In January 2016, the Center released a report entitled Seeing Red - Time for Action on Food Dyes which criticized the continued use of artificial food coloring in the United States. The report estimated that over half a million children in the United States suffer adverse behavioral reactions as a result of ingesting food dyes, with an estimated cost exceeding $5 billion per year, citing data from the Centers for Disease Control and Prevention. The report urges the Food and Drug Administration to take action to ban or curtail the use of such dyes. CSPI has urged companies to replace synthetic colorings with natural ones, and Mars, General Mills, and other major food manufacturers have begun doing so.