Pironkova began her 2017 campaign with a second-round appearance at the Shenzhen Open, where lost to the eighth seed and eventual finalist, Alison Riske, having beaten Galina Voskoboeva in her opening match. She next played in the qualifying rounds at the Apia International Sydney. She defeated Patricia Maria Tig in the first round, only to retire in her next match against Maria Sakkari. Pironkova entered the Australian Open as the 64th ranked player, and lost in three sets against the third seeded Agnieszka Radwańska as her first round opponent. The tournament marked Pironkova's 45th consecutive Grand Slam appearance, the second longest active streak on the WTA Tour only behind Jelena Janković's 51. Pironkova's next tournament was the Qatar Open where she competed in the qualifying competition. She breezed through the first two rounds with straight set wins over Vania King and Evgeniya Rodina. However, in the final round of qualifying, she lost to former world No. 1, Jelena Janković, in three hard fought sets.