Kuroda pitched as the team's opening-day starter for the 5th consecutive year in 2007. He marked his 100th career win on July 14, 2007 against the Yomiuri Giants at the Tokyo Dome (his first professional win was also at the Tokyo Dome). Though Kuroda had been most effective during the summer in past years, he struggled to make quality starts during the later half of the season, perhaps due to the surgery he had received during the off-season. He ended the season with a 12–8 record, with a 3.56 ERA.