On November 3, 2014, Lopez made his 2014–15 season debut after missing the first two games with a foot injury. In just under 24 minutes of action, he recorded 18 points, 6 rebounds, 2 blocks and 1 steal in the 116-85 win over the Oklahoma City Thunder. He went on to miss eight games between December 8 and 21 with a lower back strain, and following his return on December 23 against Denver, Lopez was benched in favor of Mason Plumlee who was the starting center in Lopez' absence. He remained coming off the bench for three more games before starting alongside Plumlee on December 30 against Chicago with Kevin Garnett out resting. He subsequently recorded 29 points, 5 rebounds and 2 blocks in the 96-82 win.