After the U.S. entered World War I, Florence occupied herself in working toward a victory. She helped Ohio women who moved to Washington, D.C. for jobs find housing, and helped Lou Hoover set up dining and recreation spaces for the female workers. Florence frequently visited nurseries and daycare centers to assist mothers who had to work during the day. Alongside other political spouses, she handed out tin cups of coffee and sandwiches to soldiers departing from Union Station. Florence also volunteered at the Walter Reed Hospital, and found a sense of satisfaction in this work missing from her heretofore existence. She worked with other Senate wives to create a Red Cross Unit and produce clothing for soldiers on the battlefield. In order to better monitor the events on the front, Florence avidly read several newspapers and learned the pronunciation of foreign towns and locations.