Many researchers from the 1860s onwards attempted to find evidence for Lamarckian inheritance, but these have all been explained away, either by other mechanisms such as genetic contamination or as fraud. August Weismann's experiment, considered definitive in its time, is now considered to have failed to disprove Lamarckism, as it did not address use and disuse. Later, Mendelian genetics supplanted the notion of inheritance of acquired traits, eventually leading to the development of the modern synthesis, and the general abandonment of Lamarckism in biology. Despite this, interest in Lamarckism has continued.