Lee is on Interstate 90 (the Massachusetts Turnpike), and is home to Exit 2, the westernmost full exit on the turnpike (Exit 1, in West Stockbridge, is only a turnaround exit) as well as the first service area along the Pike. Lee is also on U.S. Route 20, the "old Mass Pike", which was the main route to New York until the interstate. A small section of U.S. Route 7 crosses through the northwest corner of town before meeting Route 20 in Lenox. Massachusetts Route 102's eastern terminus is at Route 20 at the Exit 2 toll plaza.