Aparicio was the team leader when the "Go-Go" White Sox won the American League pennant in 1959, finishing the regular season five games ahead of the Cleveland Indians. Aparicio finished the runner-up to team-mate Nellie Fox in the American League Most Valuable Player Award balloting. He was selected as a starting All-Star for the second time and also won a second Gold Glove award. He posted a .308 batting average in the 1959 World Series as the White Sox were defeated by the Los Angeles Dodgers in a six-game series. When Aparicio stole 50 bases in his first 61 attempts in 1959, the term "Aparicio double" was coined to represent a walk and a stolen base. Following the death of teammate Johnny Romano, Aparicio became the last surviving player to play with the White Sox in the 1959 World Series.