In the 18th century the River Etherow was known as the Mersey. The River Tame has been a border from the earliest times between the Anglo-Saxon kingdoms of Northumbria and Mercia. The ancient parish was the most northerly in Cheshire. Mottram came to prominence as a transport hub. It lies on two pack horse routes used to carry salt from Cheshire to South Yorkshire over the Pennines and carry lime for soil improvement from Chapel-en-le-Frith. It was on the Manchester to Sheffield stage coach route, and had a flyer service to Manchester. Before the Industrial Revolution Mottram and Ashton had been the most significant towns in the area, the manor and manorial court house were in Mottram, but other towns eclipsed Mottram in size and importance. Mottram was active in the early stages of industrialisation, and there were significant cotton spinning mills in Wedneshough Green and the Treacle Street areas of Mottram Moor, and printing and dyeing works on the Etherow at Broadbottom which until recently was part of the parish.