Irvine was appointed manager of Sheffield Wednesday on 8 January 2010. Wednesday got off to a good start under Irvine, winning games against Barnsley, Blackpool and Peterborough United. Irvine was named Championship Manager of the month for January 2010. This form was not sustained, however, as on the last day of the season Wednesday faced a Hillsborough relegation showdown against Crystal Palace who had suffered a 10-point deduction, needing a home win to avoid relegation. The match ended in a 2–2 draw, relegating Wednesday to League One.