The 410th BW continued to conduct strategic bombardment training and air refueling operations to meet operational commitments of Strategic Air Command. From 1964 to 1975, the wing supported combat operations over Vietnam by rotating B-52 and KC-135 flight crews to Guam and Okinawa. In 1980, two crews assigned to the 644th Bombardment Squadron of the 410th BW (S-21 and S-31) were awarded the Mackay Trophy for "executing a nonstop, around-the-world mission with the immediate objective of locating and photographing elements of the Soviet Navy operating in the Persian Gulf.