During the last part of its eastbound ascent, it becomes known as the Admiral Peary Highway from Armagh, Pennsylvania in Indiana County through the Blair Gap and down into the Altoona area. From Duncansville to Mount Union, US 22 is a two-lane road with occasional passing and truck-climbing lanes, and it passes through the business district of Huntingdon, where it is three lanes (one lane each way with a turning lane in the middle). It becomes concurrent with US 522 near Mount Union and remains a two-lane road. The US 522 concurrency continues until Lewistown. US 22 bypasses the downtown area of Lewistown as a four-lane limited access highway and becomes concurrent with US 322, continuing as a four-lane limited access highway along the Juniata and Susquehanna rivers until Harrisburg. In Harrisburg (with the US 322 concurrency ending at I-81), it continues as N Cameron Street, Arsenal Blvd., Herr St., Walnut St., Jonestown Rd., and Allentown Blvd. In Fredericksburg, US 22 becomes concurrent with I-78 for a stretch before splitting off on to the Lehigh Valley Thruway.