The first single from "Dream Days at the Hotel Existence" was "Lost and Running" and the video clip, which was directed by Damon Escott and Stephen Lance of Head Pictures, began showing in Australia on 21 April 2007. The single made its Australian radio debut on 16 April 2007, but had been available for several days beforehand on the Powderfinger's MySpace web page. An exclusive early release of the song was played by Triple J on 13 April 2007. "Lost and Running" reached number five on the ARIA singles chart.