Originally, the north end of the highway was in Norwood as a direct route connecting Norwood with Centerville, Mississippi appears not to have existed at the time. By 1927, Route 91 had been extended, curving northwest to closely follow what was then the Yazoo and Mississippi Valley Railroad to the Mississippi state line. Otherwise, the route remained essentially the same up to the 1955 Louisiana Highway renumbering. By this time, the Yazoo and Mississippi Valley line had been absorbed into the Illinois Central Railroad.