The Minnesota Vikings drafted Tarkenton in the third round of the 1961 NFL Draft, and he was picked in the fifth round of the 1961 AFL draft by the Boston Patriots. He signed with the Vikings. Tarkenton, 21, played his first NFL game (and the Vikings' first game) on September 17 against the Chicago Bears, coming off the bench to lead the Vikings to a come-from-behind victory by passing for 250 yards and four touchdown passes and running for another as the Vikings defeated the Bears 37–13. He was the only player in NFL history to pass for four touchdowns in his first NFL game, until the feat was repeated by Marcus Mariota in the Tennessee Titans' 2015 season opener versus the Tampa Bay Buccaneers.