SR 207 was assigned in 1962. Running along the majority of SR 207's present path, excepting the southernmost portion of the highway between US 23 and SR 104, along with the SR 104 concurrency, the designation replaced the entirety of what was SR 277 prior to that year. The change was necessitated by the coming of the Interstate Highway System to Ohio, which included construction of Interstate 277 in the Akron vicinity. Ohio follows a standard that no route number can be duplicated between different types of state highways, so SR 277 became SR 207.