Woolfolk played seven seasons in the NFL. As a rookie in 1982, he finished third in the NFL in all-purpose yards. And in 1983, he set an NFL record with 43 rushing attempts in a single game. He was also fifth in the NFL in receptions in 1985. Woolfolk was plagued with injuries during his NFL career and was able to play in 16 games only twice—in 1983 and 1985. In both of those years, he accumulated at least 1,200 yards from scrimmage. He also had seven 100-yard games—five receiving and two rushing.