In 1809, the state authorized for a road between Parkesburg and McCall's Ferry on the Susquehanna River. PA 372 was first designated in 1928 to run between McCall's Ferry and PA 41 in Christiana. PA 572 was designated from PA 372 in Christiana to PA 41 in Atglen. Another section of PA 572 was designated between PA 42 (now PA 10) in Parkesburg and PA 82 in Coatesville by 1930; these two sections were linked in 1937. In the 1940s, PA 372 was rerouted to its current eastern terminus, replacing PA 572. PA 372 was realigned to its current western terminus in 1968 following the completion of the Norman Wood Bridge. The PA 272 intersection was relocated in 2007 in order to improve safety.