When the Southern Plains Indians opened the Red River War in June 1874, the Grant administration discarded its Quaker peace policy and authorized the military to take control of the reservations and subdue all hostile Indians. General Philip H. Sheridan, commander of the Division of the Missouri, ordered five military expeditions to converge on their hideouts along the upper Red River country. In the ensuing campaign, the 4th Cavalry was the most successful. On 26–27 September, it staved off a Comanche attack at the head of Tule Canyon, and, on the morning of 28 September, descended by a narrow trail to the bottom of Palo Duro Canyon. There it completely destroyed five Comanche, Kiowa, and Cheyenne villages, including large quantities of provisions, and captured 1,424 horses and mules, of which 1,048 were slaughtered at the head of Tule Canyon. Afterward, Mackenzie, with detachments of the regiment, made two other expeditions onto the High Plains. On 3 November, near the site of Tahoka, in their last fight with the Comanches, the cavalrymen killed two and captured nineteen Indians. In the spring of 1875, Mackenzie and elements of the 4th Cavalry from various posts in Texas were sent to Fort Sill to take control of the Southern Plains Indians.