Over the next four years the family lived in Charleston, and his mother bore four more children, one, of whom, Robert, lived less than a day. In September 1809, his sister Ann Caroline died of yellow fever. His father, having watched his ten siblings succumb to the same disease as children, moved his family permanently to Pendleton. For the rest of his life, the elder Samuel Maverick cautioned his children to always live in a healthful climate so that they would not fall victim to a tropical disease.