After extensive renovations undergone by real-estate company 601W, the building opened to office tenants in October 2019. In August 2019, Uber signed a 10-year lease to become the building's largest tenant, occupying . Construction on the space to be utilized by Uber will begin in the spring of 2020. The structure will also include new Chicago offices for Walgreens, occupying and housing 1,800 employees. PepsiCo will relocate its Chicago office of 1,300 employees and occupy , while the Ferrara Candy Company announced that it would relocate its headquarters to the Post Office building in 2019, occupying and bringing nearly 400 jobs. The Federal Home Loan Bank of Chicago will also be a tenant.