The local area had a significant Native American population. The Pawnee Indians resided west of Hanover, the Kansa and Kaw tribes lived to the south, and the Otoe Indians were located north. The Otoe Reservation resided north of Hanover on the Kansas-Nebraska border from 1854 to 1883. Their reservation was 160,000 acres large (250 mi2). When the Otoe tribal lands were sold in 1883, the land sold for a record-high average of $12.22 per acre. By comparison, most other Native American tribes in the central and northern Great Plains were only paid ten cents per acre. Some of the Otoe Indians were relocated to Red Rock, Oklahoma, while many of the mixed-race Otoe Indians were integrated with the local German settlers. Many people in Hanover today have a fraction of Native American ancestry.