On February 5, 2012, Manningham made a catch in the fourth quarter of Super Bowl XLVI to set up the win against the New England Patriots. Trailing by 2 points with 3 minutes and 46 seconds remaining, the Giants started the winning drive. Eli Manning lofted a long pass down the left sideline to Manningham, who kept his feet in-bounds by a fraction of an inch with two defenders around him for a gain of 38 yards. The Giants went on to beat the Patriots by a score of 21–17. Manningham ended the game with 5 catches for 73 yards.