Comstock made engravings for the more than 600 plates used in the "Manual for the Study of Insects" (1895), "Insect Life" (1897), and "How to Know the Butterflies" (1904), the first written by her husband and the latter two co-authored by them. Her engravings appeared in the World's Columbian Exposition in 1893, the Paris Exposition Universelle in 1900, and in the Pan-American Exposition in Buffalo in 1900. She was the third woman to become a member of the Society of American Wood-Engravers, and has been recognized as its most prolific producer of original (as opposed to reproductive) images.