On November 20, Green sustained a tear to his hamstring in the first quarter of a Week 11 16–12 loss to the Buffalo Bills. He was inactive for the next five games before being placed on injured reserve prior to the regular-season finale. He finished the season with 66 receptions, 964 receiving yards, and four touchdown receptions in ten games and ten starts. The 2016 season was Green's first in the NFL without reaching 1,000 yards receiving, coming up 36 yards shy. Despite the injury, Green was named to his sixth straight Pro Bowl on December 20. He was ranked 17th by his peers on the NFL Top 100 Players of 2017.