The community started when the nearby town of Camden, Delaware would not grant access to the Delaware Railroad (later part of the Pennsylvania Railroad), which bypassed the town and built a railroad station one mile west of the center of town and named the area West Camden. In 1865, minister John J. Pierce moved to West Camden from the Wyoming Valley and laid out plots for new housing. Several individuals from the Wyoming Valley moved to the new community and it was decided to rename the community. The community, "Desiring to sever any shared identity or connection with Camden, residents chose to honor the new citizens by changing the name of the community to Wyoming." A post office was erected in 1866 and the community was incorporated into a town in 1869.