Hambrick was signed as an undrafted free agent by the Dallas Cowboys after the 2000 NFL Draft on June 1. On August 27, he was waived and signed to the practice squad two days later. On December 8, he was promoted to the active roster. In the season finale against the Tennessee Titans, he replaced starter Emmitt Smith in the fourth quarter and led the team in rushing with 6 carries for 28 yards (4.7-yard average). He finished the season with 3 special teams tackles.