From Junction, US 190 heads east to DeRidder, where it runs concurrently with US 171 south and passes several sites on the National Register of Historic Places, such as the Beauregard Parish Jail, Beauregard Parish Courthouse, and the DeRidder Commercial Historic District. US 190 runs concurrently with US 171 to Ragley, where US 190 parts with US 171 heading east. From Ragley, the two-lane highway heads nearly due east almost parallel to I-10 until Opelousas. US 190 crosses the northern reach of the Atchafalaya Basin near the Morganza Spillway en route to Baton Rouge. From Baton Rouge, US 190 passes, in places divided, through Denham Springs, Albany, Hammond, Robert, Goodbee, Covington, Mandeville, before reaching the eastern terminus at Slidell.