In 2010, Jones bulked up to 225 pounds in order to improve his durability and was officially moved to the top of the depth chart at running back. He rushed for 109 yards on 15 carries against the Tennessee Titans, for his first 100-yard game. He played in all 16 games for the first time in his career, starting seven games together or in place of Barber and leading the team with 800 rush yards on 185 carries (4.3 yards average) and a touchdown. Against the New York Giants he had the longest reception in his career (71 yards).