Reyna married Danielle Egan, then a member of the United States women's national soccer team, in July 1997, one week after attending the FIFA All-Star Game in Hong Kong and two weeks after the U.S. team's World Cup qualifier at El Salvador. They have had four children: Jack (1999–2012), Giovanni (born 2002), Joah-Mikel, and Carolina. Giovanni, named after former Rangers teammate Giovanni van Bronckhorst, has achieved great success playing in the New York City FC development academy, and joined Borussia Dortmund's academy in November 2018. Jack, Reyna's eldest child, died of brain cancer in 2012. The family resides in Bedford, New York.