There is very little information available for bite symptoms. Human bites by the tiger rattlesnake are infrequent, and literature available on bites by this snake is scarce. The several recorded human envenomations by tiger rattlesnakes produced little local pain, swelling, or other reaction following the bite, and despite the toxicity of its venom no significant systemic symptoms. The comparatively low venom yield (6.4–11 mg dried venom) and short to fangs of the tiger rattlesnake possibly prevent severe envenoming in adult humans. However, the clinical picture could be much more serious if the person bitten was a child or a slight build individual. The early therapeutic use of antivenom is important if significant envenomation is suspected. Despite the low venom yield, a bite by this rattlesnake should be considered a life-threatening medical emergency. Untreated mortality rate is unknown but this snake has a very high venom toxicity and its bites are capable of producing major envenomation.