According to the sheet music published at Musicnotes.com by Alfred Music Publishing, "Me, Myself and I" is an R&B song performed in a moderately slow manner. It is written in the key of D♭ major; the tempo is set to eighty-four beats per minute, in common time. The chord follows the E♭m9-Fm7-G♭Maj7 keys, appearing every other bar, and the song has a string arrangement. According to Ryan Schreiber of Pitchfork Media, the song's instrumentation consists of a blending of funk keyboards, a slippery bass and minimal, programmed R&B percussion instruments.