Oxford is located at the confluence of highways from eight directions: Mississippi Highway 6 (now co-signed with US-278) runs west to Batesville and east to Pontotoc; Highway 7 runs north to Holly Springs and south to Water Valley. Highway 30 goes northeast to New Albany; Highway 334 ("Old Highway 6") leads southeast to Toccopola; Taylor Road leads southwest to Taylor; and Highway 314 ("Old Sardis Road") leads northwest, formerly to Sardis but now to the Clear Creek Recreation Area on Sardis Lake.