At this point, the route heads onto the mainland and passes between two marinas before it comes to an eastbound RIRO intersection with Seward Marina Road (MD 835) and a westbound RIRO intersection with Kent Narrows Road (MD 835G), both providing access to MD 18, in the community of Kent Narrows. The road passes through marshland before heading near homes and businesses and reaching an eastbound RIRO intersection with MD 18F, which connects to MD 18, and a westbound RIRO intersection with Jackson Creek Road (MD 18U) in Grasonville. US 50/US 301 continue east past development and come to an interchange with Chester River Beach Road (MD 18V); this interchange does not have a westbound exit. From here, the freeway runs through wooded areas prior to reaching an eastbound RIRO intersection with Station Lane (MD 18I) and a westbound RIRO intersection with VFW Avenue (MD 18W). The road curves northeast and heads near residential and commercial areas, with an eastbound RIRO intersection at Evans Avenue (MD 18Z) before an eastbound RIRO intersection at Hess Road (MD 18X) and a westbound RIRO intersection at Hissey Road (MD 835I). The route reaches an interchange with Nesbit Road (MD 835K), which serves the University of Maryland Shore Emergency Center at Queenstown and the University of Maryland Shore Medical Pavilion at Queenstown to the south of the road, before it runs through woodland. US 50 and US 301 split at a half-trumpet interchange near Queenstown, with US 301 continuing northeast along the carriageways on the Blue Star Memorial Highway towards Delaware.