"Makes Me Wonder" was released as the lead single from the album on March 27, 2007. It became the band's first number-one on the "Billboard" Hot 100 and "Billboard" Dance Club Songs charts. The song won the Grammy Award for Best Pop Performance by a Duo or Group with Vocal at the 50th Grammy Awards, their second song to win the award. The song was among the most successful of 2007, and was their biggest hit until the release of "Moves like Jagger" by the band in 2011. It also reached number one in Canada and Hungary.