Combat in "Mother 3" includes a unique musical combo system not seen in previous "Mother" games. When one of the player's characters directly attacks an enemy with a weapon, they can repeatedly attack the enemy by pressing the button in time with the beat of the background music, with each enemy possessing a musical theme with different rhythms. Using this system, the player can attack the enemy up to sixteen times in a row. When the correct beat is not apparent, the player can put the enemy to sleep to isolate the beat from the music.