State Route 22 (SR 22) is a long state highway spanning Yakima and Benton counties in the US state of Washington. Existing since at least 1937, the highway serves to connect several small communities that have been bypassed by Interstate 82 (I-82) / U.S. Route 12 (US 12). Except for the section through Toppenish and the southeastern bypass of Prosser, the highway is lightly traveled passing mainly through rural farmland. The highway parallels a BNSF Railway line for a majority of its route, with the rail line predating the highway by at least 27 years.