Past the US 222 interchange, the route narrows back into a two-lane undivided road and passes businesses and homes in the community of Leinbachs. Farther northwest, the roadway heads into a mix of farmland and woodland with development. PA 183 heads west and crosses into Penn Township, continuing through more rural areas with some homes. The route passes through Pleasant Valley and heads to the north of Blue Marsh Lake along the Tulpehocken Creek, curving to the northwest. The road continues through wooded areas and fields with some residences as it continues along the northeastern side of the lake. Past Blue Marsh Lake, PA 183 enters the borough of Bernville and passes to the west of residential and commercial development in the town. The road leaves Bernville, at which point it briefly passes through Jefferson Township and Penn Township again before crossing Northkill Creek back into Jefferson Township. The route passes through agricultural areas with some trees and development, curving to the north.