Warren was initially inhabited by Native Americans of the Seneca nation. French explorers had longstanding claims to the area which they acted to secure in an unambiguous fashion with a military-Amerindian expedition in 1749 that buried a succession of plaques claiming the territory as France's in response to the formation of the colonial Ohio Companyand the first of these was buried in Warren but ultimately control was transferred to the British after the French and Indian War. After the Revolutionary War, General William Irvine and Andrew Ellicott were sent to the area to lay out a town in 1795. It was named after Major General Joseph Warren.