The airline was established in 1999 and started operations on December 19, 2001 with two Boeing 737-200 aircraft. It was owned and operated by Vikrom Aisiri and his wife Angkana Apiwattanaporn. Aisiri is a Thai businessman and senator from Ranong who also owns the Andaman Club Hotel & Casino in Myanmar and a Dusit Island resort hotel in Chiang Rai Province. Phuket Air flew domestic routes to Phuket, Chiang Mai, Krabi, Chiang Rai, Hat Yai, Ranong and Mae Sot. Ranong operations were used by tourists visiting the Andaman Club Hotel & Casino, across the border in Myanmar.