Unlike the inhibitory GABAergic neurons in the neocortex that only send local connections, in the striatum these neurons send long axons to targets in the pallidum and substantia nigra. A study in macaques showed that the medium spiny neurons have several targets. Most striatal axons first target the GPe, some of these also target the GPi and both parts of the substantia nigra. There are no single axon projections to either the GPi, or to the SN, or to both of these areas; only connecting as continuing targets via axon collaterals from the striatum to the GPe.