Andreas died poor in Rome in 1502. Whether he had any children is uncertain. It is possible that a Constantine Palaiologos, employed in the Papal Guard and dead in 1508 was his son. According to Russian sources, he might also have had a daughter, Maria Palaiologina, who married a Russian prince. A Fernando Palaiologos, referred to as the "son of the Despot of the Morea" by Ludovico Sforza, Duke of Milan, in 1499 might also have been a son of Andreas. Andreas's brother Manuel died in Constantinople at some point during the reign of Mehmed II's son and successor Bayezid II (1481–1512). Manuel had two sons; John Palaiologos, who died young, and Andreas, probably named after Manuel's brother. Manuel's son Andreas converted to Islam and might have served as an Ottoman court official. He is last attested in the reign of Suleiman the Magnificent (1520–1566) and is not believed to have had children of his own. Thus, the male line of the imperial branch of the House of Palaiologos probably went extinct at some point in the early 16th century.