KYOU-DT2, branded on-air as KYOU NBC 15.2, is the NBC-affiliated second digital subchannel of KYOU-TV, broadcasting a 720p high definition signal (downconverted from the native 1080i resolution of the NBC network, to accommodate for all the remaining subchannels) on virtual and UHF digital channel 15.2; however, a direct-to-cable full 1080i high definition feed of this subchannel is available on select cable providers. On cable, KYOU-DT2 is available on Mediacom digital channel 16 or 103 in standard definition and channel 816 in Full HD in Ottumwa, and Cable One channel 41 in standard definition and channel 1041 in Full HD in Kirksville.