On 22 September, "Sickle" left Algiers to patrol the Gulf of Genoa in the same area as in her previous patrol. In the evening of 28 September, the submarine landed two men near Sestri Levante, Italy; their mission was to gather intelligence as well as organize resistance movements and escapes of Allied prisoners of war to Switzerland. On 30 September and 3 October, "Sickle" attacked a small coastal trading vessel and a submarine chaser with three torpedoes each, missing with all six. The boat then returned to Algiers on 10 October.