Guccione was a painter whose art premiered at Nassau County Museum of Art as well as the Butler Institute of American Art. His art continues to hang in the Borghi Fine Art Gallery, is featured in the POBA - Where the Arts Live online collection, and is a part of the Filthy Gorgeous Media art collection. Bob Guccione was a world-renowned collector of fine art. Highlights of the Guccione collection included a portrait by Amedeo Modigliani and a Pablo Picasso portrait of the artist's son, Paulo. He owned paintings by Sandro Botticelli, Albrecht Dürer, El Greco, Marc Chagall, Salvador Dalí, Giorgio de Chirico, Edgar Degas, Fernand Léger, Gilbert Stone, Henri Matisse, Jules Pascin, Camille Pissarro, Pierre-Auguste Renoir, Georges Henri Rouault, Chaïm Soutine, and Vincent van Gogh.