Through 1943, VMJ-253 supported operations on Bougainville, New Georgia, Vella Lavella, and numerous islands throughout the Solomon chain. As the island-hopping campaign moved into the Central Pacific in 1944, so did VMJ-253. Detached from SCAT, VMJ-253 officially became a transport squadron and was redesignated VMR-253. VMR-253 was assigned to the Transport Air Group, popularly called TAG, which was the Central Pacific version of SCAT. Continuing the heavy schedule of lifts from Tarawa, VMR-253 sortied to Kwajalein, Roi-Namur, and Eniwetok. In October 1943, VMR-253 moved to Guam. Working out of Guam, VMR-253 supported actions on Tinian, Saipan, and Peleliu. VMR-253 remained on Guam until the close of the war, and in May 1946, returned to MCAS Miramar.