"Casino" follows Sam "Ace" Rothstein (De Niro), a Jewish American gambling expert handicapper who is asked by the Chicago Outfit to oversee the day-to-day casino and hotel operations at the Tangiers Casino in Las Vegas. Supporting characters include Nicky Santoro (Pesci), a "made man" and friend of Sam, and Ginger McKenna (Stone), a streetwise chip hustler whom Sam marries and has a daughter with. The film details Sam's operation of the casino, the difficulties he confronts in his job, the Mafia's involvement with the casino, and the gradual breakdown of his relationships and standing, as Las Vegas changes over the years.