Lionville is bisected by two major local highways, PA 100 and PA 113. The area contains residential neighborhoods, hotels, restaurants, and other businesses. The original name of the village was Welsh Pool, but to honor the local Red Lion Inn the name was changed to Lionville, since a borough of Red Lion, Pennsylvania, already existed. The area of Lionville along Village Avenue is a protected historic district. The Friends Meeting House was used as a hospital by the Continental Army during the American Revolutionary War.