On television, besides the role of Murdoc in "MacGyver", Des Barres was also a lead cast member of "The New WKRP in Cincinnati" during the 1991–92 season, as part of a husband-and-wife morning team. He had previously appeared on the original "WKRP in Cincinnati" as the lead singer of a punk band, Scum of the Earth. On "Roseanne" he portrayed (Leon's boyfriend) as well as appearing as one of Darlene's baby's doctors on one of the final episodes of the series. Some of his dozens of television appearances include "Seinfeld", "Renegade", "ALF", "Ellen", "Nip/Tuck", "Just Shoot Me!", "Hart To Hart", "My Sister Sam", "Lois & Clark" which reunited him with another "MacGyver" recurring-character alumna, Teri Hatcher, "JAG", "Melrose Place", "Nash Bridges", "Northern Exposure", "Rockford Files", "Sledge Hammer!", "Sliders", "St. Elsewhere", "21 Jump Street", "The Pretender", "Dead Like Me", "Frasier", "Hawaii", "Bones", and "NCIS" in the Season 10 episode "Phoenix".