Holmes began the season with 2 receptions for 19 yards in a win against the Houston Texans. In the following 10-6 win over the Cleveland Browns, Holmes totaled 94 yards on 5 receptions and had a carry for 10 yards. In the following loss to the Eagles, he recorded 3 receptions for 32 yards. Holmes saw his first score the following week in an overtime win against the Baltimore Ravens, finishing with 61 yards on 3 receptions for a touchdown. Following a bye week, Holmes totaled 89 yards on 5 receptions in the win against the Cincinnati Bengals.