López was married to Argentine model Wanda Nara from 2008 to 2013. The couple have three sons, Valentino Gastón (born 25 January 2009), Constantino (born 19 December 2010) and Benedicto (born 20 February 2012). Nara and López split after her affair with López's former Sampdoria teammate Mauro Icardi, now with Paris Saint-Germain, was exposed. López had previously been good friends with Icardi, inviting his countryman on vacations and opening his home to Icardi when he first moved to Italy. She and López began divorce proceedings in December 2013. Nara and Icardi subsequently married on 27 May 2014. During the April 2014 Serie A match between Sampdoria and Inter, López notably refused to shake Icardi's hand, leading the press to dub the game the "Wanda derby".