In B.E. 2321, during the Thonburi Period when King Taksin the Great extended his forces into the area of the Mekong River, he ordered Phra Mahakasut Suek and Chao Phya Chakri to dispatch their troops to the banks of the Mekong in order to suppress and unify the lords of all the realms great and small there on both sides of the Mekong together under the reign of the Kingdom of Thonburi, declaring Lord Chanthakinnaree the Phya Chanthasrisuraja Uparaja Mandhaturaj (พระยาจันทรศรีสุราชอุปราชามันธาตุราช), the first Lord of the Realm of Mukdahan and thereby officially naming the realm "Mueang Mukdahan".