NY 226 begins at an intersection with the off-ramps from interchange 40 on the Southern Tier Expressway (I-86 / NY 17) in the town of Bath. An eastward continuation of County Route 12 (CR 12), the two routes are concurrent for a short distance, crossing under the expressway as West Lamoka Avenue. NY 226 and CR 12 cross Mud Creek and enter the village of Savona, where CR 12 terminates, and NY 226 continues eastward as a four-lane arterial. After crossing the village line, NY 226 intersects with NY 415 (Coopers–Bath Road). Changing cardinal directions, NY 226 proceeds east as a two-lane residential street, East Lamoka Avenue. Running along the northern end of the village, NY 226 proceeds east along Mud Creek, before turning northeast, becoming a two-lane rural roadway.