Meche lost his first four decisions of the season. On June 13, 2000, he tossed a one-hitter against the Kansas City Royals. After coming back to go 4–0 with a 2.64 ERA through his July 4 start against Anaheim, Meche was lifted in the sixth inning having thrown 113 pitches. His season was cut short due to what was thought at the time to be a dead arm. He went 1–2 with a 3.15 ERA in five rehab starts, but did not pitch at the major league level again for the rest of the season.