Rodriguez has had notable roles in other successful movies, including Letty in "The Fast and the Furious" (2001) and Rain Ocampo in "Resident Evil" (2002). She also appeared in "Blue Crush" and "S.W.A.T." In 2004, Rodriguez lent her voice to the video game "Halo 2," playing a Marine. She also provided the voice of Liz Ricarro in the Cartoon Network series "IGPX." From 2005 to 2006, she played tough cop Ana Lucia Cortez on the television series "Lost" during the show's second season (the character's first appearance was a flashback during the first season's finale, "Exodus: Part 1"), and returned for a cameo in the second episode of the show's fifth season, "The Lie", in 2009. She returned again in the penultimate episode of the series, "What They Died For", in 2010. In 2006, Rodriguez was featured in her own episode of G4's show "Icons."