When mobile-to-base links cannot be precisely coordinated, particularly due to the mobility of the handsets, a different approach is required. Since it is not mathematically possible to create signature sequences that are both orthogonal for arbitrarily random starting points and which make full use of the code space, unique "pseudo-random" or "pseudo-noise" sequences called spreading sequences are used in "asynchronous" CDMA systems. A spreading sequence is a binary sequence that appears random but can be reproduced in a deterministic manner by intended receivers. These spreading sequences are used to encode and decode a user's signal in asynchronous CDMA in the same manner as the orthogonal codes in synchronous CDMA (shown in the example above). These spreading sequences are statistically uncorrelated, and the sum of a large number of spreading sequences results in "multiple access interference" (MAI) that is approximated by a Gaussian noise process (following the central limit theorem in statistics). Gold codes are an example of a spreading sequence suitable for this purpose, as there is low correlation between the codes. If all of the users are received with the same power level, then the variance (e.g., the noise power) of the MAI increases in direct proportion to the number of users. In other words, unlike synchronous CDMA, the signals of other users will appear as noise to the signal of interest and interfere slightly with the desired signal in proportion to number of users.