Breslin played on-screen siblings with his real-life younger sister Abigail Breslin in the 2004 comedy-drama "Raising Helen", starring Kate Hudson as their aunt and guardian. The two siblings worked together again in the 2004 romantic comedy "", in which Spencer at the age of 12 played a prince and Abigail made a cameo as a girl at an orphanage. The movie had a worldwide box office of $122 million. In 2004, Spencer Breslin was a regular as a dim-witted 12-year-old on the short-lived CBS sitcom "Center of the Universe" starring John Goodman. He also appeared in the "Wonderfalls" episode "Lovesick Ass" in 2004. In 2004, Breslin also was asked to read alongside Alyson Stoner, Dylan and Cole Sprouse, and Hailey Anne Nelson when Dr. Seuss won his Star on the Hollywood Walk of Fame.