In the late 1920s, Lane was reputed to be one of the highest-paid female writers in America and along with Hoover counted among her friends well known figures such as Sinclair Lewis, Isabel Paterson, Dorothy Thompson, John Patric and Lowell Thomas. Despite this success, her compulsive generosity with her family and friends often found her strapped for cash and forced to work on material that paid well, but thus did not engage her growing interests in political theory and world history. She suffered from periodic bouts of self-doubt and depression in mid-life, diagnosing herself as having bipolar disorder. During these times of depression, Lane was unable to move ahead with her own writing, but she would easily find work as a ghostwriter or silent editor for other well-known writers. In 1928, Lane returned to the United States to live on her parents' farm. Confident in her sales of her books and short stories as well as her growing stock market investments, she spent freely, building a new home for her parents on the property and modernizing the farmhouse for herself and a steady stream of visiting literary friends.