In 2010, she was cast as Sheriff Jody Mills on the CW's show "Supernatural". She first appeared in Season 5; episode "Dead Men Don't Wear Plaid", with her character appearing in every season since as a guest star. In 2018, Season 13; episode “Wayward Sisters“ was used as a backdoor pilot for a possible spin-off series of the same name, intended to feature Rhodes and fellow actresses Briana Buckmaster and Kathryn Newton as the main characters. The new series ultimately did not move forward.