Behind the third Main Crossing on the Main Bridge Bettingen the highway runs rather briefly (approximately six kilometers) through Baden-Württemberg. Shortly before Helmstadt, the highway is again six lanes and bypasses Würzburg to the south, after the triangle Würzburg-West. South of Würzburg the A 3 crosses the Main for the fourth time. The A 3 then intersects the A 7 (Flensburg-Füssen), after which the A 3 switches to four lanes. It then crosses the Main for a fifth time and continues towards Nuremberg. This section leads through the Steigerwald and has a high traffic volume. Passing Höchstadt and Erlangen, Nuremberg is bypassed to the northeast. Outside of Nuremberg, the A 3 intersects with the A 9 (Berlin-Munich) and the A 6 (Saarbrücken-Prague).