US 113 enters Sussex County to the east of the Great Cypress Swamp in the town of Selbyville, which was a center of strawberry production from the 19th century to the 1930s. The highway crosses Sandy Branch and intersects DE 54 (Cemetery Road/Cypress Road), which heads east to Fenwick Island. The U.S. Highway heads north parallel to the Maryland and Delaware Railroad to the town of Frankford, which was founded around a country store and the site of the Gothic Revival home of Captain Ebe Chandler. The highway crosses Vines Creek, the southernmost of several Indian River tributaries the route crosses, and passes along the western edge of the town. US 113 continues northwest parallel to the rail line, which north of Frankford is operated by the Delmarva Central Railroad as the Indian River Subdivision line.