Senderos eventually fell out of favour with Arsenal manager Arsène Wenger. On 27 August 2008, he joined Italian club Milan on a season-long loan. Senderos described joining Milan as a "dream come true". He quickly incurred an injury and struggled to make the first team ahead of centre-backs Paolo Maldini and Kakha Kaladze, but finally made his first full appearance for the "Rossoneri" in a UEFA Cup group stage match against Braga, and came on as a substitute for his first Serie A appearance, against Fiorentina, approximately halfway through the season. Despite wanting his move at Milan to be permanent, Senderos returned to Arsenal after 14 Serie A appearances.