During a 77 game career with the Eagles, Mamula had 209 total tackles and 31.5 sacks. His best seasons were 1996 and 1999. In 1996, he logged 8 sacks and in 1999 he had 8½, after recovering from missing the entire 1998 season. He also picked off a pass from Kurt Warner and returned it for a touchdown in the last game of the 1999 season. He was forced to retire after the 2000 season due to injuries. Mamula was inducted into Boston College's Sports Hall of Fame.