The tissue, animal model, and animal and human genetic studies cited above implicate ALOX5 in a wide range of diseases: a) excessive inflammatory responses to pathogens, trauma, burns, and other forms of tissue injury [see Inflammation#Causes); b) chronic inflammatory conditions such as rheumatoid arthritis, atherosclerosis, inflammatory bowel disease, autoimmune diseases, and Alzheimer's disease (see Inflammation#Inflammatory disorders); c) allergy and allergic inflammation reactions such as allergic rhinitis, conjunctivitis, asthma, rashes, and eczema; d) NSAID-induced acute non-allergic reactions such as asthma, rhinitis, conjunctivitis, angioedema and urticaria; and e) the progression of certain cancers such as those of the prostate and pancreas. However, clinical use of drugs that inhibit ALOX5 to treat any of these diseases has been successful with only Zileuton along with its controlled released preparation, Zileuton CR.