Having been tipped as the 2008 250cc champion, he finished 6th in the season opener in Qatar. At Jerez he looked set to win before his engine gave out on the final lap causing Marco Simoncelli to hit his bike and both riders to crash out, subsequently handing Mika Kallio the win. Bautista finally took his first win of the season at Estoril before he crashed out of the lead in China and Italy, while only finishing 14th in Le Mans.In Bautista's home race at the Catalunya circuit he dominated the qualifying sessions, took pole position and led the race from the start, but an error while switching gears in the last lap gave Marco Simoncelli the chance to pass him and left him unable to fight back before the finish line. The British round at Donington marked his fourth pole of the season. In another fight with Simoncelli, Bautista missed the top spot again after an overly optimistic passing manoeuver by Simoncelli in the penultimate lap, which caused both riders to go wide and allowed Mika Kallio to pass them and snatch the win again. A second win came at Assen, despite a bad start from pole position leaving him 8th at the end of lap 1. He added two more wins at San Marino and Malaysia and his string of ten podium finishes after the abysmal start to the year eventually saw him end the season in second place behind Simoncelli.