US 701 passes by the villages of Bucksport, Bucksville—the site of Hebron Church and Buck's Upper Mill Farm— and Toddville as the highway roughly parallels the Waccamaw River north to Conway. On entering the city limits, the U.S. Highway follows 4th Avenue and expands to a four-lane road with center turn lane. US 701 meets US 501 (Church Street), US 378 (Wright Boulevard), and SC 905 (4th Avenue) at a triangular junction southwest of downtown. US 701 has ramps to and from southbound US 501 just before passing under the highway; southbound US 701 uses the exit ramp from US 501 while northbound US 701 continues to its intersection with US 378. SC 905 begins and heads into the Conway Downtown Historic District while US 701 makes a sharp turn west to join US 378 for a short concurrency to the latter highway's junction with US 501, where northbound US 701 joins the southbound direction and US 501 on Church Street.