US 43 curves to the east and intersects the southern terminus of SR 177 (Commerce Street). It curves to the east-southeast and enters Jackson. It then curves back to the northeast and intersects SR 69. The highway then intersects the northern terminus of SR 177 (College Avenue). Farther into the city is an intersection with the western terminus of CR 10 (Walker Springs Road). The highway curves to the north-northwest and leaves Jackson. It curves to the north-northeast and intersects the southern terminus of CR 3. Then, it intersects the eastern terminus of CR 16 (Toddtown Road). Just before entering Grove Hill, US 43 intersects the northern terminus of CR 29 (Allen Road). On the southern city limits of Grove Hill is an intersection with the southern terminus of SR 295 and CR 18 (Hebron Road). The highway curves to the north-northwest and has an interchange with US 84 (unsigned SR 12; Grove Hill Avenue). US 43 curves back to the north-northeast and briefly leaves the city limits of Grove Hill. On the northern edge of the city limits is an intersection with the northern terminus of SR 295 (North Jackson Street). The highway intersects the southern terminus of CR 17 (Chilton Road). US 43 enters Fulton, where it intersects the western terminus of SR 178. It intersects the eastern terminus of CR 9 and then leaves the town. It then enters Thomasville. It passes Alabama Southern Community College, Thomasville High School, Thomasville Middle School, and Thomasville Elementary School. Farther in the city is an intersection with the eastern terminus of SR 154 (Tallahatta Springs Road). Just before leaving Thomasville is an intersection with the southern terminus of SR 5. The highway winds its way through rural areas of the county and then enters Marengo County.