In 2000, Smart was cast as Lana Gardner on the hit show "Frasier", set in her home town of Seattle. She went on to win two Emmy Awards for Outstanding Guest Actress in a Comedy Series. Reflecting on the role, Smart said: "I had loved that role on "Frasier" so much, particularly that first episode. It’s nice to get nominated and win for something you were particularly proud of. At the time I was a little bit snobby about doing guest parts. Based on what I don’t know. It wasn’t something I was seeking. But my agent said, 'You have to read this.' I thought it was hilarious and the show was brilliant so I didn't even hesitate. I remember when we did the table read with the rest of the cast we could hardly get through it we were laughing so hard."