The film received mixed to positive reviews from critics, and currently holds a 64% rating on Rotten Tomatoes based on 50 reviews. Roger Ebert awarded it an average two stars (out of a possible four) finding some of Waters' satire effective but feeling that Kathleen Turner's decision to portray her character's mental illness with realism instead of in a campy fashion, while brave, made the character difficult to laugh at, writing, "Watch "Serial Mom" closely and you'll realize that something is miscalculated at a fundamental level. Turner's character is helpless and unwitting in a way that makes us feel almost sorry for her—and that undermines the humor. She isn't funny crazy, she's sick crazy."