In a season-opening loss at the Cleveland Cavaliers, Lopez scored 21 points and grabbed 5 rebounds. On November 15, 2013, Lopez logged 27 points and 7 rebounds in an overtime win over the Phoenix Suns. On December 7, 2013, Lopez had 32 points and 7 rebounds against the Milwaukee Bucks. On December 20, 2013, the Nets announced Lopez was out for the remainder of the season with a foot injury he had suffered the night before against the Philadelphia 76ers. In the 17 games that Lopez played, he averaged 20.7 points 6 rebounds 56.3% from the field and 81.7% from the free throw line. This was the first season he didn't manage to record at least one double-double.