In the early 1970s she played with The Phantoms of the Opry, a Bay Area bluegrass band that also included Pat Enright (later of the Nashville Bluegrass Band). When the Phantoms broke up she co-founded the Good Ol' Persons, an all-female bluegrass band with Kathy Kallick. In 1979 she founded the Grant Street String Band, also including Beth Weil, Tom Bekeny, Greg Townsend, and Steve Krouse, in which her own songwriting came to the forefront. In the late 1980s, she formed "Laurie Lewis and Grant Street". Since then, she has recorded solo and duo albums, usually accompanied by mandolin artist and singer, Tom Rozum. Nowadays, she often plays under different names with a fairly regular roster of musicians, calling themselves "Laurie Lewis and her Bluegrass Pals," "the Guest House Band;" in 2006, she renamed her group "Laurie Lewis and the Right Hands."