Upon entering the refuge, the highway curves around to the southwest. SH-49 passes in between Big Four Mountain (elev. ) and Sunset Peak. The road then drops down to Antelope Flat, where it crosses the stream that feeds Caddo Lake, as well as passing near the lake itself. It serves as the northern terminus of Indiahoma Road, which heads south towards French Lake, the trailhead of the Dog Run Hollow hiking trail, and many of the peaks in the southwest part of the refuge, before eventually serving the town of Indiahoma south of the refuge. After the Indiahoma Road intersection, it crosses the stream that forms French Lake. At the Boulder Turnoff, it intersects the road leading to Lost Lake and Eagle Mountain. The road then curves northeast to bypass Quanah Parker Lake and its campsite. The road then curves due south towards the Cache Wye.