The Wayne Valley High School Indians compete in the Big North Conference, which is comprised of public and private high schools in Bergen and Passaic counties, which was created following a reorganization of sports leagues in Northern New Jersey by the New Jersey State Interscholastic Athletic Association. In the 2009-10 school year, the school competed in the North Jersey Tri-County Conference, which was established on an interim basis to facilitate the realignment. Prior to the realignment, the school had participated in the Northern Hills Conference's Skyline Division. With 994 students in grades 10-12, the school was classified by the NJSIAA for the 2019–20 school year as Group III for most athletic competition purposes, which included schools with an enrollment of 761 to 1,058 students in that grade range. The school was classified by the NJSIAA as Group IV North for football for 2018–2020.