In late 2005, Mihos announced that he was thinking of running for governor in 2006. After Romney announced that he would not seek re-election, Mihos decided to pursue his candidacy further. Lieutenant Governor Kerry Healey had won the support of Romney and the majority of the state Republican leadership for the nomination, so Mihos decided to run as an Independent, announcing his candidacy for governor via televised interview on March 2, 2006. The next day, he held a rally at the Massachusetts State House to officially announce his candidacy. An article published on March 21 in "The Boston Globe" drew attention to Mihos's interactions with public university professor Lou DiNatale. DiNatale had involvement in Mihos political campaign, including poll analysis, despite the fact that DiNatale was never employed by Mihos, and the state education system prohibited its educators from being involved in political campaigns. The "Globe" wrote that DiNatale had "an unusual relationship with Christy P. Mihos, now an independent candidate for governor."