In a game on August 20, 1957 against the Washington Senators, Doby helped preserve pitcher Bob Keegan's no-hitter with a backhand catch off a long line drive from Herb Plews, one of "two close calls" for Keegan that game. His 1957 home run total of 14 tied for the team-high, as he managed a .288 average and recorded 79 RBIs, second-highest on the team after former Indians teammate Minnie Miñoso. The White Sox finished second in the AL with a 90–64 record.