Debiprasad Chattopadhyaya obtained his academic training in philosophy in Calcutta, West Bengal under eminent philosophers like Sarvapalli Radhakrishnan and S. N. Dasgupta. After standing first in philosophy at University of Calcutta both in B.A. (1939) and M.A. (1942), he did his post-graduate research work under Prof S. N. Dasgupta. He taught philosophy at the City College of Calcutta for three decades. Subsequently, he was appointed a UGC Visiting Professor at the universities of Andhra Pradesh, Calcutta and Poona. He remained associated with the activities of the Indian Council of Historical Research (ICHR), Indian Council of Philosophical Research (ICPHR) and the National Institute of Science, Technology and Development Studies (NISTADS) of the Council of Scientific & Industrial Research (CSIR) under various capacities. His second wife was the renowned educationist and Tibetologist, Dr. Alaka Majumder Chattopadhyaya (1926–1998).