The management of "R. microsporus" can be either complete sterilization, antifungal use, or the blocking of sporulation so it cannot spread. This fungal-bacterial symbiont is classified as a biosafety level 2 organism. A common method of sterilization is getting rid of all of the reproductive structures of the fungus. More difficult sterilizations oftentimes requires control agents such as antifungals are employed. However, "R. microsporus" is also naturally resistant to fluconazole, ketoconazole, voriconazole and the echinocandins. Antifungal prescription drugs that usually will control "R. microsporus" are amphotericin B and triazoles such as posaconazole, it’s also occasionally susceptible to itraconazole.