He was married to Judith Sale, daughter of Cornelius Sale and Jane Dawson of Amherst County, Virginia. His daughter Matilda Pope married John Williams Walker, who became Alabama's first senator, and was the mother of LeRoy Pope Walker, Confederate secretary of war and brigadier general; Richard Wilde Walker, Confederate States senator; Percy Walker, United States representative; and several other children. Another daughter, Maria Pope, married Thomas George Percy, Sr., and was the ancestor of such notables as Senator LeRoy Percy of Mississippi, the poet William Alexander Percy, Senator Charles H. Percy of Illinois, and the author Walker Percy.