US 15 enters Prince Edward County as Farmville Road and crosses over Norfolk Southern Railway's Blue Ridge District west of the hamlet of Briery. The U.S. Highway passes through the hamlets of Redd Shop and Worsham before reaching Kingsville, where the highway intersects SR 133. SR 133 heads west to the community of Hampden Sydney and its namesake college. US 15 veers northeast and meets US 460 (Prince Edward Highway) at a diamond interchange. US 15 joins US 460 west on the four-lane freeway while US 15 Business heads toward the town of Farmville, home of Longwood University. US 15 and US 460 cross over Little Buffalo Creek, Buffalo Creek, and the High Bridge Trail, a rail trail on what was formerly a Norfolk Southern rail line. The U.S. Highways diverge at a trumpet interchange west of Farmville. US 15 exits onto Sheppards Road and has a brief concurrency with US 460 Business north to the northern end of US 15 Business (Third Street).