Port Jefferson's main street forms a section of New York State Route 25A, a scenic and historic route through Long Island's North Shore from the New York City borough of Queens eastward to Calverton. Just southeast of the village is the eastern terminus of New York State Route 347, a multilane divided highway that connects to the Northern State Parkway in Hauppauge. New York State Route 112, an important north–south route, begins just south of the village and runs to Patchogue, with a dedicated bicycle lane along much of the route.