Deen's home business, The Bag Lady, soon outgrew her kitchen. She first moved into the Best Western on Savannah's southside on Abercorn Street in 1991 with a restaurant called The Lady. In January 1996, Deen opened her restaurant, The Lady & Sons, in downtown Savannah, on West Congress Street. Within a few years, the restaurant moved to the old White Hardware building on Whitaker. "USA Today" named The Lady & Sons the "International Meal of the Year" in 1999. The specialty is a buffet of Southern "comfort foods".