His final race of 2004 was the Breeders' Cup Classic at Lone Star Park, run over a distance of miles. The excellent field included 2002 Horse of the Year Azeri, defending Breeders' Cup winner Pleasantly Perfect, American Classic winners Funny Cide and Birdstone, and multiple stakes winners Roses in May and Perfect Drift. Pleasantly Perfect went off at almost identical odds to Ghostzapper, with Ghostzapper a slight favorite. There were several factors of concern to the bettors, starting with the fact that Ghostzapper had never run at the distance. Another issue was trainer Bobby Frankel's poor record at the Breeders' Cup despite consistently training some of the best horses in the country. And then there was the fact that Ghostzapper drew post position one and risked getting trapped on the rail in heavy traffic. His exercise rider, Nuno Santos, was not concerned. "Drawing the rail doesn't matter, wire-to-wire", he said a few days before the race. "Believe me, no worries. This horse is unreal, a freak, and everyone is going to see it on Saturday. You're going to see a Secretariat type of race. I can feel him getting stronger every day, and I've never been as confident in a horse as I am with this guy, and that includes Azeri. It's another world. They're going to have to wait years and years to see another one like this." Frankel concurred. "If I don't screw him up and he goes into the Breeders' Cup as good as he is right now, he can't lose", he said. "It'll be no contest; that's all I'm telling you. That's how good this horse is."