In her first World Cup races in the 2005–06 season, Neuner achieved average course times; her best result was being fourth fastest in the pursuit race in Kontiolahti. During her first full season in 2006–07, she finished among the top three fastest skiers in 19 of her 24 races and came in fastest in seven of them. Neuner won the 2007–08 Biathlon World Cup with dominating skiing performances. She set the fastest course time in 19 of her 25 races and was second or third fastest in the remaining six. At the beginning of the 2008–09 season, Neuner had a substantial drop in her skiing times due to a series of illnesses. However, she recovered and set the fastest course time in 14 of the remaining 18 races from January onwards. In the 2009–10 Olympic season, Neuner again started slowly in December, but came back finishing among the top three fastest skiers in 17 of her 21 races. She had her second best winter in 2010–11 when she set the fastest or second fastest skiing time in 90% of her 21 races.