Irvin was selected by the Dallas Cowboys with the 11th selection in the first round of the 1988 NFL Draft. He was the last first-round draft pick made by the Cowboys under the leadership of long-time general manager Tex Schramm, player personnel director Gil Brandt, and coach Tom Landry (Schramm predicted that Irvin would accelerate the Cowboys' "return to the living"). Irvin became the first rookie receiver in Cowboys' history to start a season opener in 20 years, in which he caught his first career touchdown. He also caught 3 touchdown passes in the Cowboys' win over the Washington Redskins, one of only three wins that season and the final one of Landry's career. He finished the season leading the NFC with a 20.4 yards per catch average.