According to Neil Drumming of "Entertainment Weekly", "Me, Myself and I" is similar to "Say My Name" (2000), in terms of " ... its specificity and earnestness ... " and the way Beyoncé defends " ... her chastity gainst some greedy boy ... ." This was echoed by James Poletti of Yahoo! Music who wrote that the song hints at what is to come as the warbling begins to move into overdrive on " ... a faintly sickly, if admirably slick, ode to that old Destiny's Child staple ... ", independence and self-belief in the face of a cheating man.