In 2006, Hamlin ran Daytona in the Craftsman Truck Series driving the No. 04 Dodge Hemi Dodge for Bobby Hamilton Racing. He also drove the No. 4 Biagi Brothers Racing Dodge in the Daytona Winn-Dixie 250, due to Biagi's driver Auggie Vidovich not having superspeedway clearance. Hamlin also practiced and qualified the No. 41 Ganassi Busch car for several races that Sorenson could not attend due to schedule conflicts with the Cup Series events. During the year, he filled in for teammate Reed Sorenson in 5 non-companion Nextel Cup/Busch Series events, practicing and qualifying Reed's No. 41 Busch car which resulted in two top 5 finishes and three top 10 finishes for Sorenson.