The station affiliated with all four television networks of the "golden age": CBS, NBC, ABC and DuMont. During the late 1950s, the station was also briefly affiliated with the NTA Film Network. In 1969, KNOE installed a translator station on channel 18, K18AB, atop the First National Bank Building in El Dorado to better serve viewers in that area. KNOE-TV continued to air ABC programming until 1972 when KTVE became a primary ABC affiliate and NBC programming until 1974 when KLAA signed-on. During its early years through the 1990s, KNOE, along with Lafayette station KLFY, served the Alexandria and Central Louisiana market as the CBS affiliate on record, as cable outlets in the area largely carried both stations prior to current sister station KALB launching a CBS subchannel in 2007.