Abby's ex-boyfriend Brandon is found dead and Anthony frames Abby. Lisa befriends Kristina and gives her hydrocodone masked as herbal supplements, then sneaks around Robin and Patrick's house while Kristina is passed out babysitting. Lisa attempts to trap Robin in the basement and frame Patrick for her death. Robin and Patrick catch her in the act and Lisa is arrested. Lisa breaks out of prison and goes to Johnny for help. Eventually, Anthony helps her. Meanwhile, Lulu buys The Haunted Star, hoping to entice Luke back. Lucky finds Luke in the bordello he grew up in. Luke tells Lucky that Jake's death liberated him. Lucky returns to Port Charles, and torches the old Spencer house, accidentally injuring Siobhan. Meanwhile, Lisa enters the hospital and they go into lockdown. Liz is trapped in Siobhan's operating room, and accidentally gives Siobhan the wrong medication. Lisa takes Maxie, Steve, Robin, and Patrick hostage and performs a mock trial. Spinelli comes through the air vent and takes a bullet for Maxie. Jason and Dante lift the lockdown, and Dante knocks Lisa out. While everyone is distracted saving Spinelli, Lisa regains consciousness and holds a syringe filled with drain cleaner to Robin's neck. Patrick tackles her, and Lisa lets him stab her with the syringe. Spinelli wakes up, but is acting like the 'Jackal P.I.' character from his book.