The species' range extends from central Arizona south through south-central Arizona in the United States, to southern Sonora, Mexico, including Isla Tiburón in the Gulf of California and was recently discovered in the southern Peloncillo Mountains of Arizona. The type locality is described as "Sierra Verde and Pozo Verde". The latter is a spring located on the Sonora side of the US-Mexico border, near Sasabe. According to Stejneger (1893), this spring is on the western slope of the southern Sierra Verde, which is also known as the Sierra del Pozo Verde. In these areas, the tiger rattlesnake is observed at elevations from sea level to about Reported occurrences at higher elevations have not been confirmed.