The large rectangular withdrawing room found at the front of the house has soft gray walls and white wainscoting that offsets the multilayered gilded cornice molding. The windows are surrounded with tall slender pilasters and overhanging entablatures, that add dimension to the walls. With windows on three sides, the room was utilized primarily during the day to take advantage of the daylight and breezes. At the rear of the house is the square shaped master bedroom, and additional bedchambers are found on the third floor. Though most of the art and furniture displayed in the house are not original to the Nathaniel Russell House, they are of the correct time period for when the Russell family inhabited the house, and many are of Charleston origin.