"Jeffers" sailed from Norfolk 8 June with Task Force 65 (TF 65) and arrived Oran, Algeria, on 22 June. While preparing for the giant assault on Sicily, she patrolled off other African ports, shooting down a German bomber during 6 July "Luftwaffe" raid on Bizerte. "Jeffers" sailed two days later with Rear Admiral John Hall's force for Gela; and, upon arrival 9 July, she guarded the transports. Early next day the great assault began, with "Jeffers" assigned the task of shooting out shore searchlights and providing fire support for the Amphibious Battle of Gela. As the landing proceeded with great success in the following days, the ship fired support missions and served on antisubmarine patrol. She sailed to Bizerte on 18 July, but was back at Palermo on 31 July with cargo ships. "Jeffers" sailed to Oran the next day, and from that port continued to New York, arriving on 22 August.