In near-future 2008, Los Angeles (referred to as "The Southland" by locals) is a dystopian city on the brink of chaos overshadowed by the growth of an underground neo-Marxist organization. The film follows the criss-crossed destinies of Boxer Santaros, an action film actor stricken with amnesia; Krysta Now, a psychic ex-porn star in the midst of creating a reality TV show; and twin brothers Roland and Ronald Taverner, whose destinies become intertwined with that of all mankind. The Taverner twins are revealed to be the same person by the engineers of Treer, duplicated when Roland traveled through a rift in space-time, while Boxer has become the most wanted man in the world despite his political ties and his having the fate of the future, in the form of a prophetic screenplay foretelling the end of the world, in his hands.