In film, Moss had supporting roles in "Girl, Interrupted" (1999), "Get Him to the Greek" (2010), and "Us" (2019); and starring roles in "The One I Love" (2014), "The Square" (2017), and "The Invisible Man" (2020). She has also starred in three films by Alex Ross Perry, including "Her Smell" (2018). In theater, Moss had roles in the Broadway productions of David Mamet's "Speed the Plow" and Wendy Wasserstein's "The Heidi Chronicles". For the latter, she received a nomination for the Tony Award for Best Actress in a Play. She has also appeared in the West End production of Lillian Hellman's "The Children's Hour".