The site contains the remnants of Colonial New South Wales period buildings and equipment which were the best available means of combating major contagious diseases and hygiene-related conditions brought to the colony by ship. Soon after Federation the Commonwealth Government initiated a major building and infrastructure program which also remains largely intact today. This program included similar, but smaller, quarantine stations around Australian ports, of which North Head is the only remaining example. This site dealt with major shipping-related epidemic outbreaks which took place up until the 1940s. As such, the quarantine complex represents one of the most complete collection of buildings, equipment and a setting showing how life was lived among the struggles and successes in public health of Australia's past.