US 111 continued north from the state line along what is now SR 3001 (Susquehanna Trail) all the way to the city limits of York. The highway intersected the Stewartstown Branch of the Northern Central Railway and became Main Street through the borough of Shrewsbury, where the highway intersected PA 851 (Forrest Avenue). US 111 continued north and met the eastern end of PA 216 (Glen Rock Road) northeast of Glen Rock. The U.S. Highway continued through Loganville and Jacobus, following Main Street through both boroughs. US 111 crossed the East Branch of Codorus Creek, ascended to the village of Leader Heights, and entered the city of York next to the York Hospital just north of where I-83 Business now intersects Susquehanna Trail. The U.S. Highway continued along what is now I-83 Business (South George Street) into downtown York. At the central square, US 111 intersected Market Street, which carried US 30, PA 24, and PA 74.