The song is built around many samples: a drum break from organist George Semper's cover version of Lee Dorsey's "Get Out of My Life, Woman"; a sample of James Brown grunting from the opening of his song "Say It Loud – I'm Black and I'm Proud"; a sample of the line "insane in the brain" from Cypress Hill's own song "Hole in the Head"; the opening keyboard from Sly and the Family Stone's "Life", a sample of the line "I think I'm going crazy" from the Youngbloods' "All Over the World (La La)" which concludes the track and the most prominent sample throughout the song, a repeating sample of, in which DJ Muggs initially claimed, a pitched blues guitar, although shortly after, he changed his story and claimed that that sound is a horn, as explained below: