Running east along Main Street, PA 346 reaches the intersection with Davis Street, where it turns north on Davis. Two blocks north, the route turns east again, this time on Forman Street, and crosses the Buffalo and Pittsburgh Railroad's Bradford Industrial Track line. PA 346 reaches an interchange with US 219 and turns north to join the freeway. US 219 and PA 346 run northeast through Bradford, passing through the industrial sector of the city, where it heads over the Buffalo and Pittsburgh Railroad tracks. The highway comes to an interchange with PA 46 (North Kendall Street). The freeway continues northeast through Bradford until PA 346 turns off at an interchange with Bolivar Drive.