After the election, she was appointed to the Health Select Committee serving till December 2006. During the 2005-2010 parliament, Milton worked as the Shadow Minister for Tourism from November 2006 and then the Shadow Minister for Health in July 2007. In February 2006, Milton was among a minority of Conservative MPs to oppose exceptions for private clubs from the proposed Smoking ban in England. Milton had previously announced her opposition to a partial ban, stating it was "the worst possible solution".