It is possible that the Chajoma of Mixco Viejo (Jilotepeque Viejo) initially allied themselves with the Spanish together with the Kaqchikel kingdom of Iximche, and that they also rebelled against the Spanish in 1524. It is known that when the lords of Iximche broke their alliance with the conquistadors, they took refuge in Jilotepeque. The site was abandoned after the Spanish conquest and the inhabitants were moved by the Spanish to San Martín Jilotepeque, after which the area was never reoccupied.