The magnitude of the effect of interest in the population can be quantified in terms of an effect size, where there is greater power to detect larger effects. An effect size can be a direct value of the quantity of interest, or it can be a standardized measure that also accounts for the variability in the population. For example, in an analysis comparing outcomes in a treated and control population, the difference of outcome means formula_10 would be a direct estimate of the effect size, whereas formula_11 would be an estimated standardized effect size, where formula_12 is the common standard deviation of the outcomes in the treated and control groups. If constructed appropriately, a standardized effect size, along with the sample size, will completely determine the power. An unstandardized (direct) effect size is rarely sufficient to determine the power, as it does not contain information about the variability in the measurements.