Note that labile protons (-OH, -NH2, -SH) have no characteristic chemical shift. However such resonances can be identified by the disappearance of a peak when reacted with D2O, as deuterium will replace a protium atom. This method is called a D2O shake. Acidic protons may also be suppressed when a solvent containing acidic deuterium ions (e.g. methanol-"d"4) is used. An alternate method for identifying protons that are not attached to carbons is the heteronuclear single quantum coherence (HSQC) experiment, which correlates protons and carbons that are one bond away from each other. A hydrogen that is not attached to a carbon can be identified because it does not have a crosspeak in the HSQC spectrum.