Another son, Albert Gallatin Edwards (1812–1892), was an assistant secretary of the U.S. Treasury under President Abraham Lincoln. In 1887 he founded the brokerage firm A. G. Edwards in Saint Louis, Missouri. A third son, Benjamin S. Edwards (1818–1886), established a successful law practice in Springfield, Illinois and served as a judge in Illinois' Thirteenth Circuit. Ninian Edwards' daughter, Julia Edwards Cook, married Congressman Daniel Pope Cook. Their son, John Pope Cook, was a mayor of Springfield and a general in the Union Army during the American Civil War.