On April 11, 2018, Andrus was hit by a pitch on his right arm and left the game. X-rays and CT scans tested positive that Andrus had suffered a fractured right elbow. As a result, he was placed on the disabled list for the first time of his Major League career. No surgery was required, but to keep out of baseball activity for 6-8 weeks. He was activated on June 18 from the disabled list. Andrus finished 2018 hitting .256/.308/.367/.675 with 6 home runs and 33 RBI.