The route connects a string of small towns and cities across the Central Louisiana, Acadiana, and Florida Parishes regions of the state. It runs parallel and to the north of the busier US 190 corridor. LA 10 crosses the Mississippi River via the John James Audubon Bridge, the only such crossing between Baton Rouge and Natchez, Mississippi. The western terminus in Vernon Parish comes within of reaching the Sabine River at the Texas state line and making LA 10 a true cross-state route.