Mikayil Mushfig was born in the city of Baku of Baku Governorate in 1908. His father Mirza Abdulgadir Ismayilzade was a teacher and a poet. He lost his parents in early childhood, so was brought up by the relatives. He received his elementary education at Russian-language School in Baku. After the establishment of the Soviet regime in Azerbaijan in 1920, he studied at Baku Teacher's School and in 1931, he graduated from the Department of Language and Literature of the Baku State University. Mushfig married Dilber Akhundzade in 1933.