U.S. Route 15 Business (US 15 Business) is a business route of US 15 through Emmitsburg. Known as Seton Avenue, the highway runs between junctions with US 15 on the south and north sides of the town. US 15 Business follows the original alignment of US 15 through Emmitsburg. The highway serves the St. Joseph's College and Mother Seton Shrine campuses, which are home to several emergency management institutions and a shrine dedicated to Elizabeth Ann Seton, the first person born in the United States to be canonized by the Roman Catholic Church. The U.S. Highway's bypass of the town was constructed between 1963 and 1965. US 15 Business was assigned to the old alignment of US 15 from south of Emmitsburg to the Pennsylvania state line by 1967. The business route became unsigned by 1989 and was truncated at its present northern end by 1999.