On 4 May 1883, an accident occurred when the branch service from Stranraer via the Dumfries, Lochmaben and Lockerbie Railway passed a signal and entered the station at 23:25. It collided at low speed, with a goods train already on the northbound line. This collision, though minor, forced carriages from the goods train onto the southbound line and into the path of the speeding Glasgow Express which smashed into the wreckage and derailed onto the station platform. Seven people were killed, including the driver and fireman of the express. The guard from the express ran down the line to warn another approaching train of the accident and prevented a further collision. There were 300 injuries. The driver of the first train, the Lockerbie station master and the local inspection regime were all criticised for their actions in the subsequent report on the crash.