In 2012, Del Castillo starred in the Mexican film "", which centers around the assassination of the Mexican presidential candidate Luis Donaldo Colosio. The following year, she starred in the American prison drama film "K-11". In later years, Del Castillo appeared in many American movies, including playing Idris Elba's ex in the 2014 thriller "No Good Deed", Antonio Banderas' wife in the disaster-survival drama "The 33", "All About Nina" (2018), "El Chicano" (2019), and "Bad Boys for Life" (2020). In 2017, she went to star in the Netflix political thriller series, "Ingobernable" playing the fictional First Lady of Mexico, Emilia Urquiza. The second season premiered in 2018.