By late 1928, a large renumbering of highways had been carried out. The new SR 5 stretched from Mobile to Tennessee via Birmingham and Florence, and included several former routes: most of SR 6, all of SR 35, most of SR 43, part of SR 5, and all of SR 50. The remainders of SR 35 and SR 43 became parts of SR 22 and SR 18. The old SR 5 was split among several routes. The two halves of the new SR 5 were linked between somewhere near Woodstock and Jasper by a concurrency with SR 7 (US 11) and SR 4 (US 78) via Birmingham. US 43 was added to the route south of Thomasville and north of Phil Campbell in 1933 or 1934. In between those two, SR 5 used a shorter route, mainly SR 13.