Cherokee High School has been notable for its sports teams through the years. Bud Mills (1950-1973, 1989), is a member of the Alabama Sports Hall of Fame. Mills had a career record of 152-81-4 during 25 years as a head coach. Garner Ezell (1983–85) led the Indians to Area Championships twice in three years, advancing to the Semi-finals in the 1984 season and the Quarter-finals in 1985. In 1985, the Indians recorded their first 12 win season while leading the area in most stats.