On November 22, 1720, at the age of 24, Weiser married Anna Eve Feck, a daughter of Johan Peter Feg and Anna Maria Risch. (Anna Eve Feck was born January 25, 1705 in Schoharie County, New York, and died June 11, 1781 in Womelsdorf, Berks County, Pennsylvania.) In 1725 the couple followed the Susquehanna River south out of New York and settled their young family on a farm in Womelsdorf, Pennsylvania near present-day Reading. The couple had fourteen children, of whom only seven reached adulthood.