While the majority of gay manga artists produce works targeting a gay male audience exclusively, Tagame is noted for having a significant heterosexual and female audience. Tagame has stated that he adjusts his style if a work is being published in a format where it will be primarily read by a specific subset of his audience, noting that "when I write for gay men's magazines, it's primarily about the hero's initiative and interiority. When I know that women are also going to be reading it [...] they're more interested in seeing actual relationships and coupling." In considering why Tagame's works attract a diverse audience, Anne Ishii hypothesizes that "something about what Tagame does isn't even about being gay [...] it's about desire and the darker side of desire. It doesn't fit into a sexual category to me."