In 2001, Michele played Veronica Porché Ali in the biographical drama film "Ali" opposite Will Smith. She later had two more movie roles: crime drama "Dark Blue" (2002) and romantic comedy "How to Lose a Guy in 10 Days" (2003). She returned to television in 2004, with a starring role in the short-lived UPN legal drama series "Kevin Hill" opposite Taye Diggs. In 2007, she guest starred on "" and in two episodes of "House" as a doctor who had previously worked with the CIA. In 2009 Michele starred in the Hallmark Channel film "Relative Stranger" with fellow "ER" cast member Eriq La Salle. In 2011, Michele had a recurring role on the CW teen drama "Gossip Girl". In the late 2000s and early 2010s, Michele also starred in a number of unsold television pilots.