As his father advanced through the executive ranks of Armour and Company, the family lived in Greenville, Jackson, and Vicksburg, Mississippi, as well as Pensacola, Florida and Mobile, Alabama. Foote's father died in Mobile when Foote was five years old; he and his mother moved back to Greenville to live with her sister's family. Foote was an only child, and his mother never remarried. When Foote was 15 years old, he began what would become lifelong friendships with Walker Percy and his brothers LeRoy and Phinizy Percy who'd just moved into Greenville to live with their uncle – attorney, poet, and novelist William Alexander Percy – after the death of their parents. Foote began a lifelong fraternal and literary relationship with Walker; each had great influence on the other's writing.