Wheeler was one of the first women to campaign for women's rights at public meetings in England. She sometimes spoke at the South Place Chapel, "a radical gathering-place" then under the leadership of the Reverend William Johnson Fox and now better known as Conway Hall. Unitarians, like Quakers, supported female equality, and this chapel, situated on Finsbury Square in central London, gave her the pulpit to speak on "The Rights of Women". In this address of 1829, Wheeler forensically refuted arguments for male superiority and encouraged women to work together to create an organisation "to obtain... the removal of the disabilities of women and the introduction of a national system of equal education for the Infants of both sexes."