When Wilhelm on 15 August 1568 went back to Brabant to continue his war against the Spaniards, Anna decided on 20 October 1568 although pregnant again, to leave Dillenburg with her court (probably 43 people), to escape the antipathies of his mother and to create a new home in Cologne. Their two children, Anna and Maurits, had been taken by her mother-in-law to Braunfels due to the risk of disease. The next year, after a fierce battle with William's mother, she was able to bring her children back to him. Her daughter Emilia was born on 10 April 1569 in Cologne.