WSIU-TV operates several UHF translators at the edges of its main coverage area where the station's signal is hard to receive, although it also operates a translator that serves Carbondale. All of these translators map to virtual channel 8 and use the WSIU-TV callsign even though the translators broadcast on different channels. These translators are located in Carbondale (operating on UHF channel 40), Cape Girardeau, Missouri (operating on UHF channel 28), Edwardsville, Illinois (operating on UHF channel 41), and Vienna, Illinois (operating on UHF channel 43).