Bolstered by Blues Traveler's mainstream success, Popper released a solo album, "Zygote", in 1999 and toured in support of it with his own John Popper Band. The album was produced by Terry Manning, and the backing band consisted of longtime friends Dave Ares, Crugie Riccio, and Rob Clores of Cycomotogoat, with drummer Carter Beauford of Dave Matthews Band. The album's release came less than three months after his heart surgery, and only days after the death of Bobby Sheehan, Popper's bandmate and best friend. The subsequent tour was canceled midway due to poor ticket sales, and Popper instead took the time to focus on his health.