All of the above highway routes were designated by acts of the state legislature between 1921 and 1928. The portions of the routes used by the modern LA 10 remained largely consistent up to the 1955 Louisiana Highway renumbering with the exception of former Route 22 through Allen Parish. The original highway followed the present LA 1156 through Elizabeth and then travelled along section line roads south and east into Oakdale. The present diagonal route connecting Elizabeth and Oakdale was laid out alongside an existing railroad line and opened around 1941.