There were other problems that a pope would have to face. Queen Elizabeth of England had been excommunicated by Pius V, and she had obtained possession of Mary, Queen of Scots. Mary's relatives, the Guises, were the leaders of the devout hyper-Catholic party in France, who were eager for a show-down with the Huguenots. Catherine de' Medici was attempting to avoid a civil war in France, and she believed that the marriage of her daughter Margot with Henri of Navarre, a Protestant, might avert disaster but dispensations would be required of the pope. She was also trying to tempt Queen Elizabeth into marriage with her son, Henri, and that would require papal cooperation as well. Her choice was the Cardinal of Ferrara, Ippolito d'Este, who was as disliked in 1572 as he had been in 1549. His collection of enemies had grown to include Cardinals Bonelli, Borromeo, Farnese, Medici, and Morone. Catherine, however, was in contact with her cousin, Cosimo I, Grand Duke of Tuscany, who, behind the scenes, was promoting Cardinal Boncompagni. Cardinal de' Medici was to inform the leaders of the Faction of Pius IV, Borromeo and Altemps, that the Medici were interested only in Sirleto and Boncompagni. With the French and Florentine votes, in fact, Cardinal d'Este had the resources to block any candidate he pleased (the 'virtual veto').