On October 27, Sanchez started for the final time in place of the injured Booty, an away game against Oregon at Autzen Stadium. USC lost, 24–17; Sanchez had two passes intercepted by Oregon safety Matthew Harper in the second half. The first interception led to a fourth-quarter touchdown that gave Oregon a 14-point lead; the second interception ended USC's final chance for a comeback. In spite of a myriad of mistakes committed by his teammates in addition to his own, Sanchez publicly accepted blame for the loss. The following week, against Oregon State, Booty returned as USC's starting quarterback, with Sanchez resuming his position as Booty's backup. Sanchez did not perform in subsequent games and finished the season with 695 yards and seven touchdowns with five interceptions.