Holland has criticised Richard Ellmann's 1987 biography, "Oscar Wilde", as inaccurate, particularly his claim that Wilde had syphilis and transmitted it to Constance. According to "The Guardian", Holland has "unearthed medical evidence within private family letters, which has enabled a doctor to determine the likely cause of Constance's death. The letters reveal symptoms nowadays associated with multiple sclerosis but apparently wrongly diagnosed by her two doctors. One, an unnamed German 'nerve doctor', resorted to dubious remedies and the other, Luigi Maria Bossi, conducted a botched operation that days later claimed her life."