On October 5, 2008, during the week 5 contest against the Arizona Cardinals, Edwards suffered a concussion as a result of a hard hit by Adrian Wilson on the third play of the game and did not return for the rest of the game. However, Edwards returned in the following game in week 7 against the San Diego Chargers and completed 25 of 30 passes in a 23–14 win. He was selected as the FedEx Air Player of the Week for his performance.