On July 1, 2007, Thames hit a solo home run in the bottom of the eighth inning to score the only run in the game in a victory over the Minnesota Twins. On July 6, he hit the third grand slam of his career at Comerica Park against the Boston Red Sox. On July 8, Thames hit one of the longest home runs in the history of Comerica Park. Batting against pitcher Daisuke Matsuzaka of the Red Sox, Thames hit a home run to deep center field that bounced off the camera area. The last Tiger to hit a home run to that area was Eric Munson in 2004.