Brindisi made his debut as a head coach with Club Alumni de Villa María in 1986 his next club was CSD Municipal of Guatemala, which he led to the Liga Nacional de Guatemala title in 1987 and 1988. The next club team Brindisi took charge of was Barcelona Sporting Club in Ecuador where he lad the team to the national championship in 1989 and 1991 and to the Libertadores Cup finals in 1990. He then had spells in charge of RCD Espanyol and UD Las Palmas in Spain. After managing in Guatemala several years he went on to become coach of the Guatemala national team, of which he was in charge during the 1994 World Cup qualification process and on a second tenure in 1997. Brindisi took over at Club Atlético Independiente in the Primera division, he helped the club to win three titles; Clausura 1994, Supercopa Sudamericana 1994 and Recopa Sudamericana 1995. Brindisi then had a spell in charge of his former club and Independiente's fiercest rivals; Racing Club, and a period in charge of Huracán. Brindisi took over at Club Atlético Lanús in 2003, then became manager of Boca Juniors in July 2004, but resigned after only 22 games following a defeat to River Plate. He then became manager of Comunicaciones in 2005.