The two routes serve as Oneonta's main street, following Chestnut and Main streets across the city's western and central areas. Along the way, NY 7 and NY 23 pass Hartwick College and serve Oneonta's central business district. NY 23 breaks from NY 7 just northeast of downtown to follow James F. Lettis Highway, a four-lane divided highway, south into the southern half of the city. As it heads south on the arterial, it connects to Interstate 88 (I-88) at an interchange on the northern bank of the Susquehanna River. NY 28—which overlaps with I-88 from Oneonta to exit 17 northeast of the city—leaves the freeway here, following NY 23 across the river to a large commercial district on the south bank. NY 28 leaves NY 23 here to proceed to the southwest while NY 23 goes eastward past several large strip malls and big-box retailers on its way out of both Oneonta and Otsego County.