In 1999, female singer Deetah used elements of the song in her single "El Paraíso Rico". The song was sampled by rapper Black Rob, in his 1999 song "Spanish Fly" (included in his "Life Story" album) featuring Jennifer Lopez. In the chorus of the song, Lopez sings the part which samples "La Isla Bonita". Rapper Andre Nickatina sampled the song in "Son of an Angel", which is featured on his 2001 album "Unreleased". In 2004, rapper Mase sampled and interpolated it for his song "My Harlem Lullaby". In 2020 The Black Eyed Peas, Ozuna and J. Rey Soul interpolated the line of "La isla bonita" in their song "Mamacita".