On 22 June 1921, "Kane" rescued an Italian torpedo boat drifting upon the rocks off Cape Spartivento. On 3 July, she reached Constantinople for relief work in Turkish waters. She returned to Newport 23 August. She sailed 2 October with Destroyer Squadron 14 to evacuate refugees and perform other relief work in Asia Minor. She arrived in Constantinople 22 October, and was constantly used to carry supplies, medical aid, refugees and relief officials between ports of the Black Sea and the Eastern Mediterranean. She departed Constantinople 18 May 1923, and spent the next five years with the Scouting Fleet operating along the United States East Coast and in the Caribbean. She departed New York 13 February 1925 for a fleet training cruise to San Diego, California, and from there she sailed to Pearl Harbor and returned 17 July. In the spring of 1927 the destroyer patrolled off bandit-plagued Nicaragua and the Honduras. She decommissioned in the Philadelphia Navy Yard 31 December 1930.