Cambia identified that the majority of patents claiming methods for plant transgenics make explicit reference to the bacterium Agrobacterium tumefaciens; therefore, the use of a bacterium outside the genus Agrobacterium would not be subject to existing patent claims. Cambia published its work on TransBacter, which uses bacteria from the genera Rhizobium, Sinorhizobium and Mesorhizobium in 2005 in "Nature". TransBacter is available to all non-profit researchers and institutes upon signing a BiOS MTA. For-profit companies are asked to sign a BiOS license and to make a contribution to Cambia which is calculated on the company’s financial means.