For 2011, Guintoli has signed with Liberty Cz Group-backed Liberty Ducati, based in Prague, Czech Republic. His teammate will be WSBK veteran and former Guandalini Ducati/Aprilia rider Jakub Smrz. In 2012, Guintoli achieved his and the team's first win at the third round of the season, in Assen. He will top the podium twice again over the course of the season, first at Silverstone and then in the home-round at Magny Cours. He joined the Aprilia factory team in 2013 as a replacement for Max Biaggi, taking one win and finishing third overall in the Championship behind Tom Sykes and Eugene Laverty. He retained his seat for the 2014 Superbike World Championship season, and started the season on a high note by winning Race 2 in the opening round at Phillip Island. Four more wins will follow during the course of the season, culminating in his championship-winning double win at the closing round in Losail. Guintoli is the first French World Superbike champion since Raymond Roche in 1990. For the 2015 Superbike World Championship season, he joined Pata Honda World Superbike. He finished in front of his young Teammate Michael Van Der Mark in the Championship.