The city benefited from being a stagecoach stop of the Santa Fe and Oregon trails, and later from the Missouri–Kansas–Texas Railroad. In 1822, William Jewell set up the first hospital. In 1830, the first newspaper began; in 1832, the first theater in the state was opened; and in 1835, the state's first agricultural fair was held. By 1839, the population of 13,000 and wealth of Boone County was exceeded in Missouri only by that of St. Louis County, which, at that time, included the City of St. Louis.