The gallery was founded in 1961 by Jeremy Rees, and was originally located in Clifton. In the 1970s it moved to Queen Square, before moving to its present location, Bush House on Bristol's waterfront, in 1975. The name of the gallery is taken from Jan van Eyck's 15th-century painting "The Arnolfini Portrait". Arnolfini has since been refurbished and redeveloped in 1989 and 2005. Artists whose work has been exhibited include Bridget Riley, Rachel Whiteread, Richard Long and Jack Yeats. Performers have included Goat Island Performance Group, the Philip Glass Ensemble, and Shobana Jeyasingh Dance Company. The gallery reached a new audience in April 2010, when it was chosen to host one of the three 2010 general election debates.