Arquette made her feature film debut as Kristen Parker in "" (1987). Her other notable films include "True Romance" (1993), "Ed Wood" (1994), "Flirting with Disaster" (1996), "Lost Highway" (1997), "The Hi-Lo Country" (1998), "Bringing Out the Dead" (1999), "Stigmata" (1999), "Holes" (2003), "Fast Food Nation" (2006), "The Wannabe" (2015), and "Toy Story 4" (2019). For playing a single mother in the coming-of-age film "Boyhood" (2014), which was filmed from 2002 until 2014, Arquette won the Academy Award for Best Supporting Actress.