The city's inhabitants included many Calvinists, and in 1562 and 1567 it was the scene of struggles between them and the supporters of the Catholic Church. In 1576 and 1588 Henri III, king of France, chose Blois as the meeting-place of the States-General, and in 1588 he brought about the murders of Henry, duke of Guise, and his brother, Louis, archbishop of Reims and cardinal, in the Château, where their deaths were shortly followed by that of the queen-mother, Catherine de' Medici. From 1617 to 1619 Marie de' Medici, wife of King Henri IV, exiled from the court, lived at the château, which was soon afterwards given by King Louis XIII to his brother Gaston, Duke of Orléans, who lived there till his death in 1660.