In 2001, Crampton had a recurring role as Dr. Leslie Bogan in 5 episodes of the television series "Spyder Games" and starred in "Thy Neighbor's Wife". In 2004, Crampton starred in "The Sisterhood". She subsequently starred in "Read You Like a Book" (2006) and "Never Enough" (2008). Crampton was a special guest at Creation Entertainment's Weekend of Horror 2010. She had a supporting role in the 2011 horror slasher film "You're Next" and played the leading role Anne Sacchetti in "We Are Still Here" (2015), co-starring Lisa Marie and Larry Fessenden. Both films received positive reviews from critics.