Oronamin C was introduced in February 1965 and was initially sold in a 120 ml glass bottle sealed with a bottle cap. It contains isoleucine and many other essential amino acids as well as many vitamins such as vitamin B2, vitamin B6 and vitamin C. It is not only available in supermarkets and convenience stores in Japan, but also in Otsuka Pharmaceutical Co. vending machines as well. The bottle cap was briefly replaced with a screw bottle cap, but following a nationwide scare during the 1980s regarding a large number of poisoned sealed bottled beverages, this screw cap was replaced with a one-time "pull-cap," which cannot be re-sealed after opening. Child welfare activist Osamu Mizutani (水谷 修 "Mizutani Osamu", born May 8, 1956) wrote that the previous screw caps allowed individuals to put in paint thinner and then re-seal the bottles.