Mouzon performed with many prominent jazz-fusion musicians. In 1991, he performed with Miles Davis on the movie soundtrack album entitled "Dingo". Mouzon composed the song "The Blue Spot" for the jazz club scene, and appeared as an actor and drummer in the Tom Hanks-directed film, "That Thing You Do" in 1996. Alphonse Mouzon played the role of Miles in the film "The Highlife", which was exhibited at a film festival in Houston in 2003. He also can be seen with Michael Keaton and Katie Holmes in the film "First Daughter", and as Ray in the movie "The Dukes", along with Robert Davi, Chazz Palminteri and Peter Bogdanovich.