In March 2010, Villegas earned his third victory on the PGA Tour, winning The Honda Classic by five strokes over Anthony Kim. He chose not to maintain his status on the European Tour, and a slump in form in 2012 meant he had to enter the PGA Tour's Qualifying School at the end of the season; he finished 144th on the money list. Villegas did not regain a Tour Card but had conditional status on the PGA Tour for 2013, playing in the 126-150 category. His status gave him entry based on sponsor exemptions, past championships, and priority ranking. He regained full privileges for 2014 with a 110th-place finish in the FedEx Cup. In 2014, Villegas won the Wyndham Championship, his first win on Tour in more than four years. The win moved him into the 37th position of the 2014 FedEX Cup prior to going into the FedEx Cup playoffs. With this victory, Villegas earns an invitation into the 2015 Masters Tournament and two years full-exempt status on the PGA Tour.