Houtteman continued his successful season in the second half. On August 19, he faced the Browns and pitched a one-hitter, and faced the minimum 27 batters in the process. Houtteman ended the season just short of Ted Gray's prediction of 20 victories, and finished the season with a 19–12 record. He led the league in shutouts with four and was second in games started with 34, second in innings pitched with 274.2, third in wins, and third in complete games with 21. His ERA of 3.54 was good for fifth in the American League. He also earned six points in MVP voting, and finished tied for 24th. On October 2, the day after the 1950 season ended, Houtteman married Shelagh Marie Kelly. They met in New York's Catskill Mountains at Grossinger's Resort.