After leaving the PGA Tour, Locke continued his career in Europe and Africa, where he felt more comfortable. He won 23 times in Europe, most notably a quartet of successes in The Open Championship, which came in 1949, 1950, 1952 and 1957. He was the first of many South Africans who subsequently won major championships, including Gary Player, Ernie Els, Retief Goosen, Trevor Immelman, Louis Oosthuizen and Charl Schwartzel. His win in the 1957 Open Championship was with some controversy. Locke had failed to properly replace his ball after marking on the 72nd green, and proceeded to putt out. This had been confirmed through newsreel footage provided to the Royal and Ancient after the trophy presentation. The rules at the time made no provision for a two shot penalty, thus Locke's win could have been overturned through disqualification. However, the Championship committee did not enforce the disqualification rule, citing "equity and spirit of the game" as overriding factors in sustaining the posted result.