The borough was founded in 1790 by Jacob Ake. Originally called Aketown, it is the oldest borough in the current borders of Blair County. The name change was in honor of William Ake, Jacob's son. By 1810, there were 34 houses in the village; the census of 1820 notes an inn, a distillery, and the presence of one slave. The Main Line of the Pennsylvania Canal was completed in 1832, and opened on November 28 when the packetboat "John Blair" left Huntingdon, for the west. The Blair County Children's Home was located in Williamsburg for many years until its destruction by fire. Today, the borough is approximately 30 blocks, centered on High and Second Streets. This comprises the Williamsburg Historic District, listed by the National Register of Historic Places in 1995. Nearby places also listed are: Etna Furnace and the Daniel Royer House.