PA 368 begins at an intersection with PA 268 (River Road) on the shores of the Allegheny River in the city of Parker. Just after the eastern terminus, the highway crosses over the Allegheny on the Parker Bridge. The highway crosses Perryville Road on an overpass, just before intersecting at a jughandle. After Perryville Road, PA 368 enters a small, rural region of Parker Township. At the intersection of Terwillger Road, the highway enters the community of Parkers Landing. Paralleling Perryville Road to the south, PA 368 passes a more suburban area of Parker Township. Just after leaving Parkers Landing, Perryville Road, which had been paralleling, merges back into the state route.