"Xombie" tells the story of a little girl named Zoe, who washes ashore years after a zombie plague has wiped out most life on Earth and replaced it with bloodthirsty reanimated versions of the planet's previous inhabitants. She is saved from a swarm of zombies by Dirge, a "variant", a zombie who has retained their conscious mind and the ability to think like a human. (According to the official website, the variants are called "xombies", but the term has yet to be used in the series itself, likely because it is pronounced the same way as "zombie".) Dirge takes it upon himself to perform one last good deed before his zombie body withers away and begins a journey to reunite Zoe with the few remaining live humans and save her from a gruesome death at the hands of the undead.