Ortiz Cofer's work can largely be classified as creative nonfiction. Her narrative self is strongly influenced by oral storytelling, which was inspired by her grandmother, an able storyteller in the tradition of teaching through storytelling among Puerto Rican women. Ortiz Cofer's autobiographical work often focuses on her attempts at negotiating her life between two cultures, American and Puerto Rican, and how this process informs her sensibilities as a writer. Her work also explores such subjects as racism and sexism in American culture, machismo and female empowerment in Puerto Rican culture, and the challenges diasporic immigrants face in a new culture. Among Ortiz Cofer's more well known essays are "The Story of My Body" and "The Myth of the Latin Woman," both reprinted in "The Latin Deli".