In January 1969, VMA(AW)-225 deployed to Da Nang Air Base, Vietnam. The primary mission of Marine All Weather Attack Squadron 225 was to provide close air support and direct air support for ground elements for allied forces in the I Corp area of South Vietnam. The squadron attacked and destroyed surface targets day and night, and in all weather conditions. A secondary mission was to utilize the Intruder's unique search radar Airborne Moving Target Indicator (AMTI) features in the interdiction of trucks on the Ho Chi Minh Trail in Southeast Asia. During May 1971, VMA(AW)-225 returned to MCAS El Toro, California, and the squadron was deactivated on June 15, 1972.