In 2016, Huo starred in historical medical drama "The Imperial Doctress", portraying Zhu Qizhen. It was one of the highest rated dramas that year, and Huo was awarded Most Popular Actor and Most Marketable Artist for his performance in "The Imperial Doctress" as well as "Love Me If You Dare" at the 1st China Television Drama Quality Ceremony. He next starred in the crime thriller "Inside or Outside" alongside Korean actor Jang Hyuk and Hong Kong star Simon Yam, as well as romantic comedy film "Suddenly Seventeen" and suspense thriller "Hide and Seek".