Route 10 crosses Interstate 95 at a full interchange, sometimes known as the "Friendly Interchange" for the community of Quakers it partially destroyed. It then heads northwest, crossing under Pontiac Avenue and then junctioning Route 2 (Reservoir Avenue) just after crossing back into Providence. After the Route 2 interchange, Route 10 again crosses back into Cranston, running west of the parallel Niantic Avenue, which is on the city line. The final crossing, back into Providence, is just after the Cranston Street interchange, where Niantic Avenue ends.