Bob Layton and Jackson Guice wrote and illustrated, respectively, the first few issues of "X-Factor". They soon turned over creative duties to Louise Simonson (writer) and Walt Simonson (artist). Despite their relationship as husband and wife, both the Simonsons have said they did not approach work with each other any differently than any other collaboration; in particular, though Walt occasionally contributed ideas, he did not co-plot the series with his wife. In "X-Factor" #6 (1986), Louise introduced Apocalypse, who would appear in multiple issues and become X-Factor's nemesis.