The Queen makes a return one year later. While attending a student journalism award ceremony with Jimmy Olsen and Cat Grant, Lana suddenly collapses, with blood pouring out her nose. She receives a call from her doctor telling her that he has "bad news" for her. Following another collapse, Lana is taken to hospital and operated on. She apparently dies on the operating table, but her body is later encased in a cocoon by black insect-like creatures, which then starts to crack open. The hospital is soon engulfed by a gigantic cocoon-like structure, and a number of workers as well as the Science Police and the Guardian are taken hostage by an army of giant insects. Supergirl is soon captured and awakens bound and gagged at the feet of Lana, who is now possessed by the Insect Queen. The Queen reveals to Supergirl that during her last encounter with Lana, she injected her with a portion of her DNA and has been slowly taking control of her body for the past year, with the ultimate goal of capturing a Kryptonian to use as a template for an army of hybrid insects. Supergirl breaks free and is able to expel the Queen from Lana's body with help from Kryptonian technology, and Lana returns to her normal state.