In an 18-year career, Yost played in 2,109 games, accumulating 1,863 hits in 7,346 at bats for a .254 career batting average along with 139 home runs, 683 runs batted in and an on-base percentage of .394. He ended his career with a .957 fielding percentage. Yost led the American League in bases on balls on six occasions and logged 1,614 over his 18-year career, ranking him 11th on the all-time walks list. In 1956, he had a .412 on-base percentage while posting a .231 batting average, the lowest batting average with a .400 on-base percentage in major league history. Yost hit 28 home runs to lead off a game, a record which stood until Bobby Bonds broke it in the 1970s.