In 1484, Cereta got married at age fifteen to Pietro Serina. Serina was a business merchant from Venice, yet had the same interests in academia. Difficulties between the two emerged in their marriage. In her letters to him, she wrote “You charge me with laziness and attack me for my long silence as though I were a defendant in court. You act as if I were the sort of person who would write to strangers and only neglect you, as though I were forgetful of you when in fact I accord you a place of honor above that of other learned men.” Despite the arguments, for Cereta, this was one of the happiest moments in her lifetime. In her letters, she imagined an ideal marriage as a partnership overseen by mutual honor, respect, honesty, and love. Cereta never regarded one's marriage as a kind of friendship, nor did she ever directly call her husband a friend. Nonetheless, in her letters, the languages of marriage and friendship were clearly delineated, focusing the readers' attention upon the reciprocal relations like mutual love, communication. She often focused the readers' attention on mutual relations such as love, communication and responsibility that manage both spousal and friendship. After eighteen months of marriage, her husband died due to a plague. The two had no children and she never remarried.