Caroline Hampton became the chief nurse of the operating room when Johns Hopkins Hospital opened in 1889. When "n the winter of 1889 or 1890" she developed a skin reaction to mercuric chloride that was used for asepsis, William Halsted, soon-to-be her husband, asked the Goodyear Rubber Company to produce thin rubber gloves for her protection. In 1894 Halsted implemented the use of sterilized medical gloves at Johns Hopkins. However, the first modern disposable glove was invented by Ansell Rubber Co. Pty. Ltd. in 1965.