Brinegar was cast in more than 100 Western films produced between 1946 and 1994, often specializing in playing "feisty, grizzled cowboy sidekicks". On television, from 1956 to 1958, he played James H. "Dog" Kelley, the mayor of Dodge City, Kansas, in the ABC/Desilu series "The Life and Legend of Wyatt Earp" starring Hugh O'Brian. Brinegar appears in that series 33 times as Kelley and in one other episode in another role. He also portrays Ludwig, a bartender, in the 1959 episode "The Ringer" of "The Texan" starring Rory Calhoun. Brinegar, however, is best remembered as the cattle-drive cook George Washington Wishbone on the CBS series "Rawhide" (1959 - 1966). Earlier he had played a similar role, one as the character Tom Jefferson Jeffrey, in the 1958 movie "Cattle Empire" upon which "Rawhide" was based.