Keselowski started the 2019 season with a 12th-place finish at the Daytona 500. A week later, he won at Atlanta; this gave him his 60th overall win with Team Penske and the first MENCS win for the new Ford Mustang GT. Keselowski followed this up with wins at Martinsville and Kansas. Keselowski dominated the early stages of the Coke 600, but spun out with 5 to go, finishing 19th. He finished fifth at the Charlotte Roval to advance to the Round of 12. For the second season in a row, Keselowski was eliminated in the Round of 12 after the Kansas race.