Following the bypass of Nenagh in 2000, and resulting realignment of the N7, the old route through the town was reclassified as part of the R445. The R445 passes through Nenagh via the "Dublin Road", "Thomas MacDonagh Street", "Pierce Street", "Kickham Street", "Ash Road" and "Clare Street". The route meets the N52 west of Nenagh. From the Carrigatogher Roundabout the R445 leaves the N52 road and continues along the old N7 route to Birdhill which was redesignated in April 2010. The route between Birdhill and Annacotty was redesignated as R445 in September 2010 following the opening of the Birdhill to Limerick section of the M7.