Following the one-year gap during which "52" takes place, she has reappeared in several of DC Comics' science fiction series. In "Mystery in Space", she is the source of Captain Comet's death and rebirth, a cycle which began when her forces attacked him in "52". In the 2006 "Omega Men" miniseries, Lady Styx appears as the central antagonist, seeking powerful artifacts known as "heartstones" in her attempt to remake the universe and usurp the role of God. Apparently trapped in another dimension, Lady Styx manifests in this series as a giantess.