The road moves away from the freight line north of SR 423, but in Lockhart it runs over a bridge for that line again between Rose Avenue and Beggs Road. Further northwest it runs beneath an interchange with State Road 414, then cuts through a corner of Seminole County and re-enters Orange County in Apopka where it meets the northern terminus of West Orange Trail and the tolled State Road 429 before leaving the Orlando area. This road was intended to be part of the Central Florida GreeneWay loop around the Orlando Metropolitan Area. The road cuts through Plymouth and back to Apopka again, but the last sites in Apopka are Orlando Apopka Airport along the west side and Zellwood Cemetery on the east side before entering Zellwood, Florida. Intersections here include Ponkan Road and then Jones Avenue which lead to another airport known as Bob White Field The road takes a slight reverse curve before the intersection with Sadler Avenue (CR 448), and then approaches Lake Ola in Tangerine, where the road turns straight north. At the junction with County Road Old 441 (former State Road 500A), US 441 finally loses its designation as the Orange Blossom Trail, then crosses the Orange-Lake County Line and enters Mount Dora. CR Old 441 remains a local downtown street in Mount Dora, but US 441 continues as a rural at-grade four-lane divided highway, with the exception of an un-numbered diamond interchange with State Road 46 and CR 46.