In 1949, NC 49 was rerouted in Roxboro from Main Street onto newly constructed Madison Boulevard. In 1953, NC 49 was given its modern routing bypassing Concord and a concurrency with NC 73; that same year, in the Charlotte area, it was moved from Old Concord Road to University City Boulevard. Around 1960, NC 49 was given a new alignment south of Farmer, in Randolph County. By 1962, in Roxboro, NC 49 was removed along Morgan Street and Concord Road to an overlap with US 158 on Leasburg Road.