After an overhaul at New York, "Refuge" departed on 1 November 1944 for South Pacific duty with the Service Force, 7th Fleet. After stopping at Humboldt Bay, Dutch New Guinea, on 16 December, she continued on three days later for the Philippines. Arriving San Pedro Bay, Leyte, on Christmas Eve, she commenced the embarkation of patients from small landing craft. By 30 June 1945 she had made six voyages from that area to deliver her casualties to either Hollandia, New Guinea or Seeadler Harbor, Manus, the Admiralties. She departed Seeadler Harbor on 1 July for Manila, where she received patients from various fleet units through to the end of August 1945.