With the second season beginning in May 2006, the Diablos had an air of hope around them and were expected to contend in their new league. However, the team had vastly changed from the year before thanks to the purchase of closer Derrick DePriest by the Kansas City Royals on February 13, 2006. Also, upon Marshalls request, several members of the San Angelo Colts were signed, giving the Diablos possibly the most powerful offensive unit in the league, but the pitching staff that had been so mediocre the year before was unchanged. The team stumbled badly at the start of the season. The offense was dormant through much of the time, a factor that was worsened when offensive star Juan Camacho was bought by the Chicago White Sox on May 29. With the team floundering, on June 16, 2006, Marshall was released and replaced in the coming days by former major league pitcher Butch Henry, a graduate of El Paso's Eastwood High School. Though Henry provided some improvement, the team was still terrible and continued to struggle. The Diablos would lose shortstop Albenis Machado on August 13 when he was sold to the Chicago Cubs and eight days later would be on the receiving end of a no-hitter by Fort Worth Cats pitcher Joel Kirsten. The Diablos would ultimately finish last in the Southern Division.