Bonino was elected to the European Parliament in 1979 and re-elected in 1984 and 1999. She served as the Secretary of the Transnational Radical Party in 1993–94 and the party's president in 1991–1993. In October 1994, she was appointed head of the Italian Government delegation to the UN General Assembly for the "Moratorium on death penalty" initiative. From 1994 to 1999, she was European Commissioner responsible for Consumer Policy, Fisheries and the European Community Humanitarian Office (ECHO). In 1997, her field of competence was widened to include consumer health protection and food safety.