After Amaterasu and Susano defeat Orochi to save Kushi, recreating past events, Orochi's spirit floats northward. Amaterasu and Issun embark on a journey across Nippon, first arriving at Ryoshima Coast and Sei-An City, the capital of Nippon. There, they work with the beautiful priestess Rao, the legendary submarine Dragon Kingdom, and the reclusive Queen Himiko to rid the coastline and city of Orochi's influence, including destroying a demonic plague and retrieving a mystical weapon from a sunken trading ship. However, it is revealed that the real Rao was killed before Amaterasu arrived, and the Rao they had been working with was the demonic fox god, Ninetails, who murders Himiko before returning to her fortress on the elusive Oni Island. Amaterasu and Issun eventually find and kill Ninetails, noticing that her spirit, like Orochi's, travels to the icy northern island of Kamui. The two decide to travel northward to find the source of the demons.