On 1 November 1755, the Lisbon earthquake partially destroyed the Church, resulting in the destruction of part of the vaulted-ceiling and a belfry over the lateral doorway. A fire, which was triggered after the event, consumed the orphanage, except the chapel of the Holy Sacrament (the former Chapel of D. Simôa), and altarpiece of the Chapel of the Holy Christ of Padecentes. The church of Conceição dos Freiras was also ruined, making its reconstruction non-viable owing to the new city plan.