On December 19, 2010, Flynn made his first NFL start, against the New England Patriots, after starting quarterback Aaron Rodgers was not cleared medically to start. Flynn threw three touchdown passes; one each to John Kuhn, James Jones and Greg Jennings against New England, but threw an interception that was returned by Kyle Arrington for a touchdown in the second half. The game went down to the final play when Flynn, with the ball at the New England 15-yard line, lost it when he was sacked. The Packers lost the game 31–27. Flynn completed 23 of 37 passes for 254 yards in the loss.