In January 2012, only eleven months after returning from a successful deployment to Afghanistan, VMM-365 returned to Camp Bastion to conduct combat operations in support of Operation Enduring Freedom. During the month of April, the squadron conducted 35 Named Operations and increased that number to 39 in May and 42 in June. VMM-365 flew in support of 193 Named Operations over the course of the seven-month deployment. By comparison, the squadron conducted just 10 Named Operations during OEF 10.2. In addition to successfully supporting an average of one Named Operation per day, the squadron moved 36,047 passengers and 769,102 pounds of cargo across the battle space while conducting General Support missions.