Acremonium strictum is an environmentally widespread saprotroph species found in soil, plant debris, and rotting mushrooms. Isolates have been collected in North and Central America, Asia, Europe and Egypt. "A. strictum" is an agent of hyalohyphomycosis and has been identified as an increasingly frequent human pathogen in immunosuppressed individuals, causing localized, disseminated and invasive infections. Although extremely rare, "A. strictum" can infect immunocompetent individuals, as well as neonates. Due to the growing number of infections caused by "A. strictum" in the past few years, the need for new medical techniques in the identification of the fungus as well as for the treatment of human infections has risen considerably.