In Rome, SR 27 intersects SR 225. It then joins US 2, enters the town of New Sharon, and intersects SR 134. In Farmington Falls, it intersects SR 41, which heads south. SR 27 then turns onto SR 4 and SR 43. The three routes then turn east toward Industry. SR 27 splits off and heads north into New Vineyard. SR 27 then joins SR 234 before entering New Portland. It then intersects SR 146 and heads north to Kingfield. It intersects SR 142 and joins SR 16. The two routes enter Carrabassett Valley, where they pass Sugarloaf Mountain. The routes then enter Stratton, where SR 16 forks to the west towards Rangeley, leaving SR 27 to head north to Eustis. The highway curves to the northeast to Coburn Gore where it crosses the border into Quebec, continuing as Quebec Route 161.