However, in the later Ottoman period the city developed as the main port on the Mediterranean for the overland trade from Baghdad and India, which had great importance until the establishment of the Egyptian overland route. Iskenderun served as a base, first for Genoese and Venetian merchants, then Western and Northern European merchants. The British Levant Company maintained an agency and factory here for 200 years, until 1825, in spite of high mortality among its employees because of regional disease, some due to lack of sanitation systems. During the 19th century the port grew, and the road to Aleppo was improved. The railway was built in 1912.