While serving at Bird's Point and the surrounding area, the 2nd Iowa lived in poor conditions, which caused much illness. An estimated 400 of 1000 men were able to serve. Because of the poor state of health, the 2nd Iowa was ordered to the Benton Barracks in St. Louis, Missouri, in order to recuperate and recruit in order to replace the men who had died from disease. The 2nd Iowa arrived in St. Louis on October 29, and by December 26 the regiment's sick list numbered about 200.