As the 1950 Detroit Tigers season started, Houtteman was on a high note, pitching all of spring training without allowing a walk. He won his tenth game of the season on June 28, 1950, and became the first pitcher to hit the 10-win mark alongside Bob Lemon. After the game, he told an Associated Press reporter that he was just about convinced that Lady Luck had decided to give him a break after kicking him around for the past two or three years. Houtteman said, "I've been having a pretty good year and it sure feels good after some of the things that have happened to me". A week into July, Houtteman notched his eleventh victory, and only lost five games, in a 6–1 win against the St. Louis Browns. Just a few days later, Houtteman was named to the All-Star roster alongside fellow Tigers including Ted Gray, George Kell and Hoot Evers. In the 1950 All-Star game, Houtteman pitched three innings and batted once. He allowed one earned run, three hits, and one walk, his one earned run coming in the ninth inning on a Ralph Kiner home run that made the game go to extra innings.