Shortly after the Scarlet Witch's insanity seemingly killed Hawkeye, and again disbanded the Avengers, Natasha, weary of espionage and adventure, travelled to Arizona but was targeted. Andrea discovers that other women had been trained in the Black Widow Program, and all are now being hunted down and killed by the North Institute on behalf of the corporation Gynacon. Natasha's investigations led her back to Russia, where she was appalled to learn the previously unimagined extent of her past manipulation, and she discovered the Widows were being hunted because Gynacon, having purchased Russian biotechnology from Red Room's successor agency 2R, wanted all prior users of the technology dead. Natasha finds and kills the mastermind of the Black Widow murders: Ian McMasters, Gynacon's aging CEO, who intended to use part of their genetic structure to create a new chemical weapon. After killing McMasters, she clashed with operatives of multiple governments to help Sally Anne Carter, a girl Natasha had befriended in her investigations, whom she rescued with help from Daredevil and Yelena Belova. She soon returned the favor for Daredevil by reluctantly working with Elektra Natchios to protect his new wife, Milla Donovan, from the FBI and others, although Yelena proved beyond help when she agreed to be transformed into the new Super-Adaptoid by A.I.M. and HYDRA.