On 10 July 2012, Luiz Adriano opened the score in the 2012 Ukrainian Super Cup against cup holders Metalurh Donetsk to help Shakhtar claim the trophy after a 2–0 victory. He netted his first goal of the 2012–13 Premier League season in a 3–0 victory over Karpaty Lviv. He scored the last goal in a 3–1 victory over Dynamo Kyiv on 2 September. He scored the third goal in a 3–0 victory over Zorya Luhansk on 15 September, with an assist from compatriot Willian.