PA 372 was designated in 1928 to run from McCall's Ferry, where a ferry crossed the Susquehanna River to York County and connected to an unpaved road leading to PA 74 in Kyleville, east to PA 41 (Newport Avenue) in Christiana. The route followed Pinnacle Road and Holtwood Road to Holtwood, its current alignment between Holtwood and Christiana, and Water Street, Bridge Street, and Sadsbury Avenue through Christiana. At this time, the entire length of PA 372 was paved. PA 572 was designated to run from PA 372 in Christiana to PA 41 in Atglen on an unpaved road, following Bridge Street and Valley Avenue. At this time, the current alignment east of Atglen was unnumbered and was paved between Parkesburg and Coatesville. By 1930, a separate section of PA 572 was designated onto the paved road between PA 42 (now PA 10) in Parkesburg and PA 82 in Coatesville. In 1937, the road between Atglen and Parkesburg was paved and became a part of PA 572, resulting in a continuous route from PA 372 in Christiana to PA 82 in Coatesville.