In the Saints' regular season opener against the Tampa Bay Buccaneers and their new quarterback Tom Brady, Brees completed 18 of 30 passes for 160 passing yards and 2 touchdowns, breaking Brett Favre's record for most career pass attempts in the process, as the Saints won by a score of 34–23. In Week 2, against the Las Vegas Raiders on "Monday Night Football", Brees threw for 312 yards, one touchdown, and one interception during the 34–24 loss. In Week 3, against the Green Bay Packers on "Sunday Night Football", Brees threw for 288 yards and three touchdowns during the 37–30 loss. In Week 5 against the Los Angeles Chargers on "Monday Night Football", Brees threw for 325 yards, one touchdown, and one interception during the 30–27 overtime win. In Week 9, against the Tampa Bay Buccaneers on "Sunday Night Football", he passed for 222 yards and four touchdowns in the 38–3 victory.