I-81 continues northeast along the west edge of Hagerstown. The Interstate crosses CSX's Lurgan Subdivision and passes under MD 144 (Washington Street) with no access before reaching a cloverleaf interchange with US 40 (National Pike) (Exit 6). The freeway intersects MD 58 (Cearfoss Pike) at a partial cloverleaf interchange (Exit 7). Immediately to the north, I-81 has a partial interchange with Maugansville Road (Exit 8) featuring a loop exit ramp from southbound I-81 and a straight entrance ramp to the northbound direction. The Interstate curves to the north and crosses Norfolk Southern Railway's Lurgan Branch. The speed limit increases to as the Interstate passes along the eastern edge of Maugansville, where the highway meets Maugans Avenue at a diamond interchange (Exit 9). I-81 meets Showalter Road, which is used to access Hagerstown Regional Airport, at a cloverleaf interchange (Exit 10) as the freeway gently curves around the airport's runway. The Interstate heads northeast to the Pennsylvania state line, on top of which the highway meets PA 163 (Mason Dixon Road) at Exit 1 of the Pennsylvania exit sequence. The southbound exit ramp to and entrance ramp from PA 163 are in Maryland and the northbound ramps are in Pennsylvania.