Here, PA 372 turns south from Holtwood Road and curves east to PA 272. Eastbound PA 372 turns north for a short concurrency with PA 272 on Lancaster Pike before turning east on Buck Road while westbound PA 372 follows Friendly Drive south and west from Buck Road to PA 272. Upon crossing PA 272, PA 372 enters East Drumore Township and continues northeast along Buck Road through agricultural areas with some woods and residences, passing through the community of Oakbottom. The route makes a sharp turn northwest before immediately turning northeast again before it enters the borough of Quarryville.