The street runs north east from Abbey Street and Bolton Street at Dominick Street junction, north of Parnell Square and Mountjoy Square, and leads into Drumcondra Road at Binn's Bridge on the Royal Canal. It makes up part of the most common route from Dublin Airport to the city centre, and the R132 regional road follows Dorset Street for part of its route. It meets the R135 route at the junctions with Blessington Street, location of the Blessington Street Basin, and St. Mary's Place; other major roads feeding onto this spine street include North Circular Road, Gardiner Street, Eccles Street, North Frederick Street, and Granby Row.