There are several separate strands of narrative following particular characters. James Reedeth is a young psychologist at New York's major mental health institution who is disenchanted with his job and his employer, the revered Elias Mogshack. Lyla Clay is a "pythoness," a young woman capable of metabolising certain psychedelic drugs to enter a trance in which she makes unconscious predictions. Matthew Flamen, a "spoolpigeon" (a variety of investigative journalist), is struggling to hold onto his job, and by his obsessive behaviour has driven his wife into Mogshack's asylum.