From 2015 to 2016, Breckenridge portrayed Jessie Anderson, a character from the comic book series of the same name, in season five and season six of the AMC post-apocalyptic horror series "The Walking Dead". In 2015, she co-starred in the psychological thriller "Dark" from executive producer Joe Dante and director Nick Basile. In 2017, Breckenridge appeared in the recurring role of Sophie, Kate's childhood friend and Kevin's ex-wife, in the first season of the NBC drama series "This Is Us". She was promoted to a series regular for the second season, and appeared in one episode in the third season and two episodes in the fourth season.