Soon afterwards, on April 30, 1936, Carothers was elected to the National Academy of Sciences, a very high honor. Carothers was the first industrial organic chemist to receive this honor. Yet by June 1936, in spite of this honor which validated his contributions to science, Carothers could not shake the depression that prevented him from working. In early June, he was involuntarily admitted to the Philadelphia Institute of the Pennsylvania Hospital, a prestigious mental hospital, where his psychiatrist was Dr. Kenneth Appel. One month later, he was given permission to leave the institute to go hiking in the Tyrolean Alps with friends. The plan was for him to day hike with Dr. Roger Adams and Dr. John Flack for two weeks. After they left, he stayed on, hiking by himself, without sending word to anyone, even his wife. On September 14, he suddenly appeared at her desk at the Experimental Station. From that point on Carothers was not expected to perform any real work at the Experimental Station. He would often go in and visit. He began living in Whiskey Acres again, after his wife had agreed with Dr. Appel that she was not strong enough to watch over Carothers.