The newly qualified Aldrich-Blake began work at the New Hospital for Women and Children in London. She worked her way up to become the lead surgeon while also working at the city's Royal Free Hospital. At the Royal Free Hospital, she was the first woman to hold the post of surgical registrar in 1895 and also acted as an anaesthetist. Her position as consulting surgeon at the Royal Free started in 1919 and ended when she died in 1925. She also worked at the Canning Town Women's Settlement Hospital.