Five years after he went to Naples, a letter from Venerable Fr. Giovanni Agostino Adorno of Genoa to another Caracciolo, Fabrizio, begging him to take part in founding a new religious institute, was delivered by mistake to the newly ordained priest, and he saw in this circumstance an assurance of the Divine Will towards him (1588). He assisted in drawing up rules for the new congregation, which was approved by Pope Sixtus V, July 1, 1588, and confirmed by Pope Gregory XIV on February 18, 1591, and reconfirmed by Pope Clement VIII on June 1, 1592.