While platting Knoxville with his son-in-law, Charles McClung, in 1791, White ordered at least one lot to be set aside for a church and cemetery. The cemetery spot may have been used as early as the 1780s for burials, and the cemetery contained several graves by 1799, but the earliest marker is Blount's, dated 1800. While the First Presbyterian congregation was active in the 1790s, the first church was not built on the site until 1816. The graveyard was used for burials for nearly sixty years, its most active period being during the Epidemic of 1838, in which hundreds of Knoxvillians died from an unidentified illness.