In her senior year at Harvard, Feaster-Strong led the nation in scoring, at 28.5 points per game, was 14th in rebounding (10.8 per game), and 16th in steals (3.3 per game). She was again honored as Ivy League Player of the Year and was also selected to the Kodak Division I Women's All-America Basketball Team. Despite a 22–4 record, the Ivy League champion Crimson were again a No. 16 seed for the NCAA Tournament. They played the No. 1 seeded Stanford Cardinal on Maples Pavilion, Stanford's home floor. When Harvard won the game, 71–67, backed by 35 points and 13 rebounds from Feaster-Strong, they became (until UMBC's defeat of UVA in 2018) the only No. 16 seed in the history of the NCAA men's or women's Division I basketball tournament to defeat a No. 1 seed in the first round. No other team seeded lower than No. 13 has ever won a game in the women's NCAA Tournament.