Aldrovandi was born in Bologna to Teseo Aldrovandi and his wife, a noble but poor family. His father was a lawyer, and Secretary to the Senate of Bologna, but died when Ulisse was seven years old. His widowed mother wanted him to become a jurist. Initially he was sent to apprentice with merchants as a scribe for a short time when he was 14 years old, but after studying mathematics, Latin, law, and philosophy, initially at the University of Bologna, and then at the University of Padua in 1545, he became a notary. His interests successively extended to philosophy and logic, which he combined with the study of medicine.