Wyatt was part of the original cast of the Channel Five soap opera "Family Affairs", playing Samantha Cockerill. Since 2000 she has also appeared in "Casualty" and "Doctors". She appeared in the fifth series of "Peep Show" as Jeremy's mother and recently was Tom's love interest in an episode of "The Old Guys" opposite Roger Lloyd-Pack and Clive Swift. In 2013, she joined the cast of "EastEnders", playing Betty Spragg. She made a second appearance on the BBC series "Doctors" on 19 May 2015 alongside George Layton, another sitcom stalwart from the 1970s.