In 776, "Flarlesheim superiori" had its first documentary mention in a donation document from Lorsch Abbey. From 1237 until the late 18th century, the Teutonic Knights ran a commandry in the village. From 1506, Ober-Flörsheim belonged to Electoral Palatinate and was made part of the "Oberamt" of Alzey. In the Thirty Years' War, Swedish troops laid waste the commandry and the village. In 1689, the village was dealt a further blow by French troops under King Louis XIV when they laid the Palatinate waste during the Nine Years' War.