"Wrangell" conducted three more Mediterranean deployments in the first half of the 1960s and, between those deployments, conducted local operations on the eastern seaboard and into the Caribbean. After successive home-port changes over the years — from New York to Naples to Norfolk to Charleston — "Wrangell" was preparing for her 10th Mediterranean deployment when orders came directing her to sail for the Far East and her first service in the Pacific since World War II. She had been loading ammunition at Earle, N.J., for a week when the message arrived on 28 August rerouting her from the Mediterranean to the Pacific. The ship departed Charleston on 27 September 1965 in response to the critical need in the Southeast Asian area for ammunition ships, in keeping with the escalating nature of the war in Vietnam.