Cuypers was born in Roermond, the son of a church painter, and grew up in surroundings in which interest for art was encouraged. After he studied at the urban college in Roermond, he moved to Antwerp in 1844 to study architecture at the Royal art academy. He was taught by Frans Andries Durlet, Frans Stoop and Ferdinand Berckmans, all pioneers of the neo-Gothic architecture in Belgium. Cuypers was a good student; in 1849, he gained the "Prix d'Excellence" of the academy.