In 836, Biblis had its first documentary mention in the Lorsch Abbey’s "Codex Laureshamensis" under the name "Bibifloz" (“settlement at the water”) when King Louis the German donated his holdings in Biblis, Wattenheim and Zullestein to his faithful vassal Wernher, who in turn bequeathed them to the Lorsch Abbey in 846. From 1461 to 1623, the area was pledged to the Palatinate, and in the Reformation’s wake it became Protestant, although after the retrocession, it became Catholic again. During the Thirty Years' War, the municipality was laid waste several times, and the populace was decimated by the Plague. With Secularization in 1803, the municipality passed to what later became the Grand Duchy of Hesse and was assigned to the district of Worms.