Variolation confers personal immunity, and if widespread would be a "service to mankind" by furthering herd immunity. However, deliberate infection with the smallpox virus ran the risk of disfigurement or death. (Queen Caroline, wife of George II, was an advocate and had three of their children variolated, but Jonathan Edwards died from it in 1758.) The public good, then, could appear to be at odds with private interest. In his first publication, "Some Reasons why the Practice of Inoculation ought to be Introduced into the Town of Bury at Present" (1733), Hartley developed a statistical argument to show that the conflict is only apparent, that being inoculated furthers both the public good and a person's self-interest.