Now in Clayton, NY 180 crosses northeast into a junction with NY 12. The stretch through Clayton is short and rural, before the route crosses into the town of Orleans. A distance into Orleans, the route enters the hamlet of Stone Mills, a residential community in which NY 180 serves as the main thoroughfare. North of Stone Mills, the route bends to the north, remaining a two-lane rural road through Orleans. NY 180 soon bends to the northwest, reaching a junction with the terminus of CR 12. The route soon bends northeast again, passing Grove Cemetery as it enters the hamlet of La Fargeville. Paralleling the Chaumont River, NY 180 enters La Fargeville as the two-lane Main Street.