Pedro Santana was engaged to María del Carmen Ruiz, a local beauty, who was thrown from her horse, dying instantly, when her horse shied as she was returning to El Seybo from a pilgrimage to the sanctuary of Our Lady of Altagracia in Higüey. The death of his fiancée sent Santana into a deep depression. His twin brother Ramón, convinced Pedro to accompany him on a visit to his fiancée Froilana Febles, who lived in El Seybo. During his visits to his soon to-be sister-in-law, Pedro fell in love with his brother's future mother-in-law, the much older Micaela Antonia del Rivero, widow of the very wealthy Miguel Febles. This meant that Froilana Febles became Pedro Santana's sister-in-law and stepdaughter at the same time, while Micaela del Rivero became sister-in-law and mother-in-law of Ramón Santana. The Santana-del Rivero marriage was very unhappy, but it gave Pedro Santana influence and power in the Southeastern region.