Morley started her career in Cincinnati in 1930, but is best remembered for her years in San Francisco and her second career in India. She formed some passionate friendships with women during this time. From 1946 to 1949, Morley worked for UNESCO in Germany as a consultant with French, American, and British authorities. She helped with theft and the return of multiple artworks. In 1949, she returned to San Francisco as a popular art star. Due to her fame and travels to Brazil, Chile, and Greece, the San Francisco Museum of Art became very well known across the world. However, in 1958, she decided to leave San Francisco along with her ties to the museum due to disagreements with the board of directors. "After being forced to leave S.F. in 1958, she cut off ties with most of her friends and colleagues in the Bay Area, which is one reason her memory has been somewhat buried," Morley scholar Kristy Phillips wrote in a 2006 e-mail on ArtsJournal.com. "She felt betrayed here by the museum and its trustees and at one point declared that she wanted to forget S.F. completely." In 1959, she served as the assistant director of the Guggenheim Museum before she decided to move to India in 1960.