In his sophomore season of 2000–01, Tanguay improved to 77 points and finished sixth in the NHL in plus/minus at +35. He enjoyed an 11-game point streak in November 2000, scoring six goals and 13 assists in that span. He was a key contributor for the Avalanche in the post-season, recording 21 points. In game seven of the 2001 Stanley Cup Finals, Tanguay scored two goals, including the game-winner, and added an assist in a 3–1 victory against the New Jersey Devils. His efforts led Colorado to its second Stanley Cup championship in franchise history.