Pavlyuchenkova has won twelve singles and five doubles titles on the WTA Tour, as well as five singles and eight doubles titles on the ITF Women's Circuit. Her biggest singles titles to date have come at two Premier-level tournaments, the 2014 Open GDF Suez and the 2014 Kremlin Cup. She is a six-time Grand Slam quarterfinalist, having reached that stage at all four Grand Slams (at the 2011 French Open, the 2011 US Open, the 2016 Wimbledon Championships, and the 2017, 2019 and 2020 Australian Opens).