The kingdom was founded in 19 when the Surenid governor of Drangiana (Sakastan) Gondophares declared independence from the Parthian Empire. He would later make expeditions into the west, conquering territory from the Indo-Scythians and Indo-Greeks, thus transforming his kingdom into an empire. The domains of the Indo-Parthians were greatly reduced following the invasions of the Kushans in the second half of the 1st. century. They managed to retain control of Sakastan, until its conquest by the Sasanian Empire in c. 224/5.