The following season, Samuelsson suffered a mild concussion after colliding with St. Louis Blues forward Vladimír Sobotka on December 5, 2010, causing him to miss one game. Two months later, he was named the NHL's Second Star for the week ending February 6, 2011. He scored two goals and six points in three Canucks victories to earn the distinction. While his goals total decreased to 18 in 2010–11, Samuelsson recorded his second consecutive 50-point campaign with a career-high 32 assists. Ranking fourth in team point-scoring behind the Sedins and Kesler, he helped the Canucks to the franchise's first Presidents' Trophy as the team with the NHL's best regular season record.