Chalke was signed by former "Scrubs" executive producer Bill Lawrence to play the love interest of Bobby Cobb in the series "Cougar Town". She appeared in multiple episodes in the third season. Chalke starred in the ABC comedy series "How to Live with Your Parents (For the Rest of Your Life)", which premiered April 3, 2013, and which was cancelled one month later. She played Polly, a single and very uptight divorced mother who found herself moving back in with her parents (Elizabeth Perkins and Brad Garrett) because of the economic downturn. Also in 2013, she played a frantic mother named Casey Hedges in the "Grey's Anatomy" season 9 episode "Can't Fight This Feeling". Chalke also voices Beth on the show "Rick and Morty".