Between 17 July and 12 September 1943, "Du Pont" made two voyages to the United Kingdom on convoy escort duty. On 25 September, she sailed from Norfolk for an antisubmarine patrol with a hunter-killer group centered on "Card". On 6 October she joined the screen for during exercises in Casco Bay and Long Island Sound. The group sailed from Norfolk 14 November to give close support to a Gibraltar-bound convoy. On the return passage one of "Bogue"s planes sighted and bombed surfaced , 12 December. "Du Pont" and continued the attack, driving the submarine to the surface on the morning of the following day. The destroyers opened fire and after the submarine's conning tower exploded, rescued 46 survivors including the captain as "U-172" sank in . "Du Pont" shared in the Presidential Unit Citation awarded the "Bogue" task group for distinguished success in operations against submarines.