Moore dated former "Scrubs" star Zach Braff from 2004 to 2006. In 2008, Moore began dating former Whiskeytown frontman Ryan Adams. They became engaged in February 2009 and married on March 10, 2009, in Savannah, Georgia. In January 2015, Moore filed for divorce from Adams while he was in New York, citing "irreconcilable differences". Moore and Adams later released a joint statement explaining their decision, calling it a "respectful, amicable parting of ways", but in 2019, she called him emotionally abusive. Court documents obtained later revealed that they had been legally separated for nearly six months before the filing. The divorce was finalized in June 2016.