Wolfe has written a major body of work for strings, from quartets to full orchestra. Her quartets, as described by "The New Yorker" magazine "combine the violent forward drive of rock music with an aura of minimalist serenity the four instruments as a big guitar, whipping psychedelic states of mind into frenzied and ecstatic climaxes." Wolfe's "Cruel Sister" for string orchestra, inspired by a traditional English ballad of a love rivalry between sisters, was commissioned by the Munich Chamber Orchestra, received its US premiere at the Spoleto Festival USA, and was released (along with her other string orchestra piece, "Fuel") on Cantaloupe Music. Written shortly after September 11, 2001, her string quartet concerto "My Beautiful Scream", written for Kronos Quartet and the Orchestre National de France (premiered in the US at the Cabrillo Festival of Contemporary Music under the direction of Marin Alsop), was inspired by the idea of a slow motion scream. "The Vermeer Room", "Girlfriend", and "Window of Vulnerability" show Wolfe's ability to create vivid sonic images. "Girlfriend", for mixed chamber ensemble and recorded sound, uses a haunting audio landscape that consists of skidding cars and breaking glass. "The Vermeer Room", inspired by the Vermeer painting "A Girl Asleep"—which when x-rayed reveals a hidden figure—received its orchestral premiere with the San Francisco Symphony. In "Window of Vulnerability", written for the American Composers Orchestra and conducted by Dennis Russell Davies, Wolfe creates a massive sonic universe of dense textures and fragile windows.