In 2007, Pironkova lost in the first rounds of the Australian Open, French Open, and Wimbledon. She played in qualifying rounds for the US Open and beat Zuzana Ondrášková, Marta Domachowska, and Stéphanie Dubois to reach the main draw, and drew Olga Puchkova from Russia in the first round, and won that match to set up a clash with world No. 1, Justine Henin, in the second round. Pironkova lost to Henin in straight sets. After the US Open in September, Pironkova played in one of the biggest Challenger events of the year in Bordeaux, winning the tournament with straight-set victories over Mathilde Johansson, Tatjana Malek and Alizé Cornet.