US-283 enters Oklahoma from Texas in rural Jackson County at a crossing of the Red River. It runs concurrently with State Highway 5 for several miles past Elmer and continues north to Altus, the largest Oklahoma town on the route. At the intersection of U.S. Highway 62 in Altus, SH-5 splits off and 283 joins with State Highway 6 for the next before it takes a western bend to the town of Mangum. The route continues northwesterly until it crosses I-40 at Sayre.