On 12 June 1980, one day after the submission of the patent application, Collen presented the results at the Fifth Congress on Fibrinolysis in Malmö (Sweden) in the presence of Diane Pennica, a young scientist from biotech company Genentech Inc, based in South San Francisco. Collen, KU Leuven and Genentech agreed to collaborate on the production of a recombinant version of t-PA (rt-PA), embarking on a new model for drug development: academic and biotech collaboration, today routine, but at that time a new modus operandi. Within 18 months, Pennica and her team had cloned the cDNA (complementary DNA) of human t-PA messenger RNA and was producing rt-PA in cultures of Chinese hamster ovary cells.