Dufresne was a James Beard Foundation nominee for Rising Star Chef of the Year in 2000 and chosen the same year by New York Magazine for their New York Awards. Food & Wine magazine named him one of 2001 America's Ten Best Chefs award and, in 2006, New York Magazine's Adam Platt placed wd-50 fourth in his list of New York's 101 best restaurants. He was awarded a star in Michelin's New York City Guide, 2006, 2007, 2008, the first Red Guide for North America, and was nominated for Best Chef New York by the James Beard Foundation. Among his signature preparations are Pickled Beef Tongue with Fried Mayonnaise and Carrot-Coconut Sunnyside-Up.