From its origins in the 1400s until its dissolution in 1833, the Casa da Índia's principal objectives changed with time, as did its relationships with the Crown of Portugal and the imperial administration. Following 1642, it lost all of its trade monopolies on gold, silver, ivory, spices, and other precious commodities, transforming the organization's purview to solely a trade regulator and customs agency. Following the destruction of its Ribeira Palace headquarters and facilities in the Great Lisbon Earthquake of 1755, the Casa da Índia grew increasingly obsolete in relation to Portugal's transforming trade and colonial policies, leading to most of its functions being slowly absorbed into ministries and agencies of the Portuguese government until its final dissolution in 1833.