In film and on television, Mantegna is best known for his roles in box office hits such as "Three Amigos" (1986), "The Godfather Part III" (1990), "Forget Paris" (1995), and "Up Close and Personal" (1996). He starred in the television series "First Monday" (2002) and "Joan of Arcadia" (2003–2005). He has earned Emmy Award nominations for his roles in three different miniseries: "The Last Don" (1997), "The Rat Pack" (1998), and "The Starter Wife" (2007). He has also served as executive producer for various movies and television movies, including "Corduroy" (1984), "Hoods" (1998), and "Lakeboat" (2000), which he also directed. Additionally, he played Robert B. Parker's fictional detective Spenser in three made-for-TV movies between 1999 and 2001, and has narrated a number of audiobook readings of the Spenser novels. From 2007 to 2020, he starred in the CBS television series "Criminal Minds" as FBI Supervisory Special Agent David Rossi. Beginning with the 1991 episode "Bart the Murderer", Mantegna has voiced the recurring role of mob boss Fat Tony on the animated series "The Simpsons", as well as "The Simpsons Movie" (2007).