Interstate 81 is the main highway providing access to Woodstock. I-81 extends south to Tennessee and north to West Virginia, Maryland, Pennsylvania and New York. Virginia State Route 42 extends southwest from Woodstock into rural southwestern Shenandoah County. SR 42 also connects I-81 to U.S. Route 11, which serves as a local service road for I-81 and is known as Main Street within Woodstock. Route 11 follows the historical route through the Shenandoah Valley, and was once known as the Indian Road and later the Great Wagon Road and the Valley Pike. Route 11 is now the principal local through road connecting towns in the Valley and is dotted with historical markers and scenic points.