Isner broke into the top 100 at no. 93 in February with a quarterfinal appearance at an ATP event in San Jose, beating no. 90 Florent Serra and no. 26 Tommy Haas. He maintained a top-100 ranking in the first three months of the year, beating six players in the top 100, while playing exclusively in events at ATP level. Isner played at his first French Open and Wimbledon, losing in the first round of each. He also played at the US Open, where he lost in the first round. He ended the year ranked no. 144 in the world.