Starting the 2015 season, much hype surrounded the Eagles signing NFL Rushing Champ DeMarco Murray and San Diego starter Ryan Mathews, leading to speculation that Sproles would get less playing time. In the season opener against the Falcons, Sproles rushed for 50 yards on five attempts and caught seven passes for 76 yards, as well as returning 3 punts for 25 yards. Meanwhile, Murray and Mathews rushed for a combined 11 carries and 13 yards, although they each scored a touchdown rushing while Sproles did not.