When Wayne County was formed in 1818, the territorial legislature appointed five commissioners to govern it. They chose a small settlement called Cedar Cabin on the St. Francis River to be the county seat. Renamed Greenville, it had grown to about 1,000 by the turn of the 20th century. By 1940, however, the population had declined to 572. In 1941, the remaining inhabitants were forced to relocate because of the construction of Lake Wappapello. This new town's population had fallen to 270 in 1950, but has now increased to about 563.