The 1921 Florida Gators football team (variously "Florida", "Gators", or "UF") represented the University of Florida in the 1921 college football season. It marked the Florida Gators' 15th overall season, and its 9th and final as a member of the Southern Intercollegiate Athletic Association (SIAA). The Gators played their home games at Fleming Field in Gainesville, Florida. It was head coach William Kline's second season leading the Gators' football team. They finished the season with a record of 6 wins, 3 losses, and 2 ties (6–3–2 overall, 4–1–2 in the SIAA), finishing sixth in conference play.