From 1916 to 1927, the route was a part of pre-1927 Route 5, which ran from Delaware in Warren County east to Newark. In 1927, the portion of pre-1927 Route 5 that is today Route 53 was not made a part of a different route and became Route 5N to distinguish it from a newly created Route 5. In 1953, the route became Route 53. A freeway was planned for the route in 1966, running from a planned Route 24 freeway in Morris Plains north to a planned Route 208 freeway in Greenwood Lake in Passaic County. This planned freeway was scaled back in 1967 to end at Interstate 80. It was later designated Route 178 before being canceled in 1975.