On 15 August 1934, "Du Pont" returned to active commission. She left Charleston, South Carolina, 15 September, served as target vessel and plane guard in the Caribbean, then arrived at San Diego 9 November. Based there she served in training and tactical development with the fleet, cruising to Alaskan waters and Pearl Harbor on a problem during 29 April 1935 – 10 June 1935. She sailed from the west coast 27 April 1936 for the annual fleet problem held that year in the Canal Zone, then transited the Panama Canal, and arrived at Jacksonville, Florida, 7 June for Naval Reserve training duty along the east coast. Arriving at Philadelphia Navy Yard 29 September 1936, "Du Pont" was placed out of commission 14 January 1937.