In his second major league season, Holliday became the cleanup hitter behind franchise icon Todd Helton in the middle of the 2005 season. After 119 at bats into the season, Holliday hit his first home run against Noah Lowry of the San Francisco Giants on May 17. He hit his second career multi-homer game and first with three extra base hits against the Cardinals on June 2. He was placed on the disabled list (DL) with a right fractured pinky and returned to play on July 18. He earned his first NL Player of the Week award for July 25 to 31, after batting .444 with three home runs, eight RBI, an .852 slugging percentage and a league-leading 12 hits and 23 total bases.