"All Over the Guy" is about Eli (Dan Bucatinsky) and Tom (Richard Ruccolo). The film is told mostly in flashback; with Eli recounting his side to Esther (Doris Roberts), an HIV clinic worker as he waits for test results and Tom telling his side to a man he meets at an Alcoholics Anonymous meeting. Tom is the son of emotionally distant alcoholic WASP parents who never quite accepted his sexual orientation and as a result is a heavy drinker himself and has a penchant for random hookups with different men. Eli's parents are both Jewish psychiatrists who raised him to be emotionally open but ended up making him neurotic.