Continuing out of Ghent, NY 66 crosses over an abandoned railroad grade and a junction with another section of CR 9 (Arnolds Mill Road). At CR 9, NY 66 turns north through the town of Ghent, reaching the hamlet of Buckneyville. The two-lane roadway remains rural for this portion but the road crosses into the village of Chatham, where it gains the moniker of Hudson Avenue. Crossing through a residential section of Chatham, NY 66 reaches a junction in the eastern end of the village with NY 203 (Church Street / Coleman Street). Passing the Chatham Rural Cemetery, NY 66 enters the Depot Square, where it passes Chatham's New York Central Railroad station.