After a stint as professor at Aligarh Muslim University and later at University of Calcutta, he became editor of "Hindustan Times" in 1925. Later, he was appointed Secretary to the Chamber of Princes, whence he moved to Patiala State and then to Bikaner State as Foreign Minister and later became the latter's Prime Minister. When India achieved political independence, Sardar Madhava Panikkar represented the country at the 1947 session of the UN General Assembly. In 1950, he was appointed Ambassador of India (the first non-Socialist country to recognise People's Republic of China) to China. After a successful tenure there, he went as Ambassador to Egypt in 1952. He was appointed a member of the States Reorganisation Commission set up in 1953. He was also India's Ambassador to France and a member of Rajya Sabha, the upper house of the Indian parliament. He also served as Vice-Chancellor of the University of Kashmir and the University of Mysore.