During the "Origin of the Species" storyline, the Chameleon is invited by Doctor Octopus to join his supervillain team where he gets involved in securing some specific items for Doctor Octopus. He poses as Harry Osborn to trick Spider-Man by telling him that Menace's infant has died. When Spider-Man has been away, the Chameleon got the infant. Doctor Octopus later talks with the Chameleon saying that the baby is the first of a new species. Using a lead gained when he took down Shocker, Spider-Man arrives at the Kravinoff Mansion where he captures the Chameleon who reveals that the baby is still alive and is in the Lizard's clutches.