Pavlyuchenkova started the grass-court season with opening round losses to Jeļena Ostapenko and Madison Brengle in Birmingham and Eastbourne respectively. At the Wimbledon Championships, Pavlyuchenkova was the 21st seed and she moved past Hsieh Su-wei and Yulia Putintseva to reach the third round where she upset Timea Bacsinszky to advance to the second week of a Grand Slam tournament for the first time since the 2011 US Open. In the fourth round, she defeated Coco Vandeweghe for a place in her third Grand Slam quarterfinal, also her first since the 2011 US Open. There, she faced Serena Williams and was defeated by the defending champion in straight sets. Following the conclusion of Wimbledon, Pavlyuchenkova re-entered the top 20 rankings for the first time in more than four years at No. 19.