In the 2000s, Biehn took acting roles ranging from big budget films such as "The Art of War" and "Clockstoppers", to video games like "" and independent movies, such as "Havoc". He also starred in three TV series including the CBS drama "The Magnificent Seven" (1998–2000), the Tribune Entertainment syndicated TV series "Adventure Inc." (2002–2003), and the NBC TV series "Hawaii" (2004). All three shows were subsequently cancelled because of low ratings. Biehn was considered to portray Colonel Miles Quaritch, the main antagonist of James Cameron's science fiction epic film "Avatar" (2009), but Cameron felt his appearance in the film coupled with that of Sigourney Weaver's would remind people too much of "Aliens".