On April 6, 2016, Martínez became the first player in modern Major League history to hit a pinch-hit home run in his team's first two regular-season games of the season. He was the first player to do so since at least 1914, and the only player to achieve this feat hitting one home run from each side of the plate. On April 20, Martínez recorded his 1,000th career RBI, becoming the fifth Venezuelan-born player in MLB history to reach the milestone.