In 1495 he signed and dated a "Deposition" for the Florentine convent of Santa Chiara (Palazzo Pitti). Towards 1496 he frescoed a Crucifixion, commissioned in 1493 for Maria Maddalena de' Pazzi, Florence (the "Pazzi Crucifixion"). The attribution to him of the picture of the marriage of Joseph and the Virgin Mary (the "Sposalizio") now in the museum of Caen, which indisputably served as the original, to a great extent, of the still more famous "Sposalizio" painted by Raphael in 1504 (Brera, Milan), is now questioned, and it is assigned to Lo Spagna. A vastly finer work of Perugino's was the polyptych of the "Ascension of Christ" painted ca 1496–98 for the church of S. Pietro of Perugia, (Municipal Museum, Lyon); the other portions of the same altarpiece are dispersed in other galleries.