Liriano got off to a fast start. In his first four 2010 starts for the Twins, he posted a 3–0 W-L record, 0.93 ERA with 27 strikeouts. On May 3, he was named the American League Pitcher of the Month for April, after posting a 3–0 record and leading the league with a 0.96 ERA. Through May 18, he had posted a 4–2 record and a 2.63 ERA in seven starts, striking out 46 in 48 innings and not giving up a single home run.