Alworth was chosen in the first round (eighth overall) of the 1962 NFL draft by the San Francisco 49ers. The American Football League's Oakland Raiders selected him with their first pick (ninth overall) in the second round of the 1962 AFL Draft, and then traded his rights to the San Diego Chargers in return for halfback Bo Roberson, quarterback Hunter Enis, and offensive tackle Gene Selawski. Alworth opted to sign with the Chargers instead of the 49ers. The Chargers kept Alworth at flanker. His slender build, speed, grace, and leaping ability earned him the nickname "Bambi."