In 1878, he entered into politics as a member of the Liberal Party and, after relinquishing a tied vote to his opponent, eventually won a place in the British House of Commons in 1880. In 1894 Grey inherited the Earldom Grey from his uncle, the third Earl, and thereafter took his place in the House of Lords, while simultaneously undertaking business ventures around the British Empire as Director of the British South Africa Company from 1898, he experienced a steep learning curve during high tension with the Boers. As administrator in Rhodesia he was directly responsible to Cecil Rhodes for conduct of the colony's business from 1894 to 1897. On his return in 1899 he was appointed Lord Lieutenant of his native Northumberland.