Entering Milan victorious on 25 March 1450 (the day of Annunciation), the Duke decided to dedicate a charitable institution to Annunciata. It was then that the new foundation became the "Spedale della Nunciata". Designed by the renowned architect Filarete and built by the engineer Guiniforte Solari (responsible for the courtyard of the Certosa di Pavia, a monastery complex in Lombardy, Northern Italy), the hospital formed part of the completion of the reform of hospitals started by the Archbishop Rampini in the years of the Golden Ambrosian Republic.