The US 222 freeway enters Brecknock Township in Berks County and continues north, passing a northbound weigh station before coming to a partial cloverleaf interchange serving the northern terminus of PA 272 and the western terminus of PA 568. Past this interchange, the route crosses into Spring Township and runs through wooded areas with some fields and homes, curving to the northeast and reaching a diamond interchange at Mohns Hill Road to the west of the community of Gouglersville. Here, the freeway crosses into Cumru Township and runs north-northeast through more rural areas, coming to a diamond interchange that connects to Grings Hill Road west of the borough of Mohnton.