In the second Apokoliptian invasion of Earth 2, Lois and Kara are reunited, after Kara and Huntress return to Earth 2 from Prime Earth. Lois, along with Kara, Val, Huntress, Batman and other heroes, fights against the armies of Apokolips and new villains appearing across Earth 2. While searching for Huntress beneath the fire pits of Earth 2 in DeSaad's cloning facility, Lois, Val, Kara and Batman found the real Superman who has been held captive for five years. He was revived by DeSaad and was used as the genetic source for the Kryptonian clones. The extraction of his DNA corrupted his body leaving him without any powers. Lois and Superman reunite briefly, before he sacrificed himself one last time, destroying the Parademon facilities using his corrupt DNA. After Superman's death, Lois gave Kara the symbol from his uniform, which was then worn by Kara in remembrance.