In the 2011–12 CONCACAF Champions League, Santos defeated the Seattle Sounders FC in the quarter-finals and Toronto FC in the semi-finals. In the final, the club lost to Rayados of Monterrey. In the 2012 Clausura, Santos Laguna finished in first place for the second time in its history. In the quarter-finals, the club won 6–4 on aggregate. The first game of the semi-finals, against the UANL Tigres at the Estadio Universitario, ended in a 1–1 draw and Santos won the second game to advance to the final. After playing Monterrey to a 1–1 draw at Estadio Tecnologico, Santos Laguna won the second game 2–1 with goals by Daniel Ludueña and Oribe Peralta for the club's fourth title.