In 1995, Eusebio appeared in a career high 113 games for the Astros hitting an all-time best .299 and posting over 100 hits for the only time in his career. For much of the year Eusebio led the Astros in batting average, although his production tailed off in September. Entering the 1996 season, newly acquired catcher Rick Wilkins was expected to get most of the work behind the plate with Eusebio reserved to facing left-handed opposing pitchers. Compounding his diminished role, Eusebio suffered a left-wrist sprain in spring training and later spent over a month on the disabled-list due to a cyst that was surgically removed from this the same wrist. Less than a week after returning to the lineup, Eusebio suffered a broken bone in his left hand and missed another month and a half. Because of his multiple injuries, Eusebio appeared in only 58 games hitting .270.