Binding with the ligand causes conformational change in the receptor, which leads to further transmission of signaling. Due to conformational change, the receptor may either show an enzymic activity (called enzymic receptor), or a ion channel opening or closing activity (called a channel receptor). Sometimes the receptors themselves do not contain enzymatic or channel-like domains but they are linked with enzyme or transporter. Some receptors (like the nuclear-cytoplasmic superfamily) have a different mechanism. Once they bind with signal, they change their DNA binding properties and cellular localisation to the nucleus.