"Indiana" served in the Spanish–American War (1898) as part of the North Atlantic Squadron. She took part in both the blockade of Santiago de Cuba and the battle of Santiago de Cuba, which occurred when the Spanish fleet attempted to break through the blockade. Although unable to join the chase of the escaping Spanish cruisers, she was partly responsible for the destruction of the Spanish destroyers "Plutón" and "Furor". After the war she quickly became obsolete—despite several modernizations—and spent most of her time in commission as a training ship or in the reserve fleet, with her last commission during World War I as a training ship for gun crews. She was decommissioned for the third and final time in January 1919 and was shortly after reclassified "Coast Battleship Number 1" so that the name "Indiana" could be reused. She was sunk in shallow water as a target in aerial bombing tests in 1920 and her hull was sold for scrap in 1924.