Oxford and Lafayette County were formed from lands ceded by the Chickasaw people in the Treaty of Pontotoc Creek in 1832. The county was organized in 1836, and in 1837 three pioneers—John Martin, John Chisom, and John Craig—purchased land from Hoka, a female Chickasaw landowner, as a site for the town. They named it "Oxford", intending to promote it as a center of learning in the Old Southwest. In 1841, the Mississippi legislature selected Oxford as the site of the state university, which opened in 1848.