"Lucky Numbers" earned negative reviews from critics. On Rotten Tomatoes it has a rating of 23% based on 97 reviews. The site's consensus states: "Nora Ephron's attempt at dark comedy is an uneven product, both in terms of the direction and the acting. The characters are unlikable to the point where you don't care what happens to them, and Ephron condescends to the material." On Metacritic it has a score of 31 out of 100 based on reviews from 30 critics, indicating "generally unfavorable reviews". Audiences surveyed by CinemaScore gave the film a grade F.