On March 9, 1897, Sockalexis signed a major league contract with the Cleveland Spiders. Just a month later, on April 22, Sockalexis made his major league debut. Just a few months after he was expelled from school, his drinking problems resurfaced. On July 4, 1897, Sockalexis, in an inebriated condition, jumped from the second-story window of a brothel. He severely injured his ankle in the fall. Evidently, the injury affected his play. In the five games after the injury, he had nine hits in 18 at bats. However, his fielding was not very good. From July 25 until September 12, Sockalexis played in just one game. In that game, he committed two errors. In his first season with the Spiders, Sockalexis hit for a .338 batting average with three home runs and 42 RBIs. In 66 games that season, Sockalexis also had 16 stolen bases.