Though known by his friends to have been a vocal supporter of the Convention People's Party (CPP) while a student in the University of Ghana, he switched sides to the rival UP tradition following the overthrow of President Nkrumah in 1966 after which his father, Edward Akufo-Addo became ceremonial president of Ghana in 1969. Akufo-Addo's participation in politics formally began in the late 1970s when he joined the People's Movement for Freedom and Justice (PMFJ), an organisation formed to oppose the General Acheampong-led Supreme Military Council's Union Government proposals. In May 1995, he was among a broad group of elites who formed Alliance for Change, an alliance that organised demonstrations against neo-liberal policies such as the introduction of Value Added Tax and human rights violations of the Rawlings presidency. The forefront of this demonstration were himself, Abdul Malik Kwaku Baako and Saifullah Senior minister Victor Newman, Kwasi Pratt Jnr, Dr. Charles Wreko Brobbey among others. They were joined by about 100,000 other people. The protest was named "Kumepreko". The broad-based opposition alliance later collapsed as the elite leaders jostled for leadership positions. In the 1990s, he formed a civil rights organisation called Ghana's Committee on Human and People's Rights.