Gluten intolerance in Irish Setters is a naturally occurring genetic disorder that is the result of a single autosomal recessive locus. At around 6 months of age, Irish Setters with this condition will develop an increased immune cell presence and a decrease in absorption within the small intestine when fed a gluten containing diet. These effects lead to further damage of the small intestine as well as malnutrition and diarrhea. Irish Setters that are fed a gluten free diet have been shown to be exempt from any effects associated with gluten intolerance.