After multiple COVID-19 cases within the Browns organization, which decimated the majority of their coaching staff, the Steelers were heavy favorites to win the wild-card game. However, a botched snap on the first play of the game, as well as two costly interceptions and a stop on 3rd and 1 gave the Browns a surprising 28–0 lead by the end of the first quarter. Despite an NFL-record 47 completions by Roethlisberger, Cleveland's lead was insurmountable as Pittsburgh lost 48–37, giving the Browns their first win at Heinz Field since 2003 and ending a once-promising season for the Steelers.