The novel focuses on a post-apocalyptic character called "Snowman", living near a group of primitive human-like creatures whom he calls "Crakers". Flashbacks reveal that Snowman was once a boy named Jimmy who grew up in a world dominated by multinational corporations and privileged compounds for the families of their employees. Near starvation, Snowman decides to return to the ruins of a compound named RejoovenEsense to search for supplies, even though it is overrun by dangerous genetically engineered hybrid animals. He concocts an explanation for the Crakers, who regard him as a teacher, and begins his foraging expedition.