Equine influenza (horse flu) is the disease caused by strains of influenza A that are enzootic in horse species. Equine influenza occurs globally, previously caused by two main strains of virus: equine-1 (H7N7) and equine-2 (H3N8). The OIE now considers H7N7 strains likely to be extinct since these strains have not been isolated for over 20 years. Predominant international circulating H3N8 strains are Florida sublineage of the American lineage; clade 1 predominates in the Americas and clade 2 in Europe. (Elton and Cullinane, 2013; Paillot, 2014; Slater et al., 2013). The disease has a nearly 100% infection rate in an unvaccinated horse population with no prior exposure to the virus.