La Bahía del Espiritu Santo, a mission-presidio complex, was established in 1722 on the southern bank of the San Antonio river. At first, the Karankawa were not antagonistic to the Spanish. But in 1723, a skirmish occurred between the Spanish and Karankawa, after which the Karankawa moved away from the mission and became hostile. By 1727, the Karankawa depredations forced the mission-presidio complex to move inland to the Guadalupe river, where they remained until 1749. The Karankawa successfully reduced Spanish claim to the Texas coast.