Aged 53 years, Amphlett died on 21 April 2013 at her home in New York City after a protracted battle with breast cancer since 2010. Amphlett stated that she had been unable to receive radiotherapy or chemotherapy as treatment for the cancer due to her multiple sclerosis. Amphlett's cousin Patricia Thompson announced the news in an official public statement: "Our beloved Chrissy peacefully made her transition this morning. Christine Joy Amphlett succumbed to the effects of breast cancer and multiple sclerosis, diseases she vigorously fought with exceptional bravery and dignity." In 2014, some of Australia's leading female artists came together to cover "I Touch Myself" to raise awareness and funds for breast cancer.