On August 14, Wieters collected a career-high five hits after going 5-for-5, scoring two runs, and having a double and triple in an 8–7 Orioles comeback victory over the San Francisco Giants. He was the first Oriole catcher since 1991 to have a 5-hit game and only the third catcher in Orioles history to do so. On August 30, Wieters hit a game-winning two-run homer against the Toronto Blue Jays in the eighth inning, securing a 5–3 victory for the Orioles.