Codeine is probably Robiquet's most important contribution, that prevails still today with a very strong presence and impact on daily life; in effect, until the beginning of the 19th century, raw opium was used in diverse preparations known as laudanum (see Thomas de Quincey's "Confessions of an English Opium-Eater"), paregoric elixirs (a number of them, very popular in England since the beginning of the 18th century), and health or even death hazards to users from improper preparation or improper use were frequent.