In addition to influencing US relations with Africa, another of Bolton's most lasting achievements was sponsoring legislation to purchase property across the Potomac River from Mount Vernon, the home of George Washington. This prevented commercialization of the area and preserved its appearance as it was when Washington lived there. Bolton had a phenomenal relationship with her constituents of Italian-American heritage and was known for mailing government child-care pamphlets to homes where new children were born. The nursing school at Case Western Reserve University is named in her honor for her accomplishments and generosity in the field of public nursing.