Antonelli joined MoMA in February 1994 and is a curator in the Department of Architecture and Design there. Her first high-profile exhibition for MoMA, "Mutant Materials in Contemporary Design" (1995), was followed by "Thresholds: Contemporary Design from the Netherlands" (1996), "Achille Castiglioni: Design!" (1997–98), "Projects 66: Campana/Ingo Maurer" (1999), "Open Ends," and "Matter" (September 2000-February 2001). Her exhibition "Workspheres" (2/8-4/22/2001) was devoted to the design of the workplace of the near future. In 2005 she curated the exhibition entitled "Safe: Design Takes on Risk" for MoMA.