The amygdala plays a significant role in instigating the emotional reactions associated with anger and violence. With the vmPFC’s outputs to the amygdala, the vmPFC plays a part in preventing such behavior. Evidence has shown that impulsive murderers have decreased activity in the prefrontal cortex and increased activity in subcortical areas such as the amygdala. This imbalance can enhance actions that are created by negative emotions and limit the ability of the prefrontal cortex to control these emotions. Lower activation in the prefrontal cortex is also correlated with antisocial behavior. The dysfunction of the ventromedial cortex seems to, in part, be caused by lower levels of serotonin release.