Golota received his third world title try in a row on 21 May 2005 against WBO champion Lamon Brewster. Though heavily favored to win, Gołota lost when Brewster knocked him down three times inside the first round, prompting the referee to stop the bout. On 9 June 2007, he beat Jeremy Bates in the 2nd round by technical knockout. Gołota fought Kevin McBride on October 6, 2007 in Madison Square Garden and won by TKO in the 6th round, winning the inaugural IBF North American Heavyweight championship.