Zalishchyky became part of the Tarnopol Voivodeship. Under the Second Polish Republic, Zalishchyky was located in the extreme southeast corner of the country, and developed into a very popular spa, and was dubbed the "Polish Meran" or the "Polish Riviera", especially popular were the sandy beaches located along the Dniester. The town was regarded as the warmest town in Poland and the Polish capital of grapevine, with annual grape festivals taking place here every summer. Zalishchyky had a direct rail connection with Warsaw and Gdynia (the distance of , the longest route in the Second Polish Republic). Furthermore, a luxtorpeda fast train connected Zalishchyky with Ternopil. The town suffered three catastrophic floods in 1863, 1871, and 1927.