From 1941 through the end of World War II, "Chew" operated out of Pearl Harbor on patrol. She took on periodic escort duties among the Hawaiian Islands and on training duty for submarines. She made occasional trips to San Francisco and Seattle escorting convoys and screening for other Navy ships, inter-island escort, and submarine training duty. Following the end of the war, she departed Pearl Harbor on 21 August 1945 and arrived at Philadelphia 13 September. She was decommissioned there on 10 October 1945, and sold for scrap on 4 October 1946. "Chew" received one battle star for World War II service.