She returned to music in 1975 at the urging of the comedian Redd Foxx, followed by a series of comedic acting jobs. This launched her career in TV, film, and stage. She had a recurring role during the second season of the sitcom "Hello, Larry" as the neighbor, Leona Wilson. She starred as Motormouth Maybelle Stubbs, a friendly and strong-willed record promoter and mother of Seaweed and L'il Inez, in the John Waters cult classic film "Hairspray". On Broadway, she starred in productions of "Amen Corner" and "Black and Blue". The latter earned her a Tony Award for Best Actress in a Musical in 1989. The New York Times theater critic Frank Rich wrote, "Ruth Brown, the rhythm-and-blues chanteuse, applies sarcastic varnish and two-a-day burlesque timing to the ribald Andy Razaf lyrics of 'If I Can't Sell It, I'll Keep Sittin' on It.'"