In 1916, pre-1927 Route 2 was designated to run along the present US 130 between the Camden area and Bordentown while pre-1927 Route 1 was to follow the current route between Robbinsville and New Brunswick. The current route between Penns Grove and Westville was to become pre-1927 Route 17S in 1923. In 1926, US 130 was designated to run from US 30 in Camden to US 1 in Trenton along the alignment of pre-1927 Route 2. A year later, the alignment of US 130 became Route 25 between Camden and Bordentown, Route 39 between Bordentown and White Horse, and Route 37 between White Horse and Trenton. US 130 was extended to Pennsville in 1938 along Route 45 and Route 44 while it was realigned to follow Route 25 and Route 25M between Bordentown and Route 27 in New Brunswick by the 1940s. In 1953, the state highways running concurrent with US 130 were removed. Around the time of the renumbering, limited-access bypasses for US 130 were built around Carneys Point and between Bridgeport and Westville; the former alignments eventually became Route 44. In the 1960s, I-295 was designated onto most of these freeway alignments of US 130, which was moved back to its original route in Carneys Point. In 1969, the north end of US 130 was cut back to its current location, with the old road into New Brunswick becoming Route 171. The Delaware Valley Regional Planning Commission had proposed a US 130 freeway between Camden and Burlington, but it was never built.