Horn signed with the New Orleans Saints in 2000 and ranked in the top ten in receptions (7th), yards (8th) and touchdowns (9th) that year. Given a starting role with the Saints, "Hollywood", a nickname he picked up while with the Kansas City Chiefs for his particular style of dress and a name which carries to this day, quickly proved himself to be a premiere NFL receiver. He was selected to the Pro Bowl four out of his seven years with the Saints, and set single season franchise records for receiving yards (1,399), and receiving touchdowns (11-shared with Marques Colston) as well as the career franchise record for receiving touchdowns (50, a record surpassed by Colston in 2012.). Horn is also the Saints' all-time leader in 100-yard receiving games at 27. Horn had a career year in 2004 with his 1,399 receiving yards being second most in the league. His total was only six yards behind Carolina Panthers WR Muhsin Muhammad. The Saints signed Horn to a six-year contract extension in 2005.