He is not accredited with an official wife, but he supposedly fathered three sons and one daughter. His second son died with him at Sekigahara while his other two argued male offspring either fell with the Toyotomi family at Osaka Castle or lived past the wars in seclusion. Yoshitsugu's daughter, Chikurin-in was a wife of Sanada Yukimura and mother of his two heirs: Sanada Daisuke (Yukimasa) and Sanada Daihachi (Morinobu). A purposed folktale states Yoshitsugu had one concubine prior to Sekigahara, who went insane with grief after his death. While it is unknown if the claim holds any merit, Tsuda Sutezō of the Byakkotai was rumored to have been one of his descendants.