Nixon began a television presenting career, co-hosting "Top of the Pops Reloaded". He then formed a presentational double-act on the BAFTA winning CBBC show "Level Up", with Mark Rhodes, from 3 April 2006 until 1 September 2006. He worked on the children's Saturday morning show, "TMi", on BBC Two, which started on 17 September 2006. The series finished on 7 February 2007. Sam returned to television at the beginning of the Easter holidays 2007 in a show called "Do Something Different" which he presents with Rhodes and Ayesha Asantewaa to attempt to get 1 million children to "try something new". Sam (along with Mark Rhodes) is the presenter of "TMi Friday" on the CBBC Channel.