In 2007, Banks played the female lead in the comedy film "Meet Bill", alongside Aaron Eckhart and Jessica Alba. That same year, she had a small role as Santa's little helper, Charlyne, in the Christmas comedy film "Fred Claus", co-starring Vince Vaughn and Paul Giamatti. In 2008, she played the ex-wife and mother of the daughter of Ryan Reynolds lead in the comedy film "Definitely, Maybe", alongside Isla Fisher and Ryan Reynolds, starred with Seth Rogen as the eponymous female lead in the Kevin Smith comedy "Zack and Miri Make a Porno", and played United States First Lady Laura Bush in "W.", Oliver Stone's biopic of George W. Bush.