James made her World Wrestling Entertainment (WWE) main roster debut in 2005 and was placed in a storyline with Trish Stratus, in which James' gimmick was that of Stratus' biggest fan turned obsessed stalker, an angle which ran over eight months. She received a push and she won her first WWE Women's Championship at WrestleMania 22, a title she has held a total of five times. James also won her first Divas Championship defeating Maryse Ouellet at Night of Champions in 2009, to become the second of five Divas to hold both the Women's and Divas titles. She was released from the company in April 2010, after which she returned to TNA, where she became a three-time TNA Knockouts Champion.