A vigorous and outspoken liberal, he served in the Senate until his death of a cerebral hemorrhage at the age of 47. Diagnosed with testicular cancer in 1958 that became terminal by 1960—but was kept from the public—Neuberger remained at his N.W. Portland home in early 1960, reportedly battling the flu. Though still publicly seeking re-election, he told his campaign chair, attorney Jack Beatty, "Remember, there's always another Neuberger," referring to his wife. The comment, combined with Neuberger's reluctance to meet in public and weak voice on the phone, led Beatty to believe that Neuberger's condition was grave, a suspicion confirmed by the Senator's physician shortly before Neuberger died at Good Samaritan Hospital on March 9, 1960. A delegation of senators, led by Democratic Majority Leader Lyndon Johnson, attended Neuberger's funeral. He was buried at Beth Israel Cemetery in Portland.