The network was founded by Geraldine Laybourne, and carried a format focused on lifestyle and entertainment programming oriented towards women, similar to competing channels such as Lifetime. NBCUniversal acquired the network in 2007; under NBCU ownership, the network increasingly produced reality shows aimed at the demographic, and was relaunched in 2014 to target a "modern", younger female audience. After the network experienced ratings successes with a programming block dedicated to such programming, Oxygen was relaunched in mid-2017 to focus primarily on true-crime programs.