On October 6, 2017, Stamkos played in his first game since injuring his knee the prior season. Stamkos recorded an assist in his return, which resulted in a 5–3 Lightning win over the visiting Florida Panthers. On October 12, Stamkos scored his 112th power play goal, which tied him with Vincent Lecavalier for the most power play goals in franchise history. On October 21, Stamkos scored his 113 power play goal, against Antti Niemi of the Pittsburgh Penguins in a 7–1 Lightning win at the Amalie Arena. The goal moved Stamkos past Lecavalier for most power play goals in franchise history. During that game, Stamkos also recorded his 600th career NHL point. On October 26, Stamkos recorded a point in his 11th consecutive game to start the season. In so doing, Stamkos tied Martin St. Louis for the longest season-opening point streak in Lightning history. Stamkos' streak ended the following game. On November 2, Stamkos skated in his 600th career NHL game. The following day, Stamkos was fined $5,000 for unsportsmanlike conduct after spraying his water bottle at a referee during the previous night's game. On November 17, Stamkos scored four points in a 6–1 Lightning win over the visiting Dallas Stars. This was Stamkos' fourth four-point game, which tied Stamkos with Martin St. Louis and Vincent Lecavalier for the most four-point games in Lightning history.