In several aspects the pathology caused by "P. berghei" in mice differs from malaria caused by "P. falciparum" in humans. In particular, while death from "P. falciparum" malaria in humans is most frequently caused by the accumulation of red blood cells in the blood vessels of the brain, it is unclear to what extent this occurs in mice infected with "P. berghei". Instead, in "P. berghei" infection, mice are found to have an accumulation of immune cells in brain blood vessels. This has led some to question the use of "P. berghei" infections in mice as an appropriate model of cerebral malaria in humans.