At the French Open, Baghdatis was beaten by Britain's Andy Murray in the third round in four sets. He suffered a surprisingly poor run in the 2010 grass-court season. He went out in the first rounds in all three grass court tournaments he entered by Philipp Petzschner in Halle, Peter Luczak in s-Hertogenbosch, and Lukáš Lacko at Wimbledon. It was the worst showing he had had in Wimbledon, and even more disappointing as he had a good history record in the past few years there. However, a reshuffle behind the scenes after the grass court season has resulted in Baghdatis once again working with Guillaume Perye.