Entering service in 1941, "Nestor" spent most of her career as a patrol and escort vessel in the Atlantic Ocean, the Mediterranean, and the Far East. In December 1941, the destroyer located and sank the . In June 1942, "Nestor" sailed as part of the Operation Vigorous escort force, protecting a supply convoy to Malta. On the evening of 15 June, the ship was heavily damaged by air attack. Despite attempts to tow the ship to base, "Nestor" was abandoned and scuttled off Crete the next morning. "Nestor" is the only ship of the RAN that never operated in Australian waters.