Two Clovis points found in the Salladasburg area in a "stream site" are the earliest evidence of human activity along Larrys Creek ("circa" 10,000 BCE). The earliest recorded inhabitants of the Susquehanna River valley were the Iroquoian speaking Susquehannocks. Their name meant "people of the muddy river" in Algonquian. Decimated by diseases and warfare, they had died out, moved away, or been assimilated into other tribes by the early 18th century. The lands of the West Branch Susquehanna River Valley were then chiefly occupied by the Munsee phratry of the Lenape (or Delaware), and were under the nominal control of the Five (later Six) Nations of the Iroquois. The Great Shamokin Path crossed the creek at a ford near its mouth; however, no trails of the indigenous peoples are recorded as having followed Larrys Creek north.