In his Daxamite iteration, he shares the race's genetic vulnerability to terminal lead poisoning. In his Kryptonian iterations, he is vulnerable to kryptonite. In both iterations, he is vulnerable to the radiation of a red sun which cancels out the yellow solar radiation flourishing in his cells and subsequently neutralizes his abilities. His virtual invulnerability offers no protection against mind control or magic nor can it withstand the force of several atomic bombs without causing him sufficient injury; he is also vulnerable to opponents of superior strength such as Doomsday nor can he outrun Speedsters such as the Flash.