Changes in expression of potassium channels and of potassium currents have been described in a model of temporal lobe epilepsy. In this model, there is downregulation of the A-type encoding Kv4.2 channel. This channel is involved in limiting backpropagation of action potentials and in reducing the transfer of excitatory postsynaptic potentials (EPSPs) from apical dendrites into the soma. In the same model, the aforementioned upregulation of t-type calcium channels also has been shown to result in increased burst behavior in neurons in the hippocampus.