In 1976, the institute was offered a generous donation from Hussain Jamal Foundation. In appreciation of this donation, the institute was renamed as Hussain Ebrahim Jamal Research Institute of Chemistry. In due time, Siddiqui transformed the institute into a distinguished centre of international excellence in the field of chemistry and natural products. In March 1975, he headed the National Commission for Indigenous Medicines His tireless efforts for the promotion of science and technology earned him "Hilal-e-Imtiaz" by the Government of Pakistan in 1980. In 1983, he played a major role in the establishment of the Third World Academy of Sciences and became its Founding Fellow. He remained the director of the Hussain Ebrahim Jamal Research Institute of Chemistry until 1990. Later on, he continued research in his personal laboratory. He published over 400 research papers and was granted 50 patents.