The Popes of the fifteenth century, with the exception of Pope Sixtus IV, showed it great favor. In 1431 a church was built on the place of the hospice's chapel (consecrated by Pope Eugene IV in 1444) and the community was united with the German hospice of St. Andrew which had been founded in 1372 by the priest Nicholas of Kulm. During the fifteenth and sixteenth centuries Santa Maria dell'Anima became the national and religious centre as well as burial place in Rome of the Holy Roman Empire.