From 2007 to 2008 Cayne played Carmelita Rainer, a trans woman having an affair with married New York Attorney General Patrick Darling (played by William Baldwin), on the ABC prime time drama "Dirty Sexy Money". She had a recurring role as the transgender character Alexis Stone in season six of "Nip/Tuck". Cayne has appeared as a judge and Dean of Dance on "RuPaul's Drag U". As a dance teacher, she taught contestants original choreography to "No Scrubs" by TLC and Kelis's song "Milkshake". In 2011, she guest-starred on the TV show "Necessary Roughness" as Geraldine.