The next year was spent at Charleston, except for a training cruise to Guantanamo Bay in March. However, on 9 January 1951, the ship got underway again for another cruise to the Mediterranean. She visited Oran, Palermo, Athens, and Naples during this deployment, again taking part in U.S. 6th Fleet's peace-keeping operations. Arriving at Charleston on 17 May 1951, "Jeffers" engaged in minesweeping and antisubmarine exercises until her next scheduled Mediterranean cruise on 5 June 1952. She operated with 6th Fleet aircraft carriers and destroyers until returning to her home port on 13 October.