His marriage to his next wife, Ann Wickett, an American and a co-founder of the Hemlock Society, ended in 1989 when she filed for divorce; they had no children. Ann Wickett committed suicide, at the age of 49 on 2 October 1991, during a recurrence of depression. She had been battling breast cancer, but the cancer was in remission and she was not considered "terminally ill". In her suicide note, she claimed that Humphry was a "killer" and that his first wife, Jean, had died of suffocation. He denied these allegations as groundless.