One important qualification to habitability criteria is that only a tiny portion of a planet is required to support life. Astrobiologists often concern themselves with "micro-environments", noting that "we lack a fundamental understanding of how evolutionary forces, such as mutation, selection, and genetic drift, operate in micro-organisms that act on and respond to changing micro-environments." Extremophiles are Earth organisms that live in niche environments under severe conditions generally considered to life. Usually (although not always) unicellular, extremophiles include acutely alkaliphilic and acidophilic organisms and others that can survive water temperatures above 100 °C in hydrothermal vents.