In 1964, Cahn became a professor in the Department of Metallurgy (now Materials Science) at the Massachusetts Institute of Technology. He left MIT in 1978. In 1969, Cahn began a long professional relationship with his graduate student, Francis Larché, whose work focussed on the effect of mechanical stress on the thermodynamics of solids. The Larche–Cahn approach is the cornerstone of the treatment of the thermodynamics of stressed materials. Good examples of this phenomenon are the regions near a coherent precipitate or the stress field around a dislocation.