Just before his campaign at the US Open, he made an appearance at the last tune-up tournament, the 2010 Pilot Pen Tennis in New Haven, Connecticut. Baghdatis had a chance to win the year's US Open Series if he won this tournament. Appearing as the top seeded player, he beat Igor Andreev for the first time and then came back from a set down to defeat Juan Ignacio Chela to reach the quarterfinals. However, he lost to the eventual champion, Sergiy Stakhovsky on a final-set tie break in the quarterfinals. Arriving at the US Open, he lost in the first round in five sets to Arnaud Clément.