By 1649 the Kiskiack had settled along the Piankatank River, where the English granted their "weroance" "Ossakican" (or Wassatickon) a reservation of . In 1651, the Kiskiack exchanged this land for another tract farther upriver. Soon the English began to encroach on that reservation in Gloucester County as well. In 1669 the Kiskiack were recorded as having only 15 bowmen. They last appeared in historical records as participants in the 1676 Bacon's Rebellion. The remaining Kiskiack appear to have merged and intermarried with other groups, probably the Pamunkey, Chickahominy, or Rappahannock.