Jackson played the title character's best friend, Niecy Jackson, on the television show "Moesha". She has also appeared in "The Bernie Mac Show" and "My So-Called Life" as Crystal. She co-starred in the Nickelodeon movie "Good Burger" with Kel Mitchell and Kenan Thompson. Jackson was also featured on the ABC reality series "The Ex-Wives Club" with Marla Maples and Angie Everhart. The show aimed to aid men and women who have recently gone through separation or divorce. In 2009, Jackson appeared in the film "I Do... I Did!". She also appeared in the dance film "".