In 1955 he married Yocheved (Jackie) Levin, who had been born in Vaskai, Lithuania, in 1934 and had emigrated to Detroit with her parents at the age of 4. Jackie's father, Rabbi Eliezer Levin, served as Rabbi of Congregation Beth Tefiloh Emanuel and led the triumvirate of the Council of Orthodox Rabbis (COR) of Greater Detroit, in that city, for over 60 years. The couple settled in Chicago, where their four children—Miriam, Dinah, Chaim Tzvi, and Sori—were born. Rabbi Wein has 29 grandchildren and 70 great-grandchildren living in both Israel and America.