Once named Walker's Station for Lewis B. Walker's store, when a post office was established on March 2, 1859. Lewis B. Walker was the first postmaster. It was named Glendale for the new train station, which in turn was possibly named for the hometown of a railroad employee. A train depot was built in Glendale along the L & N Railroad tracks in 1864. It was remodeled into a "combination station" in 1905 and the old station became a freight room with two waiting rooms for passengers and an agent's office. The original depot was torn down in the 1930s.