PA 150 intersects PA 550, with that route forming a concurrency with PA 150, heading into the borough of Bellefonte. The road becomes South Water Street and passes residences and a few businesses, crossing a Nittany and Bald Eagle Railroad line and curving to the north. PA 550 splits from PA 150 by heading east on West High Street, and PA 150 continues through more commercial areas along the east bank of Spring Creek on North Water Street. The route comes to an intersection with PA 144, where that route turns north to join PA 150, with the road heading north into areas of homes and businesses. PA 144/PA 150 enters Spring Township again and becomes Pleasantview Boulevard, heading into wooded areas with some commercial development, curving to the northeast before heading to the northwest. The road passes through a gap in forested Bald Eagle Mountain and crosses into Boggs Township, turning to the north again. PA 144/PA 150 heads into the borough of Milesburg and becomes Turnpike Street, passing homes. The two route turn northwest onto Mill Street and pass businesses, crossing Bald Eagle Creek. Past this, the road becomes a divided highway, soon widening to four lanes as it crosses over a Nittany and Bald Eagle Railroad line and comes to an interchange with US 220 Alternate.