Many relatives were named after the judge, including grandnephews Edmund Pendleton (1776–1820, Edmund Jr.'s son), Edmund Pendleton (1790–1823, son of Nathaniel Pendleton's son Philip), Edmund Pendleton (1786–1838, son of Henry Pendleton), and General Edmund Pendleton Gaines (1777–1849). His nephew Nathaniel Pendleton, Jr. distinguished himself in the American Revolution as an aide to General Nathaniel Greene, and later became a lawyer and United States District Judge for Georgia. In turn his son Edmund Henry Pendleton (1788–1862) also became a judge, as well as a U.S. congressman for New York. Another descendant, Edmund Monroe Pendleton (1815–1884), distinguished himself in developing fertilizer products, and became a professor of Agriculture and Horticulture at the University of Georgia. Philip Clayton Pendleton (1779–1863) also served as a United States District Judge, and Philip Pendleton Barbour (1783–1841) served as an Associate Justice of the United States Supreme Court after serving as Speaker of the United States House of Representatives (his brother James Barbour was Virginia's 18th Governor as well as later a United States Senator and Secretary of War). Edmund Henry Pendleton (1843–1910) served in the 4th New York artillery as a Union staff officer in the Civil War; Rev. and Brig. General William Nelson Pendleton (1809–1883) commanded the Rockbridge Artillery and Confederate artillery units in that war, and his son Sandie Pendleton (1840–1864) became a distinguished staff officer before dying in the Valley Campaigns of 1864.