Outside of the village of Cape Vincent, NY 12E loses the Broadway moniker, passing St. Vincent of Paul Cemetery and a mobile home park as it runs northeastward along the St. Lawrence River. About from the village, the route passes an intersection with Carleton Drive, which serves a ferry linking Carleton Island to the river's south bank. After Carleton Drive, the route continues northeast through the town of Cape Vincent, passing another mobile home park and Burnham Point State Park. The route continues on, entering the adjacent hamlets of Sunnybank and Millins Bay. In the latter, NY 12E intersects with CR 7, a riverside highway serving a small community located between the river and NY 12E.