She was born and raised in Brussels to German parents. Her father, Ernst Albrecht, was one of the first European civil servants. She was brought up bilingually in German and French. She moved to Hanover in 1971, when her father entered politics to become Minister President of the state of Lower Saxony in 1976. As an economics student at the London School of Economics in the late 1970s, she lived under the name Rose Ladson, the family name of her American great-grandmother from Charleston, South Carolina. After graduating as a physician from the Hannover Medical School in 1987, she specialized in women's health. In 1986 she married fellow physician Heiko von der Leyen of the noble von der Leyen family of silk merchants. As a mother of seven children, she was a housewife during parts of the 1990s and lived for four years in Stanford, California, while her husband was on faculty at Stanford University, returning to Germany in 1996.