When European settlers invaded Hispaniola, this eastern section belonged to the Caíçimu-Higüey kingdom of Taíno Indians. Leaders included Caciques Cotubanamá and Cayacoa, the female Caciqua Higuanamá and other leaders, male and female. This area became the last to be conquered by the Spanish. Juan de Esquivel led the conquest in 1503, a year after the brutal Nicolás de Ovando was appointed the new colony's governor. He assigned Esquivél to subjugate the area, justifying the assignment as payback for a Taino attack (led by Cotubanamá) on 8 Spanish sailors, which was in turn revenge for Spaniards who slaughtered the Cacique of nearby Saona for sport, setting a battle Mastiff to attack him as he was loading traded cassava bread on a barge.