As the Smurfs get ready for the Blue Moon Festival, Papa Smurf (voiced by Jonathan Winters) sees in his cauldron a vision of Clumsy Smurf (voiced by Anton Yelchin) reaching for a dragon wand and the Smurfs' longtime enemy, evil wizard Gargamel (Hank Azaria), capturing him. Not wanting this vision to come true, Papa disallows Clumsy to pick smurfroot, since the smurfroot fields lead to Gargamel's castle. Clumsy disobeys Papa and ends up unintentionally leading Gargamel and his pet cat Azrael (voiced by Frank Welker) to the village. The Smurfs all flee for their lives while Clumsy unknowingly runs towards the Forbidden Falls, with Papa, Smurfette, Grouchy, Brainy and Gutsy (voiced by Katy Perry, George Lopez, Fred Armisen and Alan Cumming respectively) running after him. They find him at the edge of a cliff, and while trying to help him up, they are sucked into a gigantic vortex that spirits them to 2011 New York City. To make matters worse, Gargamel and Azrael follow them through the vortex. The Smurfs end up in the apartment of Patrick and Grace Winslow (Neil Patrick Harris and Jayma Mays), a married couple who are expecting their first child, and their Basset Hound Elway. After introducing themselves and explaining their situation, the Winslows befriend them and allow them to stay in their apartment. The next day, needing to find a "stargazer", the Smurfs follow Patrick to his workplace at Anjelou Cosmetics, misunderstanding the previous explanation of his job as fortune-telling, where he calls Grace to pick them up.