On September 11, 2001, her younger sister and sole sibling, Berry Perkins, widow of actor Anthony Perkins, was killed in the first flight to hit the World Trade Center. Marisa was also in an airplane during the terrorist attacks, flying from Paris to New York. In an interview with CBS, she told of the experience and how hours later she landed in Newfoundland (flights were diverted to Canada), and was told of her sister's death by a phone call with her daughter. Said Berenson: "I have hope and tremendous faith. I think that's what gets you through life ... through tragedies is when you have faith."