In the Gram-negative bacterium "Escherichia coli" ("E. coli"), cell division may be partially regulated by AI-2-mediated quorum sensing. This species uses AI-2, which is produced and processed by the "lsr" operon. Part of it encodes an ABC transporter, which imports AI-2 into the cells during the early stationery (latent) phase of growth. AI-2 is then phosphorylated by the LsrK kinase, and the newly produced phospho-AI-2 can be either internalized or used to suppress LsrR, a repressor of the "lsr" operon (thereby activating the operon). Transcription of the "lsr" operon is also thought to be inhibited by dihydroxyacetone phosphate (DHAP) through its competitive binding to LsrR. Glyceraldehyde 3-phosphate has also been shown to inhibit the "lsr" operon through cAMP-CAPK-mediated inhibition. This explains why, when grown with glucose, "E. coli" will lose the ability to internalize AI-2 (because of catabolite repression). When grown normally, AI-2 presence is transient.