In 1910, at the age of twenty, Sais made her screen debut for New York City's Vitagraph Studios in the short film adaptation of William Shakespeare's "Twelfth Night" opposite the notable actors Florence Turner and Julia Swayne Gordon. Sais would go on to star in a number of well-received comedy shorts for Kalem Company opposite actors Ruth Roland, Marshall Neilan and Edward Coxen. In 1911, Sais made her first appearance in a Western titled "The Ranger's Stratagem" – it would become a frequent career choice for the actress and in her later career she would rarely appear in other motion picture genres.