In January 2017, doctors tell Nancy and Darren that she has multiple sclerosis, leaving the couple devastated. Nancy meets up with an old flame Kyle Kelly (Adam Rickitt) who also has MS. He asks Nancy to hide drugs for him and that they ease the pain of his MS. Nancy agrees but struggles to hide it from her family. When Oscar almost finds them she is horrified, so she takes them to Maxine and Adam Donovan's (Jimmy Essex) engagement party. Darren finds them and they agree to dispose of them. Nancy is emotional when she suffers a tremor and tells Darren that when the MS gets too much, she wants to end her life and she wants him to help her. Darren angrily shouts at her and they argue but they later make up. Darren starts dealing drugs to earn more money to pay for Nancy's treatment. Nancy decides to renew her wedding vows with Darren. Darren disappears after the ceremony and Tom tells Nancy about Darren dealing drugs. When Darren returns Nancy slaps him and confronts him about the drugs. Darren tells his family the truth and a furious Nancy kicks him out. Darren confesses to the police and they charge him. He returns home and Nancy tells him that their marriage is over. Nancy decides not to go to Darren's court hearing. She finds a letter that Darren gave to her and it says how sorry he is and how much he loves her. She runs to the court but Jack tells her it's too late and that Darren has been sentenced to 6 months in prison, devastating Nancy. She later visits him in prison and apologises and they reconcile. Nancy is delighted when Darren is released from prison a few weeks later. Nancy, along with the Osbornes attend Jade's memorial at Hollyoaks High, when and explosion caused by Mac Nightingale (David Easter) tears through the school. Jack helps Nancy out of the building but he is later injured when part of the roof collapses on him. Nancy is devastated when Frankie dies from a stroke.