The Notch-1 receptor pathway is another pathway that inhibits the differentiation of OPCs. When the ligands Jagged1 and Delta, produced by axons, neurons, and astrocytes, are stimulated and bind to the membrane, oligodendrocyte maturation is inhibited. This pathway may also be facilitating migration despite its differentiation inhibition. In some experiments, altering the pathway so that differentiation is increased caused a decrease in the proliferation of OPCs. There may be other ligands that have either promoting or inhibiting effects when attached to the Notch-1 receptor.