After crossing into Schuyler County, NY 226 continues northeast, passing south of Mill Pond as a two-lane rural roadway. The route continues a northeastern wind for several miles through Schuyler County, entering the town of Tyrone, where it intersects with the western terminus of CR 22 a short distance from the shore of Lamoka Lake. NY 226 continues northward, intersecting with CR 23A, and a short distance later, CR 23 (Mud Lake Road). NY 226 continues north through Tyrone, running alongside a pond before bending east at an intersection with Kendall Hill Road. After the change in direction, NY 226 enters the hamlet of Altay. Through Altay, NY 226 is a two-lane residential street before leaving just after Bigelow Hill Road.