Meyer was born in Toledo, Ohio, grew up in Ashtabula, Ohio, and attended the University of Cincinnati, where he played football as a defensive back. During his time at the University of Florida, he coached the Gators to two BCS National Championship Game victories, during the 2006 and 2008 seasons. Meyer's winning percentage through the conclusion of the 2009 season (.842) was the highest among all active coaches with a minimum of five full seasons at a Football Bowl Subdivision (FBS) program.