Sardesai played for Bombay in the Ranji Trophy in 13 seasons, between 1961 and 1973, including 10 finals, and never finished on the losing side. He scored 199 against Rajasthan in the 1967 final. In the semi-final against the same team two years later, he was Mankaded by Kailash Gattani. Sardesai's final first-class match was the famous Ranji Trophy final against Madras in 1972–73, which ended on the first ball of the third day. Sardesai scored over 1,000 first-class runs in three domestic seasons, with a career best of 1,429 runs in 1964–65, which included his highest first-class score of 222, for Associated Cement Company against Indian Starlets in the final of the Moin-ud-Dowlah Gold Cup Tournament.