Astra qualified for the UEFA Champions League, but were quickly eliminated by Danish side Copenhagen. Astra reached the play-off round of the 2016–17 UEFA Europa League and faced West Ham, which they also met – and defeated – one year prior. The club defeated West Ham 0–1 in London and reached the group stage of the Europa League, where they were drawn in Group E alongside Roma, Viktoria Plzeň and Austria Wien. Despite having zero points after two rounds, Astra Giurgiu managed to defeat Viktoria Plzeň and Austria Wien in away matches; this, in addition to a 0–0 draw with Roma and Austria Wien's failure against Plzeň secured Astra's place in the tournament's round of 32, where they faced Genk. A 2–2 draw at Giurgiu followed by a defeat, 0–1 in Belgium ended Astra Giurgiu's best European campaign in history.