Zacharias was a frequent keynote lecturer within the evangelical community at events including the Future of Truth conference in 2004, the National Religious Broadcasters' Convention and Exposition in 2005, the National Conference on Christian Apologetics in 2006. On successive nights in October 2007, he addressed first the students and faculty of Virginia Tech, then the community of Blacksburg, Virginia, on the topic of evil and suffering in the wake of the Virginia Tech massacre. Zacharias has represented the evangelical community at occasions such as the National Day of Prayer in Washington, D.C., the Annual Prayer Breakfast at the United Nations, and the African Union Prayer Breakfast in Maputo, Mozambique, and was named honorary chairman of the 2008 National Day of Prayer task force. He also participated in the ecumenical Together 2016 meetings in July 2016, which Pope Francis addressed, describing the event as a valiant effort.