The Sprain Brook Parkway, designated by the New York State Department of Transportation as NY 987F, a state reference route, begins at a fork from the Bronx River Parkway along the latter's right-of-way along the Bronx River in the city of Yonkers. Crossing through the Northeast Yonkers neighborhood as a six-lane freeway design, the Sprain Brook crosses an interchange with NY 100 (Central Park Avenue) south of Andrus Park. Bending to the north through Yonkers, the Sprain Brook reaches an interchange with Tuckahoe Road, with the northbound and southbound lanes splitting around the Grassy Sprain Reservoir. The two directions bend northeast along the reservoir. The southbound lanes cross Sprain Ridge Park, while the northbound lanes cross through a golf course. Leaving Yonkers for the town of Greenburgh, the lanes of the Sprain Brook come back together, reaching an interchange with Jackson Avenue. The six lane parkway continues northward and to the northeast through Greenburgh, crossing under Ardsley Road. After turning northward once again, the Sprain Brook crosses under a former alignment of NY 131 (Underhill Road) and passes by the Sunningdale Country Club.