Early in his career, Bhupinder performed on All India Radio, Delhi. He was also attached to the Delhi Doordarshan Center, Delhi. He learnt guitar and violin. In 1962, music director Madan Mohan heard him at a dinner hosted by Satish Bhatia in his honour (Satish Bhatia was Producer in AIR Delhi and Bhupendra was working under him as a guitarist), and called him to Bombay. He gave him a chance to sing the song "Hoke Majboor Mujhe Usne Bulaya Hoga" with Mohammad Rafi in Chetan Anand's "Haqeeqat". He was given a solo by Khaiyyam in film "Aakhri Khat". Bhupinder voice is one of the most unique in play backing. He has song a few popular duets with Mohammed Rafi and Kishore Kumar.