The in mice, which is used as a possible indicator of snake venom toxicity, is: 0.133 mg/kg intravenous, 0.40 mg/kg intraperitoneal, about 0.75 mg/kg subcutaneous. For most humans, a lethal dose is about 40–70 mg. In general, the toxicity depends on a combination of five different venom fractions, each of which is less toxic when tested separately. Venom toxicity and bite symptoms in humans vary within different populations and over time. In another study by Meier and Theakston revealed that the lethality of venom of Russell viper varies with change in route of injection as their results predicts the of 0.4 mg/kg through Intraparietal (I.P) route, 0.75 mg/kg/subcutaneous (S.C) route and 0.3 mg/kg through intravenous (I.V) route.