From 2004 to 2012, Gupta was appointed at the Eller College of Management at the University of Arizona as the Thomas R. Brown Professor of Management and Technology, Professor of Entrepreneurship and MIS; and Senior Director for Research and Business Development. In this role, he has established dual degree programs with the Colleges of Agriculture, Science, Engineering, Medicine, and Optics. The program was designed to lead to two graduate degrees and a certificate in entrepreneurship. Gupta played a significant role in creating the vision for new interdisciplinary research initiatives, such as the proposed multi-college endeavor that would enable United States and Mexico to enhance healthcare in bordering areas through mutual cooperation without investing any additional funds. Another potential endeavor involves the creation of a new International Center of Excellence funded entirely through private donations.