When his half-brother committed suicide, the Chameleon became obsessed with making Spider-Man suffer for his failure to prevent this. He ingested a serum which made his face permanently featureless and malleable. He attempted to kidnap America's leading expert on superconductors, but was thwarted by Spider-Man. He then kidnapped J. Jonah Jameson. He approached the Maggia for support to be New York's new crime lord, and formed an alliance with Hammerhead. Disguised as a scientist, the Chameleon temporarily removed Spider-Man's powers. He allied himself with the Femme Fatales, the Scorpion, and the Tarantula to eliminate Spider-Man and the Black Cat, but escaped when his plan failed.