She then paired with Mohanlal in "Rasathanthram" (2006). She played as a girl pretending to be a boy in the first half of the film. The film went on to become a commercial success. Her next film with Dileep – "Vinodayathra", which again was directed by Sathyan Anthikkad. She was next featured opposite Mammootty in the critically acclaimed film "Ore Kadal". The film was showcased in film festivals and won awards. Her performance as an innocent middle-class woman won praise from audiences. Media quoted her as, "Matching step with the megastar in this histrionic race is Meera Jasmine, who amazes you with a stunning delineation of her difficult role" . Her next film was "Calcutta News" with Dileep. Blessy, who introduced her to film field, was the director of "Calcutta News". In "Innathe Chintha Vishayam" (2008), she collaborated with Sathyan Anthikkad for his fourth consecutive film, again opposite Mohanlal, but failed to succeed. Her next films "Minnaminnikoottam" with Kamal and "Rathri Mazha" with Lenin Rajendran, which released after a long post-production delay, were box office failures.