Upon leaving Fishing Creek Township, about after picking up Huntington Creek, Fishing Creek flows southwest past Knob Mountain and into Orange Township. It passes near the northern edge of Knob Mountain downstream, then by Orangeville, and makes a 90° turn to the northwest. Shortly after this turn it picks up Green Creek above its mouth and turns west. After some distance, it turns south again, passing Bowman Bridge and a gauging station. From this point, the creek flows along the border between Orange and Mount Pleasant Townships for almost . While on the border between these two townships, it flows past Kocher Park. The creek stays considerably nearer to the western edge of the river valley than the eastern edge at this point. Near Lightstreet, it turns west into Mount Pleasant Township, passing several lakes and the Turkey Hill Oxbow. Upon entering Mount Pleasant Township, the creek stops paralleling Pennsylvania Route 487 and flows in the vicinity of Interstate 80 for .