Isner defeated David Nalbandian in the second round of the 2012 Australian Open in a five-set match, but was defeated in the third round by Feliciano López. He beat world no. 3 Roger Federer in Switzerland in the first round of the Davis Cup, as well as beating Marco Chiudinelli in another singles rubber, to help propel the United States to victory over the Swiss. He then reached the final of the 2012 Indian Wells Masters by beating world no. 1 Novak Djokovic in three sets in the semifinals, before being defeated by Federer in straight sets in the final. Isner also reached the doubles final of the same tournament, partnering Sam Querrey.