Amalga was developed initially as Azyxxi by doctors and researchers at the Washington Hospital Center emergency department in 1996. After heavy adoption, in 2006 it was acquired by the Microsoft Health Solutions Group as part of a plan to enter the fast-growing market for health care information technology. It was adopted at a number of leading hospitals and health systems across America including St Joseph Health System, New York Presbyterian Hospital, Georgetown University Hospital, Johns Hopkins, the Mayo Clinic and five hospitals in the MedStar Health group, a nonprofit network in the Baltimore-Washington, D.C. area.