On November 11, 2007, in the Chargers' 23-21 upset over the Indianapolis Colts, Sproles made history by returning a kickoff and a punt for his first two NFL touchdowns—the first player in league history ever to do so. He returned the opening kickoff 89 yards for the game's first score. After Nate Kaeding's field goal increased the Chargers' lead to 10-0, Sproles returned a Hunter Smith punt 46 yards for another touchdown for a 16-0 lead. Sproles became the first player to return a kickoff and a punt for a touchdown in the same game since Dante Hall did so in 2003.