There have been examples of Uncle Ben remaining alive in alternative timelines, including stories featured in Marvel's "What If" (one of which he forces Peter to unmask in front of J. Jonah Jameson), and a storyline of the 1994 "Spider-Man" animated series featured a universe where Uncle Ben had never died, and Peter Parker became a successful industrialist, having never really bothered to use his powers responsibly as everything always seemed to work out for him. This fact is used to defeat the rampaging Spider-Carnage by exposing him to the one person he will trust and listen to: the Uncle Ben of that reality.