In the United States, more than 12 million people use opioid drugs recreationally. Opioids were responsible for 49,000 of the 72,000 drug overdose deaths in the U.S. in 2017. In September 2013, the FDA released new labeling guidelines for long acting and extended release opioids requiring manufacturers to remove moderate pain as indication for use, instead stating the drug is for "pain severe enough to require daily, around-the-clock, long term opioid treatment." The updated labeling will not restrict physicians from prescribing opioids for moderate, as needed use.