His Wyandot connections and bilingual abilities served Zane well. He later served as a guide to the Commissioners of the Northwest Territory during their treaty conferences with the Native Americans. Zane purchased from the federal government at the site of Zanesfield in about 1795. In return for his service to the United States, in 1802, the United States Congress granted Isaac Zane three tracts totalling in Champaign County, Ohio (see Zane's Tracts#Isaac Zane Tracts). In 1803, he was elected as one of the first trustees of Jefferson Township. Isaac Zane died in 1816, and was buried near Zanesfield.