Hupfeld was born in Montclair, New Jersey, the son of Fredericka (Rader), a church organist, and Charles Ludwig Hupfeld. He was sent to study violin in Germany at age 9. Returning to the United States he served in the military during World War I, and he entertained camps and hospitals during World War II. He never wrote a whole Broadway score, but he became known as a composer who could write a song to fit a specific scene within a Broadway show.