The orientation of the line, running south-west to north-east, is a clue to the origin of Denton Station; it stands on the former mainline of the London & North Western Railway between Crewe and Leeds via Stockport. The London & North Western Railway had already completed its line to Manchester via Stockport and now looked to expand to reach the woollen districts of the West Riding of Yorkshire, building quadruple tracks all the way to Huddersfield and Leeds via the Standedge tunnel.