Set near Port St. Lucie, Florida in 2011, the story follows Jotaro Kujo's daughter, Jolyne Cujoh, who is framed for a murder and ends up in Green Dolphin Street Jail. Jotaro soon comes to visit her and informs her that a disciple of DIO's framed her so that he could kill her in prison, and urges her to escape. This plan goes awry when a Stand named Whitesnake uses its power to remove Jotaro's Stand and memories, in the form of discs. Jotaro sinks into a deathlike state, and Jolyne must find a way to recover the discs from Whitesnake's user, the mysterious prison chaplain Enrico Pucci. Along the way, she picks up allies such as Emporio Alniño, a boy born in the prison, Ermes Costello, and Narciso Anasui, who soon falls into unrequited love for Jolyne. Most notable of her allies is Weather Report, an amnesiac who can control the weather. She also meets Foo Fighters (shortened to F.F.), a mass of plankton that had been made sentient via Whitesnake and assumed the human appearance of a recently-deceased female inmate, who later dies at the hands of Pucci.