The strip focuses on the adventures of a creative little boy, Liō, who lives with his father (unnamed in the strip) and various monsters, animals, aliens, lab creations, and other creatures. Liō's mother is deceased. It is currently unknown how she died. The setting of the story varies from Liō's house to his school and the general outside world. The time period appears to be contemporary, except for an episode set in the year 2101, when Liō is in his nineties but still very much capable of mischief.