Throughout the teens and well into the 1920s, Deiro was a dominant voice of accordion. As Deiro showcased the piano accordion through his vaudeville performances across the United States, more and more people were introduced to the instrument, the popularity of the accordion increased. In 1928, Deiro was featured in an early sound film, Vitaphone #2968, titled "GUIDO DEIRO: The World's Foremost Piano-Accordionist". He appeared as an accordionist in several other motion pictures, such as the musical "Shine on Harvest Moon" and the Carole Lombard comedy "The Other Man".