Mysterio participated in the main event of Survivor Series as part of Team SmackDown! along with Randy Orton, Bobby Lashley, Batista, and John "Bradshaw" Layfield who defeated Team Raw (Shawn Michaels, Kane, Big Show, Carlito, and Chris Masters). After Survivor Series, Mysterio started a feud with Big Show after Mysterio eliminated Big Show at Survivor Series, Mysterio would face Big Show in a match billed as "David vs. Goliath" in a "SmackDown!" special show, and ended as a "no contest" when Big Show's tag team partner Kane interfered in the match. Mysterio continued to feud with Raw's World Tag Team Champions, and found a tag team partner in World Heavyweight Champion Batista. They were booked to face Raw's Kane and Big Show in a tag match at Armageddon. Before Armageddon, Batista and Mysterio defeated MNM on the December 16 episode of "SmackDown!" to win the WWE Tag Team Championship in a match they both dedicated to Eddie Guerrero. Now the Tag Team Champions, Mysterio and Batista's match with Big Show and Kane was billed as "Champions vs. Champions." Mysterio and Batista lost the match when Kane pinned Mysterio after a chokeslam. On the December 30 episode of "SmackDown!", MNM invoked their rematch clause, defeating Batista and Mysterio after interference from Mark Henry to regain the WWE Tag Team Championship. The following week, Mysterio and Batista received their rematch for the titles in a steel cage match, which they lost after more interference by Henry. On the January 13, 2006, episode of "SmackDown!", Mysterio was involved in a 20-man battle royal for the vacant World Heavyweight Championship, but was eliminated by Henry.