James Clark and William Wells first settled in the area in 1795. Although they had to leave for a while due to Native American attacks in the area, they returned between 1797 and 1800. Wellsville was founded in 1797 by William Wells, a Pennsylvanian, and former justice of the Territory Northwest of the River Ohio. Wellsville's first school and church were also established before 1800. A barn built in 1807 by the Aten family was moved to Hale Farm and Village in Bath, Ohio.