MS 145 continues northeast through rural areas for several miles, where it passes just west of Wheeler and have an intersection with MS 362, to have an interchange with MS 30 and enter Booneville. It becomes 2nd Street as it widens to four-lane undivided highway and passes through neighborhoods and straight through downtown. The highway then passes through a business district, where it has an intersection with MS 4, before crossing a creek and narrowing to two-lanes to leave Booneville and pass through rural areas before coming to an end at another intersection with US 45.