Multivalent Adhesion Molecules (MAMs) are a widespread family of adhesins found in Gram negative bacteria, including "E. coli", "Vibrio", "Yersinia", and "Pseudomonas aeruginosa". MAMs contain tandem repeats of mammalian cell entry (MCE) domains which specifically bind to extracellular matrix proteins and anionic lipids on host tissues. Since they are abundant in many pathogens of clinical importance, Multivalent Adhesion Molecules are a potential target for prophylactic or therapeutic anti-infectives. The use of a MAM targeting adhesion inhibitor was shown to significantly decrease the colonization of burn wounds by multidrug resistant "Pseudomonas aeruginosa" in rats.