US 206 crosses the Crosswicks Creek and enters Hamilton Township, Mercer County. Immediately after the Crosswicks Creek, there is an interchange with I-195. Past I-195, the route reaches the White Horse Circle, where it intersects CR 524 and CR 533. At this point, US 206 turns west-northwest to run along four-lane divided locally maintained Broad Street. Passing through White Horse, the road briefly becomes five lanes with a center left-turn lane before becoming a four-lane divided highway again as it crosses over I-295 without an interchange. Running into more urban areas of development, the route enters Trenton at the crossing of CR 650 After entering Trenton, US 206 narrows into a two-lane undivided street. As the road heads toward downtown Trenton, it crosses NJ Transit’s River Line immediately before interchanging with Route 129. From here, the road turns more to the northwest with four lanes and passes by the CURE Insurance Arena before crossing over Amtrak’s Northeast Corridor and the US 1 freeway simultaneously. US 206 enters the commercial downtown area, narrowing back to two lanes before reaching Warren Street, where US 206 splits into a one-way pair following Broad Street northbound and Warren Street southbound.