North of Whitney Road, NY 250 becomes Fairport–Nine Mile Point Road as it descends and ascends a series of small hills populated by homes on its way into Penfield. About north of the town line and north of Fairport, the route enters Lloyd's Corners, a commercial district surrounding NY 250's junction with NY 441. The residential surroundings return north of the intersection, however, as the route approaches a junction with Whalen Road. Past this point, the homes begin to get further spaced apart as NY 250 heads northeastward into a rural area of eastern Monroe County. It remains on a northeastward course for just over before curving back to the north at a junction with NY 286 (Atlantic Avenue), its last major intersection before entering the town of Webster as Webster Road.