Molinari gained an automatic selection for the 2012 Ryder Cup, where he played the foursomes with Lee Westwood on Friday, losing by 3 and 2 to Jason Dufner and Zach Johnson; he then teamed up in the four-balls with Justin Rose, losing by 5 and 4 against Bubba Watson and Webb Simpson. On the final day, he halved with Tiger Woods in the last singles match. The point meant Europe not only completed a comeback from 10–6 down at the start of the final day to retain the cup, but won it outright by a score of 14½ points to 13½.