Dragon spacecraft can return of cargo to Earth, which can be all unpressurized disposal mass, or up to of pressurized cargo, from the ISS, and is the only current spacecraft capable of returning to Earth with a significant amount of cargo. Other than the Russian Soyuz crew capsule, Dragon is the only currently operating spacecraft designed to survive re-entry. Because Dragon allows for the return of critical materials to researchers in as little as 48 hours from splashdown, it opens the possibility of new experiments on ISS that can produce materials for later analysis on ground using more sophisticated instrumentation. For example, CRS-12 returned mice that have spent time in orbit which will help give insight into how microgravity impacts blood vessels in both the brain and eyes, and in determining how arthritis develops.