Z.501's were used for search-and-rescue missions and anti-submarine patrols. The Z.501 was put into service with some modifications, including; turrets for the machine guns, and some reinforcement of the airframe that increased the overall weight by 500 kg (1,100 lb). The more powerful 656 kW (880 hp) Isotta Fraschini Asso XI.RC engine was fitted, but even with an additional 97 kW (130 hp), the maximum speed dropped to 245 km/h (152 mph), cruise speed to 200 km/h (120 mph), and range to 2,400 km (1,500 mi).