The Society was founded by George Crawford Hyndman, James Lawson Drummond, James Grimshaw, James McAdam, Robert Patterson, Robert Simms, Francis Archer, the Thomas Dix Hincks, Edward Hincks and Edmund Getty. Five years later in 1826 Alexander Henry Haliday and William Thompson both joined. In 1823, the Society's collection and the small collection begun in 1788 in the rooms of the Belfast Reading Society and that of the Belfast Literary Society were moved to Belfast Academical Institution where James Bryce was centralising Belfast's rapidly expanding natural history holdings. A new building opened at No. 7 College Square North in 1831.