The song’s intro is featured in the 1929 film "Weary River". It is sung by the main character Jerry Larrabee played by Richard Barthelmess. The character is a gangster reformed by music. "Weary River" costars Betty Compson, who played Alice Gray, the faithful sweetheart of Larrabee, who did not like him singing Frankie and Johnny. A remarkable feature of this film is part silent film and part talkie. The film which was directed by Frank Lloyd, was nominated for an Academy Award for Best Directing.