The novel begins with an unnamed narrator's arrival in Medicine Bow, Wyoming, from "back East" and his encounter with an impressively tall and handsome stranger. The stranger proves adept at roping horses, as well as facing down a gambler, Trampas, who calls him a "son of a bitch." (At the time, the word was an unacceptable insult in any society, except between joking friends.) The stranger lays a pistol on the table and gently threatens, "When you call me that, smile!" Known only as the Virginian, the stranger turns out to be the narrator's escort to Judge Henry's ranch in Sunk Creek, Wyoming. As the two travel the 263 miles to the ranch, the narrator, who is nicknamed the Tenderfoot, and the Virginian come to know one another as the Tenderfoot slowly begins to understand the nature of life in the West, which is very different from what he expected. This meeting is the beginning of a lifelong friendship and the starting point of the narrator's recounting of key episodes in the life of the Virginian.