After passing over a Union Pacific rail yard, US 45 becomes concurrent with only US 12 in Melrose Park as US 20 breaks off at Lake Street there. US 12 and US 45 remain concurrent on Mannheim Road, passing Interstate 294 again without an interchange, but, after passing Illinois Route 19 (Irving Park Road), has a full interchange with Interstate 190, which leads directly to O'Hare International Airport or Interstate 90 East (into Chicago). This area between IL19 and IL72 once ran straight though but was realigned to the east in 1960 for the construction of O'Hare's 4R/22L runway.