After Crake's wonder drug BlyssPluss is widely distributed, a global pandemic, deliberately caused by it, breaks out and begins wiping out the human race and causing mass chaos outside of the protected Rejoov compound. Realizing that this was planned by Crake all along, and sensing that something dangerous is happening regarding Crake and Oryx, Jimmy grabs a gun to confront Crake, who is returning with Oryx from outside the compound and needs Jimmy to let them in. Crake presents himself to Jimmy with his arm around an unconscious Oryx, saying that he and Jimmy are immune to the virus. Jimmy lets them in, whereupon Crake slits Oryx's throat with a knife. Jimmy then immediately shoots Crake dead.