By the start of "The Defenders", Matt and Karen are back on speaking terms, although it is clear Karen is hesitant to resume a relationship due to her own secrets. Later, when Matt believes the Hand are targeting his loved ones, he visits Karen at her office to take her to the 29th precinct. Karen is angered when she finds out he has resumed Daredevil activities, but agrees to hide with Foggy in the 29th precinct until the Hand have been taken down. While there, she bonds with Trish Walker over their complicated relationships with Matt and Jessica Jones. When Matt is presumed killed in the destruction of Midland Circle, Karen refuses to believe Matt has died and holds out hope that he somehow survived the collapse.