Entering the 2006 season, Ginn was considered by many to be a preseason candidate for the Heisman Trophy and the Biletnikoff Award. He was a second team All-American selection and finished as the Buckeyes top receiver with 59 catches for 781 yards, while adding another 706 yards and two touchdowns on special teams. Ginn returned the opening kickoff of the 2007 BCS National Championship Game for 92 yards and a touchdown. Ginn sprained his left foot when fellow Buckeye Roy Hall slid into him during the celebration following the touchdown and sat on his foot. He left the game soon after and didn't return.