In 2006 Weisz starred in Darren Aronofsky's romantic drama "The Fountain". The "San Francisco Chronicle" found her portrayal of Queen Isabel "less convincing" than other roles. That same year, she provided the voice for Saphira the dragon in the fantasy film "Eragon"; and rejected an offer to star in "" due to script issues. The part eventually went to Maria Bello. Her subsequent films include the 2007 Wong Kar-wai drama "My Blueberry Nights", and Rian Johnson's 2008 caper film "The Brothers Bloom", alongside Adrien Brody and Mark Ruffalo. In 2009, she played the lead role of Hypatia of Alexandria in the historical drama film "Agora", a Spanish production directed by Alejandro Amenábar. "The New York Times" called her portrayal "adept", noting that she imparted "a sympathetic presence".