Nick, who survived Lucifer's death and suffers psychological damage from so many years of being Lucifer's vessel, sets about getting justice for the deaths of his family. His killing spree leads him to the prophet Donatello Redfield, and Nick communicates with the recently awakened Lucifer in the Empty. Nick tricks Jack into giving him Jack's blood, and tries to resurrect Lucifer to be his vessel again. Jack confronts, and then kills Nick in front of Mary. After Mary berates Jack for viciously murdering Nick, the now soulless Jack kills Mary by accident, leaving the boys without their mother for a second time. Castiel prays for God to return and fix Jack, but the angels manipulate Jack into solidifying their power. Out of options, Sam and Dean imprison Jack in the Mal’ak Box, but Jack escapes. God returns and tells the boys that they must use a gun that he built to kill Jack, but Sam and Dean, frustrated with God's disappearances and inaction, refuse him.