In April 2001 Noguchi was assigned to the crew of STS-114 as a Mission Specialist, which at that point the flight was targeting launch to the ISS in 2003 aboard Space Shuttle Atlantis, he was assigned to the crew alongside NASA astronauts Eileen Collins (Commander), James Kelly (Pilot) and Stephen Robinson (Mission Specialist), they were also scheduled to be joined by the Expedition 7 crew, who would remain aboard the ISS, replacing the Expedition 6 crew who would land aboard STS-114.