She and her third husband John Drew were the parents of Louisa Drew (1852–1888), John Drew, Jr. and Georgie Drew (Barrymore). She had no known children from her first two marriages. The Drews owned the Arch Street Theatre, where they staged performances, and she managed the business. The Arch Street was a competitor theatre of the still standing Walnut Street Theatre. After her husband's death Mrs Drew adopted a baby boy and named him Sidney. She was the grandmother through Georgie of John Barrymore, Ethel Barrymore and Lionel Barrymore. Her other grandchildren were Georgie Drew Mendum, Edward Mendum, ? Mendum, Louise Drew, and S. Rankin Drew. She is the great-great-grandmother of Drew Barrymore.