In April 2006, Shimabukuro came to national and international attention when, unbeknownst to him, someone posted a virtuosic video of him playing George Harrison's "While My Guitar Gently Weeps" on YouTube. The video, which had originally been filmed for a New York television show called "Midnight Ukulele Disco", quickly went viral, and has received over 15 million views. The video performance resulted in a huge increase in concert engagements, and Shimabukuro received collaboration requests from notable musicians including Jimmy Buffett, Béla Fleck, Ziggy Marley, Cyndi Lauper, Keali'i Reichel, and Yo-Yo Ma. He toured with Buffett in 2005, 2006 and 2007, and is featured on several of Buffett's albums and videos, including his 2007 CD/DVD release "Live in Anguilla". Shimabukuro also began receiving many invitations to perform on major U.S. talk shows and other well-known media ventures, and began touring worldwide eight or nine months a year.