They were part of the Sandusky Bay Conference and competed in cross country, golf, volleyball, basketball, wrestling, track, softball, and baseball. On March 19, 2013 the Sandusky River League voted 6–0 to accept St. Wendelin as a full-time member. This was a result of the MAL's demise following the 2013–14 school year. The SRL was then absorbed by the SBC for the 2016–17 school year. For one season during the 2016–17 school year St. Wendelin joined the Freelance conference for football only.