The Odawa had disputes and warfare with other tribes, particularly over the lucrative fur trade. For example, the tribe once waged war against the Mascouten. In the mid-17th century the Odawa allied with other Algonquian tribes around the Great Lakes against the powerful Mohawk (of present-day New York) and their Iroquois allies in the Beaver Wars. The traditional balance of power in the region had been destroyed by the European introduction of guns and other weapons, changing economic risks and rewards. This disruption produced novel, disastrous, unintended consequences. All indigenous peoples on both sides were disrupted or decimated; some groups, such as the Iroquoian Erie, were exterminated as tribes. By the mid-17th century, the tribes were more severely affected by disease than warfare. Lacking acquired immunity to the new European infectious diseases, they suffered epidemics with high fatalities.