On September 20, 2015, Morales hit three home runs (which tied a Royals record), and had 15 total bases (which set a Royals record) in a 10–3 Royals win over the Detroit Tigers. He was just the third player to homer three times at Comerica park, despite driving in just three runs on the day. He went 4–4 with 3 homers, a triple, and a walk. On October 14, in the winner-take-all game 5 of the American League Divisional Series against the Houston Astros, Morales hit a three-run homer in the eighth inning to secure a 7–2 Royals win.