On 24 October 1962, "Angler" commenced her first deployment to the 6th Fleet and conducted operations in the Mediterranean Sea. In the course of her deployment, she visited ports in Spain, Italy, France, and Greece. She returned to New London on 6 February 1963 and resumed operations with the submarine school. In 1963, "Angler" was redesignated AGSS-240. For the remainder of her career, the submarine continued her pattern of periodic deployments to the Caribbean and West Indies, made midshipman and Naval Reserve training cruises, and operated in conjunction with the submarine school.