"Miller", assigned to the Pacific in Destroyer Squadron 52 (DesRon 52) throughout her World War II service, departed 20 November 1943, for Pearl Harbor. There she conducted exercises until 22 January 1944, interrupted by an escort mission to Makin. On the 23rd she got underway and sailed west with Task Force 51 (TF 51). For the next month she provided screening and gunfire support services as that force assaulted and occupied Kwajalein and Eniwetok. She departed the latter 24 February for Majuro where she joined the Fast Carrier Task Force (then 5th Fleet's TF 58, later 3rd Fleet's TF 38), with which she operated for the remainder of the war.