E. O. Lawrence was the inventor of the cyclotron, an accelerator of subatomic particles, and a 1939 Nobel Laureate in physics for that achievement. The Radiation Laboratory he developed at Berkeley during the 1930s ushered in the era of “big science,” in which experiments were no longer done by an individual researcher and a few assistants on the table-top of an academic lab but by large, multidisciplinary teams of scientists and engineers in entire buildings full of sophisticated equipment and huge scientific machines. During World War II, Lawrence and his accelerators contributed to the Manhattan Project, and he later played a leading role in establishing the U.S. system of national laboratories, two of which (Lawrence Berkeley and Lawrence Livermore) now bear his name.