In the Clausura 2018 tournament, under the management of former goalkeeper Robert Dante Siboldi, Santos Laguna earned twenty-nine points, tied with América and Monterrey, but placed fourth due to goal difference. In the play-offs, the team faced defending champions Tigres UANL and lost 2-0 in the first leg of the quarterfinals. In the second leg, Santos Laguna played with ten players for most of the match as Jonathan Rodriguez was sent off in the 28th minute but managed to win 2-0 and advance to the semi-finals. At this stage, "Los Guerreros" defeated América 6-3 on aggregate and qualified for the finals against league leader Toluca. In the final first leg, played in Estadio Corona, both Djaniny Tavares and Julio Furch netted for Santos Laguna, helping the team defeat Toluca 2-1. In the second leg, Furch scored in the 10th minute but Toluca's Gabriel Hauche levelled in the final minutes of the match, which finished 1-1. Santos Laguna earned its sixth league title, whilst Djaniny Tavares finished the tournament as the top goal scorer, netting fourteen times, the eighth time a Santos Laguna player has achieved this feat.