Between Guajará-Mirim and the falls of Teotônio, the Madeira receives the drainage of the north-eastern slopes of the Andes from Santa Cruz de la Sierra to Cuzco, the whole of the south-western slope of Brazilian Mato Grosso and the northern slope of the Chiquitos sierras. In total this catchment area, which is slightly more than the combined area of all headwaters, is , almost equal in area to France and Spain combined. The waters flow into the Madeira from many large rivers, the principal of which, (from east to west), are the Guaporé or Itenez, the Baures and Blanco, the Itonama or San Miguel, the Mamoré, Beni, and Mayutata or Madre de Dios, all of which are reinforced by numerous secondary but powerful affluents. The climate of the upper catchment area varies from humid in the western edge with the origin of the river's main stem by volume (Río Madre de Dios, Río Beni) to semi arid in the southernmost part with the andine headwaters of the main stem by length (Río Caine, Río Rocha, Río Grande, Mamoré).