After a relatively uneventful freshman season, Brees was given his first start during his sophomore year by Boilermakers head coach Joe Tiller and became an integral part of Tiller and Jim Chaney's unorthodox "basketball on grass" spread offense, serving as offensive captain during his junior and senior years. He had the option to make himself available for the 2000 NFL Draft but chose to return for his senior year to complete his studies. In 2000, he led the Boilermakers to memorable last-minute upsets against top-ranked Ohio State and Michigan en route to the Boilermakers' first Big Ten championship (shared with Michigan and Northwestern) since 1967. The Ohio State game was replayed on ESPN Classic and is widely remembered for Brees's four interceptions and 64-yard touchdown pass to Seth Morales with 1:55 remaining to seal a vital 31–27 win, prompting commentator Brent Musburger to exclaim "Holy Toledo!" and a post-game field rush. Due to head-to-head victories over Michigan and Northwestern, Purdue won the invitation to the 2001 Rose Bowl, Purdue's first appearance there since 1967, where Purdue lost by ten points to the Washington Huskies.