Five years later, the Punisher hunts for the first known infected, Spider-Man in a New York City that has been depopulated. Castle is constantly bugged by a cannibalistic Deadpool, who he has killed over 35 times. While out on patrol, Frank encounters an elderly priest and a young boy who have been surviving in the ruins of New York. While the Priest attempts to appeal to Franks humanity in hopes that the infected can be saved, Frank coldly tells him that the only way to win is to kill them all.