Villefranche's bay is notable for reaching a significant depth only a short distance from shore. As a result, it has become an important port over the years. Since World War I, the United States Navy has called on a regular basis, making Villefranche the home port of the U.S. 6th Fleet from 1948 to February 1966, when French President Charles de Gaulle withdrew France from NATO and required U.S. forces to leave. Just prior to 1966, the flagship of the Commander Sixth Fleet rotated between and . Since the 1980s Villefranche has been used by cruise ships. It is the most visited cruise ship port of call in France.