The Drake equation has been used by both optimists and pessimists, with wildly differing results. The first scientific meeting on the search for extraterrestrial intelligence (SETI), which had 10 attendees including Frank Drake and Carl Sagan, speculated that the number of civilizations was roughly between 1,000 and 100,000,000 civilizations in the Milky Way galaxy. Conversely, Frank Tipler and John D. Barrow used pessimistic numbers and speculated that the average number of civilizations in a galaxy is much less than one. Almost all arguments involving the Drake equation suffer from the overconfidence effect, a common error of probabilistic reasoning about low-probability events, by guessing specific numbers for likelihoods of events whose mechanism is not yet understood, such as the likelihood of abiogenesis on an Earth-like planet, with current likelihood estimates varying over many hundreds of orders of magnitude. An analysis that takes into account some of the uncertainty associated with this lack of understanding has been carried out by Anders Sandberg, Eric Drexler and Toby Ord, and suggests "a substantial "ex ante" probability of there being no other intelligent life in our observable universe".