Greenville has had a high school for 138 years, with the first "Greenville High School" created in 1869. The school was begun under the auspices of Samuel Inglis, who would later become the state superintendent of schools. The first building was torn down and a new Central School erected on Second Street in 1894. By 1915, a new school building was located at Beaumont and Wyatt streets. The current building was constructed in 1956; the former Beaumont building was used as Greenville Junior High after the new high school was built. As the new high school opened, high schools in Pocahontas and Sorento closed and those students began attending GHS.