Two years later, at the 2007 EuroBasket, Spanoulis was again part of Greece's team. Greece played the tournament shorthanded, as it was without key players, Antonis Fotsis and Sofoklis Schortsanitis, and was not able to medal in the tournament. Greece finished in 4th place in the tournament, losing in the semifinals game against the Spanish national basketball team, and its numerous star players, like Marc Gasol, Juan Carlos Navarro, José Calderón, Sergio Rodríguez, Jorge Garbajosa, Rudy Fernández, and Pau Gasol. Spanoulis was the game's leading scorer, with 24 points, and he also dished out 5 assists, but Spain got the win, by a score of 82–77, over the depleted Greek squad. Spanoulis led the Greek team in scoring during the tournament, with a scoring average of 11.7 points per game.