During Super Bowl XLIII, Harrison intercepted a pass from Cardinals quarterback Kurt Warner at the goal line and ran back the length of the field for a 100-yard touchdown at the end of the first half. In a memorable scene, Harrison collapsed in the endzone and spent several minutes regaining his breath as his teammates celebrated. It was the longest play in Super Bowl history (surpassing Desmond Howard's 99-yard kickoff return in Super Bowl XXXI, being broken by Jacoby Jones in 2013 with a 108-yard kickoff return) and helped the Steelers defeat the Arizona Cardinals 27–23. It was also the longest interception return in Steelers franchise history, surpassing the 99-yard return by Martin "Butch" Kottler which occurred in the club's and was the oldest team record on the books.