Ikpeba again teamed up with Sunday Oliseh at Borussia Dortmund in 1999, for a transfer fee of £4.8m. Ikpeba scored only two goals in his first season in the Bundesliga and barely played in his second, after falling out with the coach Matthias Sammer. Looking for a move abroad, Ikpeba turned down Southampton to join Real Betis on a season-long loan. Things went further downhill for the player in Spain as he was criticised for being overweight by the coach, after making just one appearance for the club. He didn't feature for Betis again up until the last two games of the season.