At the end of the arterial in eastern Schenectady, NY 7 becomes the at-grade Troy–Schenectady Road as it heads along the south bank of the Mohawk River into Albany County. Shortly after entering the county and the Town of Colonie, NY 7 leaves the river and progresses southeast toward the hamlet of Latham. Soon after passing the Albany International Airport and prior to entering the center of Latham, NY 7 meets I-87 (the Adirondack Northway) at exit 6. Here, NY 7 joins the Adirondack Northway northward while Troy–Schenectady Road continues east as NY 2. At exit 7, NY 7 separates from the Adirondack Northway and continues east on a five-lane, limited-access freeway known locally as "Alternate Route 7". The route connects to US 9 and I-787 / NY 787 by way of interchanges prior to crossing over the Hudson River and into Troy over the Collar City Bridge. The route remains a limited-access highway to 8th Street, where it becomes the at-grade Hoosick Street.