One of Fricker's first TV roles was staff nurse Maloney in "Coronation Street", debuting on 10 January 1977. Brenda's character attended on the birth of Tracy Barlow on 24 January 1977's episode. Fricker came to wider public attention in the United Kingdom in another nursing role, as Megan Roach in the BBC One television drama series "Casualty". Fricker bowed out as Megan in December 1990, after playing the character in 65 episodes, because she believed her character had "started off with a wonderful sense of humour, lost it all and all she ever seemed to do was push a trolley around and offer tea and sympathy". In February 1998 she appeared in two episodes, with Megan attending the wedding of her former colleagues Charlie Fairhead and Barbara 'Baz' Samuels. In 2007, she returned for a single episode for Red Nose Day. The episode was written by Richard Curtis. Fricker's final appearance as Megan was in August 2010, when the character took a lethal cocktail of drugs to end her life.