After a disappointing 2015 season in which Hardy was plagued with injuries, he hoped to come back healthy for the 2016 season. He entered the second year of his three-year contract. On April 12, Hardy homered twice in one game and drove in five runs in a 9–5 victory over the Boston Red Sox, which helped the Orioles improve to a franchise-best 7-0 record at the time. On May 1, Hardy fouled a ball off of his foot and was later removed from the game. He later got x-rays on his foot and was placed on the 15-day DL.