The Andru-Esposito team first drew the flagship Marvel Comics character Spider-Man in the premiere (March 1972) of that superhero's first spin-off comic book, "Marvel Team-Up", nearly every issue of which featured Spider-Man paired with another hero. While Andru did not remain on the series, Esposito would go on to ink several issues, often those penciled by Gil Kane. Andru and Esposito eventually took over the flagship title "The Amazing Spider-Man". Esposito inked the vast majority of a nearly four-year run on the title, encompassing issues #147-150, 152-171, 177, 179-182, 185-186, 188, and 191 (Aug. 1975 - April 1979), all penciled by Andru except for three issues penciled by Sal Buscema and two by Keith Pollard. Esposito inked the feature stories in "The Amazing Spider-Man Annual" #4-5 (1967–1968), over Larry Lieber's pencils, with the latter issue introducing Peter Parker's parents; "Annual" #10 (Nov. 1976), over Gil Kane; and "Annual" #22, over Mark Bagley. Esposito additionally inked several issues apiece of "The Spectacular Spider-Man"; the children's comic "Spidey Super Stories"; and a host of Spider-Man miscellanea, such as "Spider-Man Giveaway: AIM Toothpaste Exclusive Collectors' Edition" (1980), and "Spider-Man Giveaway: National Committee for Prevention of Child Abuse" #1 (1984).