Rodionova represented Australia at the Commonwealth Games as the top seed in singles, doubles, and mixed doubles (along with compatriots Sally Peers and Paul Hanley, respectively). In singles, she received a bye into the second round, where she crushed Larikah Russell 6–1, 6–3. Rodionova then defeated Heather Watson 6–0, 6–2. She booked a spot into the final defeating her doubles partner Sally Peers. In the final, after a good start, Rodionova came close to defeat with growing Indian support for the home favourite Sania Mirza, but was able to win in three sets. In doubles, Peers and Rodionova won gold, beating compatriots Olivia Rogowska and Jessica Moore in an all-Australian final. In mixed doubles, Rodionova and Hanley encountered a tough first-round match against Indian pair Nirupama Sanjeev and Rohan Bopanna but ended up winning in three sets. They followed up this win by beating Mhairi Brown and Jamie Murray 6–3, 6–4, and following that, defeated Sarah Borwell and Ken Skupski, earning their place in the gold-medal final match but went down to Scot's Colin Fleming and Jocelyn Rae. Rodionova ended the 2010 season with a ranking of No. 64 in the world.