US 60 joins US 31W, and the routes travel north to the city of Louisville. US 60 creates an alternate route, traveling through the south side of Louisville, while US 60 travels through the north side. The routes head north through the city, having an interchange with I-264 along the way. At Bernheim Lane, US 31W splits off US 60 and parallels on the west side, while US 60 continues north, traveling further into the city. US 60 joins US 150, and the routes travel east out of the downtown area. The routes junction US 31E, and US 60 goes north on US 31E, while US 150 goes south on US 31E. Then, US 60 turns off onto US 42, has an interchange with Interstate 64, and then splits off of US 42 and heads out of Louisville. Before leaving, Alternate US 60 joins back, and US 60 has an interchange with I-264 once more, and then with I-265.