The route becomes a four-lane freeway called the Kutztown Bypass, which bypasses the borough of Kutztown to the northwest, with a northbound exit and southbound entrance at Kutztown Road providing access to Kutztown. The freeway heads northeast through agricultural areas and crosses into Maxatawny Township, where it comes to a southbound exit and northbound entrance at Crystal Cave Road that provides access to Crystal Cave and the community of Virginville. From here, the route heads through more rural land before it passes through a section of Kutztown and runs near residential areas and farmland north of the Kutztown University of Pennsylvania campus. US 222 crosses back into Maxatawny Township and curves east, passing over the Sacony Creek and coming to a partial cloverleaf interchange with the southern terminus of PA 737 that provides access to Kutztown. The freeway crosses back into Kutztown and passes near homes before it reenters Maxatawny Township and the Kutztown Bypass ends at a southbound exit and northbound entrance with Kutztown Road that serves the borough. From here, US 222 becomes two-lane undivided Kutztown Road and runs east-northeast through farmland before heading past businesses near the Long Lane intersection. The route gains a center left-turn lane and passes through the residential community of Monterey before it continues through agricultural areas. Farther east, the road heads into the community of Maxatawny, where it is lined with homes and a few businesses.