Stubblefield was named a First Team All-Big Ten selection his senior year (2004), in which he caught 89 passes with 1,095 yards receiving and scored 16 touchdowns, third-most in the nation. He became the first player to lead the conference in receptions two seasons in a row since Ohio State's David Boston in 1998. The All-American participated in the East-West Shrine All-Star Game, where he had seven receptions for 128 yards and scored two touchdowns, while throwing a pass that led to the first touchdown. He became the first consensus All-American receiver for Purdue since Bernie Flowers in 1952 and earned First Team-All Big Ten honors.