In 2016, Vodianova was selected and photographed by Annie Leibovitz as part of the 43rd Pirelli Calendar, which celebrated some of the world's most inspiring women, such as Tavi Gevinson, Serena Williams, Amy Schumer, Yoko Ono, Fran Lebowitz, Patti Smith, Kathleen Kennedy, Yao Chen, Mellody Hobson, Ava DuVernay, Agnes Gund, and Shirin Neshat. This was her fifth appearance in Pirelli. She also fronted Riccardo Tisci's Givenchy 2016 Spring/Summer campaign along with Tisci's longtime muse Mariacarla Boscono. Other veteran models in the campaign included Lara Stone, Joan Smalls, Miranda Kerr, Gemma Ward, Iselin Steiro, Candice Swanepoel. This was Vodianova's fourth appearance in Tisci's Givenchy campaigns. Shot by Steven Meisel, she became the campaign model for Prada's spring/summer 2016 collection along with their comeback muse Sasha Pivovarova and Dutch newcomer Yasmin Wijnaldum. Vodianova appeared in her ninth ad campaign for Stella McCartney in their spring/summer 2016 collection together with Boscono. She also returned as the campaign model for Italian denim wear brand Miss Sixty. In October 2016, she appeared in her second campaign ad for David Yurman, which was shot by Bruce Weber for the fall/winter 2016 campaign.