Om Prakash played the leading man in films like "Dus Lakh", "Annadata", "Charandas" and "Sadhu aur Shaitan". His pivotal roles in the films "Dil Daulat Duniya", "Apna Desh", "Chupke Chupke", "Julie", "Joroo Ka Ghulam", "Aa Gale Lag Jaa", "Pyar Kiye Jaa", "Padosan" and "Buddha Mil Gaya" are considered to be among his best along with Daddu in "Namak Halaal" and De Silva in "Zanjeer". His roles in "Sharaabi", "Bharosa", "Tere Ghar Ke Samne", "Mere Hamdam Mere Dost", "Loafer" and "Dil Tera Diwana" were also appreciated.