Pavlyuchenkova's form mid-season did not improve as she suffered a five-match losing streak after Stuttgart, which includes losses at the French Open and Wimbledon, resulting in her ranking falling out of the top 40 to as low as No. 46, her lowest ranking in more than 10 years. At the Rogers Cup, she scored her first win in more than three months, and her third over a top 10 player in 2019, when she defeated ninth seed Aryna Sabalenka in the first round but then lost to Jeļena Ostapenko. After falling to Zarina Diyas in qualifying at Cincinnati, Pavlyuchenkova scored her first win at the US Open since 2016 by beating Pauline Parmentier in the opening round but then lost to Bertens in straight sets.