In the 2000s, Valletta began to focus on her career as an actress. She had her first major film role as a poltergeist in Robert Zemeckis's supernatural thriller "What Lies Beneath" (2000). She has since appeared in films such as "Hitch" (2005), "Transporter 2" (2005), "Man About Town" (2006), "Dead Silence" (2007), "Gamer" (2009), and "The Spy Next Door" (2010). In 2011, she moved to television, appearing in a recurring role as the fallen socialite Lydia Davis on ABC's drama television series "Revenge". In 2015, Valletta starred as villainous Carla Briggs in another ABC soap opera, "Blood & Oil".