"Brothers and Sisters" was one of the last additions to the album. "It was a kind of track that took quite a different direction for most of its life", said Rowntree. "...And then right at the end we switched about and took it in a different direction, it wasn't quite so dark." "It sounded more like The Velvet Underground when we started", claimed Albarn. "It was too overtly about one thing. It was too druggy, in a way, which is a kind of weird thing, 'cause the song is all about drugs so I think we just pushed ourselves a bit more with it and gave it a lot more space – countered by the list and the list was kind of sort of inspired by the life of JFK and his need to have 28 drugs everyday of his Presidency just to keep him functioning."