McSally endorsed Donald Trump in her 2018 Senate campaign. She opposes same-sex marriage and abortion in "nearly all cases", saying both issues should be decided at a state level. She advocates increased military spending. She opposes and has voted to repeal the Affordable Care Act while supporting the American Health Care Act of 2017. Though criticizing Obama's use of executive action to create it, she supported Deferred Action for Childhood Arrivals until 2018, and has expressed concern about but not opposition to Trump's travel ban and the family separation policy.