In 2004, Follows was part of the ensemble cast of the Hallmark movie "Plainsong", which included Aidan Quinn, Rachel Griffiths, and America Ferrera. In 2009, she made a guest appearance on "Brothers and Sisters". In 2011, she had a guest role on "House". In 2012, she played Beth in "Hollywood Heights". Also in 2012 she appeared as Alice Stewart in one episode of "Longmire", and in the Starz series "World Without End", playing Lady Maud. In 2013, Follows was cast as Catherine de' Medici on "Reign", a historical drama series on The CW, based on the early life of Mary, Queen of Scots. The series ran for four seasons.