McDuffie was hired to help revamp and story-edit Cartoon Network's popular animated "Ben 10" franchise with ', continuing the adventures of the ten-year-old title character into his mid and late teenage years. During the run of the series, McDuffie wrote episodes 1–3, 14, 25–28, 45 and 46 and/or story-edited all forty-six episodes. McDuffie also produced and story edited for the second sequel series ', which premiered April 23. 2010. He wrote episodes 1, 10, 11, 16, 30, 39 together with J. M. DeMatteis and 52.