In 2002, construction began on a bypass route for US 222 and PA 100 around Trexlertown. On September 29, 2005, PA 100 was rerouted to bypass the community to the west along the four-lane divided Trexlertown Bypass. US 222 was moved onto the bypass on September 28, 2007 following the extension of the bypass east to allow US 222 to bypass the community. The bypass cost $144 million to build. The former alignment of US 222 through Trexlertown along Hamilton Boulevard was designated SR 6222.