In the 2010 season, Manningham appeared in all 16 games of the Giants' 10–6 season. In Week 15, against the Philadelphia Eagles, he recorded eight receptions for 113 yards and two touchdowns in the 38–31 loss. The next week, he followed up with four receptions for 132 yards and a touchdown in a 45–17 loss to the Green Bay Packers. In the Giants' final game of the 2010 regular season, he recorded four receptions for 101 yards and a touchdown in a 17–14 win over the Washington Redskins. On the season, he recorded 60 receptions for 944 yards and nine touchdowns.