PA 372 was rerouted to its current eastern terminus at PA 82 in Coatesville in the 1940s, replacing the PA 572 designation between Christiana and Coatesville. On August 21, 1968, the Norman Wood Bridge over the Susquehanna River was opened, and PA 372 was rerouted at Bethesda to head over the bridge to its current western terminus at PA 74. Prior to 2007, the intersection of PA 372 and PA 272 in Buck was considered by the "Intelligencer Journal" to be one of the deadliest intersections in Lancaster County due to the number of fatal accidents that occurred there. In 2007, the highways' intersection was moved to a new signalized intersection just south of the original stop-controlled intersection. The project also involved widening existing roads to accommodate the new intersection and allowing only right turns at the original intersection.