US 60 continues on east, paralleling Interstate 64. The route travels through Winchester, and then junctions US 460 in Mount Sterling. After leaving the city, US 60 crosses over to the north side of Insterstate 64, creating an interchange. From here, US 60 travels through the cities of Owingsville, Morehead, and Grayson, before turning northeast to head to the city of Ashland. In the city, US 60 joins US 23, and the two routes head south along the Ohio River. The routes continue to Catlettsburg, where US 60 leaves US 23 and heads east, crossing over the Big Sandy River on the Billy C. Clark Bridge into the state of West Virginia.