At the end of the season, Marchisio was the subject of transfer rumours as his present contract was due to expire next summer. On 6 July 2015, however, he signed a five-year extension, keeping him at his hometown club until the 2019–20 season. Marchisio was ruled out for a month after sustaining an injury to an adductor muscle in his right leg in his first league appearance of the season on 12 September 2015, as Juventus drew 1–1 at home to Chievo. On 24 November, Marchisio was nominated for the 2015 UEFA Team of the Year. On 15 March 2016 it was announced Marchisio would miss the second round of 16 leg of the Champions League against Bayern Munich on 16 March due to a muscular problem in his left calf. He returned to action on 2 April, in a 1–0 home victory over Empoli. Two weeks later on 17 April, Marchisio suffered an anterior cruciate ligament injury during Juventus' 4–0 home victory over Palermo after an awkward fall with a challenge on Franco Vázquez, which ruled him out for the rest of the season as well as the upcoming UEFA Euro 2016 tournament. After a successful surgery to his left knee on 19 April, it was confirmed he would be sidelined for six months. After Juventus clinched their record fifth consecutive Serie A title on 25 April, the club's captain and goalkeeper Buffon dedicated the victory to Marchisio.