At the end of the 2005 season, Boston traded Sánchez along with Hanley Ramírez, Jesús Delgado, and Harvey García to the Florida Marlins, in the same transaction that brought Josh Beckett, Guillermo Mota, and Mike Lowell to the Red Sox. In addition to Beckett and Lowell, the Marlins traded several of their other star players after the 2005 season, including Carlos Delgado, Juan Pierre, Paul Lo Duca, and Luis Castillo, for mainly minor-league prospects. Baseball America ranked Sánchez third in the Marlins system (after Jeremy Hermida and Ramirez) and 40th overall in the major leagues at the start of the 2006 season.