On December 2, 2015 it was announced that Mosley would next fight 37 year old Venezuelan veteran Patrick López (23-6, 14 KOs) at the Roberto Durán Arena in Panama City, Panama for the WBA Continental super welterweight title on December 17, in a scheduled 10 round bout. Both boxers came in at around the welterweight limit, with Mosley slightly heavier and López fighting for the first time in 13 months. López was knocked down in the 2nd round following a left hook and a further three times in the last round, which put an end to the fight. Mosley improved his ledger to 49 victories, with 41 of those victories coming inside the distance. At the time of stoppage, the three judges' had the fight 87-83, 86-84, 88-83 in favour of Mosley.