During the COVID-19 pandemic, some doctors attributed many deaths to cytokine storms. Severe symptoms of acute respiratory distress syndrome (ARDS) with high mortality in COVID-19 patients are caused by a cytokine storm. SARS-CoV-2 activates the innate immune system and results in a release of a large number of cytokines, including IL-6, which can increase vascular permeability and cause a migration of fluid and blood cells into the alveoli as well as the consequent symptoms such as dyspnea and respiratory failure. The higher mortality is being linked to the result of ARDS aggravation and the tissue damage that can result in organ-failure and/or death.