Carrying her good form into the Rogers Cup, she was seeded 16th and she saw off Putintseva and Christina McHale before upsetting fourth seed Agnieszka Radwańska for a place in her fifth quarterfinal of the year. There, she was defeated by eventual runner-up Madison Keys in three sets. Making her debut appearance at the Summer Olympics in Rio de Janeiro, Pavlyuchenkova defeated Pole Magda Linette in the opening round but was then beaten by eventual gold medallist Monica Puig in the second round. She then lost in the round of 16 at Cincinnati to Garbiñe Muguruza. At the US Open, Pavlyuchenkova reached the third round where she was beaten by eventual runner-up Plíšková.