US 70S begins at a junction with US 70 and SR 24 as the Charlotte Pike, and runs concurrently with SR 1. The road descends to an interchange with I-40, before passing through the community of Bellevue and intersecting SR 251. After this, US 70S enters the urban Nashville area along Harding Pike, intersecting SR 100 and then crossing I-440 as West End Avenue. US 70S and SR 1 merge with US 431 and SR 106 and crosses the I-40 and I-65 freeway as Broadway. At that interchange, the one-way couplet of US 70 and SR 24 meets US 70S, and all these routes continue into downtown Nashville. At the intersection of Rosa Parks Boulevard and Broadway, US 31 and US 41 run concurrently with the other routes on 8th Avenue South and then Lafayette Street, while US 431 splits off with US 31 and US 41 headed north, and US 70 and SR 24 continue east. US 31 eventually continues south, splitting from the other routes. US 70S and SR 1 and US 41 come to an interchange with I-24 near the I-40 interchange, before the three routes leave the Nashville area as Murfreesboro Pike, intersecting SR 155 and passing under the runways of Nashville International Airport.