In 1979, Lavoe became deeply depressed and sought the help of a high priest of the Santería faith to treat his drug addiction. After a short rehabilitation, he relapsed following the deaths of his father, son, and mother-in-law. These events, along with being diagnosed with HIV, drove Lavoe to attempt suicide by jumping off a Condado hotel room balcony in San Juan, Puerto Rico. He survived the attempt and recorded an album before his health began failing. Lavoe died on 29 June 1993, from a complication of AIDS.