On November 16, Fitzgerald had ten receptions for 151 yards against the Seattle Seahawks in a 26–20 Week 11 victory. On November 27, he had his second multi-touchdown game of the season, this time in a 65-yard performance against the Philadelphia Eagles in a 48–20 loss. Fitzgerald finished the regular season strong with three receptions for 101 yards including a 76-yard touchdown against the New England Patriots in a 47–7 loss, and five receptions for 130 yards and two touchdowns against the Seattle Seahawks in a 34–21 victory in the regular season finale.