On 5 August 2010, de Marco underwent an angioplasty to widen an obstructed heart artery. The intervention developed complications which led him to a critical, but stable condition. A series of medical bulletins were issued immediately by the medical team at Mater Dei Hospital, stating that De Marco was responding to treatment and showing signs of improvement. His condition continued to improve by the hour, to the extent of being taken off life-support machines. Five days later he was discharged from Mater Dei Hospital, but monitored closely by the medical team.