During the "Civil War II" storyline, Medusa and Crystal introduce the Inhuman Ulysses to Captain Marvel, War Machine, and Black Panther. Medusa later catches Iron Man infiltrating New Attilan to claim Ulysses and fails to reason with him. After Iron Man defeats Medusa, Crystal, and Karnak and makes off with Ulysses, Medusa leads some Inhumans to Stark Tower to confront Iron Man which led the Avengers, the Ultimates, S.H.I.E.L.D., and other superheroes to intervene. Medusa was present when Ulysses projected his latest vision of a rampaging Hulk standing over the corpses of the superheroes.