"S. pyogenes" is the cause of many human diseases, ranging from mild superficial skin infections to life-threatening systemic diseases. Infections typically begin in the throat or skin. The most striking sign is a strawberry-like rash. Examples of mild "S. pyogenes" infections include pharyngitis (strep throat) and localized skin infection (impetigo). Erysipelas and cellulitis are characterized by multiplication and lateral spread of "S. pyogenes" in deep layers of the skin. "S. pyogenes" invasion and multiplication in the fascia can lead to necrotizing fasciitis, a life-threatening condition which requires prompt surgical intervention to reduce morbidity and mortality. The bacterium is found in neonatal infections.