Frankie Wallace was one of Ambers' most frequent opponents. Wallace fell to Ambers for the last time when he could not return to the ring for the sixth round on December 5, 1938, in Cleveland. In a previous fight in the same city on December 6, 1937, Ambers won in a ten round unanimous decision on a large boxing ticket that featured a crowd of 12,000. With a rapid left and effective right uppercut, Ambers gained a strong points margin, and had an ailing Wallace missing throughout the bout. In their first meeting on April 27, 1933 in Utica, New York, Ambers took a six round points decision.