The route east from Los Angeles was added to the Interstate Highway System on August 7, 1957. It was assigned the I-10 number on August 14, 1957, and the short piece west of I-5 was approved as I-110 on November 10, 1958. By then, most if not all of the San Bernardino Freeway had been completed, and I-10 was signed along the existing freeway along with US 70, US 99, and part of US 60. Those three routes were all removed in the 1964 renumbering, leaving only I-10.