PA 150 begins at an intersection with PA 26/PA 144 Truck in College Township, Centre County, heading northeast on Benner Pike, a five-lane road with a center left-turn lane. The route runs through shopping areas, passing to the west of Nittany Mall. Past the Shiloh Road intersection, the road becomes a three-lane road with a center left-turn lane, heading into farmland with some development and crossing into Benner Township. At this point, PA 150 runs through agricultural areas on the grounds of State Correctional Institution – Rockview and becomes a two-lane road. The route heads north and reaches an interchange with I-99/US 220 before leaving the state prison grounds and gaining a center left-turn lane again, heading past farmland before running near commercial establishments. The road curves to the north-northwest as it runs through a mix of farmland and woodland with some businesses, becoming a two-lane road again. PA 150 crosses into Spring Township and turns northeast, heading into residential areas, becoming Willowbank Street.