SR 25 enters downtown Toledo and the highway becomes one-way streets, with northbound on Erie Street and southbound on Michigan Street. The two streets are two blocks apart and the Lucas County Court House is between them. At the northeast corner of the Court House northbound SR 25 turns northwest on Cherry Street and joins SR 120. After a couple blocks, Cherry Street meets southbound SR 25 at Spielbusch Avenue. After a turn to the northeast, the route becomes a four-lane divided highway known as Greenbelt Parkway. Northeast of SR 120 the highway passes through woodland and industrial properties. The northern terminus of SR 25 is at an interchange with I–280, with the roadway continuing northeast. The Parkway ends northeast of the interchange at Galena Street in a wooded area near the Toledo Correctional Institute.