Fletcher co-starred in such made-for-TV movies as " The Karen Carpenter Story" (1989) (as Karen and Richard Carpenter's mother, Agnes), "Nightmare on the 13th Floor" (1990), "The Haunting of Seacliff Inn" (1994), and "The Stepford Husbands" (1996). From 1993 to 1999, she held a recurring role in "" as the scheming Bajoran religious leader Kai Winn Adami. She also earned Emmy Award nominations for her guest roles on Tom Skerritt's CBS television series, "Picket Fences" (1996), and later on "Joan of Arcadia" (2004). In 2009, Fletcher appeared in the NBC series "Heroes" as the physician mother of character Emma Coolidge. In 2011, she appeared in the Showtime series "Shameless" as Grammy Gallagher, Frank Gallagher's foul-mouthed and hard-living mother who is serving a prison sentence for manslaughter related to a meth lab explosion.