New York State Route 291 (NY 291) is a state highway in Oneida County, New York, in the United States. The route extends from an intersection with NY 69 in the town of Whitestown to a junction with NY 365 in the extreme northern tip of the town of Marcy, near the hamlet of Stittville. It is a two-lane highway its entire length. NY 291 meets NY 49, the Utica–Rome Expressway, at an interchange roughly northeast of NY 69. NY 291 provides access to the Marcy Correctional Facility and Mid-State Correctional Facility, both in Marcy.