In 2004, Chavira was cast as Carlos Solis, the husband of Eva Longoria’s character, Gabrielle Solis, in the ABC comedy-drama series "Desperate Housewives". The series was a breakthrough hit for ABC receiving wide coverage. In 2005, Chavira listed on the "50 Most Beautiful" list in "People en Español", and the following year named one of "TV's Sexiest Men" by "TV Guide". Along with cast, he received two Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series in 2005 and 2006, and well as three ALMA Awards nominations for Outstanding Actor in a Comedy Series. The series ended in 2012 after eight seasons.