Elfriede died in October 1970, and Segrè married Rosa Mines in February 1972. That year he reached the University of California's compulsory retirement age. He continued teaching the history of physics. In 1974 he returned to the University of Rome as a professor, but served only a year before reaching the mandatory retirement age. Segrè died from a heart attack at the age of 84 while out walking near his home in Lafayette. Active as a photographer, Segrè took many photos documenting events and people in the history of modern science. After his death Rosa donated many of his photographs to the American Institute of Physics, which named its photographic archive of physics history in his honor. The collection was bolstered by a subsequent bequest from Rosa after her death from an accident in Tivoli in 1997.