Holt endorsed Barack Obama in the 2008 presidential election, stating, "I used to have a lot of respect for McCain, but he realized after the dirty defeat that he suffered at the hands of George W. Bush in the South Carolina primary in the (2000) election that he can only get elected if he plays the Karl Rove tactic b.s. He's doing it. It's just one debunked lie after the other. He's the kind of guy who will tell you the sky is red, you look up and it's blue, and he won't admit he's wrong. He's playing dirty politics. Palin is just terrifying, the thought of this lady being a heart attack away from having the nuclear codes. She's crazy and she's dumb."