Senderos scored in a 4–0 over Atlanta United in the 2018 season opener. However, he picked up a hamstring injury the next week that made him miss 10 games. On 3 July, Senderos scored in the 96th minute to give the Dynamo a 2–2 draw with LAFC. During the next game Senderos got a brace to lead Houston to a 3–0 win over Minnesota United. He would appear in every game of the 2018 U.S. Open Cup as he helped the Dynamo win their first such title in club history. He picked up a hamstring injury in the final that forced him to miss the rest of the season. His contract expired at the end of the 2018 season and the Dynamo decided to not re-sign him.