In a warm-up match against Durham before the 2010 season started, Keedy broke his collar bone. The injury left him unable to play for several months. In Keedy's absence, Lancashire's young spinners, Stephen Parry and Simon Kerrigan, were given opportunities in the first team. Kerrigan was chosen ahead of Parry in the four-day team and cemented his place in the side. When Keedy returned from injury he and Kerrigan sometimes bowled together in the County Championship. Their partnership began with them competing to out perform each other. After a discussion the pair decided they would be more effective if they worked together to build pressure while bowling. Keedy finished the season with 31 first-class wickets at an average of 22.19.