Most dicentric chromosomes are known to form through chromosomal inversions, which are rotations in regions of a chromosome due to chromosomal breakages or intra-chromosomal recombinations. Inversions that exclude the centromere are known as paracentric inversions, which result in unbalanced gametes after meiosis. During prophase of meiosis I, homologous chromosomes form an inversion loop and crossover occurs. If a paracentric inversion has occurred, one of the products will be acentric, while the other product will be dicentric. The dicentric chromatid is pulled apart during anaphase of meiosis I with such force that the chromosome breaks at random positions. These broken fragments result in deletions of genes that lead to genetically unbalanced gametes. This can have severe consequences, contributing to the development of genetic disorders such as Kabuki syndrome and Edwards syndrome.