Weatherspoon is one of the original players of the WNBA in 1997 when she joined the New York Liberty in the WNBA's inaugural season. A talented ball-handler and charismatic leader, her energetic play quickly endeared her to the fans and media in New York. In 1997 she was the first winner of the league's Defensive player of the year award. She won the title again in 1998. During the 1999 WNBA Finals, Weatherspoon had one of the most memorable feats in WNBA history; in Game 2, the Liberty were down 67–65 against the Houston Comets with no timeouts left and 2.4 seconds left on the game clock after a shot made by Tina Thompson. After receiving the inbound pass, Weatherspoon dribbled the ball up to half court and made a game-winning shot 50 feet away from the basket to force a Game 3. That moment would later be referred to as "The Shot". Up until the 2003 season, she held the distinction of being the only WNBA player to start every one of her games. After the 2003 season, she was not re-signed by the Liberty and signed with the Los Angeles Sparks. After her 2004 season with the Sparks, Weatherspoon retired.