Past this point, the route crosses the Tennessee River and the Lauderdale County line. The route passes through Florence on a freeway directly through town, junctioning with U.S. 72 and U.S. 43, also losing Alabama State Route 133 and gaining Alabama State Route 17 before and at this specific interchange respectively. On the north side of town, the route re-engages in a concurrency with S.R. 133 and now S.R. 17. After a short concurrency, the route drops S.R. 17 and continues west with S.R. 133. Eventually, it turns off of the concurrency and heads north, crossing the Tennessee state line directly beside the Natchez Trace Parkway. The route becomes Tennessee State Route 227, which loops around and acts as the northern terminus to Alabama State Route 101.