SR 8 was one of the original state highways in Ohio. It went from Marietta all the way to Cleveland. Over time, though, parts of the route were renumbered or reassigned, especially in the part south of Akron. In 1926 the portion from Marietta to Newcomerstown became U.S. Route 21. The same year the section from Newcomerstown to Uhrichsville became State Route 16 and SR 8 was rerouted from the Ohio River town of Fly to Uhrichsville. In 1969, the section from Fly to Canton was renumbered to State Route 800, the portion from Canton to Akron was deleted, and the southern end of the highway was truncated at Akron, at U.S. Route 224.