In January 2011 the 2nd Battalion, along with the 3rd Brigade Combat Team once again deployed to Afghanistan. The battalion conducted operations in Ghazni Province. On 27 February 2011 the battalion sustained its first casualties when one soldier was killed and four wounded by an IED. In its one-year deployment 2nd Battalion suffered 3 killed and 49 wounded while conducting over 1,900 combat patrols and 22 air assaults as they and their Afghan partners captured 111 caches and killed 250 insurgents. On 3 January 2012, following a change of authority ceremony with 1st Battalion, 2nd Infantry, the 2nd Battalion began departing Afghanistan. Since returning to Fort Knox the 2nd Battalion had a change of command and in training for its next deployment to Afghanistan.