In Cleveland, SH 321 is also known as Houston Street, providing the main street for downtown Cleveland. It is a two lane urban highway with a left turn lane as it travels throughout Cleveland, until roughly 3/4 of a mile northeast of the city limit. From Loop 573, on southward until junction with SH 105, SH 321 is also known as SH 105. In the city of Dayton, it is referred to as North Cleveland Street, passing through residential Dayton as a 4-lane urban highway, before narrowing back down to a 2-lane rural State Highway.