On November 5, Harrison had a standout game on "Monday Night Football" against the Baltimore Ravens. He piled up 9 total tackles, 3.5 sacks, 3 forced fumbles, 1 fumble recovery, and 1 interception. The most memorable moment of the game, however, was Harrison's tackle of Baltimore safety Ed Reed. After a Steelers punt by Daniel Sepulveda, Reed had recovered the kick and was looking to return it. As Reed ran up the sidelines, he was blindsided by Harrison and the ball was knocked away from Reed's grasp. Pittsburgh linebacker Lawrence Timmons immediately recovered the fumble. The Steelers would go on to blow out the Ravens, 38–7.