A short distance after the Route 38/CR 530 intersection, the route becomes the border between Eastampton Township to the west and Southampton Township to the east before running between Eastampton Township and Pemberton Township. Along this portion, it passes through Ewansville. Continuing entirely into Springfield Township, the route crosses CR 537. Past this intersection, US 206 widens into a four-lane undivided road. The route briefly gains a wide painted median before crossing the Assicunk Creek into Mansfield Township In Mansfield Township, US 206 becomes a divided highway as it bypasses the community of Columbus to the west, with CR 690 continuing through Columbus. On the bypass of Columbus, the route has an interchange with CR 543.