In "Resident Evil 5", Chris is the protagonist of the game and is a founding member of the UN paramilitary group Bio-terrorism Security Assessment Alliance (BSAA). In the game, he investigates a terrorist threat in Kijuju, Africa while looking for Jill, who is missing and presumed dead. Accompanying him is his new partner Sheva Alomar. Eventually, they manage to find and free Jill, and ultimately defeat and destroy Wesker who was planning to release a new virus into the atmosphere, ensuring complete global saturation.