On October 18, Edwards suffered another concussion early in the second quarter against the Jets as a result of a hit by Jets linebackers Harris and Pace. He did not return for the rest of the game, and missed the following two games. He returned after the bye week to start against the Tennessee Titans, but continued to struggle, at one point missing a wide-open Terrell Owens and then throwing an interception that was returned for a touchdown. He finished the game completing 18 of 28 passes for 185 yards with a touchdown and an interception, as the Bills were routed to a 41–17 loss.