In 2001, she was picked to play Carmen Lopez on the newly developed ABC sitcom "George Lopez". The show was executive produced by Sandra Bullock and Bruce Helford. After completing its 120th episode, the show reached global syndication and established Lusha as a TV veteran by the age of 20. That following year, the "George Lopez" show won an Emmy and was established as the second-longest-running sitcom in television history to star a Hispanic lead, after "I Love Lucy". To this date, it continues to be Nick at Nite's highest rated series. In 2007, the character was written off the show due to "creative differences".