In 2001, Dantzler rushed for 1,075 yards and 13 touchdowns. He became the first player in NCAA football history to pass for more than 2,000 yards and rush for more than 1,000 in a single season, and only the third player in NCAA history to pass for more than 5,000 yards and rush for more than 2,500 yards in his career. Against The Citadel, he set school records for completion percentage and passing efficiency, by completing 16 of 17 passes. Against ninth-ranked Georgia Tech, he contributed to a 47-44 upset, rushing for 164 yards while passing for 254 yards and scoring the game-winning touchdown in overtime with an 11-yard run. Against North Carolina State University, he tallied 517 yards of total offense (fifth-best in ACC history), completing 23 of 27 passes for 333 yards.