With the guidance of Captain Blue, Joe fights his way through a number of Movieland's locations such as cities, caves, an underwater base, and a submarine, often travelling via his trusty, robot aircraft "Six Machine". One by one, Joe defeats the members of the Jadow, the game's bosses. These include Dark Fiend Charles the 3rd, Iron Ogre Hulk Davidson, Aquatic Terror Gran Bruce, a doppelgänger of Viewtiful Joe, and Blade Master Alastor. Before fighting Alastor, he reveals that in order for the Jadow to break out of Movieland and into the land of humans, they need the "DNA of the Creator", namely Silvia. Joe makes his way to her, trumping the Jadow's leader Inferno Lord Fire Leo in combat, only to witness Silvia being kidnapped once again afterwards. Joe and Six Machine race off into outer space after her in the game's final episode.