During the years of the Polish–Lithuanian Commonwealth, in the area on the right bank of the River Neris opposite the St. Peter and St. Paul's Church in Antakalnis, a Royal Manor called "Derevnictva" (Polish: "Derewnictwo"), was established in the mid-16th century by King Sigismund Augustus as an outpost of the Vilnius Castles. The manor was held by the kings Sigismund III Vasa and Władysław IV Vasa, nobleman M. Piegłowski, the Wołowicz family, the Grand Hetman of Lithuania Michał Kazimierz Pac, as well by the Tyzenhaus family after 1741. In the mid-18th century, Lateran monks acquired the manor and named it "Tusculanum", after the resort outside the ancient Roman city of Tusculum. (see also: Villa Rufinella) The surrounding forests were used as a game reserve and for sport fishing. Towards the end of the century, the manor was separated into the folwarks of Tuskulėnai, based on the core of the old royal manor, and Derevnictva.