Calhoun soon became politically estranged from President Jackson, due in part to an 1830 letter written by Crawford stating that Calhoun, as Secretary of War under President James Monroe, pushed for a reprimand of then-General Jackson for his actions in the 1818 invasion of Florida. The Petticoat affair in which Calhoun's wife, Floride, was a central figure further alienated Jackson from the vice president and his supporters. The final blow to the relationship came in January 1832, when Calhoun, as President of the Senate, sank Van Buren's nomination as Minister to Great Britain by casting a tie-breaking vote in the United States Senate. Consequently, Calhoun was replaced as the party's 1832 vice presidential nominee by Van Buren. Later that year, on December 28, he resigned as Vice President, after having been elected to the U.S. Senate. There he continued to be a proponent of the doctrine of nullification in opposition to Jackson.