The Roadhouse is destroyed by demons in "All Hell Breaks Loose, Part One", and her whereabouts are unknown throughout the episode. It is revealed in "Part Two" that she had left the Roadhouse to run a few errands. She, the Winchesters, and fellow hunter Bobby Singer track Azazel's activities to a cemetery surrounded by a giant devil's trap made of railroad tracks. Unable to step inside the giant symbol without becoming trapped and powerless, Azazel forces the human Jake Talley to do his bidding. The hunters are unable to stop Jake from opening a gateway to Hell in a mausoleum there, and the devil's trap is broken as hundreds of demons are released into the world. As the brothers then kill Azazel, Ellen and Bobby close the gateway.