As a young girl in Nebraska, Etting had wanted to be an artist; she drew and sketched everywhere she was able. At sixteen, her grandparents decided to send her to art school in Chicago. While Etting attended class, she found a job at the Marigold Gardens nightclub; after a short time there, Etting gave up art classes in favor of a career in show business. Etting, who enjoyed singing in school and church, never took voice lessons. She quickly became a featured vocalist at the club. Etting was then managed by Moe Snyder, whom she married in 1922. Snyder made arrangements for Etting's recording and film contracts as well as her personal and radio appearances. She became nationally known when she appeared in Flo Ziegfeld's "Follies of 1927".