She appeared as the prostitute girlfriend of Gypo Nolan in John Ford's "The Informer" (1935). She followed this performance with a role as Milady de Winter in "The Three Musketeers" (1935). She was reunited with Walter Abel, her leading man in "The Three Musketeers", a dozen years later in "The Fabulous Joe" (1947), which was produced by Bebe Daniels. As the character Emily Terkle, Grahame was appearing in her first film since "The Buccaneer" (1938). Starring opposite Fredric March, Grahame faced the challenge of playing the love interest rather than a siren. She appeared in "The Romantic Age" in 1949.