Today, it is also one of the Amazon Basin's most active waterways, and helps export close to four million tons of grains, which are loaded onto barges in Porto Velho, where both Cargill and Amaggi have loading facilities, and then shipped down the Madeira to the ports of Itacoatiara, near the mouth of the Madeira, just upstream on the left bank of the Amazon, or further down the Amazon, to the port of Santarem, at the mouth of the Tapajos River. From these two ports, Panamax-type ships then export the grains - mainly soy and corn - to Europe and Asia. The Madeira waterway is also used to take fuel from the REMAN refinery (Petrobras) in Manaus, state capital of Amazonas, to Porto Velho, from where the states of Acre, Rondonia and parts of Mato Grosso are supplied mainly with gasoline (petrol) refined in Manaus. Cargo barges also use the Madeira on the route between Manaus and Porto Velho, which is along the Rio Negro, Amazon and Madeira, connecting Manaus' industrial district with the rest of Brazil, as Manaus is land-locked as far as logistics with the rest of the country are concerned, to bring in part of its raw materials, and export its produce to the major consumer centres of São Paulo and Rio de Janeiro. In 2012, the cargo amounted to 287,835 tons (both directions). The total tonnage shipped in 2012 on the Madeira accounted to 5,076,014.