The long-running opposition to the Jesuit missions and presence terminated in the Pericúe revolt of 1734, in which several Jesuits and their followers and Spanish sailors were killed by the Pericú and Guaycura, especially the Uchití band. Meanwhile the Guaycura were being devastated by introduced European diseases such as measles and smallpox. In 1748, after many years of frustration, the Jesuits decided to concentrate the southern bands of the Guaycura into a single settlement at Misión Todos Santos. There, the Jesuits forcibly detained the Guaycura children at the mission and their parents and relatives "for love of the children remained pacified."