The parkway begins at an at-grade intersection with Route 109 in Lower Township, Cape May County, where Route 109 continues south towards the city of Cape May and west towards the Cape May–Lewes Ferry. The GSP runs north as a four-lane controlled-access highway on the Cape May peninsula through the Cape Island Wildlife Management Area, running west of swampland, separating the highway from the Jersey Shore communities. Trees occupy the median and the sides of the road for the next several miles. After passing to the east of Cape May National Golf Club, crossing over Jones Creek, and passing a pond in the median, the highway enters Middle Township and has an interchange with Route 47, which serves The Wildwoods resort area and the community of Rio Grande. North of this point, the parkway crosses over the abandoned Wildwood Branch of the Pennsylvania-Reading Seashore Lines (PRSL), and afterwards, the trees in the median disappear and the highway has a partial interchange with Route 147, which provides access to North Wildwood, Whitesboro, and Burleigh. Crossing into the county seat of Cape May Court House, the median narrows and US 9 appears within yards of the southbound lanes of the parkway as it passes west of the Wildwood Golf and Country Club. The two highways then split apart and the GSP bisects residential areas before reaching an interchange for County Route 657 (CR 657), which serves the Cape Regional Medical Center and the borough of Stone Harbor.