The church was destroyed in the Great Fire of 1666. The tower remained standing for a while, but this too was demolished to make way for the new church. The parish was combined with that of St Leonard Eastcheap in 1670 and rebuilding began in 1681. The 1686 accounts include an entry of £1 14s 0d "to wine and sweetmeats for treating the Lord Mayor at the opening of the Church", although work on the spire continued into the following year. The total cost of the church was £4,583.