Following the graduation of starting quarterback Mike Perish, Sanford opted to start redshirt sophomore Matt Adam at quarterback. This ultimately forced ISU to alter the successful offensive game plan from the previous season and install a more rush-oriented offense tailored to Adam's skill set. Despite starting the season 4-2, the Sycamores suffered several devastating injuries that wore away at both the depth and consistency and led to ISU falling to North Dakota State, Illinois State, Northern Iowa, and Western Illinois in consecutive games. The Sycamores concluded their season with a 27-24 victory over Youngstown State to finish 5-6.