By the early 1930s the road then signed as US 22 became problematic for motorists in Lebanon along the current US 422; Reading via US 22 and US 222; and Allentown on Hamilton Street (US 22). PA 43 had been aligned as a bypass between Allentown and Harrisburg. On June 8, 1931, the American Association of State Highway Officials came to a resolution to the traffic problem, by replacing the PA 43 corridor with US 22 and the William Penn Highway name to match. The state truncated PA 43 to Susquehanna Street from Allentown to Bethlehem. US 222 replaced the former US 22 alignment from Reading to Allentown. Hamilton Street was numbered as US 222, west of Center City Allentown, where it turned north onto 15th Street. This portion of US 222 was seven-blocks long which ended at Tilghman Street (then US 22). Signs were changed to reflect the new designations on May 31, 1932, with the new route designations officially in place on June 1, 1932.