U.S. Route 6, also known as the Mid-Cape Highway on Cape Cod, passes through the town to the north of Otis Air National Guard Base as a four-lane divided freeway. There are three exits off this route within town. Massachusetts Route 6A passes through town to the north of Route 6, and is the town's main local road. The northern terminus of Massachusetts Route 130 is near the intersection of Routes 6 and 6A within town. The road passes along the eastern side of Otis on its way towards Mashpee.