In 1554 the physician Andres Laguna published his Annotations on Dioscorides of Anazarbus printed by Guillaume Rouillé in Lyons. Laguna was the first to translate De Materia Medica into Castilian. His translation was made from one of the Latin editions of Jean Ruel. It was also based on classes Laguna took from Ruel as his pupil in Paris. Laguna points out some of his teacher's erroneous translations, and adds many commentaries, which make up more than half of the total work.