During the "Death of the Inhumans" storyline, Medusa is seen with the Inhuman Royal Family when they find the dead bodies of the Universal Inhumans. When an explosive trap starts to go off, Medusa managed to make it out alive. Medusa and the Inhuman Royal Family later mourn the fallen Inhumans following Vox's attack on New Arctilan. After Black Bolt was taken captive by the Kree, Medusa and the surviving Inhuman Royal Family members try to recruit Beta Ray Bill in their fight against Vox and the Kree. The Inhuman Royal Family are finally taking the battle to the Kree and arrive just in time to save Black Bolt from Vox. Medusa is present when it is discovered that Vox is not a Super-Inhuman and is just a Kree programming. When the Inhuman Royal Family and Beta Ray Bill take the battle to the Kree, Medusa and Karnak fight a Vox-controlled Crystal and Lockjaw. After Black Bolt's sonic scream is used on the Vox-controlled Inhumans enough to free Crystal and Lockjaw and cause the Kree to retreat, Medusa is pleased that Crystal and Lockjaw are freed from Vox's control. Black Bolt emerges from the room as Medusa orders Lockjaw to take them away from the Kree base. When Crystal asks where they should go, Black Bolt uses his sign language to say "home." Lockjaw then teleports them away.