On 10 March 2019, Molinari won the Arnold Palmer Invitational for his third PGA Tour victory of his career. He teed off 10 groups ahead of the leaders on the final day and 5 stokes behind, making three birdies and no bogeys on his first seven holes. On the 8th hole, from well off the green he holed a chip for another birdie and made the turn in 32 (−4). He made four more birdies on the back nine, including a 43-foot putt at the 72nd hole, to shoot a final-round 64 that ended up giving him a two-stroke win over Matthew Fitzpatrick, who shot a final-round 71.