Arctic Monkeys performed this song on Jo Whiley's Live Lounge on BBC Radio 1 in their second appearance there, along with their single at the time, "Brianstorm". In summer 2007, "You Know I'm No Good" was used in advertisements and in the first season opening for AMC's TV drama "Mad Men", although it was replaced with the current theme song for DVD release. It was also used for the opening to ITV's "Secret Diary of a Call Girl". On the recap of The Best Songs of 2007 by "Entertainment Weekly" magazine, this song ranked at number two.