After being discovered unconscious on the bathroom floor at home due to a heroin overdose, Christiane tries going cold turkey with Detlev, an excruciating experience for both of them. However, they both relapse the moment they revisit Bahnhof Zoo. To fuel her addiction, Christiane steals from home, sells all her possessions, and sinks to abysmal levels. One day, Christiane and Detlev find their best friend and roommate, Axel, dead in the apartment from a fatal overdose, due to a bad batch of heroin he was sold on the streets that Detlev believes to be strychnine. Christiane and Detlev quickly run away, ending up at the apartment of one of Detlev's male clients. When Christiane walks in on the two having very loud anal intercourse, she has a breakdown and flees. She returns to the station in order to find Babsi, only to discover that she is dead of an overdose at barely 14 years old, as plastered all over the front pages of many newspapers. In despair over the deaths of numerous friends, as well as her inability to break free from her heroin addiction, Christiane tries to overdose too. The film abruptly breaks to an off-camera voiceover that says eventually Christiane recovered, but most of her cohorts either died or are still addicts, including Detlev, whose whereabouts and current condition are unknown.