Keowee () was a Cherokee town in the far northwest corner of present-day South Carolina. It was the principal town of what were called the seven Lower Towns, located along the Keowee River. (Colonists referred to the lower reaches of the river as the Savannah in its lower reaches, with its mouth at the city they named Savannah). Keowee was situated on the Lower Cherokee Traders Path, part of the Upper Road through the Piedmont. In 1752 the Cherokee established New Keowee Town nearby, off the traders path but in a more defensible location.