US 123 and US 76 head east on Windsor Street, meet the western end of SC 183 (Westminster Highway), and temporarily expand to a four-lane divided highway as they pass under the rail line. The U.S. Highways reduce to two lanes to pass through downtown Westminster, which includes the historic Southern Railway Passenger Station. At the east end of downtown, US 123 and US 76 veer onto Main Street, which becomes a four-lane road with center turn lane. The highways meet the northern end of SC 24 (West Oak Highway) in the eastern part of town. The U.S. Highways' name changes to Sandifer Boulevard as they leave Westminster and expand to a four-lane divided highway. The highways have a partial cloverleaf interchange with SC 11 (Cherokee Foothills Scenic Highway) and cross to the north side of the railroad, then become a four-lane road with center turn lane as they enter the town of Seneca. US 123 and US 76 intersect SC 28 (Blue Ridge Boulevard) and SC 59 (1st North Street), which head north and south, respectively, from the intersection. US 123, US 76, and SC 28 head east concurrently along the north side of Seneca south of Lake Keowee. The highways have a partial cloverleaf interchange with Pine Street before intersecting SC 130, which heads southwest along 1st North Street and northeast along Rochester Highway.