In 1790 the Rev. Enoch George was admitted on trial by the Virginia Annual Conference of the M.E. Church. He was ordained, both "Deacon" and "Elder," by Bishop Asbury. Rev. George served for two years as the Junior Preacher on the Caswell Circuit. He then went to South Carolina, where in 1796 he was appointed Presiding Elder of the Charleston District. In 1798, because of impaired health, he temporarily retired from the active work of ministry and traveled to the North. But in 1800 he resumed his labors, and was appointed Presiding Elder of the Potomac District in the Baltimore Annual Conference.