MD 190 crosses Cabin John Creek and expands to a four-lane divided highway just west of Seven Locks Road. The state highway has a partial cloverleaf interchange with I-495 (Capital Beltway) that includes access to Cabin John Parkway. East of the Capital Beltway, the route becomes a partially controlled access highway, with adjacent properties accessed by service roads or intersecting streets. MD 190 passes to the south of the Burning Tree Club and the Holton-Arms School before crossing Booze Creek. The highway continues through the southern part of Bethesda, where the road intersects MD 188 (Wilson Lane) and MD 614 (Goldsboro Road); between the two highways, the highway passes Walt Whitman High School. MD 190 loses access of control and becomes an undivided road with a center left-turn lane west of its underpass of the Capital Crescent Trail. The highway becomes an undivided four-lane road between its intersection with Little Falls Parkway and its crossing of Little Falls Branch. MD 190 reaches its eastern terminus at Western Avenue at the District of Columbia boundary. River Road continues into Washington as a two-lane unnumbered street that ends at Wisconsin Avenue in Tenleytown.