Manfredini did not stay any longer though as he had caught the eye of giants Lazio, who he joined in 2002 in co-ownership deal for €6.715 million or 13 billion lire (10 billion lire cash (€5.165 million cash) plus half of registration rights of Pesaresi tagged for €1.549 million or 3 billion lire). Lazio later write-down the value of Manfredini to €2.3 million, after both club withdrew the remain 50% registration rights. At first, Manfredini failed to break into the strong Lazio side and was sent on loan to Osasuna in Spain, as well as Perugia and Fiorentina.