Taruffi drove a newly introduced 2-litre, 4-cylinder Ferrari, which placed third in the 360 kilometre race Grand Prix de Bari at Bari, Italy, in September 1951. He finished behind Juan Manuel Fangio and Froilán González with a time of 2 hours 58 minutes 40 3/5 seconds. Taruffi and Alberto Ascari participated in the Carrera Panamericana in the mountains of Mexico in November 1951. They placed first and third respectively over the course from Mexico City to León, Guanajuato, a leg. Taruffi led second-placed Troy Ruttman by more than four minutes. Taruffi trimmed 15 minutes on the Mexico City-Leon leg and another 21 minutes between Leon and Durango. In the process he climbed from 12th to third overall. Taruffi won the race on 25 November, with a time of 21:57:52, over mountains and plains of the southeastern tip of Mexico. He had an average speed of 87.6 mph (140.97 km/h).