After passing over the Pocomoke River, US 50 enters Worcester County and runs through more wooded areas before coming to an intersection with MD 610, which heads north to Whaleyville. Following this, the road curves to the southeast and passes through a mix of farmland and woodland. The route comes to an eastbound exit and westbound entrance with the western terminus of MD 90, a two-lane expressway that provides access to the northern part of Ocean City. From here, US 50 continues through rural land and heads into open agricultural areas as it reaches a junction with MD 346. Past this junction, MD 346 runs closely parallel to the southwest of the route until the intersection with Caleb Road (MD 992F), where MD 346 curves to the south-southeast toward Berlin. US 50 runs through a mix of farmland and woodland as it passes to the north of Berlin. The road comes to an intersection with MD 818, which provides access to Berlin. A short distance later, US 50 comes to a grade crossing with the Maryland and Delaware Railroad's Snow Hill Line as it reaches a cloverleaf interchange with US 113, with the ramps from eastbound US 50 to southbound US 113 and from southbound US 113 to westbound US 50 also crossing the railroad tracks at-grade.