Construction started in 1966, with General Castello Branco, the first president of Brazil's military regime, laying the cornerstone of the Institute of Biology, which was inaugurated in 1968, and classes started in the new campus on the following year. In 1971 the area of the campus was expanded by , more than doubling its size, to accommodate the move of the School of Medical Sciences, until then located across several buildings in Campinas, to the new campus. This expansion saw the construction of a massive public hospital, the Hospital das Clínicas (HC), which began serving the public in 1979.