In 1923 he was registered at the college in Pavia as a general practitioner in medicine. He later arrived in Morimondo to practice medicine where he gave valuable assistance to the parish priest and helped him to set up a musical band and a Catholic Action Youth Club of which he was the first president. He was also the secretary of the Parish Missionary Aid Society and he founded the Band of Pius X which he dedicated to the medical care of the poor whom he treated for free. Pampuri would soon leave his practice to become a religious after seeing that his call to the religious life was far too great to ignore.