Mediate earned his first win since 2002 at the 2010 Frys.com Open by beating Bo Van Pelt and Alex Prugh by one shot. During the tournament, Mediate holed out all four days. He started on Thursday, with a hole-in-one on the 189 yard par-3 3rd hole. On Friday, he holed out from 160 yards on the par-4 4th hole for an eagle, followed on Saturday with a hole-out from 111 yards on the par-5 15th hole, also for eagle. On Sunday, he was tied for the lead on the 17th hole when he holed from 116 yards for eagle to take a two shot lead. He parred the 18th to win the tournament. He also became the oldest wire-to-wire winner on the PGA Tour since at least 1970.