She graduated from high school in 1918, and began working as a stenographer at a local law office. There she met Bernard Nevelson, co-owner with his brother Charles of the Nevelson Brothers Company, a shipping business. Bernard introduced her to his brother, and Charles and Louise Nevelson were married in June 1920 in a Jewish wedding at the Copley Plaza Hotel in Boston. Having satisfied her parent's hope that she would marry into a wealthy family, she and her new husband moved to New York City, where she began to study painting, drawing, singing, acting and dancing. She also became pregnant, and in 1922 she gave birth to her son Myron (later called Mike), who grew up to be a sculptor. Nevelson studied art, despite the disapproval of her parents-in-law. She commented: "My husband's family was terribly refined. Within that circle you could know Beethoven, but God forbid if you were Beethoven."