Aldrich-Blake was the first to perform operations for cervical and rectal cancers. She led the British surgeons in taking on the Wertheim operation for carcinoma of the cervix. Aldrich-Blake added a piece to the "Practitioner's Encyclopedia of Midwifery and Diseases of Women" named "Pain as a symptom of pelvic trouble" and a piece on "Abdomino-perineal excision of the rectum by a new method" in the "British Medical Journal" in 1903. She held a chair position as a vice-president of the Section of Obstetrics and Gynaecology in 1924 that was a part of the British Medical Association.