In the 1990s, Michele had leading roles in two CBS television series: crime drama "Dangerous Curves" (1992–93) and prime time soap opera "Central Park West". She later joined the cast of NBC police drama "" (1998–99) playing Det. Rene Sheppard, and from 1999 to 2002 played Dr. Cleo Finch in the NBC medical drama "ER". She also has appeared in the films "The 6th Man" (1997), "Ali" (2001), "Dark Blue" (2002) and "How to Lose a Guy in 10 Days" (2003). From 2017 to 2018, Michele starred as Ayanna Floyd in the Fox prime time soap opera "Star", and in 2019 she joined The CW prime time soap opera "Dynasty" as Dominique Deveraux.