"Jeffers" spent the first half of 1953 in training off the Virginia Capes, departing Norfolk on 16 September for operations with the aircraft carrier and units of the Royal Canadian Navy in the Mediterranean. She returned to Charleston 3 February 1954. Operations from New York to Key West and Havana occupied the destroyer-minesweeper until she decommissioned at Charleston on 23 May 1955. She entered the Charleston Group, Atlantic Reserve Fleet as DD-621, having been reclassified on 15 January 1955. "Jeffers" was stricken from the register on 1 July 1971 and later sold on 25 May 1973 and broken up for scrap.