He has made many guest appearances on television series, including recurring roles on "Dream Street", "Law & Order" and "Miami Vice". In 2012, he guest-starred in the "Blue Bloods" episode "Domestic Disturbance", playing Lieutenant Martin Perez. (He reprised the role in the 2016 "Blue Bloods" episode "Back in the Day".) Calderón worked on two films in 2012: "West End", directed by Joe Basille; and "Biodegradable", a futuristic film shot in the Dominican Republic with an all Latino cast, directed by Juan Basanta. In 2014, he played Arquimedes, the bodyguard of Enoch "Nucky" Thompson in seven episodes of the fifth (final) season of the HBO series "Boardwalk Empire". He played Alejandro, a recurring role on "Fear the Walking Dead". Since 2017, he has appeared as Detective Santiago "Jimmy" Robertson on the Amazon TV series, "Bosch".