Van der Kuijlen was born in Helmond and started his youth career at local club HVV. In 1964, he was signed by PSV. Van der Kuijlen ended up playing for the club 18 years, winning three Eredivisie titles, two domestic cups and the UEFA Cup in 1978. He was also crowned Eredivisie top scorer three times. After short periods with MVV Maastricht and Overpelt, he retired at age 37. After his playing career, Van der Kuijlen returned to PSV as assistant manager, first team coach, youth coach and scout. He also briefly served as assistant manager at Roda JC.