On March 4, 2010, it was reported that the Chargers would tender Sproles a contract, which was worth approximately $7.3 million. Another team would have had to give the Chargers first- and third-round draft picks if they signed Sproles. He appeared in all 16 games and recorded 59 receptions for 520 yards and two touchdowns to go along with 50 carries for 267 rushing yards. On special teams, he had 51 kick returns for 1,257 net yards and 24 punt returns for 166 net yards.