In January 2013, Altmire began work as a lobbyist and public relations executive for the health insurance company Florida Blue. During his time there, he worked to implement of the Affordable Care Act in Florida. In 2015, he was appointed chairman of the Florida Blue Foundation, the philanthropy associated with Florida's Blue Cross Blue Shield Company. In August 2017, he left the company in order to promote his book, "Dead Center: How Political Polarization Divided America And What We Can Do About It". In February 2019, Altmire was named a senior advisor to the health care consulting firm Avalere Health.