On the Zoo TV Tour, "Desire" was re-invented with different effects on the Edge's guitar, and it opened most encores. Bono would use the song to accentuate characteristics of his onstage alteregos Mirrorball Man and MacPhisto. On the PopMart Tour, Bono and the Edge would play the song acoustically. For the Elevation Tour, it was a stripped-down electric version played at the tip of a heart-shaped walkway that extended into the audience. Adam Clayton would join in with bass just before the bridge, and Larry Mullen, Jr. played along on a single drum.