In February 2016, Tsai joined the voice cast of Disney animated comedy-adventure film, "Zootopia". She voiced a European rabbit named Judy Hopps who is a newly appointed member of the Zootopia Police Department in the film's Taiwanese version. In May 2016, Tsai performed at a special event held by South Korean music program broadcast M Countdown in China. In September 2016, Tsai collaborated with Swedish DJ Alesso and released an English single, "I Wanna Know", which reached number twenty-five on the Hit FM Top 100 Singles of the Year. At the same time, she and Alesso closed International Music Summit's Asia-Pacific event with a discussion of what it takes to bridge the gap between East and West in electronic music. In October 2016, she and Alesso performed the single, "I Wanna Know", and a remix version of her song, "Play", together at the Storm Music Festival in Shanghai. In the same month, Tsai collaborated with Taiwanese producer Starr Chen and released a new single, "Ego-Holic", which reached number fifty-two on the Hit FM Top 100. In December 2016, Tsai's songs has over 100 million downloads over the past ten years through Migu Music, an online music store under China's biggest mobile network operator China Mobile, made her the highest record sales for a female artist in Asia. In May 2017, Tsai released a new single, "Give Love", for the 2017 Mother's Day and a related public interest campaign presented by the Taiwan television station Da Ai Television. In June 2017, Tsai collaborated with Dutch DJ Hardwell and released an English single, "We Are One", which reached number ninety-nine on the Hit FM Top 100. In November 2017, Tsai recorded the theme song, "On Happiness Road", for the 2018 Taiwanese animated film under the same title. In December 2017, she recorded the theme song, "Stand Up", for the 2018 Chinese film, "Monster Hunt 2". In January 2018, Tsai released her seventh live album, "Play World Tour". In June 2018, Tsai recorded the 10th anniversary theme song, "The Player", for the video game, "Dungeon & Fighter".