Lying on Watling Street, the Roman road (subsequently the A5 until de-trunking) between St Albans and Dunstable, it was a major coaching stop on the highway from London to Birmingham, at one point having over forty inns and public houses along its main road, and the village was one of the earliest sites of the Pickfords transport service, one road out of the village being named Pickford Road. During the 12th century Christina of Markyate was the Prioress of a Benedictine community in the area.