In , Lisenbee retired from baseball to run the family farm and to help grow crops for the Army. But he decided to make a comeback in , with the Syracuse Chiefs of the International League, a minor league team and in the latter part of the season, pitched a no-hitter at the age of forty-five. This game was considered a perfect record-setting event. Lisenbee had completed a no-hit, no-walk, and no-run game. According to Lisenbee, in an article published by The Leaf-Chronicle newspaper in 1945, he was hailed as man of the year in Syracuse sports and when he left town, the local fans gave him $200 in war bonds.