She then started an affair with Ryan McNeil, who at the time was married to Victoria Newman. Their relationship continued after Ryan and Victoria's marriage ended, and Nina ended up pregnant once again, leaving Ryan with no choice but to marry her. Nina miscarried, and it was then when Ryan realized how much he loved her. During their marriage though, Nina fell for Cole Howard, who incidentally was another one of Victoria's husbands. Cole didn't want to be with her and Nina was having hard time dealing with the truth, and her marriage to Ryan suffered because of it. Ryan fell for another woman, Tricia Dennison, and the feelings of rejection from both Cole and Ryan caused her to try to commit suicide. Ryan convinced her not to do this but a shot was fired and she lost her memory. She survived, however Ryan was believed to have shot Nina, who later regained her memory and told the police the truth.