When the first state highways were signed in the field in 1919, M-53 was one of them, running from Detroit to Elkton. In the 1920s, the highway was extended northward to connect with Port Austin. Later improvements through 1940 realigned a section of the roadway near Imlay City and completed paving. With planning and construction during the 1950s and 1960s, the state converted portions of the road north of Detroit to have divided highway and freeway segments. The freeway bypass of Romeo was started in the 1990s and finished to its current state in 2003.