Education played a major role in the socio-economic transformation of the archipelago. The oldest universities, colleges, and vocational schools and the first modern public education system in Asia were all created during the Spanish colonial period, and by the time Spain was replaced by the United States as the colonial power, Filipinos were among the most educated subjects in all of Asia. The Jesuits founded the Colegio de Manila in 1590, which later became the Universidad de San Ignacio, a royal and pontifical university. They also founded the Colegio de San Ildefonso on August 1, 1595. After the expulsion of the Society of Jesus in 1768, the management of the Jesuit schools passed to other parties. On April 28, 1611, through the initiative of Bishop Miguel de Benavides, the University of Santo Tomas was founded in Manila. The Jesuits also founded the Colegio de San José (1601) and took over the Escuela Municipal, later to be called the Ateneo de Manila University (1859). All institutions offered courses included not only religious topics but also science subjects such as physics, chemistry, natural history and mathematics. The University of Santo Tomás, for example, started by teaching theology, philosophy and humanities and during the 18th century, the Faculty of Jurisprudence and Canonical Law, together with the schools of medicine and pharmacy were opened.