After the events of "Crisis on Infinite Earths", Doctor Poison was a founding member of Villainy Inc., but the team was created by Queen Clea instead of Eviless. As part of Villainy Inc., Doctor Poison battled Hippolyta, the first Wonder Woman, in the 1940s. It was later revealed by her granddaughter that she had died after creating the Reverso drug, as she accidentally reversed her own growth patterns and had forgotten the antidote by becoming too young too fast, eventually reverting to a fetus and then nothing.