"Picuda" spent much of her sixth war patrol on lifeguard station off the coast of China. She got underway from Pearl Harbor 15 March and cleared the replenishment base of Apra Harbor, Guam on 29 March. She entered her patrol area off Kii Suido on 2 April for uneventful lifeguard duty in support of B-29 Superfortress strikes. On 6 May, "Picuda" made rendezvous with sister ship off the Nansei Shoto and received five crewmen from an Army B-29 bomber and debarked these survivors at Tanapag Harbor on 10 May, transferring them to the Headquarters of the Twenty-First Bomber Command. After voyage repairs alongside submarine tender , she departed 11 May for the East Coast of the United States. She stopped at Pearl Harbor, San Francisco, California, and transited the Panama Canal to arrive at the Portsmouth Naval Shipyard, Kittery, Maine, on 22 June.