Modern glass knives were once the blade of choice for the ultra-thin sectioning required in transmission electron microscopy because they can be manufactured by hand and are sharper than softer metal blades because the crystalline structure of metals makes it impossible to obtain a continuous sharp edge. The advent of diamond knives, which keep their edge much longer and are more suitable for cutting hard materials, quickly relegated glass knives to a second-rate status. However, some labs still use glass knives because they are significantly less expensive than diamond knives. A common practice is to use a glass knife to cut the block which contains the sample to near the location of the specimen to be examined. Then the glass knife is replaced by a diamond blade for the actual ultrathin sectioning. This extends the life of the diamond blade which is used only when its superior performance is critical.