He married on 27 December 1714 Anna Maria, daughter and co-heiress of John Gumley of Isleworth, commissary general to the army who was often satirized by the wits of the day ("Notes and Queries", 3rd S. iI. 40 2-403, ~ 490). She died on 14 September 1758, and their only son William Pulteney died unmarried at Madrid on 12 February 1763. Pulteney's vast fortune passed in 1767 to Frances, wife of William Johnstone and daughter and co-heiress of his cousin, Daniel Pulteney, a bitter antagonist of Walpole in parliament, and had taken the name of Pulteney.