In 2004, Menounos appeared in an episode of the UPN series "One on One" as Glenda, an eccentric, self-proclaimed "Fairy Godmother to the Stars". In the summer of 2005, she appeared in the comic book film "Fantastic Four", where she played a nurse who is romanced by the Human Torch, played by Chris Evans. Her likeness and voice was featured in the 2005 Electronic Arts video game "James Bond 007: From Russia with Love" as Eva Adara, Red Grant's henchwoman, which stars Sean Connery as James Bond. She is also the spokesperson for Pantene hair products. Menounos presented the 2006 "Eurovision Song Contest" (along with Greek singer Sakis Rouvas) which took place in Athens. Menounos also directed "Longtime Listener" starring Wilmer Valderrama. The film was an official selection of the Tribeca Film Festival 2006. Menounos acted in and produced "Adventures of Serial Buddies", which is credited with being the first serial killer buddy comedy.