In the center of East Nassau, NY 66 reaches a junction with the terminus of CR 26 (Garfield Road). Near the junction with Tsatsawassa Lake Road, NY 66 leaves Kinderhook Creek behind permanently, continuing north through the town of Nassau, past Tackawasick Lake and the Tackawasick River before reaching the hamlet of Hoag Corners, where it reaches a junction with CR 16 and CR 21 (Dunham Hollow Road). Crossing the Tackawasick River, NY 66 continues north out of Hoag Corners and past Pikes Pond. At the northern end of Pikes Pond, NY 66 reaches a junction with CR 20 (Totem Lodge Road). Just north of that junction, the route enters the hamlet of Denault Corners, where it meets with NY 43.