Alongside "The Simpsons", Smith appeared in the sitcom "Herman's Head" as Louise, and had recurring appearances as Marlene on "Dharma & Greg" and as Penny in two episodes of "Dead Like Me". She has appeared in several films, including "City Slickers", "Just Write", "Toys" and "As Good as It Gets". In 2004, Smith performed an off-Broadway one-woman show entitled "More" at the Union Square Theatre in New York City. Aside from "The Simpsons", Smith has recorded few voice-over parts, only commercials and the film "We're Back! A Dinosaur's Story". Smith starred in and served as executive producer for the independent romantic comedy "Waiting For Ophelia", which had its world premiere at the Phoenix Film Festival in April 2009.