Weed is at the intersection of Interstate 5 and U.S. Route 97. Interstate 5 is the primary north–south transportation corridor for the west coast of the United States running from the Mexico–US border to the Canada–US border. U.S. Route 97 is a major north-south U.S. highway continuing from Weed in a northeasterly direction toward Klamath Falls, Oregon, thence through Oregon and Washington to the Canada–US border. California State Route 265 also runs through the City of Weed, locally known as North Weed Boulevard. Only two blocks long, it is the second-shortest state highway in California.