Near Farmington, I-96/US 16 continued to the southeast of the present-day I-96/I-275/I-696/M-5 interchange along the current M-5 freeway. Grand River Avenue through there was Business Loop I-96 (BL I-96). The freeway ends at a junction with Grand River Avenue that also marked the end of the business loop and the eastern end of I-96 at the time. From there, US 16 continued along Grand River Avenue the rest of way into Downtown Detroit. Along that routing, it intersected US 24 at Telegraph Road and M-39 at Southfield Road. US 12 joined US 16 along Grand River Avenue at Plymouth Road. The two ran the rest of the way concurrently to Cadillac Square. There they terminated at a common point with US 10 (Woodward Avenue) and US 112 (Michigan Avenue). US 25 ran through the square on Fort Street and Gratiot Avenue.