The Big Lost River is about long has two main tributary forks, the North Fork Big Lost River and the East Fork Big Lost River. The river originates in the Pioneer Mountains in Salmon-Challis National Forest, flows northeast then turns southeast, with the Lost River Range to the east separating the Big Lost River Valley from the Little Lost River Valley. A dam impounds the river and creates Mackay Reservoir. Near Arco the river enters the Snake River Plain, curves east and then northeast and enters the depression where the water flows into the ground, called Big Lost River Sinks. Near the sinks there is a dry distributary called the "Dry Channel Big Lost River".