Recent Georgetown University graduates Alec (Judd Nelson), his girlfriend, Leslie (Ally Sheedy), Kevin (Andrew McCarthy), Jules (Demi Moore), and Kirby (Emilio Estevez) are waiting to hear about the conditions of their friends, Wendy (Mare Winningham), a sweet-natured girl devoted to helping others, and Billy (Rob Lowe), a former fraternity boy and now reluctant husband and father, after a minor car accident caused by Billy's drinking. At the hospital, Kirby spots a medical student named Dale (Andie MacDowell), with whom he has been infatuated since college.