Mukerji, Roshan, and Kareena Kapoor were cast as the leads; it marked the latter two's third collaboration, after "Yaadein" (2001) and "Kabhi Khushi Kabhie Gham..." (2001). Mukerji (as Pooja Sahani) said that she "loved every moment of working" on "Mujhse Dosti Karoge!", and described the film as a "privilege" for her. Roshan portrays Raj Khanna, a part that he compared with his role in "Kaho Naa... Pyaar Hai" (2000). He spoke of his rapport with Mukerji, claiming that it "was a pleasure working with her. She is very professional, very friendly and easygoing. She leaves all negativity behind when she comes on the sets." Interviewed by Rediff.com, he said that "Mujhse Dosti Karoge!" was "a very, very intense film", adding, "The second half is propelled forward by the intensity of my character Raj." He further stated that the film "more [...] about three friends than a love triangle".