In 1988, two American researchers, Carpenter and Chang, suggested estimating the speed of cell division of phytoplankton by following the course of DNA replication by microscopy. By replacing the microscope by a flow cytometer, it is possible to follow the DNA content of picoplankton cells over time. This allowed researchers to establish that picoplankton cells are highly synchronous: they replicate their DNA and then divide all at the same time at the end of the day. This synchronization could be due to the presence of an internal biological clock.