After DASH qualifications off the Virginia Capes, the destroyer operated along the east coast until getting underway for the Far East on 4 October. Steaming via the Panama Canal, Hawaii, Japan, and the Philippines, the destroyer arrived off the coast of North Vietnam on 7 January 1967. While in the war zone "Myles C. Fox" delivered numerous fire support missions against enemy ground forces and installations. Her guns also damaged three enemy junks and two sampans. She headed home on the second half of a round-the-world cruise 20 February and arrived Newport from Suez and Gibraltar 25 April.