The vibrant trade between the Republic of Venice and the people of North Africa, Egypt, and "the East" brought a large variety of African goods, including coffee, to this leading European port. Venetian merchants introduced coffee-drinking to the wealthy in Venice, charging them heavily for the beverage. In this way, coffee was introduced to the mainland of Europe. In 1591 Venetian botanist-physician Prospero Alpini became the first to publish a description of the coffee plant in Europe. The first European coffee house apart from those in the Ottoman Empire and in Malta was opened in Venice in 1645.