During the "Infinite Crisis" storyline, Alexander Luthor Jr.'s incarnation of the Secret Society of Super Villains employs the Brotherhood of Evil to use Chemo as a living weapon by dropping the entity onto the city of Blüdhaven. At the same time in the "" storyline, Batman sees Chemo hit Blüdhaven from a rooftop in Gotham City. After Chemo covers the city with toxic waste, Chemo kills hundreds of thousands of people, but is stopped when Superman throws the entity into deep space.