The character had a one-night stand with George O'Malley, in the second season. Series writer Stacy McKee, said of the sexual encounter: "There's no turning back. There's nothing George and Meredith can do. The damage is done – things will never be the same. They've just changed something important in their lives FOREVER and...they are freaking out." Grey's character development has also been known as an influence on the creation of her half-sister, Lexie Grey. Particularly, it has been made clear that they both share the same motives. McKee offered her thoughts: "Meredith and Lexie both want to succeed. They want to be strong. They want to feel normal. They want, so much, to be whole. But it's a struggle – a genuine struggle for them. Being hardcore doesn't come naturally. Sometimes, they have to fake it." Grey's personality has been compared with that of Alex Karev's. Rhimes offered the insight: