During a sermon the day after he was attacked in the bar, Jesse was suddenly struck by a supernatural force later identified as Genesis, grafting itself to Jesse's soul and releasing an explosion of energy that destroyed the church and the town, killing the whole population. By a well-timed coincidence, Tulip had hitched a lift with an Irishman named Cassidy after having just bungled her first job as an assassin. The two discovered Jesse among the rubble of the church and, after some discussion, agreed to help him to safety, although Tulip was still furious with Jesse over his sudden abandonment of her five years before. The death of the townsfolk and the rumored appearance of a stone-faced, dual-pistol wielding cowboy brought the involvement of both local law enforcement and the FBI.