Holliday started all 16 games for the second straight season in 2006. In one of the best seasons of his career, Holliday amassed 66 tackles, seven sacks, a fumble recovery and a pass defensed. Holliday's seven sacks in 2006 ranked second on the team behind only Defensive Player of the Year Jason Taylor's 13.5, and also ranked third in the league among defensive tackles. It was also the highest total for a Dolphins player at the position in more than two decades.