Through much of this portion, the road is divided, with a tree-lined median strip. Businesses, both local and national, line both sides of the road and traffic is heavy. It crosses some other major strips such as Niagara Falls Boulevard (U.S. Route 62 or US 62), a major contributor to traffic on Sheridan due to the proximity of the Boulevard Mall, and Millersport Highway (NY 263), which feeds the Amherst campus of the University at Buffalo. In Amherst it meets the Youngmann Expressway (I-290) where NY 240 (Harlem Road), reaches its northern end. Past the Youngmann development abates, green returns to the roadside and the median ends, although the road remains four-lane and high-volume. There is another pocket of development around the Wegmans supermarket north of Williamsville, which has seen some rapid growth in the last few years.