In 2009, just before his fight with Shane Mosley, Margarito was involved in an incident where he was caught with illegal hand wraps containing gypsum (calcium sulfate) which, when combined with moisture, forms plaster of Paris. His signature stoppage victory over Miguel Cotto in 2008 was subsequently called into question. Following consecutive losses to Manny Pacquiao (a fight in which Margarito sustained career-changing eye damage) and a rematch against Cotto, Margarito retired from boxing in 2012 but returned for three more fights between 2016 and 2017.