On January 1, 2012, in the last regular season game, a 45–17 blowout of the Carolina Panthers, Sproles had 168 all-purpose yards, in which he had 5 returns for 99 yards (2 kick-off returns for 45 yards and 3 punt returns for 54 yards) on special teams, and broke the NFL record for all-purpose yards in a season (2,696). Sproles played in both of the Saints' playoff games, scoring 3 touchdowns, including a 44-yard catch and run in the fourth quarter of a celebrated back-and-forth contest against the San Francisco 49ers that the Saints ultimately lost 36-32.