During the existence of this public high school, it has been known successively as the Manor Township High School, Manor-Millersville High School, and Penn Manor High School. Manor Township High School held its first graduation in 1922 at the Model School on George Street across from Old Main in Millersville, Pennsylvania. In 1932 Millersville became a borough, and the high school was operated jointly by the school directors of Manor Township and Millersville Borough. The school was renamed Manor-Millersville High School. Pupils from Conestoga, Martic and Pequea Townships as well as Washington Boro attended the school on a tuition basis. On July 13, 1953, an agreement was signed by six school boards – Conestoga Township, Manor Township, Martic Township, Millersville Borough, Pequea Township, and Washington Boro – to construct and operate a new junior-senior high school, to be named Penn Manor High School.