The first large business in Bromide was a limestone quarry, established by Robert Galbreath Jr., a Tulsa businessman. Stone became economically important about 1911, when the Missouri, Oklahoma and Gulf (MO&G) Railway (later bought by the Kansas, Oklahoma & Gulf (KO&G)) built a spur into Bromide. A rock-crushing plant was built just outside the city. Galbreath built a three-story hotel from rock quarried there. The KO&G promoted Bromide as "the best health resort in the southwestern states". It also ran weekly excursions to the city. Three more hotels, a bathhouse, and a swimming pool were added to support the tourist trade. By 1920, the population had reached 520. The Great Depression dried up the tourist trade. The population of Bromide fell to 352 in 1930, 258 in 1950, and to 180 in 1980. KO&G abandoned its line in 1950.