Eddie Guerrero, from the famous Mexican Guerrero wrestling family, achieved huge stardom during this period. He gained a large fanbase in 2003 on "SmackDown!", which lead to a rapid increase in his popularity, promoting him to main event status, and he ultimately won his first world championship, the WWE Championship, at No Way Out in 2004, defeating Brock Lesnar in a highly-acclaimed match. He remained the top wrestler of the company after winning the WWE title until his untimely death on November 13, 2005. He was inducted into the WWE Hall of Fame the following year. Guerrero's death due to his drug addictions caused WWE to implement the WWE Wellness Policy to prevent wrestlers from taking drugs. The circumstances of his death would provide a medium for his on- and off-screen friend Rey Mysterio to emerge as a major main-eventer and win the 2006 Royal Rumble match and the World Heavyweight Championship at WrestleMania 22. Mysterio had begun a rivalry with the villainous nephew of Eddie, Chavo Guerrero Jr., who had cost him the World title during a match with Booker T. During the feud Mysterio injured his knees and would be sidelined for the rest of 2006 and most of 2007, halting his main event push. Mysterio returned and defeated Chavo in the 2007 edition of SummerSlam and remained a popular fan-favorite wrestler.