The district is easily accessed by road from Kampong Cham city, Kratie or Prey Veng. Tboung Khmum is one of the largest districts in Tboung Khmum Province both by land area and by population, and only Memot district has a larger area. National Highway 7 bisects the district running from east to west. National Highway 11 runs from Nhek Loeung in Prey Veng Province and ends at Slab Kadoung on National Highway 7 in Tboung Khmum district. National road 73 begins near the eastern border of the district and runs north to Chhloung town in Chhloung District in Kratie.