In 1938, Avis was diagnosed with tuberculosis. She died later that year, at the age of 58. Of his loss, Blake said, "In my life I never knew what it was to be alone. At first when Avis got sick, I thought she just had a cold, but when time passed and she didn’t get better, I made her go to a doctor and we found out she had TB … I suppose I knew from when we found out she had the TB, I understood that it was just a matter of time."