In 2010, Keselowski replaced David Stremme in the No. 12 Dodge Charger in the Cup Series and ran the full Nationwide Series schedule as well in the No. 22 Discount Tire. In Atlanta, on lap 41, Keselowski unintentionally tapped Carl Edwards on a restart and Edwards went up to the wall to collect Joey Logano. Later, Keselowski appeared to be headed toward a top-5 finish at Atlanta with three laps to go when Edwards, apparently in retaliation for this accident, intentionally spun Keselowski. Keselowski's car caught air and despite the roof flaps working his car overturned, hitting the front-stretch wall roof-first in an accident that resembled the Talladega finish of the previous year. His new teammate Kurt Busch ended up winning the race. Edwards was parked by NASCAR and Keselowski was physically okay, but shaken up from the heavy impact.