Pennsylvania Route 272 (PA 272) is a highway in eastern Pennsylvania, in the Lancaster area. The southern terminus of the route is at the Mason–Dixon line southeast of Nottingham, where it continues into Maryland as Maryland Route 272 (MD 272). The northern terminus is at an interchange with U.S. Route 222 (US 222) and PA 568 in Adamstown, where PA 568 continues east. The route heads from the Maryland border northwest through the western corner of Chester County, intersecting US 1 in Nottingham. PA 272 continues west into Lancaster County and intersects US 222 in Wakefield, where it turns north and passes through Buck before widening into a divided highway as it comes to another junction with US 222 in Willow Street. Here, the route becomes unsigned and follow US 222 north through Lancaster along one-way city streets. North of Lancaster, US 222 splits at an interchange with US 30 and PA 272 becomes signed again, heading northeast parallel to the freeway alignment of US 222 and passing through Akron, Ephrata (where it intersects US 322), and Adamstown. The route enters Berks County and comes to its northern terminus.