After sea trials "Hursley" was commissioned for service on 2 April 1942. She sailed for Scapa Flow for training, and then joined the escort for Russian Convoy PQ 15 to Murmansk and back. Assigned to the Eastern Fleet, in May she joined the escort for Convoy WS 19 to Durban. There she was transferred to the 5th Destroyer Flotilla in the Mediterranean, owing to heavy losses in "Operation Vigorous", and sailed to Alexandria, Egypt, where she was deployed for flotilla duties in eastern Mediterranean.