After the death of Edward VI, Herbert initially supported Lady Jane Grey's claim to the throne. Herbert arranged the marriage of his eldest son and heir, Henry, to Jane's sister, Lady Catherine Grey, at Durham House on 25 May 1553, the same day as her sister Jane was married to Guilford Dudley. The third couple married that day was the Duke of Northumberland's youngest daughter, Katherine, to Henry Hastings, 3rd Earl of Huntingdon. When it became clear that Lady Mary Tudor would take the throne as Mary I, he cast his daughter-in-law, Catherine, out of his house and had the marriage annulled. Lady Catherine's father and sister, Jane, were both executed for high treason in February 1554 by the orders of Queen Mary I. Herbert managed to distance himself from the Grey family after their fall and obtained the new queen's favour by crushing Thomas Wyatt's rebellion.