In the major leagues, Zimmer remained with the Los Angeles Dodgers after their move west in 1958. In 1960, the Dodgers traded Zimmer to the Chicago Cubs for Johnny Goryl, Ron Perranoski, Lee Handley and $25,000. After the 1961 season, the expansion New York Mets chose Zimmer from the Cubs as the fifth pick in the premium phase of the 1961 Major League Baseball expansion draft, costing the Mets $125,000. In May 1962, the Mets traded Zimmer to the Cincinnati Reds for Cliff Cook and Bob Miller. He returned briefly to the Dodgers in 1963, when the Reds traded him to the Dodgers for Scott Breeden. The Washington Senators purchased Zimmer from the Dodgers in June 1963. The Senators released Zimmer after the 1965 season, and he played for the Toei Flyers of Nippon Professional Baseball in 1966.