The route takes a rather meandering path through southeast Alabama. It heads in a northeast direction to pass through Phenix City near the Georgia state line, then cuts back to the west to pass through Opelika; the portion between Phenix City and Opelika is concurrent with U.S. Route 280. From Opelika, US 431 swings back and forth between northwest and northeast as it works its way through the southern extent of the Appalachian Mountains, then turning northwest to pass through Talladega National Forest, arriving at a junction with Interstate 20 a few miles east of Oxford. The combined routes travel westward from Exit 191 into Oxford, where US 431 splits off at Exit 188 and heads northward through Oxford and the adjacent city of Anniston; through this section the route is named Veterans Memorial Parkway.