After initially getting EC assignments to illustrate romance comics, he soon became one of the most prolific EC artists, drawing crime, horror, humour, suspense and science fiction stories. He was known for his drawings of attractive women. Describing Kamen's understated style, EC editor Al Feldstein said, "We gave Kamen those stories where the All-American girl and guy are married and then chop each other to pieces." In "Tales from the Crypt" #31, Kamen drew a semi-autobiographical self-satire, "Kamen's Kalamity", later adapted to HBO's "Tales from the Crypt" TV series as "Korman's Kalamity". The story depicted the transition from romance to horror by Kamen, who called it "my favourite story".