Crossing into the hamlet of Higginsville, where it junctions with the southern terminus of Higginsville Road (CR 50A), NY 46 continues along the former canal, crossing the hamlet of Stacy Basin before turning eastward towards New London. Just west of New London, NY 46 turns northeast a junction with New London Road and crosses the current Erie Canal east of Lock 21. After a short stint north of the canal, NY 46 reaches a junction with NY 49. Running along Rome–New London Road, NY 46 and NY 49 become concurrent through the town of Verona, crossing north of the hamlet of East Verona. Passing south of the Fort Rickey Children's Discovery Zone, the routes cross over Wood Creek and enter the city of Rome.