The squadron was originally activated during World War II as the 561st Bombardment Squadron. After training in the United States, it deployed to the European Theater of Operations, where it participated in the strategic bombing campaign against Germany. The squadron was twice awarded the Distinguished Unit Citation for its combat actions. Following V-E Day, it returned to the United States and was inactivated. The squadron was briefly active in the reserve in the late 1940s, but does not appear to have been fully manned or equipped.