Architectural features in Prairie City include historic stone buildings and the former railway depot. The ground floor of the depot consists of a waiting room, railway station agent's office, baggage room, and freight office. The second floor, once the home of the station agent and his family, houses the Dewitt Museum, with pioneer artifacts, tools, furniture, and memorabilia, as well as rocks and minerals from the surrounding area. The depot was listed on the National Register of Historic Places in 1976.