Harris's work in "Jeffrey" led to numerous television guest appearances, including a recurring role on the sitcom "Frasier" as Frasier's conniving agent Bebe Glazer from 1993 to 2004. Harris co-starred in several unsuccessful series, including "The 5 Mrs. Buchanans", "Union Square", "The Beast", and "It's All Relative", but played notable guest roles on multiple hit series, including "Ghost Whisperer", "Murphy Brown", "Ally McBeal", "Six Feet Under", "Frasier" and "Ellen". Among them was her performance on "The X-Files" in the 1993 episode "Eve" as Dr. Sally Kendrick and her "Eve" clones. In 2006, she starred in the Sci-Fi Channel miniseries "The Lost Room" as Margaret Milne.