In 2006, despite a slow start to the season due to a dislocated toe from an off the field incident at a night club in Little Rock, McFadden rushed for a school-record 1,647 yards, the fifth best all-time in the SEC for single season yards, scored 14 touchdowns, and threw for three more touchdowns on just nine passing attempts, becoming a first-team All-American. McFadden also attained a new career high for yards in a single game in his 219-yard performance in a 26–20 win against South Carolina. Thanks to his efforts, Arkansas streaked to ten wins and the SEC Western Division Championship, but lost to Wisconsin in the Capital One Bowl on January 1, 2007 and finished with a record of 10 wins and 4 losses.