In 1990, he started the first 3 games before injuring his right thumb against the Chicago Bears. Rich Gannon replaced him while he was out. Wilson returned to action in the second half of the week 15, 13-26 loss against the Tampa Bay Buccaneers, completing 24-of-39 passes for 374 yards, including a career-long 75-yard touchdown pass to Hassan Jones. He started the next game against the Oakland Raiders, completing 11-of-19 passes for 162 yards, one touchdown and one interception, before suffering a separated right shoulder, that forced him to miss the season finale.