The six-lane cross section that began at exit 1 remains through Lubbock. Major junctions in that city include U.S. Highway 62/State Highway 114 (19th Street, exit 3) and U.S. Highway 82 (Marsha Sharp Freeway, exit 4). Between these two interchanges, the frontage roads temporarily end as I-27 crosses over a rail line. Spur 326 (Avenue Q) merges with I-27 at exit 6A, and exit 6B is a split diamond interchange with Loop 289. The outer lanes leave at Farm to Market Road 2641 (Regis Street, exit 8), reducing I-27 to two lanes in each direction as it passes Lubbock Preston Smith International Airport and leaves the city.