An international since 2002 he made his debut on 21 January 2002, Segou in a Ghana, Morocco encounter at the Africa Cup of Nations: 2002, Amoah was an instrumental figure in Ghana's first qualification for the World Cup, scoring three goals in three consecutive and important qualifying matches. Matthew Amoah finished as Ghana's leading scorer in the 2010 FIFA World Cup qualifiers, his five strikes proving pivotal in the Black Stars' march to a second successive tournament. His tally added to the three goals he scored in the 2006 qualifiers that also made a major contribution to Ghana's march to their first-ever FIFA World Cup finals appearance. He also played in their World cup debut even though he did not score in any of the matches he played, his ability, runs and passes helped the team to the group of 16.