The Tōkaidō route takes its name from the ancient road connecting the Kansai region (Kyoto, Osaka) with the Kantō region (Tokyo, then Edo) through the Tōkai region (including Nagoya). Literally, it was the Tōkai road, or Road through Tōkai. The Tōkaidō Line does not follow the old road exactly, since the latter diverges at Nagoya toward the Mie Prefecture coastline; to follow it by train, the Kansai Main Line and Kusatsu Line would have to be followed from Nagoya to Kusatsu. The largest population centers in Japan are along this route - Tokyo, Yokohama, Nagoya, Kyoto, Osaka and Kobe. These centers have grown to occupy an ever more dominant role in the country's government, financial, manufacturing and cultural life.