There is no medical treatment that can promote wound healing or regeneration of the corneal endothelium. In early stages of corneal edema, symptoms of blurred vision and episodic ocular pain predominate, due to edema and blistering (bullae) of the corneal epithelium. Partial palliation of these symptoms can sometimes be obtained through the instillation of topical hypertonic saline drops, use of bandage soft contact lenses, and/or application of anterior stromal micropuncture. In cases in which irreversible corneal endothelial failure develops, severe corneal edema ensues, and the only effective remedy is replacement of the diseased corneal endothelium through the surgical approach of corneal transplantation.