During the summer of 1959, "Charles R. Ware" took part in the historic Operation Inland Seas, the first passage of a naval force through the Saint Lawrence Seaway into the Great Lakes. She took part in the Naval Review in Lake Saint Louis on 26 June, which was taken by Queen Elizabeth II and President Dwight D. Eisenhower, and sailed on to call at a number of United States and Canadian ports. During her 1960 Mediterranean tour, she carried German naval observers during an exercise in the Ionian Sea.