US 111 continued north along what is now PA 297 (renamed from PA 295 in 2018). The U.S. highway followed the modern state highway except it continued straight where the state highway curves through its interchange with I-83 at Strinestown. US 111 followed modern PA 297 to just north of Conewago Creek, where PA 297 now turns east. The U.S. Highway followed Old Trail Road, which is a township road north to the village of Newberrytown. There, US 111 had an acute intersection with PA 24 (York Haven Road), which is today PA 382. The two highways ran concurrently through Newberrytown as Old Trail Road and split west of the village, with PA 24 continuing along PA 382's modern path on Lewisberry Road and US 111 following Old Trail Road, which is again a township road. Part of the U.S. Highway's course south of the village of Yocumtown was removed by construction of I-83, but resumes along part of PA 392 from Fishing Creek until PA 392 turns east onto Yocumtown Road. US 111 continued along a pair of township roads on either side of the boundary of Newberry Township and Fairview Township, where the highway's name changes to Old York Road. The township road ends at the modern intersection of PA 262 (Valley Road) and PA 177 (Wyndamere Road).