Zenden played in all five Dutch matches at Euro 2000. Carrying his pre-tournament form into the tournament proper, Zenden grabbed a goal against Denmark and the winner against France to help the Netherlands finish top of Group D. The Dutch annihilated Yugoslavia 6–1 in the quarter-final; Zenden once again put in a stellar performance, including the assist for what turned out to be Kluivert's hat-trick goal. He started the semi-final against Italy, but he was substituted in a game that would see the Dutch be eliminated on penalties.