The following year, he received a $3,000 sign-on bonus from the Cincinnati Reds and pitched 31 games for the Reds, as a reliever. Lisenbee played his last game in major league baseball at the age of 47 on September 7, 1945, and was released by the Cincinnati Reds on September 11, 1945. He had the distinction of being the last player born in the 1800s to appear in a major league game. Following his release from the Reds, he returned to his hometown of Clarksville and continued to pitch for the Clarksville Colts of the Kitty Hawk League until he was fifty-one-years-old. He then sold the Clarksville Colts and retired from baseball.