Displaying a drop to one knee, Beltré hit a home run on a curve ball from Jesse Hahn of Oakland on May 17. In a May 29 game against the Pittsburgh Pirates, Beltré hit a two-run home run off Juan Nicasio to give him 1,501 career RBI, making him the 54th player to reach the milestone, and the fourth third baseman. On July 2, 2016, Beltré became the 28th player all time to amass 10,000 career at-bats. On July 23, 2016, he became the 36th player all time to record 11,000 career plate appearances. Two days later, he hit the walk-off home run, the ninth of his career, against the Athletics in the bottom of the ninth inning for a 7−6 win.