In 1809, the Pennsylvania General Assembly authorized for a road between Parkesburg and McCall's Ferry on the Susquehanna River. This road, which ran through the Great Valley, became known as Valley Road or McCall's Ferry Road. When Pennsylvania first legislated routes in 1911, what is now PA 372 existed as a paved road between Quarryville and Georgetown while the remainder of the route west of Quarryville and from Georgetown and Christiana was unpaved. The route was not designated as part of a legislative route. By 1926, the road was paved between Georgetown and Christiana.