During Sinclair's senior year at Portland, she set an all-time Division I goal-scoring record with 39. She capped off her collegiate career with two goals in a 4–0 rout of UCLA in the national title game. This performance also gave her a career total of 25 goals in NCAA tournament play, also a record. She was named WCC Player of the Year becoming the second player in conference history to be honoured three times. Sinclair was also named Academic All-American of the Year by "ESPN The Magazine" after graduating with a 3.75 grade point average in life sciences. She was awarded the M.A.C. Hermann Trophy, becoming the fourth player and third woman to win it in back-to-back years. As a result of her record-setting season, Sinclair went on to win the Honda Sports Award as the nation's top soccer player, as well as the Honda-Broderick Cup, as the college woman athlete of the year. She became the third soccer player to win the award, joining Mia Hamm and Cindy Daws. Sinclair finished her collegiate career with 110 goals and 32 assists in 94 games.