Biffle began the pre-season with an announcement that he would stay at Roush Fenway Racing to help the team with new sponsor Ortho. Biffle began 2015 with a 10th-place finish in the Daytona 500. Unfortunately, that was as good as it could get for Biffle as he faded outside the top twenty in points. He struggled mightily before picking up a second-place finish in the 2015 Coca-Cola 600, after starting fourth. He went on to pick up a fifth-place finish at Pocono in the 2015 Windows 10 400 and a fourth-place at New Hampshire in the 2015 Sylvania 300, finishing twentieth in points.