Latham worked regularly in television before being cast as Lip Gallagher in "Shameless", the second eldest of the Gallagher children. Lip is an intelligent and outspoken youth who is trying to escape from the Chatsworth estate in Stretford. He was 24 when he left the show. He took on other work between series, until he was written out of the show in 2008 to allow him to concentrate on other projects. He later returned to the role for the series finale in early 2013.