The city is served by numerous highways, with Pennsylvania Route 18 and U.S. Route 422 being the major routes running through the city, while Interstate 376 passes to the west of the city. Two more major routes — Pennsylvania Route 65 and U.S. Route 224 — terminate in the city. Pennsylvania Route 108 and Pennsylvania Route 168 also run through the city. U.S. 422 Business, a former alignment of U.S. 422, runs through the city, ending on each side of the city when the main 422 leaves the New Castle Bypass. I-376 and U.S. 422 are briefly concurrent with each other on the New Castle Bypass, though south of New Castle until Chippewa Township near Beaver Falls, I-376 is tolled by the Pennsylvania Turnpike Commission. The city is located west of Interstate 79, south of Interstate 80, and north of Interstate 76, the Pennsylvania Turnpike.