Originally known as Pityusa or Pityussa (), it was colonized from Phocaea and Miletus. In the 6th century BC Lampsacus was attacked by Miltiades the Elder and Stesagoras, the Athenian tyrants of the nearby Thracian Chersonese. During the 6th and 5th centuries BC, Lampsacus was successively dominated by Lydia, Persia, Athens, and Sparta. The Greek tyrants Hippoclus and later his son Acantides ruled under Darius I. Artaxerxes I assigned it to Themistocles with the expectation that the city supply the Persian king with its famous wine. When Lampsacus joined the Delian League after the battle of Mycale (479 BC), it paid a tribute of twelve talents, a testimony to its wealth; it had a gold coinage in the 4th century, an activity only available to the more prosperous cities.