In the Champions League group round match against PSV Eindhoven on 24 October 2018, Lloris was sent off after a challenge late in the game that ended in a 2–2 draw. On 2 March 2019, Lloris saved a late penalty in the North London Derby, and kept the score at 1–1. A few days later on 5 March 2019, in the Champions League last-16 away tie against Borussia Dortmund, Lloris made a number of crucial saves to kept a clean sheet, which ensured a 4–0 win on aggregate and progress to the club's second quarterfinal in the Champions League. This is his 100th clean sheet with the club. He also kept a clean sheet in the home leg of the quarter-final against Manchester City, saving a penalty in a 1–0 win that helped keep Tottenham in the competition. The previous week in the Premier League match against Liverpool, he made a goalkeeping error which let in a late goal and lost 2–1.