At the US Open, Bopanna reached the final of a Grand Slam tournament for the first time. Bopanna and Qureshi were seeded 16th and beat the American team of Brian Battistone and Ryler DeHeart in the first round. In the second round, they eliminated Kohlmann and Jarkko Nieminen in straight sets. In the third round, the pair upset the second seeds Daniel Nestor and Zimonjic, again in straight sets. In a highly entertaining quarterfinal, Bopanna's big serves made a difference as they knocked out Wesley Moodie and Dick Norman. In their first semifinal appearance, the duo defeated the Argentine pair of Schwank and Zeballos, still in straight sets. The big-serving Bopanna was spot-on again, as he accumulated one ace after another. Bopanna even pounded an overhead over his shoulder, while retrieved a lob to force an error, causing a commentator to compare it to Roger Federer's between-the-legs winners against Novak Djokovic and Brian Dabul. The ambassadors of India and Pakistan to the US supported the duo at the final. The pair took on the world No. 1 and top-seeded Bryan brothers. The pair lost the final in two closely fought set. Bopanna was exceptional on serve and conjured some high-intensity aces.