When Cerebra detected the sudden appearance of six hundred new mutant signatures in Tokyo, Storm sent Colossus and his team of young mutants – composed of Anole, Ernst, Glob, and No-Girl – to investigate, only to learn that the signatures was the work of the Sugar Man who had genetically engineered six hundred mutant embryos in total isolation from the Terrigen Mists and planned to send them to the future, where they would be safe from the M-Pox caused by the Mists and would grow to become the next generation of mutants, with him as their leader. Sugar Man was about to teleport the ark and himself to the future when Colossus and the young X-Men arrived. Their interference resulted in Sugar Man being separated from his ark and their teleportation along the ark to the future. Soon afterwards, the X-Men arrived and, upon discovering what had happened, used Cerebra to track and follow Colossus and his team through the timestream. Arriving a thousand years into Earth's future, the X-Men found themselves in a destroyed New York City. The X-Men soon found their young members, but Colossus wasn't with them anymore, and they were somewhat different as they had arrived some time before Storm's team. They were in possession of the ark containing the mutant embryos and were also protecting it. When the older X-Men asked what had happened to Colossus, Cerebra warned them of the incoming threat: the Horsemen of Apocalypse which was composed of Deadpool, the Venom Symbiote, a female version of Moon Knight and Colossus himself after he had taken the place of Man-Thing.