In 2018, the #4 Wolverines visited the #10 Buckeyes in a game with both Big Ten Championship and College Football Playoff implications. At a pre-game press conference, Michigan's running back Karan Higdon guaranteed a victory over Ohio State. Michigan entered the game with the best statistical defense in the country, but Ohio State gained more than 560 yards - including 6 touchdown passes - en route to a dominant 62–39 victory. Ohio State's 62 points set a record for points against Michigan during regulation, and the victory improved Meyer's Ohio State teams' record against Michigan to 7–0. Harbaugh fell to 0–4 against Ohio State, making him the first Michigan coach to lose his first four starts against the Buckeyes. The 2018 meeting would be Meyer's last against Michigan, as he announced his retirement at the end of the season.