The town is within the former realm of the Oneida and Tuscarora people. A tract of land in the town was purchased by Benjamin Hovey, from Oxford, Massachusetts. The first settlers in Oxford arrived in the spring of 1789. Elijah Blackman, his son Jabez Blackman, and eleven-year-old adopted daughter Polly Knapp built a primitive log cabin on an island in the Chenango River. The little island on which the Blackman family had squatted had previously been bought by Benjamin Hovey, who when he came on later to take possession, gave them in consideration of the improvements made, a piece of land, a mile and a half up the river. Blackman resided there until his death, which occurred about the year 1825.