Revered in Bangladesh as the "conscience of the nation", Hossain was compared to Adlai Stevenson by "The New York Times" in 1981. Hossain has been a leading lawyer in the field of human rights, energy law, corporate law and international arbitration. He served on the Iran-United States Claims Tribunal and as UN Special Rapporteur for Afghanistan. Hossain has been a member of tribunals dealing with maritime disputes between Malaysia and Singapore and Guyana and Suriname. He was a two-term member of the UN Compensation Commission. He is a former vice-president of the International Law Association, former president of the Bangladesh Supreme Court Bar Association; and chairman of the Bangladesh Legal Aid and Services Trust and the South Asian Institute of Advanced Legal and Human Rights Studies (SAILS).