Born in Lyallpur (Faisalabad), Khan had his first public performance at the age of 15, at his father's chelum. He became the head of the family qawwali party in 1971. He was signed by Oriental Star Agencies, Birmingham, England, in the early 1980s. Khan went on to release movie scores and albums in Europe, India, Japan, Pakistan and the U.S. He engaged in collaborations and experiments with Western artists, becoming a well-known world music artist. He toured extensively, performing in over 40 countries. In addition to popularising qawwali music, he also had a big impact on contemporary South Asian popular music, including Pakistani pop, Indian pop and Bollywood music.