In 1894, Upton was elected as the NAWSA's treasurer. In addition, Upton served as president of the Ohio association of the national association, from 1899-1908 and 1911–1920. Upton helped relocate the national headquarters for the NAWSA to her home in Warren, Ohio, in 1903. According to the Tribune Chronicle, "it was only supposed to be a temporary move, but it lasted six years. Susan B. Anthony, noted leader of the women's movement, visited Warren many times, including a 1904 trip to attend a national women's rights meeting here."