NY 277 crosses north past a junction with Reserve Road (CR 366) and East and West Road (CR 363) before passing the Houghton College at West Seneca. NY 277 then crosses over Cazenovia Creek and enters the commercial hamlet of Ebenezer, where it intersects with Seneca Street (CR 215). Continuing north through the town of West Seneca, passing east of Centennial Park and entering a junction with NY 16 (Center Road). Passing Mount Hope Cemetery, the route goes north several blocks into an interchange with NY 400 (the Aurora Expressway) before crossing over tracks owned by Norfolk Southern.