Radwańska started the Asian leg of the WTA calendar with the Pan Pacific Open tournament in Tokyo. As defending champion and seeded No. 2 she defeated Barbora Strýcová and Monica Puig to reach her 5th Tokyo semifinal. During her quarterfinal post match conference Radwańska stated that she felt "a little like John Isner today" while serving eight aces in overpowering Olympic gold medalist Monica Puig. In the semifinal she lost a tight three set match to Caroline Wozniacki. At Wuhan Open third-seeded Radwańska defeated Ekaterina Makarova to set up a rematch with Caroline Wozniacki. Following a two set win over Caroline Wozniacki, Radwańska lost a tight tree set quarterfinal match against Svetlana Kuznetsova. Radwańska continued at the China Open, the fourth and last Premier Mandatory stop of the season. Without dropping a set she defeated Wang Qiang, Ekaterina Makarova, Caroline Wozniacki, Yaroslava Shvedova, Elina Svitolina and Johanna Konta to win her second China Open title and the 20th title of her career. The 2016 China Open is Radwanska's third Premier Mandatory title. She is just the fourth player to own three or more Premier Mandatory trophies, along with Serena Williams, Victoria Azarenka, and Maria Sharapova. Radwańska next played at Tianjin Open. She beat Tatjana Maria and Evgeniya Rodina in straight sets, but withdrew from her QF match with right-thigh injury.