In Week 4 of the 2019 season against the Minnesota Vikings, Daniel replaced an injured Trubisky in the first quarter. He completed 22 of 30 passes for 195 yards and a touchdown to Tarik Cohen as the Bears won 16–6. With Trubisky unable to play the following week's game against the Oakland Raiders in London, Daniel started as quarterback. Although he threw for 231 yards and two touchdowns, he was also intercepted twice, once late in the game, as the Bears lost, 24–21.