The first written document mentioning "Frates de Radegiz" dates from 1244. In the following centuries, the ownership changed a few times, which was mentioned in some documents. In 1612, Radegast became a princely office. In 1727 the village received market and city rights from Prince Leopold of Anhalt-Dessau, but the city rights were not exercised until 1852. From 1685 to 1688, a dam was built in the lowland of the river Fuhne between Radegast and Zörbig, which created an important trade-route between the cities of Magdeburg and Leipzig. In 1688 a boundary stone named the "Theure Christian" was set at this route. It marked the boundary between the former countries of Saxony and Anhalt-Dessau. In 1702 Radegast became a market-town, and in the same year the building of Radegast's first church began. The church-tower collapsed in 1752 and was rebuilt subsequently. Two historical guesthouses were built at that time; both of them exist today.