Samuel wrote "Madkhal ila 'al-Talmud" (Hebrew title, "Mevo haTalmud"), an Arabic introduction to the Talmud which is known only through citations from it made by Abu al-Walid, Joseph ibn 'Aḳnin, and Abraham Zacuto. His treatise concerning the hermeneutic rules in the Talmud is known only by name. Some of Samuel ben Ḥofni's teachings, not found in any other sources, have been conveyed in Nathan ben Abraham's Judeo-Arabic Mishnah commentary, supplemented by an anonymous copyist in the 12th-century. The entire work has been translated into Hebrew by Rabbi Yosef Qafih.