Anne was a descendant of Cicely Wilford and the Most Reverend Dr. Edwin Sandys, an Anglican church leader who successively held the posts of the Bishop of Worcester (1559–1570), Bishop of London (1570–1576), and the Archbishop of York (1576–1588); Sir George Barne III (1532- d. 1593), the Lord Mayor of London and a prominent merchant and public official from London during the reign of Elizabeth I; William Randolph (bapt. November 7, 1650 – April 11, 1711) was a colonist and land owner who played an important role in the history and government of the Commonwealth of Virginia. He and his wife, Mary Isham, are referred to as "the Adam and Eve of Virginia"; Richard Lovelace, an English poet in the seventeenth century and Francis Lovelace (1621–1675), who was the second governor of the New York colony appointed by the Duke of York, later King James II of England.