After entering the state of New Mexico, U.S. 70 heads southeast. Five miles (8 km) after crossing the state line, it serves as the southern terminus for New Mexico State Road 92. U.S. 70 does not have another highway junction for 21 mi (34 km), where it meets State Roads 464 and 90 three miles (5 km) north of Lordsburg. At Lordsburg, U.S. 70 joins with Interstate 10 eastbound, splitting off in Las Cruces, and becoming Picacho Avenue in Las Cruces. When Picacho Avenue meets Main Street, US 70 follows Main Street northbound. U.S. 70 then crosses Interstate 25, and has been upgraded at this point to a controlled access highway until entering the foothills of the Organ Mountains.