The show centers on FBI special agents Fox Mulder (David Duchovny) and Dana Scully (Gillian Anderson) who work on cases linked to the paranormal, called X-Files. Mulder is later found in the desert following the events of the second season finale and nursed back to health by Albert Hosteen (Floyd Red Crow Westerman). Meanwhile, Scully investigates the possible involvement of the smallpox eradication program in human genetic experimentation, discovering that a Nazi scientist who defected during Operation Paperclip has been conducting human experimentation to create alien-human hybrids. Her sister Melissa (Melinda McGraw), however, is shot by assassins who mistake her for Dana, and dies in hospital that night.