About from the center of Brownville, NY 12E intersects with CR 53 (Cemetery Road), an east–west highway linking the state route to the nearby village of Dexter. NY 12E continues on, passing just east of Dexter Cemetery and traversing an undeveloped rural area to reach the hamlet of Limerick. Within the community, it serves mostly residential areas and remains two lanes wide. In the center of the hamlet, the highway intersects with NY 180, a road leading to Dexter in the south and the Thousand Islands region in the north. Also present at the junction is the Seaway Trail, a National Scenic Byway that enters from the south on NY 180 and exits to the west on NY 12E. NY 12E leaves Limerick after this junction and continues through the town of Brownville, bending slightly to the northeast at a junction with CR 59 (North Shore Road) from Limerick at the Brownville–Lyme town line.