Khoury was born in Mazraat Al Toufah, Zgharta District, Lebanon into a Maronite Christian family. He is the third of five children born to Tanyous and Naseema Khoury. He has two older sisters, Leena and Mona, and two younger brothers, Claude, who works as a TV director, and Dany, a music arranger. In 1986, Khoury enrolled at the Université Saint-Esprit de Kaslik (USEK) in Lebanon where he studied piano, Musicology and Music History. During his university years, he won a prize in a music composition contest. The award was presented to the singer by former Lebanese President Amin Gemayel. On his first album, "Kasak Habibi" (كاسك حبيبي), which was released in 1988, Khoury wrote, composed, and produced all of the songs himself.