Wilk started his career as a drummer for Greta in 1990, and helped co-found Rage Against the Machine with Tom Morello and Zack de la Rocha in August 1991. Following that band's breakup in October 2000 Wilk, Morello, Rage Against the Machine bassist Tim Commerford, and Soundgarden front man Chris Cornell formed the supergroup Audioslave, which broke up in 2007. As of 2016, he is playing in the band Prophets of Rage, with Commerford, Morello, Chuck D, B-Real and DJ Lord.