US 60 becomes an expressway, the Wendell H. Ford Expressway, traversing around the south side of the city of Owensboro. The route serves as the eastern terminus of the Audubon Parkway (future I-69 spur), as well as the northern terminus of US 431. US 231 joins US 60 and the routes serve as the northern terminus of I-165 (formerly the William H. Natcher Parkway). The routes travel north, leaving Owensboro, towards Maceo. At Maceo, US 60 splits from US 231 and heads east along the Ohio River traveling through the cities of Lewisport, Hawesville, and Cloverport. The route then goes southeast to Hardinsburg, and then traverses northeast to US 31W north of Fort Knox.