Since he was a child, Woodring has experienced hallucinatory "apparitions", which have inspired much of his surreal work. He keeps an "autojournal" of his dreams, some of which have formed the basis of some of his comics. His most famous creation is fictional—the pantomime comics set in the universe he calls the Unifactor, usually featuring Frank. These stories incorporate a highly personal symbolism largely inspired by Woodring's belief in Vedanta from Hindu philosophy. He also does a large amount of surrealist painting, and has been the writer on a number of comics from licensed franchises published by Dark Horse and others.