Speaking for the government, Edward Coke accused him of involvement in every treason since 1586, the year he returned to England. According to Coke, the provincial superior was involved in the Main and Bye Plots of 1603. He had sent Edmund Baynham to Rome to gain papal approval for the 1605 plot, and while at Coughton in November, had prayed "for the success of the great action". Coke called Garnet "a doctor of five Ds, namely, of dissimulation, of deposing of princes, of disposing of kingdoms, of daunting and deterring of subjects, and of destruction". His supposed inappropriate relationship with Anne Vaux was mentioned, but his adherence to the doctrine of equivocation proved extremely damaging. Francis Tresham's deathbed letter, which claimed that Garnet had played no part in the so-called Spanish Treason, was read aloud. Tresham claimed not to have seen Garnet "for fifteen or sixteen years before", despite government evidence that the two had met more recently. Garnet had not seen the letter and did not know that it referred to events before 1602, not 1605. He was unable to explain it, except by saying "it may be, my Lord, that he meant to equivocate."