Shortly after her return to South Africa in 1902, Maxeke began her involvement in anti-colonial politics. She, along with two other individuals from Transvaal, attended an early South African Native National Congress meeting, and was one of the few women present. Maxeke attended the formal launch of the South African Native National Congress in Bloemfontein in 1912. Maxeke also became active in movements against pass laws through her political activities. During the Bloemfontein anti-pass campaign, Maxeke served as an impetus towards eventual protest by organizing women against the pass laws.