In the opening game of the 1966 World Series against the Los Angeles Dodgers, Drabowsky entered the game in the third inning with one out and the bases loaded after starter Dave McNally was taken out of the game. After striking out the first batter, he walked Jim Gilliam to force in Lou Johnson for a run to cut Baltimore's lead to 4–2. That would be the last run the Dodgers scored in the entire series, however, as the Orioles would sweep them 4–0, the Orioles' next three wins coming on shutouts from Jim Palmer, Wally Bunker, and McNally. Drabowsky set a one-game World Series record for relievers by striking out 11 batters, and he tied Hod Eller's 47-year record of six consecutive fans in the 1919 World Series.