Alex (Allen Covert) is a single, 35-year-old video game tester who lives with his friend Josh (Jonathan Loughran). When Josh wastes their rent money on Filipino hookers, their landlord Yuri (Rob Schneider) evicts them, and Alex has to find a new place to live. Alex tries to stay with his marijuana dealer Dante (Peter Dante), but cannot do so because Dante is adopting a wild lion to live in the house. Alex spends one night with his co-worker Jeff (Nick Swardson), but Jeff still lives with his parents. After an embarrassing "encounter" with Jeff's mom, in which he is caught masturbating in the bathroom and subsequently ejaculates on her, Alex is forced to move in with his grandmother Lilly (Doris Roberts) and her two eccentric friends, Bea (Shirley Knight) and Grace (Shirley Jones).