At the summit of Blue Mountain, PA 183 widens into a four-lane divided highway, crossing the Appalachian Trail and entering Wayne Township in Schuylkill County, The route descends the mountain and becomes a three-lane undivided road with two southbound lanes and one northbound lane. The road narrows to two lanes and continues north through wooded areas with some farm fields and residences, coming to an intersection with PA 895. The route heads through more rural areas with some homes, passing through Reedsville. PA 183 comes to a junction with PA 443 and heads northeast through more farms, woods, and homes. The route crosses into North Manheim Township and becomes Chestnut Street, where it curves to the east. The road passes through more rural areas, becoming the border between the borough of Cressona to the north and North Manheim Township to the south before fully entering Cressona.