Along with San Antonio, Uvalde, Crystal City, Carrizo Springs, and Corpus Christi, Pleasanton was a major stop on the now-defunct San Antonio, Uvalde and Gulf Railroad, which operated from 1909 until it was merged into the Missouri Pacific Railroad in 1956. The rail headquarters was located in a modern two-story depot in North Pleasanton beginning in 1913. However, headquarters closed in 1926, and later the SAU&G, or the Sausage Line as it was called, was merged into the Missouri Pacific. The headquarters depot has been razed, but an earlier depot in Pleasanton is displayed at the Longhorn Museum. The remaining San Antonio-to-Corpus Christi freight line is under the Union Pacific system.