Honda Tadakatsu is generally regarded as one of Tokugawa Ieyasu's finest generals, and he fought in almost all of his master's major battles. He gained distinction at the Battle of Anegawa (1570), helping in the defeat of the armies under the Azai and Asakura clans along with Tokugawa's ally, Oda Nobunaga. Tadakatsu also served at Tokugawa's greatest defeat, the Battle of Mikatagahara (1572), where he commanded the left wing of his master's army, facing off against troops under one of the Takeda clan's more notable generals, Naitō Masatoyo. Although that battle ended in defeat, Honda Tadakatsu was one of those Tokugawa generals present to exact vengeance upon the Takeda at the Battle of Nagashino (1575). Honda commanded a rank of musketeers as the combined Oda-Tokugawa forces annihilated Takeda Katsuyori's army, partly thanks to the skillful use of ranked muskets, as they fired in cycling volleys. One would fire while another was reloading and another was cleaning the barrel of the musket. This enabled the muskets to fire without stopping, effectively destroying the Takeda army. Later, he killed Takeda general, Okabe Motonobu, at the second Siege of Takatenjin (1581).