In 1845, Rev. Shuck returned to the United States to search for another wife, as well as raise funds for a chapel in Canton. Their sons Ryland Shuck (1837–1912) and Lewis Hall Shuck (1836–1911) also returned to be raised by their grandfather in Lancaster County, Virginia. Rev. Shuck also brought Yong Seen Sarng, with whom he toured the United States, speaking to various Baptist mission groups, including the newly formed Southern Baptist Convention. Sarng became a sensation in Richmond. The First Baptist Church of Richmond paid for his return journey, and sent him with warm clothing and a year's salary; they corresponded for many years. Rev. Lewis Shuck remarried, to Elizabeth Sexton, who died in China in 1851. Rev. Shuck established a Baptist Mission in Shanghai, and later worked among Chinese immigrants in California, establishing a Chinese-speaking Baptist church in San Francisco in 1855. He retired to Barnwell, South Carolina where he died at age 49 and was buried in 1863.