The road becomes East Sycamore Road and turns to the west-northwest, running to the north of the interstate through forests. The route bends west and passes homes before running near businesses and coming to an intersection with Beechcreek Road, which heads south to an interchange with I-80. From here, PA 144 passes commercial development before crossing into the borough of Snow Shoe, where it becomes East Sycamore Street and heads through residential areas. The road curves northwest and becomes West Sycamore Street before it heads back into Snow Shoe Township. The route runs west through wooded areas with some fields and development as West Sycamore Road, passing through the community of Gillintown. In the community of Moshannon, PA 144 intersects the northern terminus of PA 53 and turns north onto Spruce Road, passing through woodland with some fields and residences. The road comes to a junction with the eastern terminus of PA 879 and turns northeast into dense forests. The route enters Burnside Township and becomes an unnamed road, curving to the north. PA 144 enters the Sproul State Forest and turns northeast, becoming Ridge Road. Farther along, the road curves back to the north.