About later, the highway reenters a more populated area that delimits the southern edge of the village of Webster. Now South Avenue, NY 250 heads north through the densely populated southern half of the community, passing by Spry Middle School on its way into the village center. Once again, the homes are supplanted by businesses as NY 250 and NY 404 (Main Street) meet at the heart of the business district. North of the junction, the route changes names to North Avenue and connects to the Irondequoit–Wayne County Expressway (NY 104) at an interchange just two blocks from NY 404. It continues on, crossing the Ontario Midland Railroad before leaving the village and becoming Webster Road once more. The highway heads onward through mostly residential areas of northeastern Webster to Lake Road (formerly part of NY 18), where NY 250 ends from the Lake Ontario shoreline at Nine Mile Point.