In his five seasons at Siena, McCaffery guided the Saints to four 20-win seasons, including three consecutive MAAC Regular-Season and Conference Tournament Championships. These resulted in three consecutive berths to the NCAA Tournament, in which they defeated both Vanderbilt and Ohio State in the first rounds. McCaffery's tenure at Siena is considered the greatest in program history as he revived a program that had a record of 6–24 prior to his arrival. He also maintained a 100% graduation rate for players completing their NCAA eligibility. McCaffery was introduced as the head coach of the Iowa Hawkeyes on March 29, 2010.