Immediately after entering Howard County, Route 87 leaves the concurrency to the west, and less than a mile thereafter, U.S. 40 leaves the concurrency to the east. From there, Route 5 continues north to Fayette, in which it forms a nine-mile concurrency with Route 240 that starts with a north-south alignment, but becomes an east-west alignment after intersecting Route 3. Shortly thereafter, Route 240 leaves the concurrency to the south (ultimately heading west), and Route 5 enters Glasgow, after which it returns to a north-south alignment and enters Chariton County.