Neville finds a promising treatment derived from his own blood, so he sets a snare trap and captures a female Darkseeker. A male Darkseeker attempts to pursue them but is halted by the sunlight and returns to the shadows. Back in his laboratory in the basement of his house, Neville treats the female seemingly without success. The next day, Neville notices "Fred", a mannequin usually at the local video store, positioned outside Grand Central Terminal and shoots him in confusion. However, Neville realizes he is being watched by the Darkseekers from within nearby buildings. As he approaches Fred's body, he is ensnared in a trap similar to the one he used to capture the female and is rendered unconscious after hitting his head. By the time he wakes up the sun is setting and he is attacked by infected dogs. Neville and Sam eliminate them, but Sam is bitten during the fight. Neville injects her with a strand of his serum, but when she shows signs of infection, Neville is forced to strangle her to death before she turns. Heartbroken and driven by rage, Neville ventures out and deliberately attacks a group of Darkseekers the following night, before he is rescued by a pair of immune humans, Anna and a young boy named Ethan, who have traveled from Maryland after hearing his broadcast.