After several failed Hydra campaigns, including the failure of the world blackmail attempt using the Betatron Bomb, the creation of the Overkill Horn (designed to detonate all nuclear explosives worldwide), and the bio-engineered "Death-Spore" Bomb, which led directly to Strucker's first death at the hands of Fury, and several deceived Hydra operatives. In the wake of Strucker's first death, the surviving elements of Hydra broke into factions that each adopted its own reorganized modus operandi. Several of these factions developed "super-agents" that would occasionally break away in turn to become freelance operatives, or, in some rarer cases, superheroes such as the first Spider-Woman. During this era, Hydra's collective threat is mitigated by not only occasionally infighting among themselves, but their operating policy of punishing failure with death, often led to their killing of each other more often than their intended victims. Hydra frequently found itself defeated by S.H.I.E.L.D., various superheroes, and even apparently unpowered civilians, like the motorcycle racing team, Team America. Strucker is revived, and he reunites several of the Hydra factions under his leadership, renewing his campaign against S.H.I.E.L.D. and humanity for several more years.