Following the 1998-99 season, Herrion left Drexel to take-over as head coach at East Carolina. Seymour was immediately tapped to succeed Herrion. He was fired by the university on March 7, 2001, following the completion of his second season as head coach. Under Seymour, Drexel compiled an overall record of 28-29, and never finished higher than third in the America East Conference. Reaction to Seymour's firing was generally negative in the Philadelphia area. He was succeeded as Drexel's head coach by Bruiser Flint, who had recently resigned as head coach at UMass. Seymour's termination coincided with Drexel's departure from the America East Conference, and joining of the Colonial Athletic Association.