Heavy guns based on the Maxim such as the Vickers machine gun were joined by many other machine weapons, which mostly had their start in the early 20th century such as the Hotchkiss machine gun. Submachine guns (e.g., the German MP 18) as well as lighter machine guns (the first light machine gun deployed in any significant number being the Madsen machine gun, with the Chauchat and Lewis gun soon following) saw their first major use in World War I, along with heavy use of large-caliber machine guns. The biggest single cause of casualties in World War I was actually artillery, but combined with wire entanglements, machine guns earned a fearsome reputation.