Since the trade to San Diego in 2006, Volek saw spot duty behind Philip Rivers. During the AFC Divisional Playoff game against the Indianapolis Colts on January 13, 2008, Volek replaced the injured Philip Rivers and led a fourth-quarter comeback over the defending champions. He completed 3 of his 4 passes, including a 15-yard pass on his second pass attempt. He also scored his first touchdown of the year on a one-yard quarterback sneak which allowed the Chargers to win the game, 28–24, and go to the 2007 AFC Championship Game against the New England Patriots.