Sproles was given his largest workload since the 2009 season in a Week 13 game against the 10-1 New England Patriots, due to the ineffectiveness of Murray and Mathews being hurt. Sproles had 15 carries for 66 yards, 4 catches for 34 yards, and 5 punt returns for 115 yards and a touchdown in the 35-28 upset win. Sproles followed it up with a solid game against the Bills, with 7 carries for 41 yards and a touchdown in the 23-20 win.