Calhoun County was settled by Americans during the very early 19th century, and officially organized in 1825. It was named for Vice President John C. Calhoun, in addition to the Calhoun family that was prominent in the area at the time. The southern side of the county, covered in thick forest, was untouched until the population began to expand in the late 1840s with the arrival of German immigrants. Land was cleared for farming, exporting lumber, and constructing spacious log barns, typically in size, which were a "trademark of successful German farmers."