The station features a variety of programming, including most genres of music, talk shows, and coverage of ISU sporting events. Hip-hop, electronica, rock, americana, classical, and jazz are just a few of the music genres played by KURE's constantly rotating staff of student DJs. Music played at KURE is selected by DJs with some influence from a board of student music reviewers. Sections of non-primetime schedule that are not covered by a dedicated DJ are filled by an automated music system, which staff have nicknamed "Ottobot". The station also provides coverage of Iowa State football, basketball, and wrestling. Additionally, this station provides occasional news and talk style programming.