A total of 110 Manila-Acapulco galleons set sail between 1565 and 1815, during the Philippines trade with Mexico. Until 1593, three or more ships would set sail annually from each port bringing with them the riches of the archipelago to Spain. European "criollos", "mestizos" and Portuguese, French and Mexican descent from the Americas, mostly from Latin America came in contact with the Filipinos. Japanese, Indian and Cambodian Christians who fled from religious persecutions and killing fields also settled in the Philippines during the 17th until the 19th centuries.