In week 13, against the San Francisco 49ers, Edwards suffered a groin injury and did not return for the rest of the game. He was sidelined the following two games as a result of the injury. He returned for the final two games of the season. After a 5–1 start, the Bills missed the playoffs for the 9th straight season after losing 8 of the remaining 10 games. Many onlookers have opined that Edwards' play declined as a result of the concussion from Wilson.