On 25 July 2009, Manolev signed a 3+2 years contract with the Dutch club PSV Eindhoven, to fend competitions from Aston Villa. On 6 August 2009, Manolev made his official debut for PSV Eindhoven. He was selected as a starter against Bulgarian club Cherno More in the UEFA Europa League 3rd qualification round. Unluckily for him he was sent off for a second bookable offense in the 44th minute of the game, but his team went on to repeat its 1–0 win from the first leg.