Selected by NASA as an Astronaut Candidate in April 1996, Wilson reported to the Johnson Space Center in August 1996. Having completed two years of training and evaluation, she is qualified for flight assignment as a mission specialist. She was initially assigned technical duties in the Astronaut Office Space Station Operations Branch to work with Space Station payload displays and procedures. She then served in the Astronaut Office CAPCOM Branch, working in Mission Control as a prime communicator with on-orbit crews. Following her work in Mission Control, Wilson was assigned technical duties in the Astronaut Office Shuttle Operations Branch involving the Space Shuttle Main Engines, External Tank and Solid Rocket Boosters.