Del Castillo made her acting debut in 1978 when she took part in a film called "The Last Escape". She became well known in 1991 when she starred as Leticia in "Muchachitas", a telenovela airing in several Latin American countries. The following year, she went to star in "Mágica juventud". Her other leading roles in 1990s was in "Azul" (1996), long-running "Alguna vez tendremos alas" (1997), and "La mentira". In 1995 she appeared in the music video "Fuego de Noche, Nieve de Día" by Ricky Martin.