The 2008 season marked a huge year for Fitzgerald in terms of individual accomplishment and team success. In the season opener against the San Francisco 49ers, Fitzgerald caught a one-yard receiving touchdown in the 23–13 victory. In the second game of the season, he had six receptions for 153 yards against the Miami Dolphins in a 31–10 victory. He followed that up with seven receptions for 109 yards against the Washington Redskins in the next game, a 24–17 loss. He posted his third consecutive game with at least 100 receiving yards in the next game against the New York Jets with 122 receiving yards on eight receptions a 56–35 loss. In the next game, he was held to only 52 yards, but had two receiving touchdowns in a 41–17 victory over the Buffalo Bills.