The song reached number one on the Irish Singles Chart in its first week of release, due to download sales alone. "Run" remained on the top position the four weeks in total. On 7 December 2008, it entered the UK Singles Chart at number one, also on downloads alone, making it her 3rd number one. It had become the fastest-selling UK download ever after it sold 69,244 in just two days, a record it held until December 2009. By the end of the first week, download sales had reached 131,593, some 8,000 below the first week sales of "A Moment Like This". The single spent a second week at number one in the United Kingdom, before 2008's "The X Factor" winner Alexandra Burke charted with "Hallelujah". "Run" re-entered The Official UK Top 40 at 32 on 15 March 2009. As of January 2021, the song has shifted over 1.2 million copies and is certified x2 platinum in the UK.