The main character, Dr. Bernard Rieux, lives comfortably in an apartment building when strangely the building's concierge, M. Michel, a confidante, dies from a fever. Dr. Rieux consults his colleague, Dr. Castel, about the illness until they come to the conclusion that a plague is sweeping the town. They both approach fellow doctors and town authorities about their theory but are eventually dismissed on the basis of one death. However, as more deaths quickly ensue, it becomes apparent that there is an epidemic. Meanwhile, Rieux's wife has been sent to a sanatorium in another city, to be treated for an unrelated chronic illness.