DeBakey offers pre-advanced placement classes in foreign languages, mathematics, science, social sciences, and English in 9th and 10th grade, as well as 18 Advanced Placement classes: AP English Literature, AP English Language, AP Spanish Language, AP World History, AP US History, AP Computer Science, AP Calculus AB, AP Calculus BC, AP Macroeconomics, AP US Government and Politics, AP Physics 1, AP Physics 2, AP Statistics, AP Chemistry, AP Biology, AP Environmental Science, AP Psychology, and AP Studio Art, which includes 2-D Design and Drawing.