A large portion of the route, including the concurrency with NY 107, is a multi-lane, divided highway. It runs through both the relatively dense, middle-class suburbs of southern and central Nassau County and the affluent, sparsely populated suburbs of the north shore. Along the way, it accesses the Hicksville Long Island Rail Road station and the Broadway Mall, also in Hicksville. At a point north of NY 25A, the road narrows from four to two lanes on its way to Oyster Bay. South of the route's terminus at NY 105, a junction which is also that route's western terminus, Newbridge Road continues to Bellmore as County Route 106 (CR 106), an unsigned county road. NY 106 was assigned as part of the 1930 renumbering of state highways in New York.