After the no-hitter, Liriano made several strong appearances, including an exceptional start on June 12 against the Texas Rangers. He retired the first 19 batters in order and didn't give up a hit until the 8th inning. Liriano's performance faded later in 2011. After an exceptional outing against the New York Yankees, he left his next start on August 25 after just two innings. He made his way to the disabled list with shoulder strain and did not start another game for the rest of the year. He finished the season with a record of 9–10 and an ERA of 5.09.