Clinically speaking, the blocks tend to have more serious potential the closer they are to the "end" of the electrical path (the muscles of the heart regulated by the heartbeat), and less serious effects the closer they are to the "start" (at the SA node), because the potential disruption becomes greater as more of the "path" is "blocked" from its "end" point. Therefore, most of the important heart blocks are AV nodal blocks and infra-Hisian blocks. SA blocks are usually of lesser clinical significance, since in the event of SA block, the AV node contains a secondary pacemaker which would still maintain a heart rate of around 40 - 60 beats per minute, sufficient for consciousness and much of daily life in the majority of individuals.