The road passes through Roann before passing through agricultural land in Wabash County. In rural Wabash County SR 16 has an intersection with SR 15 followed by an intersection with SR 13. Past SR 13, SR 16 leaves Wabash County and enters Huntington County. In Huntington County SR 16 has an intersection with SR 105 before passing through wood and farm land. The SR 16 designation ends at an intersection with SR 5 in rural Huntington County, northwest of the city of Huntington, while the roadway continues east as a county road.