Back in Karakura Town, Uryū finds his father, Ryūken, who offers to restore his Quincy powers on the condition that Uryū never associate with Soul Reapers again. Uryū agrees and regains his powers, but soon discovers that Orihime has been captured by the Espada. He joins Ichigo and Chad in going to Hueco Mundo to rescue her. Upon meeting Rukia and Renji in Hueco Mundo, their group splits up upon arrival. Uryū defeats Cirucci Sanderwicci before meeting up with Renji to fight Szayelaporro Grantz. Just as they are about to be defeated, despite aid from Nel's Fracciónes, Mayuri indirectly comes to their aid. After his injuries are healed, Uryū holds Yammy at bay before protecting Orihime from Ulquiorra Shiffer during the Espada's fight with Ichigo. He tries to stop a nearly Hollowified Ichigo from mutilating the defeated Ulquiorra, and is attacked himself, but is saved by Ulquiorra, who dies shortly afterwards. He remained with Orihime for the duration of the final battle against Aizen.