Mofford fought for higher bonding limits and increased funding for mental health programs in Arizona. She strongly opposed English-only instruction in Arizona schools and considered herself an advocate for civil liberties. Known for her fondness for athletics, Mofford created a funding mechanism to keep Major League Baseball's Cactus League in the state. She created the Governor's Alliance Against Drugs, the Governor's Youth Commission Against Drugs, and managed the formation of the state's first Drug Prevention Resource Center. The governor formed a task force to combat the HIV/AIDS epidemic statewide, as a response to its rising national concern; during this time, the HIV/AIDS crisis was an issue thought to be ignored by politicians throughout the country. Mofford tried to increase political leadership opportunities for women in the state, appointing more minorities and women to commissions, boards, and courts than any other past Arizona governor.