Dettingen's vintners were active during the German Peasants' War of 1525. During the Thirty Years' War the village was badly damaged, its population was reduced by war and plague to around one third. In the early 17th century, the village had around 1300 inhabitants, in 1654 there were just 511. The settlement was slow to recover; the Napoleonic wars of the 17th century dealing it another setback. In 1715, 160 farmsteads were uninhabited and 300 acres of fields and vineyards lay fallow. In 1803, Dettingen had about 1800 inhabitants.