A short distance later, US 222 comes to a northbound exit and southbound entrance with the southern terminus of US 222 Bus., a business route that passes through the city of Reading, which US 222 bypasses to the west. From here, the route curves to the north and crosses back into Spring Township, passing near suburban residential development and coming to a partial cloverleaf interchange with PA 724 in a business area. The freeway turns to the northeast and passes through residential areas and some woodland between the community of West Wyomissing to the north and Lincoln Park to the south. US 222 briefly forms the border between Spring Township to the north and the borough of Wyomissing to the south before it bends to the north-northeast into Spring Township. The route crosses into Wyomissing and comes to an interchange with US 422 and the western terminus of US 422 Bus., at which point it also passes over Norfolk Southern's Harrisburg Line. At this interchange, US 422 becomes concurrent with US 222, and the two routes continue east-northeast along the six-lane Warren Street Bypass freeway, running between residential areas to the northwest and the Norfolk Southern tracks to the southeast. The freeway curves north into business areas and comes to a partial cloverleaf interchange with State Hill Road. Following this, US 222/US 422 passes between the Berkshire Mall to the west and commercial areas to the east before it reaches an interchange with Paper Mill Road and Crossing Drive, where it curves to the northeast and runs near more businesses. The freeway comes to an interchange where US 222 splits to the northwest, US 422 immediately afterward splits southeast along the West Shore Bypass, and, straight ahead, PA 12 begins northeast along the Warren Street Bypass.