One argument against dualism is with regard to causal interaction. If consciousness ("the mind") can exist independently of physical reality ("the brain"), one must explain how physical memories are created concerning consciousness. Dualism must therefore explain how consciousness affects physical reality. One of the main objections to dualistic interactionism is lack of explanation of how the material and immaterial are able to interact. Varieties of dualism according to which an immaterial mind causally affects the material body and vice versa have come under strenuous attack from different quarters, especially in the 20th century. Critics of dualism have often asked how something totally immaterial can affect something totally material—this is the basic problem of causal interaction.