T.O Entertainment adapted "Shinkyoku Sōkai Polyphonica" into a twelve episode anime series directed by Junichi Watanabe and Masami Shimoda and written by Ichiro Sakaki. On February 6, 2007, one month after the first manga adaptation was announced, the anime adaptation was announced. Broadcast on TBS, the series premiered on April 3, 2007 and aired weekly until its conclusion on June 19, 2007. The music was composed by Hikaru Nanase. Two pieces of theme music were used for the anime. "Apocrypha" is performed by eufonius as the opening theme. is performed by kukui as the ending theme.