Manzano has received awards from the Association of Hispanic Arts, the Congressional Hispanic Caucus, the Committee for Hispanic Children and Families, the Hispanic Heritage Award for Education in 2003, and the "Groundbreaking Latina Lifetime Achievement" award from the National Association of Latina Leaders in 2005. She received a Doctor of Fine Arts degree from University of Notre Dame in 2005. As in Ms. Manzano's case, a D.F.A. is typically an honorary degree conferred to someone who has made a significant contribution to society in the arts. The Dream Big Initiative of the Bronx Children's Museum honored Manzano in 2014.