The cathedral was built from 1950 to 1952 by the Greek community of Houston. From 1967 to 1974, the church was the seat of the Bishop of the 8th Diocesan District of the Greek Orthodox Archdiocese of North and South America. The church provides a variety of ministries and services as well as housing a number of organizations. It is named for the Annunciation of the Virgin Mary and celebrates its feast day on March 25th. The church hosts services and also functions as part of the Annunciation Orthodox School.