St. Mary's was founded by twelve sisters from the Sisters of the Holy Names of Jesus and Mary in 1859, at the request of archbishop François Norbert Blanchet. Only two of the sisters spoke English; the others spoke French. They traveled from Montreal via ship and rail to Fort Vancouver where Blanchet had established a school on property he purchased from Daniel H. Lownsdale in 1857. The property had a two-story house, which became the school. St. Mary's opened in the same location with six female students (three Catholic, two Jewish, one Protestant) on Monday, November 7, 1859, 17 days after they reached Portland.