He appeared in films "The Heart Specialist" (2006) and "" (2010). In 2008, he made a cameo appearance in Estelle's music video for her single with Kanye West called "American Boy". In 2009, Jenkins appeared on E!'s reality television series "Kourtney and Khloé Take Miami", a spin-off series of "Keeping Up with the Kardashians" starring Kourtney and Khloé Kardashian. He co-hosted the radio show "Khloé After Dark" on Y100. Jenkins portrayed DJ Dave in the musical film "Burlesque" (2010) starring Christina Aguilera and Cher. In 2011, he had a recurring role as Danté Young on the BET comedy-drama television series "The Game". On September 4, 2012, Jenkins was named the co-anchor of E! News, replacing Ryan Seacrest.