Vinci kicked off her 2015 season by playing at the ASB Classic. She lost in the first round to seventh seed CoCo Vandeweghe, 7–5, 2–6, 3–6. The following week, she played at the Hobart International. Seeded ninth, Vinci made it to her first quarterfinals of the year defeating wild-card Olivia Rogowska and Annika Beck. In the quarterfinals, she fell to eventual champion Heather Watson 7–6, 6–2. At the Australian Open, Vinci overcame Bojana Jovanovski to reach round two but lost to 10th seed Ekaterina Makarova, 2–6, 4–6.