The district's very fertile land produces wheat, onion, sugarcane, cotton, chillies, and mangoes. Irrigation and farming was revitalised after the Jamrao Canal was built in the 1900s. Afterwards, the city was able to produce and cycle crops to supply mainly grain, cotton products like fabrics, and sugar from the sugarcane cultivation. For a certain period in history, Mirpurkhas enjoyed being the best cotton producer in the country and much of the income of the town came from cotton farming in its heyday.