Emanuel is the son of Benjamin M. Emanuel and Marsha (Smulevitz) Emanuel. His father, Benjamin M. Emanuel, is a Jerusalem-born pediatrician who was once a member of the Irgun, a Jewish paramilitary organization that operated in Mandate Palestine. He provided free care to poor immigrants and led efforts to get rid of lead paint due to its negative consequences for children and as of 2010 lived in a suburb of Chicago. Emanuel’s mother, Marsha, a nurse and psychiatric social worker who was raised in the North Lawndale community on Chicago's West Side, was active in civil rights, including the Congress of Racial Equality (CORE). She attended marches and demonstrations with her children. In a 2009 interview Emanuel recalled that in his childhood "worrying about ethical questions was very much part and parcel of our daily routine."