Denizet-Lewis's non-fiction often takes the form of in-depth profiles or exposes, marked by embedded research. His work examines and explicates manifold aspects of what might loosely be called American culture, with a focus on subcultures or groups that are reviled, disliked, or erased. In a review of his work, Publishers Weekly wrote that Denizet-Lewis "offers stirring and sensitive portraits of individuals—frequently adolescents—struggling to articulate desire and identity while bearing the weight of societal taboo and marginalization." Denizet-Lewis is also known for spotlighting trends, such as rising rates of anxiety among young people and the increased prevalence of middle-schoolers coming out as gay or bisexual. He has also written lengthy features about, among other things, addiction, homeless LGBT youth, teen Christians, ex-gays, NAMBLA, Abercrombie & Fitch, LGBT conservatives, and the culture of sports. Denizet-Lewis is also often called upon to profile celebrities, including James Franco, Jake Gyllenhaal, Barry Bonds, Brad Gilbert, Perez Hilton, Barney Frank, and Dr. Drew.