After moving back to the UK in the early 2000s, Donohoe took the role of DI Susan Alembic in the crime drama "Murder City" (2004–2006). In 2009 she joined the cast of ITV soap opera "Emmerdale" as businesswoman Natasha Wylde. Donohoe played the character until leaving the series in November 2010. On 18 and 19 February 2010, she was a guest panellist on "Loose Women". She has also lent her voice to the Activision PC video game "Santa Fe Mysteries: The Elk Moon Murder" as Karen Gordon.