The game begins in the Arizona Territory in 1876 with Jericho attempting to rob a Darkwatch train that is transporting the captured Lazarus Malkoth to the Darkwatch Citadel, a frequently mentioned and often visited location in the game. His actions inadvertently release Lazarus into the West. In a seeming bit of mercy, Lazarus bites Jericho and gives him the curse of the vampire, causing him to slowly turn into one. The game continues with the introduction of Darkwatch agent Cassidy Sharp as well as the appearance of Shadow, Jericho's undead horse whom he fed on and turned in a frenzy after being bitten by Lazarus.