Enzinas left his wife and newborn daughter in England at the end of 1549 to print Spanish translations of Lucian, Livy, and Plutarch. The reasons are not difficult to understand: his primary interest was publishing Spanish literature, and he knew and trusted the Continental printers more than any in England. In June 1550 his family joined him in Strasbourg. There he built what was effectively a small Spanish publishing house, which for the next two and a half years produced editions of classical works and Old Testament books in Spanish. A second daughter was born in 1551.