Settling permanently in Rome, Wyatt practised his profession there with great enthusiasm and success, and from 1831 until his death was a frequent exhibitor at the Royal Academy. Among his best works were "Ino and the infant Bacchus", "Girl at the Bath", "Musidora" (at Chatsworth), and "Penelope", "The Huntress", and "Flora" (all in the royal collection). Several of these have been engraved for "The Art Journal". The ‘Penelope’ was a commission given by the queen to Wyatt at the time of his only visit to England in 1841. Wyatt was a highly accomplished artist, particularly excelling in his female figures, which in purity of form and beauty of line rivalled those of his master Canova. A woodcut portrait, from a drawing by S. Pearce, accompanies a memoir of him in "The Art Journal", published in 1850.