Sproles re-signed with the Eagles on a one-year contract on July 19, 2019. In Week 5, against the Jets He moved into 5th all-time on the all-purpose yards list, passing Tim Brown. However Sproles suffered a partially torn right hip flexor muscle and missed the next three games. He returned in Week 9, but further aggravated the injury. He was later revealed that he fully tore the muscle and was ruled out the rest of the season. He was placed on injured reserve on November 15. On December 21, 2019, Sproles announced that he would retire from the NFL following the 2019 season.