In the following loss to the Oakland Raiders, Slaton rushed 18 times for 66 yards and caught five passes for 36 yards. It marked the first time in four games that he did not rush for over 100 yards (although he totaled 102 yards of offense), however he broke the franchise single-season record for rushing yards with 1,190 yards. In the final week of the season, Slaton's Texans were pitted against the Chicago Bears who had a talented rookie running back of their own in Matt Forte. Slaton rushed for 92 yards and a score to seal Houston's win. He ended his rookie season with 1,282 rushing yards, the most among rookie running backs and sixth in the NFL, behind only Adrian Peterson of the Minnesota Vikings, Michael Turner of the Atlanta Falcons, DeAngelo Williams of the Carolina Panthers, Clinton Portis of the Washington Redskins, and Thomas Jones of the New York Jets.