Prestwich, together with Whitefield and Radcliffe, is part of the marginal Bury South Parliamentary constituency, which has been represented by Conservative MP Christian Wakeford since 2019, who gained it from Labour by 402 votes, making it one of the most marginal in the country. It was previously represented by Ivan Lewis who was first elected for Labour in 1997, however due to allegations of indecent behaviour towards women was suspended from the party in 2018 and since resigned from the party to serve as an independent, and stood as an Independent in the 2019 election. Prior to this it was represented by Conservative David Sumberg since the constituency's creation in 1983. Prestwich was previously paired with the neighbouring town of Middleton in the Middleton and Prestwich constituency first created in 1918.