Drew is ostracized by the other residents of Mount Wundagore, the High Evolutionary's New Men, since she was originally human while they were animals. Because of this, she eventually leaves to seek human civilization. She is captured by a HYDRA reserve unit under Count Otto Vermis's leadership who erases her memories, brainwashes her, and recruits her as a HYDRA agent under the codename Arachne. One of HYDRA's top agents, Jared, is assigned to train her in combat and espionage and to seduce her. Once Jessica has become his lover, he allows himself to be captured by S.H.I.E.L.D. so that she can be goaded into assassinating S.H.I.E.L.D. commander Nick Fury.