Dr. Guy Luthan (Hugh Grant) is a New York emergency room doctor who one night comes across a strange patient: a homeless man who has a wristband from a hospital he's not familiar with, mentioning a drug he's never heard of, and with strange symptoms, including a wildly fluctuating heart rate. When the man dies, Guy attempts to follow up and find out more about the patient - only to find that the body and all records have disappeared, and he's told by his superiors to drop the case.