In June 2010, Lewis' distinctive voice was in fine form as she told The Jazz Joy and Roy syndicated radio show, "I just did a production of 'Hello Dolly' at the 5th Avenue Theatre in Seattle and it had to be one of the greatest productions that I have ever done, because I got to just do a character, Dolly Levi, and it was just great." In 2012 Lewis began working with Shangela on the online reality show parody, "Jenifer Lewis and Shangela," where she acts as herself alongside Shangela, a "drag queen living in her basement." She later appeared in Shangela's music video for "Werqin Girl (Professional)."