Fungicide use often simply is not economical for Septoria Leaf Blotch. The rapid evolution of pathogen resistance to fungicides is a major barrier. "Zymoseptoria tritici" has resistance to multiple fungicides, because it has number of substitutions of CYP51. CYP51 substitutions include Y137F which confers resistance to triadimenol, I381V which confers resistance to tebuconazole and V136A that confers resistance to prochloraz. Chemical control of the pathogen (antifungal medication) now relies on the application of azole fungicides which are demethylase inhibitors that inhibit lanosterol 14 alpha-demethylase (CYP51) activity.