On the US "Billboard" Hot Latin Songs chart, "Te Lo Agradezco, Pero No" debuted at number 22 for the chart issue dated 10 February 2007. It entered the top ten of the chart two weeks later and ascended to the top in its fifth charting week on 10 March 2007 replacing "Manda una Señal" by Maná, spending a total of 14 weeks on the chart. It further managed to top the Latin Pop Airplay chart, and peaked at the fourth position on the Tropical Songs chart. At the end of 2007, "Te Lo Agradezco, Pero No" was ranked as the 36th best-selling Latin song in the United States. The song attained similar success on the Record Report charts in Venezuela, where it topped the Top Latino chart and climbed to the fourth position on the Pop Rock chart. In 2007, the single was certified Platinum by Productores de Música de España (PROMUSICAE) for shipment of 40,000 copies in Spain; its ringtone was also certified Gold in the country.