Strathairn appeared in "We Are Marshall", a 2006 film about the rebirth of Marshall University's football program after the 1970 plane crash that killed most of the team's members; and "Cold Souls", starring Paul Giamatti as a fictionalised version of himself, who enlists a company's services to deep freeze his soul, directed by Sophie Barthes. In 2006 he did a campaign ad for then congressional candidate (now Senator) Kirsten Gillibrand. He reprised his role as Edward R. Murrow in a speech similar to the one from "Good Night, and Good Luck", but was altered to reference Gillibrand's opponent John Sweeney.