Gilpin has appeared on the television series "Medium" and "Desperate Housewives". She has a supporting role on the television series "Make It or Break It" and has appeared on '. She starred alongside Teri Polo in the Lifetime movie "For the Love of a Child". In 2012, Gilpin guest-starred with another "Cheers" stalwart, Ted Danson, in '. She also had a recurring role in "Men at Work" on TBS as editor of "Full Steam" magazine. In the second season of "Scorpion", she was introduced as Katherine Cooper, a team superior in homeland security.