The Cuban tree frog is known to hitchhike on shipments of potted plants, vegetation, packaging, boats, and other motorized vehicles. Once in a new location, the frogs become an invasive species. In Puerto Rico, they have become a predator of the endemic coquí frog. They have several good colonizing traits, such as high fecundity, short generation time, a diverse diet, good competitive ability, and the ability to coexist with humans. In addition, they also secrete a toxic mucus from their skin which helps to limit the number of natural predators.