Dapagliflozin can cause dehydration, serious urinary tract infections and genital yeast infections. Elderly people, people with kidney problems, those with low blood pressure, and people on diuretics should be assessed for their volume status and kidney function. People with signs and symptoms of metabolic acidosis or ketoacidosis (acid buildup in the blood) should also be assessed. Dapagliflozin can cause serious cases of necrotizing fasciitis of the perineum (Fournier's Gangrene) in people with diabetes and low blood sugar when combined with insulin.