Turley made his MLB debut with the St. Louis Browns in 1951, and stayed with the team through their first season in Baltimore, when he appeared in his first MLB All-Star Game. After the 1954 season, he was traded to the New York Yankees. With the Yankees, Turley appeared in two more All-Star Games. He led the American League in wins in 1958, and won the Cy Young Award, World Series Most Valuable Player Award, and Hickok Belt that year. He finished his playing career with the Los Angeles Angels and Boston Red Sox in 1963, and then coached the Red Sox in 1964.