Golam Mowlah is the founder vice-chancellor of Comilla University who served until he was removed on 30 July 2008. Zulfikar Ali, a professor of mathematics, was given the charge as acting vice-chancellor. The next vice-chancellor of Comilla University, A.K.M. Zehadul Karim declared his resignation on 7 October 2009 after major violence in campus. Amir Hossen Khan, a professor of Physics department of Jahangirnagar University, was appointed as Vice-Chancellor on 22 November 2009. After expiration of the duration of Amir Hossen Khan then Dr. Ali Ashraf, a professor of Economics department and Ex-President of Chittagong University Teachers Association has been appointed as the 5th Vice-Chancellor of Comilla University. He joined the university on 3 December 201. Professor Dr. Emran Kabir Chowdhury on Wednesday,Jan 31, 2018 joined as the 6th Vice Chancellor of Comilla University.