Based on figures published by the Central Statistical Agency in 2005, this woreda has an estimated total population of 339,981, of whom 171,161 were males and 168,820 were females; 105,929 or 31.16% of its population are urban dwellers, which is less than the Zone average of 32.1%. With an estimated area of 759.53 square kilometers, Shashamene has an estimated population density of 447.6 people per square kilometer, which is greater than the Zone average of 181.7. It is the most densely populated woreda in the Misraq Shewa Zone.