Nash hosted the Style Network show "Clean House" from 2003 to 2010, for which she won an Emmy Award in 2010. As an actress, she played the role of Deputy Raineesha Williams in the Comedy Central comedy series "Reno 911!" (2003–2009) The series was relaunched on Quibi In April 2020. Nash received two nominations for Primetime Emmy Awards for Outstanding Supporting Actress in a Comedy Series and a Critics' Choice Television Award for Best Supporting Actress in a Comedy Series nominations for her performance as nurse Denise "DiDi" Ortley in the HBO comedy "Getting On" (2013–2015). She also starred as Lolli Ballantine on the TV Land sitcom "The Soul Man" (2012–2016), and played Denise Hemphill in the Fox horror-comedy anthology series, "Scream Queens" (2015–2016). In 2017, she began starring as Desna Simms, a leading character, in the TNT crime comedy-drama "Claws".