In 2004, Comedy Central featured Gottfried's stand-up material for "Shorties Watchin' Shorties". Gottfried was part of an online advertising campaign for Microsoft's Office XP software, showing, in a series of Flash-animated cartoons, that the Clippy office assistant would be removed. In 2006, Gottfried topped the "Boston Phoenix"'s tongue-in-cheek list of the world's 100 Unsexiest Men. In April 2006, Gottfried performed with the University of Pennsylvania's Mask and Wig Club in their annual Intercollegiate Comedy Festival. Also in 2006, he made an appearance on the "Let's Make a Deal" portion of "Gameshow Marathon" (as a baby in a large high chair, he says "Hey Ricki, I think I need my diaper changed!"), and in the Dodge Viper in the big deal (where he tells the contestants "What were you thinking?!" because neither one picked it). He also guest-starred in "The Grim Adventures of Billy and Mandy" as Santa Claus in the one-hour Christmas Special. He voiced Rick Platypus in an episode of "My Gym Partner's a Monkey" entitled "That Darn Platypus".