"Resident Evil 6" sees Chris return as one of the three protagonists alongside Leon S. Kennedy, and Jake Muller, the son of Albert Wesker. In the game, Chris leads a squad of BSAA soldiers to investigate a bio-terror attack in Europe. Ambushed by Carla Radames, posing as Ada Wong, they suffer severe casualties. Only Chris and Piers Nivans survive the assault, with the rest of his team being turned into monsters by Carla. Chris is overwhelmed with guilt and resigns from the BSAA. Piers convinces Chris to rejoin the BSAA to avenge their fallen comrades. They travel to China to investigate bio-terror activity and find themselves in another C-virus outbreak. While attempting to rescue Jake Muller, who possesses the anti-bodies needed to stop the outbreak, Chris and Piers encounter HAOS, a powerful BOW. Piers is grievously injured during the battle and injects himself with the C-virus to gain super-human powers. He saves Chris, but sacrifices himself to ensure HAOS is destroyed. Chris continues to serve the BSAA in Piers' memory.