Mayagüez started the 2011 season with two losses to the Piratas de Quebradillas and the Gallitos de Isabela. Their struggles continued, but in their third game of the season, played at the Palacio de Recreación y Deportes, they finally got their first win of the season, against power house Santurce Crabbers by a final score of 80–68 to the delight of fans in attendance. By mid season, Mayagüez would again confront problems with Héctor Romero (knee injury) and Herve Laminaza (family problems). The team then signed Dwayne Jones, Sean Williams, Lee Nailon and Brandon Robinson to substitute these players. Mayagüez would be in race for the eighth and final spot of the playoffs but the team had two games confiscated and reschedule to be replayed because of an ineligible player change for Herve Laminaza. The league ruled that the substitution of Lee Nailon for Herve Laminaza surpassed the team's maximum player change and ruled that the games played by Nailon had to be played again. This determination was devastating for the team's aspirations for the playoffs as they lost one of those two games with the Piratas de Quebradillas and the team fell short by two games to make it to the playoffs for the second time in three seasons. Mayagüez finished with a 10-20 record in 2011.