On November 28, 2020, Patricia and general manager Bob Quinn were both fired by the Lions. This came after lots of criticism about Patricia's abilities. The firing happened after the 4–5 Lions suffered back-to-back lopsided losses to drop to 4–7: a 20–0 loss to the Carolina Panthers on November 22 (the first time the Lions had been shut out since 2009) and a 41–25 loss to the Houston Texans during the Lions annual Thanksgiving Day game on November 26. Patricia finished his tenure in Detroit with a record in two and a half seasons. The Lions finished last in the NFC North division in both of Patricia's full seasons, and were in last place again at the time of his firing.