Freleng and McKimson soon set Sylvester up as Speedy's regular nemesis in a series of cartoons, much in the same way Chuck Jones had paired Wile E. Coyote and the Road Runner in his Road Runner cartoons. Sylvester (often called ""El Gringo Pussygato"" by Speedy) is constantly outsmarted and outrun by the Mouse, causing the cat to suffer all manner of pain and humiliation from mousetraps to accidentally consuming large amounts of Tabasco hot sauce. Other cartoons pair the mouse with his cousin, Slowpoke Rodriguez, the "slowest Mouse in all Mexico." Slowpoke regularly gets into all sorts of trouble that often require Speedy to save him—but one cat in "Mexicali Shmoes" says that as if to compensate for his slowness, "he pack a gun!" In the mid 1960s, Speedy's main rival and second nemesis became Daffy Duck, whom Speedy usually referred to as "the duck."