Valletta's first major film role was as Allegra Cole in Andy Tennant's romantic comedy "Hitch". The film was released on February 11, 2005 and was a box office and critical success. She also had a role in "Transporter 2", playing the mother of the kidnapped child. She played the female lead in the 2006 independent film "The Last Time", co-starring alongside Michael Keaton and Brendan Fraser. In 2007, she had supporting roles in the horror film "Dead Silence", as Ella Ashen, and as Claire in "Premonition", starring Sandra Bullock. Also in 2007, Valletta played the leading role in the independent coming-of-age film, "My Sexiest Year".