Wells saw his first NFL regular season playing time on special teams on November 21, 2004, in Houston. He was named the starting center in the spring of 2006, and held that position until 2011, missing just one game because of an eye injury. In November 2006, Scott was given a 5-year, $15 million contract extension. At the end of the 2010 season, Wells and the Packers appeared in Super Bowl XLV. He was a starter in the 31–25 victory over the Pittsburgh Steelers. On December 26, 2011, Wells was voted to his first career Pro Bowl.