Between 1734 and 1741, Weiser became a follower of Conrad Beissel, a German Seventh Day Baptist preacher. For six years, he lived at the monastic settlement, Ephrata Cloister, in the Ephrata Township, Lancaster County, Pennsylvania. His wife lived there only a few months before returning to their farm. Weiser would visit her frequently enough, however, to father four more children. In addition, he took leaves of absence for diplomatic duties, such as those in 1736 and 1737. Weiser left the cloister in 1741 after becoming disenchanted with the leadership of Beissel and returned to the Lutheran faith of his father.