The fight took place on 8 September 2018, Khan won the fight by UD, with scores of 119–108, 119–109 and 118–110. Khan knocked Vargas twice in the fight in dropping him in round two and three. Vargas dropped Khan once in round three. Khan fought well in round five in landing a lot of fast combinations to the head of Vargas, who suffered a nose injury. Vargas took the punishment and showed a lot of heart as he kept coming forward. Midway through the fight, Khan began to slow down and showed fatigue. He began to pick his combinations rather than just throw a flurry. Vargas focused mostly on the body attack for the fight. He managed to have Khan in trouble as he pinned him against the ropes, most notably in rounds six and ten. After the fight, Khan said, "I really wanted to go the distance. It's been three years since I went twelve rounds. There were a couple of times when I could have stopped him and I kind of stepped off him." Khan called for a fight against former sparring partner Manny Pacquiao and Eddie Hearn said it was 'now or never' for a Kell Brook fight. According to CompuBox stats, Khan landed 199 punches of 581 thrown (35%) and Vargas was credited with landing 142 of his 535 thrown (27%). Vargas landed 100 shots to Khan's body, 91 being power punches. Hearn announced that the fight set a viewership record, for the biggest live audience on UK subscription television in boxing history.