The line is single here with a passing loop approximately east of Hairmyres Station, which extends for approximately to Kirktonholme Road East Kilbride. It is crossed mid-loop by the A726 Queensway overbridge. Although the line was always single between and East Kilbride, sidings existed to serve the former Radio Times factory in the College Milton Industrial Estate adjacent to the station. These were closed and lifted in the late 1960s. The Hairmyres Hospital and Department for International Development's office are located nearby.