On 1 Jan, 1776, the 3rd Regiment was redesignated as the 2d Continental Regiment and assigned to Sullivan's Brigade. On 27 April 1776, the regiment was assigned to the Canadian Department and was sent to Canada via New York City and then Albany via the Hudson River under Major General John Sullivan during the Invasion of Canada campaign. As the regiment arrived in Canada they suffered through a smallpox epidemic. They made it as far as Montreal where they were from June 12–17 and are shown there on Major Alexander Scammell's Return of the Continental Forces in Canada. The return of Reeds Regiment, dated 21 April 1776, showed 518 officers, staff, and rank and file, and then on General Horatio Gates' return, dated 24 August 1775, there were only 409 men in the regiment, an unfortunately typical loss for regiments in the Canadian Department. The 3rd Regiment returned to Fort Ticonderoga on 16 July 1776, and were there until November 1776.