Historically, Towamencin has leaned Republican. Prior to the founding of the Republican Party, the township was known to favor the Federalist Party and the Whig Party. In the 1832 Pennsylvania gubernatorial election, Anti-Masonic candidate Joseph Ritner won 85% of the vote in Towamencin. Despite being a descendant of one of Towamencin's founding families, Jacksonian Democrat Jacob Fry Jr. won only 13 of Towamencin's votes in his 1836 campaign for Pennsylvania's 5th congressional district, compared to 77 votes for Whig candidate Daniel M. Mulvaney. In 1863, the township voted Republican by a margin of 186 to 79, and in the 1896 United States presidential election the township favored William McKinley by a margin of 245 to 36. In the 2001 municipal election, five Republicans ran for the Board of Supervisors compared to one Democrat, and following the 2019 election all members of the Board of Supervisors were Republicans. Republicans also hold a slight edge in voter registration. As of May 27, 2020, there were 12,876 registered voters in the township. Of those, 5,488 (42.62%) were registered Republicans, compared to 5,418 (42.07%) registered Democrats, with the remainder unaffiliated or members of third parties.