She co-starred in the sitcom "The Millers" on CBS. In 2015, she began a recurring role as Ruth Eastman, Peter Florrick's new campaign manager on "The Good Wife". Martindale took up the role of Ruth again in 2018 in season two of "The Good Fight", the sequel to "The Good Wife". She appears as a fictionalized version of herself on the Netflix animated comedy "BoJack Horseman". Her fictional version is easily angered and temperamentally violent, moonlighting as a bank robber and going on frequent criminal heists. BoJack consistently refers to her as "Esteemed Character Actress Margo Martindale", while most other characters begin addressing her with "Beloved."