In 2000, Handler portrayed Larry Fine in the made-for-TV biopic "The Three Stooges". He played Goldman Sachs CEO Lloyd Blankfein in the HBO movie, "Too Big to Fail". The movie was based on the book of the same name written by Andrew Ross Sorkin. Handler has been most recently seen on "Californication" where he plays Charlie Runkle, the best friend and agent to David Duchovny's character, Hank Moody. In 2016 he had a recurring role in "" as Alan Dershowitz, an appellate adviser for the defense in the O. J. Simpson murder case in 1995.