"Saracen" departed Malta again on 7 December 1942, with orders to patrol off Naples, Italy, then later, eastern Tunisia. On 17 December, she missed the German transport "Ankara" with four torpedoes north of Bizerte, Tunisia. On 22 December, "Saracen" twice sighted the , but failed to manoeuvre into a suitable attack position. "Argento" also sighted the British submarine, but did not attack it because it might have been her sister . "Saracen" ended her patrol on Christmas 1942 in Algiers, where she joined the 8th Submarine Flotilla.