Piñera is the sixth child of José Piñera Carvallo and Magdalena Echenique Rozas. Among his ancestors on his maternal side is his mother's great-great-grandmother, Luisa Pinto Garmendia, the sister of President Aníbal Pinto Garmendia and daughter of President Francisco Antonio Pinto and Luisa Garmendia Alurralde, who was a descendant of the penultimate Inca emperor, Huayna Capac. He is a nephew of the former oldest living Roman Catholic bishop in the world, Bernardino Piñera, who died in 2020 due to complications from COVID-19.