To deliver nutrients aeroponic systems use hydro-atomized sprays that minimize water use, increase root oxygenation, and produce excellent plant growth. The nutrient solution throughput of aeroponic systems is higher than in other systems developed to operate in low gravity. Aeroponics’ elimination of substrates and the need for large nutrient stockpiles reduce the amount of waste material that needs to be processed by other life support systems. The removal of the need for a substrate also simplifies planting and harvesting (making automation easier), decreases the weight and volume of expendable materials, and eliminates a potential pathogen transmission pathway. These advantages demonstrate the potential of aeroponic production in microgravity and the efficient production of food in outer space.