Buttrose edited "Cleo" until 1975, when she was appointed editor of the Packers' flagship magazine, "The Australian Women's Weekly" (1975–76), then she became editor-in-chief of both publications from 1976–78, before being appointed Publisher of Australian Consolidated Press Women's Division from 1978–81. In 1981 she left the Packers after their rival Rupert Murdoch offered her the job of Editor-in-Chief of the "Daily Telegraph" and "Sunday Telegraph" in 1981, making her the first female editor of a major metropolitan newspaper in Australia, a position she held until 1984; she was also appointed to the board of News Limited. She made frequent appearances on radio and TV and in 1980, her media prominence led to her becoming the subject of the song "Ita", recorded by rock band Cold Chisel, which was included on their successful "East" album.