Today the creek has given its name to the hamlet at its mouth, as well as the village of "Larryville" further upstream. Before it became a borough, Salladasburg was also known as "Larrys Creek" (from the name of its post office). The "First Fork" and "Second Fork" of Larrys Creek are named in the order in which they are encountered traveling upstream, with "Fork" here denoting a major tributary. "Lawshe Run", the major tributary of the Second Fork, is named for Robert Lawshe, who established a tannery in Salladasburg in 1848. "Seeley Run", a minor tributary entering the creek at Larryville, is named for Mr. Seely, who built the first sawmill on Larrys Creek in 1796. While the USGS uses "Seeley Run", it is still "Seely Run Road" that follows the stream. The First Fork, Canoe Run, Joes Run, and Wolf Run also have roads named for them.