The villain has his third eye surgically removed, making him lose his hypnotic powers. Eventually it grows back, he fakes his death in an explosion at a lab and in revenge ages half of the Justice League and banishes the remainder to three other worlds, where he has caused reptile, insect, and marine life to become intelligent, planning to conquer the worlds later. When Despero attempts to deceive Wonder Woman by disguising himself as an aged Superman, she overpowers the villain with her Lasso of Truth, realizing the energy should not have affected Superman, and forces him to undo his actions. Despero is thwarted again when the Justice League intervene in his intergalactic plans of conquest, save member the Martian Manhunter who is being forced to play in a life and death chess match.