Quintero made his first appearance in the 2015–16 CONCACAF Champions League on 5 August 2015 in a 4–0 victory over C.D. Motagua in the opening match of the group stage. He picked up his first and second goal of the tournament on September 16, scoring twice in a 3–1 win against C.D. Walter Ferretti. In the first leg of the quarterfinal matchup with Seattle Sounders, Quintero scored once to help América secure a 2 all draw. In the second leg Quintero found the back of the net in the 42nd minute to level the aggregate score at 3. América would score two more goals to advance past the Sounders. América would advance past Santos Laguna 1–0 in extra time to set up a final against Tigres UANL. Although he did not feature in the first leg, Quintero returned to the starting lineup for leg two, as "Las Águilas" won their second consecutive CCL title.