On November 28, 2016, Lowry set a franchise record by hitting all six of his three-pointers for a game-high 24 points in a 122–95 win over the Philadelphia 76ers. On December 9, he scored 21 of his then season-high 34 points in the second half of the Raptors' 101–94 win over the Boston Celtics. He set a new season high on December 23, scoring 36 points, including 19 in the fourth quarter, to lead the Raptors to a 104–98 victory over the Utah Jazz. On January 1, 2017, he scored 20 of his season-high 41 points in the fourth quarter of the Raptors' 123–114 win over the Los Angeles Lakers. He also had 9 rebounds, and 7 assists, and went 5-of-6 from three-point range. On February 5, 2017, he recorded his ninth career triple-double with 15 points, 11 rebounds, and 11 assists in a 103–95 win over the Brooklyn Nets. The following day in the Raptors' 118–109 win over the Los Angeles Clippers, Lowry became the Raptors' franchise leader in three-pointers when he buried one from beyond the arc with 5:27 to play in the first half. His third three-pointer of the night gave him 802 in a Toronto uniform, surpassing Morris Peterson's mark. On April 5, 2017, he returned from an 18-game absence with a wrist injury, played 42 minutes, and had 27 points and 10 assists to help the Raptors overcome a 20-point first-half deficit in a 105–102 victory over the Detroit Pistons.