He went at an early age to Rome, probably to work as an assistant to Antonio da Sangallo the Elder, where he had opportunities to study classic sculpture and architecture. In 1509 he went to Orvieto where he practiced for the next two decades. Among his earliest works are the first design of the "duomo" of Montefiascone, initiated in 1519, an octagonal building surmounted with a dome, and the church of Santa Maria delle Grazie, he designed and built the funerary chapel for the Petrucci family in the Gothic church of San Domenico in Orvieto. Several palazzi at both places are attributed to him.