Arquette appeared in the Sega video game "ESPN NFL 2K5", voicing himself as a "celebrity adversary" and manager of his own team, the Los Angeles Locos, as well as appearing as an unlockable character in Season Mode. He also appeared in the 2001 EA video game "SSX Tricky", as the voice of lead character Eddie. He also starred in "See Spot Run" in 2001. Arquette starred in the 2007 ABC comedy series "In Case of Emergency", which was canceled after one season. Since then, he has appeared in the 2008 film "Hamlet 2" and reprised his role in "Scream 4", again acting alongside Cox. He appeared alongside his sister in the TV show "Medium" in January 2011.