Along I-295, the route is a six-lane freeway, coming to an exit for CR 684. Continuing east, the freeway crosses into Greenwich Township and has an interchange with CR 607. After passing near Greenwich Lake, there are exits for CR 653 and CR 673 within a short distance of each other. I-295/US 130 reaches an interchange with CR 680 on the border of Greenwich Township and East Greenwich Township. The road runs through a portion of East Greenwich Township before crossing back into Greenwich Township and coming to an interchange with CR 678 and CR 667 on the border of Greenwich Township and Paulsboro. Past this point, the freeway runs through marshy areas of Mantua Creek and continues into West Deptford Township. Here, there is an exit for CR 656. Passing near more industrial areas, I-295/US 130 has an interchange with the Mid-Atlantic Parkway, which provides access to Route 44 as well as to CR 643 and CR 660. Continuing northeast, the freeway passes over Conrail Shared Assets Operations' Penns Grove Secondary and reaches an interchange with Route 44 and CR 640. At this point, Route 44 begins to parallel I-295/US 130 on its northwest side as the two roads cross the Woodbury Creek. Route 44 ends at a cul-de-sac that has a ramp from the southbound direction of I-295/US 130 prior to another interchange that provides access to CR 644. The freeway passes near some homes before US 130 splits from I-295.