Marlow joined the Great Western Suburban League for the 1911–12 season. They finished bottom of the league in 1912–13 following a points deduction, and again in 1922–23. In 1924 they left the league, dropping into the Reading & District League. After moving to the Alfred Davis Memorial Ground in 1928, the club joined Division Two West of the Spartan League. They won the division in 1929–30, earning promotion to Division One. In 1937–38 the club were Division One champions and were promoted to the Premier Division. During World War II the club played in the Great Western Combination. After the war they were placed in the Western Division of the Spartan League for the 1945–46 season, but did not finish high enough to earn a place in the Premier Division the following season.