In 2006, Tropical Smoothie Cafe opened their 200th store in Virginia Beach, Virginia, and in 2011 they opened their 300th store in Fort Myers, Florida. They opened their 400th location in Toledo, Ohio, 500th location in Westland, Michigan, and in 2017 their 600th location in Joplin, Missouri. They opened their 800th location in Arlington Heights, IL in 2019. Tropical Smoothie Cafe is now opening a new store at a pace of every 3–4 days, an improvement from their pace of every 6–7 days in 2007, their 10th anniversary year.