The Guarneri began touring almost immediately, with a concert in Cleveland on 20 April 1965. In the summer of that year they embarked upon their first European tour, performing in Geneva, Basel, Amsterdam, Cologne, and at the Festival of Two Worlds in Spoleto, Italy. As the quartet's reputation grew, both domestic and international tours became a way of lifeoften a grueling one. In the early years they played as many as 130 concerts per year, although by the 1980s they were attemptingnot always successfullyto limit their appearances to 100 per year.