Significant distances requiring transportation in Southern Arizona are generally traveled by highway and the railroad. Southern Arizona is the location of the major transcontinental Interstate highway Interstate 10 from the border with New Mexico westward through Tucson, and then continuing northwest via Casa Grande to the Phoenix–Scottsdale–Mesa metropolis. Also, running westward from Casa Grande is Interstate 8, which goes via Yuma into California, crossing the Colorado River. Finally, the short Interstate 19 runs south from Tucson to Nogales, Arizona, and a major border crossing into Mexico. In addition, the much older Federal highway, U.S. Route 80, crosses Southern Arizona from east to west from the New Mexico border, nearly to the California border, and formerly into California to the Pacific Ocean. However, its westernmost stretch has been replaced by Interstate 8, which was built on top of it and its right-of-way.