Ahead of the 2010–11 season, Culio, once again, expressed his desire to leave the club. Despite the move never happened, he, nevertheless, helped the side beat Unirea Urziceni in the Supercupa României, after the match went on penalties following a 2 –2 draw throughout extra time. He started the season as a first team regular for the side. On 2 August 2010, Culio scored his first goal of the season, in a 2–0 win over Victoria Brănești. In a 2–1 win over FC Basel in the UEFA Champions League Group Stage Matchday 1, he set up two goals, in which he was praised for his performance. Culio then assisted three times in three matches between 24 September 2010 and 3 October 2010. Then, on 19 October 2010, he scored his second league goal of the season, in a 3–2 loss against Bayern Munich. A month later, on 28 November 2010, he scored again, in a 2–2 draw against Steaua București. By the end of December 2010, Culio was subjected of a transfer bid by Kuban Krasnodar, which was rejected by the CFR Cluj. By the time of his departure, he made twenty–five appearances and scoring three times in all competitions. He also finished the top assists for the Champions League Group.