As a companion to the "43 Folders" blog, Mann launched the sporadically broadcast "43 Folders" podcast in 2005. In 2007, Mann launched "You Look Nice Today", an award-winning comedy podcast that bills itself as "A Journal of Emotional Hygiene," an effort he created with Adam Lisagor and Scott Simpson. The show's run ended in 2015, but a spiritual successor, called "California King", was created in its wake in 2020 with the same team. Mann has also produced "QPR: Quotidian Public Radio", an audio podcast launched in January 2009, which was billed as "audio comfort food for annoyed liberals in fleece." Mann was one of the hosts on the "MacBreak" video podcast, and a core host on the "MacBreak Weekly" audio podcast. Since 2008, he has scaled back his appearances on the series.