On May 25, 2007, Myers went on the disabled list for the first time in his career with a strained right shoulder. However, he returned in July to finish the year with 21 saves, remaining as the Philadelphia closer for the rest of the season. As the Opening Day starter and then the closer, Myers threw the first and last pitches of the 2007 season, and was on the mound as the Phillies clinched their first playoff spot in 14 years. He proved to be a successful reliever, going 5–5 with a 2.87 ERA in 48 relief appearances.