Perry had similar numbers in 1968: he posted a 16–15 record, but with a then-career-best 2.45 ERA on a Giants team that finished second to the St. Louis Cardinals. On September 17 of that year, two days after his 30th birthday, Perry no-hit the Cardinals and Bob Gibson 1–0 at Candlestick Park. The lone run came on a first-inning home run by light-hitting Ron Hunt—the second of the only two he would hit that season. The very next day, the Cardinals returned the favor on the Giants on a 2–0 no-hitter by Ray Washburn—the first time in Major League history that back-to-back no-hitters had been pitched in the same series.