Karen Maguire (also Jackson) is the daughter of Sheila Jackson (Maggie O'Neill) and her second husband, Eddie Jackson (Steve Pemberton). Nigel and Delia are her half-brother and sister. She becomes estranged from both parents throughout the series. She is Lip Gallagher's (Jody Latham) love interest in series 1, soon his father Frank Gallagher moves in with her & her mother, and at first she’s appalled by him and the idea of living with him, to the point she seduces him into sleeping with her, in the hopes Sheila catches him and kicks him out under the assumption that Frank sexually assaulted her underage daughter, however after the fallout between Frank & Lip, and seeing Sheila show genuine concern for Frank can’t bring herself to tell her mother the truth, She then leaves to stay with her grandmother. In series 2 she returns to Chatsworth, drops out of school to work at the Jockey where she lies about her sexuality to guarantee herself a position and moves out entirely from Sheila's house to live at The Jockey. She is the only other character aside from Frank to appear in every series. Karen appeared in 129 episodes in total.