After teaching at Hunter College from 1908 to 1910, and in the New York City high school system (1910-1912, 1914-1915), she became a Research Fellow at Bryn Mawr College from 1915 to 1917; she then went on to teach at Wells College from 1917 to 1918 as Instructor of Physics (also acting as head of the physics department), and at the Connecticut College for Women (1918 to 1920). She joined the mathematics department at Long Island University (LIU) in Brooklyn, New York (LIU Brooklyn) in 1934, became department chair in 1945 (taking over from Hugh when he became Professor, and Chair, of Art at LIU ), and was made a full professor in 1947, until her retirement in 1954; she was appointed director of LIU's Galois Institute of Mathematics (later the Galois Institute of Mathematics and Art) (named for Évariste Galois) in 1934. Over her career she published some 17 books, which were written in a unique, free-verse style and illustrated with whimsical line drawings by her husband. Her highly accessible writings were praised by no less than Albert Einstein, Cassius Jackson Keyser, Eric Temple Bell, and S. I. Hayakawa. Concerning her book, "The Education of T. C. MITS", Dorothy Canfield Fisher said: