After the loss, Barrera took a period of inactivity. The former three time world champion fought on June 26, 2010 against Adailton de Jesus of Brazil. The 10 round bout took place at the Alamodome, San Antonio, Texas, United States. The match was an undercard of the "Latin Fury 15" event, which featured Julio César Chávez Jr. vs. John Duddy. Barrera dominated De Jesus for 10 rounds, winning via decision. On February 12, 2011, he fought Jose Arias of the Dominican Republic and scored a TKO in the second round; this was to be Barrera's final fight.