In science, however, the meaning of theory is more rigorous. A scientific theory is "a well-substantiated explanation of some aspect of the natural world that can incorporate facts, laws, inferences, and tested hypotheses." Theories are formed from hypotheses that have been subjected repeatedly to tests of evidence which attempt to disprove or falsify them. In the case of evolution through natural selection, Darwin conceived the hypothesis around 1839, and made a first draft of the concept three years later in 1842. He discussed this widely with many of his intellectual companions, and conducted further research in the background to his other writings and work. After years of development, he finally published his evidence and theory in "On the Origin of Species" in 1859.