In 2010, Harris was benched after the second week of the season. Head coach Lovie Smith stated, "We have 45 guys that you can go with; we have everybody healthy right now. Just felt like we wanted to get a look at Marcus Harrison, him and Henry Melton inside, a little bit. Just performance based. Tommie's been doing everything we've asked him to do." The same week, former defensive tackle Warren Sapp criticized Harris, comparing him to "blind dog in a meat house." Harris returned to the Bears the next week, but lost his starting position. He recorded his only sack of the season in week 17 against the Green Bay Packers.