This argument has been formulated by Paul Churchland, among others. The point is that, in instances of some sort of brain damage (e.g. caused by automobile accidents, drug abuse, pathological diseases, etc.), it is always the case that the mental substance and/or properties of the person are significantly changed or compromised. If the mind were a completely separate substance from the brain, how could it be possible that every single time the brain is injured, the mind is also injured? Indeed, it is very frequently the case that one can even predict and explain the kind of mental or psychological deterioration or change that human beings will undergo when specific parts of their brains are damaged. So the question for the dualist to try to confront is how can all of this be explained if the mind is a separate and immaterial substance from, or if its properties are ontologically independent of, the brain.