While in Egypt, Antony had been engaged in an affair with Cleopatra and had fathered twin children with her. Aware of his deteriorating relationship with Octavian, Antony left Cleopatra; he sailed to Italy in 40 BC with a large force to oppose Octavian, laying siege to Brundisium. This new conflict proved untenable for both Octavian and Antony, however. Their centurions, who had become important figures politically, refused to fight due to their Caesarian cause, while the legions under their command followed suit. Meanwhile, in Sicyon, Antony's wife Fulvia died of a sudden illness while Antony was en route to meet her. Fulvia's death and the mutiny of their centurions allowed the two remaining triumvirs to effect a reconciliation.