Keothavong was selected for the British Fed Cup team to play in the Europe/Africa Group 1 match at Eilat, Israel on 1–4 February 2012. In the group stages she played singles, defeating opponents from Portugal, and Israel in the group stages but losing to the Netherlands. The team qualified for a play-off against Austria in which Keothavong beat Patricia Mayr-Achleitner and Great Britain won 2–0 to secure a place in the World Group II play-off to be held in April 2012.