Despero first appears when in pursuit of two rebels from the planet Kalanor, which he rules as a tyrant (in Pre-"Crisis" it is an other-dimensional solar system). They are attempting to create a weapon to defeat him. The rebels make contact with the Justice League of America with JLA member Flash accepting Despero's challenge after he places the rest of the group in a hypnotic trance, but the Flash is defeated in a game similar to chess due to Despero cheating using his third eye's mental powers, and along with the rest of the JLA sent to different worlds. Despero found out about this by reading the mind of one of the rebels he had tracked down and teleported, though her father and Flash were protected by the dimensional traveller's 'blue glow'. However, the JLA are able to escape all the dangers on the worlds and return to Earth using a dimensional traveler one of Despero's henchmen possesses after the Flash defeats him. Despero has found the rebel and plans to use the energy-absorbing weapon they hoped to use to disable his weapons to conquer Earth, but Snapper Carr uses it to weaken the villain after pretending he has been hypnotized, though the 'blue glow' protected him. Despero is then imprisoned and Kalanor is freed.