Like the Nikon F4, the F-801 is broadly compatible with most Nikon AI and AF F-mount lenses, though some features are unavailable depending on the lens type. All features are available when used with AF-type lenses. Non-CPU (AI and AI-S) lenses are supported, but only Manual and Aperture-Priority exposure programs are available, using centre-weighted metering. Autofocus is not supported with AF-I and AF-S lenses, and Vibration Reduction (VR) is not available regardless of the lens. Newer G-type lenses are usable with the Program and Shutter-Priority exposure programs (though it is possible to use them in Manual or Aperture-Priority programs, but only at minimum aperture).