Frank W. Gunsaulus attended public schools in Chesterville and was admitted to Ohio Wesleyan University, Delaware, Ohio at the age of 16. He was known by his classmates and professors to have a ravenous appetite for reading "the classics" coupled with a prodigious memory and a keen intellect. Always a popular student on campus, his classmates and professors were amazed by his public speaking skills and frequently made a point to attend his regular oratories at the school, where many claimed they were spellbound by his charm, wit, passion, and intelligence. He graduated from Wesleyan in 1875 at the age of 19 and was married that year to Georgeanna (Anna), daughter of George Long of Parsons, West Virginia and 1875 graduate of Ohio Wesleyan Female College.