The region city of Prague is an important centre of research. It is the seat of 39 out of 54 institutes of the Czech Academy of Sciences, including the largest ones, the Institute of Physics, the Institute of Microbiology and the Institute of Organic Chemistry and Biochemistry. It is also a seat of 10 public research institutes, four business incubators and large hospitals performing research and development activities such as the Motol University Hospital or Institute for Clinical and Experimental Medicine, which was the largest transplant center in Europe as of 2019. Universities seated in Prague (see section "Colleges and Universities") also represent important centres of science and research activities.