Villa worked as an associate editor for New Directions Publishing in New York City from 1949–51, and then became director of poetry workshop at City College of New York from 1952 to 1960. He then left the literary scene and concentrated on teaching, first lecturing in The New School for Social Research from 1964 to 1973, as well as conducting poetry workshops in his apartment. Villa was also a cultural attaché to the Philippine Mission to the United Nations from 1952 to 1963, and an adviser on cultural affairs to the President of the Philippines beginning 1968.