He was educated at a secular primary school, after which he went to the three-year HBS high school. From 1897 to 1899 he went to the "Openbare Handelsschool" (a college level business school). After this he started work as an office clerk in Hengelo, but quickly returned to Amsterdam, where he held a succession of similar jobs. In 1905 Nescio married Aagje Tiket, with whom he would raise four daughters. Until his death in a Hilversum sanatorium in 1961, Nescio would remain in Amsterdam.