He bought his first cargo vessel in 1938 and by the 1960s, owned a fleet of ships. In 1955, Latsis purchased a cargo vessel, the Marianna. Three years later, he purchased his first oil tanker, the Spyros, which was used for the transportation of liquid molasses from Egypt to Greece and the UK. In the following years, his fleet expanded significantly, with the acquisition of passenger vessels, cargo ships and oil tankers. In the 1990s, Latsis’ fleet was one of the largest under Greek ownership.