Like the "Invincibles" tour, the 1949–50 Test series in South Africa was another triumph for the Australians. They won four of the five Tests and were undefeated in 21 first-class matches. Loxton started the tour strongly, making 117 in the opening match against Zululand, which was not first-class. He continued his productivity in the succeeding games, never failing to pass 40 in any completed innings in the first five first-class matches of the tour. This included an all-round effort of 76 not out and a total of 4/10 in an innings victory over Orange Free State. However, the Victorian's form slumped just before the Tests. He made single figure scores in his last three innings, including in the last match against a South African XI in what was effectively a dry run for the Tests. However, he did take 4/32 for the match.