The Nyaya-sutras have been one of the foundations for the historic debate between Hinduism's premise that ultimate reality and atman (soul) exists, and Buddhism's premise that there is voidness and anatta (no-soul). In Nyaya-sutra, the Buddhist premises and arguments to refute those premise are found in many chapters, such as sutras of chapters 3.2, 4.1 and 4.2. The text has been influential in this debate, with the 2nd-century Buddhist scholar Nagarjuna states that the Nyaya school and Buddhism differ on their conception of Self (Atman) and their views on the Vedas, and the sutra 4.2.25 of Nyayasutra is addressed against the Madhyamika system of Buddhism.