Although accounts vary as to the phrase's origin, Quest is perhaps most remembered for reportedly coining the phrase "Charley horse" to describe a sudden leg cramp or sprain. Quest appeared in 596 major league games and compiled a .217 batting average with 499 hits and 161 runs batted in. In 1878, he led the National League in errors at all positions, though he also led the league's second basemen in fielding percentage in both 1879 and 1881. He also led all position players with 331 assists in 1879.