Combat in "Killer7" occurs when the player encounters enemies called "Heaven Smiles". Smiles announce their presence with a laughing sound effect and are initially invisible. The player must switch to a first-person viewpoint and scan the surroundings to reveal Smiles. While in first-person view, movement is disabled and the analog stick aims the character's gun. Targeting specific body parts will disable them; for example, shooting off a leg will cause a Smile to fall to the ground and crawl toward the player. The player may aim for a "critical point" that instantly destroys the Smile. Smiles that get too close will explode and injure the character. If a character dies, players can use Garcian Smith to retrieve the fallen character's head and bring them back to life; if Garcian dies, then the game ends.