After the 1930 season, the Tanks folded. In 1931, Presnell joined the Portsmouth Spartans in the NFL. He remained with Portsmouth from 1931 to 1933. He had his best season in 1933, when he led the NFL in total offense with 1,296 yards. He also broke the single-season NFL scoring record with 64 points. (Ken Strong tied with Presnell with the same point total in 1933.) During the 1933 NFL season, Presnell completed 50 of 125 passes for 774 passing yards and added 522 rushing yards on 118 carries for an average of 4.4 yards per carry. He also kicked five field goals and 13 extra points. He led the NFL with six rushing touchdowns and 13 successful extra point conversions. He also finished second in the league (behind Harry Newman) in passing touchdowns, passes completed, pass attempts, and passing yards. Following the 1933 season, Presnell was selected as a first-team All-NFL player by the NFL, the United Press, and Collyers Eye Magazine.