Karygiannis played a prominent role in organizing Toronto-area support for victims of the December 2004 earthquake in Southeast Asia. He called for cooperation between the city's Tamil and Sinhalese communities for the relief effort in Sri Lanka, and personally travelled to Sri Lanka to witness the tsunami devastation firsthand. He was later criticized by fellow Member of Parliament David Kilgour for traveling to an area of Sri Lanka dominated by the Liberation Tigers of Tamil Eelam (Tamil Tigers), as the faction was proscribed as a terrorist organisation by many countries. Karygiannis defended his decision, saying that his intent was to confirm that disaster aid was reaching the region. Despite Kilgour's concerns, Karygiannis's travels did not provoke a diplomatic incident with Sri Lanka.