The episode was written by Tom Devanney and directed by James Purdum. It received mixed reviews for its storyline, and many cultural references. According to Nielsen ratings, it was viewed in 9.23 million homes in its original airing. The episode featured guest performances by Jon Benjamin, Max Burkholder, Phyllis Diller, Phil LaMarr, Joe Lomonaco, Tamera Mowry, Anne-Michelle Seiler, Tara Strong, Nicole Sullivan, Gore Vidal, Gedde Watanabe, and Wally Wingert along with several recurring guest voice actors for the series. "Mother Tucker" was released on DVD along with twelve other episodes from the season on September 18, 2007.