Pozzovivo started the Giro well, avoiding any crashes during the wet opening week and attacking on Stage 9 to Sestola, where he finished third on the day behind the breakaway, taking 30 seconds from his rivals and moving into 4th in the General Classification. He also attacked successfully on Stage 14 to Oropa, but fell ill with Bronchitis on the next day, a mountain top finish at Montecampione, losing time to nearly all his rivals. He managed to recover sufficiently during the rest day to win back time on the remaining peloton on the Queen Stage up to Val Martello on Stage 16, after Nairo Quintana, Pierre Rolland and Ryder Hesjedal had gone away earlier in the stage. He also managed to move up in the overall standings on both Stages 18 and 19, a mountain-top finish and an uphill time trial. He eventually finished in 5th place, his highest ever finish in the Giro up to that point and his first ever top-5 finish in a Grand Tour.