Occupying the extreme eastern position of the blockade, "Indiana" fired at the cruisers "Infanta María Teresa" and "Almirante Oquendo" as they left the harbor, but, due to engine problems, was unable to keep up with the Spanish cruisers as they fled to the west. When the Spanish destroyers "Plutón" and "Furor" emerged, "Indiana" was near the harbor entrance and, together with "Iowa", she supported the armed yacht "Gloucester" in the destruction of the lightly armored enemy ships. She was then ordered to keep up the blockade of the harbor in case more Spanish ships came out and so played no role in the chase and sinking of the two remaining Spanish cruisers, "Vizcaya" and "Cristóbal Colón".