"Cheating Cheaters " with John Barrymore in 1916. She also debuted in the Broadway theatre in "Yes or No" in 1918. In addition, Main returned to vaudeville to perform at the Palace Theater in a skit called "The Family Ford" with comedian W. C. Fields. Not all of the early plays in which she appeared were a success. "A House Divided" closed in 1923 after just one performance, but Main continued to find work on the Broadway stage. In 1927 she played Mae West's mother in "The Wicked Age", and in 1928 played opposite Barbara Stanwyck in the long-running stage hit "Burlesque". Main also appeared in several other Broadway productions: "Salvation" in 1928, "Scarlet Sister Mary" in 1930, "Ebb Tide" in 1931, "Music in the Air" in 1932, and in "Jackson White".