In January 2018, Soubry said the government should not let the 35 MPs she described as "hard Brexiteers" dictate the terms of Brexit. On 15 April 2018, Soubry attended the launch event of the People's Vote, a campaign group calling for a public vote on the final Brexit deal between the UK and the European Union. Later that year, Soubry declared that there should be a national government to solve the issue of Brexit and went on to argue that members of the European Research Group should be expelled from the Conservative Party. In December 2018, she declared that she would resign the Conservative whip and vote to have no confidence in her government if 'no deal' became the policy of the government.