Substances known to be potentially dangerous include aconite, secretions from the Asiatic toad, powdered centipede, the Chinese beetle ("Mylabris phalerata", Ban mao), and certain fungi. There are health problems associated with "Aristolochia". Toxic effects are also frequent with "Aconitum". To avoid its toxic adverse effects "Xanthium sibiricum" must be processed. Hepatotoxicity has been reported with products containing "Reynoutria multiflora" (synonym "Polygonum multiflorum"), glycyrrhizin, "Senecio" and "Symphytum". The evidence suggests that hepatotoxic herbs also include "Dictamnus dasycarpus", "Astragalus membranaceous", and "Paeonia lactiflora"; although there is no evidence that they cause liver damage. Contrary to popular belief, "Ganoderma lucidum" mushroom extract, as an adjuvant for cancer immunotherapy, appears to have the potential for toxicity.