The Station Master's house was built in 1900, after which there were no significant changes until the 1960s. The GWR was nationalised on 1 January 1948, becoming part of the Western Region of British Railways, but apart from new signs this had little effect at Twyford until the 1960s. In 1961 the trackwork was simplified and the two signal boxes were decommissioned and replaced by a single one in the vee between the up relief and branch lines. This lasted only until 1972, when all signalling control was transferred to Reading. The goods yard and cattle dock closed in 1965 and were cleared to provide the present car parks. In 1975 the road bridge was reconstructed and platforms 1 and 2 altered to reduce the curve through the station and make the main lines suitable for High Speed Trains.