Charles Renatus Hicks (December 23, 1767 – January 20, 1827) (Cherokee) was one of the three most important leaders of his people in the early 19th century, together with James Vann and Major Ridge. The three men all had some European ancestry, as did numerous other Cherokee, but they identified as Cherokee. The people had a matrilineal kinship system. These three leaders were among those who urged their people to acculturate to European-American ways, in order to succeed in a rapidly changing world. An increasing number of European Americans were entering their territory.