From the end of May to the start of August, "Vendetta"s division was assigned to the Tobruk Ferry Service: supply runs to the Allied forces besieged at Tobruk. During the evening of 10–11 July, "Vendetta" and the destroyer were returning from a run to Tobruk when the British destroyer was crippled by aerial bomber attacks. "Vendetta" took on board the soldiers and equipment "Defender" was carrying, and attempted to tow the ship to Alexandria. On the morning of 11 July, it was decided that salvaging the ship was unachievable, and after taking the crew aboard, "Vendetta" torpedoed "Defender" at 11:15. "Vendetta" performed twenty return voyages to Tobruk: the greatest number by a ship assigned to the supply run. On 20 October, the destroyer concluded service in the Mediterranean, and sailed to Singapore for refit.