Hossain defended Maulana Bhashani in a "habeas corpus" case. He was a lawyer for the English Rally brothers, who owned businesses in the Port of Narayanganj, and worked on a case for Chandranath Films. In 1963, Hossain began independent practice as a barrister. He represented "The Daily Ittefaq", one of East Pakistan's largest Bengali-language newspapers, when it was banned by the Pakistani government. East Pakistan Chief Justice Badruddin Ahmed Siddiky told Hossain's lead counsel Mahmud Ali Kasuri to give the floor to Hossain during the "Ittefaq" case, and Kasuri obliged. The verdict favored Hossain and Kasuri.