Pennsylvania Route 181 (PA 181) is a north–south state route in York County in south central Pennsylvania. Its southern terminus is at Interstate 83 Business (I-83 Bus.) and U.S. Route 30 (US 30) in North York. Its northern terminus is at the southern terminus of PA 382 in York Haven. PA 181 heads north from US 30 as a four-lane divided highway concurrent with I-83 Bus to an interchange with I-83, where I-83 Bus. reaches its northern terminus. From here, PA 181 continues north as a two-lane undivided road through suburban areas, intersecting PA 238 in Emigsville and PA 921 in Manchester. The route runs through rural land before it comes to York Haven.