Quintero opened the 2010–11 season in strong form, scoring once and assisting three times in the first three games of the Apertura. He then entered a patch of bad form, failing to score and only picking up one assist the rest of the season. Despite Quintero's struggles, Santos still managed to qualify for Liguilla, where Quintero came alive. After a quiet quarterfinals against Chiapas, Quintero scored 3 times over two legs to help Santos advance past Club América by an aggregate score of 5–4. He would score again against Monterrey to give Santos a 3–2 win in the first leg of the final, but Rayados would win the return leg 3–0 to take the championship. Quintero started the Clausura strong, picking up one goal and one assist in the opening match, a 2–1 win over Atlante. He would find the back of the net for the second time of the season in matchweek 4 in a 2–1 victory against Chiapas. On 2 April Quintero scored once and recorded an assist in a 3–0 win against Cruz Azul. Quintero was sent off in the 71st minute after headbutting Christian Giménez. Quintero alleged that had Giménez pushed him after another Cruz Azul player, Rogelio Chávez, had called Quintero an "ape", sparking his reaction. While Chávez admitted to a verbal altercation with Quintero denied using any racist insults. Quintero received a 6 match suspension after the incident, three matches for violent conduct and than another three matches for further aggression towards an opponent after being sent off. The suspension was later reduced to four matches. He returned from his suspension on 29 April against Estudiantes Tecos, picking up an assist in the 3–1 victory. Quintero had 3 goals and 3 assists in the Clausura, however Santos failed to qualify for Liguilla. Quintero made his first appearance of the 2010–11 CONCACAF Champions League on August 4, 2010, scoring one in a 5–0 win over San Juan Jabloteh F.C. to help give Santos a 6–0 win on aggregate. He scored twice in four appearances in the group stage as "Los Guerreros" advanced to the quarterfinals, where they lost to Cruz Azul by an aggregate score of 5–1.