Reynolds is thought to have been born in Tallulah, Louisiana in 1904, although his death certificate states his birthplace as Arkansas in 1900. He was blinded by a shotgun blast to the face in Louisiana in the mid-late 1920s, which resulted in the physical loss of his eyes. Despite this handicap, Blind Joe became known for his distinctive bottleneck style as well as his reported accuracy with a pistol, with which it is said he could judge the position of a target by sound alone.