In Vietnam, the group's responsibilities included housing numerous tenant organizations including Seventh Air Force, base defense, and liaison with Republic of Vietnam Air Force. While serving in this capacity the 377th underwent numerous enemy attacks. It was also responsible for Binh Thuy Air Base, South Vietnam between 12 May and 1 July 1970. The group provided support for Seventh Air Force flying operations with from June to December 1966, and again after September 1971. From this date it also supported Lockheed C-130 Hercules aircraft deployed to the control of the 834th Air Division.