After this, Keothavong played the Bank of the West Classic in Stanford, California where she lost in the opening round of the singles to Elena Dementieva. Keothavong also played in the doubles with Ayumi Morita against Julie Coin and Marie-Ève Pelletier, trailing 4–6, 5–3 when she attempted to run down a drop shot and, in trying to avoid a collision with the net post, suffered a serious knee injury, rupturing her left anterior cruciate ligament and meniscus, a similar injury to the one she suffered in 2004 in her right knee. This injury ended Keothavong's year and as a result, her year-end ranking dropped to world No. 84.