The two soon become enmeshed in a plot by the Shogunate conceived by the ruthless Matsudaira Nobutsuna and spearheaded by his chief henchman Mamiya Rinzō (also based on an actual historical character) to topple the Satsuma clan and assume control of that fiefdom's great wealth, using Tōgō as an unwitting pawn. When Tōgō discovers that he has been tricked and used, he and Daigoro embark on the road of "meifumado" in a quest to kill the Shogun (which would force Matsudaira out into the open). However, Rinzō, who is not only a master of disguise but also Matsudaira's natural son, may have an even more devious plan of his own, including subverting the Shogun's own ninja and using opium to ensnare and enslave the Shogun himself. This series also introduces non-Japanese characters into the plotlines. Dark Horse began publishing the follow-up series, under the title "New Lone Wolf and Cub", in June 2014; as of December 2016, all eleven volumes have been released.