On October 16, in Week 6, Brees threw for 465 yards and four touchdown passes with one interception in a 41–38 home win over the Carolina Panthers. With this performance, Brees set an NFL record with the 15th 400-yard passing performance of his career. Brees reached another milestone in the game, becoming the sixth player to record 50,000 passing yards with one team. The other five players are Peyton Manning (Indianapolis Colts), Brett Favre (Green Bay Packers), Dan Marino (Miami Dolphins), Tom Brady (New England Patriots), and John Elway (Denver Broncos).