WIS 22 passes northwest of the small communities of Adams Beach and Belle Plaine as it turns northeast and approaches Shawano. WIS 22 junctions with WIS 29 southwest of the city and passes into the city itself along Main Street. The highway turns east onto Green Bay Street, joining WIS 47 and Wisconsin Highway 55 south for two miles (3 km) within the city. WIS 47 and WIS 55 then turn south onto Airport Road and WIS 22 passes northeast around the southeast side of Shawano Lake and through Cecil, junctioning with WIS 117. The highway enters Oconto County at Pulcifer.