US 50 comes to an eastbound exit and westbound entrance with US 50 Bus., which heads southeast into Salisbury along Ocean Gateway. At this point, US 50 becomes a four-lane freeway called the Salisbury Bypass that bypasses Salisbury to the north and east. From here, the route continues east and reaches a diamond interchange with Naylor Mill Road (US 50UA). Following this interchange, the freeway heads through wooded areas with some nearby residential development, coming to a bridge over the Wicomico River. The road passes through the Northwood business park on an earthen viaduct, crossing over the Delmarva Central Railroad's Delmarva Subdivision line before coming to an eastbound exit and westbound entrance with Northwood Drive. Past this interchange, US 50 comes to an interchange with US 13 and the northern terminus of US 13 Bus. at Salisbury Boulevard in a business area to the southwest of The Centre at Salisbury shopping mall. At this point, US 13 becomes concurrent with US 50 on the Salisbury Bypass, and the two routes head east through a mix of farmland and woodland with some homes. The freeway curves to the south and passes over the Delmarva Central Railroad's Willards Industrial Track line and MD 346 without an interchange. The road comes to a partial cloverleaf interchange with the eastern terminus of US 50 Bus. at Salisbury Parkway, at which point US 50 splits from the Salisbury Bypass to continue east as Ocean Gateway and US 13 continues south along the Salisbury Bypass.