In both tournaments of the 2019 season, América displayed a solid performance. In the Apertura tournament, the team placed fourth in the first stage and third in their semi-final group, behind eventual runners-up Deportivo Pasto and tournament favourites Millonarios, whom they beat on the last matchday thus preventing them from advancing to the final. They eventually won their fourteenth domestic league title and first in 11 years in the Finalización tournament. Under the guidance of manager Alexandre Guimarães and led by strikers Michael Rangel and Duván Vergara, with the former becoming one of the tournament's top scorers, the team placed second in the first stage and topped their semifinal group ahead of crosstown rivals Deportivo Cali, Santa Fe, and Alianza Petrolera. In the final, "Los Diablos Rojos" faced Junior, whom they beat 2–0 on aggregate score over two legs to win the championship and secure a return to the Copa Libertadores for its 2020 edition.