Kapoor began his career as a stage actor in 1979 and was noticed in 1984's "Ek Ruka Hua Faisla", directed by Basu Chatterjee and written by elder brother Ranjeet. Annu made his film debut in "Mandi", (directed by Shyam Benegal) in 1983. His career has spanned over 30 years, including Bollywood cinema, television serials and game shows. Kapoor is best remembered for hosting the singing show "Close-Up Antakshari", produced by Zee TV. His performance as an obsessive-compulsive sperm-bank physician in 2012's "Vicky Donor" met with critical and popular acclaim. He worked in the horror TV serial "Kile ka Rahasya" (1989) as a cop who fond of singing. Kapoor has also appeared in "Yamla Pagla Deewana 2".