Bautista was placed on the 15-day disabled list on July 17 with inflammation in his wrist. He had started in all previous 90 games, and the Blue Jays called up prospect Anthony Gose to take his place after the game. Bautista was activated on August 24, but returned to the disabled list on August 26 after he re-aggravated the injury to his left wrist. On August 28, the Jays announced that he would undergo season-ending surgery on the wrist. In 2012, Bautista batted .241 with 27 home runs and 65 RBI in 92 games.