After 13 years away from acting, Locke returned to the screen in 1999 with small roles in the straight-to-video films "The Prophet's Game" with Dennis Hopper and "Clean and Narrow" with Wings Hauser. In 2014, the media announced that Locke would serve as an executive producer on the Eli Roth film "Knock Knock", starring Keanu Reeves. She came out of retirement once more in 2016, shooting Alan Rudolph's indie "Ray Meets Helen" with Keith Carradine. The film was screened at Laemmle Music Hall on May 6, 2018, less than six months before Locke died.