A second, less widespread outbreak occurred in 1507, followed by a third and much more severe epidemic in 1517, a few cases of which may have also spread to Calais. In the 1517 epidemic, the disease showed a particular affinity for Englishmen; the ambassador from Venice at the time commented on the peculiarly low number of cases in foreign visitors. A similar effect was noted in the subsequent epidemic in 1528 when Calais (an English territory bordering France) experienced an outbreak of sweating sickness which did not spread into France. It was frequently fatal; half the population perished in some areas. It reached epidemic proportions in 1528 during its fourth outbreak. It broke out in London at the end of May and speedily spread over the whole of England, save the far north. It did not spread to Scotland, though it did reach Ireland where Lord Chancellor Hugh Inge was the most prominent victim. The mortality rate was very high in London; Henry VIII broke up the court and left London, frequently changing his residence. In 1529 Thomas Cromwell lost his wife and two daughters to the disease.