In 1832, General Francis Preston built the brick residence for his family at a cost of $15,000. The mansion remained in the Preston family possession until 1858, when it was sold at the cost of $21,000 to the founders of Martha Washington College. The college devoted entirely to women operated for seventy years until finally succumbing to the Great Depression. At the time of the Civil War, the college served as the training ground for the Confederate unit, the Washington Mounted Rifles. After various skirmishes between United States and Confederate forces, wounded were brought to the school for treatment. It was also during this time period that the building attained the nickname, "The Martha." Among its post-war alumnae was the valedictorian of the Class of 1880, Nellie Nugent Somerville, who would go on to become the first woman elected to the Mississippi Legislature.