In December 2018, after United States Secretary of State Mike Pompeo announced the Trump administration was suspending its obligations in the Intermediate-Range Nuclear Forces Treaty in 60 days in the event that Russia continued to violate the treaty, Wyden was one of twenty-six senators to sign a letter expressing concern over the administration "now abandoning generations of bipartisan U.S. leadership around the paired goals of reducing the global role and number of nuclear weapons and ensuring strategic stability with America's nuclear-armed adversaries" and calling on President Trump to continue arms negotiations.