In 1986, President Reagan promoted Weld to head of the Criminal Division of the Justice Department in Washington, where Weld oversaw 700 employees. Weld was responsible for supervising all federal prosecutions, including those investigated by the FBI and the Drug Enforcement Administration, as well as the work of the 93 U.S. Attorneys (who by then included Rudy Giuliani in Manhattan). During this time, Weld worked on some of the Reagan administration's most significant prosecutions and investigations, including the capture of Panama's Manuel Noriega on drug trafficking charges.