When women members of the House formed a Women's Caucus in 1977, Lloyd was one of three congresswomen who declined membership, presumably because she feared alienating her constituents. She later joined the caucus but resigned in 1980 over political disagreements. Lloyd cosponsored legislation related to women's health, notably the Mammography Quality Standards Act, which was enacted in 1992. After she was diagnosed with breast cancer in 1991 and was denied a silicone breast implant because the U.S. Food and Drug Administration (FDA) had removed them from the market, Lloyd became an advocate for breast cancer treatment and women's health. She advocated for the availability of breast implants for reconstructive surgery. Her fight with cancer led her to reverse her longstanding opposition to abortion; she announced on the floor of the House that having to fight to make decisions about her treatment "that should have been mine alone" led to her change of heart on the issue.