NY 68 begins at an intersection with NY 37 (the Seaway Trail) in Ogdensburg. The route heads to the northeast, along the outskirts of downtown Ogdensburg. Along the way, it passes residential homes and several commercial businesses, parallelling the MacDonald-Cartier Freeway (Highway 401) to the north in Ontario and NY 37 to the south. NY 68 crosses a branch of the St. Lawrence River in downtown Ogdensburg, passing Crescent Park soon after. NY 68 heads to the south, intersecting with NY 37 once again along with NY 812 near the Seaway Shopping Center.