The day after giving birth to her second son, Mealing was diagnosed with breast cancer. Mealing was asked to be an ambassador for Breast Cancer Care in early 2010. She has developed a close bond with the charity. "When I was diagnosed the first leaflet I received was from Breast Cancer Care. They have been there for me ever since. I am deeply honoured to be given a chance to give something back to them." After losing a close friend to breast cancer early the same year Amanda decided to dedicate a JustGiving page to raise money in memory of her friend. She ran the 2012 London Marathon on her 45th birthday for Breast Cancer Care.