Although it has a comparatively low venom yield, its toxicity is considered to be the second highest of all rattlesnake venoms (next to the mojave), and the second highest of all snakes in the Western Hemisphere. It has a high neurotoxic fraction that is antigenically related to Mojave toxin (see "Crotalus scutulatus", venom A), and includes another component immunologically identical to crotamine, which is a myotoxin also found in tropical rattlesnakes (see "Crotalus durissus"). A low but significant protease activity is in the venom, although it does not seem to have any hemolytic activity.