On September 24, 2006, he caught a 75-yard touchdown pass from Brett Favre against the Detroit Lions. It was Favre's 400th touchdown pass for his career, a milestone reached only by Favre, Dan Marino, Peyton Manning, Tom Brady, Drew Brees, Philip Rivers and Aaron Rodgers. This was also Jennings's first 100-plus-yard game, as he finished with 3 catches, 101 yards and 1 touchdown. Jennings was voted NFL Rookie of the Week for games played September 24–25, 2006, the only time he received this honor. Jennings was also named to the NFL All Rookie team at the end of the season.