PA 60 begins in the West End of the city of Pittsburgh at a complex intersection with US 19 and PA 51 that also serves as the northern terminus of PA 837. It heads southwestward along South Main Street through the West End before curving to the south and following Noblestown Road south and west around the Elliott neighborhood. The route continues into Crafton Heights, where it meets the eastern terminus of PA 50. Here, the Noblestown Road name follows PA 50 to the south while PA 60 heads westward as Crafton Boulevard into the borough of Crafton. Just inside the borough, the route makes a sharp turn to the south, generally paralleling the borough limits to the intersection of Crafton Boulevard and Dinsmore Avenue.