Meanwhile, Slade's relationship with his estranged wife Adeline took a tragic turn, as Slade underwent a process to gain the ability of physical regeneration, allowing him to survive any wound so long as his brain is intact (but this power is limited, as Slade cannot regenerate his lost eye because that injury happened before he gained his healing factor). After gaining this power, Slade was forced to give his wife a blood transfusion to save her life, resulting in her gaining a similar healing factor which manifested itself as a form of immortality. This alteration of her DNA drove Adeline insane, shaming Deathstroke into going into a semi-retirement state.