In New Braunfels, Lindheimer began a friendship with fellow botanical enthusiast John O. Meusebach, who appointed him director of a New Braunfels botanical garden. After resigning as Commissioner-General of the Adelsverein, Meusebach moved from New Braunfels to some acreage he had bought at Comanche Springsin Bexar County, believed to be in the vicinity of current-day Camp Bullis. Lindheimer and Meusebach made botanical collections at Comanche Spring, with Lindheimer's 1849 collections bearing the Comanche Spring place tag. After Meusebach retired to Loyal Valley, Lindheimer was a frequent visitor who exchanged botanical specimens for evaluation with Meusebach.