US 50 heads northeast, locally known as Wooster Pike. The route heads through commercial properties as a two-lane undivided highway, before leaves Fairfax and enters Mariemont. In Mariemont US 50 becomes a two-lane divided highway passing through residential properties. The roadway becomes a four-lane divided highway in the business area of Mariemont. After leaving the business area of Mariemont the route becomes a four-lane undivided highway, passing through commercial properties. The route becomes a two-lane highway with a center turn lane, at an intersection with Newtown Road. The road curves northeast, passing north of the Kroger Hills State Reserve and passing under the Ohio to Erie Trail bike trail, also known as Ohio Bicycle Route 1. The highway enters Terrace Park, having an intersection with SR 126, this intersection is also the western terminus of SR 28. Both US 50 and SR 28 cross over the Little Miami River and enters the City of Milford. The route curves southeast, before turning northeast, passing through the downtown area of Milford. North of downtown the roadway curves east, passing through residential properties, with some commercial properties.