Darkdevil has fought alongside Spider-Girl several times, as well as the semi-retired Spider-Man. Neither Spider-Man nor Spider-Girl are aware of his genetic relation to them, but Darkdevil has hinted that he owes his existence to the original Daredevil, Spider-Man, and Kaine. Mary Jane noticed Reilly at Normie Osborn and Brenda Drago's wedding party and attempted to point out to her husband the boy that resembled him. Peter Parker cluelessly mentions that Reilly resembles Tobey Maguire, a sly nod by writers to the fact that Maguire played Spider-Man in three films.