On 31 January 1963, "Vampire" departed for her third FESR deployment, which lasted until late July. During this, the destroyer participated in South East Asia Treaty Organisation (SEATO) Exercise Sea Serpent. After returning to Sydney, "Vampire" was taken in hand by Garden Island Dockyard for refit, which concluded in February 1964. During the docking, the ship was awarded the Gloucester Cup for 1963; the third time the award was granted to the ship. After post-refit trials, "Vampire" sailed for her fourth Far East deployment in June, and was involved in Exercise Litgas shortly after reaching the region. From October until January 1965, the ship was involved in the Commonwealth response to the Indonesia-Malaysia Confrontation; carrying out patrols around the Malay Peninsula to interdict vessels smuggling troops into Malaysia. The destroyer remained in South East Asia until January 1965, and returned to Sydney on 12 February.