Political progressivism varied across the state. Los Angeles (population 102,000 in 1900) focused on the dangers posed by the Southern Pacific Railroad, the liquor trade, and labor unions; San Francisco (population 342,000 in 1900) was confronted with a corrupt union-backed political "machine" that was finally overthrown following the earthquake of 1906. Smaller cities like San Jose (which had a population of 22,000 in 1900) had somewhat different concerns, such as fruit cooperatives, urban development, rival rural economies, and Asian labor. San Diego (population 18,000 in 1900) had both the Southern Pacific and a corrupt machine.