In 1901, he moved to the University of Odessa. Of great importance to Misirkov was the founding of the Macedonian Scientific and Literary Society in Petersburg. Its creation was influenced by the Macedonian Club founded in Belgrade. After the Club was closed, its chief founders left for the Russian capital, where they organized the new Macedonian Society. This foundation in 1902 became the most important Macedonian institution abroad. In the same year this Society sent a special Memorandum to the Great Powers, in which the Macedonian Question was examined from the national point of view. It was proposed also Macedonian literary language to be codified. The question was also examined of establishing a Macedonian Church under the Ohrid Archbishopric. The aim of this Memorandum was that the Macedonians should be recognized as a separate nation and that Macedonia should be granted full autonomy within the Ottoman Empire. During this time he also examined the medieval period in Macedonia and his works contributed to the understanding of the 14th-century local ruler Krali Marko.