I-182 enters Pasco and turns 90 degrees southeast towards the city center after intersections with Broadmoor Boulevard and Road 68 at Gesa Stadium. The freeway intersects US 395 in a trumpet interchange, beginning a third concurrency, and 20th Avenue in a partial cloverleaf interchange near Columbia Basin College and the Tri-Cities Airport, utilizing an eastbound collector-distributor lane. I-182 continues east, forming the northern boundary of downtown Pasco, intersecting 4th Avenue before crossing over a BNSF-owned railyard. The freeway reaches a cloverleaf interchange with SR 397, where US 395 splits off to travel north towards Spokane. I-182 ends southeast of the interchange, while the roadway continues southeastward towards Burbank and Walla Walla as US 12.