Florence's son Marshall died on January 1, 1915, of tuberculosis. She made a trip to Colorado later in the year to pay his debts and ended up becoming friends with some of his associates and wife Esther. Along with her husband, she travelled to California and Hawaii before settling into life in Washington, D.C. as the wife of a senator. After returning from Marion, Florence decided to rent a house in the Kalorama neighborhood of D.C. In January 1916, Florence suffered from heart palpitations, and she called Dr. Sawyer to help with her mental health. To cope with a growing depression, she helped furnish the new house and hired staff for assistance. Florence helped her husband with his correspondence and invited press attention. Despite her stand on suffrage, she could not persuade Warren in 1916 to make up his mind, as he preferred partisan leadership.