On September 6, 2012, Brokaw was hospitalized after appearing on MSNBC's "Morning Joe". He later tweeted that he was "all well" and explained his illness as having accidentally taken half a dose of Ambien in the morning. He was diagnosed with multiple myeloma, a treatable but incurable blood cancer, in August 2013 at the Mayo Clinic. Brokaw and his physicians are "very encouraged with his progress". He has continued to work for NBC throughout his treatments. On December 21, 2014, Brokaw announced that his cancer is in full remission.