She founded the Woman's Institute of Domestic Arts and Sciences in Scranton, Pennsylvania. An expert on fashion, Picken was an authority on dress, fabric, design, and sewing. She taught "Economics of Fashion" at Columbia University and was one of the five founding directors of the Metropolitan Museum of Art's Costume Institute. She was the first woman to be named a trustee of the State University of New York's Fashion Institute of Technology, by Thomas E. Dewey, the Governor of New York, in 1951.