Quintero got off to a slow start in the 2016 Clausura, only having one assist and zero goals in his first 7 appearances. After he served his suspension for a red card he received in matchweek 7, Quintero scored twice and added an assist as América defeated Morelia 4–1. Quintero ended the Apertura with 6 goals and 2 assists, with 5 of the goals and 1 of the assists coming in the 5 games immediately following his suspension in matchweek 7. In the quarterfinals of Liguilla, Quintero had the go ahead assist in the second leg to help América advance past Guadalajara. After getting a 1–0 win in the first leg of the semifinal, Monterrey won the return leg 4–2, eliminating América.