East Greenbush, at the time part of the Town of Greenbush, was part of the Manor of Rensselaerswyck, and then of Albany County, prior to the creation of Rensselaer County in 1791. The town of Clinton was established on February 23, 1855 from the town of Greenbush at the same time as the town of North Greenbush. Three years later, on April 14, 1858, the town name was changed to East Greenbush by New York State Laws of 1858, Chapter 194.