On February 17, 2010, Sanchez underwent surgery to repair the patella ligament in his left knee that he originally injured when he played for USC. The surgery was successful. Sanchez was expected to miss early workouts and return in time for training camp however Sanchez made a quick recovery and participated in team drills during Organized Team Activities (OTA). The Jets opened the 2010 season with a 5–1 record despite the passing game being subpar as Sanchez struggled to accurately throw the football. Sanchez recorded his first career 300-yard passing game in a win over the Detroit Lions on November 7, 2010. At 10–4, the Jets faced the Chicago Bears on December 26, 2010 with a chance to clinch a playoff berth. Though Sanchez injured his shoulder in a victory over Pittsburgh the previous week, he started the game completing 24 of his 37 passes for a touchdown and an interception. However, the Jets were unable to defend the Bears' offense and subsequently lost the game 38–34 after a comeback drive was halted when Sanchez was intercepted. Fortunately for them, due to a loss by the Jacksonville Jaguars that same day, the Jets clinched the playoff berth. Sanchez finished the season with 3,291 yards, 17 touchdowns, and 13 interceptions.