While some very venomous spiders do not always inject venom when they bite, these spiders most often do. The volume of venom delivered to large animals is often small, possibly due to the angle of the fangs, which are not horizontally opposed, and because contact is often brief before the spider is brushed off. About 10 to 25% of bites are claimed to produce significant toxicity, but the likelihood cannot be predicted and all bites should be treated as potentially life-threatening.