From June 4, 1812 until August 10, 1821 the area that would become Kansas Territory 33 years later was part of the Missouri Territory. When Missouri was granted statehood in 1821 the area became unorganized territory and contained few if any permanent white settlers, except Fort Leavenworth. The Fort was established in 1827 by Henry Leavenworth with the 3rd U.S Infantry from St. Louis, Missouri; it is the first permanent European settlement in Kansas. The fort was established as the westernmost outpost of the American military to protect trade along the Santa Fe Trail from Native Americans. The trade came from the East, by land using the Boone's Lick Road, or by water via the Missouri River. This area, called the Boonslick, was located due east in west-central Missouri and was settled by Upland Southerners from Virginia, Kentucky, and Tennessee as early as 1812. Its slave-owning population would contrast with settlers from New England who would eventually arrive in the 1850s.