The route heads into the borough of New Bloomfield and becomes West Main Street, passing homes. PA 274 heads into the downtown area and comes to a traffic circle, where it intersects PA 34. At this point, PA 34 continues east on Main Street and PA 274 turns south to join PA 34 on South Carlisle Street, running past more residences. The road turns east to head back into Centre Township and become Spring Road, winding southeast through farms, woods, and residences. PA 34/PA 274 becomes the border between Carroll Township to the west and Wheatfield Township to the east, heading through agricultural areas with a few homes before continuing into forests. In Mecks Corner, PA 274 splits from PA 34 by heading southeast onto Bloomfield Road into Wheatfield Township, soon curving to the northeast. The route heads through wooded areas with some fields and homes, turning east. The road continues through more agricultural areas with some woodland and residences, heading southeast and passing through Roseglen. PA 274 enters Penn Township and heads through more rural areas with some residential development. The route becomes the border between the borough of Duncannon to the north and Penn Township to the south before ending at an interchange with the US 11/US 15 freeway, where the road also crosses the Appalachian Trail. From here, the road continues northeast into Duncannon as South Market Street.