The striped skunk is a stoutly-built, short-limbed animal with a small, conical head and a long, heavily furred tail. Adult males are 10% larger than females, with both sexes measuring between 52 and 77 cm in total body length and usually weighing , though some may weigh . The feet are plantigrade with bare soles, and are not as broad or flat as those of hog-nosed skunks. The forefeet are armed with five long, curved claws adapted for digging, while those on the hind feet are shorter and straighter.