Vos was a frequent guest on the "Opie and Anthony" radio show, with jokes centered at his expense, most often highlighting his speech impediment or supposed lack of intellect. In 2002, he was responsible for having fellow comedian Patrice O'Neal come on the show, who also became a popular regular guest. When the show aired on SiriusXM Radio, Vos hosted a Saturday night program with his wife Bonnie McFarlane. He hosted the 2006 and 2007 editions of the Opie and Anthony's Traveling Virus Comedy Tour.