In "52", it is implied that Lady Styx put a bounty on the heads of Starfire, Adam Strange, and Animal Man, DC heroes who had been stranded in space following the events of "Infinite Crisis". Seeing the destruction wrought by her followers and fearing their homeworlds could be next, the trio of space heroes decide to make a stand against her. They are begrudgingly aided by the former intergalactic bounty hunter Lobo, who takes them to the Lady on the pretense of collecting on their bounty. The resulting battle leads to the apparent death of Animal Man via a necrotoxin (though he was later resurrected by the very aliens who originally gave him his powers). Lady Styx is apparently killed in Week 36 of "52", absorbed by a Sun-Eater while battling the Green Lantern Ekron (a.k.a. the "Emerald Head"). Some time later, she's able to grow new flesh for herself from a pregnant captive.