Scorpia appears as a member of a female incarnation of the Sinister Syndicate. She states to Francine Frye that she heard about her frying the original Electro and stealing his schtick. The Sinister Syndicate begins their mission where they attack the F.E.A.S.T. building that Boomerang is volunteering at. Beetle leads the Sinister Syndicate in attacking Boomerang. It was stated by Boomerang that he was the one who came up with the Sinister Syndicate name. After getting Aunt May to safety, Peter Parker changes into Spider-Man and helps Boomerang fight the Syndicate. The Syndicate starts doing their formation attack until Spider-Man accidentally sets off Boomerang's gaserang which knocks out Spider-Man enough for the Syndicate to make off with Boomerang. As Beetle has Electro write a proposal on how the Syndicate can use Boomerang as an example to the criminal underworld, Beetle leaves while calling Wilson Fisk that they caught Boomerang as she is given the information on where the exchange can happen. Scorpia later mentioned to the Syndicate members that Rhino once refused to arm wrestle her. When Beetle returns to the headquarters, Scorpia is present when Mayor Wilson Fisk brings the full force of New York City to their headquarters demanding that they surrender Boomerang to him. The Syndicate then assists Spider-Man against Mayor Fisk's forces. After Spider-Man evacuates Boomerang, the Syndicate fights Mayor Fisk's forces while not killing them. The Syndicate is defeated and arrested by the police. Their transport is then attacked by an unknown assailant who frees them.