Since 1994, when she became communications director and spokesperson for Enough Is Enough, an American secular nonpartisan non-profit organization whose mission is to make the Internet safer for families and children, Hughes has been an advocate and speaker on the issue of protecting children online. Hughes became president and CEO of the organization in 2002. The organization has produced an Internet Safety 101SM program with the Department of Justice and other partners. She is the executive producer, host and instructor of the "Internet Safety 101" DVD series, which ran as a TV series on PBS, garnering Hughes an Emmy nomination in 2012 and the series an Emmy Award in 2013.