On September 7, 2014, Anderson made his first start since 2010 after Newton suffered an injury which held him out. In the game, Anderson completed 24 of 34 passes for 230 yards, two touchdowns, and no interceptions, leading the Panthers to a 20–14 victory over the Tampa Bay Buccaneers. Anderson would have his second start of the season after Newton was involved in a car accident, coincidentally also against the Buccaneers. Anderson finished the game by completing 25 of 40 passes for 277 yards, a touchdown, and no interceptions, helping the Panthers win 19–17.