Sam runs into Dean on the same case in "Sharp Teeth". Although Dean tries to divert Sam from the case so that they won't have to work together again, Sam reveals that he is willing to work with Dean again so long as it is on a strictly professional basis, telling him that they cannot work on a brotherly basis anymore because Dean has lost his trust. At the end of "The Purge", Sam responds to Dean's attempts to justify his decisions by saying that Dean's choices are not as selfless as Dean paints them and that he would not have done what Dean did given the same situation, which stuns Dean into silence.