The school is mainly two storeys throughout, except for the northeast corner where it features a basement in which the classrooms are almost exclusively for mathematics. It has an auditorium. It used to feature a single gymnasium in the centre of the school, but an extra one was built and opened in 2002–2003. Sports teams play under the moniker/nickname "Notre Dame Eagles" (formerly the Notre Dame Silver Eagles). The present site at 710 Broadview was once the site of Highland Park Technical School. Notre Dame High School moved into the 710 Broadview site during the mid-1990s, from their old site on the north west corner of the Holland Ave-Queensway intersection. That site is now Fisher Park Public School.