Following this, she competed at the Family Circle Cup, a Premier-event on the WTA Tour. As a direct entrant in the main draw, she defeated Melinda Czink in the first round before stunning world No. 27, Anabel Medina Garrigues, in straight sets, in the second round. She was beaten by 2004 champion Venus Williams in the third round. Despite the loss, this was Rodionova's best performance of the year. In the e-Boks Open in Copenhagen. She lost to Kaia Kanepi. She then traveled to Morocco to participate in the WTA's lone African event, the Fes Grand Prix. She suffered another defeat, to Chanelle Scheepers. She then lost in the qualifying rounds in Estoril. She continued her clay-court season, competing at the Madrid Open, where she qualified for the main draw, but lost in the first round to Czech Andrea Hlaváčková. This saw her ranking drop 14 spots to world No. 106. In Rome, she again qualified for the main draw before losing a disappointing match to in-form German Angelique Kerber. Rodionova then lost in the qualifying draw of the Brussels Open and in the first round of the main draw of the French Open.