In "Afterlife with Archie", Reggie Mantle caused the zombie apocalypse. Midge asks him for money so she can pay for an abortion. This frustrates and angers him to the point that when he sees Hot Dog on the side of the road he swerves to hit him. He immediately regrets his actions and tries to carry Hot Dog to a vet, failing that, he takes him to Jughead's lawn so that he can die at home. Hot Dog's subsequent reanimation results in him infecting Jughead and starting the zombie apocalypse.