The C-17 replaced the C-141 Starlifter fleet inherited from Military Airlift Command (MAC). C-141s were retired as C-17s were accepted into the inventory. First seeing operational service in 1965 under the Military Air Transport Service (MATS), the last Starlifters were retired in the early 2000s. By 2004, the C-141 left AMC service with active duty USAF units, being confined to Air Force Reserve and Air National Guard units for the remainder of its operational service life. In 2004, 2005, and 2006, the C-141s assigned to the 445 AW participated in missions to Iraq and Afghanistan, mostly for the medical evacuation of wounded service members. The last eight C-141s were officially retired in 2006.