On the November 25 episode of "Raw", Mysterio won a fatal five-way elimination match to become the number one contender for the United States Championship. Later that night, he defeated AJ Styles to capture the United States Championship for the second time. During a house show at Madison Square Garden on December 26, Mysterio lost the title to Andrade, ending his reign at 31 days. He then attempted to win the title back on the January 6, 2020 and January 20 episodes of "Raw", but Andrade successfully retained the title. On the April 20 episode of "Raw," Mysterio defeated Murphy to qualify for the Money in the Bank ladder match. At Money in the Bank, Mysterio failed to win the match.