Prior to the Spanish conquest, the municipality of Villa Guerrero was inhabited by the indigenous Tepecan (Tepehuan). The area was conquered by the Spanish Captain Pedro Almíndez Chirino, sent by Nuño Beltrán de Guzmán in the year 1530. Shortly after the arrival of the Spanish into the area, the Huichol (Wixarika) migrated to the area's remote canyons and mountains. The Spanish settlement of the area at the end of the 16th century brought a number of Tlaxcaltec colonizers to the area.