After an unproductive start to the 2015 season, in which the Dolphins were 1-3 and Wake had one tackle, head coach Joe Philbin was fired and replaced with tight ends coach Dan Campbell. Wake returned to his dominant form, recording six sacks and four forced fumbles in a two-week span, which were both wins against the Titans and Texans. In a game against the Patriots, Wake notched his seventh sack, which put him in second place on the NFL leaderboard, but he was also injured and carried off the field on a later play. On October 30, 2015, NFL Insider Ian Rapoport reported, due to an Achilles injury, that Wake was out for the rest of the 2015 NFL season.