Devereux Glenholme was established in 1968 on the country estate of the Van Sinderen family, which had been donated to the Devereux Foundation by Jean White Van Sinderen, who had learned of the work of special education pioneer Helena T. Devereux and desired to create a school where children with special behavioral and learning needs could develop their potential. The school's administrative offices are in a colonial revival house originally called Glen Holme, designed by architect Ehrick Rossiter for industrialist William Leslie Van Sinderen (1856–1909) and completed in 1898.