He played in small bands in New York clubs, including the Coleman Hawkins orchestra (1944), and he associated with beboppers such as Dizzy Gillespie, Charlie Parker, George Wallington, Oscar Pettiford and Max Roach at the Onyx Club from early 1944. He recorded with the latter under Hawkins on what is said to be the first bebop issue, "Woody 'n You", on February 16 and 22, 1944. In May 1944, he shared tenor duties with Hawkins in the latter's Sax Ensemble, as well as leading his own band on performances at the Three Deuces club. After recording for a number of small labels (Savoy, Jamboree, National, Disc, Arista, Super, American, Hub, Gotham) in this period, Byas had a major hit with "Laura" by David Raksin, the title tune of Otto Preminger's movie of the same name (1944).