April appears in the reboot "Teenage Mutant Ninja Turtles" with Megan Fox playing the role. During the film, it is revealed that not only was April's father involved in the creation of the turtles as his experiments created the mutagen that turned them into what they are now, but that the young April was responsible for the Turtles and Splinter escaping the destruction of the lab where they were created when she released them into the sewers after the lab was destroyed by her father to prevent Shredder and Eric Sacks getting access to the mutagen.