The first European settlement in St. Francois County was made in the spring of 1796 at what is now known as Big River Mills by Andrew Baker, John Ally, Francis Starnater and John Andrews. They each located claims in 1794 but did not bring their families until 1796. Andrew Baker was the only one who had a house; the rest lived in camps. Baker, who built a large home along the north bank of Big River, established a community there. At one time he reportedly owned 200 slaves and was one of the wealthiest men in the area. Eventually all his children married and left the farm which consisted of . The farm was sold for taxes and later sold for $30 per acre. Several families settled that same year on Big River; among them were Elisha Baker, his son Elijah and Joseph Reed from Bois Brule Bottom. In 1798, Solomon George became the first to settle on Little St. Francois River.