Adana was a Christian bishopric, a suffragan of the metropolitan see of Tarsus, but was raised to the rank of autocephalous archdiocese after 680, the year in which its bishop appeared as a simple bishop at the Third Council of Constantinople, but before its listing in a 10th-century "Notitiae Episcopatuum" as an archdiocese. The Bishop Paulinus participated in the First Council of Nicaea in 325. Piso was among the Arianism-inclined bishops at the Council of Sardica (344) who withdrew and set up their own council at Philippopolis; he later returned to orthodoxy and signed the profession of Nicene faith at a synod in Antioch in 363. Cyriacus was at the First Council of Constantinople in 381. Anatolius is mentioned in a letter of Saint John Chrysostom. Cyrillus was at the Council of Ephesus in 431 and at a synod in Tarsus in 434. Philippus took part in the Council of Chalcedon in 451 and was a signatory of the joint letter of the bishops of Cilicia Prima to Byzantine Emperor Leo I the Thracian in 458 protesting at the murder of Proterius of Alexandria. Ioannes participated in the Third Council of Constantinople in 680. No longer a residential bishopric, Adana is today listed by the Catholic Church as a titular see.