Acquafresca has been capped for the Italian U-17, U18, U19, U20, and Under-21 sides, making his Italy Under-21 debut in a European qualifying match against Albania on 1 June 2007. The Polish Football Federation, together with Polish national coach Leo Beenhakker, had also tried to convince him to play for Poland. Acquafresca, who speaks Polish, in an interview given to "Gazeta Wyborcza" on 14 March 2008, said that he would leave the decision to the near future. On 18 March, he finally opted to refuse the Polish Football Federation offer, and instead confirmed his choice to represent Italy at international level.