Through northwestern Oklahoma, US-283 passes through very sparsely populated areas and is the main north–south traffic corridor. After passing through Cheyenne, 283 meanders through Black Kettle National Grassland then crosses the Canadian River. It continues north to Arnett where it joins with State Highway 51 west for then turns north again passing through Shattuck and Laverne following part of State Highway 15 along the way. North of Laverne, 283 turns west for to visit the town of Rosston then turns north again to cross the Cimarron River shortly before leaving the state for Kansas.