The city is served by Interstates 81 and 381, and by U.S. Routes 11, 19, 58, and 421. I-81 leads northeast to Roanoke, Virginia, and southwest to Knoxville, Tennessee. Interstate 381 (I-381) is a spur from Interstate 81 that provides access to Bristol, Virginia, United States. It runs for from the intersection of Commonwealth Avenue (State Route 381) and Keys/Church Streets in Bristol at exit 0 north to Interstate 81. The I-81 interchange, the only one on I-381, is signed as exits 1A (I-81 north) and 1B (I-81 south). US 11 and US 19, running parallel to I-81, lead northeast to Abingdon, Virginia. US 11 splits into routes 11W and 11E in Bristol; US 11W leads west-southwest to Kingsport, Tennessee, while US 11E and US 19 lead south-southwest to Johnson City, Tennessee. US 58 runs with I-81 northeast for before splitting off to the east just beyond Abingdon; US 58 and 421 together lead west to Weber City, Virginia. US 421 leads southeast to Mountain City, Tennessee.