In August 1834, Crandall married the Rev. Calvin Philleo, a Baptist minister in Canterbury, Connecticut. The couple moved to Massachusetts for a period of time after they fled the town of Canterbury, and they also lived in New York, Rhode Island, and Illinois. Crandall was involved in the women's suffrage movement and ran a school in LaSalle County, Illinois. She separated from Philleo in 1842 after his "deteriorating physical and mental health" led him to be abusive. He died in Illinois in 1874.