In Rome, Panini earned a name for himself as a decorator of palaces. Some of his works included the Villa Patrizi (1719–1725), the Palazzo de Carolis (1720), and the Seminario Romano (1721–1722). In 1719, Panini was admitted to the "Congregazione dei Virtuosi al Pantheon". He taught in Rome at the "Accademia di San Luca" and the "Académie de France", where he is said to have influenced Jean-Honoré Fragonard. In 1754, he served as the prince (director) of the "Accademia di San Luca".