US 50 has received numerous upgrades during its existence in Maryland, including the construction of the John Hanson Highway, which is also the unsigned Interstate 595 (I-595), its extension onto the Eastern Shore and replacement of US 213 due to the construction of the Chesapeake Bay Bridge, and the full conversion of the eastern segment of the route into a four-lane divided highway. Many of the older alignments of US 50 are still part of the Maryland and US highway systems, such as US 50 Business (US 50 Bus.) in Salisbury. US 50 continues to be upgraded on the Eastern Shore.