Sala was born on 24 November 1828 in London. His legal father Augustus John James Sala (1789–1829) being the son of an Italian who came to London to arrange ballets at the theatres. His natural father and godfather was Captain Charles "Henry" Fairfield, an acquaintance of his mother, Henrietta Catharina Simon (1789–1860), an actress and teacher of singing. She was the daughter of Catherina Cells, a former slave, and Demerara planter D. P. Simon. His great-grandmother was the Caribbean entrepreneur, Dorothy Thomas. He was at school at Paris from 1839 to 1842, and learnt drawing in London, and in his earlier years he did odd-jobs in scene-painting (for John Medex Maddox at the Princess's Theatre, London) and book illustration. The connection of his mother and elder brother (Charles Kerrison Sala) with the theatre gave him useful introductions to authors and artists.