During the early part of Clark's career, she focused on creating small monochromatic paintings which were done in black, gray, and white. During the 1960s, her work became more conceptual and she used soft objects that could be manipulated by the art spectator. Clark later moved on to co-found the Neo-Concrete movement, which was joined by fellow Brazilian Hélio Oiticica. Throughout her career, Clark's art has involved an exploration of art's effect on spectators. One of her primary goals as an artist was to appeal to the average, everyday person, not just the bourgeois crowd.