In the Upper Hill section of the city, PA 380 turns east becoming Baum Boulevard. In East Liberty, the route splits into one-way pairs around a large traffic circle known as Penn Circle. PA 380 exits the circle onto Penn Avenue running southeast into the Larimer neighborhood. In Point Breeze, PA 380 overlaps PA 8 for two blocks, from Fifth Avenue to Dallas Avenue; PA 380 turns north onto Dallas Avenue while PA 8 continues on Penn Avenue. In the Homewood South area, PA 380 turns east onto Bennett Street. A few miles east, the route becomes Frankstown Road in East Hills, the easternmost neighborhood in the city Pittsburgh. Frankstown Road leads 380 out of the city and into the eastern suburban area.