In Brookville, PA 36 has a three-route concurrency with U.S. Route 322 and PA 28 along Main Street. North of the overlap, PA 36 becomes Allegheny Boulevard while interchanging Interstate 80 at exit 78. North of Brookville, PA 36 runs mostly on a northern course. In the northwestern sections of the county, the road intersects PA 949 in Sigel and PA 899 near Clear Creek State Park. PA 36 exits the county running west along the southern tips of the Clarion River in Cook Forest State Park.