The routing of PA 60 was originally designated as part of US 22 and US 30 in the 1920s. In 1953, US 22 and US 30 were rerouted to follow a new highway to the south while the former routing of the two routes through Crafton became PA 60 in January 1956. The PA 60 designation was gradually extended northward as sections of the Airport Parkway and the Beaver Valley Expressway were built in the 1960s and 1970s, with the route eventually extending as far northward as US 62 Business in Sharon. For years, a gap existed in PA 60 between West Mayfield and New Castle; it was filled on November 20, 1992, with the opening of a toll road between the two locations.