O'Grady had regular roles on the short-lived CW series "Hidden Palms" as Karen Hardy in 2007, and on "Hellcats", playing Wanda Perkins, the mother of the main character, from 2010 to 2011. In 2008, she had a recurring role on the ABC series "Desperate Housewives" as Anne Schilling, a woman who is having an affair with the character Porter Scavo (at that point a teenager). She has made appearances on "Monk", ', "The Mentalist", ', "Drop Dead Diva", "Hawaii Five-0", and "Castle". She also was cast in a major recurring role as Conrad's first wife on ABC primetime soap opera "Revenge", opposite Madeleine Stowe.