In 2013, Tagame was approached by editors at the publishing company Futabasha about creating a manga series for general audiences. Though Tagame had previously been approached by mainstream manga magazines about creating a non-pornographic autobiographical manga series, he had declined the offers, stating that he "didn't want to abandon my style and my audience by writing a more mainstream work." Beginning in the early 2010s, Tagame noted that while same-sex marriage was rarely covered in the mainstream Japanese press, the issue generated significant interest among his heterosexual fans when he posted about the topic on his Twitter account. Subsequently, Tagame pitched Futabasha for a series about same-sex marriage and LGBT rights in Japan from the perspective of a straight character; the resulting series was "My Brother's Husband", which was serialized in the "seinen" (manga for young adult men) magazine "Monthly Action" from 2014 to 2017. The series was widely acclaimed, won numerous awards, and was adapted into a live-action television drama that aired on NHK in 2018.