Printezis was selected by the San Antonio Spurs in the second round, with the 58th selection overall of the 2007 NBA draft. The draft rights to Printezis were then acquired by the Toronto Raptors, in exchange for their second round draft pick in the 2008 NBA draft (Spurs used that pick to draft Goran Dragić, and immediately traded Dragić to the Phoenix Suns to acquire the draft pick they used in 2009 to draft future NBA All-Rookie Second Team member DeJuan Blair). On January 20, 2011, the Toronto Raptors traded his draft rights to the Dallas Mavericks for Alexis Ajinça, a conditional second 2013 second round draft pick, and cash.