US 113 heads northeast from US 13 as a four-lane divided highway and intersects American Legion Drive (unsigned MD 359B), which leads to MD 359 (Bypass Road). The U.S. Highway crosses Town Branch, a tributary of the Pocomoke River, and leaves the Pocomoke City area after intersecting MD 756 (Old Snow Hill Road). US 113 parallels the left bank of the Pocomoke River and crosses many streams that drain into the river, including Pilchard Creek, Bachelors Branch, Mataponi Creek, Corkers Creek, and Hardship Branch. US 113 passes through Pocomoke State Forest, which preserves loblolly pine stands and bald cypress swamps along the Maryland Scenic River; by the Pocomoke River Wildlife Management Area, in which dove hunting regularly occurs; and by the Shad Landing unit of Pocomoke River State Park, which offers boating, fishing, and a nature center.