Mayfield has performed at Carnegie Hall, Sydney Jazz Festival Australia, North Sea Jazzfestival Europe, and New Orleans Jazz & Heritage Festival. In 2004 Mayfield composed "Strange Fruit", a 90-minute opus based on Billie Holidays recording "Strange Fruit" in 1939. The music combines jazz elements with negro spirituals and classical music. The work is reminiscent of Wynton Marsalis's Blood on the Fields and All Rise, and the storyline features a doomed interracial romance in 1920s Louisiana. The composition was supported by Dillard University.