Gandhi started the organisation "People for Animals" in 1992 and it is the largest organisation for animal rights/welfare in India. Gandhi is also a patron of International Animal Rescue. While she is not a vegan, she has advocated this lifestyle on ethical and health grounds. She also anchored the weekly television program "Heads and Tails", highlighting the suffering meted out to animals due to their commercial exploitation. She has also authored a book under the same title. Her other books were about Indian people names. She is a cast member for the documentary "A Delicate Balance".