Passing General Motors Tonawanda Engine Plant, NY 266 is now known as River Road, crossing over I-190 and providing a ramp to the roadway. Just north of the ramp, the route comes to an intersection with the western end of NY 325 (Sheridan Drive). Passing a plant for Dunlop Rubber, NY 266 runs along the shores of the Niagara River through Tonawanda, passing multiple factories as well as the Huntley Generating Station as it bends northward along the shore. Crossing an intersection with County Route 189 (CR 189 or Grand Island Boulevard), NY 266 crosses under the South Grand Island Bridge, used by I-190 and NY 324. On the other side of a bridge, NY 266 connects to the roadway at exit 17.