During a counter narcotics deployment to the Caribbean, 4 April–20 June 2005, "Doyle", and "Cutlass 463", her embarked Sikorsky SH-60B Seahawk of Helicopter Antisubmarine Squadron (Light) (HSL) 46 Detachment 3, pursued fishing vessel "Dos Continentes", suspected of smuggling cocaine, north of the Panamanian/Colombian coast, 3 May. The smugglers set their boat ablaze and jumped overboard. "Doyle" launched "Cutlass 463" and made for the scene at flank speed. She lowered a rigid hull inflatable boat (RHIB) that rescued four of the smugglers, and battled the fire for several hours until they extinguished the flames during the mid watch. The ship's damage control sailors, reinforced by Coast Guard law enforcement agents, boarded "Dos Continentes" and recovered several packages containing 150 pounds of cocaine from the hulk. "Doyle" prevented an estimated 13 tons of cocaine from entering the United States during this interception, and the U.S. later sank the vessel to prevent her from becoming a hazard to navigation. The frigate made a total of five interdictions during her deployment that led to the apprehension of 28 narco-terrorists, and the seizure or destruction of an estimated $315 million worth of cocaine (83 bales during the first month alone).