In October 2004, Matusow made his first World Poker Tour (WPT) final table at the UltimateBet Aruba Classic, earning $250,000 for 3rd place. In 2006, he finished runner-up to Tony G in the WPT Bad Boys of Poker II in heads-up play. Matusow also appeared in Poker Superstars III, where he made it to the Elite Eight. In the winner-take-all championship match, Matusow beat seven other players to win $500,000. He also appeared in the second, third, fourth, and sixth season of High Stakes Poker. In September 2006, Mike made his debut on the European Poker Tour (EPT) in Barcelona; however, he was eliminated on the first day. In early 2007, Matusow appeared on two episodes of Poker After Dark where he finished 3rd and 2nd respectively. He plays online poker under the following aliases: "dill pickle" (UltimateBet); "mrpokejoke" (PokerStars); and "Mike Matusow" (Full Tilt Poker, where he was formerly a member of "Team Full Tilt").