After playing a few clay-court tournaments, reaching the final in one, and having good results in the others, Melzer moved on to the hard-court season, losing to Peter Polansky in the first round of Montreal and Ernests Gulbis in the second round of Cincinnati. He then played the US Open, where he reached the fourth round for the third consecutive Grand Slam tournament, having never been past the third round prior to the French Open. He played Roger Federer for a spot in the quarterfinals, having also played him in the fourth round of Wimbledon. Federer once again defeated him in straight sets.