LA 19 has three notable junctions, two of which provide access to downtown Baton Rouge. These are US 61 and Interstate 110 (I-110) and are located within the first of the route on its southern end. The highway also intersects LA 10, an east–west cross-state route that connects with Jackson and Clinton, two nearby small towns of historic character. The latter is also the seat of East Feliciana Parish. The remaining junctions along LA 19 mostly serve to connect the route with the parallel US 61 and LA 67.