On November 19, 2012, Reyes was traded to the Toronto Blue Jays along with Josh Johnson, Mark Buehrle, John Buck, and Emilio Bonifacio, in exchange for Jeff Mathis, Adeiny Hechavarria, Henderson Álvarez, Yunel Escobar, Jake Marisnick, Anthony DeSclafani, and Justin Nicolino. Reyes needed to be carted off the field during a game against the Kansas City Royals on April 12, 2013, after hearing a pop in his left ankle while sliding into second. Reyes was placed on the 15-day disabled list on April 13. On April 15, general manager Alex Anthopoulos reported that an MRI scan revealed no fracture and that no surgery would be required, but that Reyes was expected to miss three months. On April 15, CBS Sports reported that Reyes's ankle injury was less severe than originally thought, reducing his time on the DL to eight weeks, but that was later refuted by Blue Jays management. He was placed on the 60-day disabled list on April 23 to make room for Aaron Laffey.