In a Week 1 Super Bowl 50 rematch against the Carolina Panthers, Ware recorded a team leading 1.5 sacks and helped the Broncos beat the Panthers by a score of 21-20. In Week 2 against the Colts, Ware left the game with an apparent arm injury as he was trying to bring down quarterback Andrew Luck. It was eventually revealed that there was an ulna fracture near the elbow. The injury required surgery with 4–5 weeks to recover. Ware went on to play 10 games recording four sacks before having season-ending back surgery on December 28, 2016.