On January 18, 2016, Lowry tied his career-high of made three-pointers in game with seven, scoring a game-high 31 points in total, in a 112–100 win over the Brooklyn Nets. On January 21, he was named as a starter to the Eastern Conference All-Star team for the 2016 NBA All-Star Game. He was also later named a contestant in the Three-Point Contest, making him the third Raptors player to participate in this event. On February 1, in a 112–93 loss to the Denver Nuggets, Lowry passed Alvin Williams for second all-time on the Raptors' assists list. The following day, Lowry and teammate DeMar DeRozan were selected as co-winners for Eastern Conference Player of the Month for January. The pair helped the Raptors go 12–2 during the month and record a franchise-record 11-game win streak. On February 14, Lowry finished his second All-Star game, held in Toronto for the first time, with 14 points, 10 assists, 5 rebounds, and 2 steals in the East's 196–173 loss to the West. On February 22, he recorded his eighth career triple-double (sixth as a Raptor) with 22 points, 11 assists and 11 rebounds in a 122–95 win over the New York Knicks. Four days later, he scored a career-high 43 points, on 15-of-20 shooting, and had nine assists, five rebounds, and four steals in a 99–97 win over the Cleveland Cavaliers. On February 29, he was named Eastern Conference Player of the Week for games played from February 22–28. On March 21, he was again named Eastern Conference Player of the Week, for games played from March 14–20, becoming the first Raptors player since Chris Bosh in 2009–10 to win the award multiple times in the same season. On March 30, he recorded 17 points, 11 assists, and six rebounds in a 105–97 win over the Atlanta Hawks, helping the Raptors reach 50 wins for the first time in franchise history. The team finished the regular season with a 56–26 record, good for first in the Atlantic Division for the third consecutive year, and second in the Eastern Conference.