Breckenridge has had numerous voice roles in the animated television series "Family Guy". During an interview with "FHM", she stated: "When I first went for "Family Guy", I auditioned for a guest voice. I don't know why, but Seth MacFarlane really likes the sound of my voice. I'll never understand that. He just liked me and they call me back all the time to do different things." Breckenridge often does celebrity impressions in the series, such as Sarah Jessica Parker and Renée Zellweger. She also had roles in MacFarlane's web series "Cavalcade of Cartoon Comedy". Breckenridge also guest starred in the episode "With Friends Like Steve's" of "American Dad!", also created by MacFarlane.