James Moores' land included all of Booneville, extending east across the South Fork River and towards Lerose. The community was originally known as Moore's Station, but it was renamed Booneville (for Daniel Boone) when it was incorporated in 1846. James Moore Jr. was the first postmaster. When the county was formed in 1843, Elias Moore donated the land for its seat. The post office opened in 1844. Owsley County lost part of its territory to Jackson County in 1858, and two years later lost more to Wolfe County. In 1870, Lee County was formed, and Owsley County was reduced to its present size.