Moss appeared in the Chuck Wepner biopic "Chuck" (2016), opposite Liev Schreiber. In 2017, she appeared in "Mad to Be Normal", a biopic of the Scottish psychiatrist R.D. Laing, and co-starred in the film adaptation of Anton Chekhov's play "The Seagull" alongside Saoirse Ronan, Annette Bening, and Corey Stoll. The second season of "Top of the Lake", consisting of six episodes, premiered at the Cannes Film Festival in May 2017 which is set in Sydney, Australia. That same year, Moss began playing Offred in the Hulu series "The Handmaid's Tale", for which she has received critical acclaim and a Primetime Emmy Award for Lead Actress in a Drama Series.