In the early 1800s, this area was part of the hunting grounds of the Osage nation and other Plains tribes, some of whom had migrated west from other areas. Members of the Cherokee Nation began moving into the area during the 1830s, particularly after Indian Removal by the US government, which forced them on the "Trail of Tears" to west of the Mississippi River, when they were given land by the United States in exchange for their territory in the Southeast. The area was sparsely populated until after the Civil War. The Texas Road and the East Shawnee Cattle Trail, used for cattle drives from Texas, ran through the eastern part of the present-day Craig County.