Thame railway station was opened in 1862 as the temporary terminus of an extension of the Wycombe Railway from . The extension was completed in 1864 when it reached . In 1963 British Railways withdrew passenger services between and Oxford and closed Thame station, leaving Princes Risborough (7 miles) as the nearest passenger station until 1987 (see below) BR dismantled the track between Thame and , but kept the line between Thame and Princes Risborough open for goods traffic to and from an oil depot in Thame.