The Delaware Valley Regional High School Terriers compete in the Skyland Conference, which is comprised of public and private high schools in Hunterdon, Somerset and Warren counties, and operates under the supervision of the New Jersey State Interscholastic Athletic Association (NJSIAA). With 509 students in grades 10-12, the school was classified by the NJSIAA for the 2019–20 school year as Group II for most athletic competition purposes, which included schools with an enrollment of 486 to 758 students in that grade range. The school was classified by the NJSIAA as Group II South for football for 2018–2020.