Best appeared in Harold Pinter's "The Homecoming" at the Cort Theatre in New York, which co-starred Ian McShane, Raúl Esparza and Michael McKean. Daniel Sullivan directed the 20-week limited engagement, which ran until 13 April 2008. She once again appeared as Beatrice in a critically acclaimed production of "Much Ado About Nothing" at Shakespeare's Globe Theatre in 2011, playing opposite Charles Edwards as Benedick and starred in the Old Vic production of The Duchess of Malfi in 2012. She made her directorial debut with a production of Macbeth at Shakespeare's Globe Theatre in 2013.