Holliday hit a grand slam on June 9, 2013, during a seven-run 10th inning against the Reds in an 11–4 victory. He left the July 11 game against the Cubs early because of a tightened right hamstring sustained while running to first base, prompting the Cardinals to place him on the DL. He returned July 27 against the Braves. In another game against the Reds on August 26, Holliday's three-run home run was the longest at Busch Stadium in 2013 at . During the final road trip of the season, he collected 13 hits in 26 at bats. However, back spasms kept him out of several games at the end of the regular season. The Cardinals set an all-time MLB team record by batting .330 with runners in scoring position, and Holliday was fourth in MLB in those situations that year at .390. In all, he finished with 22 home runs, 94 RBI, and a .300 batting average. His MLB-leading 31 double plays grounded into were a career-high and set a new Cardinals' single-season franchise record.