Massino first met his future wife Josephine Vitale in 1956, and married her in 1960. The couple had three daughters. Massino also befriended Josephine's brother, Salvatore Vitale, who, after briefly serving in the Army, became one of Massino's most trusted allies. While athletic in youth, Massino was an avid cook, and grew overweight in adulthood. His weight gained him the nickname "Big Joey", and during a 1987 racketeering trial, when he asked FBI agent Joseph Pistone who was to play him in a film adaptation of his undercover work, Pistone joked that they could not find anyone fat enough. By 2004, Massino was suffering from diabetes and high blood pressure as well.