Jesse's backstory is discovered by Gwen while searching files stolen by Cindy Moon's Earth-65 doppelgänger. It is revealed he is the son of two S.H.I.E.L.D. astronaut spies, sent up to the moon to live on a secret base for ten years, during which they gave birth to Jesse. His father turned out to be a Russian double agent, who is then killed by his mother. Joining S.H.I.E.L.D. after high school, Jesse is sent back to the moon to renovate the base where he and his crew were attacked by alien spider creatures. Jesse makes it out alive, but the spider's spit starts poisoning his blood and turning it into black goo. He is saved by the head of S.I.L.K., Cindy Moon, who uses her spider formula to fix his blood and grant him spider powers. She deceives Jesse into thinking he needs two doses of the formula a day to survive, but it is discovered by Gwen that he is already cured and the doses are just maintaining his superhuman powers.