At the Australian Open, Mattek-Sands lost to Agnieszka Radwańska in the first round. In the doubles competition, she reached the third round with Jarmila Gajdošová, before losing to the Indian/Russian pairing of Sania Mirza and Elena Vesnina. In the mixed doubles competition, she and Romanian partner, Horia Tecău finally had their breakthrough moment, defeating title favorites, Bhuphati/Mirza in the semifinals. They then went on to win the title by defeating the team of Elena Vesnina and Leander Paes in the final.