Early in 1782, she sailed to the West Indies as part of Admiral Sir George Rodney's squadron, with Rear-Admiral Sir Samuel Hood as his second in command. On 9 April, the Battle of the Saintes began with an indecisive skirmish, in which the ships of the vanguard division, under Hood's command, were badly damaged and forced to withdraw to make repairs. On 12 April, "Agamemnon" took part in the second action, which proved much more decisive. Over the course of the battle, "Agamemnon" had 2 lieutenants and 14 crewmen killed, and 22 others were wounded.