La Marque, also once known as Highlands and Buttermilk Junction, is an incorporated residential community on Interstate Highway 45, State Highway 3, and Farm Roads 519, 1765, and 2004, some 12 miles northwest of Galveston in northwestern Galveston County. The community was originally known as Highlands, probably for its location near Highland Creek, and was renamed in the 1890s when residents learned of another mainland community of the same name. Madam St. Ambrose, a French Catholic Ursuline Sister and postmistress, chose the new name, which in French means "the mark".