This therapy has been proposed as a primary or adjunct therapy for various diseases, including osteoarthritis, herniated disk, chronic wounds, hepatitis B and C, herpes zoster, HIV-AIDS, multiple sclerosis, cancer, heart disease, Alzheimer's dementia, and Lyme disease, though supportive evidence for some of these applications is limited. The American Cancer Society warned in 2010 that evidence for the efficacy of ozone therapy against cancer is inconclusive, and the therapy may be dangerous. For treatment of HIV/AIDS, although ozone deactivates the viral particles outside the body, well-designed studies have shown there is no benefit for living patients.