Orlovsky made his first career NFL start on October 12, 2008, in a 12–10 Lions loss against the Minnesota Vikings. He completed 12 of 21 passes for 150 yards, with one touchdown and no turnovers. However, early in the first quarter when he lined up in shotgun formation, he inadvertently ran out of the back of his own end zone for a safety, in what turned out to be the margin of victory. "When they started blowing the whistle, I was like, 'Did we false start, or were they offsides or something?'" Orlovsky said. "And I looked, and I was just like, 'You're an idiot.'"