When indeterminancy problems arose because the brain is physically isomorphic to multiple structures of the external world, it was urged that we use a pragmatic approach to resolve the problem. Another approach argues that we should use the pragmatic theory of truth from the beginning to decide whether certain neural circuits store true information about the external world. Pragmatism was founded by Charles Sanders Peirce, John Dewey, and William James. Pragmatism was later refined by our understanding of the philosophy of science. According to pragmatism, to say that General Relativity is true is to say that the theory makes more accurate predictions about world events compared to other theories (Newtonian mechanics, Aristotle's physics, etc.). Thus within pragmatism, in what sense can we say that information in brain-A is true while that does not hold about information in brain-B regarding the external world. Assume computer circuits lack intentionality and do not store information using propositions, then in what sense can we say that computer-A has true information while computer-B lacks true information about the external world. If the computers were instantiated in autonomous cars, we can test whether computer-A or computer-B successfully completed a cross-country road trip. For instance, if computer-A succeeded at the task while computer-B failed, the pragmatist can say that computer-A holds true information about the external world. The reason is that the information in computer-A allows it to make more accurate predictions (relative to computer-B) about the external world and helps it successfully move around in the environment. Similarly, if brain-A has information that enables the biological organism to make more accurate predictions about the external world and helps the biological organism successfully move around in the environment then we can say that brain-A has true information about the external world (relative to brain-B). Although not advocates of eliminativism, John Shook and Tibor Solymosi argue that pragmatism is a promising program for understanding advancements in neuroscience and integrating that into a philosophical picture of the world.