James and Stratus teamed together at the March 18, 2006 "Saturday Night's Main Event XXXII" to defeat Candice Michelle and Victoria. After the match, James agreed to honor Stratus' wishes and attempted to kiss her. After Stratus pushed her away, James attacked Stratus and vowed to destroy her, turned heel in the process for the first time in her WWE career. The feud between James and Stratus culminated in a Women's Championship match at WrestleMania 22, which James won, to earn her first Women's Championship in what was looked at as one of the best female matches ever produced at WrestleMania. Her angle with Stratus continued into Backlash during a rematch, after Stratus legitimately dislocated her shoulder when James threw her out of the ring. The feud would come to an end on the June 26 episode of "Raw", when Mickie defeated Stratus in a Women's Championship match.