Varzi's first race car was a Type 35 Bugatti but he shortly changed to driving an Alfa Romeo, a brand with which he would score many victories during the 1929 Italian racing season. In 1930 Varzi acquired a vehicle from the relatively new Maserati company. He drove it as well as an Alfa Romeo earning his country's racing championship, a feat he would repeat in 1934. One of his big victories came at the prestigious Targa Florio where he upset the favored Louis Chiron. Following his win at the 1933 Tripoli Grand Prix, a race at the time associated with a lottery, Varzi was at the forefront of allegations that the race had been fixed.