In his final season with the Packers, Holliday missed four games with a torn pectoral muscle and two with a knee injury. In the 10 games he did play, Holliday accumulated 26 tackles, six sacks, an interception, three forced fumbles and four passes defensed. His second career interception came in a December 15 contest against then San Francisco 49ers quarterback Jeff Garcia. Holliday posted the best game of his career on December 22 against the Buffalo Bills, in which he sacked Bills quarterback Drew Bledsoe five times and forced three fumbles - a Packers single game record. The performance against the Bills earned him NFC Defensive Player of the Week honors.