A member of the Liberal Party, Loxton entered politics and was a member of the Victorian Legislative Assembly, representing the electoral district of Prahran from 1955 to 1979. During this time, Loxton was also active in cricket administration at club, state and international level. He was a state selector for over two decades, and served at national level for ten years, starting in 1970–71. He was also the team manager for Australia's tour of the subcontinent in 1959–60, overseeing a successful campaign despite a spate of serious illnesses to personnel. Loxton had to deal with a variety of tumultuous events on and off the field during his tenure, often relating to player misconduct, and retired from cricket administration in 1981 following the underarm incident.