The most prominent highway passing through South Brunswick is a section of the New Jersey Turnpike (Interstate 95). This highway crosses the eastern part of the township, and a few ramps that lead to the toll gate for Interchange 8A pass through the township, with the majority of the interchange just outside the municipality's border in Monroe Township. Other major highways that the township also hosts include U.S. Route 1, U.S. Route 130, Route 27 and Route 32. A few county routes, such as 535 and 522, pass through the township.