In 2016, Nancy discovers that Darren and Maxine buried Patrick Blake's (Jeremy Sheffield) body in the City Wall and she agrees to keep it a secret. In April 2016, she along with several other Hollyoaks residents, learn Lindsey was the Gloved Hand Killer. Nancy is now blonde due to Fox's choice to change her hair colour. When Nancy, Darren and Maxine are talking about Patrick’s death they are overheard by someone. This person is thought to be Neeta Kaur (Amrit Maghera) who takes a sudden dislike to Darren, but this is because of Darren grabbing Maxine, it is later revealed that Nico Blake (Persephone Swales-Dawson) was the one who overheard them. In July 2016, after discovering that Warren might know about Patrick's body in the wall, Nancy, along with Darren move Patrick's body into the woods. Darren and Nancy try to get rid of Warren but are almost caught out by DS Gavin Armstrong (Andrew Hayden-Smith). Nancy shouts at Darren for being so stupid with the plan but in the process, accidentally runs over John Paul, making him blind. Nancy later reveals that her leg froze and she couldn't step on the brake, leaving her terrified. In September 2016, Nancy is interviewed over the murder of Patrick, but when she arrives at the school, her leg starts to spasm and she freezes, breaking down in tears, with Louis taking her to the hospital. Nancy along with the rest of the Osbornes flee the village after Jack gets a phone call saying someone is trying to kill him. The person turns out to be Jack's niece Eva Falco (Kerry Bennett) who is after Jack because Jack falsely imprisoned her dad. Nancy starts to feel unwell so Darren takes her to a hospital. The nurse sees a picture of them and calls Eva. When Eva arrives they disappear. On New Year’s Eve they return to the village and Eva holds Nancy, Darren, Jack and Frankie at gun point. Esther, Kim and Grace run in the door and Eva accidentally shoots Esther but she survives.