Arguello successfully defended his lightweight title four times. After defeating James 'Bubba' Busceme by sixth round stoppage, Argüello decided to move up in weight class again, and on November 12, 1982, he tried to become the first world champion in 4 different categories, meeting the heavier and future Hall-of-Famer Aaron Pryor, in what was billed as "The Battle of the Champions" in Miami, Florida. Argüello was stopped in the 14th round. The fight sparked controversy however, because Pryor's trainer, Panama Lewis, introduced a second water bottle which he described as "the bottle I mixed" after round 13, leading to speculation that the bottle was tainted. The Florida State Boxing Commission failed to administer a post-fight urinalysis, adding to speculation that the bottle contained an unsanctioned substance. Lewis claimed at various times that the bottle was filled with peppermint schnapps or Perrier to help Pryor deal with an upset stomach. It was later revealed in an interview with former Lewis-trained boxer Luis Resto that Lewis would break apart antihistamine pills used to treat asthma and pour the medicine into the water, giving Lewis's fighter greater lung capacity in the later rounds of a fight.