The station is one of two western termini for the "Empire Builder," Amtrak's major long-distance train to the Pacific Northwest. The train splits at Spokane, with one section continuing to Portland by way of the Columbia River Gorge and the other continuing to Seattle. It is also a stop for the Seattle-Los Angeles "Coast Starlight," Amtrak's long-distance West Coast train. It serves as the southern terminus for two daily "Cascades" trains from Vancouver, British Columbia and four daily "Cascades" trains from Seattle, and the northern terminus for two "Cascades" trains from Eugene.