The recent discovery of another parallel between "Rickettsia" and viruses may become a basis for fighting HIV infection. Human immune response to the scrub typhus pathogen, "Orientia tsutsugamushi", appears to provide a beneficial effect against HIV infection progress, negatively influencing the virus replication process. A probable reason for this actively studied phenomenon is a certain degree of homology between the rickettsiae and the virus, namely, common epitope(s) due to common genome fragment(s) in both pathogens. Surprisingly, the other infection reported to be likely to provide the same effect (decrease in viral load) is the virus-caused illness dengue fever.