In 2010, Nathan underwent Tommy John surgery to repair a torn ulnar collateral ligament in his throwing elbow and missed the entire season. Nathan regained the role as closer in July 2011. On August 10, 2011, he became the Twins all-time leader in saves with his 255th in a game against the Boston Red Sox. After the 2011 season, Nathan left the Twins via free agency to sign with the Rangers, becoming an All-Star again in 2012 and 2013. On April 8, 2013, he earned his 300th save. After the 2013 season, Nathan left the Rangers via free agency to sign with the Tigers. Nathan retired during the 2017 season and is currently eighth on the all-time saves list. Nathan currently has the highest save percentage in MLB history amongst pitchers with at least 250 saves.