Katherine Langley served as chairman of the Pike County Red Cross Society during the First World War. Moving to Washington D.C. in 1907, she served as secretary for her husband for the eighteen years he served as the Republican representative for the 10th District. She held numerous appointed and elected public positions including vice chairman of the Republican State Central Committee of Kentucky 1920–1922—she was the first woman member of that committee and founded the Kentucky Woman's Republican State Committee which she chaired in 1920. She served as an alternate delegate to the Republican National Convention in 1920 and delegate in 1924. She clerked for the Committee on Public Buildings and Grounds which her husband chaired. John Langley was convicted of violating the Volstead Act by selling alcohol illegally and trying to bribe a federal officer. After his appeal was denied by the U.S. Supreme Court, in 1926 he resigned from his office in Congress as Kentucky's representative for the 10th District. Katherine Langley ran on the Republican ticket using her husband's arrest as part of a government conspiracy, and she soundly defeated her husband's successor, Andrew J. Kirk, in the primary.