The Hillsboro and Cincinnati Railroad was chartered in 1846 to run a line between Hillsboro and O'Bannon Creek in Loveland on the Little Miami Railroad's route. By 1850, the H&C had completed the to Hillsboro, Ohio. The H&C would lease its line in perpetuity to the Marietta and Cincinnati Railroad and ultimately became the mainline of the Baltimore and Ohio Railroad. Loveland's location at the junction of the Little Miami Railroad (now converted into the Loveland Bike Trail) and the Marietta and Cincinnati Railroad fueled the city's growth, bringing "40 passenger trains per day, and 12 scheduled freight trains between Loveland and Cincinnati."