Merzenich was director and Chief Scientific Officer of Scientific Learning between November 1996 and January 2003. Merzenich took two sabbaticals from UCSF, in 1997 and 2004. In 1997 he led research teams at Scientific Learning Corporation, and in 2004 at Posit Science Corporation. Currently, Merzenich's second company, Posit Science Corporation, is working on a broad range of behavioral therapies. Their lead product is a brain-training application called BrainHQ (TM). Merzenich is Chief Scientific Officer, and on the Board of Directors, at Posit Science.