US 50 continues east along Ocean Gateway, a four-lane, at-grade divided highway with a wide median, and passes to the north of Arthur W. Perdue Stadium, the home ballpark of the Delmarva Shorebirds baseball team. The route intersects Hobbs Road and heads through commercial areas, with the John Deere Drive (MD 992A) frontage road parallel to the south. The road runs through woods and crosses Beaverdam Creek before heading near more commercial development, passing to the north of Wor-Wic Community College past the Walston Switch Road intersection. US 50 traverses forests before running through a mix of farmland and woodland, reaching an intersection with Parsonsburg Road, which leads north to Parsonsburg, and Eastside Road (MD 992B). The route continues east through more rural land and comes to a junction with the southern terminus of MD 353, which heads north into Pittsville. The road runs through farmland with some woods, with MD 346 parallel a distance to the north. US 50 reaches an intersection with MD 354, which heads north into Willards. From here, the route continues into wooded areas and crosses the Pocomoke River.