Fungicides can be applied to the foliar from the R1-R4 stage of soybeans (late flowering to pod-filling stages). This kind of application can reduce the incidence and severity of the disease. Yield and seed quality can also be improved. In the United States, Frogeye leaf spot has been reported to have resistance to Quinone outside inhibitors (strobilurins). Using multiple active ingredients for a fungicide application can help prevent resistance. Seed treatments are a preventative method that can reduce the threat frogeye leaf spot.