Fabiański started the 2010–11 season as Arsenal's second-choice goalkeeper. On 21 September 2010, he made his first start of the season in a League Cup match against neighbours Tottenham Hotspur at White Hart Lane, which Arsenal won 4–1 after extra time. Fabiański almost cost the match for Arsenal as he failed to stop Robbie Keane's long-range effort, despite getting a hand to the shot. After the match, he revealed he was disappointed. He had a solid match in his second match of the season replacing the injured Manuel Almunia one week later in a UEFA Champions League 3–1 away win against Partizan. He saved Cléo's second penalty of the match in the second half to deny Partizan a lifeline. He later turned Ivica Iliev's effort around the post from point-blank range just before the final whistle. Arsène Wenger later commented that Fabiański had a "faultless" match and they finally saw the player who they usually see in training. He kept his first clean sheet in a win over Manchester City, where he made many saves in a match that ended 3–0. He was later named man of the match on an Arsenal.com poll after a brilliant display to keep Arsenal in the match. After the City match, Wenger admitted he could well become the club's number one goalkeeper after impressive displays in the matches since the Partizan match.