WIS 22 passes north through the eastern portion of Marquette County where it meets WIS 23 in Montello. There is a short cosigning with 23 in town heading east before 22 turns north again. The highway then joins WIS 21 briefly in Wautoma. Both routes cross WIS 73 in the downtown area and WIS 21 splits southeast following WIS 73 while WIS 22 continues north, passing through Wild Rose eight miles (13 km) north of Wautoma. WIS 22 passes through the southeast corner of Portage County for about one mile (1.6 km) as it turns eastward. The highway stairsteps northeast for about nine miles (14 km), passing around Rural and King as it proceeds toward Waupaca. WIS 22 merges onto US 10 east (also carrying WIS 49 south and WIS 54 east) for one and a half miles, forming a brief wrong-way concurrency with WIS 49. Along with WIS 54, WIS 22 turns off US 10 to the north and into the city via Churchill Street. The two highways then turn east onto Royalton Street southeast of the city center and follow the Little Wolf River's south branch northeast.