However, Lordgenome's plans go awry when Team Dai-Gurren is formed, and he is eventually forced to fight Gurren Lagann in Lazengann to put an end to the human resistance. Lordgenome is fatally injured by Simon as a result, cryptically prophesying the Anti-Spirals' return before he falls off of Tepellin. Seven years later Lordgenome's brain is recovered by Rossiu, and regenerated into a head that serves as a "bio-computer" to provide the group access to all of his knowledge. He eventually regains his self-awareness and his personality from before being driven mad, and helps in the fight against the Anti-Spirals, even completely regenerating and sacrificing himself during the final battle so Team Dai-Gurren can win.