Chloroquine is an antimalarial and antiamebic drug. It is also used in the management of rheumatoid arthritis and lupus erythematosus. Pyrithione is used as an anti-dandruff agent in medicated shampoos for seborrheic dermatitis. It also serves as an anti-fouling agent in paints to cover and protect surfaces against mildew and algae. Clioquinol and PBT2 are 8-hydroxyquinoline derivatives. Clioquinol has antiprotozoal and topical antifungal properties, however its use as an antiprotozoal agent has widely restricted because of neurotoxic concerns. Clioquinol and PBT2 are currently being studied for neurodegenerative diseases, such as Alzheimer's disease, Huntington's disease and Parkinson's disease. Gramicidin is used in throat lozenges and has been used to treat infected wounds. Epigallocatechin gallate is used in many dietary supplements and has shown slight cholesterol-lowering effects. Quercetin has a bitter flavor and is used as a food additive and in dietary supplements. Hinokitiol (ß-thujaplicin) is used in commercial products for skin, hair and oral care, insect repellents and deodorants. It is also used as a food additive, shelf-life extending agent in food packaging, and wood preservative in timber treatment.