In the mini series "Ultimate Mystery", an elderly wheelchair-bound Dr. Samuel Sterns, member of Roxxon Brain Trust, is transformed by a modified version of the Hulk serum gathered by Doctor Octopus in an attempt to trap his creation, a female clone of Spider-Man. She, under the alias "Dr. Julia Carpenter" is caught and nearly experimented upon, but rescued by Spider-Man. Meanwhile, Sterns injects himself with a serum, thus changing into a Hulk/Leader hybrid. Sterns is later defeated by both Spider-Woman and Spider-Man.