Blundell has received numerous awards and medals, including the Alcon Award for Vision Research in 1986; Gold Medal, Institute of Biotechnology in 1987; Krebs Medal FEBS 1987; Ciba Medal, Biochemical Society in 1988; Feldberg Prize in Biology and Medicine in 1988; Gold Medal, Society of Chemical Industry in 1996; First Recipient, Pfizer European Prize for Innovation in 1998 and Bernal Lecture, Royal Society 1998. Most recently he received the 2013 Biochemical Society Award and Cambridge University Science Prize called the Philosophical Society Fellows Prize & Lecture 2014. He has been President, UK Biosciences Federation (2003–2009); President, Biochemical Society (2009–2011); and President, UK Science Council (since 2011).