Like most rural areas throughout Southeast Missouri, voters in Howell County generally adhere to socially and culturally conservative principles which tend to influence their Republican leanings. In 2004, Missourians voted on a constitutional amendment to define marriage as the union between a man and a woman—it overwhelmingly won in Howell County with 83.36 percent of the vote. The initiative passed the state with 71 percent of support from voters. In 2006, Missourians voted on a constitutional amendment to fund and legalize embryonic stem cell research in the state—it failed in Howell County with 57.97 percent voting against the measure. The initiative narrowly passed the state with 51 percent of support from voters as Missouri became one of the first states in the nation to approve embryonic stem cell research. Despite Howell County's longstanding tradition of supporting socially conservative platforms, voters in the county have a penchant for advancing populist causes like increasing the minimum wage. In 2006, Missourians voted on a proposition (Proposition B) to increase the minimum wage in the state to $6.50 an hour—it passed Howell County with 67.79 percent of the vote. The proposition strongly passed every single county in Missouri with 78.99 percent voting in favor. (During the same election, voters in five other states also strongly approved increases in the minimum wage.)