In their experiments with projection neurons in the hippocampus and cerebellum, both groups noticed that a train of action potentials in these cells resulted in a temporary reduction in inhibitory currents caused by GABA-ergic interneurons. Since this reduction of inhibitory currents could be invoked simply by depolarization of the target cell, this phenomenon was termed depolarization-induced suppression of inhibition. While initially discovered in CA1 neurons of the hippocampus and Purkinje cells in the cerebellum, depolarization-induced suppression of inhibition is a pretty ubiquitous phenomenon and has been demonstrated in other areas of the brain such as the basal ganglia, the cortex, the amygdala, and the hypothalamus (Katona "et al." 2001, Jo "et al." 2005, Bodor "et al." 2005, Matyas "et al." 2006)