The sixteenth season episode of "Family Guy", "Dog Bites Bear" (the 300th episode overall) sees Stewie and Brian sing the Boyz II Men version of the song at the funeral of Stewie's teddy bear Rupert, which is held in the mountains of Vermont. As they head home late at night, as Stewie is asleep in the car and Brian stops at a vintage toy store to buy a replacement Rupert for him, the Boyz II Men version of the song plays, closing out the episode.