In 1922, he joined forces with his brother Henry, who had also moved to Portland. Together over the next few years they incorporated four businesses, including Mybros Meat Market, Oregon Piggly Wiggly, Pioneer Market Company (which leased space to vendors), and Mybros Inc., all in downtown Portland. Differences of opinion between the brothers led to Henry's departure from the partnership, and over time, Meyer expanded Mybros into the Fred Meyer chain of supermarkets and department stores. A "self-service drugstore" that Meyer opened in 1928 in downtown Portland was considered the first of its kind in the nation.