NY 352 east begins to bend northeast through Elmira, leaving the West Elmira section, remaining a two-lane residential street. The route returns to the Chemung River once again, passing north of Clinton Island. The route winds eastward, becoming a commercial street through the city, intersecting with South Main Street and Railroad Avenue. At Railroad Avenue, the Southern Tier Line crosses over the alignment from a bridge over the Chemung. Now known as East Water Street, NY 352 soon intersects with NY 14 (Clemens Center Parkway). NY 352 continues eastward for several blocks alongside the Chemung River, passing several baseball fields and industrial buildings, soon entering a diamond interchange (exit 56) with the Southern Tier Expressway (now just NY 17). This interchange serves as the eastern terminus of NY 352, where the right-of-way continues east of CR 1 (Jerusalem Hill Road).