By far the most successful English privateer was Christopher Newport who was backed financially by Watts. Newport set out in 1590 to raid the Spanish West Indies and in the ensuing fight saw the defeat of an armed Spanish convoy but Newport lost his right arm in the process. Despite this Newport continued the venturesthe blockade of Western Cuba in 1591 was the most successful English privateering venture made during the war. Both Drake and Hawkins died of disease on the later 1595–96 expedition against Puerto Rico, Panama, and other targets in the Spanish Main, a severe setback in which the English suffered heavy losses in soldiers and ships despite a number of minor military victories.