U.S. Route 50, also known in modern times for most of its mileage in Virginia as the John Mosby Highway and for a part as the Lee-Jackson Highway, is steeped in history as a travelway. Native Americans first created it as they followed seasonally migrating game from the Potomac River to the Shenandoah Valley. As English colonists expanded westward in the late 17th and 18th centuries, the Indian trail gradually became a more clearly defined roadway. First on horseback, and then in stage coaches and wagons, in colonial times, travelers from the ports of Alexandria and Georgetown (then in Maryland) followed it to Winchester at the lower end of the Shenandoah Valley for trade. Along the way, small settlements sprang up which provided lodging and provisions for travelers and trade centers for local farmers.