The interior of the Nathaniel Russell house is greatly influenced by the Adam style, popular at the first of the 19th-century, that introduced curved walls, elaborate plasterwork decorations and striking mixed color schemes. The house features three main rooms per floor each of different geometric designs: a front rectangular room, a center oval room, and a square room in the rear. The rectangular entrance hall with a black and white diamond patterned floorcloth edged with a leaf motif, and the adjacent office was where Russell would conduct business. Separating the public rooms at the front of the house from the more private rooms used by the family, wide faux-grained double doors with glazed rosette patterned insets and an elliptical fan shaped transom, gives access to the golden walled stair hall that showcases the most important architectural feature of the house, the cantilevered spiral staircase, that ascends to the third floor. The asymmetrical hall is illuminated by a Palladian window, and further ornamented with trompe-l'œil painting resembling a plaster cornice and an elliptical medallion that were painted by Charleston artisan Samuel O'Hara. Off the central stair hall is the oval dining room, with turquoise walls that appear painted, but are small squares of unpatterned wallpaper bordered with interlocking rings, in red and gold, above cypress wainscoting painted white. The heart-pine floors and the wood interior shutters are original. At the rear of the house is a square parlor, that was enlarged at a later date to connect the house with the kitchen, and was used by the family for everyday dining.