SR 25 enters Perrysburg passing through commercial properties and having an interchange with Interstate 475 (I–475) and US 23. At Findlay Street the highway curves northeast and becomes a four-lane undivided highway (West Boundary Street), passing through commercial and residential properties. The road crosses over a set of railroad tracks, before an intersection with SR 65 (W. River Road). SR 65 heads northwest concurrent with SR 25 and the concurrency has an intersection with US 20 (W. Front Street). At the intersection with US 20, SR 65 turns east onto US 20 and SR 25 turns northwest onto US 20 (Maumee-Western Reserve Road). The concurrency heads northwest as a four-lane undivided highway passing through woodland and crossing over the Maumee River. The concurrency enters Maumee as Conant Street and has an intersection with US 24 (Anthony Wayne Trail). At this intersection, SR 25 turns northeast, concurrent with US 24.