Džeko began the new 2012–13 season with an equalising goal against Southampton in a 3–2 win. He scored another goal against Queens Park Rangers taking his tally to two goals in the opening three games. He then scored the first goal of City's Champions League campaign against Real Madrid at the Santiago Bernabéu. On 29 September, he scored an 87th-minute winner away at Fulham, one minute after appearing as a substitute. On 20 October, he came off the bench in the 79th minute to score a minute later. He scored a second goal two minutes into stoppage time to seal a comeback win for 10-man City against West Bromwich. On 11 November, Džeko scored another late winning goal as a substitute with a left-footed volley in the 88th minute against Tottenham Hotspur. On 29 December 2012, he scored two goals against Norwich City in a 4–3 victory.