In the five years from 2004/05, the ICR developed on average two drug development candidates per year. Since 2006, it has licensed three novel series of anti-cancer drugs to major pharmaceutical companies: Hsp90 inhibitors to Novartis, PKB inhibitors to AstraZeneca and PI3Kinase inhibitors to Genentech. The PIl3Kinase inhibitor GDC-0941, licensed to Genentech by Piramed, is thought to have potential in a range of human cancers. In laboratory experiments, ICR scientists found that the drug reduced the growth of glioblastoma (the most common form of brain tumour), it decreased the growth of ovarian tumours and in other studies, it was active against cell lines derived from other human cancers.