In 2017, Nash was cast in a leading role in the TNT crime comedy-drama series, "Claws", produced by Rashida Jones about a South Florida nail salon. Also in 2017, Nash appeared in Mary J. Blige's music video for "Strength of a Woman". For her dramatic turn in "Claws", Nash has received critical praise. She received a Satellite Award for Best Actress – Television Series Musical or Comedy, as well as another nomination for the NAACP Image Award for Outstanding Actress in a Comedy Series. In August 2018, it was announced that Nash would star in and produce "Naked With Niecy Nash", a late-night talk show for TNT.