Santos also enjoyed a deep run in the 2011–12 CONCACAF Champions League. Quintero scored his first goal of the tournament on 27 July 2011 as "Los Guerreros" won the first leg of their qualifier with Olimpia 3–1. Santos lost the second leg, but advanced 4–3 on aggregate. Quintero scored his second of the tournament on 13 September, helping Santos secure a 4–1 over the Colorado Rapids. He made his final of 3 appearances in the group stage on 22 September, scoring twice and assisting on another as Santos defeated A.D. Isidro Metapán 6–0. He missed the final three matches of the group stage and the quarterfinals due to an injury. Quintero returned for the semifinal first leg on 28 March 2012 and helped to open the scoring by assisting Hérculez Gómez in the 30th minute, however Toronto would respond and level the score seven minutes later. After the match, Quintero got a red card after he got in an altercation with Toronto defender Ashtone Morgan, prompting both benches to clear and run onto the field. In the first leg of the final, Quintero had some dangerous moments, but Santos fell to Monterrey 2–0. In the second leg, Quintero found Daniel Ludueña just outside the penalty box, who then turned and rocketed a shot into the top right corner right before halftime. In the second half Quintero helped to create another goal, dribbling down the right flank before whipping in a cross that the Rayados keeper knocked off target, but pinballed around the box before Oribe Peralta was able to put it into the net and level the aggregate score. Monterrey would respond in the 82nd minute and hold on to deny Santos their first continental trophy in club history.