On June 17, 2019, it was announced that several of Megadeth's shows of that year (with the exception of MegaCruise) would be cancelled due to Mustaine being diagnosed with throat cancer; of all the cancelled dates, the band was supposed to support Ozzy Osbourne on the North American leg of the latter's No More Tours II, which had been postponed from the summer of 2019 to the next year, and Megadeth was replaced by Marilyn Manson. Despite Mustaine's illness, the band vowed to continue working on their new album. Megadeth re-entered the studio in Nashville in mid-2020 to resume recording their new album, which is tentatively planned for release in 2021.