Thompson began playing in one-day tournaments in October 2010 on the Fuzion Minor League Golf Tour, a developmental tour aimed at men trying to move up to the next level of professional golf. On the Fuzion Tour, women play with tees moved up so that they play 94% of the distance that the men play. She returned to play against women in February 2011 at the Women's Australian Open and the ANZ Ladies Masters, where she missed the cut and finished T42 respectively. Returning to the United States, she won a one-round Fuzion Tour event, on February 21, at her home course in Coral Springs, Florida. Tied after 18 holes, she beat Brett Bergeron on the second playoff hole, for her first professional win. In March, Thompson attempted the Monday qualifier for the LPGA Kia Classic, but failed to qualify.