"Vampire" was sent on her sixth Far East deployment in March 1966. In late April, "Vampire" was temporarily withdrawn from Strategic Reserve service to escort "Sydney" on her third Vietnam voyage: the destroyer returned to Hong Kong on 9 May. During late May and early June, "Vampire" participated in SEATO Exercise Sea Imp. On 10 June 1966, "Vampire" collided with the Danish merchant ship "Emilie Maersk" on the Chao Phraya River; the destroyer received only minor damage, and was repaired in Singapore. From July to August, the destroyer was assigned to Tawau to protect the region from Indonesian aggression during the Confrontation. This primarily consisted of using her radar to detect approaching vessels and coordinate interception efforts, although "Vampire" was called on to provide fire support for Commonwealth land forces on two occasions. The ship returned to Sydney on 13 August.