In Super Bowl XLIII, Holmes secured the Steelers' NFL-record 6th Super Bowl win after catching a 6-yard touchdown pass from Ben Roethlisberger with 35 seconds left in regulation. Holmes caught nine passes for 131 yards and a touchdown, including four receptions for 73 yards on their final game-winning drive. He was named Super Bowl MVP, becoming the sixth wide receiver to win the award, and also was the third Pittsburgh receiver to win the award, following Lynn Swann in Super Bowl X and Hines Ward in Super Bowl XL.