After ingesting psilocybin, a wide range of subjective effects may be experienced: feelings of disorientation, lethargy, , euphoria, joy, and depression. In one study, 31% of volunteers who had been given a high dose reported feelings of significant fear and 17% experienced transient paranoia. In studies at Johns Hopkins, among those given a moderate dose (but still enough to "give a high probability of a profound and beneficial experience") negative experiences were rare, whereas 1/3 of those given the high dose experienced anxiety or paranoia. Low doses of the drug can induce hallucinatory effects. Closed-eye hallucinations may occur, in which the affected individual sees multicolored geometric shapes and vivid imaginative sequences. Some individuals report experiencing synesthesia, such as tactile sensations when viewing colors. At higher doses, psilocybin can lead to "Intensification of affective responses, enhanced ability for introspection, regression to primitive and childlike thinking, and activation of vivid memory traces with pronounced emotional undertones". Open-eye visual hallucinations are common, and may be very detailed although rarely confused with reality.