The pointed pattern is a form of partial albinism, resulting from a mutation in tyrosinase, an enzyme involved in melanin production. The mutated tyrosinase enzyme is heat-sensitive; it fails to work at normal body temperatures, but becomes active in cooler (< 33 °C) areas of the skin. This results in dark colouration in the coolest parts of the cat's body, including the extremities and the face, which is cooled by the passage of air through the sinuses. All Siamese kittens, although pure cream or white at birth, develop visible points in the first few months of life in colder parts of their body. By the time a kitten is four weeks old, the points should be sufficiently clearly distinguishable to recognise which colour they are. Siamese cats tend to darken with age, and generally, adult Siamese living in warm climates have lighter coats than those in cool climates. Originally the vast majority of Siamese had seal (extremely dark brown, almost black) points, but occasionally Siamese were born with "blue" (a cool grey) points, genetically a dilution of seal point; chocolate (lighter brown) points, a genetic variation of seal point; or lilac (pale warm gray) points, genetically a diluted chocolate. These colours were at first considered "inferior" seal points, and were not qualified for showing or breeding. All of these shades were eventually accepted by the breed associations, and became more common through breeding programmes specifically aimed at producing these colours. Later, outcrosses with other breeds developed Siamese-mix cats with points in other cat colours and patterns, including Red and Cream point, lynx (tabby) point, and tortoise-shell ("tortie") point.