SR 25 heads west from its southern terminus at an interchange with I–75 in rural Wood County. The highway heads west, before turning north at an intersection with Cygnet Road (Township Highway 3). The highway heads northeast passing through farmland as a two-lane highway closely paralleling I–75. The route turns due north and becomes a four-lane divided highway, still closely paralleling I–75, before I–75 heads northeast. The road has an intersection with SR 281 and then begins to enter residential properties. The highway enters Bowling Green at an interchange with U.S. Route 6 (US 6) and passes through commercial properties.