In January 2007, Feldman was named the first director of the A. Alfred Taubman Medical Research Institute, which was founded by philanthropist A. Alfred Taubman to empower medical scientists to expand the boundaries of discovery, to develop new therapies for disease, and to alleviate human suffering. Under her leadership, the Taubman Institute funded senior-level physician scientists in a diverse spectrum of diseases: adult and childhood cancer, ALS, diabetes, cardiovascular disease, and hearing loss. She also established an Emerging Scholars program to support promising early-career physician scientists. She remained director until 2017.