Gamboa fought Gilberto Luque on 5 January 2008, at Bally's Hotel & Casino in Atlantic City, New Jersey. Gamboa sent his opponent to the canvas less than 30 seconds into first round with a left hand. After two more knockdowns, the referee stopped the fight. On 22 February 2008, in Fort Lauderdale, Florida, he made his American television debut against Johnnie Edwards. Gamboa knocked Edwards down in the first 30 seconds of the fight after connecting with a left hand to the head. Edwards got up, but was met with left-hand punches from Gamboa, ending with two consecutive right hands that knocked Edwards down for the second and final time as the referee moved in and halted the fight in round one. Gamoba won the vacant WBC-NABF super featherweight title.