The Curzons had three daughters but no son, as much as Lord Curzon wished for one. Lady Curzon's demanding social responsibilities, the tropical climate, a prolonged near-fatal infection following a miscarriage, and fertility-related surgery eroded her health. Despite several trips to England to convalesce, her health continued to decline. Following their return to England after Curzon's resignation in August 1905, her health was rapidly failing. She died on 18 July 1906 at home at 1 Carlton House Terrace, Westminster, London, at age thirty-six.