From there, US 60 follows the Ohio River, traveling through the city of Smithland, and junctions US 641 at Marion. US 60 continues northeast to Morganfield, and then to Henderson, where it joins alternate US 41. The two routes head to the other side of Henderson, where they have an interchange with US 41. Currently, Kentucky's segment of Interstate 69 ends south of Henderson, but once connected with the mainline in Indiana, the interstate will be concurrent with US 41 and share the interchange with US 60. From there, US 60 heads east towards the city of Owensboro.