After a career-high 37-goal, 69-point campaign in 2006–07, the Sabres made a second consecutive run to the Eastern Conference Finals this time as the Presidents' Trophy-winning first seed, where they faced the Ottawa Senators. Proving he could still be a clutch performer, Drury scored two game-winning goals in the first round against the New York Islanders, then scored the game-tying goal in game five of the second round against the New York Rangers with 7.7 seconds left in regulation time. The Sabres won 2–1 in overtime and closed out the series against the Rangers, four games to two. In Game 4 of the Conference Finals against the Senators, Drury recorded another game-winner to stave off elimination, though the Sabres were eventually defeated four games to one.