US 60, along with US 51 and US 62, crosses into the state of Kentucky from Cairo, Illinois. US 60 splits off from this concurrency at Wickliffe, and heads northeast towards Paducah. US 60 has an interchange with Interstate 24 and enters the city along with Business Loop 24. US 60 joins US 62 once again, and the routes head out of Paducah. US 60 splits off to the northeast and crosses the Tennessee River, while US 62 heads southeast and serves as the western terminus of US 68.