A simplified example of the impossibility of unambiguous noise reduction: an area of uniform red in an image might have a very small black part. If this is a single pixel, it is likely (but not certain) to be spurious and noise; if it covers a few pixels in an absolutely regular shape, it may be a defect in a group of pixels in the image-taking sensor (spurious and unwanted, but not strictly noise); if it is irregular, it may be more likely to be a true feature of the image. But a definitive answer is not available.