In "Ghostbusters", Janine is hired as the secretary of the Ghostbusters, where she keeps tabs on the clients. She also interviews Winston Zeddemore for the job as the fourth member of the team. Later, she helps Egon interviewing Louis Tully who was possessed by Vinz Clortho, the Keymaster of Gozer. After the battle with Gozer, she is seen outside of 55 Central Park West, hugging Egon, happy to see him alive and well, joining the rest of the Ghostbusters as they drive off in the Ecto-1.