SR 5 turns northwest onto US 224 and enters Huntington on the southeast side of the city. The concurrency runs along Jefferson Street before crossing over the Little River. North of the river US 224/SR 5 becomes one-way pairs with northwest bound traffic on Warren Street while southeast bound traffic on Cherry Street. The northwest bound one-way passes southeast and northeast around the Huntington County Courthouse. The one-way pairs ends at Park Drive with US 224 and SR 5 heading northwest on Jefferson Street. North of downtown the street passes through residential properties before the landscape surrounding the street changes to become commercial properties. The road has an intersection with US 24/SR 9, that this intersection US 224 ends. SR 5 heads northwest solo still passing through commercial properties before SR 5 leaves the city of Huntington. Northwest of Huntington SR 5 has a rural intersection with the eastern end of SR 16, in rural Huntington County. The road has an intersection with SR 114 at the Huntington-Whitley county line, after which SR 5 enter Whitley County.