The chief cause of cork taint is the presence of the chemical compounds 2,4,6-trichloroanisole (TCA) or 2,4,6-tribromoanisole (TBA) in the wine, which in many cases will have been transferred from the cork, but which also can have been transferred through the cork rather than from it. TCA is a compound which does not occur naturally. It is created when some fungi are treated with chlorinated phenolic compounds, which are a type of antimicrobial agent used in the processing of wood. This compound is one of the chief factors responsible for the problem associated with mold liable to be found in cork. Very small amounts of this compound, on the order of nanograms, can be responsible for this defect. Corked wine containing TCA has a characteristic odor, variously described as resembling a moldy newspaper, wet dog, damp cloth, or damp basement. In almost all cases of corked wine the wine's native aromas are reduced significantly, and a very tainted wine is quite unpalatable, although harmless. While the human threshold for detecting TCA is measured in the single-digit parts per trillion, this can vary by several orders of magnitude depending on an individual's sensitivity. Detection is also complicated by the olfactory system's particularly quick habituation to TCA, making the smell less obvious on each subsequent sniff.