Due to the game's success several sequels have been made: "Destroy All Humans! 2", which takes place in the 1960s and marks the first time Crypto invades across the globe, "Destroy All Humans! Big Willy Unleashed", a spin-off set in the 1970s in which Pox and Crypto run a fast-food chain, and "Destroy All Humans! Path of the Furon", which also takes place in the 1970s and begins with Crypto and Pox running a lucrative gambling casino called the "Space Dust".