Varney is the co-founder, creative director and producer of SF Sketchfest, the San Francisco Comedy Festival, and is also the co-founder of the San Francisco sketch group Totally False People. She is a core member of the Los Angeles based improv group "Theme Park Improv". She performed with the Los Angeles and San Francisco-based group Sequel 4000. In March 2012, she launched a podcast entitled "The JV Club", hosted on Nerdist.com from 2012 to 2018. In November 2018, it was announced that "The JV Club" would be moving to the Maximum Fun network.