During his recovery, Little began developing exercise programs and became successful in the fitness industry. His book "One on One with Tony Little: The Complete 28-Day Body Sculpting And Weight Loss Program" has sold thousands of copies. His fitness videos have won 14 Platinum Awards, 9 gold video awards, and over 47 million customers. His products are sold by retailers worldwide, including HSN and QVC. His most notable product is the Gazelle which was co-created by Little, colleague Harper Williams, and Fitness Quest.