The game follows both protagonists of the series: Edward Elric and his younger brother, Alphonse, as their explore lands full of giant creatures known as chimeras as well as thieves. Once meeting a girl named Armony, the two brothers start learning where the chimeras come from. The player primarily controls Edward, an alchemist who can transform objects from the game's stages into weapons to defeat his enemies. Additionally, he can receive support by Alphonse's AI in order to fight multiple enemies.