Attempts to reduce the presence of the fungus have been employed, however, Cercospora sojina still remains a threat to farmers. Resistance to fungicide has already occurred in 13 U.S. states at the end of 2016. New versions of the fungal genome have also been observed across the U.S, Brazil, China and other regions where soybeans are grown that have varying virulence and resistance levels (Lin and Kelly, 2018; Gu et al., 2020). Warmer winter temperatures have been suggested as a possible contributor to an increase in Frogeye Spot disease as well as susceptible soybeans and conservation tillage. If leftover residue from infected plants is not removed and crop rotation does not occur, the fungus will continue to develop into the next growing season.