Eskandarian was traded to city rivals Los Angeles Galaxy on July 1, 2009. Chivas USA received allocation money and a third round pick in the 2010 MLS SuperDraft in return. He scored in his debut for the Galaxy on July 4, 2009. The goal was a game winner as Los Angeles beat New England 1-0. Eskandarian scored again in a 3-1 win at New York on July 16, a goal which was nominated for MLS Goal of the Year. However, the 27-year-old was injured early in the second half of the Galaxy's 2-2 draw with AC Milan on July 19 when the ball was inadvertently cleared into his face, causing a concussion and broken nose.