Jefferson City is located on the northern edge of the Ozark Plateau on the southern side of the Missouri River in a region known as Mid-Missouri, that is roughly mid-way between the state's two large urban areas of Kansas City and St. Louis. It is 29 miles south of Columbia, Missouri, and sits at the western edge of the Missouri Rhineland, one of the major wine-producing regions of the Midwest. The city is dominated by the domed Capitol, which rises from a bluff overlooking the Missouri River to the north; Lewis and Clark passed the bluff on their historic expedition upriver before Europeans established any settlement there.