Plaistow's economy is centered along New Hampshire Route 125, a north–south road that connects the town with Haverhill, Massachusetts, to the south and Kingston, Epping, and Rochester, New Hampshire, to the north. Local businesses and numerous large chain stores are located along Route 125, which has become known for problems with heavy traffic during weekday commuting and weekend shopping hours. Route 125 intersects with Interstate 495 in Massachusetts south of the center of Plaistow. Commuters to Massachusetts are able to use a New Hampshire park and ride facility located on Westville Road, just east of Route 125.