After a slow start to the historic campaign, Loxton struck form midway through the English summer and forced his way into the team for the last three Tests. He played a prominent role in the Fourth Test, scoring an aggressive and counterattacking 93 that helped Australia pry the initiative from England; the tourists eventually won the match. In 1949–50, Loxton cemented his position in the national team, playing in all five Tests in South Africa and scoring his only century at international level. He remained a regular member of the Test team until a form slump during the 1950–51 home season; he was dropped after three Tests against England and never played for Australia again. Loxton continued to play for Victoria in domestic competition until retiring at the end of the 1957–58 season.