After another injury-plagued season, Harden started off the 2008 season with a strong start against the Boston Red Sox, pitching six strong innings and giving up a run and three hits while walking three and striking out nine batters. However, after his second start, he was again placed on the disabled list. Harden was activated on May 11 and struggled in his return allowing 8 hits and 5 runs in 3.2 innings and earning a no decision. In Harden's next start against his former teammate Tim Hudson and the Atlanta Braves, he pitched 7 innings only allowing 4 hits and 1 run while earning the win. In this start against the Braves on May 17, Harden also achieved his first major league hit.