Machine Man appears twice in the "Marvel Zombies" universe, initially in a cameo as part of the Nextwave team who engage in battle against the infected heroes and are killed off panel in "Marvel Zombies vs. The Army of Darkness", and as the main character in "Marvel Zombies 3". As the main character, Machine Man accepts an assignment on behalf of A.R.M.O.R. to accompany Jocasta to retrieve a blood sample from a living human from the "Marvel Zombies" universe, and the two are transported there by Portal. At first he wants to complete his mission only for the money, until he discovers that the zombies are cloning humans for food, much as humans use his fellow robots only for their own needs. He obtains cell samples from the Kingpin's wife Vanessa, who is still alive and being kept safe by the Kingpin. Machine Man delivers the samples to Jocasta, but the zombies nearly destroy him in retribution, and Portal and Jocasta are forced to leave his ruined body in that dimension. After Machine Man reveals that it was a holographic projection of himself, he fights off some zombies and captures the zombie Lockjaw who he uses to teleport back to his own dimension. Disposing of the remaining zombies within the facility, Machine Man and Jocasta are assigned back to S.H.I.E.L.D.