To begin the 2000 season, Henson sustained an injury in practice that required redshirt-freshman Navarre to start under center against Michigan's first opponent, Bowling Green. In his first career start, Navarre threw for four touchdowns, a school record for a first-time starting quarterback and the most ever in a season opener. The four touchdown passes also tied a school record at the time. Navarre's play in the opener earned him Big Ten Conference Offensive Player of the Week. Navarre continued his role as starting quarterback as Henson continued to be sidelined by injury, getting his second start against Rice. Michigan went on the road against #14 UCLA and lost, 23–20. The following week, Michigan began Big Ten play against #19 Illinois. While Navarre started his fourth game in a row, Henson replaced him late in the first half. Navarre saw limited action at quarterback the rest of the season, ending the season with 583 passing yards and 8 touchdowns in 10 games.