Josland was the first to investigate the use of a vaccine to control Salmonellosis in sheep. He discovered an injection of formalised alum-precipitated Salmonella Typhi Murium vaccine resulted in low and inconsistent antibody response. Even though a greater number of vaccinated animals survived following challenge, compared to unvaccinated animals, he concluded that prophylactic vaccination was of little use. He was able to recommend control measures but stressed that early diagnosis by the clinician, confirmed by laboratory analysis, was important if hygiene and isolation measures were to be successful.