The Sierra Estrellas were inhabited by the Akimel O'odham people and also some Yavapai bands at the north end of the range at the time of Spanish colonization, and today the mountains tower over several of the Akimel O'odham and Maricopa villages of the Gila River Indian Community. There are petroglyphs throughout the Southern portion of the range. In the colonial era, they were part of the land claimed as New Spain. Occasionally Spanish explorers or priests, most notably Father Kino, would venture near the range to document the area and contact the Akimel O'odham. On his return from the Colorado River in March 1699, Kino climbed a pass through the Sierra Estrellas and saw the Río Salado and Río Verde that he drew on his maps.