"Saracen" was assigned to the British 10th Submarine Flotilla in Malta, and sailed to her new home port on 9 October 1942. The next day, she sighted the surfaced and fired six torpedoes at it, but the U-boat spotted the torpedo tracks and passed between them. The British submarine then surfaced to use her deck gun, but her opponent dived after only three rounds had been fired, and "Saracen" dived. One hour and a half later, "Saracen" surfaced again to signal the presence of the enemy submarine and was spotted by "U-605" which had remained in the area. "U-605" fired four torpedoes at the British submarine, but also missed. The torpedoes were not noticed on board the British submarine, which then received orders to leave the area to allow surface ships to hunt "U-605". Having expended half of her torpedoes, "Saracen" returned to Gibraltar to load new ones, then left for Malta on a different route following the sinking of the submarine on the QBB.255 route. The boat arrived safely in Malta on 19 October.