In April 2019, Molinari was the 54-hole leader at the Masters at 13 under, two strokes clear of Tony Finau and Tiger Woods, after a six-under-par 66 third round. Molinari held the lead for two thirds of the final round, until he reached the par-3 12th, where his tee shot found the water, resulting in a double bogey. He found the water again on the 15th, which led to another double bogey to fall out of contention. He finished with a round of 74 and T5 finish, still his best performance at the Masters to date.