According to this theory, in 1554, after the immolation of Michael de Villeneuve/Servetus, the editors and printers that had worked with him would have decided to make a new De Materia Medica as a tribute to their colleague and friend. All the commentaries that could identify Michel de Villeneuve as the author disappeared, but the rest are copied from his work of 1543. It is a very strange edition because there exist four different kinds of copies with different covers, one per editor: Jean Frellon, Guillaume Rouillé, Antoine Vicent and Balthazar Arnoullet, who was also the printer of this unique edition, in Lyons. For developing a bigger work and to blur the mark of Michel de Villeneuve, they hired the expert on De Materia Medica, Pietro Andrea Mattioli.