Toxic substances and poisons (like atropine) can significantly reduce the range of aperture. Pharmaceutical products such as eye drops may also cause similar side-effects. Tropicamide and phenylephrine are used in medicine as mydriatics to dilate pupils for retinal and lens examination. These medications take effect in about 30–45 minutes after instillation and last for about 8 hours. Atropine is also used in such a way but its effects can last up to 2 weeks, along with the mydriatic effect; it produces cycloplegia (a condition in which the crystalline lens of the eye cannot accommodate to focus near objects). This effect goes away after 8 hours. Other medications offer the contrary effect. Pilocarpine is a miotic (induces miosis); it can make a pupil as small as 1 mm in diameter depending on the person and their ocular characteristics. Such drops are used in certain glaucoma patients to prevent acute glaucoma attacks.