Born in Florence, Vermigli entered a religious order and was appointed to influential posts as abbot and prior. He came in contact with leaders of the Italian "spirituali" reform movement, and read Protestant theologians such as Martin Bucer and Ulrich Zwingli. Through reading these works and studying the Bible and the Church Fathers, he came to accept Protestant beliefs about salvation and the Eucharist. To satisfy his conscience and avoid persecution by the Roman Inquisition, he fled Italy for Protestant northern Europe. He ultimately arrived in Strasbourg where he taught on the Old Testament of the Bible under Bucer. English reformer Thomas Cranmer invited him to take an influential post at Oxford University where he continued to teach on the Bible. He also defended his Eucharistic beliefs against Catholic proponents of transubstantiation in a public disputation. Vermigli was forced to leave England on the accession of the Catholic Queen Mary. As a Marian exile he returned to Strasbourg and his former teaching position. Vermigli's beliefs regarding the Eucharist and predestination clashed with those of leading Lutherans in Strasbourg, so he transferred to Reformed Zürich where he taught until his death in 1562.