In 2000, Lopes became a featured rapper on several singles, including Spice Girl Melanie C's "Never Be the Same Again", which topped the charts in 35 countries, including the United Kingdom. She was also featured on "U Know What's Up", the first single from Donell Jones' second album, "Where I Wanna Be", and she rapped a verse in "Space Cowboy" with NSYNC on their 2000 album, "No Strings Attached". On October 4, 2000, Lopes co-hosted the UK's MOBO Awards with Trevor Nelson, where she also performed "U Know What's Up" with Jones. She also collaborated on "Gimme Some" by Toni Braxton for her 2000 album "The Heat". She had previously featured on Keith Sweat's song "How Do You Like It?". In 2001, she appeared in a commercial for the fashion brand Gap. In July 2001, Lopes appeared on the singers' edition of "Who Wants to Be a Millionaire" along with Joey McIntyre, Tyrese, Nick Lachey, and Lee Ann Womack. She dropped the $125,000 question and won $32,000 for her charity. After her death in 2002, the episode she appeared in was shown and was dedicated to her.