Additionally, Bramhall attempted to defend the English Church from attacks from the Roman Catholic Church. In 1653, he countered Théophile Brachet de la Milletière's restatement of the doctrine of transubstantiation with a reply that restated the justifications of the Anglican doctrine of Real Presence. He also attacked the Ultramontanists of France. Bramhall's "A Just Vindication of the Church of England from the Unjust Aspersion of Criminal Schism" (1654) was answered by the titular Bishop of Chalcedon, and Bramhall replied to this with "Replication" in 1656, where he prays that he might live to see the day when all Christian churches united again.