Stationed out of Norfolk, Virginia, "Comfort" operates primarily in the Caribbean and Latin America. Her first mission was a combat one: serving coalition troops off the coast of Kuwait, during Operation Desert Storm. Her first humanitarian missions both happened in 1994, helping Haitian and Cuban immigrants looking to come to America. In the aftermath of 9/11, "Comfort" was activated and sent to Manhattan, to provide medical and mental health services. "Comfort" headed into combat again for Operation Iraqi Freedom. In 2005, she was back saving American citizens following the devastation of Hurricane Katrina. In 2010, she undertook another disaster relief mission, in response to an earthquake in Haiti. In May 2015, "Comfort" was in Kingston, Jamaica, providing medical services including optometry, dentistry, general medical, women’s health, pediatrics, and pharmacy. The Jamaica leg was part of ‘Continuing Promise’, a nearly six-month humanitarian mission across the Caribbean region. Once again in 2017, "Comfort" was deployed to aid American citizens in Puerto Rico after Hurricane Maria.