On July 8, 2018, a Strike Witches anime project titled Strike Witches: 501st Joint Fighter Wing Take Off! was announced as part of the World Witches Series to commemorate the franchise's tenth anniversary. The 12-episode anime adaptation is based on the 2011 comedy spin-off 4-koma manga series by Makoto Fujibayashi. It aired from April 9 to June 25, 2019 on Tokyo MX, TV Aichi, MBS and BS11. The original cast of Strike Witches returned to reprise their roles. Acca effe and Giga Production are animating the series with Fumio Ito as director. Seiko Nagaoka, returned from Brave Witches to produce the music at Nippon Columbia. Production I.G and Anime Beans have been credited for animation production assistance. Funimation has acquired the licence to stream the series with English subs the same day as Japan, with an English dub set for premiere on April 23. The spin-off also received a 30-minute nation-wide theatrical release planned for October 4 with returning cast and production committee from the spin-off TV show. A new anime series titled "World Witches Take Off!" aired from January 13 to March 31, 2021, with the cast and staff from "Strike Witches: 501st Joint Fighter Wing Take Off!" reprising their roles. The series will run for 12 episodes. Crunchyroll streamed the series with English subtitles.