In 2006, Sánchez added two stage wins in the Tour of the Basque Country and a second place on the steep finishing climb of the Belgian spring classic La Flèche Wallonne. He finished 4th overall in Paris–Nice, winning the points jersey in the process. In the Vuelta a España he won the 13th stage with a daring attack in a downhill section and finished 7th in the general classification. At the UCI Road World Championships in the Austrian city of Salzburg Sánchez played a major part by creating the decisive break in the final kilometre for his leader Alejandro Valverde. Sánchez himself finished 4th behind Paolo Bettini, Erik Zabel and Valverde. One week later he won Züri-Metzgete, his first classic. With to go he attacked to solo into Zürich with half a minute to spare over Stuart O'Grady and Davide Rebellin. Two weeks later he finished second in the Giro di Lombardia, and secured his second place in the final UCI ProTour classification.