Song made her transition into mainstream film and television from 2010, appearing in the critically acclaimed biographical drama "The Social Network" (2010). She had recurring roles in numerous television series, including the ABC political thriller "Scandal" (2012–13), and the Fox sitcom "New Girl", as well as a starring role on "Dads" (2013). In October 2014, she signed a talent holding deal with Fox and 20th Century Fox Television to star in a future television project. Song was subsequently cast in several television pilots for NBC and CBS, including the CBS medical drama series "Pure Genius" (2016–17), and went on to appear in multi-episode arcs of the action drama series "Station 19" (2018–2020). Since 2019, Song has voiced the lead role of Anne Boonchuy in the Disney Channel animated series "Amphibia" and starred as Madison Maxwell in the Hulu comedy-drama series "Dollface". She also starred in the short indie drama film "First Kiss" (2012), the romantic comedy film "Angry Angel" (2017), the psychological thriller film "Secret Obsession" (2019), and the comedy-drama film "Changeland" (2019).