In March 2012 de Niese appeared as Norina in "Don Pasquale" at the San Diego Opera. She performed that role again the following year at the Glyndebourne Festival Opera. In November 2013 she portrayed Poppaea in Handel's "Agrippina" at the Liceu. In 2014 she appeared as the title heroine in Francesco Cavalli's "La Calisto" at the Bavarian State Opera, sang Anne Trulove in "The Rake's Progress" at the Teatro Regio di Turino, and performed the title role in Handel's "Partenope" at the San Francisco Opera.