He set up at least 23 factories, that employed around 3000 workers and produced textile, paper, jewellery, tools, furniture, carriages. They used forced labor of the local peasant population. Inspired by the Age of Enlightenment he also opened schools for midwives, physicians, veterinarians, accountants, engineers, even ballet dancers. He also established a botanical garden, theatre, ballet, orchestra and a publishing house. He published the weekly "Gazeta Grodzieńska" from 1775 to 1783. In Hrodna, his main residence and centre of his economic initiatives, Tyzenhaus built 85 structures and planned an entire borough, named Horodnica (derived from "craftsmanship").