In recent years, together with TV personality Fabio Fazio on his TV show "Che tempo che fa", she has entertained Italian audiences on prime time with her humorous remarks about social trends. She has also shed a light onto cultural, social and political topics, notably calling for a bill in Italy to protect women against sexual harassment. These appearances have established her as a prominent TV personality of contemporary Italy. Littizzetto teamed up with Fazio several times. More recently, they voiced two characters for the Italian version of the movie "Minions" in 2015.