In 2010, the Cowboys drafted future Pro Bowler Dez Bryant in the first round, but Williams retained his starting role alongside Austin. He got off to a quick start with 21 receptions for 306 yards and 5 touchdowns in the first 5 games, but his production declined significantly in his final 10 games (16 catches for 224 yards and no touchdowns) as Bryant gained a bigger role in the offense. His best game with the Cowboys was against in state rival Houston Texans, in which he recorded 117 receiving yards and two touchdowns on five catches while only being targeted six times.