Proceeding north through West Seneca, NY 240 proceeds north, crossing an intersection with CR 534 (Mineral Springs Road). At this junction, the residential street turns over to commercial as NY 240 crosses over Buffalo Creek just west of the mouth of Cayuga Creek. After crossing over Buffalo Creek, NY 240 enters the town of Cheektowaga. In Cheektowaga, NY 240 immediately intersects with NY 354 (Clinton Street) before bending northeast around exit 53 of the Thruway. Just northeast of exit 53, NY 240 crosses under the Thruway mainline, intersecting with the western terminus of CR 315 (Dingens Street).