Her most famous character was dowdy spinster Gladys Ormphby, clad in drab brown with her bun hairdo covered by a visible hairnet knotted in the middle of her forehead. Buzzi first used this look when she played Agnes Gooch in a school production of "Auntie Mame". In most sketches, she used her purse as a weapon, with which she would flail away vigorously at anyone who incurred her wrath. She most often was the unwilling object of the advances of Arte Johnson's "dirty old man" character Tyrone F. Horneigh. In a typical exchange, Tyrone accosts Gladys and asks, "Do you believe in the hereafter?" "Of course I do!" Gladys retorts defensively. Delighted, Tyrone shoots back: "Then you know what I'm "here" after!" NBC collectively called these two characters "The Nitwits" when they went to animation in the mid-1970s as part of the series "Baggy Pants and the Nitwits". Buzzi and Johnson both voiced their respective roles in the cartoon.