In 2005, Uribe spent the entire season playing shortstop after the White Sox did not re-sign José Valentín. In 146 games, a number that would have been higher had it not been for minor injuries, Uribe batted .252 with 121 hits, 23 doubles, 16 home runs, and 74 RBIs. In Game 1 of the American League Division Series (ALDS), Uribe hit a home run and had three RBIs as the White Sox defeated the Boston Red Sox 14–2. Uribe made two memorable defensive plays for the final two outs of the 2005 World Series, first catching a ball while crashing into the third base stands and then ranging over the middle and firing an off-balance throw on a slow grounder to beat Houston Astro Orlando Palmeiro to give the White Sox their first title in 88 years.