The occurrence of intense religious feelings in persons with epilepsy in general is considered rare, with an incident rate of about 2–3%. Sudden religious conversion, together with visions, has been documented in only a small number of individuals with temporal lobe epilepsy. The occurrence of religious experiences in TLE-patients may as well be explained by religious attribution, due to the background of these patients. Nevertheless, the neurological research of mystical experiences is a growing field of research, searching for specific neurological explanations of mystical experiences. Study of ecstatic seizures may provide clues for the neurological mechanisms giving rise to mystical experiences, such as the anterior insular cortex, which is involved in self-awareness and subjective certainty.