For a number of reasons, in particular the civil war that raged during the reign of John II and the subsequent conflicts involving the peasant farmers, the official "Estudi General" of Barcelona did not begin to develop until the reign of Fernando the Catholic; but it was under Charles I, in 1536, that the foundation stone was laid for the new university building at the top end of La Rambla. From that moment on the university began to carry out its work as normal despite financial difficulties and in-fighting between university teachers, though this was not to stop some illustrious professors from making their mark in their respective fields and creating their own schools of academic followers.