Jacqueline received superhuman powers as a result of a mutagenic reaction to a vampiric bite by the original Baron Blood, and a subsequent transfusion of artificial blood from the original Human Torch. As Spitfire, she possesses the ability to run at lightning-fast speeds, with reflexes, reactions, coordination, agility, and endurance to match. When she runs, a trail of non-damaging fire appears behind her. She can create cyclones by running in circles, and can run up walls and across water. Her skin is also hardened to withstand the rigors of such speed, providing a type of body armor, and her costume is synthetic stretch fabric chemically treated for protection from friction and other hazards of superhuman speed.