Since 2003, Jovovich has worked with musician Maynard James Keenan, of Tool and A Perfect Circle, on his Industrial side project Puscifer, contributing vocals to the track "REV 22:20", which was featured on various film soundtracks in its original or a remixed form. As of January 2009, she can be heard collaborating with Maynard and Danny Lohner on the Puscifer track called, "The Mission." She also performed the song at the first live Puscifer performance on February 13, 2009 in Las Vegas, Nevada. Danny Lohner, and longtime music collaborator Chris Brenner currently continue to record and perform with Jovovich who has made several highly praised appearances in recent years.