The grape is a late budding and ripening variety that is prone to produce high yields if not kept in check by winter pruning or green harvesting. In addition to its susceptibility to numerous grapevine viruses, Agiorgitiko is also very sensitive to fungal infection from botrytis bunch rot, downy and powdery mildew. The vine also responds adversely to water stress which may require some irrigation in regions where the practice is permitted. In order to limit yields, Agiorgitiko is often densely planted in poor vineyard soils but growers need to be mindful of the variety's sensitivity to potassium deficiency.