In 2000, Al Gore won Wilkinson County by a margin of 1.3%, or 84 votes, receiving 50.4% to George W. Bush's 48.1%. The county then voted for all three Republican nominees from 2004 to 2012, each time by a margin of less than 1.5%. In 2016, it voted for Donald Trump by a margin of just over 10%. Wilkinson was thus one of many counties in Georgia's historic black belt that demonstrated a significant swing in favor of Republican presidential candidates from 2012 to 2016. Similarly, the county swung from a 0.25% victory for the 2014 Democratic gubernatorial nominee to an 11.63% victory for the 2018 Republican gubernatorial nominee.