After US 421, SR 3 leaves Greensburg heading northeast, then just north. SR 3 has an interchange with Interstate 74 (I-74), from US 421. After I-74, SR 3 becomes a two-lane undivided highway. SR 3 has a concurrency with US 52 that lasts for in Rushville. SR 3 heads due north toward US 40 and then SR 3 heads east on US 40 for a short concurrency after . After US 40, SR 3 has an interchange with I-70. Just south of I-70 SR 3 becomes a four-lane divided highway. After I-70, SR 3 passes near New Castle. SR 3 and US 36 have an interchange near Mount Summit. After US 36, SR 3 head north toward Muncie, where SR 3 has an interchange with SR 67.