Astra Giurgiu played its first European match ever in first qualification round of UEFA Europa League against Domžale, winning 1–0 in the first leg. In the second leg in Bucharest, Astra won 2–0 and qualified. In the second qualification round, Astra draw 1–1 with Omonia in the first leg in Bucharest and beat 2–1 in the second leg in Nicosia to advance. Seeded team after eliminating Omonia, Astra was drawn in third qualification round with Trenčín and qualified after winning 3–1 the first leg in Dubnica nad Váhom and drawing 2–2 in the second leg in Bucharest. In play-off, Astra faced the very first European defeat in a 0–2 against Maccabi Haifa in the first leg in Haifa, thus being eliminated after drawing 1–1 in the second leg in Bucharest.