Past Scarborough Road, the road narrows back to four lanes and passes northeast of the Terry Campus of Delaware Technical Community College. At the West Denneys Road intersection, US 13 leaves Dover and continues past residential and commercial development. To the east of the town of Cheswold, the route crosses DE 42 at Bishops Corner. Following this, the highway heads through a mix of residential development and farmland, crossing Alston Branch before curving north at the point it crosses the Leipsic River to the east of Garrisons Lake. US 13 passes more development and rural areas as it continues north and enters the town of Smyrna. Here, the name changes to South Dupont Boulevard and it runs past businesses as it reaches a ramp to the DE 1 toll road to the east. The road bends to the northwest as it heads to the east of as residential neighborhood and intersects Smyrna-Leipsic Road before passing west of the Belmont Hall State Conference Center. The route crosses Mill Creek to the east of Lake Como and runs through commercial areas in the eastern part of Smyrna. US 13 intersects DE 6, at which point the name becomes North Dupont Boulevard and DE 6 turns north for a concurrency. In the northern part of town, DE 6 splits from US 13 by heading west along DE 300.