In 2000–2001, she was the director of the Office of Science at the U.S. Department of Energy. From 2003 to 2008, she was the chair of the governing board of the American Institute of Physics. She also has served as president of the American Physical Society, the first female president of the American Association for the Advancement of Science, and treasurer of the National Academy of Sciences. Dresselhaus devoted a great deal of time to supporting efforts to promote increased participation of women in physics. In 1971, Dresselhaus and a colleague organized the first Women's Forum at MIT as a seminar exploring the roles of women in science and engineering.