This film is the third part of what Wood aficionados refer to as "The Kelton Trilogy", a trio of films featuring Paul Marco as "Officer Kelton", a whining, reluctant policeman. The other two films were "Bride of the Monster" and "Plan 9 from Outer Space". Although said to be a sequel to "Bride of the Monster", "Night of the Ghouls" featured only two characters from that film (Kelton and Lobo), and, in a retcon, it is claimed that Lt. Bradford had worked on the earlier case when he in fact did not appear in "Bride". His exploration of Dr. Acula's house was borrowed from Wood's short film "Final Curtain" and voice-over narration was added to integrate it into the story. As a result, there was no room for Harvey B. Dunn, who played Captain Tom Robbins in "Bride", to reprise his earlier role. Instead, he was given a small supporting role as a frightened motorist who encounters one of the "ghouls".