Toxic additives used in plastic manufacturing can into their surroundings when exposed to water. Waterborne hydrophobic pollutants collect and magnify on the surface of plastic debris, thus making plastic more deadly in the ocean than it would be on land. Hydrophobic contaminants bioaccumulate in fatty tissues, biomagnifying up the food chain and pressuring apex predators and humans. Some plastic additives disrupt the endocrine system when consumed; others can suppress the immune system or decrease reproductive rates. Bisphenol A (BPA) is a famous example of a plasticizer produced in high volumes for food packing from where it can leach into food, leading to human exposure. As an estrogen and glucocorticoid receptor agonist, BPA is interfering with the endocrine system and is associated with increased fat in rodents.