Guo Xiu, whose courtesy name was Xiaoxian (), was quite well known in Liang Province before he joined Shu. After he was captured in battle by the Shu general Jiang Wei, he reluctantly surrendered and pledged allegiance to Shu. The Shu emperor Liu Shan appointed him as General of the Left (). Guo Xiu once attempted to assassinate Liu Shan under the pretext of congratulating the emperor. However, Liu Shan's bodyguards noticed something suspicious about his behaviour and stopped him before he could get close to the emperor. Frustrated at his failure to assassinate the Shu emperor, Guo Xiu switched his target to the regent Fei Yi instead and succeeded. In September or October 253, the Wei emperor Cao Fang issued an imperial decree to praise Guo Xiu for his "heroic service to Wei" and compare him to Nie Zheng and Jie Zhitui, as well as to confer posthumous honours on him and grant rewards to his family.