Potter's most notable role to date was that of Diane Lloyd in BBC medical drama series "Holby City". While researching for the "Casualty" spin off, she witnessed open heart surgery to enhance her role as a medical employee, deeming the experience "fascinating", and stating: "I think I'd have made a good surgeon in real life as I'm very careful and fussy about making my stitches perfect!" On her favourite storyline in the show, she has explained: "Although it was terribly sad, I really enjoyed Steve's departure from the show – the added trauma of the abortion and Diane's relationship with Steve meant that Diane showed some vulnerability – she's usually very strong – and I enjoyed having a good cry. It was also great to be involved in Alex's Parkinson storyline." Of her former cast members, Potter has said: "Everyone is fun to work with here – we're all really lucky to be amongst such lovely people. I work most regularly with Hugh Quarshie who is brilliant so I'm extra lucky." In October 2006, Potter announced her intention to leave the show after four years. "I have really enjoyed and am still enjoying my time on "Holby", I've had some fantastic storylines, but after 4 years on the show I felt it was time to move on to other projects. I wanted to move before I became too complacent. You have to weigh up if it's worth leaving a job that you really enjoy to face the unknown".