Entering the hamlet of Brick Tavern, NY 66 reaches a junction with NY 9H in the southern end of the hamlet. NY 66 continues northeast through the town of Claverack, reaching the southern terminus of CR 20 at the eastern end of Brick Tavern. Passing south of Columbia County Airport, the route passes the junction with former CR 20, crossing into the town of Ghent. Continuing northeast, NY 66 remains rural in nature, soon reaching a junction with CR 9 (Mellenville Road). NY 66 reaches the hamlet of Ghent, where it meets a junction with the southern terminus of a section of CR 21 (Church Street).