Farman Farma was in Tehran for only one year, serving first as Minister of Interior. At the end of 1915 he became Prime Minister, but resigned a little more than two months later. The reason for this renunciation was his refusal to sign an agreement allowing Russia and Great Britain to supervise the military and financial affairs of Iran. He asserted then that « it is a shame for the grandson of Crown Prince Abbas Mirza himself to consent to the slavery of Iran by signing such a document ». As a Prime Minister he established the Ministry of Health . Later, in 1924, he would create the Pasteur Institute of Iran whose first action was to introduce a smallpox vaccine . In 1916, as hostile and near anarchic conditions in Fars prevailed, the British convinced the reluctant shah to appoint Farman Farma a second time as governor general of that province. He remained in that capacity for four years, working closely with the British consul-general and with his old friend Percy Sykes.