The westernmost part of PA 212 between Quakertown and Richlandtown was part of the Richland Turnpike or Plank Road Company, a company established in 1854 to build a turnpike connecting present-day PA 313 and PA 412. PA 212 was first designated by 1927 to run from U.S. Route 309 (US 309, now PA 309) and PA 312 (now PA 663) in Quakertown northeast to US 611 (now PA 611) in Riegelsville. The easternmost part of PA 212 was completed by 1940. PA 313 was designated concurrent with PA 212 on Broad Street in Quakertown by the 1970s. By the 1990s, the west end of PA 212 was cut back to its current location, removing the concurrency with PA 313.