In November 1948, Willis faced Republican opposition from a wealthy New Iberia businessman. Jean (pronounced JOHN) Paulin Duhe (1885–1961), was the president of the New Iberia National Bank, head of the Duhe-Bourgeois Sugar Company, president of the Edmundson-Duhe rice mill, third vice-president of the American Sugar Cane League, and the president of the St. Martin-Iberia-St. Mary Flood Control Association. Willis defeated Duhe, 26,587 votes (66.6 percent) to Duhe's 13,337 ballots (33.4 percent). Duhe's margin was similar to that of a previous Republican candidate in the Third District, David W. Pipes, Jr., who contested the position in 1940, when he was defeated by Domengeaux.