Mike Esposito was born in New York City, New York, with a musician father who in 1928 fronted the band Ralph Perry and His Orchestra, and later was a grocer. Esposito graduated from The High School of Music & Art, then in Harlem, where one of his classmates and friends was future comics artist Ross Andru, with whom he would collaborate on flip-book animation. One early artistic influence was Milt Caniff's "Terry and the Pirates", while another was Lev Gleason Publications crime comics artist George Tuska, of whom he said,