In Week 3 of the 2015 season, Green caught 10 passes for a career-high 227 yards and two fourth quarter touchdowns in a 28–24 win over the Baltimore Ravens. His 227 yards was the second highest single game total in franchise history, trailing only Chad Johnson's 260 receiving yards in a 2006 game against the San Diego Chargers. In Week 8, against the Pittsburgh Steelers, he had 11 receptions for 118 receiving yards and a touchdown in the 16–10 victory. In Week 12, against the St. Louis Rams, he recorded his second multi-touchdown game of the season. In Week 13 against the Cleveland Browns and Week 14 against the Steelers, he recorded consecutive games going over 100 receiving yards while recording a receiving touchdown. He finished the 2015 season with 86 receptions, 1,297 yards, and ten touchdowns.