On 2 August 2013 it was announced that Crutchlow had signed a two-year deal with the factory Ducati team, to partner Andrea Dovizioso. The beginning of his season was plagued with issues. A malfunctioning transponder caused the electronics of his Ducati Desmosedici to behave strangely during the first race in Qatar, where he finished in sixth place. He experienced tyre issues and later crashed out of the race in Austin. In the crash he suffered a hand injury, causing him to miss the Argentine Grand Prix and thus missing a championship race for the first time in his career. He returned in Jerez, but he was forced to retire after three laps, having experienced problems with the brakes.