Chemo was originally the nickname given to a plastic vessel used by scientist Ramsey Norton to contain the chemical by-products from his failed experiments. When Norton places the remnants of a failed growth formula in the vessel as his latest contribution, it accidentally brings the man-shaped vessel to life as "Chemo". After killing Norton, Chemo goes on a rampage until stopped by Will Magnus' robot team, the Metal Men. Chemo regenerates and returns, but is defeated each time by the Metal Men.