Hume has become known for depicting everyday subjects using high-gloss industrial paints. His earliest notable works are his "door paintings", life-size representations of hospital doors. These proved a critical success, being shown in Germany and the United States, as well as attracting the attention of collector Charles Saatchi. Hume's work was included in the 1995 exhibition "Brilliant!", a showcase of work by YBA artists. In 1997, his work was included in "Sensation", a touring show of the Charles Saatchi art collection at the Royal Academy, London.