Like all Nikon SLRs, the F-501 accepts Nikon's F-mount lenses, but will only autofocus with lenses designated "AF." Likewise, fully automatic exposure will only work with AI-S type lenses, including many autofocus lenses (G-type lenses are not supported by the F-501). In both cases, the camera will function with lenses without these abilities, but will not autofocus or may not have full auto exposure capabilities. AF lenses designated "D" add no functionality to the F-501, and "AF-S" and "VR" lenses will not perform their special functions if attached to an F-501.