As the runner-up of the Apertura 2014, Tigres qualified to the 2015–16 CONCACAF Champions League, playing their first match of the tournament on 18 August, only thirteen days after the second leg of the final of the 2015 Copa Libertadores. In the group stage, Tigres defeated A.D. Isidro Metapán at the Estadio Universitario by 2–1, tied by 1–1 against C.S. Herediano at the Estadio Eladio Rosabal Cordero, defeated Isidro Metapan by 2–1 at the Estadio Jorge Calero Suárez and tied at the Estadio Universitario against Herediano by 0–0, securing quarterfinals. Tigres defeated Real Salt Lake by 2–0 in the first leg of quarterfinals and tied 1–1 in the second leg, for an aggregate of 3–1. After a 0–0 draw in the first leg of semifinals against Querétaro, in the second leg Tigres won by 2–0. In the finals against Club América, Tigres fell by 0-2 the first leg at the Estadio Universitario and by 1–2 in the second leg at the Estadio Azteca for an aggregate of 1–4.