Wellsville's first industry was tanning, utilizing the bark of the hemlock tree for its tannins. Three large tanneries operated in Wellsville during the early 19th century. Next came the lumbermen and the railroad. The New York and Erie Railroad came through what would become Wellsville (then the outskirts of Scio) in 1851 as the quickest way west from New York City, crossing New York state. This proved that Nathaniel Dyke's choice of location was the quickest, easiest and most practical way across Allegany County. The trains gave the lumbermen a new and more efficient means to get their product to market. Prior to this, the logs had been floated on the rivers and canals. Logging moved on to more densely forested areas in the latter part of the 19th century but the cleared ground quickly produced excellent grazing for a tremendous dairy industry which followed.