The War of the League of Cambrai, sometimes known as the War of the Holy League and several other names, was a major conflict in the Italian Wars of 1494–1559. The main participants of the war, fought from 1508 to 1516, were France, the Papal States, and the Republic of Venice, joined at various times by nearly every significant power in Western Europe, including Spain, the Holy Roman Empire, England, the Duchy of Milan, the Republic of Florence, the Duchy of Ferrara, and Swiss mercenaries.