The 2018 season started slow for Keselowski, as he failed to win at the first 24 races. He then won back-to-back races at Darlington and Indianapolis, giving Team Penske its first victory in the Brickyard 400, which was a highly coveted win for Team Penske given their history at the Indianapolis Motor Speedway and the Indy 500. Keselowski backed up his Playoff run with a win at Las Vegas, giving Roger Penske his 500th overall motorsports victory as a car owner and advancing him to the Round of 12, despite surviving a hard crash at the Charlotte Roval. Keselowski was eliminated from the Round of 12 after the fall Kansas race and finished the season eighth in the points standings.