North of NY 25A, NY 106 changes names to Oyster Bay Road, becoming a four-lane divided commercial arterial for one city block, becoming residential as it enters the East Norwich section of Oyster Bay. With this change, the divided highway becomes a two-lane local street, bending northeast near the James H. Vernon School. The route continues north past the Upper Brookville section, changing names to Pine Hollow Road. A short distance later, it enters the hamlet of Oyster Bay, bending northeast as a two-lane commercial/residential blend street. Crossing Berry Hill Road, NY 106 bends northward, changing names to South Street, becoming mainly commercial. After the crossing with West Main Street, NY 106 bends to the northeast a final time, passing east of the Long Island Rail Road's Oyster Bay Yard on the Oyster Bay Branch. A short distance after, NY 106 enters Commander Square and terminates at an intersection with Bay Avenue.