In May 2007, it was announced that Gamble had again been drafted into Steve Staunton's Republic of Ireland squad to travel to the United States to take part in friendly matches against Ecuador and Bolivia. He made his international debut against Ecuador on 23 May 2007 at the Giants Stadium, and having suitably impressed, he started the game against Bolivia three days later at the Gillette Stadium, thus becoming the first home-based player to feature in a Republic of Ireland starting eleven since Glen Crowe's appearance against Greece in 2002.