Since 2012 the incidence of neonatal GBS infection has been estimated as 0.53 per 1,000 births in the European region, 0.67 in America, and 0.15 in Australasia. Countries reporting no use of IAP had a 2.2-fold higher incidence of GBS-EOD compared with those reporting any use of IAP. Estimates of the incidence of GBS EOD per 1,000 births differs among countries, Japan 0.09, Panama 0,58, Hong Kong 0,76, and 2.35 in the Dominican Republic. Overall, rates are highest in Africa and lowest in Asia. The estimate of the global incidence of GBS LOD is 0.26 cases per 1,000 live births.