Pigot entered the service of the East India Company in 1736, at the age of 17; after nineteen years he became governor and commander-in-chief of Madras in 1755. Having defended the city against the French in 1758-1759 and occupied Pondichéry on behalf of the company, he resigned his office in November 1763 and returned to the Kingdom of Great Britain, being made a baronet in 1764. After selling the family seat of Peplow Hall, Shropshire, he purchased Patshull Hall, Staffordshire, in 1765 for £100,000. That year he obtained the seat of Wallingford in the Parliament of Great Britain, which he retained until 1768. In 1766 he was created an Irish peer as Baron Pigot, of Patshull in the County of Dublin. From 1768 until his death he sat in the British House of Commons for Bridgnorth. Pigot was created an LL.D. of the University of Cambridge on 3 July 1769.