In 1998, Irani appeared in a song ""Boliyan"" of the album ""Saawan Mein Lag Gayi Aag"" with Mika Singh. In 2000, she made her début with TV series "Aatish" and "Hum Hain Kal Aaj Aur Kal", both aired on Star Plus. Apart from this she also acted in Kavita serial on DD metro. In mid-2000, Irani won the lead role of Tulsi Virani in Ekta Kapoor's production "Kyunki Saas Bhi Kabhi Bahu Thi" on Star Plus. She holds the record of winning five consecutive Indian Television Academy Award for Best Actress - Popular, four "Indian Telly Awards." Irani had a fallout with the producer Ekta Kapoor and she left the show in June 2007 and was replaced by Gautami Kapoor. She made her comeback in May 2008 in a special episode, reconciling with Kapoor.