The show opened with the announcer's introduction: "A gay, new comedy about the life and loves of a secretary in Manhattan. It's time to "Meet Millie"." Millie lived in a Jackson Heights apartment with her mother (Florence Halop), who is continually on the lookout for a possible husband for Millie. Millie's boyfriend, J.R. "Johnnie" Boone, Jr. (Ross Ford), is the son of her boss (Earle Ross, Roland Winters). Aspiring poet-composer Alfred Prinzmetal (Marvin Kaplan) drops in for friendly visits. Isabel Randolph portrayed Mrs. Boone. Other cast regulars were Virginia Vincent, Harry Cheshire and Ray Montgomery.