Several major federal highways intersect at Newport. Interstate 40 passes through the city's southern section about north of the North Carolina border. U.S. Route 321 runs perpendicular to I-40, approaching Newport from Cosby to the south. U.S. Route 411 merges with U.S. Route 70 in Carson Springs, and the merged road enters Newport from the west, intersecting US-321 in downtown Newport. US-70 continues east to Del Rio, Tennessee, and Hot Springs, North Carolina, while US-321 turns north and crosses the Pigeon and French Broad en route to Greeneville and northeastern Tennessee.