Hoffman played the lead role in "Outbreak" (1995), alongside Rene Russo, Kevin Spacey, Morgan Freeman, Cuba Gooding Jr. and Donald Sutherland. In the film, Hoffman is a medical doctor who uncovers a newly discovered Ebola-like virus which came to the U.S. from Africa in an infected monkey. Hoffman races to stop the virus's spread and find a vaccine before it becomes a worldwide pandemic with no cure. It was one of the films that was produced by his production banner, Punch Productions.