Coming off a fierce divisional road win over the Rams, the 49ers flew to Heinz Field for an interconference duel with the Pittsburgh Steelers. In the first quarter, the Niners struck first with kicker Joe Nedney getting a 32-yard field goal. The Steelers immediately responded with CB–RS Allen Rossum returning a kickoff 98 yards for a touchdown. San Francisco wrapped up the period with Nedney kicking a 22-yard field goal. In the second quarter, Pittsburgh increased its lead with QB Ben Roethlisberger completing a 9-yard TD pass to TE Jerame Tuman for the only score of the period.