When the Bajoran wormhole is discovered, Quark helps broker deals between several Gamma Quadrant races and the Ferengi. The Alpha Quadrant's first knowledge of the Dominion comes through his business dealings in the Gamma Quadrant with the Karemma of the Dominion. Quark becomes Grand Nagus for a brief period when it appears that Zek had died; however, Zek's death turns out to be a ruse and Quark is promptly deposed. Along with Commander Sisko, Quark is also among the first to encounter the genetically engineered soldiers of the Dominion, the Jem'Hadar.