Santos-Febres' first novel was "Sirena Selena vestida de pena" (Spain: Grijalbo Mondadori, 2000) about a teenaged drag queen who works in the streets and sings boleros. A finalist for the 2001 Rómulo Gallego’s Prize for the Novel, it won the PEN Club of Puerto Rico’s prize for Best Novel. Random House Mondadori published her second novel, "Cualquier miércoles soy tuya", in 2002. Her third novel, "Nuestra Señora de las noche" (Rayo/HarperCollins, 2008), was a finalist for the Premio Primavera Literary Award and won Puerto Rico’s 2007 Premio Nacional de Literatura. Her other novels include "Nuestra Señora de la Noche (Our Lady of the Night)" and "La amante de Gardel" (2015).