In Otsego, NY 205 continues to run through mostly undeveloped areas to a junction with NY 80. NY 205 turns eastward here to follow NY 80 while NY 205's former northward right-of-way continues as a town highway named Raymond Fish Road. The two state routes initially head southeastward for roughly ; however, they soon curve to the northeast as they descend into a valley surrounding Oaks Creek, a tributary of the Susquehanna River. At the base of the valley, NY 80 and NY 205 meet NY 28, the primary north–south road through the area. NY 205 terminates here while NY 80 heads southeastward along NY 28, following the route through the hamlet of Oaksville toward Cooperstown.