The first historically documented bishop of Cumae was Adeodatus, a member of a synod convoked by Pope Hilarius in Rome in 465. Another was Misenus, who was one of the two legates that Pope Felix III sent to Constantinople and who were imprisoned and forced to receive Communion with Patriarch Acacius of Constantinople in a celebration of the Divine Liturgy in which Peter Mongus and other Miaphysites were named in the diptychs, an event that led to the Acacian Schism. Misenus was excommunicated on his return but was later rehabilitated and took part as bishop of Cumae in two synods of Pope Symmachus. Pope Gregory the Great entrusted the administration of the diocese of Cumae to the bishop of Misenum. Later, both Misenum and Cumae ceased to be residential sees and the territory of Cumae became part of the diocese of Aversa after the destruction of Cumae in 1207. Accordingly, Cumae is today listed by the Catholic Church as a titular see.