Scherzer met his future wife, Erica May, at the University of Missouri, where they both were pitchers. May pitched for the Mizzou softball team before a heart condition forced her to stop playing. After more than eight years of dating, the couple married in November 2013, and have two daughters. They welcomed Brooklyn, their first daughter, on November 29, 2017. On July 4, 2019, Kacey Hart Scherzer was born. The family resides in McLean, a suburb of Washington, D.C., in Northern Virginia, but listed the home for sale in 2020. That same year, he purchased a home in Jupiter, Florida. The family own four rescue dogs and two cats.