In the fall of 1995, Innes began a recurring role in the second season of the hit NBC medical drama "ER", where she was cast as Dr. Kerry Weaver, the skilled chief of the ER with an abrasive exterior and a physical disability. She was added to the main cast in the third season. In 2001, her character came out as gay during the seventh season. She received two Emmy Award nominations for her role, and three Screen Actors Guild Awards with the "ER" ensemble cast, and has received five nominations for Best Supporting Actress from Viewers For Quality Television. Innes also directed a number of episodes of the series, and episodes of "Brothers & Sisters", "Studio 60 on the Sunset Strip", "House" and "The West Wing", one of which earned her an Emmy nomination for directing.