Sreesanth was selected for his first Test squad in the home series against England in March 2006, in place of Zaheer Khan. He claimed 4/95 in his debut appearance in the 1st Test in Nagpur, where he opened the bowling with Irfan Pathan. He was ruled out of the second Test in Mohali due to illness, but recovered and captured five wickets as well a 29* with the bat in the Third Test in Mumbai. With the axing of Pathan, Sreesanth became India's leading pace bowler on the tour of the West Indies. He missed the second Test due to an injury but managed to claim his best match figures of 5/72 in the 4th Test in Kingston, Jamaica.