An organocatalytic cascade was employed in the total synthesis of the natural product harziphilone, reported by Sorensen et al. in 2004 (Scheme 3). Herein, treatment of the enone starting material 13 with organocatalyst 14 yielded intermediate 15 via conjugate addition. Subsequent cyclization by the intramolecular Michael addition of the enolate into the triple bond of the system gave species 16, which afforded intermediate 17 after proton transfer and tautomerization. The cascade was completed by elimination of the organocatalyst and a spontaneous 6π-electrocyclic ring closure of the resultant "cis"-dienone 18 to (+)-harziphilone (19) in 70% overall yield.