In 1999, she exhibited at the Cannes Film Festival, and met Virginie Despentes, who was seeking actresses to perform explicit unsimulated sex in her first film "Baise-moi" (Fuck Me, Virginie Despentes and Coralie Trinh Thi, 2000). In addition to Lancaume, Raffaëla Anderson, another French porn actress, was also chosen. The film is based on the novel by Virginie, which narrates the encounter between Nadine (Karen) and Manu (Raffaëla) and her subsequent flight, transformed into an vengeance against society and the male gender.