Mysterio was the second entrant in the 2006 Royal Rumble match. He won the match and earned a world title shot, last eliminating Randy Orton. He lasted 62 minutes, a Royal Rumble record. Orton urged him to put the title shot at stake in a match at No Way Out. In the weeks preceding No Way Out, Orton made disparaging remarks about Eddie Guerrero. Many fans felt the comments were unwarranted and distasteful in the wake of Guerrero's death in November 2005. Orton won at No Way Out, earning Mysterio's title shot for the World Heavyweight Championship at WrestleMania 22. General Manager Theodore Long re-added Mysterio to the WrestleMania title match however, making it a Triple Threat match between Orton, Mysterio, and then-champion, Kurt Angle. At WrestleMania, Mysterio pinned Orton to become the new World Heavyweight Champion. On the following episode of "SmackDown!", Mysterio – who was billed as being an "underdog champion", made his first successful World Heavyweight title defense against Orton. Mysterio went on to retain his title again during a WrestleMania rematch on "SmackDown!" against Angle three weeks later.