Meigs County lies in the Appalachian Plateau physiographic region of the Appalachian Mountains. The landscape is considered to be anywhere from gently rolling to rugged, typical of a dissected plateau. Elevations range from asl (above sea level) in the southwest to about asl in the far south central part of the county along the Ohio River. The majority of Meigs County is drained by two subwatersheds of the Ohio River, Shade River and Leading Creek. Another stream of note is Raccoon Creek, which flows through a small area of the northwestern corner of the county.