Gwen is recruited by Spider-UK to team up with other Spider-Totems across the multiverse, and next appears on Earth-616 with Old Man Spider-Man of Earth-4 and Spider-Man of Earth-70105 (who in that reality is Bruce Banner) to rescue Kaine, who was under attack by the Inheritors. Marvel-616 Peter is hesitant to put Gwen in action and she is told by the others of how he failed to save her in his world. However he does recruit her for a mission and they both agree to look out for each other. Gwen is sent to recruit an alternate version of Peter Parker who is driven insane after he failed to save the Gwen Stacy in his dimension, killed the Green Goblin, and became the Hobgoblin. She tells him that he can become the man he once was if he joins them, but they are attacked by the Inheritors. Hobgoblin sacrifices himself to save Gwen.