On October 27, Smith was announced as the starter of the 49ers' game against the Denver Broncos. He became the first black quarterback to start for San Francisco. During this game, Smith ran for one touchdown and threw another in a 24–16 49ers win. Smith struggled early on, passing for just 37 yards in the first half; however he excelled in the second half by going 8 for 10 for 159 yards, and leading the Niners to three fourth-quarter touchdown drives. Smith was named the Sports Illustrated NFL Offensive Player of the week for his performance.