Fitzgerald's first solid outing came against the Washington Redskins in Week 2, where he had seven receptions for 133 yards and a touchdown in a 22–21 loss. Two games later, he had eight receptions for 102 yards in a 31–27 loss to the New York Giants. On November 13, in Week 10, he had seven receptions for 146 yards and two touchdowns in a 21–17 victory over the Philadelphia Eagles. His efforts against the Eagles garnered him NFC Offensive Player of the Week honors. A few games later, he had seven receptions for 149 yards and a touchdown against the San Francisco 49ers in a 21–19 victory in Week 14. On Christmas Eve, he had six receptions for 105 yards and a touchdown against the Cincinnati Bengals in a 23–16 loss in Week 16. He closed out the regular season with nine receptions for 149 yards against the Seattle Seahawks in a 23–20 victory. The Cardinals finished with an 8–8 record and missed the playoffs.