A.I.M. employed Batroc the Leaper to recover an explosive compound called Inferno 42 and dispatched a chemical android against Nick Fury and Captain America. A.I.M. also dispatched their special agent, the Cyborg, against Captain America. A.I.M. was involved in a skirmish with the Maggia and its "Big M". A.I.M. has also captured Iron Man in an attempt to analyze and replicate his armor. MODOK and A.I.M. were responsible for transforming Betty Ross briefly into the gamma-irradiated bird-woman called the Harpy. A.I.M. dispatched their special agent the Destructor to capture Ms. Marvel.