MacLeod announced her candidacy for the leadership of the Ontario Progressive Conservative party on October 6, 2014, but withdrew on February 6, 2015, following federal cabinet minister John Baird's announcement that he was resigning from cabinet and would not be running for re-election to the House of Commons of Canada. MacLeod told reporters that she has been "under enormous pressure from my constituents to seek the federal nomination to replace John Baird", in the new riding of Nepean. MacLeod decided not to seek Baird's seat in the House of Commons and remained at Queen's Park.