In 1967, Prothro helped a second quarterback capture the Heisman Trophy when Gary Beban was awarded the trophy after the regular season. He would bring his No. 1 ranked UCLA Bruin team to face No. 2 USC in one of the "Games of the Century". Despite playing with cracked ribs, Beban threw for 301 yards, but UCLA lost, 21–20, on a spectacular 64-yard run by O. J. Simpson in the 1967 USC vs. UCLA football game. Another big factor was UCLA's acclaimed sophomore kicker Zenon Andusyshyn missing a chip shot field goal, and having two field goals and an extra point attempt blocked. In what was acknowledged to be a rebuilding year, the Bruins opened the 1968 season with a 63–7 defeat of Pittsburgh and a win over Washington State. The season ground to a halt at Syracuse and with the season-ending injury of quarterback Billy Bolden, and UCLA would win only one more game, over Stanford 20–17. The Bruins gave No. 1 USC and Heisman Trophy winner O. J. Simpson a scare in a 28–16 loss; UCLA trailed 21–16 late in the fourth quarter and had the ball inside USC's 10-yard line, but USC recovered a fumble and then used almost all of the remaining time in driving for their insurance touchdown.