Cuzzi has worked the Wild Card Game in 2013 and the Division Series in 2003, 2004, 2009, 2012, 2015, and 2016. He has umpired in the National League Championship Series in 2005, 2014 and 2019. Cuzzi was also the plate umpire for Game 1 of the 2017 World Series. He also worked the 2008 All-Star Game at Yankee Stadium and the 2019 All-Star Game at Progressive Field in Cleveland. In Game 1 of the 2015 National League Division Series between the Chicago Cubs and St. Louis Cardinals, Cuzzi's wide strike zone was criticized by some Cubs players and media for contributing to their 4–0 loss.