In the 1966 off-season Reina joined FC Barcelona, appearing in only four league games in his first three years combined as he acted as understudy to both José Manuel Pesudo and Salvador Sadurní. From 1969–70 onwards he became first-choice, going on to win his second Copa del Rey with the Catalans – the first as an active member – and adding the Ricardo Zamora Trophy for the 1972–73 campaign (all 34 matches played for the runners-up and only 21 goals conceded, posting a record of 824 minutes without a goal which would last until 1 November 2011 when he was surpassed by Víctor Valdés).