On December 29, 1927, Cutting was appointed as a Republican to the United States Senate to fill the vacancy caused by the death of Andrieus A. Jones. He served until December 6, 1928, when a duly elected successor, Octaviano Ambrosio Larrazolo, qualified to serve the remainder of the term, which expired March 3, 1929. Cutting was not a candidate in the special election to fill this vacancy, which took place on November 6, 1928, the same day as the general election in which the seat was up for a full six-year term, beginning March 4, 1929. Larrazolo was not a candidate for election to the full term, and Cutting was elected to it, returning to the Senate after only three months away. Cutting was re-elected in 1934, winning a very close race (with 76,226 votes to Democrat Dennis Chavez's 74,944) in a failed year for Republicans.