U.S. 98 enters the state from the southeast and immediately widens to four lanes. It bypasses Lucedale to the north, and an interchange with Mississippi Highway 63 provides four-laned access to Pascagoula on the Mississippi Gulf Coast, increasing road capacity for hurricane evacuations. At Hattiesburg, an interchange with U.S. Route 49 provides four-laned access to Gulfport (to the south) and Jackson (to the north). The road continues west from its intersection with U.S. 49 to Interstate 59 at Exit 59, with which it is concurrent through Exit 65 (Hardy Street). The highway runs westward through Columbia before meeting U.S. 51 in McComb. It then joins Interstate 55 from Exit 15 (South McComb) to Exit 20 (Summit). The last remaining two-laned section of U.S. 98 in Mississippi then runs northwestward to its terminus near Bude in Meadville at US 84.