Biandrate fled, but conspiring at a distance, returned once more in 1216 to claim the Regency. "In response to Queen Margaret's appeal the Emperor hurried to her assistance, but arrived on the scene only to die with mysterious suddenness in the flower of his age." About 1216 Margaret fled to Hungary apparently leaving her son Demetrius in Thessalonica. She married thirdly Nicholas I of Saint Omer, who had accompanied his uncle on the Crusade and was granted a fief in Doris. He is also called "Lord of Boeotia".