In 1822 he went to a school at Southwell, then to one at Risley, and in 1825 to Winchester as a commoner. In Lowe's fragment of autobiography he shows an unpleasing picture of the under-feeding and other conditions of the school life of the time. The languages of Latin and Greek were the main subjects of study and Lowe records that both were easy for him. Lowe then attended University College, Oxford, and enjoyed the change; there as a pupil of Benjamin Jowett he gained a first class degree in Literae Humaniores and a second class in mathematics, besides taking a leading part in the Union debates. In 1835 he won a fellowship at Magdalen, but vacated it on marrying, on 26 March 1836, Georgiana Orred (d. 1884). Lowe was for a few years a successful tutor at Oxford, but in 1838 was disappointed at not being elected to the professorship of Greek at the University of Glasgow.