The road leaves Parkesburg for Sadsbury Township and heads through a mix of farmland and woodland with some homes on Valley Road, crossing Buck Run. The route turns north at the Strasburg Road intersection and turns east a short distance later, passing through the residential community of Pomeroy. PA 372 enters Valley Township and runs through wooded areas with some fields and residential neighborhoods, heading through the community of Westwood and crossing under an abandoned railroad line. The road passes between homes to the north and an ArcelorMittal (formerly Lukens Steel Company) steel plant to the south, becoming the border between the city of Coatesville to the north and Valley Township to the south before fully entering Coatesville. PA 372 reaches its eastern terminus at an intersection with PA 82.