Metalist's next European competition was the 2008–09 UEFA Cup. The club beat Beşiktaş 4–2 on aggregate in the first round to qualify for the group stage, where they were grouped with Galatasaray, Olympiacos, Hertha BSC and Benfica. Metalist finished top of the group, beating Galatasaray, Olympiacos and Benfica, whilst drawing 0–0 with Hertha. In the round of 32, Metalist defeated Italian club Sampdoria 3–0 on aggregate, setting up for an all-Ukrainian round of 16 tie against Dynamo Kyiv. After losing in Kyiv 1–0, Metalist won the return leg 3–2, but were eliminated on the away goals rule.