The fort was first established to protect the southern border of the Indian Territory against Spanish colonies to the south. After Indian Removal and the resettlement of the Choctaw in the area, the fort was revived to protect Doaksville, a mile to the west. It became the economic capital of the Choctaw Nation. Fort Towson Landing was located at the head of navigable waters of the Red River. The site was located in Towson County, one of the constituent counties comprising the Apukshunnubbee District of the Choctaw Nation.