Paxton taught from 1906 to 1913 at the Museum of Fine Arts School and painted briefly at Fenway Studios in Boston. He worked at the Harcourt Street Studios in Boston and when it burned in 1904 he lost close to 100 paintings. He then went to the Fenway Studios for a brief period but then moved on to the Riverway Studios, also in Boston. He is primarily known for his portraits and painted both Grover Cleveland and Calvin Coolidge. Maryhill Museum of Art says of his artistry, "Paxton was well known for the attention he gave to the effects of light and detail in flesh and fabric. His works often present idealized views of women, such as this portrait ("The Red Fan") of his wife Elizabeth", like Henry James's portrayal of women in his novels "The Portrait of a Lady" (1881) or "The American" (1877). His models, often daughters and wives of his patrons, were depicted as refined, cultured women of "conspicuous leisure", and equated with the "precious aesthetic objects surround them", like the women of Thorstein Veblen's "Theory of the Leisure Class" (1899) who reflect the wealth of their husbands or fathers. He crafted elaborate compositions with models in his studio, using props that appear in several paintings.