The airport was leased by the United States Army in 1942. Between 1942 and 1944, the U.S. War Department acquired 4,248.12 acres in fee from various private parties, 6.54 acres of public domain land by transfer, 282.61 acres by lease from the County of Riverside, a 1.98-acre easement, and a 0.63-acre permit. The Army encroached on another 20.18 acres, increasing the total acquisition for Blythe Army Air Field to 4,560.06 acres. Over 650 buildings and other types of military facilities and improvements were constructed at this airfield, including hangars, office buildings, barracks, warehouses, runways and taxiways, water and sewer systems, a hospital, and fuel and ordnance storage. The base was advertised as the "World's Healthiest Air Base".