US 60 parallels Interstate 64 as the route travels east through Shelbyville, and on into the capital city of Frankfort. Here, US 60 junctions US 127, and heads on east into the city. US 60 crosses the Kentucky River and continues east to US 421 and US 460. US 60 joins US 421, and the routes travel south for a bit, and then US 421 splits off of US 60 and heads east. US 60 heads southeast, crossing over to the south side of Interstate 64. US 60 joins US 62 once again in a strange concurrency (US 60 is heading east while US 62 is heading west, and vice versa). US 60 quickly splits off at Versailles, and then the route travels east towards Lexington.