He was elected as a Conservative Member of Parliament for Daventry in the 1979 general election. Lady Hesketh was instrumental in him standing for Daventry. He was a Minister of State at the Department of Health and Social Security in Margaret Thatcher's government between 1979 and 1981. He left the government owing to ill health. He was knighted in 1987, the year he stepped down as an MP. On 30 January 1992, he was created Life Peer as Baron Prentice, of Daventry in the County of Northamptonshire.