Longoria was named the cover athlete for "Major League Baseball 2K10", succeeding Tim Lincecum. Longoria also appears in a commercial for the game that advertises the $1 million prize given to the first person to pitch a perfect game in MLB 2K10. In the commercial, Longoria breaks up a perfect game with a home run. On August 8, 2010, Longoria broke up a no-hitter in the ninth inning with two outs. Longoria spoiled Brandon Morrow's attempt with a putt-shot to the Blue Jays' second baseman, who was unable to make a play on it. Brandon Morrow was left with a 17-strikeout one-hitter (which would have tied Nolan Ryan for most strikeouts in a no-hitter).