Reed played cheerleader Jenelope in the 2000 teen comedy film "Bring It On", her first acting role. She described the character as "the one with the attitude" and "ghetto and cute at the same time". She appeared alongside Williams and Fears, who played LaFred and Lava, friends to lead character Isis (played by Gabrielle Union). Reed, Williams and Fears would often look into the camera when delivering their lines, because of their lack of acting experience. Blaque contributed two songs to the film's soundtrack: "As If" and a remix of "Bring It All to Me" featuring verses from rapper 50 Cent. On the 15th anniversary of its release, Union said that people erroneously associate Reed's lines ("Let's beat these Buffys down" and "You been touched by an angel, girl") with her character.