Vivian Bearing (Emma Thompson) is a professor of English literature known for her intense knowledge of metaphysical poetry, especially the Holy Sonnets of John Donne. Her life takes a turn when she is diagnosed with metastatic Stage IV ovarian cancer. Oncologist Harvey Kelekian (Christopher Lloyd) prescribes various chemotherapy treatments to treat her disease, and as she suffers through the various side-effects (such as fever, chills, vomiting, and abdominal pain), she attempts to put everything in perspective. The story periodically flashes back to previous moments in her life, including her childhood, her graduate school studies, and her career prior to her diagnosis. During the course of the film, she continually breaks the fourth wall by looking into the camera and expressing her feelings.