Moss chaired the Consumer Subcommittee of the Senate Commerce Committee where he sponsored a measure, the Cigarette Labeling and Advertising Act of 1966, requiring detailed labeling on cigarette packages noting the health hazards of smoking and banning tobacco advertising on radio and television. He also sponsored the Consumer Product Warranty and Guarantee Act (known as the Magnuson-Moss Act), the Toy Safety Act, the Product Safety Act, and the Poison Prevention Packaging Act. He was also Chairman of the U.S. Senate Committee on Aeronautical and Space Sciences from 1973 to 1977.