Larrys Creek then enters Piatt Township, flowing east around a ridge and through the village of Larryville where it receives Seeley Run on the left bank, from the mouth. It next flows back southwest, then south to the hamlet of Larrys Creek and finally into the West Branch Susquehanna River, east of the borough of Jersey Shore, at an elevation of . U.S. Route 220 and the Lycoming Valley Railroad cross the creek on separate bridges just north of its mouth. The direct distance between the source and mouth is only . The difference in elevation between source and mouth, , divided by the length of the creek, , gives the average drop in elevation per unit length of creek or relief ratio of 53.5 feet per mile (10.1 m/km). The meander ratio is 1.08, so the creek is fairly straight in its bed.