Four years later, when Seoul, South Korea hosted the 1988 Summer Olympics, she swam the freestyle leg for the silver medal-winning U.S. team in the women's 4×100-meter medley relay with teammates Beth Barr (backstroke), Tracey McFarlane (breaststroke), and Janel Jorgensen (butterfly). The U.S. women's medley relay team was fraught with last-minute drama, as several previously selected swimmers dropped out to focus on individual events, or were replaced because they had performed below expectations, only hours before the event final. In the event final, the U.S. medley relay team included women with no history of competing together, no relay exchange practice, and no coach; the East German favorites taunted the Americans before the race. Wayte would later characterize the race as one of her proudest moments. She also captured a bronze medal with the third-place U.S. women's 4×100-meter freestyle relay team that included Mitzi Kremer, Dara Torres and Laura Walker. Individually, she finished fourth in the women's 200-meter freestyle; she was also a medal contender in the women's 200-meter individual medley, but was disqualified when the judges ruled she used an illegal butterfly kick on the breaststroke leg of the medley.