The original production of "Sex" was directed by Edward Elsner, produced by C. William Morganstern, and stage managed by Alfred L. Rigali. The original cast featured Mae West as Margy LaMont, Al Re Alia as Curley, Conde Brewer as Condez, Gordon Earle as Waiter, D. J. Hamilton as Jones, Frank Howard as Jenkins, Michael Markham as Spanish Dancer, Constance Morganstern as Marie, Mary Morrisey as Red, Barry O'Neill as Lieutenant Gregg, Ann Reader as Agnes Scott, Pacie Ripple as Robert Stanton, George Rogers as Captain Carter, Warren Sterling as Rocky Waldron, Eda Von Buelow as Clara Smith, and Lyons Wickland as Jimmy Stanton.