Vlady spent most of his career in Mexico with trips back to Europe, gaining fame in the 1960s. In the 1970s, he was invited to paint murals at the Miguel Lerdo de Tejada Library, a 17th-century building in the historic center of Mexico City. The result was Las revoluciones y los elementos" dedicated to the various modern revolutions in the world including the sexual revolution of the mid 20th century. The work was somewhat controversial but it led to other mural work in Nicaragua and Culiacán. Vlady received a number of awards for his life's work including honorary membership with the Russian Academy of Arts. A number of years before his death in 2005, the artist donated 4,600 artworks from his own collection, about a thousand of which are found at the Centro Vlady at the Universidad Autónoma de la Ciudad de México, which is dedicated to research and promotion of the artist's work.