Since 1984, Takamine served as the State Representative for the Big Island's 1st District until 2007 when he was elected as the State Senator for District 1. During one campaign he "went to bat" at the century-old local Kalanianaole Elementary and Middle School located on the Hamakua Coast. With the demise of the jobs of the sugar-cane industry, the school had declined when Takamine stepped in and revived interest. His roles in the legislature as a Representative have included serving as Chair of several committees, notably the Finance Committee from 1998-2006. He was deposed from this position on the Finance Committee during pre-2007-session faction fighting in the Democratic caucus. During the 2006 campaign, Takamine had co-hosted an official Akaka campaign rally at the Honokaa ranch of Larry Mehau. Takamine and numerous other Democratic elected officials and candidates were photographed there by Hawai'i Free Press photojournalists.