Around the beginning of 1449, Branković imprisoned Hungarian regent John Hunyadi in the dungeons of the fortress until he was ransomed by his countrymen. In 1453, Sultan Mehmed II and Isak-bey Arbanazović led another attack on Smederevo as part of a devastating raid on Serbia. The Turks took 50,000 men, women and children during that raid, but Smederevo was well-led by Thomas Kantakouzenos. Despite having only 6,000 men, compared to the Ottomans' 20,000, the city withstood. Mehmed the Conqueror besieged Smederevo for the second time and the fortress was besieged by the Ottomans for the third time in 1456, being defended by Serbian forces. In March 1459, Stephen Tomašević took over command of Smederevo Fortress. In 1459, Smederevo was captured by the Ottomans, leading to the end of the medieval Serbian state while Stephen Tomašević flead to Bosnia