Continuing with the rural surroundings, US 441 maintains its straight north and south position until it curves to the northwest between Lincoln and East Pine Avenues. Approaching Loch Leven, it turns straight west, and then State Road 44 joins US 441 after having run west from New Smyrna Beach and DeLand. This intersection is also shared with County Road 44B, which takes motorists to Downtown Mount Dora. In southern Eustis, US 441-SR 44 encounter another un-numbered interchange with State Road 19 and County Road 19A, taking SR 19 in a wrong way concurrency until it reaches a wye in Tavares, where SR 19 heads south toward Howey-in-the-Hills and Groveland, and County Road Old 441 rejoins US 441. From here, US 441-SR 44 is a six-lane highway with bicycle lanes that squeezes between Lake Harris and Lake Eustis where it crosses over the Dead River on a bridge between the two lakes. The road passes by Leesburg Municipal Airport, then serves as the western terminus of County Road 44, all the while winding around the northern shores of Lake Harris. In Leesburg, SR 44 leaves US 441 heading toward Wildwood, Inverness, and Crystal River, while US 441 curves to the northwest, then intersects U.S. Route 27 in another concurrency, and as a result, the hidden state routes are officially SR 25-500. The concurrency with SR 25 is short-lived, because in Lady Lake, SR 25 branches away as County Road 25. This once served as the southern terminus of the US 27-441 Alternate Route around Lake Weir into Belleview, but still remains a scenic route.