Tucci's first wife, Kathryn "Kate" Spath-Tucci (b. 1962), died of breast cancer in 2009. She was a social worker and former wife of actor and stage manager Alexander R. Scott, the elder son of actors Colleen Dewhurst and George C. Scott. She and Tucci married in 1995 and had three children. The couple also raised Kate's two children from her previous marriage. Tucci left her in 2002 for actress Edie Falco, with whom he was appearing on Broadway in Terrence McNally's "Frankie and Johnny in the Clair de Lune", but the affair ended, and he returned to his wife and children.