The song's first line is a reference to codeine distillation and the politics of the time: "Johnny's in the basement mixing up the medicine / I'm on the pavement thinkin' about the government". The song also depicts some of the growing conflicts between "straights" or "squares" and the emerging counterculture of the 1960s. The widespread use of recreational drugs and turmoil surrounding the Vietnam War were both starting to take hold of the nation, and Dylan's hyperkinetic lyrics were dense with up-to-the-minute allusions to important emerging elements in the 1960s youth culture. According to rock journalist Andy Gill, "an entire generation recognized the zeitgeist in the verbal whirlwind of 'Subterranean Homesick Blues'."