As well as the work on reactor development, the Metallurgical Laboratory studied the chemistry and metallurgy of plutonium, and worked with DuPont to develop the bismuth phosphate process used to separate plutonium from uranium. When it became certain that nuclear reactors would involve radioactive materials on a gigantic scale, there was considerable concern about the health and safety aspects, and the study of the biological effects of radiation assumed greater importance. It was discovered that plutonium, like radium, was a bone seeker, making it especially hazardous. The Metallurgical Laboratory became the first of the national laboratories, the Argonne National Laboratory, on 1 July 1946. The work of the Met Lab also led to the creation of the Enrico Fermi Institute and the James Franck Institute at the university.