In 2011, del Castillo earned worldwide recognition for playing the lead role in the Telemundo series "La Reina del Sur". In 2017, she went to star in the Netflix political drama series "Ingobernable" playing First Lady of Mexico Emilia Urquiza. del Castillo made her Hollywood debut playing a female leading role in the 2007 drama film "Under the Same Moon" and later appeared in supporting roles in films "No Good Deed" (2014), "The 33" (2015), and "El Chicano" (2019) and "Bad Boys for Life" (2020).