After recovery, Griffin signed on to fight pound-for-pound stalwart Anderson Silva at UFC 101. Griffin was slated to take on Brazilian Thiago Silva, but on April 28, 2009, UFC President Dana White confirmed that he would instead accommodate Anderson's return to the light heavyweight division following his middleweight title defense against Thales Leites at UFC 97. During the bout, Griffin was knocked down three times in the first round by Silva. Before the third knockdown, Griffin charged Silva with a flurry of punches, all of which were avoided by sways from Silva, who then countered with a compact right hand whilst retreating, knocking Griffin out.