During the "Inhumans vs. X-Men" storyline, Beast overhears Medusa telling the rest of the Inhuman Royal Family that they to be prepared just in case the X-Men lose patience in their truce and attack them. As the X-Men take action against the Inhumans, Medusa sends Iso and Inferno to find out what happened to Black Bolt and Crystal as she prepares for battle. Medusa then fights the time-displaced Beast in the lab of the original Beast as she effectively calls off the truce. As she gets the upper hand, Nightcrawler teleports in and takes her away. Despite the subsequent escalation of the conflict, when Medusa learns that the X-Men only attacked now because the Terrigenesis cloud was about to reach the point where it would make the whole planet toxic to mutants, she resolves the situation by destroying the cloud, preventing any further Inhumans from manifesting their powers, feeling that the future of her species is not worth the present loss of mutant life that would result. She also abdicates her throne to Iso.