Following "Secret Wars", Roberta is transported to the prime Marvel Universe with hallucinations of her past life. She was a supporting character in the All-New, All-Different Marvel "Spider-Man 2099" comic, where she was an employee at Parker Industries with Miguel O'Hara as her boss. After Roberta's powers resurface again, she becomes a recurring ally for Spider-Man 2099. During the "Civil War II" storyline, Roberta goes back to 2099 to find her family, despite Miguel's warnings. The Public Eye attempt to arrest her, until she is rescued by Ravage 2099. In the present, Miguel receives a call from Peter Parker, who tells him of a vision the Inhuman Ulysses had of the future: the death of Roberta Mendez. He goes back to 2099. Roberta learns from Ravage about the Anti-Powers Act, a law outlawing superpowers. Roberta and Ravage are taken to the downtown area by Hawkeye 2099, where they meet the remaining heroes. Spider-Man convinces Doctor Strange 2099 to help him out in exchange for his help in eliminating the A.P.A. Meanwhile, the CEO of Alchemax calls on Power Pack to defeat the heroes. Upon finding Roberta, Strange takes Spider-Man downtown, while Roberta leaves to find her husband upon learning his location. Roberta finds her husband Harry, who claims that she died and that they do not have kids, and gets captured by Power Pack. After Strange reveals that the CEO of Alchemax is J. Jonah Jameson, Spider-Man rallies the heroes to launch an assault on S.H.I.E.L.D. HQ and rescue Roberta. In the process, they discover that "Jameson" and "Power Pack" are actually Skrull impostors. Spider-Man and Roberta then go back to 2016 to restore the timeline. In the book's ending, Roberta and Miguel's son save Miguel from death and return to 2099 on New Year's Eve. Thanks to Miguel's sacrifice, Roberta's family history is restored.