Twenty-seven years after the start of the quarantine, a group of armed police officers discover several people in London infected with Reaper virus during a routine investigation. Prime Minister John Hatcher shares satellite footage of survivors in Scotland with domestic security chief Captain Nelson. Believing a cure may exist, Hatcher orders Nelson to send a team into Scotland to find medical researcher Dr. Kane who was working on a cure when Scotland was quarantined. Nelson chooses his top police officer, Major Eden Sinclair, to lead the team. Sinclair is originally from Scotland, having escaped as the quarantine began at the cost of her right eye. For Sinclair the mission is also personal, as she hopes to learn if her mother survived or not.