Karnes served as a member of the United States Advisory Committee on Trade Policy and Negotiations. This committee is appointed by the president and is composed of chief executive officers of 40 of America's largest corporations as well as presidents of key agriculture and labor organizations. The Committee, established by the U.S. Congress in 1974, is the principal trade advisory group representing America's private sector to the president and Congress on all trade issues such as the Uruguay Round of the General Agreement on Tariffs and Trade (GATT), the World Trade Organization, and the North American Free Trade Agreement.