When the lockout came to an end, Knuble was slotted to play right wing on a line with Simon Gagné and Peter Forsberg, a line which was later nicknamed the "Deuces Wild Line." He responded with his best season as a professional in 2005–06, recording career highs in goals (34), assists (31) and points (65). On pace to duplicate his numbers despite his team's poor season in 2006–07, Knuble's season was nearly cut short after a collision with Rangers forward and former Red Wings teammate Brendan Shanahan. After missing a month of action, he returned to the ice and finished with 24 goals and 30 assists in 64 games and brought his plus-minus rating to +2, Knuble being one of two Flyers (Gagné being the other) to finish with a plus rating for the season.