She next portrayed the grasping Grace Baker (the mother-in-law of Penny Hughes Baker on "As the World Turns" from 1959 to 1962, and Rose Pollack (the kind-hearted mother of Nancy Pollock Karr) on "The Edge of Night" in 1964. Reid portrayed matriarch Alice Horton on NBC's "Days of our Lives" since the show's premiere on November 8, 1965. Reid gained mainstream attention for a 2003–2004 storyline in which Alice and several other long-running characters were seemingly murdered. Her last appearance on "Days of our Lives" was on December 26, 2007 although she remained on contract with the show until her death.