The size of a silver cluster in the latent image can be as small as a few silver atoms. However, in order to act as an effective latent image center, at least four silver atoms are necessary. On the other hand, a developed silver grain can have billions of silver atoms. Therefore, photographic developer acting on the latent image is a chemical amplifier with a gain factor up to several billion. The development system was the most important technology that increased the photographic sensitivity in the history of photography.