A Norfolk Southern Railway branch line between Sayre, PA and Ludlowville, NY runs through the western portion of the town, through the valley of the Cayuga Inlet. This railroad was built in 1871 as the Ithaca & Athens Railroad and later become part of the Lehigh Valley Railroad. There was a depot in West Danby, on the north side of Station Road, east of the tracks. Passenger service to West Danby ended in the 1940s and passenger service on this line ended in 1961.