On 18 May 1925, "Whipple" and her division sailed for the United States, via Guam, Midway, and Pearl Harbor, and arrived at San Diego on 17 June. Five days later, the ship got underway for the United States East Coast; and she arrived at Norfolk on 17 July. She next operated off the U.S. East Coast from Maine to Florida and cruised to Guantanamo Bay for maneuvers with the Fleet. During this time, "Whipple" put ashore a landing force in Nicaragua to protect American lives and property threatened by the banditry and unrest. On four separate instances, in late 1926 and early 1927, a landing party from the destroyer served on shore, earning the ship the Second Nicaraguan Campaign Medal.