The following spring, the Lagimodières travelled to the valley of the Saskatchewan River, settling eventually in what is now northern Saskatchewan, where they remained until 1811, living a semi-nomadic lifestyle among other French-Canadian trappers and their native wives. During this period, Marie-Anne accompanied her husband on many trapping and buffalo hunting expeditions, often venturing as far west as present-day Alberta. Her second child was born on the open prairie shortly after her horse had bolted towards a herd of buffalo, and on another occasion she fought and shot a large bear that had attacked one of their companions.