Based on data from the 2010 United States Census, the population of Great Kills was 40,720, a change of -960 (-2.4%) from the 41,680 counted in 2000. Covering an area of , the neighborhood had a population density of . The racial makeup of the neighborhood was 87.5% (35,649) White, 0.4% (169) African American, 0.1% (26) Native American, 3.0% (1,233) Asian, 0.0% (8) Pacific Islander, 0.1% (56) from other races, and 0.8% (331) from two or more races. Hispanic or Latino of any race were 8.0% (3,248) of the population.