Pennsylvania Route 501 (PA 501) is a north–south state highway in south central Pennsylvania that runs for . Its southern terminus is at U.S. Route 222 (US 222) and PA 272 north of Lancaster, and its northern terminus is PA 895 southeast of Pine Grove. The route heads north from Lancaster and runs through suburban and rural areas in northern Lancaster County, passing through Lititz and crossing US 322 in Brickerville. PA 501 continues into Lebanon County and heads into the Lebanon Valley, where it passes through Schaefferstown and intersects US 422 in Myerstown. The route passes through western Berks County, where it has an interchange with Interstate 78 (I-78)/US 22 near the community of Bethel. PA 501 crosses Blue Mountain into Schuylkill County and continues to its northern terminus.