The development of the University came to a standstill at the end of the seventeenth and during the eighteenth century because of theological differences of opinion, a difficult relationship with the Regional Assembly and political problems that included the siege of the city by ‘"Bommen Berend"’ in 1672. On average two to three hundred students were registered with the University at any one time during this period. Petrus Camper, though, was a shining academic example during the second half of the eighteenth century and was famous far beyond the city limits as an anatomist, a fighter against rinderpest and the founder of the first outpatient's clinic for surgical medicine.