"Mujhse Dosti Karoge!" marked Kunal Kohli's directorial debut. The media reported that the film was based on the 1996 American comedy "The Truth About Cats & Dogs", but Kohli explained that "not one scene from it is the same. There is a track dealing with mistaken identity, but it isn't a rip-off." It was produced by Yash Chopra under the banner of Yash Raj Films, and Aditya Chopra co-wrote the story and screenplay with Kohli. The dialogue was written by Kohli. Neil Nitin Mukesh served as the assistant director.