In 2002, Grier joined the cast of the improv-based ABC sitcom and Bonnie Hunt vehicle "Life with Bonnie" which ran only two seasons. During this time, he continued to appear in comedy films but also returned to drama in the films "Baadasssss!" (2003) and "The Woodsman" (2004). He starred in his own Comedy Central stand-up special "The Book of David: The Cult Figure's Manifesto". He is also a frequent guest on the Comedy Central show "Crank Yankers". Grier was the host of the NBC show "Thank God You're Here."