I-376 is signed east–west despite running north–south for nearly three-quarters of its length; however, it does run east–west through the majority of Allegheny County. This is because until 2009, the route's western terminus was at I-279 in Downtown Pittsburgh; it was extended west and north to I-80 to give the corridor a single route designation. Despite the route's direction, it serves as a major artery through Pittsburgh's West End, with I-79 being the primary route through Pittsburgh's North Hills. Since its 2009 extension, the route has also served as a major way to access Northeast Ohio.