In 1911, Jouett Shouse moved to Kinsley, Kansas, where he married. He became involved in agricultural and livestock businesses and served on the board of directors of the director of the Kinsley Bank. He was elected a state senator in 1913 then in 1915 was elected to the United States Congress where he served until 1919 when President Woodrow Wilson appointed him as Assistant Secretary of the Treasury. At the Treasury Department he was in charge of customs, internal revenue and reorganized the War Risk Insurance division until November 15, 1920 when he resigned "in order to adjust his personal affairs."