After his formal education ended, Soyer became associated with the Fourteenth Street School of painters that included Reginald Marsh, Isabel Bishop, Kenneth Hayes Miller, Peggy Bacon and, his teacher, Guy Pene du Bois. Soyer persistently investigated a number of themes—female nudes, portraits of friends and family, New York and, especially, its people—in his paintings, drawings, watercolors and prints. He also painted a vast number of self-portraits throughout his career. Soyer was adamant in his belief in representational art and strongly opposed the dominant force of abstract art during the late 1940s and early 1950s.