In the field of hydrogen production, the incorporation of chemical compounds in electrochemical devices to produce molecular hydrogen has been a topic of huge interest in the recent years due to the possibility of using hydrogen as a replacement of the fossil fuels as an energetic carrier. This approach of using materials inspired by natural models to do the same function as their natural counterparts is called bio-mimetic approach. Nowadays this approach has received a big impulse due to the availability of high-resolution crystal structures of several hydrogenases obtained with different techniques. The technical details of these hydrogenases are stored in electronic databases at disposition to who may be interested.