As a young boy during the pre-Meiji period in a fictional version of Japan, Enishi witnessed the (accidental) killing of his older sister, Yukishiro Tomoe, by her then-husband, Himura Kenshin. Filled with grief and anger, he swore to bring to the man who killed his only sister. Ten years later, during his introduction in the series, a now-adult Enishi encounters Kenshin once again, ready to complete the "jinchū". Enishi also forms "The Six Comrades", a group of six men (himself included), to assist him in his revenge against Kenshin.