First, it is not clear "where" the interaction would take place. For example, burning one's finger causes pain. Apparently there is some chain of events, leading from the burning of skin, to the stimulation of nerve endings, to something happening in the peripheral nerves of one's body that lead to one's brain, to something happening in a particular part of one's brain, and finally resulting in the sensation of pain. But pain is not supposed to be spatially locatable. It might be responded that the pain "takes place in the brain." But evidently, the pain is in the finger. This may not be a devastating criticism.