May and the alternative Spiders later travel to Earth-616, where they recruit its version of Peter Parker alongside his most recent partner Silk and his clone Kaine. May reveals her identity to Peter, revealing that they have met before earlier in his timeline (when she travelled back in time to the events of ASM Vol. 1 #25). The Spiders take the three to a safe zone where they eventually also come into contact with a team led by the "Superior Spider-Man" Otto Octavius. When Peter and Octavius clash and do battle with each other, Mayday requests that Captain Universe Spider-Man intervene and stop the fighting, as better time and energy could be spent tracking down the Inheritors, but the Cosmic Spider refuses. Peter eventually wins the fight. The safe zone is then compromised by The Inheritors, led by their father Solus, Cosmic Spider is killed, May is easily defeated, and can only look on helplessly as Baby Benjy is captured, and it is revealed that he is "The Scion", a vital part of a prophecy that also involves "The Other" (Kaine) and "The Bride" (Silk) Despite her earlier vow to kill the Inheritors, after seeing Otto kill the Inheritors' 'Master Weaver' to stop their plans for good, May reconsiders her stance, avoiding destroying a crystal containing the life-essence of the Inheritors' 'father'. With the crisis concluded, Spider-Ham assures May that, if her father was anything like him, he would be proud of what she just did, May accepting the compliment despite Spider-Ham's comical appearance. Returning to her world with the Ben Parker of Earth-3145—a world where Ben became Spider-Man and his family were killed, resulting in Earth being decimated by a nuclear apocalypse—May learns that her mother and Wes survived the Inheritors' attack, although her father gave his life to save them. With Ben deciding to remain on this world to be the grandfather no other Ben Parker had the chance to become, May, on her mother's encouragement, decides to don her father's costume to become Spider-"Woman".