Sworn in to the Seventy-fifth Congress, Izac advocated for non-interventionalism in World War II. In his first speech on the House floor, Izac said the path the nation was on would lead to its involvement in the conflict, which elicited substantial coverage from the "New York Times". Among other acts, he introduced legislation calling for the protection of the Palomar Observatory, establishment of a U.S. Marine Corps hospital in San Diego, aid for construction of public schools and to add a battalion of African American soldiers in the then-segregated California Army National Guard. Veterans were a substantial focus of his legislative efforts. He introduced legislation including disabled veterans and their families in New Deal and other appropriations. He was a delegate to the Democratic National Conventions in 1940 and 1944.