Ollier disease carries a higher risk of malignancies such as central nervous system (CNS), ovarian, and adenocarcinoma. Cranial gliomas have been linked with this disorder at an increased rate and at an earlier diagnosis age. A majority of glioma cases contain IDH gene mutations thus explaining the link between the two conditions. Juvenile granulosa cell tumour has also been associated with the disease. One case study indicates that this is due a mesodermal dysplasia in the long bones resulting in ovarian cancer.