On May 30, Pedroia was placed on the 10-day disabled list due to a left wrist sprain. On August 1, he was again placed on the 10-day disabled list due to left knee soreness. On August 12, Pedroia was placed on the disabled list for the third time of the season due to soreness in the same knee. Limited to 105 games, Pedroia finished the 2017 Red Sox season with a .293 batting average, 7 home runs, and 62 RBI. On October 25, it was revealed that Pedroia underwent surgery on his knee for a complete cartilage restoration, meaning that he would miss the start of the 2018 season.