In 2006, Floyd caught a 31-yard touchdown pass against the Baltimore Ravens, on a play in which Samari Rolle slipped and fell in coverage. He caught a touchdown pass for the second time in two weeks with a nine-yard tip-toe catch in the back corner of the end zone against Pittsburgh. Floyd caught a career-long 46-yard touchdown pass in the third quarter of the win against the Cincinnati Bengals. He was selected as the Chargers Alumni Player of the Week following the game in Cincinnati, after substituting for Eric Parker who was out with a neck injury. Floyd left Cincinnati with his first career 100-yard game, making five catches for 109 yards and a touchdown. He was inactive for Week 13 game against Denver game with an ankle injury. Floyd was placed on injured reserve due to the ankle injury on December 14.