In 2006, Booker finished first on the team in reception yardage and in touchdown receptions with 55 catches for 747 yards and six touchdowns. He had two other receptions for two-point conversions and also has three rushes for 19 yards. His receiving totals were his highest in all three categories since his 2002 season as a member of the Chicago Bears. In addition, his six touchdown receptions is tied for the second highest single season total of his career (along with his six TD catches in 2002 as a member of the Bears), surpassed only by his eight touchdown catches in 2001 with the Bears. Booker because a favorite target of quarterback Joey Harrington later in the season, with four touchdown catches in three games from Weeks 11 to 13. Booker started 14 games during the season and was inactive twice - on December 25 against the New York Jets due to an ankle injury and on October 15 at the New York Jets due to a chest injury.