In Tokyo at the Toray Pan Pacific Open, Alona was defeated in the second round by third seed Jelena Janković. At the 2010 China Open – Women's Singles, Alona lost in the second round to thirteenth seed Nadia Petrova. Seeded third at the Generali Ladies Open, Alona suffered a first round loss at the hands of Roberta Vinci. Alona played her final tournament of the season at the Kremlin Cup. She was defeated in the second round by eighth seed María José Martínez Sánchez.