In 2004, George W. Bush flipped the county from blue to red, albeit narrowly, and since then, the county has solidified its standing as a Republican bastion. As of 2020, the county has voted Republican five times in a row, with the Republican vote share increasing in every election. In 2008, Pemiscot County swung the most Republican of all the counties in the state, as McCain improved on Bush's vote share by fully 6.2%, already besting not only Bush but every Republican to have carried the county in at least the prior hundred years apart from Nixon in 1972. In 2020, Donald Trump posted the best showing for a Republican in the county in at least over a century, with his nearly 72% exceeding Nixon's 70%.