In 2018, Nye guest-starred in an episode of "Blindspot", "Let It Go", playing a fictionalized version of himself who is the father of the character Patterson. Nye's fictional self also alludes to his rivalry with Rodney McKay, which was established in the aforementioned "Brain Storm" episode of "Stargate Atlantis". Also in 2018, Nye made a second guest appearance on "The Big Bang Theory" as himself, together with fellow scientist Neil deGrasse Tyson, in the first episode ("The Conjugal Configuration") of the show's final season.