Prior to the 2006–07 season, Self was 72–24 (.750) in three seasons at KU, 279–129 (.683) in 13 seasons overall and 13–8 in NCAA Tournament play. On February 10, 2007, Self recorded his 300th career win in a 92–74 victory at Missouri. Self led Kansas to the 2007 Big 12 regular-season championship with a 14–2 record, highlighted by a win over Kevin Durant-led Texas in a pair of monumental, come-from-behind victories in the last game of the regular season and in the Big 12 Championship game. At the end of the regular season, Kansas stood at 27–4 and ranked #2 in the nation in both the AP and Coaches' polls. In the NCAA Tournament, Self's Jayhawks received a #1 seed, and advanced to Self's fourth career Elite Eight, with the team garnering commanding wins over #16 seeded Niagara and #8 seeded Kentucky, as well as a victory over the #4 seeded Southern Illinois. Kansas's tournament run ended in the Elite Eight with a loss to 2-seed UCLA.