From here, US 222 heads north-northeast on four-lane divided Allentown Pike past a few businesses. The route enters Maidencreek Township and narrows to a three-lane road with a center left-turn lane, passing through a mix of fields and woods with some homes. The road curves northeast and passes commercial development, coming to an intersection with PA 73 in the community of Maiden Creek. Past this intersection, US 222 runs past a mix of residential development and businesses with some farm fields. At this point, the route heads into the agricultural East Penn Valley in northeastern Berks County, which is home to an Old Order Mennonite community. US 222 continues northeast through farmland with some trees, residences, and businesses, passing through the community of Kirbyville and crossing into Richmond Township, where the name becomes Kutztown Road. Farther northeast, the road heads past businesses and comes to a roundabout with PA 662 in the community of Moselem Springs. US 222 continues through farmland with some development, passing to the southeast of a golf course in the community of Kempville.