Frosinone's maiden Serie A campaign began in a difficult style, losing their first four outings and dropping to bottom place in the table. In Round 5, the club came up against Italian football heavyweights Juventus at the Juventus Stadium. Defying all odds, Frosinone came away with their first ever Serie A point thanks to an equalising last minute Leonardo Blanchard header to end the match in a 1–1 draw. The following round, Frosinone achieved their first Serie A win, defeating Empoli 2–0 at the Stadio Matusa. Frosinone went on to pick up their second and third consecutive home wins by beating Sampdoria by the same scoreline as Empoli and fellow newly promoted side Carpi 2–1. Frosinone Calcio were relegated back to Serie B after one season in Serie A as they finished in 19th place.