The International Society of Electrochemistry (ISE) was founded in 1949, and some years later the first sophisticated electrophoretic apparatus was developed in 1937 by Arne Tiselius, who was awarded the 1948 Nobel prize for his work in protein electrophoresis. He developed the "moving boundary," which later would become known as "zone electrophoresis", and used it to separate serum proteins in solution. Electrophoresis became widely developed in the 1940s and 1950s when the technique was applied to molecules ranging from the largest proteins to amino acids and even inorganic ions.