With the break of the Second World War there was a large influx of Jewish refugees from the west and the number of the Jews in the town at the time of Nazi annihilation was higher than 3,000. Pidhaitsi Judenrat was headed by Leibish Lilienfeld. Due to the refugee and hygienic problems, in the winter of 1941–42 many of town Jews died of hunger and typhus epidemic. In 1942, on September 21 (Yom Kippur – Jewish most revered holiday, the day of atonement from sin) over 1,000 Jews were sent to the Belzec extermination camp and on October 30, 1,500 more Jews were deported to face death in Belzec extermination camp. Hundreds more were murdered in Pidhaitsi and its environs by Germans and Ukrainian police.