Gibson made the All-Star team again in the 1965 season, and when the Cardinals were well out of the pennant race by August, attention turned on Gibson to see if he could win 20 games for the first time. Gibson was still looking for win number 20 on the last day of the season, a game where new Cardinals manager Red Schoendienst rested many of the regular players. Gibson still prevailed against the Houston Astros by a score of 5–2. The 1966 season marked the opening of Busch Memorial Stadium for the Cardinals, and Gibson was selected to play in the All-Star Game in front of the hometown crowd that year as well.