Almost immediately, US 43 intersects the eastern terminus of CR 4 (Fairford Road). It curves to the north-northwest, leaves Calvert, and travels through rural areas of the county. The highway travels through Malcolm and curves back to the north-northwest before crossing over the Tombigbee River. It then enters McIntosh. The highway intersects CR 35 (John Johnston Road) just before passing Andrews Chapel, a historic log church. The two highways have an unsigned concurrency through the town. US 43 curves to the north and leaves McIntosh. After traveling through some rural areas of the county, it enters Deer Head, where it intersects the eastern terminus of CR 20 (Hawthorne Road). The highway curves to the north-northeast and then curves to the north-northwest before entering Wagarville. There, it intersects CR 6 and then the eastern terminus of SR 56. After beginning a curve to the northeast, it has a crossing of Bassett Creek. The highway curves to the east-northeast, before entering Leroy. It has a very brief unsigned concurrency with CR 34. Then, US 43 passes Leroy High School, curves back to the northeast, and passes the U.S. post office of Leroy. After leaving Leroy, the highway has a second crossing of the Tombigbee River on the Joe C. McCorquodale Bridge. At this crossing, it enters Clarke County.