Keothavong had little success during the U.S. Hardcourt Series, but the majority of her successes for 2011 came during the European hard court series towards the end of the year. Keothavong qualified and reached the second round of the Generali Ladies Linz, losing a close match to third seed Jelena Janković. Keothavong then qualified again and this time reached the semifinals of the Luxembourg Open, defeating Ana Ivanovic in straight sets along the way before losing a close match to Monica Niculescu.