On 2 May 2010, Hargreaves made his Premier League return in the 93rd minute of United's penultimate game of the season against Sunderland. It was his first Premier League action since a 1–1 draw with Chelsea in September 2008, in which time he had missed 113 matches in 20 months. Despite this, Hargreaves missed the beginning of the 2010–11 season, having suffered another injury, for which he travelled to the United States to see a specialist. On 24 September, manager Sir Alex Ferguson announced that Hargreaves had returned to training. On 6 November 2010, he made his first start since September 2008 against Wolverhampton Wanderers, however it was short-lived after a hamstring injury forced his withdrawal for Bébé just five minutes into the match, which United went on to win 2–1.