His ODI captaincy first came during West Indies touring third ODI on 22 May 2005, where Pakistan won the match by 22 runs and sealed the series 3–0. He first led Pakistan Test team against the same West Indies tour in 2005, where regular captain Inzamam was given one-Test ban for showing dissent against India. In September 2006, he was offered the position of captain for the 2006 ICC Champions Trophy, following the suspension of Inzamam ul Haq. He turned down the offer, stating he did not want to be a "dummy captain". However, on the morning of 7 October 2006, the Pakistan Cricket Board announced that Khan would lead his team in the tournament. In the series, Pakistan won only one match and lost two, thus quit from the series in the league as well.