PA 380 begins along the ramps of the Bigelow Boulevard and Interstate 579 interchange in Downtown Pittsburgh, north of the former Civic Arena complex. The route proceeds east traversing Ammon Playground park in the Hill District. PA 380 also parallels Norfolk Southern's Pittsburgh Line and the PAAC's Martin Luther King Jr. East Busway on this section of the four-lane Bigelow Boulevard. In the neighborhood of Polish Hill, PA 380 intersects the Bloomfield Bridge via eastbound ramp and westbound at-grade intersection; the bridge connects to Liberty Avenue and the Bloomfield neighborhood.