Edwards began his rookie season as Cleveland's third wide receiver – a hold-out caused him to miss the beginning of training camp. Early in the season Edwards revealed that he had a staph infection, and missed a few weeks as a result of it. He moved into the starting lineup by midseason. He made his NFL debut versus the Cincinnati Bengals on September 11 and caught his first NFL touchdown at the Green Bay Packers on September 18. He amassed 512 receiving yards and three touchdowns before suffering a season ending knee injury. Edwards had surgery in the offseason, and, while rehabilitating, bonded with Kellen Winslow II. Both were determined to make a full and speedy recovery.