Daphne's most significant developing relationship over the course of the series is with Frasier Crane's younger brother, Niles. Unbeknownst to Daphne, Niles falls in love with her in the third episode, when they first meet. Despite how Niles shows more and more signs of being infatuated with her, she remains completely oblivious to this, though they become increasingly close friends. Niles says nothing to Daphne, at first because he is married, later because she is involved with numerous (frequently unsuccessful) relationships with other men. Even when she is not, Frasier has one excuse or another to prevent Niles from telling her anything.