In 2001, Karam made her record-breaking release "Nedmaneh". It sold over 4 million copies worldwide, and is one of Karam's most acclaimed albums to date. It followed on from the style of music first presented by Karam in "Oyoun Qalbi", and further experimented with new styles and sounds. The song "Aaskah" ("Falling in love") was an enormous hit, hitting number one all over the Middle East, and was also quite popular abroad. It was a more playful and vibrant song than most of Karam's previous work, with a strong bass line, and a distinct oriental influence. It was quite different from any Arabic song at the time, and appealed to a wide range of audiences. The success of album "Nedmaneh" brought about a number of awards, including a coveted "Murex D'or" for "Best Arabic Artist" award, and three special awards from Karam's production company, Rotana: "Artist of the Year", "Album of the Year" and "Highest Selling Album".