In 1834, McCulloch headed west. He reached St. Louis just too late to join the fur trappers headed for the mountains for the season. He then tried to join a freight company heading for Santa Fe as a muleskinner, but was told they had a full complement. He moved on to Wisconsin to investigate lead-mining, but found all the best claims already staked by the large mining companies. In the fall of 1835, he returned to Tennessee to take up farming.