The route is then concurrent with Interstate 80 eastward for approximately , passing just north of Rock Springs. US 191 diverges northward at Exit 104, following the former route of US 187. Traveling through high desert country, the route passes through Eden, Farson, and Pinedale before meeting US 189 at Daniel Junction. Continuing north, the road traverses increasingly mountainous terrain, entering the Bridger-Teton National Forest and passing through the small community of Bondurant before descending through the narrow Hoback River Canyon to an intersection with US 26 and US 89 at Hoback Junction. The route then follows the Snake River valley northward to Jackson. US 191 is concurrent with US 189 between Daniel Junction and Jackson, and with US 26 and US 89 between Hoback Junction and Jackson.