The village of Yzquipulas village was founded by the Spaniards between 1560 and 1570, who lived peacefully with the Chorti people of the region. For beginning of the 18th century it was one of the most numerous Spanish communities according to the book of baptisms with a population of 198 people. A century later, the Spanish community reached the 851 inhabitants, representing this to 30% of the total community of Chiquimula who were attracted to the region by the fertility of the valleys.