Edwards, like Winslow, had a successful rehabilitation that enabled him to be ready to play in the team's opening game in 2006. Edwards became the top receiver for the Browns after an injury to Joe Jurevicius that season. Edwards totaled 61 receptions for 884 yards and six touchdowns on the season. At the end of the season, Edwards announced he would give $500,000 to the University of Michigan for a scholarship endowment for football players. Edwards also had an altercation with Charlie Frye on the sidelines of a game in 2006. He said "and they're talking about video games." Edwards continued to make headlines that season when he called out Mike Minter, Chris Gamble, Ricky Manning and other defensive backs of the Carolina Panthers. Additionally, he attended the annual Michigan-Ohio State rivalry game after being advised not to go by several veteran captains. Edwards was late getting back from Columbus and was late to a team meeting.