On his father's side, the Hatton pedigree is said to be "traced beyond records". In the reign of Henry VII, Henry Hatton of Quisty Birches in Cheshire married Elizabeth, sole heiress of William Holdenby of Holdenby, Northamptonshire. Their son, John Hatton, settled at Holdenby and had three sons, of whom Christopher Hatton's father, William, was the eldest. He is said to have had two brothers, Thomas and William, and a sister Dorothy (died 1569), who married first John Newport (died 1566) of Hunningham, Warwickshire, then William Underhill (died 1570) of Idlicote, Warwickshire, whose son, also William Underhill (died 1597), sold New Place to William Shakespeare.