The aircraft were used in France for tactical night attacks on targets in German-occupied France and Belgium and for strategic bombing of industrial and transport targets in the Rhineland. Some aircraft were temporarily diverted to anti-submarine reconnaissance and bombing in the Tees estuary in 1917 and two aircraft operated in the eastern Mediterranean. The Type O made such an impression that for many years after the war any large aircraft in Britain was referred to as a "Handley Page", even getting a dictionary entry.