In the fifth and last season of the show (titled "Tales of the Teenage Mutant Ninja Turtles"), April continues to be there for the Turtles and help them adjust to moving on with their lives without Splinter. Unfortunately, her innate, extraordinarily strong mental powers prove to be ineffective against the mighty demodragon, Kavaxas, as he is not of the earthly plane. She worked together with Karai in finding Bebop heading to Don Visiozo's restaurant, where a vial containing the heart of the Super Shredder was being held. Aware of the Seal of the Ancients power over Kavaxas, she attempted to use it by combing its dark magic with her own growing sensory abilities, but was unsuccessful. Intrigued by her unique human/Kraang nature, Kavaxas desired to sallow her very essence in order to obtain her increasingly powerful mental abilities for himself, despite that they are ineffective on him.