Flight 781 departed from Rome at 10:31 CET (09:31 UTC) on 10 January 1954, bound for the final stage of its flight to London. At about 10:50 CEST, a BOAC Argonaut, registration G-ALHJ, piloted by Captain Johnson, which was flying the same route at a lower altitude, was in contact with Captain Gibson. During a radio communication about weather conditions, the conversation was abruptly cut off. The last words heard from Gibson were "George How Jig, from George Yoke Peter, did you get my—". Soon afterwards, witnesses saw wreckage falling into the sea.