Her first major role in television was as a producer for the PBS show "Soul!", hosted by Ellis Haizlip, which aired between 1967 and 1973. One of her first TV appearances was in 1973 on the first run syndication game show of "To Tell the Truth" where she was an imposter for Laura Livingston, one of the first female military police. Horsford made guest appearances on such sitcoms as "The Fresh Prince of Bel-Air", "Sparks", "Moesha", "The Bernie Mac Show", "The Shield", "Girlfriends", and "Everybody Hates Chris". She had main roles on the sitcoms "The Wayans Bros." as "Dee Baxter" and "Thelma Frye" on "Amen". She appeared on the drama "Judging Amy".