The first burial at Bellefontaine Cemetery took place on April 27, 1850, and the official dedication followed several weeks later. Bodies from older graveyards within the city of St. Louis were moved to Bellefontaine, including some from the cemetery by the Old Cathedral near the Mississippi River. Bellefontaine was also the resting place for several victims of the 1855 Gasconade Bridge train disaster, the worst railroad disaster in Missouri history. Also interred at Bellefontaine are members of several notable brewing families, including the Anheusers, Buschs, Lemps, and Griesediecks.