Despite being ranked 26 in the world, Müller's excellent form on grass in the last 12 months saw him earn a seeding of 16th at Wimbledon, where he made the quarterfinals after defeating world No. 2 Rafael Nadal in a five-set thriller, winning (6–3, 6–4, 3–6, 4–6, 15–13) in 4 hours and 48 minutes. The Luxembourger would subsequently have his run at The Championships ended by the eventual runner-up Marin Čilić, who beat him in another match that went five sets (6–3, 6–7, 5–7, 7–5, 1–6), after Müller experienced physical fatigue during the 5th set.