Activated at Amarillo AFB, Texas, in 1963, the 461st absorbed the personnel and equipment of the inactivating 4128th Strategic Wing. Trained with B-52s to-maintain heavy bombardment proficiency, and participated in numerous-operational readiness inspections and actual and simulated exercises as directed by the Strategic Air Command. Deployed B-52 aircraft and crews to Andersen AFB, Guam, 18 January – 4 July 1967, for combat operations in Southeast Asia. Maintained combat proficiency until 21 January 1968 when last B-52 transferred. Inactivated on 25 March.