The route heads northwest as an undivided road from Nesquehoning through mountainous areas, passing through Beaver Meadows. The road reaches the city of Hazleton, where it passes through developed areas and crosses PA 309. PA 93 continues through West Hazleton and becomes a divided highway before it reaches an interchange with Interstate 81 (I-81). The road becomes undivided again and passes through Conyngham before coming to an interchange with I-80. PA 93 continues northwest and passes through Nescopeck before crossing the Susquehanna River into Berwick and forming a concurrency with US 11. The route continues west from Berwick through rural areas to Orangeville.