Leyden is one of only a handful of towns in Massachusetts which does not have any state routes (nearly half of such towns are on the islands of Nantucket, Martha's Vineyard and the Elizabeth Islands). There are state routes, U.S. routes and interstates in the neighboring towns, with Interstate 91 passing to the south and east of town. The nearest bus and passenger train service is in Greenfield, and the nearest small air service in Turners Falls. The nearest national air service is at Bradley International Airport in Windsor Locks, Connecticut.