This development would lead to the development of an algorithm which would help to identify the conserved regions of pathogen sequences and in turn would be useful for vaccine development. This would be helpful in limiting the spread of infectious disease. Examples include a method for identification of vaccine targets from protein regions of conserved HLA binding and computational assessment of cross-reactivity of broadly neutralizing antibodies against viral pathogens. These examples illustrate the power of immunoinformatics applications to help solve complex problems in public health. Immunoinformatics could accelerate the discovery process dramatically and potentially shorten the time required for vaccine development. Immunoinformatics tools have been used to design the vaccine against SARS-CoV-2, Dengue virus and Leishmania.