In his first appearance, an elderly Silvermane forced Dr. Curt Connors to make a potion from an ancient clay tablet in order to grant himself immortality. He first crossed paths with Conners's alter-ego, the Lizard, and Spider-Man during this scheme. Drinking the serum made Silvermane younger, but its effects caused him to de-age further and further until he was a infant before completely disappearing. Silvermane eventually reappeared, revealing that he had mystically aged to his forties. He started a new career and again quickly rose through the Maggia's ranks until he regained control of his family, the sought to form an alliance with Hydra, determined to take over the world as their leader, the Supreme Hydra. He was defeated by Daredevil, Nick Fury and S.H.I.E.L.D. Silvermane reappeared in New York in an attempt to unite all of New York's gangs under his leadership and take over the criminal underworld, but his plans were complicated by the Green Goblin, who opposed him. During a confrontation between the Goblin, Silvermane and Spider-Man, Silvermane fell from a great height but survived.