Ziadeh's first published work, "Fleurs de rêve" (1911), was a volume of poetry, written in French, using the pen name of Isis Copia. She wrote quite extensively in French, and occasionally English or Italian, but as she matured she increasingly found her literary voice in Arabic. She published works of criticism and biography, volumes of free-verse poetry and essays, and novels. She translated several European authors into Arabic, including Arthur Conan Doyle from English, 'Brada' (the Italian Contessa Henriette Consuelo di Puliga) from French, and Max Müller from German. She hosted the most famous literary salon of the Arab world during the twenties and thirties in Cairo.