On 14 July 1881, Daniel Stott died of strychnine poisoning at his home in Boone County, Illinois, after Cream supplied him with an alleged remedy for epilepsy. The death was attributed to natural causes, but Cream wrote to the coroner blaming the pharmacist for the death after again attempting blackmail. This time, Cream was arrested, along with Mrs Julia A. (Abbey) Stott, who had become Cream's mistress and procured poison from Cream to do away with her husband. She turned state's evidence to avoid jail, laying the blame on Cream, which left him to face a murder conviction on his own. He was sentenced to life imprisonment in Joliet Prison.