Numerous boroughs and villages are situated in the watershed of Wiconisco Creek. Boroughs in the western part of the watershed include Berrysburg, Elizabethville, and Millersburg. Boroughs in the central part of the watershed include Lykens, Gratz, and Wiconisco and boroughs in the watershed's eastern portion include Tower City and Williamstown. Villages in the eastern part of the watershed include Muir, Orwin, Reinerton, and Sheridan. Villages in the central part of the watershed include Big Run, Dayton, and Loyalton and villages in the watershed's western section include Cloverly Acres, Pleasant Hills, and Reservoir Heights.