In 2004, Panek and his co-workers reported an approach which takes advantage of chiral crotylsilane-based C-C bond construction methodology to obtain the absolute stereochemistry of the three subunits of (+)-discodermolide. One of the key features of the Paterson approach is the utilization of hydrozirconation-cross-coupling methodology for the construction of C13-C14 (Z)-olefin. Acetate aldol reaction with high levels of 1,5-anti stereo induction and palladium-mediated sp2-sp3 cross coupling reaction are used to connect subunits. The Panek synthesis of (+)-discodermolide has an overall yield of 2.1% with a longest linear sequence of 27 steps and 42 total steps.