In 2006, Guillory was a lead in the ensemble cast of the fantasy "Eragon," the film adaptation of the novel by Christopher Paolini; the role reunited her with "The Time Machine" co-star Jeremy Irons. She portrayed Arya Dröttningu, an elf princess. She had not read the novels before filming, but after accepting the role she became a fan of Paolini's work. Although Arya is a key character in the film, Guillory had little screen time and went on to say jokingly: "I've been trying to explain to friends who've seen the trailer [...] I'm like, "[...] but that's my whole part!"" "Eragon" was not well received by the critics, but was nominated as Best Fantasy Film at the 2006 Saturn Awards. The film grossed approximately $75 million in the US and $173.9 million elsewhere, totaling $249 million worldwide. Guillory was invited to reprise her role as Jill Valentine in "", the sequel to "Resident Evil: Apocalypse," but could not accept due to scheduling conflicts with "Eragon."