To accommodate this activity, growth cones are believed to pool mRNAs that code for receptors and intracellular signaling proteins involved in cytoskeleton remodeling. In Xenopus retinotectal projection systems, the expression of these proteins has been shown to be influenced by guidance cues and the subsequent activation of local translation machinery. The attractive cue Netrin-1, stimulates mRNA transport and influence synthesis of β-Actin in filopodia of growth cones, to restructure and steer RGC growth cones in the direction of Netrin secretion. While the repulsive cue, Slit, is suggested to stimulate the translation of Cofilin (an actin depolymerizing factor) in growth cones, leading to axon repulsion. In addition, severed commissural axons in chicks, display the capability of translating and expressing Eph-A2 receptor during midline crossing. As a result, studies suggest that local protein expression is a convenient mechanism to explain the rapid, dynamic, and autonomous nature of growth cone advancement in response to guidance molecules.