In Home's 'Agis' on 21 Feb. 1758 Mrs. Pritchard was the first Agesistrata, and in Arthur Murphy's "Desert Island" on 24 Jan. 1760 the first Constantia. On 3 Jan. 1761 she was the original Queen Elizabeth in Brookes's 'Earl of Essex,’ and on 12 Feb. the original Mrs. Oakly in Colman's "Jealous Wife". On 11 Dec. she was the first Hecuba in John Delap's "Hecuba". In Mallet's "Elvira" on 19 Jan. 1763 she was the first Queen, and in Mrs. Sheridan's "Discovery" on 3 Feb. the first Lady Medway. On 10 Dec. she was the original Mrs. Etherdown in Mrs. Sheridan's "Dupe". The same season saw her act Roxana in the "Rival Queens". For her benefit on 15 March 1766 she had an original part in Charles Shadwell's "Irish Hospitality", and on 12 April was the first Dame Ursula in William Kenrick's "Falstaff's Wedding". On 5 Dec. 1767 she played her last original part, Mrs. Mildmay, the heroine of "The Widowed Wife" of Kenrick. During the season of 1767–8 she gave a series of farewell performances, her last appearance taking place on 24 April 1768 as Lady Macbeth, when she spoke an epilogue by David Garrick. Another epilogue by John Keats, written for the same occasion, but unspoken, appears in his poems.