For the Apertura 2016 season, Tigres signed Argentine forward Ismael Sosa and their second French striker Andy Delort. On 10 July 2016, Tigres won the 2016 edition of the Campeón de Campeones Cup against Pachuca FC by 1–0 at the StubHub Center in Carson, California. Tigres finished the Apertura 2016 regular season in third place with 30 points and tied with Tijuana as the best defense, allowing 13 goals in 17 games. In playoffs, Tigres tied the first leg of quarterfinals in Mexico City against UNAM by 2–2. In the second leg, Tigres beat UNAM by 5–0 at the Estadio Universitario with a hat-trick of Gignac. At semifinals, Tigres faced León. In the first leg, Tigres won by 1–0 with a goal of Gignac after a cross from Ismael Sosa at the Estadio León. In the second leg, Tigres achieved a home victory of 2–1 with goals of Gignac and Zelarayán. In the finals against América, the teams tied 1–1 in the first leg at Estadio Azteca, Gignac scoring for Tigres. In the historical second leg played for the first time on 25 December, the teams tied 0-0 and went to overtime at the Estadio Universitario. At 95' Edson Álvarez scored the 1-0 for América and at 118' Jesús Dueñas tied dramatically and led the match to a penalty shoot-out. Nahuel Guzmán stopped three shots and with Gignac, Juninho and Guido Pizarro scoring their own, Tigres became the Apertura 2016 champions.