In 2016 "Day of the Dead", a Grateful Dead cover album, was released. Its proceeds would benefit the Red Hot Organization, an international charity dedicated to raising funds and awareness for HIV and AIDS, Hornsby performed on a track, "Black Muddy River", along with indie folk band (and Justin Vernon's former band) DeYarmond Edison. Hornsby performed the song alongside Vernon that same year in Eau Claire, Wisconsin. Hornsby performed alongside Vernon at Coachella in 2017, performing "I Can't Make You Love Me;" the performance also featured Jenny Lewis.