On January 2, 2016, Lopez recorded a then season-high 30 points and 13 rebounds in a 100–97 win over the Boston Celtics. Two days later, he was named Eastern Conference Player of the Week for games played Monday, December 28 through Sunday, January 3. On January 24, he scored a season-high 31 points in a 116–106 win over the Oklahoma City Thunder. He topped that mark six days later, recording 33 points and 10 rebounds in a 105–103 loss to the New Orleans Pelicans. On February 19, he tied his season-high of 33 points in a 109–98 win over the New York Knicks. He moved past Richard Jefferson (8,507 points) into third place on the Nets' career scoring list. On March 24, with 22 points against the Cleveland Cavaliers, Lopez moved past Vince Carter into second place on the Nets' career scoring list with 8,835 points.