Squee's next door neighbor is Johnny C, aka "Nny" (pronounced knee), the main character of the series. "Nny" regularly visits Squee late at night by breaking into his room. The series focused more on the 'mentoring' or 'big brother' aspect of "Nny" and Squee's relationship, but little interaction occurs in "Squee!", aside from the occasional drawing or note left in Squee's room, or short references to 'the crazy neighbor man' (he does appear as an out-patient of "Defective Head Meat Institute", who Squee is oddly pleased to see). Squee has only one friend, albeit a possibly imaginary one, the dilapidated teddy bear affectionately referred to as Shmee. Only one real person makes any attempt to befriend Squee, a boy named Pepito who happens to be the Antichrist. During the course of the series, Squee encounters a killer chihuahua (that fatally mauls the only classmate who was friendly to him), zombified classmates, sporting mishaps, alien abductions, near recruitment into Satan's army, an encounter with his future self, a ghostly visitor, a giant murderous dust mite, and eventual committal to a mental institution despite being one of the most sane characters in the comic. These experiences lead him to remark to a 'lamb-baby-dog-thing' in one strip that some bitter cartoonist must be drawing his life and therefore he doesn't want to get too attached to anyone or anything in it.