There is another Materia Medica with commentaries on a Ruel edition of 1537, printed by Simon de Colines. This work contains hundreds of manuscript marginaia, all along 420 out of 480 pages. The scholar Gonzalez Echeverria demonstrated in the ISHM with a graphological, historical and linguistic study that this task was carried out by Michel de Villeneuve. It also demonstrated that this document was written by the same hand that wrote the famous "Manuscript of Paris", a work also by Michel de Villeneuve, consisting of a draft for his Christianismo Restitutio. "The manuscript of the Complutense" is not just a union of the ideas of the previous works by Michel de Villeneuve, Syropum Ratio, etc., but also of the later works, Enquiridion, De Materia Medica of 1543, sharing with this last many of its 20 big commentaries, for instance.