MS 28 heads east through farmland for several miles to have an intersection with MS 469, and crosses the Strong River, before passing through Pinola, where it has a short concurrency (overlap) with MS 43, as well as having a junction with the eastern section of MS 472. The highway takes a southeastern turn for several miles, where it has an intersection with MS 13, before heading back northeast for a few miles to enter the Magee outskirts at an intersection with MS 545. It becomes concurrent with MS 541 and they enter the city limits proper just shortly before becoming concurrent with US 49. They head southeast through a business district as a four-lane divided highway, where MS 541 splits off into downtown along Main Avenue S, before MS 28 splits off as a two-lane along Pinola Drive. MS 28 has a short concurrency with MS 149 (Simpson Highway 149) through some neighborhoods on the southern outskirts of downtown before MS 28 leaves Magee heads eastward through rural farmland for the next several miles to cross into Smith County.