On January 10, 2013 it was announced that Scott would face off against unbeaten heavyweight contender Vyacheslav Glazkov. The fight took place on February 23, 2013 and ended in a draw, the first blemish on Scott's record. On July 20, 2013 Scott fought Derek Chisora for the vacant WBO International Heavyweight title. The fight took place at the Wembley Arena in London, England and Scott suffered his first defeat, a sixth round knockout. Having been floored, he waited until the referee counted to nine to get up, but was adjudged to have been counted out in the act of rising. On January 24, 2014 Scott beat Grover Young by a stoppage in the second round, before getting knocked out in the first round by Deontay Wilder on March 15, 2014.