Just after leaving the inner district of the city of Rome, NY 46 turns northeast at a junction with Elmer Hill Road (CR 60) along parallels the Mohawk River past a local fish hatchery. Crossing the Mohawk, the route soon enters the hamlet of Canterbury Hill and begins running along the eastern shore of the Delta Reservoir. Along one of the branches of the reservoir, NY 46 leaves the city of Rome for the town of Western and passes the entrance to Delta Lake State Park. Continuing northeast along Delta Reservoir, NY 46 soon reaches the hamlet of Westernville, crossing a junction with Gifford Hill Road (CR 53). The route passes Western Town Park and continues out of Westernville and away from the reservoir.