There was a substantial demand for Byzantine icons in Europe throughout the Middle Ages and, as a Venetian possession since 1204, Crete had a natural advantage and soon came to dominate the supply. A probable early example is the famous icon of the Virgin in Rome known as Our Mother of Perpetual Help, which was certainly well known in Rome by 1499. At this date there is little to distinguish Cretan work from other Byzantine icons stylistically, and the quality of work is lower than that associated with Constantinople.