Lloris remained consistent during the 2010 portion of the season conceding only two goals in the club's first four matches of the year with Lyon winning all of them and Lloris picking up two clean sheets. On 16 February, Lloris earned a clean sheet in Lyon's first leg of its UEFA Champions League knockout round match against Real Madrid. Lloris made two saves in the team's 1–0 victory making a finger-tipping save from a deflected Cristiano Ronaldo shot in the 61st minute and producing a reflex save on a shot from Gonzalo Higuaín three minutes later to keep Lyon ahead on the scoreline. Lyon later achieved qualification to the quarterfinals in the competition after drawing 1–1 in Madrid with Lloris conceding the opening goal to Cristiano Ronaldo in the sixth minute. It was the goalkeeper's first goal conceded in over 620 minutes. On 2 May, Lloris provided the assist on the game-winning goal scored by Michel Bastos in Lyon's 1–0 win over Montpellier. A week later, he was named, for the second consecutive season, the UNFP Ligue 1 Goalkeeper of the Year.