The next two objections, are metaphysical objections which argue that even if the semantic objections fail, human genetic clustering results do not support the biological reality of race. The 'very important objection' stipulates that races in the US definition fail to be important to biology, in the sense that continental populations do not form biological subspecies. The 'objectively real objection' states that "US racial groups are not biologically real because they are not objectively real in the sense of existing independently of human interest, belief, or some other mental state of humans." Racial naturalists, such as Quayshawn Spencer, have responded to each of these objections with counter-arguments. There are also methodological critics who reject racial naturalism because of concerns relating to the experimental design, execution, or interpretation of the relevant population-genetic research.