He is also known for his roles in Kevin Smith films such as "Mallrats", "Chasing Amy", "Dogma", "Jay and Silent Bob Strike Back", "Jersey Girl", "Clerks II", & "Cop Out". Lee won the Independent Spirit Award for Best Supporting Male for his performance in "Chasing Amy". He also portrayed David Seville in the live-action/CGI "Alvin and the Chipmunks" film series. His other notable film roles include starring in "Enemy of the State", "Vanilla Sky", "Big Trouble", "Stealing Harvard", "A Guy Thing" and "The Ballad of Jack and Rose". His voice acting credits include Syndrome in "The Incredibles", Bones in "Monster House" and the title character in "Underdog".