In the small midwestern town of Kings Row, in 1890, five children know and play with each other: Parris Mitchell, a polite, clever little boy who lives with his grandmother; pretty blonde Cassandra Tower, daughter of the secretive Dr. Alexander Tower and a mother that is seen only through the upstairs window; the orphaned but wealthy and fun-loving Drake McHugh who is best friends with Parris; Louise Gordon, daughter of the town physician Dr. Henry Gordon; and the tomboy Randy Monaghan, from the "wrong side of the tracks", whose father, Tom, is a railroad worker.