In Jones's sophomore season, he totaled career-high 62 tackles, one sack, one forced fumble, 12 deflected passes, four interceptions, 130 return yards, one interception touchdown, 14 passes defended (second-team), 440 punt return yards and tied for NFL-high with three punt return touchdowns. The three punt returns also tied the franchise record with Billy "White Shoes" Johnson, which was set in 1975. His 12.9 yards per punt return average led the NFL, edging out Chicago's Devin Hester by 1/10 of a yard, while his 26.1 yards per kick return average ranked seventh in the league and sixth in the AFC. Jones also caught two passes on offense for 31 yards (one for 17 yards) and rushed twice for eight yards. His best performance came against the Jacksonville Jaguars in week 15, when Jones had an 83-yard interception return for a score, a 70-yard kick return, and broke up a touchdown pass to Matt Jones to save the game. Jones broke out in his fifth game of the season against the Indianapolis Colts, when he recorded a season-high five tackles and defended a pass in the 14–13 loss. The next week against the Washington Redskins, Jones recorded four tackles and stripped the ball from Antwaan Randle El for the first forced fumble of his career. The next week against Houston, Jones tied a career-high tackle total with eight, and picked off a Sage Rosenfels pass for his first career interception, and also posted his second touchdown on a punt return in his career in the fourth quarter with a 53-yard return. Two weeks later, against the Eagles, Jones recorded his second punt return for a score of the season, a 90-yard run, breaking Billy Johnson's 87-yard franchise record. The next week against the New York Giants, Jones picked off an Eli Manning pass in the fourth quarter that sparked the Titans' 21-point comeback. Against the New England Patriots in the last game of the season, Jones totaled 259 return yards (the NFL's highest total since 2006) along with a punt return score.