Suggs made his debut with the Cardinals in Week 1 against the Detroit Lions. In the game, Suggs sacked Matthew Stafford twice in the 27–27 tie. Week 2 of the 2019 season saw Suggs go to Baltimore for the first time in an opposing team's jersey. As Suggs ran onto the field he received a standing ovation from Ravens fans. He had one solo tackle during the Cardinals' 23–17 loss. The Ravens eventually went 14-2, but lost in the Divisional Round against the Tennessee Titans. The Cardinals finished the season 5-10-1, and Suggs went to the Chiefs.