In 1675, she married Flavio Orsini, Duke di Bracciano (1620–1698). The marriage was far from harmonious, but her husband left her his fortune (popular imagination thought it to be huge, but in reality, the duke was almost bankrupt) and the leadership of the French party in Rome. It brought her a series of lawsuits and troubles with Livio Odescalchi, nephew of Pope Innocent XI, who claimed that he had been adopted by the duke. Eventually, the widow sold the title and estates to Odescalchi.