The roadway passes commercial establishments before coming to a bridge over Norfolk Southern's Reading Line, at which point it enters residential areas. PA 183 comes to an interchange with the PA 12 freeway (Warren Street Bypass), with local streets providing access to PA 12 af right-in/right-out ramps. Here, the roadway narrows to two lanes. A short distance later, the route enters Bern Township and becomes Bernville Road, passing through a golf course before heading past a mix of homes and businesses in Greenfield Manor. The road passes to the south of Reading Regional Airport, gaining a center left-turn lane before heading past industrial parks and Penn State Health St. Joseph hospital. PA 183 widens into a four-lane divided highway as it comes to an interchange with the US 222 freeway.