The destroyer made still another cruise to the Far East 1959-60, sailing on 30 October. She operated with the 7th Fleet's hunter-killer force off Okinawa during November and December, arriving Formosa on 4 January 1960 for patrol duty. She returned to San Diego on 12 March 1960. In June, "John A. Bole" served as an air-sea rescue station ship for President Dwight D. Eisenhower's flight across the Pacific, and during the summer she embarked NROTC Midshipmen for training. In October she was assigned to a hunter-killer group built around , and after training, departed on 4 March 1961 for the Far East. The ships carried out further training, this time with Canadian ships out of Pearl Harbor, but with a worsening of the Laos situation, steamed to Subic Bay to bolster Navy strength and deter more serious trouble. Hunter-killer operations continued until September, and "John A. Bole" returned to California via the northern great-circle route to help gather hydrographic data, arriving her home port on 18 September.