In the 13th century, it was captured by the Emperor of Nicaea, Theodore I Laskaris. In 1335, the Byzantines, with the help of Ottoman forces, reconquered the island, then property of the Genoese nobleman Domenico Cattaneo. In 1355, emperor John V Palaiologos gave it to the Genoese adventurer Francesco Gattilusio, who married the emperor's sister, Maria. They renovated the fortress in 1373, and it remained in Genoese hands until 1462, when it was besieged and captured by the Ottoman sultan Mehmed the Conqueror.