At first, the Company served the needs of the sick and poor in their homes. Louise's work with these young women developed into a system of pastoral care at the Hôtel-Dieu, the oldest and largest hospital in Paris. Their work became well-known, and the Daughters were invited to Angers to take over management of the nursing services of the hospital there. As it was the first ministry outside Paris for the fledgling community, Louise made the arduous journey there in the company of three nuns.