Active in public health, nursing education and other social service, education, and philanthropic work, she succeeded her husband, Chester C. Bolton, in office a few months after his death in 1939. Upon election to the remainder of her late husband's term, Bolton refused the customary widow's allowance comprising the remainder of the salary her late husband would have collected had he served out his term. She represented the 22nd District, mostly consisting of Cleveland's eastern suburbs. Bolton served an additional fourteen terms, serving alongside her son, Oliver P. Bolton, for three of those terms. She and Oliver appeared on "What's My Line?" as the only mother and son serving together. It was reported that when he voted against her, she once stage-whispered, "That's my "adopted" son."