Mazzante was selected in the second round of the 2004 WNBA Draft by the Charlotte Sting, where she spent three seasons as a reserve guard. She scored a WNBA-career-high 18 points in an August 18, 2006, game against the Phoenix Mercury. After the Charlotte Sting folded in January 2007, Mazzante was selected in the 2007 WNBA Dispersal Draft by the Mercury. She contributed to the Mercury's victory in the 2007 and 2009 WNBA Finals, primarily as a three-point shooting specialist. During her Phoenix Mercury days, Mazzante wrote a blog for PhoenixMercury.com called "Maz's Musings."