However, the main active compound lapachol has since turned out to be toxic enough to kill fetuses in pregnant rats and reduce the weight of the seminal vesicle in male rats in doses of 100 mg/kg of body weight. Still, lapachol has strong antibiotic and disinfectant properties, and may be better suited for topical applications. Lapachol induces genetic damage, specifically clastogenic effects, in rats. Beta-lapachone has a direct cytotoxic effect and the loss of telomerase activity in leukemia cells "in vitro".