After seven years with A&M, he signed with Motown. In 1979, he duetted with Syreeta Wright on the ballad "With You I'm Born Again", which reached number 4 on the charts in the US. Preston's career lost momentum in the 1980s due to his cocaine and alcohol addictions. He left Motown in 1984 and focused on session work, contributing to works by artists such as Luther Vandross (his organ solos were included on Vandross' 1985 hit "Til My Baby Comes Home"), Whitney Houston and Patti LaBelle, among others. He served as musical director for "Nightlife", a late-night talk show hosted by David Brenner that lasted one season from 1986 to 1987.