Capuano was invited to the Milwaukee Brewers' spring training for the 2010 season, but early on he complained of arm soreness and was placed in extended spring training. He would start the regular season with the Single A, Brevard County Manatees of the Florida State League. Capuano would only need 3 appearances with the Manatees before being promoted to the Triple A Nashville Sounds. In those 3 appearances, Capuano registered a 2–0 record with a 1.23 ERA and 17 strikeouts in 14 innings pitched. On May 28, 2010, Capuano made his final start for the Sounds, and was pulled after four innings. After the game, it was announced the Brewers had purchased his minor league contract and he was recalled to the majors.