Beginning in the 1930s, Pesotta became a member of the ILGWU staff and regularly traveled to organize workers outside of New York. For example, in 1933, the ILGWU sent her to Los Angeles to organize garment workers. She organized the primarily Mexican immigrant garment workers, which led to the Los Angeles Garment Workers Strike of 1933. Strikes were a rarity in this notoriously "open shop" city, and so her success in Los Angeles led to her appointment as vice-president of the union in 1934 (only the third woman to be so chosen, following Fannia Cohn). In Montreal in 1937, her efforts included work to transform the nascent movement from one focused on Jewish seamstresses to one that was also inclusive of French-speaking women. As a result, Catholic media suggested she be deported. She also worked in organizing efforts in Puerto Rico (1934), Akron, Milwaukee, and elsewhere.