Isner lost in the first round in Newport to eventual champion Rajeev Ram. He successfully defended his title in Atlanta in July to win his 10th ATP Tour title and third in a row at the tournament, defeating Marcos Baghdatis in the final in straight sets. The following week, he reached the final of the 500 tournament in Washington, D.C., losing in the final to Kei Nishikori. He also reached the quarterfinals of the Rogers Cup in Montréal, losing in three tiebreakers to Jérémy Chardy. However, the following week in Cincinnati, he bowed out in the first round against Sam Querrey. He then skipped Winston-Salem, his home tournament, the week before the US Open.