With the rise of the Catholic Monarchs, the Brethren of the Marshes disappeared, leaving the Coregiment of the Four Villas, which included the whole area of influence of the old Brethren of the Four Villas (almost all of Cantabria). During the "ancien régime", the greatest jurisdictional lordships of Cantabria were mainly under the control of three of the Grandee families of Spain: that of Mendoza (Dukes of Infantado, Marquises of Santillana), of Manrique de Lara (Marquises of Aguilar de Campoo, Counts of Castañeda), and to a lesser extent that of Velasco (Dukes of Frías, Constables of Castile).