The elevation of the land area of Cairo (ranges from about 812' at the west end to 842' at the east end of the village above sea level) is benchmarked at above sea level, generally flat and moderately wooded. The nearest stream with year-round flow is Rattlesnake Creek, which flows from south of the village and passes just to the west of the village. Water flow in the village is generally from the south and east to the north and west.