In 2005, Gil was given a VJ stint for ABS-CBN's music channel subsidiary, MYX until she left MYX in January 2016. She was also picked to host the now-defunct talk show MRS on ABS-CBN and morning show Breakfast on Studio 23. She later would join the cast of the weekly variety show "ASAP Mania". In 2006, she was joined by Toni Gonzaga, Bianca Gonzalez and Sam Milby as a host for the first season of "Pinoy Dream Academy", a singing reality show from Endemol. In 2007, she became part of an anime-inspired fantasy series "Rounin" and as an extended cast for the drama series "Pangarap na Bituin". In 2008, she was again chosen to be the host for the season 2 of Pinoy Dream Academy with Toni Gonzaga and Billy Crawford. In 2009, she appeared in "Pieta", an afternoon teleserye with Ryan Agoncillo, and also appeared in the teleserye "Florinda" with Maricel Soriano. Nikki Gil is one of the mainstay on ABS-CBN with ASAP XV. In 2010, she started hosting E-Live along with Luis Manzano and Ogie Diaz. She also did a fair share of hosting occasionally on "Showtime" replacing Anne Curtis.