On television, she played the character Allison DuBois—based on the author and medium Allison DuBois, who claims to have psychic abilities—in the supernatural drama series "Medium" (2005–2011). She won the Primetime Emmy Award for Outstanding Lead Actress in a Drama Series in 2005, from two nominations she received for the role, in addition to three Golden Globe Award and Screen Actors Guild Award nominations. Arquette also appeared in the "CSI" franchise as Avery Ryan, the Deputy Director of the FBI, starring in "" (2015–16). She went on to star as Joyce Mitchell in the Showtime miniseries "Escape at Dannemora" (2018), winning the Golden Globe Award and Screen Actors Guild Award for Outstanding Performance by a Female Actor in a Miniseries or Television Movie, and as Dee Dee Blanchard in the Hulu anthology series "The Act" (2019), winning the Golden Globe Award and Primetime Emmy Award for Outstanding Supporting Actress.