On June 28, Holliday was placed on the 10-day disabled list due to a viral infection. On July 5, it was revealed that Holliday tested positive for an Epstein-Barr virus, a symptom associated with mononucleosis. He hit a game-tying home run in the ninth inning versus Craig Kimbrel of the Boston Red Sox on July 15, which the Yankees eventually won in 16 innings, 4−1. On August 6, Holliday was again placed on the 10-day disabled list due to a lower back strain. For the 2017 season, he batted .231/.316/.432.