At the age of 47, Harris was diagnosed with prostate cancer, while making a comeback into the music industry. After being treated for the disease, Harris founded "The Damon Harris Cancer Foundation" in 2001. The organization is a non-profit company, designed to heighten awareness of prostate cancer diagnoses and treatments. The organization has a special focus in reaching African-American audiences, as African-American men have an approximately 60% higher chance of contracting prostate cancer than white men, and are twice as likely to die from the disease.