The known doses of xylazine that produce toxicity and fatality in humans vary from 40 to 2400 mg. Small doses may produce toxicity and larger doses may be survived with medical assistance. Non-fatal blood or plasma concentration ranges from 0.03 to 4.6 mg/L. In fatalities, the blood concentration of xylazine ranges from trace to 16 mg/L. It is reported that there is no defined safe or fatal concentration of xylazine because of the significant overlap between the non-fatal and postmortem blood concentrations of xylazine.