In 1840, he was sent to Lebanon by the American Board of Commissioners for Foreign Missions as a medical missionary for the Dutch Reformed Church, and he was stationed at Beirut, Abeih, Sidon, and Mount Tabor. He studied Arabic in Beirut under Butrus al-Bustani and Nasif al-Yaziji, both of whom later became famous Arab writers, and Yusuf al-Asir, with whom he would later collaborate in translating the Bible into Arabic. He married Julia Abbott, daughter of the former British consul-general in Beirut, in December 1842.