"Sample" remained in the eastern Pacific into the summer of 1970. On 14 July, she departed Hawaii for her second WestPac deployment. Eight days later, she joined the 7th Fleet; and, on 28 July, she arrived in Subic Bay. On 1 August, she got underway for duty as escort for the aircraft carrier on Yankee Station. She operated with TG 77.5 in Tonkin Gulf until 25 August, then steamed for Taiwan, arriving at Kaohsiung on the 27th. By 5 September, she was back at Subic; and on 15 September, she resumed duty with TG 77.5. On 29 September, she returned to Subic; underwent boiler repairs; and sailed for Okinawa on 3 October. Arriving on 6 October, she continued on to Japan; where, from 19 to 27 October, she participated in joint United States-Japan exercises in the Sea of Japan. A call at Hong Kong followed her departure from Japan; and, on 13 November, she arrived at Keelung, Taiwan. Two days later, she continued on to Sasebo, whence she conducted exercises in the Sea of Japan, then steamed for Yokosuka. On 6 December, she departed the latter port and headed for home.