Guitarist Jeff Loomis revealed in an interview that "This Godless Endeavor" is not a concept album but a "topic-to-topic" album, with all the songs dealing with "real life issues" that can "allegorically refer to the loss of identity, the system that we roove in, the meaning of life, the denouncement of God as a solution to all the problems that are caused by the conflicts that all the religions have initiated in various parts of the world. It's basically about human beings."