Champions of the Mexican Apertura 2015 season, Tigres qualified to the 2016–17 CONCACAF Champions League. The team won the first match of the group stage against Herediano on 4 August 2016, by 3–1 at the Estadio Eladio Rosabal Cordero. The second match was also a victory by 3–1, this time against Plaza Amador on 17 August at the Estadio Universitario. The third match, against Plaza Amador, Tigres fell by 0–1 on 28 September at the Estadio Maracaná. In the last match of the group stage, Tigres won by 3–0 against Herediano at the Estadio Universitario. In the knockout stage, Tigres beat Pumas UNAM by 1–1 in the home leg and by 3–0 in the away leg. In semifinals, Tigres defeated Vancouver Whitecaps by 2–0 in the home leg and 2–1 in the away leg. Tigres lost the finals against Pachuca FC by 1–1 in the first leg and 0–1 in the second leg.