Perugino's last frescoes were painted in the church of the Madonna delle Lacrime in Trevi (1521, signed and dated), the monastery of Sant'Agnese in Perugia, and in 1522 for the church of Castello di Fortignano. Both series have disappeared from their places, the second being now in the Victoria and Albert Museum. He was still at Fontignano in 1523 when he died of the plague. Like other plague victims, he was hastily buried in an unconsecrated field, the precise spot now unknown.