At the US Open, Rodionova defeated Bojana Jovanovski in the first round, and fell to fellow Australian Sam Stosur in the second. In doubles, she continued her partnership with Cara Black as ninth seeds. The pair defeated alternative pair Alberta Brianti and Urszula Radwańska in the first round. In the second round, they defeated Alla Kudryavtseva and Darya Kustova. They defeated their German opponents Julia Görges and Anna-Lena Grönefeld to advance to the quarterfinals, where they beat the 14th seeds Elena Vesnina and Vera Zvonareva in three sets. Black and Rodionova were finally defeated by sixth seeds Vania King and Yaroslava Shvedova in the semifinals. Advancing into the semifinals of a Grand Slam tournament for the first time, Rodionova has reached her career-high doubles ranking of world No. 28.