RLRs, are RNA helicases, which have been shown to participate in intracellular recognition of viral double-stranded (ds) and single stranded RNA which recruit factors via twin N-terminal CARD domains to activate antiviral gene programs, which may be exploited in therapy of viral infections. It has been suggested that the main antiviral program induced by RLR is based on ATPase activity. RLRs often interact and create cross-talk with the TLRs in the innate immune response and in regulation of adaptive immune response.