After returning from the DL, Holliday's first home run was a grand slam on July 21 against Carlos Rodon of the Chicago White Sox in an 8–5 win, his sixth career grand slam. He reinjured the right quadriceps on July 30, prompting the club to retract him to the DL. The Cardinals reactivated him on September 15 after missing 41 games. Holliday played 73 games and finished the season with a .279 batting average, .394 on-base percentage, .410 slugging percentage, .804 OPS, four home runs and 35 RBI in 277 plate appearances.