Following the US Open, Isner participated with Mardy Fish and Sam Querrey in the Davis Cup tie against Colombia, winning the doubles match with Fish as his partner. The United States won the tie 3–1 to remain in the 2011 Davis Cup World Group. Isner was next granted a wildcard to participate at the 2010 China Open, his first time competing in Beijing. In doubles, he teamed with Querrey, losing in the first round to Bob and Mike Bryan. In singles, Isner was unseeded, but made it to the semifinals, before losing to world no. 2 and defending champion Novak Djokovic. Isner next competed at the 2010 Shanghai Masters, where, unseeded, he made it to the second round, losing to world no. 3 and reigning Australian Open champion Roger Federer in their first meeting since the 2007 US Open.