After US 20, NY 249 continues eastward on Brant–Farnham Road, crossing under the lanes of the New York State Thruway (I-90), however no interchange is present. After the Thruway, the route crosses south of Brant Town Park as it heads east as a two-lane residential roadway. Approaching the hamlet of Brant, NY 249 intersects with the southern terminus of CR 492 (Hardpan Road). In Brant, NY 249 becomes a two-lane commercial street through the center of town, intersecting with CR 9 (Angola Brant Road). This intersection served as the southern terminus of NY 323 until August 14, 1980. After CR 9, NY 249 continues eastward, changing names to Brant–North Collins Road.and soon winding its way through the rural sections of Erie County.