In 2007, Cárdenas was extradited to the United States and charged with the involvement of conspiracies to traffic large amounts of marijuana and cocaine, violating the "continuing-criminal-enterprise statute" (also known as the "drug kingpin statute"), and for threatening two U.S. federal officers. The standoff the two agents had with the drug lord in 1999 in the city of Matamoros, Tamaulipas led for the U.S. to indict Cárdenas and pressure the Mexican government to capture him. In 2010 he was finally sentenced to 25 years in prison after being charged with 22 federal charges; the courtroom was locked and the public prevented from witnessing the proceeding. The proceedings took place in the United States District Court for the Southern District of Texas in the border city of Brownsville, Texas. Cárdenas has been isolated from interacting with other prisoners in the supermax prison he is in.