Harkins was appointed House Majority Whip by former Speaker of the House Thomas Finneran in 2001. Before her appointment, she served as the Assistant Majority Whip and the House Chairman of the Joint Committee on Education Arts and Humanities. Harkins has also served as the Chairman of the House Committee on Science and Technology, the House Chairman of the Joint Committee on Housing and Urban Development, Vice-Chairman of the Committee on Commerce and Labor, Co-Chairman of the bi-partisan Women’s Caucus and as a member of the Committee on Ways and Means, and Public Safety. She has also chaired the Special Education Study Commission created in the 1997 state budget and the Special Commission that reformed and restructured the School Building Assistance Program.