Homme met Australian singer and musician Brody Dalle at Lollapalooza in 1996, when he was 23 and she was 17; he was there to perform with Screaming Trees, while she was there to see her then-boyfriend Tim Armstrong's band Rancid. They reconnected seven years later in 2003, during her separation from Armstrong, and began dating. Homme claimed to have received multiple death threats from Armstrong and Rancid fans. The two were married on December 3, 2005. They have a daughter named Camille Harley Joan Homme (born January 17, 2006) and two sons named Orrin Ryder Homme (born August 12, 2011) and Wolf Dillon Reece Homme (born February 13, 2016). Dalle filed for legal separation in November 2019 and divorce a month later, citing Homme's alcoholism and drug abuse; he subsequently entered rehab, but he and Dalle would accuse each other of domestic violence and have mutual restraining orders filed over the following months.