Annihilus has at various times been the ruler of the Negative Zone, controlling its inhabitants via his powerful Cosmic Control Rod. He first encountered the Fantastic Four after Reed Richards discovered how to travel to the Negative Zone from Earth. Over the years he clashed with the Fantastic Four on many occasions, often with the group foiling his plans to invade Earth. He is often the partner of Blastaar, who started out as a rival to Annihilus' rule of the Negative Zone before becoming allies.