The title depicts a viral outbreak on a luxurious passenger ship. It introduces an underground organization established to put an end to the global operations of Umbrella, the company responsible for the Raccoon City disaster. Leon S. Kennedy, one of the protagonists of "Resident Evil 2", joined the initiative and received orders to investigate the ocean liner, Starlight, which is rumored to be carrying a new type of bio-organic weapon (BOW) developed by Umbrella. Eventually, the headquarters loses contact with him and Barry Burton, a support character from the original "Resident Evil", is sent in to find his whereabouts.