He married Alicia Magdalena Wilson. Their son, Francis Lestock Beaufort (1815–1879) later went out to India and served in the Bengal civil service, from 1837 to 1876. He was for many years judge of the twenty-four Purgunnahs, Calcutta. He was the author of the well-known "Digest of the Criminal Law Procedure in Bengal" (1850), and died in 1879. Beaufort's youngest daughter Emily Anne Smythe was a hero of Bulgaria, a writer, illustrator and advocate of change in the training of nurses.