George Herdle organized an ambitious exhibition schedule with multiple exhibitions changing monthly. Significant early exhibitions included the 1914 exhibition at which the original Kodachrome two-color process was introduced, and in 1919 a controversial solo exhibition by George Bellows. Annual exhibitions of the Rochester Art Club were also held at the Gallery. In the early years, these changing exhibitions were supplemented by summer loan exhibitions from the private collections of George Eastman, the Sibleys, the Watsons, and other prominent Rochester families. With Herdle's untimely death in 1922, his daughter and University of Rochester graduate, Gertrude L. Herdle began what would become a 40-year career as the museum's director. Another daughter, Isabel C. Herdle, served in various curatorial roles beginning in 1932 after schooling at the University of Rochester, with graduate work at Radcliffe College and Paul Sachs' museum studies course at the Fogg, the Courtauld Institute of Art, and the Royal Institute of Technology in Stockholm. Before joining her sister at the Memorial Art Gallery, Isabel Herdle worked for one year at the de Young museum.