Coming off an impressive divisional road win over the Cardinals, the 49ers flew to Bank of America Stadium for a Week 13 intraconference game with the Carolina Panthers. In the first quarter, the Niners trailed early as Panthers kicker John Kasay nailing a 19-yard field goal for the only score of the period. In the second quarter, San Francisco continued to struggle as Carolina QB Vinny Testaverde completed a 5-yard to TE Dante Rosario, along with CB Richard Marshall returning an interception 67 yards for a touchdown.