US 250 enters the city of Richmond adjacent to The Shops at Willow Lawn, where the GRTC Pulse bus rapid transit line begins following the road from its terminus at the Willow Lawn station. Soon after entering Richmond, the road comes to an intersection with US 33 (Staples Mill Road), where US 33 joins US 250 on Broad Street. The two highways parallel the city line to SR 197 (Malvern Avenue), then pass over I-195 with no access. US 33 and US 250 intersect SR 161 (Boulevard) northwest of the Science Museum of Virginia, in the former Broad Street railroad station. US 33 and US 250 split just east of the Siegel Center, home of the Virginia Commonwealth University Rams basketball teams, with US 250 continuing on Broad Street, while US 33 turns north onto Hancock Street. The highway intersects US 1 and US 301 at Belvidere Street, then passes through Downtown Richmond, including such buildings as the Masonic Temple, Carpenter Theater, the Library of Virginia, and the Old City Hall, which is one block north of the Virginia State Capitol and the Executive Mansion. US 250 passes by the headquarters of the Virginia Department of Transportation at its trumpet interchange with I-95 (Richmond–Petersburg Turnpike) at 14th Street. The GRTC Pulse line splits from Broad Street to follow 14th Street south. The highway passes to the north of Richmond's historic Main Street Station, then reaches its eastern terminus at US 360, which heads south along 17th Street and north on 18th Street. Broad Street continues east as an unnumbered city street through the city's Church Hill neighborhood.