At her first clay-court event, Abierto Mexicano Telcel in Acapulco, Vinci defeated sixth seed Lucie Šafářová in the first round, and then fell to Ágnes Szávay of Hungary. Vinci then lost in the second rounds of both the Monterrey Open (defeated by Iveta Benešová) and the Paribas Open in Indian Wells (defeated by Sybille Bammer), and fell in the qualifications for Miami Sony Ericsson Open to Anastasia Rodionova. Vinci then fell to eventual champion and former world No. 1, Jelena Janković, in the quarterfinals of the Andalucía Tennis Experience in Marbella. At the Barcelona Ladies Open, Vinci earned her second career title, defeating Pauline Parmentier in the first round, Flavia Pennetta in the second, Anastasiya Yakimova in the quarterfinals, Francesca Schiavone in the semifinals, and defending champion Maria Kirilenko in the final.