Tanox became the first major acquisition of Genentech in an all-cash buyout deal (US$919 million) in August 2007 (Genentech itself became wholly owned by Roche in March 2009). The acquisition of Tanox has boosted Roche/Genentech's product pipeline substantially. In addition to the enhancement of the anti-IgE franchise by the increased rights on Xolair (omalizumab) and by the potential utility of TNX-901 (Talizumab), the other pipeline products that have gained considerable prominence include TNX-355 (Ibalizumab), a unique anti-CD4 antibody for treating AIDS, TNX-650 (Lebrikizumab), an anti-interleukin-13 antibody for treating asthma, and TNX-224, an Fab fragment of a humanized antibody against Factor D of the human immune complement system to be tested for treating geographic atrophy associated with dry age-related macular degeneration. Based on Tanox's invention of the “anti-CεmX (also referred to anti-M1’) approach”, Genentech is developing Quilizumab, an antibody specifically targeting mIgE on B cells, for asthma and allergic diseases.