Upon the entry of the United States into World War II, "Charleston" intensified the schedule of patrol and convoy escort duties necessary to protect this far-northern region, and except for four voyages to west coast ports for maintenance, she operated from Dutch Harbor or Kodiak, Alaska throughout the war. Along with her escort and patrol duties, she carried out such missions as landing reconnaissance parties, aiding stricken ships, and taking part in the operations at Attu Island, which was assaulted on 11 May 1943. Two days later, "Charleston" arrived to bring her firepower to support Army troops ashore, bombarding Chichagof Harbor, Alaska, and screening the transports lying off the island. During the attack of Japanese bombers on 22 May, she evaded aerial torpedoes by radical maneuvering, while splashing one enemy plane and helping to drive off the others. She provided call fire until the island was secured, and supported its occupation through convoy escort runs between Attu and Adak Islands.