In order to make hydroponic and aeroponic systems inherently more resilient to plant disease and less reliant upon chemical supplementation, NASA investigates environmental biocontrols integrated into the system’s design. For example, NASA’s Advanced Plant Habitat (APA) has been in operation on the ISS since 2018. The APA is equipped with more than 180 sensors which allows for the optimization of plant growth, health, and monitoring in space, while decreasing reliance upon chemical additive biocontrols. These environmental controls and sensors include lighting (intensity, spectrum, and photoperiod), temperature, CO2, relative humidity, irrigation, as well as plant-derived ethylene and volatile organic compound (VOC) scrubbing. Additionally, APA is equipped with leaf temperature sensors, root zone temperature, root zone moisture sensors, as well as oxygen concentration meters.