The gray four-eyed opossum does not "play dead" like the North American Virginia opossum. Instead it is aggressive and fights with potential predators. Some displays of aggression include opening the mouth wide and hissing loudly. It is known to be "the fiercest fighter of the opossums". The gray four-eyed opossum is a nocturnal animal but can be active during the day. Although it is terrestrial, it is very good at climbing and swimming. It has agile and swift movements, and seems more alert than other didelphids.