Probably around 1645 the family moved to Amsterdam, where Van den Enden started an art shop in the Nes. Only a few engravings and one pamphlet published by him are known. After the bankruptcy of his art shop, he opened a Latin school on the Singel. His pupils performed several classical plays in the Amsterdamse theatre and also a Neo-Latin play by his own hand, "Philedonius" (1657). By then the family had expanded: in 1648 the twins Anna and Adriana Clementina were born, in 1650 a son, Jacobus, in 1651 a daughter, Marianna, and in 1654 again a daughter, Maria (Anna, Jacobus and Maria probably died very young). In the late 1650s the famous philosopher Baruch Spinoza and the anatomist Theodor Kerckring were pupils at his school.