Hooper had some of his best offensive production with the White Sox. He hit over .300 in three out of the five seasons he spent with the team and he hit a career-high 11 home runs and 80 runs batted in during the 1922 season. In 1922 and again in 1924, Hooper was involved in eight double plays, which led the league for outfielders in both of those seasons. In 1925, Hooper asked for his release from Chicago so that he could pursue a position as a manager.