Keeble served on the Agriculture Select Committee (before its abolition in 2001), and became Parliamentary Private Secretary to Rt. Hon Hilary Armstrong in 1999. After the 2001 general election she was appointed Parliamentary Under Secretary of State at the Department of Transport, Local Government and the Regions, where her responsibilities included planning, regeneration, housing and local transport. She chaired the taskforce on parks and urban green spaces. In 2002, she moved to the Department for International Development. In 2003, she left the frontbench. From 2005, she was a member of the Treasury Select Committee.