The series is based on Domo, a Japanese mascot character who had previously appeared in many short commercials for the NHK channel. It follows him and his friends—Mr. Usaji the rabbit, Tashanna the weasel, and two bats named Maya and Mario—on simple adventures devoid of dialogue. Each episode is about two minutes long and is entirely animated in stop motion. Nickelodeon made creative changes to the existing world of Domo for "Domo TV", such as new locations and an updated rock-inspired theme song.