Melina made her official debut in WWE as a heel, resuming her role as the manager of MNM, on the April 14, 2005 episode of "SmackDown!". The team interrupted the first ever "Carlito's Cabana" interview segment, where one half of the WWE Tag Team Champions, Rey Mysterio, was a guest. Melina insulted Mysterio and had Mercury and Nitro attack him, leading to MNM's in-ring debut the next week on "SmackDown!" in a title match. The team won the match against Mysterio and Eddie Guerrero, starting their first WWE Tag Team Title reign.