Tlass married Lamia Al Jabiri in 1958. She is a member of the Aleppine aristocracy. His marriage secured his position among the traditional elite and enabled him to advance socially. They have four children: Nahid (born 1958), Firas (born 1960), Manaf (born 1964), and Sarya (born 1978). His daughter Nahid was married to Akram Ojjeh, who was a Saudi millionaire arms dealer. Nahid Tlass has lived in Paris since the onset of Syrian uprising. His younger daughter, Sarya, is married to a Lebanese from Baalbak.