The game's story (narrated by Peter Jason) follows the exploits of a wanted outlaw named Jericho Cross and his employment in an ancient vampire-hunting order known as the Darkwatch. After unwittingly releasing the Darkwatch's greatest enemy, a vampire lord named Lazarus Malkoth, Jericho is conscripted into the Darkwatch as an elite operative. Jericho, however, is slowly turning into a vampire himself, as a result of being bitten by Lazarus. The game outlines either Jericho's struggle for humanity or his descent into darkness, depending on the player's actions.