Mayo Clinic originated with the medical practice of William Worrall Mayo, M.D., (1819–1911). Born near Manchester, England, he was mentored by the eminent British scientist John Dalton and immigrated to the United States in 1846. He worked his way west, earning two medical degrees at a time when formal education for physicians was limited. Dr. Mayo settled in Indiana, and he married Louise Abigail Wright in 1851. They moved to Minnesota Territory in 1854, seeking a more healthful climate. The family relocated within Minnesota several times until Dr. Mayo's appointment as an examining surgeon for the Union Army military draft board during the American Civil War brought them to Rochester. On January 27, 1864, Dr. Mayo advertised in the "Rochester City Post" the opening of a private medical practice "over the Union Drug Store on Third Street" with "all calls answered by day or night".