Joan Wilder is a successful, but lonely, romance novelist in New York City. After finishing her latest novel, Joan leaves her apartment to meet her editor, Gloria. On the way she is handed a letter that contains a map, sent by her recently murdered brother-in-law, Eduardo. While she is gone, a man tries to break into her apartment and is discovered by her apartment supervisor, whom he kills. Returning to her apartment, Joan finds it ransacked. She then receives a frantic phone call from her sister Elaine — Eduardo's widow. Elaine has been kidnapped by antiquities smugglers, cousins Ira and Ralph, and instructs Joan to go to the Colombian coastal city of Cartagena with the map she received; it is Elaine's ransom.