Manthatisi, the daughter of Chief Mothaba of the Basia people who were a sibling nation of Batlokwa, in what later became the Harrismith district of the Free State province of South Africa, was reportedly a tall, attractive woman. She married Mokotjo, the chief of the neighboring Batlôkwa, in a typical dynastic alliance, and is said to have borne him four sons. Mokotjo died while the heir, Sekonyela, was still too young to assume the chieftaincy, so Manthatisi acted as regent for Sekonyela.