With more than 900 journal articles and books, Struve was one of the most distinguished and prolific astronomers of the mid-20th century. He served as director of Yerkes, McDonald, Leuschner and National Radio Astronomy Observatories and is credited with raising worldwide prestige and building schools of talented scientists at Yerkes and McDonald observatories. In particular, he hired Subrahmanyan Chandrasekhar and Gerhard Herzberg who later became Nobel Prize winners. Struve's research was mostly focused on binary and variable stars, stellar rotation and interstellar matter. He was one of the few eminent astronomers in the pre-Space Age era to publicly express a belief that extraterrestrial intelligence was abundant, and so was an early advocate of the search for extraterrestrial life.