Upon its release, "Te Lo Agradezco, Pero No" was perceived as an album highlight by several music critics. It earned the duo multiple awards and nominations, including Song of the Year at the 2007 Premios Oye!. Commercially, the single was successful in Venezuela and on the American Latin music charts, where it topped the "Billboard" Hot Latin Songs and Latin Pop Airplay charts. A music video for the song, directed by Jaume de Laiguana, was filmed in Brooklyn and released on 11 January 2007. It is a continuation of the clip for Sanz's "A la Primera Persona" and it features the duo dancing together towards the end. Sanz performed the song live during his El Tren De Los Momentos Tour (2007–08).