In his university days, Perlas was one of the key organizers of a university-wide education reform movement that resulted in changes in university policies. During this time, he founded the first ecological society in the Philippines. After graduation, he co-organized a successful large scale global campaign, the first of its kind during his time, to halt 12 nuclear plants in the Philippines. Perlas subsequently become a technical adviser to the Presidential Commission on the Philippine Nuclear Power Plant, Office of the President of the Philippines, where he was instrumental in stopping the operation of the fully constructed and operational Bataan Nuclear Power Plant, a $2.2 billion project plagued with design, construction, location, and corruption problems.