In the 2008 season, Creamer won a career-high four LPGA events and made more than $1.8 million, the highest amount she has earned in a season. In February 2008, she earned her fifth LPGA title at the Fields Open in Hawaii, coming back from a late two-shot deficit with birdies on the final three holes. On April 27, Creamer came up short in a bid for her second win of the year, losing in a sudden-death playoff to Sörenstam at the Stanford International Pro-Am. The following week, Creamer bounced back at the SemGroup Championship by defeating Juli Inkster in a playoff. At the U.S. Women's Open, she entered the final round one shot off the lead and in good position to claim her first major championship victory. However, a five-over-par 78 on the last day dropped her into a tie for sixth.