The Red Ghost and his Super-Apes, as he called them, battled the Fantastic Four soon after gaining their powers, first meeting the Thing. Red Ghost encountered Uatu the Watcher during this fight, who said he would bring the two warring groups together in a fight for supremacy over the Moon. The Red Ghost and his apes first defeated the Four and kidnapped the Invisible Girl. But he was defeated by the Fantastic Four and left on the Moon when the apes rebelled against him after the Invisible Girl deactivated a force field, allowing them access to the food the Red Ghost kept from them. Mikhlo then broke down the metal door, freeing the Invisible Girl. The Red Ghost got into the Watcher's base hoping to use his secrets, but was unable to understand the technology, and was thrown from the area by the Watcher. The Fantastic Four then used a paralyzing ray to stop him.