When considering physical phenomena, differential equations arise naturally; however, when considering space and time derivatives of functions, it is unclear which reference frame these derivatives are taken with respect to. It is agreed that time derivatives are taken with respect to the proper time formula_60. As proper time is an invariant, this guarantees that the proper-time-derivative of any four-vector is itself a four-vector. It is then important to find a relation between this proper-time-derivative and another time derivative (using the coordinate time "t" of an inertial reference frame). This relation is provided by taking the above differential invariant spacetime interval, then dividing by ("cdt")2 to obtain: