PA 183 enters Upper Tulpehocken Township and heads northwest again through more rural areas of farms and woods as an unnamed road. Farther northwest, the roadway passes northeast of the community of Strausstown, at which point it crosses Old Route 22. Continuing through more of Upper Tulpehocken Township, the route comes to an interchange with I-78/US 22. Past this interchange, PA 183 passes through more areas of farmland and development before curving west into forested areas and crossing Little Swatara Creek into Bethel Township, where it comes to an intersection with the northern terminus of PA 419. Following this, the road heads north and ascends Blue Mountain.