Meyrowitz joined TJX Companies in 1983. In 2001, she became Executive Vice President of the company, as well as the President of Marmaxx, the largest division of the company. She rose to Senior Executive Vice President in March 2004, which she maintained until January 2005. In January 2005, she left her positions and became an advisor for TJX and Berkshire Partners. Her plan was to leave the advisory role in September of that year to "pursue new opportunities and challenges" outside of TJX.