In May 2006, Molinari claimed his first European Tour victory, becoming the first Italian since Massimo Mannelli in 1980 to win the Telecom Italia Open. This victory helped him finish 38th on the Order of Merit. Molinari didn't win on Tour between 2007 and 2009 but during that time he recorded twenty top-10 finishes including three runner-up finishes. He finished 60th on the Order of Merit in 2007, 24th in 2008 and 14th in the Race to Dubai in 2009. In October 2009, Molinari reached the top 50 of the Official World Golf Ranking for the first time.