Reynolds suffers from ankylosing spondylitis, which he announced at Leeds First Direct Arena in 2015 during the band's Smoke + Mirrors tour. In 2016 he partnered with Novartis's ThisASLife to raise awareness about the severe inflammatory disease. During the same year, Reynolds said in an interview that he had been heavily depressed for the past two years and often sees a therapist. He has also suffered from ulcerative colitis since the age of 21. Many songs on "Night Visions" were inspired by his depression. He aims to destigmatize and change how society sees depression and the act of seeking professional help. In April 2018, he began to talk about his physical and mental health struggles on his social media accounts and continues to offer encouraging messages of support to his fans and others struggling as well.