Wellington Street begins at Plain Street in East Perth, as the continuation of Waterloo Crescent. It travels in an east-north-easterly direction, passing the Wellington Square park. In the suburb of Perth, Wellington Street is adjacent to a number of notable buildings and landmarks, including Royal Perth Hospital, Forrest Chase shopping centre, Perth railway station, Wellington Street bus station (now demolished), Perth Entertainment Centre and Perth Arena, before reaching the Mitchell Freeway. The road passes under the freeway with a half-diamond interchange that has a southbound freeway exit ramp and a northbound entrance ramp. Wellington Street continues into West Perth, past Harbour Town and commercial properties, until it ends at an intersection with Thomas Street and Roberts Road, near Princess Margaret Hospital.