WIS 110 joins the two highway five miles east of Waupaca, and WIS 54 turns east off the route two miles (3 km) northeast of that point to continue following the river. WIS 22 and WIS 110 pass through Manawa and junction with WIS 161 west four miles (6 km) north of the city. WIS 110 continues north at that point while WIS 22 turns east and passes through the small community of Symco. WIS 22 turns north onto US 45 where WIS 76 begins nine miles (14 km) east of Symco. WIS 22 continues north along US 45 for then splits north while US 45 turns west in Clintonville. The western terminus of WIS 156 connects with the route one mile (1.6 km) north of the US 45 junction. WIS 22 passes through Embarrass on the Shawano County line.