After moving to Chester, he married Kathrine Hardware on 19 July 1687, after her mother initially objected to the marriage. Kathrine Hardware's parents then moved to Chester and Henry and his wife lived with them. Shortly after the birth of their first child, Kathrine died of smallpox on 14 February 1689, at age 25. He named the infant Kathrine after the mother, but the child died 15 months later. He continued to live with the Hardwares after the death of his wife and continued his ministerial duties.