New York Avenue is U.S. Route 50 from the border with Maryland and into northwest as far west as 6th Street NW. In addition, it is U.S. Route 1 Alternate from Bladensburg Road NE to 6th Street NW. The northern terminus of Interstate 395 is at a signaled intersection with New York Avenue and 4th Street NW. At that intersection, traffic from New York Avenue in either direction may turn south onto Interstate 395, but traffic on northbound Interstate 395 may turn only right (east) onto New York Avenue.