"Mujhse Dosti Karoge!" opened to mixed reviews; critics were appreciative of the leads but criticized its "predictable" plot. Writing for Bollywood Hungama, Taran Adarsh gave the film a rating of one star, noting that it "clearly belongs to Rani Mukherji, who has the meatiest role comparatively". He believed that Mukerji was "superb in a role that fits her like a glove", but thought that Kareena Kapoor was "relegated to the background completely". In a two-and-a-half-star review, Subhash K. Jha saw that "Kohli tries hard to bring in his own touch to the Chopra-esque ambience". Derek Elley of "Variety" said that Kapoor "largely reprises her pampered bimbo" from "Kabhi Khushi Kabhie Gham..." (2001), and praised Roshan for "proves a smart mover and good dance talent". Manish Gajjar of the BBC shared similar thoughts of Kapoor: [She as Tina looks ravishingly beautiful and shows great flair for comedy in this film. Although the audience will be reminded of her Poo character from the hit film "Kabhie Khushi Kabhi Gham..."."