At the beginning of the 16th century, Eastern Armenia fell under the Safavid Persian rule. The territory of modern-day Vayk became part of the "Erivan Beglarbegi" and later the Erivan Khanate. The period between the 16th and 17th centuries is considered to be the darkest period in the history of Vayots Dzor. The region was turned into a frequent battlefield between the invading troops of the Turkic and Iranian tribes. As a result, many significant monuments and prosperous villages were destroyed and the population was displaced. In 1747, the region became part of the newly-formed Nakhichevan Khanate.