Is sleep the only thing that matters in this synaptic homeostasis hypothesis? In February 2002, two separate articles were published on the discovery of a receptors' involvement in synaptic homeostasis. Bone morphogenetic proteins, BMPs, were originally found to cause a differentiation in bone formation; however, they have recently been discovered necessary for synaptic regulation. It was noticed that when there were mutations in the BMP type II receptor, more commonly known as wishful thinking or wit for short, the sizes of synaptic clefts were significantly reduced, as well as the synaptic output in the studied species.