US 113 begins at the city limit of Pocomoke City at an intersection with US 13 (Ocean Highway), the main highway of the Delmarva Peninsula that connects Wilmington and Dover with Salisbury and Norfolk. Old Virginia Road (unsigned MD 250A) continues west to US 13 Business (Market Street). US 13 Business heads north through the Pocomoke City Historic District, which preserves buildings from Pocomoke City's late 19th century and early 20th century heyday as a river port and station on the main rail line of the Delmarva Peninsula.