The pharmacologically active ingredient contained in bear bile is ursodeoxycholic acid (UDCA). This can be synthesized using cow or pig bile, or even using no animal ingredients. The generic drug name is Ursodiol and it is now being widely produced under brand names such as Actigall, Urso, Ursofalk, Ursogal and Ursotan. It was estimated in 2008 that 100,000 kg of synthetic UDCA was already being used each year in China, Japan and South Korea, and that the total world consumption may be double this figure. However, many traditional doctors still consider natural (but farmed) UDCA a superior product.