After leaving Middletown Center, PA 858 continues northward and sometimes northeastward. After Middletown Center, PA 858 is surrounded by nothing but trees. There is a break in the trees when PA 858 intersects with an unnamed road, which serves as a connector to Township Road 768 (TR 768). The state traffic route continues to the northwest, intersecting with TR 687. As PA 858 continues, it enters Apolacon Township, where the dense forestry begins to break, and homes begin to show the way. After a short pond is passed, the highway enters the borough of Little Meadows. At Maple Avenue, PA 858 runs on its final stretch, passing homes all the way to the New York state line. There, PA 858 ends and becomes CR 41 upon entering Tioga County, New York.