The church was built to replace the Old St. Augustine Church which was completed in 1801. The first Order of Hermits of St. Augustine church founded in the United States, the original St Augustine housed the Liberty Bell's "Sister Bell". The church was burned down in the anti-Catholic Philadelphia Nativist Riots on May 8, 1844. The church sued the city of Philadelphia for not providing it with adequate protection. The money awarded to the church went to rebuilding the current church, which broke ground on May 27, 1847. Organizations founded by the church led to the creation of both Villanova University and the Philadelphia Orchestra.