PA 36 begins in the Bedford County hamlet of Yellow Creek at PA 26 along the Tussey Mountain range. The distance in Bedford County is brief as the highway enters Blair County and proceeds northward as the Woodbury Pike, intersecting several 800-series state highways like PA 866, PA 868, and PA 869. A short distance between Roaring Spring and the hamlet of McKee, PA 36 overlaps the east–west running PA 164. North of McKee, PA 36 becomes Catfish Ridge Road, closely paralleling the Frankstown Branch Juniata River to the west, and the Interstate 99–U.S. Route 220 overlap to the east along the Brush Mountain range.