Born on the 26nd of April, 1936 to Oscar and Maria Calamatta, he was brought up during the post-war Maltese environment. Serracino-Inglott studied at the then Royal University of Malta (BA 1951-1955), Campion Hall, Oxford as a Rhodes Scholar (MA 1955-1958), the Institut Catholique de Paris (BD "cum laude" 1958-1960) and the Università Cattolica del Sacro Cuore (Ph.D. 1960-1963) with a thesis on Wittgenstein’s "Tractatus Logico-Philosophicus". His start at the University of Malta was as a librarian in 1963 and just two years later he started teaching philosophy there. In 1971 he became an established professor at the University of Malta and served as chairperson of the University's chair of philosophy, a post he would retain for seven years until then Prime Minister of Malta, Dom Mintoff, suspended the chair. He would return as chairperson in 1987 when the post was resumed and would consecutively retain the post until 1996. Serracino Inglott was professor of aesthetics at the 'Instituto Internazionale di Arte e Liturgia' at Milan, visiting professor at Panthéon-Assas University (1989–1990), UNESCO Fellow at the Open University, UK (1978) and guest lecturer at the universities of Cincinnati, Milan (Cattolica), Venice (Ca Foscari), Palermo and the College of Europe at Bruges (1989, 1990).