"Strikers" features multiple gameplay modes, such as the "Domination Mode," in which the player faces an opponent of the player's choosing. They can also adjust match settings to limit or expand the match time or number of goals which are necessary for victory. The player can also play through "Striker Challenges", where they select a session with certain obstructions, such as missing characters or a susceptible goalkeeper. If they are successful in passing, they are given further adjustments called "cheats", that can render shooting easier and turn off physical elements of the fields in the game. Training sessions appear in the form of "Strikers 101," where the player can practice individual aspects such as shooting and tackling. "Road to the Striker Cup" allows the player to compete in matches against the computer to gain rewards. The player can also partake in online matches with others around the world.