McFadden started the 2010 season as a better player than he was in his first two seasons. Against the Tennessee Titans on September 12, McFadden rushed for 95 yards on 18 carries. In Week 2, McFadden rushed for 145 yards on 30 carries against the St. Louis Rams. McFadden rushed for 105 yards with a rushing touchdown against the Arizona Cardinals in Week 3. McFadden missed 4 games due to a knee surgery for a torn meniscus after getting injured on Oct 5 against the Houston Texans. Upon his return on October 24, 2010 against the division rival Denver Broncos, McFadden carried the ball 16 times for a total of 165 yards and 3 touchdowns. He also recorded 2 receptions for 31 yards and a touchdown. McFadden became only the 4th Raider to have 4 touchdowns in a game. Art Powell, Marcus Allen, and Harvey Williams were the others.