On 1503 Pope return Camerino to Juan Maria Varano in quality of Lord under Papal dukedom domine. On 1521 Juan, Lord of Camerino was deposed by his brother Segismund and he was reposed again in 1522. On 1534 Camerino is integrated to Dukedom of Spoleto but the ruler and Lady of Camerino was deposed by Pope on 1535, date in which is returned in quality of Marquissate to Ercole Varano for return to the Pope again in 1540 who gave Camerino to Octavio Farnesio, Duke of Parma.