The 466th began operations on 22 March 1944 by participating in a daylight raid on Berlin. The group operated primarily as a strategic bombardment organization, attacking such targets as marshalling yards at Liège, an airfield at St Trond, a repair and assembly plant at Reims, an airfield at Chartres, factories at Brunswick, oil refineries at Bohlen, aircraft plants at Kempten, mineral works at Hamburg, marshalling yards at Saarbrücken, a synthetic oil plant at Misburg, a fuel depot at Dülmen, and aero engine works at Eisenach.