Past the Memphis city limits in the suburb of Bartlett, U.S. 64 separates from U.S. 70/79, taking a more southerly routing through the state. U.S. 70 and US 79, meanwhile, head to the northeast, paralleling I-40 to Brownsville. East of the city, U.S. 79 breaks from U.S. 70, following U.S. 70 Alternate out of the city to the northeast. U.S. 70, now concurrent with only its unsigned designation of State Route 1, heads east, interchanging with I-40 at exit 66 before entering Jackson. The route continues northeast from the city, meeting I-40 once more at exit 87 just outside the city limits. At Huntingdon, U.S. 70 Alternate rejoins US 70 as the main route turns to the east toward New Johnsonville, where it crosses the Tennessee River.