Karam rose to stardom throughout the 1990s, earning the moniker, Shams el-Ghinnieh ("The Sun of Song"), from her eponymous album. Her other successful '90s albums include "Naghmet Hob", "Ma Bassmahlak", "Maghroumeh", and "Rouh Rouhi". In 2000, Karam's tenth album "Oyoun Qalbi" became her highest-selling album. In 2001 her album "Nedmaneh" sold millions of copies worldwide, earning Karam a Murex d'Or award for Best Arabic Artist and Rotana Records awards including, Artist of the Year, Album of the Year, and Highest-Selling Album of the Year. By the time her album Saharni was released in 2003, she had established herself as one of the most prominent Lebanese singers and as a Middle Eastern pop icon. Throughout the late 2000s, Karam's commercial success endured via her albums, "Hayda Haki", "Am Bemzah Ma'ak", and "Khallini Shoufak". Karam frequently worked with the renowned musician and composer Melhem Barakat and collaborated with the legendary singer, Wadih el Safi on their critically acclaimed 2004 duet titled, W Kberna ("We Grow Old Together"). In 2011, Karam collaborated with Sony Entertainment and Rotana to produce the Arab World's first 3D music video for her song, "Ma Fi Noum" from her record "Hal Layle... Ma Fi Nom". In 2012, Karam walked the Red Carpet at the 65th Cannes Film Festival. Karam has since released well-received singles and music videos as well as her latest studio album, Menni Elak, in 2017. She continues to perform throughout the Arab world and internationally.