The other major problem was the purity of the uranium. Impurities could act as neutron poisons and prevent a nuclear reactor from working, but the uranium oxide that Fermi wanted for his experimental reactor contained unacceptably large amounts of impurities. As a result, references published before 1942 typically listed its melting point at around when pure uranium metal actually melts at . The most effective way to purify uranium oxide in the laboratory was to take advantage of the fact that uranium nitrate is soluble in ether. Scaling this process up for industrial production was a dangerous proposition; ether was explosive, and a factory using large quantities was likely to blow up or burn down. Compton and Spedding turned to Mallinckrodt in Saint Louis, Missouri, which had experience with ether. Spedding went over the details with Mallinckrodt's chemical engineers, Henry V. Farr and John R. Ruhoff, on 17 April 1942. Within a few months, sixty tons of highly pure uranium oxide was produced.