In the season opener against the defending Super Bowl champion New York Giants at MetLife Stadium, Ware recorded two sacks against Eli Manning to reach 101.5 sacks for his career. With these two sacks Ware became the second fastest player (113 games) to reach 100 sacks behind Reggie White (96 games) while also becoming just the 29th player in NFL history to reach 100 or more sacks. At the end of the 2012 season, Ware finished with 11.5 sacks, five forced fumbles and was selected to his seventh Pro Bowl and was named to the Second All-Pro team. Ware was unable to play in the Pro Bowl after his off-season shoulder surgery. He endured a difficult season having to deal with a hamstring he tore in training camp, a fractured right wrist and losing mobility on his right arm in the last three games, because of a hyperextended elbow and a torn labrum that forced him to use an elbow and shoulder harness.