On 15 December, Perišić made his Coppa Italia debut in the round of 16 match against Cagliari at home, appearing as a second-half substitute and scoring the team's third goal of the match in an eventual 3–0 win. He began 2016 on 6 January in the match away against Empoli; his cross from close range was finished home by Icardi for the only goal of the match, which kept Inter top to the table. On 7 February, during the match against Hellas Verona, Perišić came on as a 46th-minute substitute to change the fate of the match, providing an assist for Icardi and also scoring for himself to level the result 3–3, rescuing a point for his side.