The premise of the animated series differs in a number of ways from the original "Beetlejuice" live-action film. In the TV series, he and Lydia are best friends, Beetlejuice is made out to be more of a prankster, and Lydia is given a much quirkier, but positive demeanor. Lydia often travels to the 'Neitherworld' (changed from 'Afterlife') to have adventures with Beetlejuice. These adventures could involve fun activities together, Lydia saving Beetlejuice from a bad situation, or scolding him for a money making scam.