The molecular mechanism that underpins Ping-Pong likely involves several piRNA pathway associated factors. "Qin" was reported to coordinate the loading of Ago3 with piRNA, in addition to interacting with both Aub and Ago3. However, the Tudor protein "krimper" () was also shown to interact with both Aub and Ago3 through its Tudor domains while also binding itself through its N-terminal Krimper domain. Specifically, Krimper interacts with Ago3 in its piRNA-unloaded state, while its interaction with Aub is dependent on the symmetrical dimethylation of arginine residues in the N-terminal region of Aub. In Silkmoth germ cells, it was proposed that Vasa protein coordinates the Ping-Pong mechanism of Silkmoth Aub (Siwi) and Ago3.