"Picuda" prepared for active service in the Portsmouth Naval Shipyard until 18 February and shifted to the Submarine Base at New London the next day. In company with five other submarines of the New London Group, she cleared that base 25 February for a tour of duty out of the Submarine Base at Balboa, Panama, returning by way of St. Thomas, to New London on 27 March. "Picuda" again entered the Portsmouth Naval Shipyard for inactivation on 27 March and was towed by a fleet tug to New London on 19 September 1946. She was placed out of commission, in reserve 25 September 1946.