The highway's eastern terminus is in Virginia Beach, Virginia, where it is known as Pacific Avenue, in the city's Oceanfront resort district at the intersection of 5th Street and Winston-Salem Avenue. Its original western terminus was in Springfield, Missouri; it was then extended to Los Angeles, California; but in 1964 it was truncated to end southwest of Brenda, Arizona at an interchange with Interstate 10 (I-10) after the US 60 highway designation was removed from California. Some US 60 signs can be seen at this interchange about southwest of Brenda. I-10 replaced US 60 from Beaumont, California to Arizona, and California State Route 60 (SR 60) replaced US 60 from Los Angeles to Beaumont.