Ozuna signed with the Chicago White Sox on January 19, . He appeared in a career high 70 games and also had career highs with 203 at bats, 56 hits, and 11 RBI. Ozuna also had 14 stolen bases including a steal of home. He was brought back in and on May 3, 2006, he hit his first career home run, a solo shot, to tie the game with two outs in the 9th inning against Eddie Guardado of the Seattle Mariners.