At the 2011 World Championships in Khanty-Mansiysk, Neuner won three gold and two silver medals. She claimed silver, alongside Andrea Henkel, Arnd Peiffer and Michael Greis, in the opening mixed relay. On 5 March 2011, Neuner won the sprint race courtesy of a clean shooting performance. She finished second in the pursuit and fifth in the individual subsequently. On 12 March 2011, Neuner won her second title in the mass start despite of four shooing errors. The following day she also claimed gold in the women's relay, together with Andrea Henkel, Miriam Gössner and Tina Bachmann. Running the last leg for Germany, Neuner started in fourth, 67.5 seconds off the lead, but she pulled back the entire time and moved in front on the last lap. Her five medals made her the most successful female athlete in the history of Biathlon World Championships.