Lowndes made her acting debut on the 2005 television film "Saving Milly" as Andrea Kondracke at the age of 16. This was followed by a guest role on an episode of "Masters of Horror", she was later cast as Becky, a recurring role in the sitcom "Alice, I Think". She also made a guest appearance on "Kyle XY". Her next film role was a supporting role in the Lifetime movie "To Have and to Hold" released in 2005, followed by a pilot called "Pretty/Handsome" in 2007—which did not get picked up.