During the fall of the Western Roman Empire, Lanciano was sacked by the Goths, and was destroyed during the Lombard invasion (c. 571 AD). A new settlement was then created around a castle built by the new rulers. In 610, however, it was conquered by the Byzantines, who annexed it to the Duchy of "Teate" (Chieti) and allowed the trades to restart. In the late 8th century Lanciano was conquered by the Franks, who included it in the Duchy of Spoleto.