Bush also served as a manager in professional baseball for the Washington Senators (1923), Indianapolis Indians (1924–1926, 1943–1944), Pittsburgh Pirates (1927–1929), Chicago White Sox (1930–1931), Cincinnati Reds (1933), Minneapolis Millers (1932, 1934–1938), and Louisville Colonels (1939). His 1927 Pittsburgh Pirates won the National League pennant and lost to the 1927 Yankees in the World Series. Bush was also a co-owner of the Louisville Colonels (1938–1940) and Indianapolis Indians (1941–1952), president of the Indians (1941–1952, 1956–1969), and a scout for the Boston Red Sox (1953–1955). He was given the title "King of Baseball" during Major League Baseball's 1963 winter meetings. He was known as "Mr. Baseball" in Indianapolis and was an inaugural inductee of the Indiana Baseball Hall of Fame.