Protagonist Derrick Cole has developed amnesia from an injection of T'langen, a fluid recovered from Site Zero which was intended to create supersoldiers with T'lan abilities. He is in a recovery facility near Site Zero at the beginning of the war between the humans and Nexus, which overflows into the facility. Derrick is rescued by a mysterious woman named Alex Hendrickson, who seems to know him and is dismayed about his amnesia. As they make their escape, they are separated by an earthquake during an encounter with T'lan warriors. As they go their separate ways, Derrick's new abilities manifest and he is able to break through the T'lan energy shields, much as Alex can. The two eventually reunite and encounter Solus, a human-like T'lan who defeats both Derrick and Alex with ease before running off to complete a different objective.