Longoria hit his first career home run on April 14, against the New York Yankees at Tropicana Field. He had his first career two-homer game on May 24, and drove in six runs as the Rays defeated the Baltimore Orioles 11–4. Both of the homers came off the Orioles' Steve Trachsel, also a Long Beach State alumnus. On July 19, 2008, Longoria hit his first career grand slam off Toronto's Roy Halladay in the fifth inning as part of a 6–4 winning effort.