Humphrey's most prominent works include "Color Harmony" (1928), "Water Study" (1928), "Drama of Motion" (1930), and "The Shakers" (1931). "Color Harmony" (1928) was her first independent concert after leaving Denishawn in 1928. She and Charles Weidman presented the work with "Weidman as a slivery figure representing the artistic intelligence that organizes the mingled colors of the spectrum into a harmonious design." "Water Study" (1928) was Humphrey's experiment of dancing without music. She wanted the dancers to move to their natural breathing patterns as they represented the natural movement of water. "Drama of Motion" (1930) was the next step in her experiment of dancing without music. She wanted dance to be an art that could stand on its own without the need of music or emotion and concentrated on the formal elements of movement such as design, rhythm, and dynamics. Her best known work however, brought music and emotion back into play. "The Shakers" (1931) was inspired by a Christian sect known as Shakers. They required members to be celibate and are known for shaking during times of worship. To make sure their members remain celibate they segregate the sexes during rituals. In Humphrey's choreography she incorporates shaking movements to represent their sexual repression as well as the idea of being shaken clean of sin.