Lois is the main character in the "Superman: Lois Lane" #1 one-shot. In this story, Lois' sister, Lucy, asks for her help in finding her roommate Amanda Suresh, who had been kidnapped by a mysterious group called "the Cartel." According to Lucy, Amanda had been taking a drug that transformed her into a monster. As Lois investigates the Cartel, she gets captured and taken to the Cartel's headquarters. There, Lois finds out the Cartel had been capturing people who had been mutated by the drug. Lois escapes and rescues Amanda when the captured monsters cause a riot. As she returns home, Lois finds out Lucy had been taking the drug. As Lucy apologizes for putting all three in danger, Lois chooses to publish her story about the Cartel.