The chapel is a hidden gem of Roman Mannerism and a major work painter and stuccoist Giulio Mazzoni. It was also called Cappella Santa Caterina «del Calice» or «del Cadice» after the classicising marble statue of Saint Catherine on the altar, the stucco chalices on the spandrels and the title of its patron, Girolamo Theodoli, Bishop of Cádiz. The decoration was originally commissioned by the first owner, Traiano Alicorni in 1555, the work was restarted under a new patron, Girolamo Theodoli in 1569 and finished around 1575.