The street's name is a portmanteau of its two terminating Great Lakes; Huron and Ontario. However, most of the street was alternately named Centre Road, due to its role as a divider for much of its length, and still is today in parts. Within the central part of Brampton, the road is named Main Street. In the Townships of Mulmur and Clearview, the road is bypassed and breaks up and has several names; Centre Road, Lavender Hill Road, and Nottawasaga Concession 8. In addition, two parts form short sections of diagonal roads through this area.