Chithra has sung more than 25,000 songs in number of Indian languages. But predominately she works in South Indian film industry. Chithra has the fame of working with huge number of music directors across India. She has recorded maximum number of songs to the music directors like A. R. Rahman, Ilayaraja, M. M. Keeravani, Koti, S. V. Krishna Reddy, Hamsalekha, Raveendran, Johnson, Sharreth, S. A. Rajkumar, Manisharma, Vidyasagar, Deva, Devi Sri Prasad, Mickey J Meyer in Malayalam, Telugu, Tamil and Kannada. She has worked with Laxmikant–Pyarelal, Anu Malik, Anand-Milind, Rajesh Roshan, Jatin-Lalit, Pritam, Sandesh Shandilya, Nadeem-Shravan, Nikhil-Vinay, Dilip Sen-Sameer Sen, Anand Raaj Anand, Shankar Ehsaan Loy, Shantanu Moitra and A. R. Rehman in Hindi.