At St. Charles, IL 64 enters the Chicago metro area and becomes a four-lane road, taking on the name of Main Street. Just east of St. Charles, IL 64 becomes North Avenue and retains this designation until just before its terminus in Chicago at US 41 (Lake Shore Drive). At IL 59, the road widens further from four to six lanes and becomes a divided highway until its intersection with IL 83 in Elmhurst. From Elmhurst to Interstate 294 (I-294) it remains a four-lane surface street, but it widens to a six-lane divided highway once again through the towns of Stone Park and Northlake. At the Des Plaines River and IL 43, North Avenue becomes four lanes until it reaches North Western Avenue. At this point, it becomes at times a two-lane road, for the rest of its route through Chicago. One-half mile (0.8 km) west of US 41, IL 64 turns north onto LaSalle Boulevard, and then east, before terminating at Lake Shore Drive.