iSketch provides word lists in more than twenty languages, multiple difficulty levels, and numerous themes. There are also several game variations, including Blitz (in which the round ends immediately as soon as a player guesses the word), Tandem (where two artists work together), Big Picture (in which two unrelated words must be combined into a single drawing), Connections (where the previous word must be somehow incorporated into the current drawing), and 5 Strokes (where the artist has just five pen strokes to express his/her subject).