"Robert F. Keller" was ready for the operation by 21 March 1945 and proceeded to Okinawa, destroying three floating mines en route. Her duties were identical to those she had known in the Iwo campaign, acting as air defense and antisubmarine screen for the carriers involved in covering the invasion from the air. The ship left the area on 27 April escorting the escort carrier to Ulithi. She was back in the war on 10 May escorting the cruiser to the Okinawa battleline and then guarded the convoy lanes around the beleaguered island fortress. She returned to Leyte for availability on 17 June.