Pavlyuchenkova opened her 2017 season at the ASB Classic where she was defeated in the opening round by Julia Görges. She then made the quarterfinals in Sydney by claiming excellent victories over Samantha Stosur and defending champion Svetlana Kuznetsova before falling to Eugenie Bouchard in straight sets. Seeded 24th at the Australian Open, Pavlyuchenkova defeated a pair of Russians in Evgeniya Rodina and Natalia Vikhlyantseva to reach the third round where she saw off 11th seed Elina Svitolina in three sets, thus advancing to her maiden second week appearance at the tournament. There, she took down an eighth-seeded Kuznetsova in straight sets to cruise into her fourth overall Grand Slam quarterfinal, her second in as many as six months. With this achievement, Pavlyuchenkova has now made the quarterfinals at each of the four Grand Slams. There, she lost to eventual runner-up Venus Williams in straight sets.