The work itself came to be highly revered as a scholarly medical text and was seriously discussed until the 19th century. Various editions and versions of the Regimen circulated throughout Europe, many with commentaries that added or removed material from the original poem. During this interval, the Regimen was expanded from the original 364 lines to 3,526 hexameter verses. The first English translation was made by Sir John Harington in 1608. An attempt to make a medically accurate translation was made in 1871 by the American doctor John Ordronaux.