Caltagirone (; ; Latin: "Calata Hieronis") is an inland city and "comune" in the Metropolitan City of Catania, on the island (and region) of Sicily, southern Italy, about southwest of Catania. It is the fifth most populous municipality of the Metropolitan City, behind Catania, Acireale, Misterbianco and Paternò. Alongside Catania, it is the only town who is seat of a tribunal in the former province. Since 1987, the comune has obtained the City title, through presidential act. After Caltanissetta, it is the second most populous comune in Central Sicily.