The entirety of modern PA 60 was originally designated as part of US 22 and US 30 in the 1920s. In 1953, US 22 and US 30 were realigned to follow the Penn-Lincoln Parkway West between Robinson Township and Pittsburgh's West End that bypassed Crafton to the south, leaving the former alignment unnumbered and without a name. The lack of a route number affected businesses along the road as they could not give directions and led to a decline in business. The former alignment of US 22 and US 30 through Crafton became PA 60 in January 1956. By 1960, a new highway was constructed between the Orange Belt north of Pittsburgh International Airport near Carnot/Moon Township and the junction of US 22, US 30, and PA 60 in Robinson Township. The new road became part of an extended PA 60 in 1962. At the end of the highway, PA 60 followed the Orange Belt north to Carnot, where it met PA 51.