Lord Derby married Lady Alice Maude Olivia Montagu, daughter of William Montagu, 7th Duke of Manchester and Louisa von Alten, and step-daughter of the leading Liberal politician Lord Hartington, at the Guards Chapel, Wellington Barracks, London, on 5 January 1889. She was also a lady-in-waiting to her friend, Queen Alexandra. They had three children together. Two of them, Edward, Lord Stanley and Oliver, achieved the rare distinction of sitting in the same Cabinet between May and October 1938 until Edward's death. Their daughter, Lady Victoria, married the Liberal politician Neil James Archibald Primrose and, after his death in World War I, married the Conservative politician Malcolm Bullock.