In 1938, Benito Mussolini's fascist government passed anti-Semitic laws barring Jews from university positions. As a Jew, Segrè was now rendered an indefinite émigré. At the Berkeley Radiation Lab, Lawrence offered him a job as a research assistant. While at Berkeley, Segrè helped discover the element astatine and the isotope plutonium-239, which was later used to make the Fat Man nuclear bomb dropped on Nagasaki. From 1943 to 1946 he worked at the Los Alamos National Laboratory as a group leader for the Manhattan Project. He found in April 1944 that Thin Man, the proposed plutonium gun-type nuclear weapon, would not work because of the presence of plutonium-240 impurities. In 1944, he became a naturalized citizen of the United States. On his return to Berkeley in 1946, he became a professor of physics and of history of science, serving until 1972. Segrè and Owen Chamberlain were co-heads of a research group at the Lawrence Radiation Laboratory that discovered the antiproton, for which the two shared the 1959 Nobel Prize in Physics.