He reached a career high tenth position in the ATP Champions Race in April 2003, as well as a career-high 18th ATP ranking in February 2005. He has career prize money earnings of over $5,000,000. Spadea has ATP career singles wins over Roger Federer (1–2 record), Pete Sampras (1–4), Andre Agassi (2–4), Rafael Nadal (1–1), Andy Roddick (1–2), Patrick Rafter, Richard Krajicek, Yevgeny Kafelnikov, Jim Courier, Michael Chang, Marat Safin, and Gustavo Kuerten. He is one of four players to defeat Federer 6–0 in a set at a main tour tournament, which he did at 1999 Monte Carlo. Spadea represented the United States at the 2000 and 2004 Olympics. Vince was also named twice to the US Davis Cup Team in 2000 (captain John McEnroe) and 2004 (captain Patrick McEnroe).