"I Eat Your Skin" was made by Del Tenney Productions. It is a regional film, defined by regional horror film specialist Brian Albright as one that is "(a) filmed outside of the general professional and geographic confines of Hollywood; (b) produced independently; and (c) made with a cast and crew made up primarily of residents of the states in which the film was shot." Although set on an island in the Caribbean, the movie was filmed in Miami Beach and Key Biscayne, Florida.