In February 2015, it was announced that Salido would fight WBO full champion Román Martínez (28-2-2, 17KOs) on April 11 in Puerto Rico. Salido came into this fight with a perfect record of (5-0, 4 KO's) against Puerto Rican fighters. Salido lost a 12-round unanimous decision to Martínez, also losing his title in the process. Salido was knocked down twice in the fight in rounds 3 and 5 and also docked a point for low blow in round 11 as Martinez won all three judges scorecards, who had it at 114-111, 115-110 and 116-109.