The Bible also speaks of wine in general terms as a bringer and concomitant of joy, particularly in the context of nourishment and feasting. Wine was commonly drunk at meals, and the Old Testament prescribed it for use in sacrificial rituals and festal celebrations. The Gospel of John recorded the first miracle of Jesus: making copious amounts of wine at the wedding feast at Cana. Jesus instituted the ritual of the Eucharist at the Last Supper during a Passover celebration, he says that the "fruit of the vine" is a "New Covenant in blood," though Christians have differed on the implications of this statement (see Eucharistic theologies contrasted). Alcohol was also used for medicinal purposes in biblical times, and it appears in that context in several passages—as an oral anesthetic, a topical cleanser and soother, and a digestive aid.