In 2020, the nuclear genome was generated of a 33,000 YBP Pleistocene wolf from an archaeological site on the Yana River, arctic northeastern Siberia. The Yana wolf sequence was more closely related to the 35,000 YBP Taimyr wolf than it was to modern wolves. There was evidence of gene flow between the Yana-Taimyr wolves and the Pre-Columbian, Zhokhov, and modern sled dogs. This suggests that genetic admixture has occurred between the Pleistocene wolves and the ancestor of these dogs. There was no evidence of admixture between sled dogs and the modern grey wolf for the past 9,500 years. Greenland sled dogs have been kept isolated from other breeds since their arrival in Greenland with the Inuit people 850 years ago. Their lineage traces more genomic history to the Zhokhov dogs than any other arctic breed. Sled dogs do not show an adaptation to a starch-rich diet when compared with other dogs but do show an adaptation to a high intake of fat and fatty acids, which was not found in the Zhokhov dogs. The same adaptation has been found in Inuit and other arctic peoples. This suggests that the sled dogs adapted to the low starch and high fat diet of the people they coexisted with.