The series won the Eisner Award for Best Continuing Series of 1996 and 2000; Best New Graphic Album of 2000; and Best Publication Design of 1995, 1996, 1997, and 2002. Furthermore, an "Acme Novelty Library" display stand won the Eisner Award for Best Comics-Related Product of 1998. Ware won the Eisner Award for his work in "Acme Novelty Library" for Best Artist/Writer-Drama of 2008; Best Artist/Writer of 2009; Best Colorist of 1996, 1998, 2001 and 2006; and Best Letterer of 2009.