In the Netflix original television series "Santa Clarita Diet", Barrymore played a real estate agent who, after experiencing a physical transformation into a zombie, starts craving human flesh. Along with co-star Timothy Olyphant, Barrymore served as an executive producer on the single-camera series, which was favorably received upon its premiere; "Rolling Stone" felt that "much of series' laughs comes down to the uncrushable Drew Barrymore charm" and furthermore remarked: "The show is a welcome comeback for Barrymore, the eternally beloved grunge-era wild thing—it's not just her big move into TV, but her first high-profile performance anywhere in years. In a way, it circles back to the roles she was doing in the early , playing deadly vixens in flicks like "Guncrazy" or "Doppelganger"".