East of Stroud, SH-66 passes into Creek County. The highway passes through the town of Depew northeast of Stroud. The route next passes through Bristow, where it has a brief concurrency with SH-16 and begins a more lengthy one with SH-48. SH-48/66 exit Bristow to the north, with an interchange where they cross the Turner Turnpike. Near unincorporated Bellvue, SH-66 splits away from SH-48 and turns back to the northeast. The highway crosses the Turner Turnpike again (with no interchange this time), then runs through Kellyville. Four miles (6.4 km) northeast of Kellyville, the highway begins a concurrency with SH-33. SH-33 and SH-66 will remain signed together as they enter the Tulsa metropolitan area.