She was born in 1885 into a wealthy Jewish family in Rostov-on-Don, Russian Empire. Her mother Eva (born Khave) Lublinskaya was the daughter and granddaughter of rabbis from Yekaterinoslav. Eva trained as a dentist, but did not practise. Sabina's father Nikolai (born Naftul) Spielrein was an agronomist. After moving from Warsaw to Rostov, he became a successful merchant. On her birth certificate, Sabina appeared as Sheyve Naftulovna, but throughout her life and on official documents she used the name Sabina Nikolayevna. She was the eldest of five children. All three of her brothers later became eminent scientists. One of them, Isaac Spielrein, was a Soviet psychologist, a pioneer of work psychology. From her early childhood, Sabina was highly imaginative and believed that she had a 'higher calling' to achieve greatness, and she communicated about this privately with a 'guardian spirit'. However, her parents' marriage was turbulent and she experienced physical violence from both of them. She suffered from multiple somatic symptoms and obsessions.