There are few explicit discussions of scientific methodologies in surviving records from early cultures. The most that can be inferred about the approaches to undertaking science in this period stems from descriptions of early investigations into nature, in the surviving records. An Egyptian medical textbook, the Edwin Smith papyrus, (c. 1600 BCE), applies the following components: examination, diagnosis, treatment and prognosis, to the treatment of disease, which display strong parallels to the basic empirical method of science and according to G. E. R. Lloyd played a significant role in the development of this methodology. The Ebers papyrus (c. 1550 BCE) also contains evidence of traditional empiricism.