Around 12,000 years ago, Native Americans began migrating into Florida. An estimated 20,000 Native Americans lived in South Florida when the Spanish arrived. Their population diminished significantly by the 18th century, due to warfare, enslavement, and diseases from Europe. In 1513, Juan Ponce de León, who led a European expedition to Florida earlier that year, became the first non-Native American to reach Palm Beach County, after landing in the modern-day Jupiter area. Among the first non-Native American residents were African Americans, many of whom were former slaves or immediate descendants of former slaves. Runaway African slaves started coming to what was then Spanish Florida in the late 17th century and they found refuge among the Seminoles. During the Seminole Wars, these African-American slaves fought with the Seminoles against White settlers and bounty hunters. Portions of the Second Seminole War occurred in Palm Beach County, including the Battle of Jupiter Inlet in 1838.