Miaphysitism holds that in the one person of Jesus Christ, divinity and humanity are united in one (μία, "mia") nature (φύσις - "physis") without separation, without confusion, without alteration and without mixing where Christ is consubstantial with God the Father. Around 500 bishops within the patriarchates of Alexandria, Antioch and Jerusalem refused to accept the dyophysitism (two natures) doctrine decreed by the Council of Chalcedon in 451, an incident that resulted in the second major split in the main body of the State church of the Roman Empire.