The second phase of Safdie’s career coincided with the establishment of a branch office. In 1970, Safdie opened a Jerusalem office. Safdie's work during this period combined his interests in social activism and advanced technologies with profound respect for historic and regional context. He worked on the restoration of the Old City and the construction of Mamilla Center, linking Old and New Cities. Other significant works in Israel include New City of Modi’in, Yad Vashem Holocaust History Museum, Yitzhak Rabin Center for Israel Studies, Ben Gurion International Airport, National Campus for the Archeology of Israel, multiple projects for Hebrew Union College, and others. During this period, Safdie also worked with leaders in Senegal and Iran.