In 1942, he joined Bombay Talkies at an offer from Devika Rani, where he got his biggest hit, Gyan Mukherjee's "Kismet" (1943), starring Ashok Kumar and Mumtaz Shanti, most remembered for the song, 'Papihaare', sung by his sister Parul Ghosh (wife of the renowned flautist, Pannalal Ghosh), the patriotic hit, 'Door hato ai duniyaa waalo', and 'Dheere dheere aare badal, mera bulbul so raha hai, shorgul na macha' sung by the actor, Ashok Kumar. In 1946, he left Bombay Talkies and set out as a freelancer, and later under the banner, ‘Variety Pictures’ owned by his wife, AshaLata Biswas, worked for four films, "Laadli" (1949), "Laajawaab" (1950), "Badi Bahu" (1951) and "Humdard" (1953), with KA Abbas "Rahi" (1952), songless "Munna" (1954), where he gave the background score, and Indo-Russian joint production, Nargis starrer, "Pardesi" (1957) and "Char Dil Char Rahen" (1959). By now, the kind of music perfect by "Anilda", as he was now called in the industry as, was fast changing, and so he gradually grew disillusioned by the changing dynamics of the film industry. In early 1960s, he retired from the cinema, while still at the peak of his game, he shifted base to New Delhi, though he did one or two films in between like Mahesh Kaul's, "Sautela Bhai" (1962), his final film as a composer was, actor Motilal's directorial venture, "Chhoti Chhoti Baatein" (1965), starring Nadira and with Mukesh's 'Zindagi Khwab Hai Tha Hamein Bhi'. Motilal died before its release, and the film flopped at the box office, though it did get a National Film Award.