Quintero made his first appearance of the 2015–16 season on 26 July, scoring once in a 4–2 defeat to Puebla in the opening game of the 2015 Apertura. Quintero scored again on 11 August to help América to a 4–0 win over Dorados de Sinaloa. On 1 November he scored once and assisted another as "Las Águilas" defeated Toluca 3–2. Quintero ended the Apertura with 4 goals and 3 assists. In the quarterfinals of Liguilla, América advanced past Club León 5–3 on aggregate. After losing the first leg of the semifinals 3–0 to Pumas UNAM, Quintero scored two early goals in the second leg to bring América back into the fixture. Although they would win the second leg 3–1, Pumas advanced on aggregate 4–3.