Starting off the 2010 campaign as the Opening Day Starter once again, Sugiuchi recorded a quality start against the Hokkaido Nippon Ham Fighters and got the win over Nippon Ham super-ace, Yu Darvish. Sugiuchi continued his winning ways, but was not as dominant as he had been in the past. Always a bit of a slow starter, he put together a fairly good April, recording a complete-game shutout of the Fighters on the 9th, and he also struck out at least nine batters in all of his starts during the month. However, in his first and last starts of the month, Sugiuchi gave up five runs. Despite having a rough start on May 16, an interleague game against the Tokyo Yakult Swallows, he still remained undefeated in the month, running his record to 13–0 since '07.