Although born in Chicago, Illinois, Cooper-Dyke grew up in South Central Los Angeles, California. Cooper-Dyke is the daughter of Mary and Kenny Cooper. Her father left the family when she was only six years old, leaving her mother to raise eight children. Cooper-Dyke attended the University of Southern California and played on their women's basketball team for four years, winning NCAA championships in 1983 and 1984 with star teammate Cheryl Miller, but left in 1986 before earning a degree. She played on international women's basketball teams in Spain and Italy for a decade before returning to the US to play for the Houston Comets. While abroad she learned to speak Italian fluently.