When the "Secret Invasion" begins, the Inhumans part of the story, by "Heroes" writer Joe Pokaski, digs into how the Inhuman Royal Family deals with the news that the Black Bolt they knew was a Skrull impostor. Medusa is shown fighting a Skrull that not only possesses her powers, but also possesses the powers of Mister Fantastic. Medusa heads into Kree space to get Ronan the Accuser to help look for the Skrull ship containing Black Bolt and her son. She succeeds in rescuing her family and returning to Attilan.