M-125 starts at the state line as the continuation of Detroit Avenue running northward from Toledo. Once across the state line, the roadway takes on the Dixie Highway name and passes a residential subdivision. The highway runs north-northeasterly roughly parallel with, and between, both US 24 and I-75 through farm land in rural Monroe County. The trunkline passes through the community of Erie before intersecting with Conn. M-125 (Summit Street) north of town. That unsigned connector is a state highway that links M-125 with I-75 to the south. Continuing north, M-125 intersects Luna Pier Road, which to the west is the unsigned Conn. US 24 that offers a path to US 24 (Telegraph Road).