The Columbia Parkway in Cincinnati was completed in 1941 and US 50 was rerouted onto the parkway. The road west of Cincinnati became a four-lane divided highway in 1949. In 1965 the Sixth Street Expressway open and US 50 was rerouted onto the expressway. Also in that year the section of US 50 that is concurrency with SR 7 became a four-lane divided highway. US 50 was routed onto the eastern section of the Athens bypass when it open, in 1977. The western section was opened in 1979 and US 50 was route onto that year. US 50 between Athens and Coolville became a four-lane divided highway between 1997 and 1999. Between 2003 and 2007 a new bridge across the Ohio River was built.