Over the years conflict developed between her husband and her brother, especially over the relationship of the double-duchies of Schleswig-Holstein and his small appanage around Sonderborg on one hand and the Danish monarchy on the other. She remained loyal to the Danish Royal House or rather, to her brother, throughout the differences, and acted as his agent with her spouse. In 1810 she worked actively to stop the Duke's attempts to be chosen as successor to the Swedish throne, which were linked with the duke's younger brother Charles August of Augustenburg becoming chosen by Swedes and then dying, after which Jean-Baptiste Bernadotte, Marshal of France and Prince of Ponte Corvo, was elected.