Wine spent the next ten seasons, 1963 through 1972, in the major leagues. Wine was with the memorable 1964 Philadelphia team, which was in first place most of the year but collapsed in the last two weeks to let the St. Louis Cardinals take the pennant on the last day of the season. He played shortstop during the late innings of Jim Bunning's perfect game against the New York Mets on Father's Day of that year. His last season with the Phillies was 1968, when a back injury limited him to 27 games.