On September 25, 2017, it was revealed that Sproles suffered a broken arm and a torn ACL on the same play in a game against the New York Giants in Week 3. He was officially placed on injured reserve that day, prematurely ending his season. In three games, he rushed 15 times for 61 yards with seven receptions for 73 yards. The Eagles went on to win Super Bowl LII. After the season ended, Sproles stated his interest to return to the Eagles for one more season.