Jews began to settle in Grodno in the 14th century after the approval given to them by the Lithuanian Gran Duke Vytautas. During the next years, their status had changed several times and in 1495 the Jews were deported from the city and banned from settling in Grodno (the ban was lifted in 1503). In 1560 there were 60 Jewish families in Grodno. They were concentrated on the "Jewish street" with their own synagogue and "hospital". In the year 1578 the great synagogue of Grodno was built by rabbi Mordehai Yaffe (Baal ha-Levush). The synagogue was severely damaged in a fire in 1599.