The game opens with a conversation between Garcian Smith and Christopher Mills about a new job for the killer7. The assassins battle their way to the top of a building which has become infested with Heaven Smiles. Harman confronts the source of the Smiles, an angel-like figure, but she is merely Kun Lan's puppet. Harman and Kun Lan discuss the current state of the world before the mission ends. In the subsequent missions, the killer7 target a number of individuals on behalf of the US government or for personal reasons. They kill Andrei Ulmeyda (Cam Clarke), a Texan postal worker who established a successful company based on the Yakumo, when he becomes infected with the Heaven Smile virus. Dan Smith confronts Curtis Blackburn (Alastair Duncan), his former mentor and murderer, when Mills informs the group that Blackburn is running an organ smuggling business that targets young girls. Their penultimate mission pits them against the "Handsome Men", a group of sentai rangers who assassinate a US politician.