In a game against Cagliari on 6 October 2019, Džeko fractured his zygomatic bone (cheekbone), needing to go get surgery and afterwards wear a protective mask in some of his first games after the recovery. He scored his 5th goal in the season for Roma in the club's 2–1 home league win against Milan on 27 October 2019. With a goal in a UEFA Europa League game against Wolfsberger on 12 December 2019, which Roma tied 2–2, Džeko qualified his team to the last 16 of the 2019–20 UEFA Europa League season.