Derek appeared in several more feature films during the 2000s, including "Frozen with Fear" (2000), "The Master of Disguise" (2002), for which she received her second Golden Raspberry Award for Worst Supporting Actress nomination, and "Malibu's Most Wanted" (2003). In 2006 Derek starred in 40 episodes of the 65-episode telenovela series "Fashion House". Derek had a featured role in the 2015 made-for-TV campy horror film "". Derek was reported to have participated in the 2016 Comedy Central roast of Rob Lowe but is absent from the eventual cast list.