US 250 continues southeast as Churchville Avenue, which crosses the Middle River on its way to the independent city of Staunton. The highway meets SR 262 (Woodrow Wilson Parkway) at a diamond interchange at the west city limits and heads southeast toward the downtown area. At the north end of downtown, US 250 turns onto Augusta Street, where the highway runs concurrently with US 11 Business. The highways pass to the west of Mary Baldwin College and the Woodrow Wilson Presidential Library and intersect SRs 252 and 254, which both follow Frederick Street westbound and Beverley Street eastbound. At the south end of downtown, just north of the Staunton Amtrak station, US 250 and US 11 Business turn east onto Johnson Street, which parallels CSX's North Mountain Subdivision. US 11 Business's southern terminus is at US 250's intersection with US 11 and SR 254. SR 254 heads north on Coalter Street and east with northbound US 11 on Commerce Road while US 250 and US 11 pass under the railroad together on Greenville Avenue. South of the rail crossing, US 250 turns east onto Richmond Avenue.