Concern over Tshabalala-Msimang's health came to the fore in late 2006. She was admitted to the Johannesburg Hospital on 20 February 2007, suffering from anaemia and pleural effusion (an abnormal accumulation of fluid around the lungs). The Department of Health approached President Thabo Mbeki, and asked him to appoint an acting minister, and on 26 February Jeff Radebe was appointed acting health minister. On 14 March 2007, Tshabalala-Msimang underwent a liver transplant. The stated cause was autoimmune hepatitis with portal hypertension, but the transplant was surrounded by accusations of heavy drinking.