The ship was assigned to the 5th Cruiser Squadron from 1906 to 1908 and was then transferred to the 1st Cruiser Squadron of the Channel Fleet. When the Royal Navy's cruiser squadrons were reorganized in 1909, "Duke of Edinburgh" rejoined the 5th Cruiser Squadron of the Atlantic Fleet. On 13 August 1910 "Duke of Edinburgh" ran aground on Atherfield Ledge, Isle of Wight. She was successfully refloated, but in the resulting Court-martial to investigate the incident, the ship's Captain and Navigating Officer were severely reprimanded and the latter dismissed from the ship. She helped to rescue the survivors of the SS "Delhi" which ran aground off the coast of Morocco in December 1911. From 1913 to 1914 she served with the 1st Cruiser Squadron of the Mediterranean Fleet.