Until the present day several bio-mimetic compounds have been developed: Collman "et al." produced ruthenium porphyrins, furthermore of the bio-mimetic compounds published by the research teams of Rauchfuss, Darensbourg and Pickett (in Artero and Fontecave) who developed bio-mimetic compounds of the hydrogenase. More recently Manor and Rauchfuss presented a very interesting mimic compound based in the [NiFe hydrogenase with bidirectional properties, this compound has the characteristic that it carries two borane protected cyanide ligands at the iron atom. Some works about bio-mimetic compounds of hydrogenases are summarized in table 1.