In 1999, Danny Howells began his "Nocturnal Frequencies" series of mix albums on the record label Obsessive. He also began remixing with Dick Trevor, and the two soon adopted the name "Science Department" for their original productions. Howells continued his live DJing, playing regularly at clubs including Bedrock, Renaissance, Cream, and Ministry of Sound. After the release of his next "Nocturnal Frequencies" album, Howells left Bedrock and Ministry of Sound, taking a residency at Twilo in New York City. After finishing the Science Department track "Breathe", Howells compiled his next mix album "Nubreed 002". The second entry in Global Underground's "Nubreed" series, Howells's album consisted largely of funky, progressive, tech house. Howells was voted number ten of the world's top DJs in DJ Magazine's 2001 Top 100 DJs poll.