After her term as Lieutenant Governor, Weston spearheaded the most successful fundraising campaign in Canadian cultural history, which raised more than $250 million for the Royal Ontario Museum. She is patron of several organizations dealing with social issues, such as the Abbeyfield House Society, the Hospice Association of Ontario, the Landmine Survivors Network (later known as Survivor Corps), the Ontario March of Dimes, the Prince's Trust Canada and the Yonge Street Mission. Weston also devotes a significant proportion of her time, as well as her business and fashion expertise, to Selfridges, the London department store of which she is a director.