Anita was born in Memphis, Tennessee. In 1947, she married Al Kerr, and they moved to Nashville the following year so that he could take a job as a dee-jay on WKDA. The performances of a vocal quintet she organized attracted the attention of a WSM radio program director, who then hired her to lead and arrange an octet choir on the radio station's "Sunday Down South" broadcasts. Joining her were singers Carl Garvin, Jim Hall, Doug Kirkham, Mary Ellen Puckett, Evelyn Wilson, Mildred Kirkham, and Don Fotrell. The group's first recording session was with Red Foley, and their collaboration resulted in a No. 16 hit on Billboard's Pop chart in 1950: "Our Lady of Fatima." The following year, producer Owen Bradley signed them to record for Decca Records. Their talents in demand, Anita's group continued to sing backup for other country artists in Nashville, including Eddy Arnold, Burl Ives, and Ernest Tubb. The group's recording sessions—initially averaging two per week—increased to eight sessions weekly by 1955.