US Route 22 crosses into Pennsylvania from West Virginia as the William Penn Highway. It becomes concurrent with U.S. Route 30 (The Lincoln Highway from Times Square) and then west of Pittsburgh also with I-376, as the Penn Lincoln Parkway. It continues as such through Pittsburgh and beyond the end of the US 30 concurrency, and when I-376 reaches its eastern end at the Pennsylvania Turnpike junction with Interstate 76, US 22 resumes as the William Penn Highway again (with Murrysville as a control city on signs) as it begins the long climb eastwards up the Allegheny Plateau towards the gaps of the Allegheny Front, where it crosses the eastern continental divide in Tunnelhill, Pennsylvania where it descends along the same valley (Blair Gap) once used by the historic Allegheny Portage Railroad.