From 12 May 2004 to 12 November 2004, "Crommelin" was deployed to the SOUTHPAC AOR with Coast Guard Law Enforcement Detachment (LEDET) 105 in support of the war on drugs, conducting counter-narcotics operations in the Pacific Ocean and Caribbean Sea. In that time, she became the most second most successful counter-narcotics ship with the seizure of of cocaine, including 26,369 pounds from the Belize-flagged vessel San Jose on 23 September 2004. She held that record until the bust of the Panamanian flagged motor vessel Gatun off the coast of Panama in March 2007, carrying approximately of cocaine. During this deployment, America's Battle Frigate also participated in exercises UNITAS-04 and PANAMAX-04, training the Navies and Coast Guards of various Central- and South-American countries in counter-narcotics and counter-terrorism tactics at sea.