"Whipple" departed Norfolk on 26 May 1927 to begin a cruise with her division to northern European ports. She then steamed south for a brief tour in the Mediterranean before departing Gibraltar on 29 January 1928 and heading for Cuba. She conducted operations in the Caribbean out of Guantanamo Bay, until 26 March when she set course for the United States West Coast. She operated in the Pacific out of the Destroyer Base at San Diego, California, until 1 August 1929. "Whipple" departed the U.S. West Coast, bound for the Asiatic Station and her second tour with the Asiatic Fleet.