On March 9, 2015, Ginn re-signed with the Carolina Panthers on a two-year contract. During a Week 4 victory against NFC South opponent Tampa Bay Buccaneers, Ginn had a career-high two touchdowns. Through the first four games of the season, Ginn had 12 receptions for 209 yards and three touchdowns, exceeding his total numbers for yards and touchdowns from the year before. Through the first 12 games of the season Ginn had 35 receptions for 525 yards and six touchdowns, including 15.0 yards per receptions. The six touchdown receptions during the season tied his totals from his time with Miami, San Francisco, and Arizona. Ginn finished the season with 44 catches for 739 yards and a career-high 10 touchdowns. Ginn's efforts as a receiver and return specialist helped the Panthers reach Super Bowl 50, where Ginn had four catches for 74 yards and three punt returns. However, the Panthers fell to the Denver Broncos by a score of 24–10.