"Run" became Lewis's fifth UK Top Five single; it follows "A Moment Like This" which peaked at number one in 2006 and "Bleeding Love" in 2007. In 2008, the double A-side "Better in Time"/"Footprints in the Sand" peaked at number two, while "Forgive Me" peaked at number five. As of December 2013, Lewis holds the record for British female solo artist with the most UK Top 5 singles, with eight. "Run" was certified x2 platinum by the British Phonographic Industry (BPI) and BRIT Certified in January 2021, denoting shipments of more than 1.2 million copies. According to the Official Charts Company, the song had sold 832,000 copies in the UK as of January 2014.