Hopkins painted actively during the 1860s and '70s. Her best-known works are several large paintings made from her sketches. She portrayed a voyageur's life in the mid-nineteenth century. Hopkins, however, remained relatively unknown until recently. At the same time, considering that, she was an artist placed in a context where gender-imposed restrictions were prevalent. In fact, Frances Anne Hopkins was dubbed as a woman who "staked out an identity based on difference: a woman in a group of men." Her works were featured at exhibitions of the Art Association of Montreal, followed by, eleven exhibitions at the Royal Academy in London.