On 10 September 2011, Gamboa fought "Ring" top 10 ranked featherweight Daniel Ponce de León in a non-title fight. Gamboa managed to connect more punches in every round to keep the scorecards in his favor. Although there were not many exchanges, Gamboa's hand speed and reflexes were on display as he connected with quick and short combinations and managed to avoid some of de León's left swings with his characteristic upper body movement. In the eighth round, during a short exchange, Gamboa and de León accidentally clashed heads, resulting in de León suffering a cut to his forehead, consequently the referee stopped the fight and asked de León's corner to check the boxer's wound. After having tried and failed to stop the bleeding it was determined by de León's team that their fighter was unable to continue in the fight.