 15 begins at an intersection with DE 14 and Holly Hill Road west of the city of Milford in Kent County and proceeds northwest on two-lane undivided Canterbury Road. The road runs through a mix of farmland and woodland with some homes, crossing Ward Branch, Browns Branch to the east of McCauley Pond, Carpenter Bridge Road, and the Murderkill River to the east of Coursey Pond. The route intersects DE 12 and heads across Pratt Branch before it runs to the east of Henderson Aviation Airport. DE 15 crosses Hudson Branch and reaches the community of Canterbury, where it passes homes and crosses Irish Hill Road before it comes to an intersection with US 13.