Shortly after entering Brighton, I-390 crosses over the Erie Canal and meets the southern terminus of I-590 at a large semi-directional T interchange located adjacent to the canal and South Clinton Avenue. The latter of the two passes through the eastern half of the junction, crossing over I-590 but passing under the ramps connecting I-590 south to I-390 south and I-390 north to I-590 north. Past the exit, I-390 turns to the west, joining the Rochester Outer Loop and crossing back over the canal ahead of an interchange with NY 15 and NY 15A. After passing under NY 15, the freeway begins to run along the southern edge of the Erie Canal, here delimiting the southern city limits of Rochester. The canal and I-390 run side-by-side for just over to the Genesee River, where I-390 veers slightly to the west as it meets NY 383 at a partial cloverleaf interchange.