Brain scans of "superior memorizers", 90% of whom use the method of loci technique, have shown that it involves activation of regions of the brain involved in spatial awareness, such as the medial parietal cortex, retrosplenial cortex, and the right posterior hippocampus. The medial parietal cortex is most associated with encoding and retrieving of information. Patients who have medial parietal cortex damage have trouble linking landmarks with certain locations; many of these patients are unable to give or follow directions and often get lost. The retrosplenial cortex is also linked to memory and navigation. In one study on the effects of selective granular retrosplenial cortex lesions in rats, the researcher found that damage to the retrosplenial cortex led to impaired spatial learning abilities. Rats with damage to this area failed to recall which areas of the maze they had already visited, rarely explored different arms of the maze, almost never recalled the maze in future trials, and took longer to reach the end of the maze, as compared to rats with a fully working retrosplenial cortex.