Methodios was enthroned as the Bishop of Boston on April 8, 1984, following his election to that post by the Holy Synod of the Ecumenical Patriarchate in Phanar, Constantinople, Turkey. In July 1989, Bishop Methodios assumed the presidency of Hellenic College and Holy Cross Greek Orthodox School of Theology in Brookline, Massachusetts, a position he held until 1995. In November 1997, the Holy Synod of the Ecumenical Patriarchate elevated Bishop Methodios to the office of Metropolitan along with the other bishops of the Archdiocese of America. His see, however, remained a diocese until December 2002.