The .460 Weatherby is overly powerful for lion or leopard. Lion are thin skinned and weigh no more than while leopards weigh no more than . When the .460 Weatherby is used for hunting leopard or lion, a rapidly expanding bullet is normally used. Bullets ideal for lion or leopard begin with the bullets. A-Square's Lion Load, a fragmenting soft point is one such load appropriate for the big cats. Apart from the A-Square Lion Load bullets ranging in weight from are better used on lion and leopard. Since the .460 Weatherby can drive these bullets at over , and the large felidae are susceptible to hydrostatic shock, these lighter weight bullets in relation to the caliber may provide the best option if the .460 is chosen for the big cats. However, as no mainstream ammunition manufacturer loads these bullets, tailoring such loads for lion or leopard is strictly an option available only to the handloader or for those willing to have custom ammunition made to order.