In 1959, Lane campaigned against three other candidates for mayor and defeated Nick Nuccio in a run-off election. During his term, Lane faced a depleted treasury and a city budget of thirty million dollars. The municipal hospitals were unable to pay their bills and storm sewers were desperately needed after the havoc created by Hurricane Donna. Mayor Lane enforced stricter adherence to Civil Service hiring guidelines. He closed the Clara Frye Hospital for blacks and merged its services with the Tampa Municipal Hospital. Mayor Lane helped establish the Tampa Hospital Board and removed the hospitals from the city's direct administration.