A member of the Arquette acting family, he first became known during the mid-1990s after starring in several Hollywood films asides from the "Scream" franchise, such as "Wild Bill", "Never Been Kissed", "Buffy the Vampire Slayer", "See Spot Run" and "Eight Legged Freaks". He has since had several television roles, such as Jason Ventress on ABC's "In Case of Emergency". Arquette has also voiced Skully on the Disney Channel animated series "Jake and the Never Land Pirates", and executive produced the game show Celebrity Name Game, for which he received a Daytime Emmy Award nomination.