The Chameleon's most ambitious play against Spider-Man happened when he formed an alliance with Harry Osborn as the Green Goblin. Before Harry's death, the Chameleon was told Spider-Man's secret identity could be found through Peter Parker, to construct androids of Peter's parents; the Chameleon later admitted that he went through with the plot to confirm once and for all that Peter was Spider-Man. The plan led to a psychotic breakdown for both Spider-Man and the Chameleon, Spider-Man briefly renouncing the civilian identity while the Chameleon is sent to Ravencroft Asylum. But when Doctor Ashley Kafka sneaks him into a basement to try to continue treating him in the belief that he was close to a breakthrough when the court were preparing to put him on trial, the Chameleon escaped and attempted to convince Spider-Man of actually a hallucinating writer who had suffered a mental breakdown after his daughter's death in a car accident but Peter managed to break through this deception due to his own strength of will. The Chameleon's confirmation of Spider-Man's secret identity led him to try to attack Spider-Man through family and friends but this effort met with rather dismal results when Mary Jane Watson subdued him with a baseball bat. Somewhere in between this and subsequent appearances, he appeared to have been destroyed by his nephew Alyosha Kravinoff; Alyosha later threw a Chameleon mask at Spider-Man's feet, referring to it as 'That weakling Dmitri' but apparently recovered, waking in a hospital.