Drusilla reappears on "Angel" in 2000, when Wolfram & Hart brings her to Los Angeles to re-sire Darla, who had been resurrected as a human dying of syphilis. Drusilla, who loves Darla like a "grandmum," and also more than that, over their 150-year-old complicated relationship, genuinely believes she is doing Darla a favor by siring her and is puzzled by Darla's brief rage before her renewed vampire nature kicks in. Reconciled, the two wreak havoc in the city until Angel sets them on fire. The two go underground to heal, but Drusilla leaves Darla, who is then protected by Lindsey McDonald.