Loxton played in all five Tests, and in the First Test at the Wanderers in Johannesburg, he scored his first Test century. He compiled 101 in 150 minutes, helping Australia to a total of 413 after both opening batsmen were out without scoring. Hassett's men went on to win the match by an innings. The Second Test was an eight-wicket victory for the Australians, this time dominated by Harvey's 178, with whom Loxton shared a 140-run stand for the fifth wicket, contributing 35 himself. He also took a wicket. The Third Test at Kingsmead in Durban was dramatic; batting first, South Africa made 311 and Hugh Tayfield then took 7/23 as Australia collapsed to 75 all out after the rain and sun had baked the playing surface into a sticky wicket. During the first innings, Hassett changed his batting order so that his better batsmen were low down in the order so that they could bat in better conditions as the pitch stabilised. Loxton batted at No. 10 and Harvey at No. 9, but the Australians collapsed before the pitch had changed measurably. Not enforcing the follow-on, the South Africans batted again and were themselves bowled out for 99, losing their last seven wickets for 14 runs. This left Australia to chase 336 runs for victory, highly unlikely as the last 28 wickets had fallen for only 245. The tourists were still more than 200 runs in arrears when Loxton came in to join Harvey. On Loxton's first ball, a delivery from Tayfield narrowly missed his edge. He survived to lunch after being caught from a no-ball on the long on boundary from a lofted drive. With an unbeaten 151, Harvey took Australia to an improbable five-wicket victory, supported by his fellow Victorian, who scored 54 in a century partnership.