Another possible exploitation of PRRs in human medicine is also related to tumor malignancies of the intestines. "Helicobacter pylori" has been shown by studies to significantly correlate with the development of a gastrointestinal tumors. In a healthy individual "Helicobacter pylori" infection is targeted by the combination of PRRs, namely TLRs, NLRs, RLRs and CLR DC-SIGN. In case of their malfunction, these receptors have also been connected to carcinogenesis. When the "Helicobacter pylori" infection is left to progress in the intestine it develops into chronic inflammation, atrophy and eventually dysplasia leading to development of cancer. Since all types of PRRs play a role in the identification and eradication of the infection, their specific agonists mount a strong immune response to cancers and other PRR-related diseases. The inhibition of TLR2 has been shown to significantly correlate with improved state of the patient and suppression of the gastric adenocarcinoma.