Sanchez was announced as the starter for the Eagles in the Week 11 game against the Tampa Bay Buccaneers after it was revealed that Bradford suffered a separated shoulder and a concussion. Sanchez's opening drive was excellent, completing 100% of his passes and ending it with a 39-yard touchdown pass to Josh Huff to make the score 7–0. Sanchez continued to play well for the majority of the 1st half, and threw a second touchdown pass to Darren Sproles, but the Buccaneers offense had already scored 21 points. However, after that drive, Sanchez started to crumble, throwing an interception near the end of the second quarter. Sanchez finished the game with 3 interceptions, 1 of which was returned for a touchdown, in a humiliating 45–17 blowout. His 2 touchdown passes were the only points scored by the offense.