Born of a poor family in Brussels (Duchy of Brabant, Southern Netherlands), during the reign of the Archduke Albert and Isabella, Champaigne was a pupil of the landscape painter Jacques Fouquières. In 1621 he moved to Paris, where he worked with Nicolas Poussin on the decoration of the Palais du Luxembourg under the direction of Nicolas Duchesne, whose daughter he would eventually marry. According to Houbraken, Duchesne was angry at Champaigne for becoming more popular than he was at court, and this is why Champaigne returned to Brussels to live with his brother.