The Uzbeks' struggle with Iran also led to the cultural isolation of Central Asia from the rest of the Islamic world. In addition to these problems, the struggle with the nomads from the northern steppe continued. In the 17th and 18th centuries, Kazakh nomads and Mongols continually raided the Uzbek khanates, causing widespread damage and disruption. In the beginning of the 18th century, the Khanate of Bukhara lost the fertile Fergana region, and a new Uzbek khanate was formed in Quqon.