Brownsville was a trading center that developed in association with cotton plantations and commodity agriculture in the lowlying Delta of the Mississippi River around Memphis, Tennessee and West Tennessee. It is located north of the Hatchie River, a tributary of the Mississippi, which originally served as the main transportation routes to markets for cotton. The land was developed by planters for cotton plantations, and worked by large numbers of enslaved African Americans, who made up a majority of the town and county population.