Medusa has been known to join the Fantastic Four as a full team member for brief periods of time. She became a temporary replacement for Susan Richards, known as the Invisible Girl at that time, when on family leave, caring for her comatose son Franklin Richards. Through her relations with the Fantastic Four, Medusa and Black Bolt have sought to achieve an understanding and peace between the races of Earth and Attilan. Nevertheless, the Inhumans have been forced to relocate their home of Attilan several times due to continued human hostility.