The Scottish Reserve League merged with the Scottish C Division (third tier) for the 1949–50 season creating two regionalised divisions (South/West and North/East) with Clyde entering a reserve team in the South & West region. The club was crowned champions in 1949–50 and they retained their title in 1950–51. Despite successive titles, there was no promotion as only first teams could gain promotion to Division B. As reserve teams got excluded from the Scottish League Cup, the C Division had their League Cup. Clyde couldn't quite match the success in the cup that they had in the league as they never won the competition. The best they could manage were semi-final appearances in 1951-52 and in 1953–54.