Stipe has repeatedly stated that the song's lyrics are not about religion. The phrase "losing my religion" is an expression from the southern region of the United States that means "losing one's temper or civility" or "feeling frustrated and desperate." Stipe told "The New York Times" the song was about romantic expression. He told "Q" that "Losing My Religion" is about "someone who pines for someone else. It's unrequited love, what have you." Stipe compared the song's theme to "Every Breath You Take" (1983) by The Police, saying, "It's just a classic obsession pop song. I've always felt the best kinds of songs are the ones where anybody can listen to it, put themselves in it and say, 'Yeah, that's me.'"