Blaine had always believed his health to be fragile, and by the time he joined Harrison's cabinet he truly was unwell. The years at the State Department also brought Blaine personal tragedy as two of his children, Walker and Alice, died suddenly in 1890. Another son, Emmons, died in 1892. With these family issues and his declining health, Blaine decided to retire and announced that he would resign from the cabinet on June 4, 1892. Because of their growing animosity, and because Blaine's resignation came three days before the 1892 Republican National Convention began, Harrison suspected that Blaine was preparing to run against him for the party's nomination for president.