At his new team, Nikopolidis also earned a reputation for making game-winning saves in the most important games. Displaying his penalty-saving abilities, Nikopolidis saved three penalty kicks against Roma, Real Madrid, and Rosenborg BK, making him undefeated from the penalty spot in UEFA Champions League football in the Olympiacos shirt. In the 2007–08 season, he also equaled the Greek league record for the most penalty kicks saved in one season, which included saves against PAOK and former club Panathinaikos. Nikopolidis announced his plans to retire at the end of the 2009–10 season.