The route fully enters Ephrata Township and narrows to a two-lane road as it runs through a mix of farmland and commercial development, passing over an East Penn Railroad line. The road crosses into East Cocalico Township and continues through agricultural areas with some homes and businesses, again crossing Cocalico Creek. PA 272 passes through the residential community of Reamstown, where it turns to the east. The route curves northeast past commercial development and comes to an intersection with Colonel Howard Boulevard, which heads east to provide access to the US 222 freeway and the Pennsylvania Turnpike (Interstate 76) at the Reading interchange. A short distance later, the road comes to a bridge over the Pennsylvania Turnpike. PA 272 gains a center left-turn lane and continues past businesses, eventually narrowing back to two lanes. The road passes more commercial development with some homes and crosses PA 897 in the community of Swartzville. Past this intersection, the route continues through developed areas and enters the borough of Adamstown. PA 272 heads through wooded areas with some homes and businesses as it passes through the borough. After leaving Adamstown, the road runs through a small corner of Brecknock Township. PA 272 enters Brecknock Township in Berks County and passes commercial development before it comes to its northern terminus at an interchange with the US 222 freeway. A park and ride lot is located at the southwest corner of this interchange. Past this interchange, the road continues east as PA 568.