"The Best Little Whorehouse in Texas" opened on Broadway at the 46th Street Theatre on June 19, 1978, and ran for 1,584 performances. The production was directed by Peter Masterson and Tommy Tune and choreographed by Tune and Thommie Walsh. The opening cast included Carlin Glynn, Henderson Forsythe, Jay Garner, Joan Ellis, Delores Hall, and Pamela Blair. Glynn was replaced by Fannie Flagg and Anita Morris later in the run. Alexis Smith starred as Miss Mona in the first U.S. National Tour, September 1979 through February 1981, with stops in major cities from Boston to Los Angeles.