"In Your Eyes" was not released as a single in the UK but was pulled as the third single from "So" in the US, achieving strong radio airplay and regular MTV rotation. It reached No. 1 on the U.S. "Billboard" Mainstream Rock Tracks on 13 September 1986, and peaked at No. 26 on the "Billboard" Hot 100 in November. Gabriel released two extended versions of the song as a 12" vinyl single in the US. The first (the Single Mix) ran 6:15. The second (the Special Mix) ran 7:14. In Australia, "In Your Eyes" peaked at No. 97 in November 1986.