The story of Dyesebel begins when an amnesiac mermaid-turned-human named Lucia (Jean Garcia) fell in love with a human. They got married and had a beautiful baby, but instead of human baby she delivered a mermaid. The child is called Dyesebel (Marian Rivera). Although surprised by their daughter's strange form, Lucia and her husband Tino (Wendell Ramos) promise to love their child no matter what. In no time at all, their neighbors discovered the couple's secret. When the community is hit with a series of catastrophes, the town believes that the anomaly is caused by Dyesebel; an accusation that leads to Tino's death and Lucia to offer her only daughter to the sea, where she would belong. Unknown to Lucia is that in the heart of the sea, Dyesebel's adventures and misfortunes will begin. It is within the confines of the waters that Dyesebel will lead a new life — a journey that will take her to the depths of the sea, as well as to chaos of the city. Dyesebel discovers that she can also be a human being by visiting Amafura (Rufa Mae Quinto) to get a secret necklace that makes her a human; but a price must be made, for her to sacrifice her true possession, to gain something special.