In January 1943, he was promoted to major general and assumed command of the Thirteenth Air Force, and that same November he traveled across the world to take over the Fifteenth Air Force from Jimmy Doolittle. On 1 February 1943, the U.S. Navy rescued Brig. Gen. Twining, the 13th Air Force Commander, and 14 others near the New Hebrides. They had ditched their plane on the way from Guadalcanal to Espiritu Santo and spent six days in life rafts. When Germany surrendered, Arnold sent Twining back to the Pacific to command the B-29s of the Twentieth Air Force in the last push against Japan, however he was in this command only a short time when the atomic strikes ended the war. On 20 October 1945, Twining led three B-29s in developing a new route from Guam to Washington via India and Germany. They completed the 13,167-mile-trip in 59 hours, 30 minutes. He returned to the States where he was named commander of the Air Materiel Command, and in 1947 he took over Alaskan Air Command.