Sanchez once again put up the only points for the offense in another humiliating blowout, this time a 45–14 loss to the Detroit Lions. Sanchez played relatively well, avoiding a 3-and-out on the first drive with a 5-yard scramble and managing to tie the game 7–7 with a touchdown pass to Brent Celek, but a defensive meltdown and lack of offensive momentum left the Eagles hopeless, and Sanchez finished his Eagles record with an 0–2 record as starter. Sanchez finished 19/27 for 199 yards with 2 touchdowns and no interceptions, which translated into a passer rating of 116.1.