After crossing into the city of Rome, NY 46 and NY 49 enter the hamlet of Seifert Corners and begin winding eastward along Rome–New London Road along Wood Creek. The routes soon cross into the city of Rome's inner district, where they reach a junction with NY 69 (Erie Boulevard West). NY 69 joins the concurrency with NY 46 and NY 49, running southeast along Erie Boulevard West through a large commercial strip in Rome. After the fork with West Dominick Street, the routes bend into the residential section of Rome, running along the southern extremities of the city, passing the Civic Center and soon entering a large interchange with NY 26. At this junction, NY 69 continues south along NY 26 south while NY 46 turns north along NY 26 north on Black River Boulevard North.