The distinction between powder and single crystal diffraction is the degree of texturing in the sample. Single crystals have maximal texturing, and are said to be anisotropic. In contrast, in powder diffraction, every possible crystalline orientation is represented equally in a powdered sample, the isotropic case. PXRD operates under the assumption that the sample is randomly arranged. Therefore, a statistically significant number of each plane of the crystal structure will be in the proper orientation to diffract the X-rays. Therefore, each plane will be represented in the signal. In practice, it is sometimes necessary to rotate the sample orientation to eliminate the effects of texturing and achieve true randomness.