The Blob's mutant physiology grants him a number of advantages. He had superhuman strength, endurance, and great resistance to physical injury. The Blob's elastic, blubbery skin is difficult to penetrate by gunfire, missiles, and even Wolverine's claws, though with sufficient force and a favorable angle, the claws can lacerate his flesh. On one occasion, a concentrated optic blast fired by Cyclops was sufficient to puncture a hole through his shoulder, much to the shock of Dukes himself. The magic swords of both Black Raazer and the Arabian Knight were able to harm him.