Manorama was paired with Nagesh regularly in films with M.G. Ramachandran in lead like "En Kadamai, Kanni Thai, Thayin Madiyil, Kadhal Vaganam, Chandrodhyam, Anbee Vaa, Padagotti, Kadhal Vagahnam, Vivasaaye, Thaikku Thalaimagan, Vettikaran" and "Ther Thiruvizha". Other directors cast the Nagesh-Manorama pair in films like "Anubhavi Raja Anubhavi, Kungumam, Saraswathi Sabadham, Panjavarnakilli, Navarathiri, Puthiya Paravai, Patthu Matha Bandham, Anbu Karangal, Micheal Madan Kamarajan, Annamitta Kai, Gowri Kalyanam, Anbe Aaruyire, Server Sundaram, Ner Vazhai, Ninaivin Nindraval, Poojaikku Vandamalar, Deiva Thirumagal, Rakta Thilagam, Aannavin Asai, Thiruvarutchelvar, Seetha" and "Karunthel Kannayiram". Manorama, actress Sachu and Jayalalithaa have acted together in 2 films as a combination — "Galata Kalyanam" and "Bommalattam". Manorama and Jayalalithaa have acted in 25 films together.