As of March 2006, there appear to have been two issues. There was the issue of the trial protocol of giving the drug to six participants within a short time. While the MHRA had approved a two-hour protocol, the drug was administered to all participants within just twenty minutes, based on the statement of a study participant. Neither the companies involved nor the authorities have commented on that point. Another issue was whether the company should have anticipated that the drug would provoke this reaction in humans. The comments on the company webpage and in the patent application indicated that the company knew that this type of drug could cause a severe cytokine release syndrome. An immunologist contacted by "New Scientist" and who wished to be anonymous has commented that "You don’t need to be a rocket scientist to work out what will happen if you non-specifically activate every T cell in the body."