Indigenous resistance was weakened by continual warfare with the Spaniards and disease. By 1530 almost all of the indigenous peoples of the area had been subdued with the exception of the Lacandons in the deep jungles who actively resisted until 1695. However, the main two groups, the Tzotzils and Tzeltals of the central highlands were subdued enough to establish the first Spanish city, today called San Cristóbal de las Casas, in 1528. It was one of two settlements initially called Villa Real de Chiapa de los Españoles and the other called Chiapa de los Indios.