Archaeological digs have uncovered items from the Roman era in Breno. The village name is Celtic in origin, though the exact meaning is unknown. At some time after the year 1000, the Abbey of S. Abbondio in Como acquired some rights and land in Breno. The municipality bought itself out from under those rights in 1579. Modernly, the village includes the south land that once belonged to the municipality of Tortoglio. This land was abandoned in the wake of a plague in the 15th century. The village was involved in a land dispute with Miglieglia until 1890.