In 1907, sisters Elizabeth, Jessie and Margaret Thomson, all former teachers of the Presbyterian Ladies' College, Melbourne, moved to Toowoomba, with the idea of establishing a girls' school conducted according to the standards of the Secondary Teachers' Association of Victoria. They leased the now heritage-listed house Spreydon, a property with over an acre of land on the corner of Warra and Rome Streets at Newtown in the west of Toowoomba, and on 4 February 1908, opened the privately owned Spreydon College, a Christian boarding and day school for girls. Commencing with a roll of 20 boarders and "quite a number of day girls", the school offered classes from Kindergarten to "Sydney Senior Standard". The Spreydon building housed the Principal and boarders' quarters, while a school room, Kindergarten and tennis court were established facing Rome Street.