US 222 in Maryland was widened and resurfaced between what is now the MD 222–MD 275—MD 824 intersection and Port Deposit in 1959 and 1960. US 222 was relocated as part of the construction of its original diamond interchange with I-95 in 1962 and 1963. The old alignment of US 222 east of its I-95 interchange became MD 824. The highway was resurfaced with bituminous concrete from MD 7 to US 40 and reconstructed and widened from US 40 to the southern MD 824 intersection in 1968 and 1969. The widening work included widening US 222's bridge across the Baltimore & Ohio Railroad, which was removed and replaced between 1987 and 1989. The I-95 interchange was converted from a standard diamond to a four-ramp partial cloverleaf with all four ramps east of US 222 between 1993 and 1994.