The first of these, philosopher and physician Francisco Sanches, was led by his medical training at Rome, 1571–73, to search for a true method of knowing ("modus sciendi"), as nothing clear can be known by the methods of Aristotle and his followers — for example, 1) syllogism fails upon circular reasoning; 2) Aristotle's modal logic was not stated clearly enough for use in medieval times, and remains a research problem to this day. Following the physician Galen's "method of medicine", Sanches lists the methods of judgement and experience, which are faulty in the wrong hands, and we are left with the bleak statement "That Nothing is Known" (1581, in Latin "Quod Nihil Scitur"). This challenge was taken up by René Descartes in the next generation (1637), but at the least, Sanches warns us that we ought to refrain from the methods, summaries, and commentaries on Aristotle, if we seek scientific knowledge. In this, he is echoed by Francis Bacon who was influenced by another prominent exponent of skepticism, Montaigne; Sanches cites the humanist Juan Luis Vives who sought a better educational system, as well as a statement of human rights as a pathway for improvement of the lot of the poor.