At this point, US 222 splits from PA 741 by turning north to join PA 272 along Willow Street Pike, a one-way pair which carries two lanes in each direction. PA 272 becomes unsigned along the US 222 concurrency. Both directions of Willow Street Pike rejoin and it continues north as a two-lane undivided road past commercial development before it runs through wooded residential areas, passing through Hollinger. US 222/PA 272 crosses Mill Creek and heads through the community of Lyndon. The road briefly gains a center left-turn lane as it continues through wooded areas of development and passes to the west of a golf course. US 222/PA 272 splits into a one-way pair, with two lanes in each direction, and crosses the Conestoga River into Lancaster Township.