The Ohio River is a long river in the United States. It is located in the Midwestern and Southern United States, flowing southwesterly from western Pennsylvania south of Lake Erie to its mouth on the Mississippi River at the southern tip of Illinois. It is the third largest river by discharge volume in the United States and the largest tributary by volume of the north-south flowing Mississippi River that divides the eastern from western United States. The river flows through or along the border of six states, and its drainage basin includes parts of 14 states. Through its largest tributary, the Tennessee River, the basin includes several states of the southeastern U.S. It is the source of drinking water for three million people.