On May 6, 2010 Guerrero hit two home runs versus the Kansas City Royals to secure a 13–12 win. On May 13, 2010, Guerrero's walk off line drive to left field won the final game of a three-game series against the Oakland Athletics in the bottom of the 12th. On May 25, 2010 he hit two more home runs to secure another win over the Kansas City Royals. On June 30, 2010, against his former team, the Los Angeles Angels of Anaheim, Guerrero hit two home runs and went 4-for-4 with 5 RBIs.