He joined Parmenion in advising Alexander the Great not to set out on his Asiatic expedition until he had provided by marriage for the succession to the throne. On the king's departure in 334 BC, he was left regent in Macedonia and made "general ("strategos") of Europe", positions he held until 323 BC. The European front was to prove initially quite agitated, and Antipater also had to send reinforcements to the king, as he did while the king was at Gordium in the winter of 334–333 BC.