and its "high points are the innovations, like the energy gun and the VPS, that make playing this game unlike playing any other."