Hellenistic Judaism was a form of Judaism in classical antiquity that combined Jewish religious tradition with elements of Greek culture. Until the fall of the Western Roman Empire and the early Muslim conquests of the eastern Mediterranean, the main centers of Hellenistic Judaism were Alexandria in Egypt and Antioch in Syria (now in southern Turkey), the two main Greek urban settlements of the Middle East and North Africa region, both founded at the end of the fourth century BCE in the wake of the conquests of Alexander the Great. Hellenistic Judaism also existed in Jerusalem during the Second Temple Period, where there was conflict between Hellenizers and traditionalists.