At this point, US 13 and US 40 continues northeast as an eight-lane highway. The road runs through commercial areas, coming to an intersection with DE 273 in Hares Corner. Past this intersection, US 13/US 40 becomes North Dupont Highway and passes between Wilmington Airport to the northwest and businesses to the southeast, reaching a partial cloverleaf interchange with the southern terminus of US 202 and DE 141 at the end of the airport property. Following this, the two routes narrow to six lanes, heading to the northwest of the Main Campus of Wilmington University and running through more commercial areas in Wilmington Manor before passing over the Jack A. Markell Trail and reaching an interchange with I-295, where US 40 splits from US 13 by heading east along I-295 towards the Delaware Memorial Bridge. This interchange also provides access from US 13 to I-95 and I-495 via I-295. Past the I-295/US 40 interchange, the highway passes east of the Delaware Department of Health and Social Services' Herman M. Holloway Sr. Campus and heads through more commercial areas in Minquadale. US 13 reaches an interchange with I-495, with access to and from the northbound lanes of I-495 and from the southbound lanes of I-495. Immediately after this interchange, US 13 Bus. splits from US 13 to head into downtown Wilmington.