Raymond du Bosc, Lord of La Garénie became co-lord of Assier by marrying a Rigaud: Marguerite of Assier. One of his descendants, Augé du Bosc married Jeanne de Rassiols in 1439, Lady of Vaillac. Their daughter Catherine of Assier married Jean Ricard de Ginouillac in 1464. From their union Jacques Ricard Genouillace called "Galiot de Genouillace" was born in 1465 at the Chateau of Assier who had a brilliant military and diplomatic career. After his death in 1546 his body was repatriated and buried in a chapel of the Church of Assier in 1549. After the death of his son François in 1544 at the Battle of Cérisoles, his daughter Jeanne became his sole heir. She married Charles de Crussols d'Uzes, 9th Viscount of Uzes, in 1523. Widowed in 1543, she remarried the Palatine Prince Philip de Saim called Rhinegrave and converted to the Protestant religion. Their son, Jean de Beaudiné, was invited to the wedding of the future Henry IV and was killed in 1572 during the St. Bartholomew's Day massacre. Twenty years of turmoil shook the region. After the Edict of Nantes, Figeac, Cardaillac, and Assier were governed by the Protestants for 50 years.