Despite his resignation from the Knesset, Deri headed the Shas list for the March 2015 elections, and was subsequently appointed Minister of the Economy and Minister of the Development of the Negev and Galilee in the new government. He left his post as Minister of the Economy on 3 November 2015, reportedly over an unpopular gas monopoly deal, and was replaced by Netanyahu, who promised to speed up the deal. He was appointed Minister of the Interior on 11 January 2016. He resigned from the Knesset in October 2016 to allow Michael Malchieli to take his seat, whilst remaining a minister. He temporarily served as Minister of Religious Services in 2018 after the death of David Azulai. Israeli police recommended on 20 November 2018 that he be indicted for "committing fraud, breach of trust, obstructing court proceedings, money laundering, and tax offenses."