"Zombiepowder." is set in a western-themed environment with inconsistent levels of technology, similar to that found in Yasuhiro Nightow's manga series, "Trigun". The most prominent characters in the series are powder hunters, individuals who seek the titular zombie powder. The zombie powder is a life-giving substance that can imbue an individual with limitless life force, grant them immortality, and even raise people from the dead. Zombie powder can only be obtained from the Rings of the Dead. These rings are dangerous magical artifacts that, individually, devour the life force of anyone they touch, rendering them comatose. This stolen life energy is converted into the zombie powder, which can only be extracted if twelve Rings of the Dead are brought together.