Malignant transformations of any or multiple enchondromas are common in patients with Ollier disease and typically emerge in young adults often requiring surgery. The average age of patients of Ollier disease for their first surgery to treat their chondrosarcoma is thirty-three. Some examples of surgical procedures performed to treat secondary malignant bone neoplasms from Ollier disease include amputation, wide-local excisions, hemipelvectomy, and arthroplasty. Cobalt and chemotherapy are typically not primary methods of surgery as chondrosarcomas generally do not have enough blood supply to make it an effective form of treatment. These are done to treat and remove any extraneous bone tissue while preserving the function of limb if possible.