The station is the terminus of the state's regional railway network operated by V/Line, "The Overland" rail service to Adelaide, and NSW TrainLink XPT services to Sydney. It is also served by suburban rail services operated by Metro Trains, being one of five stations on the City Loop, a mostly underground railway that encircles the Central Business District. It is the second busiest railway station in Melbourne's metropolitan network, with 18.614 million passenger movements recorded in 2017/18. This figure excludes V/Line passengers who use the station.