Mindelense had the first two matches won in the 2017–18 season, their last win was over Académica Mindelo on December 17 and Mindelense was first. Mindelense is currently second place with 7 points, their first position was grabbed by Batuque, they made a draw with Ribeira Bote on January 6 without any goals scored. Their next match was a goal draw with SC Farense de Fonte Filipe and was third with 8 points, shared with Derby, Mindelense scored four goals at the round, the lowest with their last with five goals at that round last season. Another win was made over Salamansa on January 27 and was still third with 11 points and 5 goals scored alongside Académica Mindelo, the fourth most. Also when MIndelense won, so did Derby and equals the points with the clubs. Mindelense defeated Batuque on February 3 and became second with fewer goals than Derby. It was followed by a two-goal draw with Derby, then Mindelense alongside Derby underwent a three match winning streak defeating Castilho, Académica and Ribeira Bote. At the 9th round, they had 12 goals scored, sharing with Batuque. Mindelense was still second with 14 goals scored, second in the region shared with Castilho. The winning chain with Derby was broken as Mindelense made a goal draw with Farense Fonte Filipe and was second with two points below Derby. Their goal totals were 15, third ahead of Académica and Castilho's 14. Mindelense made another win on March 18, this one over Salamansa and the club had ten goals less than Derby's. The Mindelo Derby was their final match of the season and featured Derby, Mindelense defeated that club 1–2 and became regional champions and conquered their 50th regional title and headed to the national championships on April 7 and be in Group A. Mindelense scored 20 goals, third behind Batuque's and Derby's. Also Mindelense now has its 28 match unbeaten streak at the regionals.