This game features a side story in "The House of the Dead" plotline, taking place shortly after "The House of the Dead 4", with Kate Green teaming up with Agent "G" to destroy the zombie infestation at its source, leading them to confront the Magician, a boss character who returns after having been obliterated in the first two installments. This game only features two bosses, Justice (Type 0053) and The Magician (Type 0); "G" and Kate encounter the latter boss in a room of a building that "G" bellieves to be the source of the zombie infestation. In order to defeat the Magician, players must reduce its life bar to zero, then throw a grenade within 10 seconds to destroy a controller it picks up.