He was promoted in September 1966 to a Boston team that avoided the American League cellar by only game. Playing in five contests, all as a starter. He made his major league debut on September 18 against the California Angels at Fenway Park, going hitless in four at bats with a run scored. He got his first hit in the majors six days later at Yankee Stadium, a single off New York's Fritz Peterson. Andrews picked up two more hits in the season finale versus the Chicago White Sox at Comiskey Park.