The No. 16 ranked Boston College Eagles next faced the Deacons. The Deacons took the lead midway through the first quarter on a 9-yard reverse by Willie Idlette. After a drive that ended on the first play of the second quarter gave the Eagles a 1-yard touchdown run, the Deacons answered later in the quarter with a 46-yard touchdown pass by Skinner. On the Eagles' next drive, quarterback Matt Ryan threw an interception in the endzone that ended their scoring chance. The half ended with the Deacons winning 14–7. On the Deacons first play of the second half, after holding the Eagles on a fourth down attempt, Kevin Marion ran for an 81-yard touchdown. Ryan answered later on a 2-yard scramble to put the Eagles down 21–14 at the end of the third quarter. In the fourth, the Eagles, after missing a 40-yard field goal, forced an interception from Skinner. On their drive, however, after an 11-yard run, L.V. Whitworth fumbled the ball to end the drive. On their last chance in the game, after converting a fourth down, Ryan threw a second interception in the endzone to Patrick Ghee, to seal the win for the Deacons, 21–14. The Deacons beat a ranked team for the first time in nine chances, were 8–1 for the first time since 1944, and tied a school record for wins in a season.