Breaking into the majors with the Red Sox in 1909, Hooper played in 81 games and hit .282. Between 1910 and 1915, he teamed with Tris Speaker (CF) and Duffy Lewis (LF) to form the Golden Outfield, one of the finest outfield trios in baseball history. Religious differences may have been the biggest challenge for the Golden Outfield. At the time, a common Protestant sentiment was that Catholics would move to their communities and change the established culture. Speaker, who was a Protestant, once went a year without speaking to Hooper or Lewis, who were both Catholic.