In White County SR 16 crosses over a CSX railroad track before entering Monon. In Monon SR 16 passes mostly houses, before an intersection with US 421. East of US 421 the road crosses another CSX railroad track before passing between North White High School and Monon Elementary School. SR 16 leaves Monon passing through agricultural land in rural White County. The road makes a sharp curve to become north–south before a four-way intersection with SR 39 and 900 North. At this intersection SR 16 and SR 39 head east entering the community of Buffalo. In Buffalo the concurrency turns south and crosses over Tippecanoe River. After the river SR 16 turns east while SR 39 continues south, at this intersection SR 119 begins concurrent with SR 16. SR 16 and SR 119 heads east leaving Buffalo before SR 119 bends north while SR 16 turns south. The road heads south for a mile before a four-way intersection with two county roads, at this intersection SR 16 turns to become east–west. SR 16 leaves White County and enters Cass County.