North of NY 252, NY 15A passes under the CSX Transportation-owned West Shore Subdivision and crosses into Brighton. Just past the town line, the route connects to Clay and Brighton–Henrietta Town Line Roads by way of a grade-separated intersection north of the railroad overpass. It continues onward, passing along the west side of the sprawling Monroe Community College campus to another interchange with I-390. NY 15A passes over the Erie Canal and enters the city of Rochester shortly afterward. Once in the city, the route passes by two large office campuses south of Westfall Road and several blocks of homes north of the street before merging back into NY 15 (Mount Hope Avenue) at a junction east of Strong Memorial Hospital.