The title track was borne out of a poem Mellencamp's friend George Green wrote as a eulogy he delivered at the grave site upon the death of his grandfather. "He had no intention of using it as a song," Mellencamp said in a 2008 interview with the "Bloomington Herald Times". "He had me read it and I said, 'These are the best lyrics you ever wrote.' He said, 'They're not lyrics' and I said, 'I can make them lyrics.' I took it and kind of cut it up and wrote the chorus." Mellencamp gave additional insight into the writing process of "Human Wheels" in a 2004 American Songwriter interview, saying: "I wrote that song without a guitar or anything. I just sang that melody. I figured out the cadence in my head, and then I went to my guitar to figure out the chords."