In the 1997 season, after legendary Zetti moved to Santos, Ceni was chosen as his replacement. On 14 July 2005, Ceni was São Paulo's captain as the team won the 2005 Copa Libertadores, a third for the club. Two weeks later, in a match against Atlético Mineiro, he broke the record for most appearances for the team, with 618 matches – he wore a special commemorative jersey that had the number "618" printed on the back; on 25 July of the following year, he scored a penalty against Mexican side Guadalajara (also a match-winner), becoming the "Tricolor"'s all-time leading scorer in the Libertadores.