New York State Route 72 (NY 72) is a state highway in the North Country of New York in the United States. The road is an east–west highway located entirely within the eastern part of St. Lawrence County. The western terminus of NY 72 is at an intersection with NY 56 in the town of Potsdam, south of the village of Potsdam. Its eastern terminus is at a junction with NY 11B west of the community of Hopkinton in the town of Hopkinton.