In 1865, Nation met Charles Gloyd, a young physician who had fought for the Union, who was a severe alcoholic. Gloyd taught school near the Moores' farm while deciding where to establish his medical practice. He eventually settled on Holden, Missouri, and asked Nation to marry him. Nation's parents objected to the union because they believed he was addicted to alcohol, but the marriage proceeded. They were married on 21 November 1867, and separated shortly before the birth of their daughter, Charlien, on 27 September 1868. Gloyd died in 1869 of alcoholism.