Republic Polytechnic's project team began operating in the premises of Data Storage Institute, National University of Singapore in January 2002. On 1 July that year, it moved into Tanglin Campus which was previously occupied by the Ministry of Education, Singapore. The polytechnic opened its doors to the first intake of students in 2003 before moving to the current Woodlands campus at Woodlands Avenue 9 in 2007. The polytechnic saw its twelfth batch of students graduating in 2017, also the fifteenth anniversary of the polytechnic.