Born John Richard Chambers in London, Ontario, Chambers signed his name as John until 1970 and thereafter was known as Jack professionally and posthumously. Chambers spent eight years (1953–1961) studying and working in Europe after studying at H.B. Beal Secondary School and the University of Western Ontario. While in Europe he met Pablo Picasso, who suggested he continue his studies in Barcelona. He called his own work "perceptual realism," a kind of surrealism based on his own dreams and memories and the existentialist philosophy of Maurice Merleau-Ponty. When he returned to London, Chambers worked with fellow London native Greg Curnoe. In 1969 he was diagnosed with leukemia. For the rest of his life he painted more realistically, often depicting sites in London and the surrounding area. An example of this is "401 Towards London No. 1" (1968–1969), a view of Highway 401 heading westward towards London.