The American Cancer Society profile of mangosteen juice states there is no reliable evidence that mangosteen juice, purée, or bark is effective as a cancer treatment in humans. As of April 2013, it also states that the mangosteen "fruit has been shown to be rich in anti-oxidants. Very early laboratory studies suggest it may have promise as a topical treatment for acne. Early small laboratory and animal studies suggest that further research should be done to determine whether it can help to prevent cancer in humans."