Devine encountered early struggles once being called up to the major leagues, becoming the first pitcher in major league history to allow a grand slam in each of his first two games. Braves manager Bobby Cox showed faith in Devine, however, by including him on the postseason roster despite his pitching only five innings with the big-league club during the regular season. In the 18th inning of Game 4 of the 2005 National League Division Series, Devine gave up a walk-off home run to Houston Astros rookie Chris Burke to end the Braves' season.