Salfit was incorporated into the Ottoman Empire in 1517 with all of Palestine, and sherds from the early Ottoman era have been found. In 1596 the village appeared in Ottoman tax registers under the name of "Salfit al-Basal" as being in the "Nahiya" ("Subdistrict") of Jabal Qubal, part of the Sanjak of Nablus. It had a population of 118 households and 2 bachelors, all Muslim. The villagers paid a fixed tax rate of 33,3% on various agricultural products, such as wheat, barley, summer crops, olives, goats and/or beehives, in addition to "occasional revenues"; a total of 7,618 akçe.