After completing Economics and Commerce studies at Harvard University, Landesberg returned to Israel and opened a factory in Bat Yam. At the time, Sano had only four employees, one machine and three products. In 1963, Sano began selling 3M Scotch-Brite, a move that was profitable. In 1969, the company began producing mosquito repellant, cockroach control, and an air freshener named 'Sano Fresh'. In 1972, the company moved the factory to Hod Hasharon where it has since expanded and operates its main distribution center and factories.