US 13 leaves the city limits of Wilmington and heads east through commercial areas, with the median turning into a center left-turn lane. The name changes to Governor Printz Boulevard and the route heads into Edgemoor. Here, it crosses Shellpot Creek and widens back into a divided highway, passing between a shopping center to the north and Amtrak's Northeast Corridor to the south before intersecting DE 3, which provides access to I-495. Immediately after, US 13 has a ramp to northbound I-495 and a ramp from southbound I-495. From this point, the route heads between suburban residential areas along with a few businesses to the northwest and I-495 to the southeast, with the Northeast Corridor and the Delaware River on the other side of I-495. US 13 crosses Stoney Creek and passes through Holly Oak before it crosses Perkins Run and reaches Claymont. Here, the route turns northwest away from I-495 and the Delaware River near an overflow parking lot for the Claymont station on SEPTA's Wilmington/Newark Line that runs along the Northeast Corridor, passing homes before it intersects the northern terminus of US 13 Bus. Here, US 13 turns northeast onto four-lane undivided Philadelphia Pike and runs through commercial areas, passing to the northwest of Archmere Academy. The route has an interchange with I-495, at which point it becomes a divided highway, before becoming undivided again as it enters industrial areas. The road passes under an abandoned railroad line in this area. US 13 turns into a divided highway and crosses Naamans Creek before reaching an intersection with the eastern terminus of DE 92 south of the Robinson House. Past this, the road becomes undivided and runs under the Northeast Corridor, gaining a median briefly as it passes under the railroad line, as it heads into Sunoco's Marcus Hook Industrial Complex. Here, US 13 continues into Pennsylvania, where it heads through more of the industrial complex in the borough of Marcus Hook.