Dr. Sivana turned out to be indirectly responsible for the main conflict of "52": disruptions in the fictional time stream caused by a mutated Mister Mind. Sivana had captured Mind, a worm who happened to be another of Captain Marvel's villains, and the scientist had bombarded it with treatments of Sivana's own "Suspendium" time-travel compound. As a result, Mr. Mind mutated (or, according to himself, matured—as he had apparently been in larval form all this time) into a "hyperfly", a (sometimes) planet-sized moth-like figure with the ability to travel in time and across realities, posing a serious threat to the Multiverse. He is finally thrown back in time to the day where Dr. Sivana found him.