The geographical area that is now Oxford County was populated with Neutral/Attawandaron longhouse villages for many centuries but was abandoned to First Nations nomadic peoples by the 1650s, as a result of warfare with Iroquois and epidemics resulting from European contact. The land was acquired by the Crown by three treaties, signed in 1792 (by chiefs of the Mississaugas First Nation), in 1796 (by chiefs of the Chippewas First Nation) and 1827 (by chiefs of the Chippewas). They depended for their certainty on an earlier treaty known as the McKee Purchase of 1790, signed at Detroit with 35 chiefs from the Potawatomi, Wyandot, Ojibwe, and Odawa First Nations.