As of the United States 2000 Census, the Census-designated place (CDP) of Hamptonville (ZIP code 27020) had a population of 5,901. It is a Piedmont Triad community. The community is primarily rural and agricultural with many residences scattered across the area. Denser residential and business development is centered on Brooks Crossroads, which is generally the hub of the town as it is just north of US 421 at US 21 and Old Hwy 421 and is the primary route for commuters to work in and out of town and to the elementary school.