"Goldsborough" departed Norfolk 30 October 1942 to escort the seaplane tender to Panama and the seaplane tender to aviation patrol bases at San Juan, Puerto Rico; Trinidad; and Bermuda, Florida. She returned to Norfolk on 30 November 1942 to spend the following year as escort for "Albemarle" while carrying men, aeronautical cargo, and aircraft of Fleet Air Wings of the U.S. Atlantic Fleet to Guantanamo Bay; Trinidad; Bermuda; San Juan; and Recife, Brazil. She returned to Norfolk on the last of these missions 5 September 1943. After patrolling with the antisubmarine warfare task group from 5 October-15 November 1943, "Goldsborough" was redesignated DD-188 on 1 December 1943.