During the 15th and 16th centuries, Japanese physicians began to achieve a more independent view on Chinese medicine. After 12 years of studies in China Tashiro Sanki (1465–1537) became the leading figure of a movement called "Followers of Later Developments in Medicine" ("Gosei-ha"). This school propagated the teachings of Li Dongyuan and Zhu Tanxi that gradually superseded the older doctrines from the Song dynasty. Manase Dōsan, one of his disciples, adapted Tashiro's teachings to Japanese conditions. Based on his own observation and experience, he compiled a book on internal medicine in 8 volumes ("Keiteki-shū") and established an influential private medical school ("Keiteki-in") in Kyōto. His son Gensaku wrote a book of case studies ("Igaku tenshō-ki") and developed a considerable number of new herb formulas.