"Crash Twinsanity" received mixed reviews from critics upon release. The open-world setting was welcomed as an improvement over the "claustrophobic" level design of previous games, and the various gameplay styles were commended as clever and well-implemented; James B. Pringle of "IGN" compared the 'ingenious' Doc Amok levels to "Lemmings", and Louis Bedigian of "GameZone" considered the RollerBrawl sequence to be the game's best. However, the platforming sections were considered formulaic and tired. The gameplay aspect of controlling Crash and Cortex in tandem drew comparisons to "" and "Whiplash", while the RollerBrawl segment was widely compared to "Super Monkey Ball". The character Nina Cortex was positively received by critics, some of whom compared her extending robotic arms to "Bionic Commando". The game's camera was widely criticized as dodgy and uncooperative, and the controls were deemed sluggish. Kristan Reed of "Eurogamer" and GR Chimp of "GameRevolution" respectively derided the checkpoint/autosave system as faulty and spaced too far apart.