In 1527, Andrea Doria invited Perino to Genoa to decorate the Palace of Fassolo, where he also executed numerous altarpieces and designs for tapestries. Perino accepted an invitation to Genoa, to help design decorate the newly rebuilt Palazzo del Principe for Andrea Doria. Fresco decoration began in 1529, starting with a now destroyed Quos Egos from the Aeneid. rapidly founded a quasi-Roman school of art in the Ligurian city. He ornamented the palace in a style similar to that of Giulio Romano in the Mantuan Palazzo Te, and frescoed historical and mythological subjects in the apartments, fanciful and graceful arabesque work with sculptural and architectural details. Among the principal works are: the "War between the Gods and Giants", "Horatius Cocles defending the Bridge", and the "Fortitude of Mutius Scaevola". The most important work of all, the "Shipwreck of Acneas", is no longer extant. From Genoa Perino twice visited Pisa, and began some painting in the cathedral.