NY 106 begins at an intersection with NY 105 (Jerusalem Avenue) in the North Bellmore section of the town of Hempstead. The route proceeds northward as a four-lane arterial, passing some businesses before entering exit 25 of the Southern State Parkway. The route merges down to two-lanes after the interchange, becoming a residential street known as Newbridge Road. NY 106 bends northeastward after East Meadow Avenue (CR 144), before intersecting with North Jerusalem Road (CR 181). The route bends northward once again, expanding to four-lanes through Hempstead. After a short commercial stretch, NY 106 becomes residential once again, becoming a divided highway after the intersection with Bush Street.