Disston "recreationed" in politics, starting as early as 1876 in local issues. He and three other industrialists in Philadelphia—James McManes, William Leeds, and David Lane— were known as the "Big Four", controlling Republican nominations and appointments to city positions in a machine system until new political bosses replaced them in 1890. His wealth allowed him to associate with tycoons and political celebrities, and he was often sought after to advise politicians though he refused to run for office. He publicly supported future president Benjamin Harrison, Congressman William D. Kelley, and political boss Matthew Quay.