The Weequahic High School Indians compete in the Super Essex Conference, which is comprised of public and private high schools in Essex County and was established after a reorganization of sports leagues in Northern New Jersey under the supervision of the New Jersey State Interscholastic Athletic Association (NJSIAA). Prior to the NJSIAA's 2009 realignment, the school had participated in the Hills Division of the Iron Hills Conference. With 276 students in grades 10-12, the school was classified by the NJSIAA for the 2019–20 school year as Group I for most athletic competition purposes, which included schools with an enrollment of 75 to 476 students in that grade range. The school was classified by the NJSIAA as Group I North for football for 2018–2020. The school's athletic teams are called the Indians and its colors are orange and brown.