The Royal Berkshire Hospital was opened in 1839 on the London Road on land donated by Henry Addington, 1st Viscount Sidmouth, a local resident and former Prime Minister. The hospital was built by local architect and builder Henry Briant, who won the design competition. King William IV took a keen interest in the hospital before it was built and as a consequence, his arms appear on the central pediment, although he died before the hospital opened. The first patron of the hospital was William's niece and successor, Queen Victoria.