"Angler" began her second war patrol on 15 February, assigned the waters off the east coast of the Philippines in the Mindanao Sea and Sulu Sea. While she was nearing her patrol area, Major General Douglas MacArthur had learned that the Japanese were massacring all the civilians they could find on the island of Panay. MacArthur requested that a submarine be assigned to evacuate what was believed to be about twenty civilians from the island. The task fell to "Angler", and she found 58 men, women, and children awaiting rescue. "Angler" took all of them on board and berthed them in the forward and after torpedo rooms. Meals were limited to two per day in an attempt to stretch the submarine's overtaxed food supply. Toward the end of the cruise, many of the passengers and crew became nauseous. The captain suspected the water supply may have been contaminated, and requested that the fresh water tanks be cleaned upon arrival at Fremantle on 9 April.