In 1992, Rhéaume was signed by the Atlanta Knights of the International Hockey League (IHL). Her first appearance against the Salt Lake Golden Eagles marked the first time a woman appeared in a regular season professional game. She played for seven different teams between 1992 and 1997, including Atlanta, the Knoxville Cherokees, Nashville Knights, the Las Vegas Aces, the Tallahassee Tiger Sharks, Las Vegas Thunder, and the Reno Renegades, appearing in a total of 24 games. While in Atlanta, Rhéaume wrote her autobiography, "Manon: Alone in Front of the Net". She initially retired from professional hockey in 1997.