A deadly tornado struck Melissa on April 13, 1921, killing 13 people and injuring many more. The tornado tore the roof off of the brick school building, but the children inside were not seriously injured. However, all churches in the town, three cotton gins, every business house except a bank, the post office, and the Houston and Texas Central railway station, were wrecked. The Waldon Hotel was lifted by the winds, turned halfway around, and thrown up against the school building.