In 2009, Wake signed with the Miami Dolphins and remained with the team until 2019, when he signed with the Tennessee Titans. Throughout his career, Wake has established himself as one of the premier edge rushers in the NFL. He has been selected to five Pro Bowls (four at defensive end, one at outside linebacker), and is a four-time first or second team All-Pro. His 98 sacks with the Dolphins rank him second all-time in club history to Pro Football Hall of Famer Jason Taylor's 131 sacks, and his 100.5 career sacks also rank second all-time as an undrafted free agent behind John Randle's 137.5.