Space and time hold little meaning within the Time Quintet series. In several instances, we find Meg and other characters frustrated with their new friends and confused about these concepts. However, according to the mythical creatures that are introduced, these concepts are limiting and unimportant. This is the key concept to understanding why Charles' sickness could be so important. His sickness, the ailment of his mitochondria is just as important as the fate of a planet elsewhere in the universe because each part of creation, great or small, is important.