Tboung Khmum District () is a district ("srok") located in Tboung Khmum Province, Cambodia. The district capital is Tboung Khmom town located around 20 kilometres east of the provincial capital of Kampong Cham by road. Tboung Khmum was formerly a central district of Kampong Cham before Tboung Khmum Province was formed from land formerly part of Kampong Cham. The district shares no borders with other provinces and is home to the huge Chup Rubber plantation. The plantation covers much of the land area of the district and contributes a large proportion to the district and provincial economy.