Nichols began playing on the PGA Tour in 1960 and recorded 12 victories, one of which, the PGA National Team Championship, was not fully recognized until 2012. He was a member of the Ryder Cup team in 1967, and his best year on tour was 1974 when he won twice, earned $124,747 and finished 14th on the money list. Nichols, Jerry Heard, and Lee Trevino were struck by lightning at the Western Open on Friday, June 27, 1975. All three men came back to play professional golf. Nichols has had 12 holes-in-one in his professional career.