In 2016, Birkin appeared in an ongoing campaign for Yves Saint Laurent shot by Hedi Slimane, which featured various female musicians, including Marianne Faithfull, Courtney Love, and Joni Mitchell. The same year, she had the lead role in "La femme et le TGV", a short film directed by Swiss filmmaker Timo von Gunten. The film was nominated for an Academy Award for Best Live Action Short Film. In a 2017 interview, Birkin stated that "La femme et le TGV" would be her final acting performance, and that she had no plans to return to acting.