On 22 September 2010, Hooper made his return from injury in the League Cup, scoring in a 6–0 victory over Inverness Caledonian Thistle. On 25 September 2010, Hooper made his Scottish Premier League debut in a 2–1 victory over Hibernian at Celtic Park. Hooper scored his Scottish Premier League goal on 2 October, in a 3–1 win over Hamilton Academical. and then scored a double against Dundee United at Tannadice on 17 October. One week later, he scored the opening goal in a 3–1 defeat to Rangers at Celtic Park. On 6 November, Hooper and strike partner Anthony Stokes each scored hat-tricks in a league record 9–0 win over Aberdeen. The following week, he scored the winner against St Mirren.