Based on data from the 2010 United States Census, the population of Woodlawn-Wakefield was 42,483, a decrease of 1,100 (2.5%) from the 43,583 counted in 2000. Covering an area of , the neighborhood had a population density of . The racial makeup of the neighborhood was 17.6% (7,473) White, 58.3% (24,774) African American, 0.4% (169) Native American, 3.4% (1,465) Asian, 0.0% (20) Pacific Islander, 2.0% (855) from other races, and 2.0% (866) from two or more races. Hispanic or Latino of any race were 16.1% (6,861) of the population.