In 2015 and 2016 Molinari shared his time between the European Tour and PGA Tour. In September 2016 he became the first Italian to win his national open twice with a 1 shot victory over Danny Willett at the 2016 Italian Open. Other notable results in Europe were the 2nd places collected at the 2015 Open de España and 2016 Open de France, while in the U.S. he collected a 3rd place at the 2015 Memorial Tournament. In the same year he also recorded a hole in one at the iconic 16th hole of the Waste Management Phoenix Open.