Isner then accepted a last-minute wildcard to participate in the 2011 Hall of Fame Tennis Championships, replacing compatriot and defending champion Mardy Fish, who was chosen to play in the Davis Cup for the United States during that weekend. Isner was the top seed and defeated Karol Beck, Arnaud Clément, Alex Bogomolov, Jr., and Tobias Kamke without dropping a set, to reach his first career grass-court final. In the final, he defeated Olivier Rochus to become the first top seed in 35 years to win the event. The title was his first of 2011 and second of his career, and ended a three-match losing streak in finals. The championship raised Isner's world ranking from no. 48 to no. 36.