The main branch of the Sheshequin Path followed Lycoming Creek north past the modern villages of Hepburnville, Cogan Station and Trout Run (the modern path of U.S. Route 15 and the future Interstate 99). From Trout Run it continues past Fields Station, Bodines, Marsh Hill, Ralston to the source of Lycoming Creek in the southwest corner of Bradford County. There the path traversed a swampy area for a short distance to the source of Towanda Creek near Grover, following Towanda Creek northeast to modern Canton (this is the route of Pennsylvania Route 14) and on to the village of East Canton. A short cut left the creek between Grover and East Canton. From East Canton the path followed the creek past Leroy, West Franklin, Powell, and Monroeton to the creek's mouth at modern Towanda on the North Branch Susuquehanna River. The path then followed the river north to Sheshequin (and from there north to modern New York and the Iroquois there). The alternate branch known as St. Joseph's Path left Towanda Creek at Powell, and ran north to Sugar Creek, which it either followed to the river and the village of Oscalui then north to Sheshequin, or crossed to go on to Sheshequin. Pennsylvania Route 414 follows the path from Canton to Monroeton, and U.S. Route 220 follows it to Towanda and north along the river to Sheshequin.