Dressed up in their throwback uniforms, the 49ers began their 2007 campaign against their NFC West rival, the Arizona Cardinals in the second game of the Monday Night Football doubleheader. In the first quarter, the Niners drew first blood as RB Frank Gore got a 6-yard TD run for the score of the period. However, in the second quarter, the Cardinals took the lead with kicker with Neil Rackers getting a 35-yard field goal and RB Edgerrin James getting a 7-yard TD run. San Francisco ended the half with kicker Joe Nedney getting a 33-yard field goal.