"Missamma"/"Missiamma" was the first bilingual film from Vijaya Vauhini Studios with different male actors in different versions, in contrast to "Pathala Bhairavi" (1951) and "Pelli Chesi Choodu" (1952) where the same actors were used in both versions. The producers cast N. T. Rama Rao as the male lead in the Telugu version and Gemini Ganesan (then known as R. Ganesh) replaced him in Tamil, while P. Bhanumathi was initially cast as the female lead in both versions. S. V. Ranga Rao and Rushyendramani were cast as the female lead's biological parents, and Meenakshi and Doraswamy as her foster parents, in both versions.