Lowe has worked with many leading directors including Bill Alexander, Alan Ayckbourn, Annie Castledine, Jonathan Chadwick, Anthony Clark, Stephen Daldry, Alan Dossor, Richard Eyre, Bill Gaskill, David Leveaux, and Danny Boyle, who early in his career was assistant director on Lowe’s play "Tibetan Inroads". His theatre and television work has featured actors such as Bruce Alexander, Warren Clarke, George Costigan, Kenneth Cranham, Sharon Duce, Emma Fielding, Brian Glover, Nigel Hawthorne, Bill Paterson, Neil Pearson, Kathryn Pogson, Linus Roache, Colin Tarrant, Marjorie Yates, Harriet Walter and Rachel Weisz.