Tugendhat was educated at King's College School, Cambridge, Ampleforth College and Gonville and Caius College, Cambridge, then took up a career in journalism, becoming a features editor and leader writer for the "Financial Times" from 1960 to 1970. In 1970 he was elected as a Conservative Member of Parliament (MP) for the Cities of London and Westminster, remaining in the House of Commons until 1977, when he resigned after being appointed as a member of the European Commission. He was first appointed to the commission by a Labour government over the head of the nominee of the Conservative leader Margaret Thatcher, but four years later, as prime minister, Thatcher reappointed him, and he served as vice-president of the commission from 1981 until 1985.