Senai–Desaru Expressway, SDE (Malay: Lebuhraya Senai–Desaru), is an expressway in Johor, Malaysia. It connects Senai in western Johor to Desaru in eastern Johor. Measuring a total length of , it is the third east–west-oriented expressway in the Iskandar Malaysia area after the Pasir Gudang Highway and the Pontian–Johor Bahru Link of the Second Link Expressway. With a new crossing over the Johor River, when opened on 10 June 2011, the expressway shortened travel time from Senai to Desaru from 2.5 hours to one hour.