Due to the 2021 full-scale reorganization of Minor League Baseball, there was much speculation as to what would happen to independent leagues such as the American Association and specifically the Saints. On November 11, 2020, it was reported that the Minnesota Twins ended their 18-year affiliation with their Triple-A affiliate, the Rochester Red Wings. At this time it was also reported that the Saints were a front-runner to be the Twins' new Triple-A affiliate. The main barrier to a deal was said to be the $20 million fee required for affiliation. The Twins aided in this by becoming minority shareholders in the Saints and placing their Triple-A affiliation in St. Paul beginning with the 2021 season. The Saints were organized into the 20-team Triple-A East. At a distance of 12.9 miles (along Interstate 94, including surface streets), CHS Field is the closest Triple-A ballpark to its MLB parent team.