Amy continued at the Welcome until she received a call to work among the mill girls of Manchester in 1889, from which she moved on to missionary work, although in many ways she seemed an unlikely candidate for missionary work, suffering as she did from neuralgia, a disease of the nerves that made her whole body weak and achy and often put her in bed for weeks on end. But at the Keswick Convention of 1887, she heard Hudson Taylor, founder of the China Inland Mission speak about missionary life; soon afterwards, she became convinced of her calling to missionary work. She applied to the China Inland Mission and lived in London at the training house for women, where she met author and missionary to China, Mary Geraldine Guinness, who encouraged her to pursue missionary work. She was ready to sail for Asia at one point, when it was determined that her health made her unfit for the work. She postponed her missionary career with the CIM and decided later to join the Church Missionary Society.