In the 8th Century it was home to a Lombard garrison and supported the fortresses in Campione d'Italia, Arogno and Brusino Arsizio. Starting in the 9th Century, the monastery of S. Ambrogio in Milan owned property in Bissone. The parish church of St. Carpoforo, became partly independent in 1474 from the mother church at Riva San Vitale. It became fully independent in 1622, but retained a relationship with the monastery of San Pietro in Ciel d'Oro in Pavia. The Oratory of St. Rocco was built around 1630.