"Because of You" debuted on the US "Billboard" Hot 100 at number 84 in March; it reached the top ten in May when it climbed from number 39 to number 5 in one week. The song has become his second-most successful song in the U.S., after his 2006 number-one hit "So Sick". By May the single had reached a peak at number 2 on the "Billboard" Hot 100 chart, behind only Maroon 5's "Makes Me Wonder". It also peaked at number 4 in the UK, becoming Ne-Yo's only lead single from an album in that country to not reach the top spot, until "Time of Our Lives" from "Non-Fiction".