Medusa first appeared in "Fantastic Four" #36 (1965), and was created by Stan Lee and Jack Kirby. She appears first in flashback, then in costume as part of the fledgling "Frightful Four". She appears in #38, 41, 42, 43, 44-48 and in various subplot glimpses from #49-62. The Inhumans also appear in "Fantastic Four" # 82-83, with Medusa. They are granted their first new adventure in "Fantastic Four Annual" #5, and a solo series in the split-book "Amazing Adventures" (volume 2) #1-10. The first four installments are written and drawn by Jack Kirby. The second four installments are written by Roy Thomas and illustrated by Neal Adams. That storyline flows into the ongoing "Kree-Skrull War" in the "Avengers" title #94-97.