On 7 August 2017, the Houston Dynamo of Major League Soccer (MLS) announced they had signed Senderos. Senderos made just two appearances in the regular season for a Dynamo squad that finished fourth in the Western Conference. However, injuries to first choice defenders A. J. DeLaGarza and Leonardo opened the door for Senderos to play for Houston in the postseason. Senderos was given the captain's armband by manager Wilmer Cabrera in the second leg of Houston's semi-final matchup away to the Portland Timbers, which Houston won 2–1 to advance to the Western Conference Finals.