In 1975, Meyer played his first full season at the major league level. He played left field and first base in the field. During the fifth inning of a game against the Boston Red Sox on April 25, Meyer hit a home run to break up Luis Tiant's perfect game bid. One day after hitting the game-winning home run for the Tigers against the Milwaukee Brewers on May 7, Meyer committed a throwing error that let the deciding Texas Rangers' run score. He batted .236 with 56 runs scored, 111 hits, 17 doubles, three triples, eight home runs, 47 RBIs, and eight stolen bases in 122 games played during the 1975 season. Meyer led the American League that year in plate appearances per strikeout with 18.8, which was over four points more than Mickey Rivers, who was second in the league in that statistic.