Early worship took place at the parish church of Manchester, however a small chantry chapel existed in 1368 on the only bridge linking the two settlements. In the 16th century, it was converted into a dungeon, and was later demolished in 1779. In 1634–35, Humphrey Booth, a wealthy local merchant, opened a chapel of ease, which a year later was consecrated as the Chapel of Sacred Trinity (the parish of Sacred Trinity was created in 1650). John Wesley preached in the building, before his break with the Anglican Church. However, upon his return in 1747, he preached in the open, at Salford Cross. The chapel was rebuilt in about 1752–53, although the tower probably belonged to the original building. It was restored in 1871–74 by the architect J. P. Holden and a chapel was added to the south-east in 1934. It is now a Grade II* listed building.