He is notable for being the first Japanese player to play for a Major League Baseball team. Sent over to the United States by the Nankai Hawks, Murakami saw success as a reliever for the San Francisco Giants, debuting at the age of 20 in . In , he struck out over one batter per inning pitched, posted an ERA under 4 and earned eight saves. Following this season, however, Murakami headed back to his original Japanese club due to contractual obligations, where his success continued for another 17 years.