On 12 August 1818, they headed North-North East to Rio Carinhanha, as far as the Serra Geral then returned by Codó to Carinhanha arriving at Rio de Contas on 17 October 1818, then riding east to cross the Rio Paraguaçu arriving at Salvador on 10 November 1818, and leaving on 18 February 1819 via Coit and Jacobina. The party then travelled to Piaui, Oeiras where they arrived on 3 May. They departed on 11 May, arriving on 15 May at São Gonçalo do Amarante, where Martius became seriously ill. Spix had at this time contracted the schistosomiasis from which he eventually died.