In the context of our example, Joe's blood pressure should not depend on whether or not Mary receives the drug. But what if it does? Suppose that Joe and Mary live in the same house and Mary always cooks. The drug causes Mary to crave salty foods, so if she takes the drug she will cook with more salt than she would have otherwise. A high salt diet increases Joe's blood pressure. Therefore, his outcome will depend on both which treatment he received and which treatment Mary receives.