Changampuzha started a career as a clerk in Port trust. He could not continue there due to health and personal reasons. He took up another assignment at a Printing Press (Mangalodayam) at Thrissur. He got married and became a father of four children, among which his younger son died before he turned one. Later, he started suffering from tuberculosis and became bed ridden. Finally in 1948, on the rainy day of 17 June at half past 3 pm, he died at the age of thirty six and nine months. His body was cremated in the compound of his house at Edappally. An appropriate monument has been erected there, which is visited by the lovers of Malayalam language. He is now survived by his younger daughter Lalitha. His wife outlived him for 54 years, finally dying in 2002. His elder son Sreekumar died in a road accident in 2004. His elder daughter Ajitha committed suicide in the late 1980s with her whole family.