The Asilomar Conference on Recombinant DNA took place at the Asilomar Conference Center on California's Monterey Peninsula in 1975. The main goal of the conference was to address the biohazards presented by recombinant DNA technology. During the conference, the principles guiding the recommendations for how to conduct experiments using this technology safely were established. The first principle for dealing with potential risks was that containment should be made an essential consideration in the experimental design. A second principle was that the effectiveness of the containment should match the estimated risk as closely as possible.