Critical response to the manga has been positive. "Manga Life" enjoyed the setting, comparing it to the American Midwest in the 1800s. They called the lead's characterization "fantastic" based on the personality he displays when facing enemies as he refuses to murder anybody. Anime News Network compared the series with the chambara manga "Rurouni Kenshin" based on both's pacifist messages to the audience and how challenging is this message explored in a similar fashion to comic book hero Batman. He also praised the fight scenes' handling as well as villains' designs. The clash between him and his antagonist was also praised for his execution and artwork. However, "Mania Entertainment" said some events that happened to Vash might come across as repetitive because his pacifism keeps backfiring and no proper solution has yet been given. As Vash's philosophy was tested in the finale, "Fandom Post" praised the consequences of his actions. While Vash and Knives' was popular, to the point "Mania" referred to their final fight as "the stuff of legend." On the other hand, the book "" provided criticism to some parts of the narrative, finding it difficult to follow but still enjoyable. The artwork was also praised in the character designs with Wolfwood being called as one of the most stylish manga and anime characters.