The Indios started the season 2-0, before falling to the Bayamón Cowboys on March, 6 (90-83). After blowing an 11-point lead going into the fourth quarter with Guaynabo on March 9, 2012 for a 95–94 loss, Mayagüez won three straight to put their record at 5–2. Another loss to Bayamón on March 17, 2012 dropped them to 5–3. The Indios then went on an 8-game winning streak, the longest for any team that season to obtained the first position on the standing with a 13–3 mark. Their rivals and fellow neighbors the San Germán Athletics beat Mayagüez on April 7, 2012 87–79 stopping the Indios' 8-game winning streak.