Chronic stress causes the body to stay in a constant state of alertness, despite being in no danger. Prolonged stress can disturb the immune, digestive, cardiovascular, sleep, and reproductive systems. Other symptoms people may experience include anxiety, depression, sadness, anger, irritability, social isolation, headache, skin problems, menstrual problems, abdominal pain, back pain and difficulty concentrating. Other symptoms include panic attacks or a panic disorder. Chronic stress can increase an individual's risk for psychiatric disorders and some physical disorders such as cardiovascular diseases, high blood pressure, and diabetes.