On November 23, at Survivor Series, Edge returned to WWE after an introduction by SmackDown General Manager and his on-screen wife Vickie Guerrero, replacing Jeff Hardy in the Triple Threat match for the WWE Championship involving champion Triple H and Vladimir Kozlov. He pinned Triple H to become the WWE Champion for the third time in his career. The following month, Edge lost the title to Hardy at Armageddon in a triple threat match, which also featured Triple H. At the Royal Rumble, however, Edge regained the title in a no disqualification match, following Matt Hardy's interference. The following month at No Way Out, Edge lost the WWE Championship in an Elimination Chamber match after being pinned by Jeff Hardy, being the first to be eliminated, with the title eventually being won by Triple H. Later that night, Edge inserted himself into the World Heavyweight Championship Elimination Chamber match after attacking Kofi Kingston and barricading himself inside one of the chamber's pods, proceeding to win his fourth World Heavyweight Championship, last eliminating Rey Mysterio and taking the title over to SmackDown. At WrestleMania 25 in April, Edge lost the championship to John Cena in a Triple Threat match, which also included Big Show, but regained the championship for a fifth time at Backlash, when he defeated Cena in a Last Man Standing match, after interference by Big Show. After a successful defense against Jeff Hardy at Judgment Day, he lost the title to Hardy at Extreme Rules in a ladder match. While Hardy was celebrating, CM Punk cashed in his Money in the Bank and defeated Hardy to win the World Heavyweight Championship. The following night on "Raw", Guerrero resigned as the Raw General Manager due to being humiliated, and Edge came out to apologize. Instead, however, he confessed he married Guerrero only because she had authoritative powers as the General Manager, and sought a divorce. On the June 15 episode of "Raw", Edge received his rematch for the World Heavyweight Championship in a triple threat match against both Hardy and Punk, but was pinned by Punk.