In Cass County SR 16 passes through Royal Center and an intersection with US 35. Past Royal Center the route passes through farmland in rural Cass County and through an intersections with SR 17 and SR 25 before leaving Cass County and entering Miami County. In Miami County SR 16 has an intersection with US 31, before SR 16 passes through Denver. Past Denver SR 16 turns north concurrent with SR 19 for about . The concurrency ends with SR 16 turning east while SR 19 continues north. SR 16 crosses over the Eel River as the road leaves Miami County and enters Wabash County.