The portion of SR 25 running from the I-475/US 23 diamond interchange in Perrysburg to the I-75 interchange near downtown Toledo is included within the National Highway System. A 2009 traffic report from the Ohio Department of Transportationt showed that the lowest traffic levels were the 5,287 vehicles used the highway daily on the section near its southern terminus, between I–75 and SR 281 in Wood County, while peak traffic volumes were 61,648 vehicles along a section of SR 25 between SR 120 and I–280.