New York State Route 220 (NY 220) is a state highway located in Chenango County, New York, in the United States. It is signed as an east–west highway, but its actual routing wanders considerably from north to south as it proceeds across the county. The western terminus of NY 220 is at an intersection with NY 41 near the western county line in the town of Smithville. Its eastern terminus is in the town of Oxford, where it becomes County Route 32 (CR 32) east of the village of Oxford. The stub of NY 220 east of Oxford serves as a signed connection between NY 12 and the New York State Veterans' Home at Oxford located east of the village along the Chenango River.