Scott's fear of typecasting led him to play different types of characters post-"American Pie", such as a hapless nerd in the horror film "Final Destination" (2000) and a friendly stoner in "Dude, Where's My Car?" (2000). "Dude, Where's My Car?" was a box office success and has managed to achieve a cult status. The film earned $73.2 million worldwide against a $13 million budget. He also appeared in films "Road Trip" (2000), "Jay and Silent Bob Strike Back" (2001), "Evolution" (2001), "Stark Raving Mad" (2002) and "Bulletproof Monk" (2003). He played Peppers in "Old School" (2003), which was a moderate box office success and has gained a massive cult following over the years. Scott portrayed Bo Duke in "The Dukes of Hazzard" (2005), which was also financially successful, but received negative reviews from critics. The film eventually collected $111 million worldwide. He was nominated for MTV Movie Award for Best On-Screen Team with Jessica Simpson and Johnny Knoxville for their roles in "The Dukes of Hazzard". Scott hosted the MTV Movie Awards 2003 with Justin Timberlake.Scott landed a lead role as a police officer in "Southland Tales" (2007), where he reunited with Dwayne "The Rock" Johnson, with whom he had previously worked in "The Rundown" (2003). The two performed several skits, including scenes from "The Matrix Reloaded", which are on "The Matrix Reloaded" DVD. He has also hosted "Saturday Night Live" and appeared as a guest co-host on "Live with Regis and Kelly". Scott appeared as John Farley in "Mr. Woodcock" (2007) and as Jeff Nichols in "" (2007). His next film, "Role Models" (2008) was a commercial success and grossed over $92 million at the box office worldwide. The film was met with positive reviews and was selected as one of the best films of 2008 by Eye Weekly.