Past this interchange, US 222 heads northwest as a four-lane freeway, crossing back into Spring Township and running between a farm field to the southwest and the Penn State Berks university campus to the northeast before reaching a diamond interchange with Broadcasting Road. The route runs between a shopping center to the southwest and Tulpehocken Valley County Park to the northeast prior to reaching the Spring Ridge Drive exit. At this point, the freeway turns north and crosses the Tulpehocken Creek into Bern Township and runs north-northeast through wooded areas with some nearby homes and commercial development, coming to a partial cloverleaf interchange with PA 183. Following this, US 222 curves northeast, passing to the northwest of Reading Regional Airport and running through farm fields before crossing the Schuylkill River into Muhlenberg Township. The route passes near residential neighborhoods and some commercial development, passing over the Reading Blue Mountain and Northern Railroad's Reading Division line and reaching a partial cloverleaf interchange with PA 61. The freeway passes under another Reading Blue Mountain and Northern Railroad line and Norfolk Southern's Evansville Industrial Track, crossing into Ontelaunee Township. At this point, US 222 heads northeast through industrial areas, with Norfolk Southern's Reading Line parallel to the southeast. The freeway comes to an end at a trumpet interchange, where US 222 intersects the northern terminus of US 222 Bus. and merges onto that road.