Homebush Railway Station is significant for its rare collection of railway structures dating from 1891 that form a unique and cohesive group. Designed under the direction of Commissioner Edward Eddy, the platform buildings demonstrate the first use of island platforms in NSW and are one of only four extant examples of 1891 "Standard Eddy" platform buildings. The 1891 overhead booking office is also a rare structure being one of only three similar structures representing the earliest use of above-platform buildings. The station buildings including the signal box, brick store rooms and footbridge collectively demonstrate a former era of travel, communication and trade. The group remains highly intact.