WIS 22 joins WIS 32 south in Gillett and the two routes run concurrent for three miles (5 km) east to where WIS 32 turns south off while WIS 22 continues east, passing through Oconto Falls. In 2014, an 8.1-mile stretch of STH 22 between Gillett and Onconto Falls was honored with the Sheldon G. Hayes Award for being the smoothest asphalt pavement in the country. The highway crosses US 141 in Stiles Junction eight miles (13 km) west of its eastern terminus at US 41 in Oconto. The terminus is adjacent to Copper Culture State Park.