In 1568, Crichton, along with Bothwell's other estates, was granted to Francis Stewart, son of John Stewart and Jean Hepburn, and thus bastard grandson of James V. Francis was created Earl of Bothwell in 1577 and married Margaret Douglas. He travelled in Europe, and he designed the very modern Italianate north range in the 1580s. James VI was at Crichton on 17 March 1587, planning an embassy to Denmark with Peter Young. Bothwell lost the king's favour and was accused of witchcraft and forfeited his estates in 1592. He was eventually forced to flee to Naples where he died. His son Francis Stewart was reinstated, but laboured under his father's debts, and sold Crichton to the Hepburns of Humbie.