Grolier later represented the French monarchy in Italy, though claims in older works that he had a formal appointment as ambassador to the Papacy are mistaken. He was Treasurer of War from 1522–31, and after holding regional positions as treasurer he was made one of four Treasurers-General of France in 1537. He had married Anne Briçonnet, from a Tours family, who died in 1545 or so, and they had two daughters at least. He died in Paris and was buried in the Abbey of Saint-Germain-des-Prés, the funeral arranged and the tomb paid for by two daughters and two grandsons.