In 1994, his paper "Molecular Computation of Solutions To Combinatorial Problems" described the experimental use of DNA as a computational system. In it, he solved a seven-node instance of the Hamiltonian Graph problem, an NP-complete problem similar to the travelling salesman problem. While the solution to a seven-node instance is trivial, this paper is the first known instance of the successful use of DNA to compute an algorithm. DNA computing has been shown to have potential as a means to solve several other large-scale combinatorial search problems. Adleman is widely referred to as the Father of DNA Computing.