Differentiation has applications in nearly all quantitative disciplines. In physics, the derivative of the displacement of a moving body with respect to time is the velocity of the body, and the derivative of the velocity with respect to time is acceleration. The derivative of the momentum of a body with respect to time equals the force applied to the body; rearranging this derivative statement leads to the famous equation associated with Newton's second law of motion. The reaction rate of a chemical reaction is a derivative. In operations research, derivatives determine the most efficient ways to transport materials and design factories.