Oz married Nily Zuckerman in 1960, and they had three children. The family continued to live at Hulda until 1986, when they moved to Arad in the Negev to seek relief for their son Daniel's asthma. Oz was a full professor of Hebrew literature at Ben-Gurion University of the Negev from 1987 to 2014. He also served as a writer in residence and visiting scholar at universities abroad. In 2014, the family moved to Tel Aviv. His oldest daughter, Fania Oz-Salzberger, teaches history at the University of Haifa.