Wild Weasel operations became the squadron's primary mission in mid-1970, when the squadron exchanged its single seat F-105s for two seat F-105G Thunderchiefs. In April 1972, the squadron established Detachment 1 at Korat Royal Thai Air Force Base, Thailand and flew combat Wild Weasel missions. The detachment was discontinued in September, but crews and planes of the squadron continued to fly missions until late January 1973. The squadron was awarded the Air Force Outstanding Unit Award with "V" Device and the Vietnamese Gallantry Cross with Palm for this period. A plane from the 561st was the last F-105 shot down in the Vietnam War. It was hit by a surface-to-air-missile on 16 November 1972; the crew was rescued. One of the surviving aircraft from the squadron is on display at the National Museum of the United States Air Force with the 561st Squadron's markings.