Upon O'Neil's return to Marvel Comics in 1980, he took on the scripting chores for "The Amazing Spider-Man", which he did for a year. O'Neil wrote two issues of "The Amazing Spider-Man Annual" which were both drawn by Frank Miller. The 1980 "Annual" featured a team-up with Doctor Strange while the 1981 "Annual" showcased a meeting with the Punisher. He and artist John Romita Jr. introduced Madame Web in "The Amazing Spider-Man" #210 and Hydro-Man in #212. O'Neil was the regular scripter for "Iron Man" from 1982–1986 and "Daredevil" from 1983–1985. During his run on "Iron Man", O'Neil introduced Obadiah Stane, later the Iron Monger, plunged Tony Stark back into alcoholism, turned Jim Rhodes into Iron Man, and created the Silver Centurion armor. O'Neil's run on "Daredevil" bridged the gap between Frank Miller's two runs on the title, usually with David Mazzucchelli as artist. He introduced Yuriko Oyama during his stint, who would later become the popular X-Men villain Lady Deathstrike. While working for Marvel, he helped write the original character concept for the Transformers, and is credited as the person who named Optimus Prime.