Creamer changed swing instructors before the start of the 2016 season. Having worked with David Whelan for 15 years, she began receiving instruction from Gary Gilchrist after Whelan left his position at IMG Academy. At the first LPGA tournament of 2016, Creamer posted a top-five result at the Pure Silk-Bahamas LPGA Classic. She tied for fourth place at the JTBC Founders Cup, before going into an extended slump in performance in which she missed the cut seven times. Her 2016 LPGA Tour earnings fell under $300,000, outside the top 60.