After the cancellation of "Arrested Development" in April 2006, Tambor signed on to a series with John Lithgow called "Twenty Good Years" about two men who ponder the last 20 years of their life. The show premiered on NBC on October 11, 2006, but was taken off the air after only a few episodes. Also in 2006, he portrayed George Washington on "The Radio Adventures of Dr. Floyd". He starred as "Uncle" Saul in the CBS comedy "Welcome to The Captain" until its cancellation in March 2008. He has made several cameo appearances on "Entourage" as a fictionalized version of himself who regularly annoys his agent, Ari Gold.