Refounded in 1760 by Christian settlers from adjoining areas, they chose it as their new home due to its proximity to the Axios River, near the ruins of ancient town Atalanti. The town form part of the Ottoman Empire until the early 20th century. In the Greek revolution of 1821, inhabitants of Axioupolis and other villages, fought against Ottomans. The family of Papazafiriou Stamatiadi from Idomeni gave the most famous Greek fighters of 1821. The Ottoman troops defeated the rebels in the area, and the revolution continued only in Southern Greece.