Gattuso's managerial career began as player-manager of his final club, Sion of the Swiss Super League, and he also had short spells in charge of Palermo and OFI Crete. In June 2016, he led Pisa to Serie B promotion. He later coached both the youth side and the first team of his former club Milan between 2017 and 2019, before being appointed as manager of Napoli later that year, with whom he won his first title as a coach, the 2019–20 Coppa Italia.