By 1914, the community had been reached by four railroads: the International and Great Northern; the Galveston, Houston and Henderson; the Missouri, Kansas and Texas; and the Interurban. At that time, La Marque had both a railroad station and general store located in a private home. The town's population reached 500 in 1914 and 1,500 by 1952, when it had 90 businesses. As it grew together with nearby Texas City, La Marque served as a residential community for employees at nearby industrial facilities (e.g., chemical plants and refineries) in the La Marque-Texas City area, as well as the Galveston Island Medical Center. The town had a population of 17,000 and 130 businesses in 1977. In 1988, it had 15,697 residents and 158 businesses, and in 1991, some 14,258 residents and 272 businesses.