PA 372 splits from PA 896 by heading east on Christiana Pike, at which point PA 896 turns west towards the community of Georgetown. PA 372 continues east through farmland and crosses into Sadsbury Township, where it passes through the community of Smyrna. The road heads into wooded areas with some homes as it enters the borough of Christiana. Here, the route bypasses the center of Christiana to the south along borough-maintained Germantown Avenue. PA 372 turns southeast onto state-maintained South Bridge Street and runs through woodland with some development on the west bank of the East Branch Octoraro Creek.