He went on to become a successful high school and college coach, at schools such as North Carolina College for Negroes (now North Carolina Central University), Hampton Institute (now University), Tennessee A&I (now Tennessee State University), Kentucky State College (now University) and Cleveland State University. In his early years, his teams were restricted to playing only against other all-black teams. However, while coaching at North Carolina College for Negroes, McLendon participated in "The Secret Game", a match against a team from Duke University, which was the first collegiate basketball contest where blacks and European-Americans competed on the same floor. He led the Eagles to eight CIAA Championships (1941, 1943–44, 1946–47, 1949–50, 1952). McLendon's teams were credited with increasing the pace of the game of basketball from the slow tempo of its early years to the faster tempo that prevails today. At Cleveland State, he was the first African American head coach of a predominantly white university.