"Duke of Edinburgh" rejoined the 1st Cruiser Squadron, which had been transferred to the Grand Fleet in the meantime, in December 1914. In March 1916 the ship had her main deck 6-inch guns removed and the openings plated over. Six of the guns were remounted on the upper deck, three on each side, between the wing turrets, protected by gun shields. At the Battle of Jutland on 31 May 1916, the 1st Cruiser Squadron was in front of the Grand Fleet, on the right side. At 5:47 p.m. The two leading ships of the squadron, the flagship, , and , spotted the German II Scouting Group and opened fire. Their shells felt short and the two ships turned to port in pursuit, cutting in front of the battlecruiser , which was forced to turn away to avoid a collision. "Duke of Edinburgh" could not follow the first two ships and turned to port (northeast). The ship spotted the disabled German light cruiser at 6:08 and fired twenty rounds at her. By about 6:30 she had steamed to a position off the starboard bow of , the leading ship of the 2nd Battle Squadron, where her funnel smoke obscured the German ships from the foremost dreadnoughts of the 2nd Battle Squadron. A torpedo attack by German destroyers on Admiral Beatty's battlecruisers, failed, but forced "Duke of Edinburgh" to evade one torpedo at 6:47. The ship reported a submarine sighting at 7:01, although no German submarines were operating in the area. She fired at another false submarine contact between 7:45 and 8:15.