It is reported that shortly after his arrival to Palencia, he managed, on 25 April 1500, to baptize all the "moriscos" established there. As the 25 April was Saint Marcus day according to the calendar, the then-named "Morería" street has since been known as "San Marcos" street. He was commissioned as Archbishop of Seville on 30 October 1504. But, after the death a few days later of Queen Isabella I of Castile, he had to attend urgent meetings with the other two attorneys of the dead queen, King Consort Ferdinand II of Aragon and Cardinal Francisco Ximenez de Cisneros.