US 701 and US 501 head north on Church Street, a four-lane road with center turn lane, to 16th Avenue, a four-lane street onto which US 701 turns east and runs concurrently with US 501 Business. The concurrency ends at Main Street, where the business route turns south onto Main Street toward downtown and US 701 turns north onto the street, which expands from two to four lanes north of the intersection, to head out of the city. The U.S. Highway parallels the Waccamaw Coast Line Railroad north through the village of Homewood, where the highway meets the eastern end of SC 319 and reduces to two lanes, then gradually splits away from the railroad on its way to a partial cloverleaf interchange with SC 22 (Veterans Highway). At its intersection with SC 410 (Green Sea Road), US 701 veers northeast, has an oblique grade crossing of the railroad, and parallels the rail line to the city of Loris. The U.S. Highway passes through Loris as Broad Street, which intersects SC 9 Business (Main Street). US 701 leaves Loris and parallels the railroad north through a partial cloverleaf interchange with SC 9 to just south of the South Carolina–North Carolina state line.