Needless to say, at the end of the 16th century there were very few Spaniards that lived in the vicinity of Tlaltenango. In the decade of 1540, probably after the Mixtón War, the towns of the valley were entrusted as encomiendas to a number of Spaniards. The town of Tlaltenango was entrusted to Toribio de Bolaños, Tepechitlán to Pedro de Bobadilla, a soldier of Nuño Beltrán de Guzmán, and El Teúl was an encomineda of Juan Delgado. It is unlikely that these individuals were able to exercise their rights over the indigenous populations during the 16th century, given that the successive rebellions would have made it difficult. However, with the end of war, Spaniards began arriving and settling among the newly pacified indigenous inhabitants of the region.