On 10 December 2013, Mohamed was named the new manager of Club América for the Clausura 2014 tournament after the club's President Ricardo Peláez confirmed it during an interview with Univisión. He was officially presented to the press on 17 December. At the press conference it was revealed that he had signed a one year contract with the club, with the potential for an extension pending a review of his performance. Mohamed also spoke of the pressure that came with managing América and comparing it to his time with Club Tijuana, saying, "Here I have everything ["sic"] to lose." His first two signings where Paraguayan center-back Pablo Aguilar, whom he coached while at Tijuana, and Argentine striker Andrés Ríos.