This game was the last to be released in the "Space Quest" series. Having defeated the diabolical pukoid mutants in "Space Quest V", Captain Roger Wilco triumphantly returns to StarCon headquarters - only to be court-martialed due to breaking StarCon regulations while saving the galaxy. The game's subtitle comes from the final portion, in which Roger has to undergo miniaturization and enter the body of a shipmate and romantic interest, a spoof of the 1987 movie "Innerspace". (This segment also provided the game's original subtitle, "Where in Corpsman Santiago is Roger Wilco?", which was not used due to legal threats from the makers of the "Carmen Sandiego" products.) The romantic interest provides a dilemma for Roger (unprecedented in the series) since she is a friend and someone other than the woman who bore Roger a son, according to the narrative in "Space Quest IV".