On September 4, 2010, Gill lost his Kansas home debut to an FCS school (North Dakota State) 6–3. The Jayhawks bounced back the following week to upset No. 15 Georgia Tech 28–25. The upset was a high point in an otherwise difficult 3–9 season. The Jayhawks had one conference win in 2010, a 52–45 comeback win over Colorado after trailing 45–17 in the 4th quarter, with Colorado coach Dan Hawkins calling mostly passing plays to pad stats. It was the final meeting between the teams before Colorado exited the Big 12 for the Pac-12 Conference.