At the Safe Zone, the pheromones of Kaine's Spider-Essence (from the Other) are recognized by Silk. After collaborating with the other spiders, it becomes clear that the Inheritors have mastered cloning technology, as they regenerate with the same memories into new cloned bodies (explaining Morlun twice returning after turning to dust, as most clones do). As Black Widow of Earth 1610 (Ultimate Peter Parker's female clone), Ben Reilly, and Kaine are all clones, they head the mission to Jennix's realm to infiltrate his cloning facility in the Baxter Building. After disabling that reality's Johnny Storm and Tony Stark, the clones then attempt to take on Jennix in the cloning facility. After Kaine killed Jennix with spikes coming from within, Jennix regenerated in the cloning caskets. After realizing that the top of the Baxter Building was the receiver that transferred the consciousness of deceased Inheritors into newly cloned bodies, Ben Reilly sacrificed himself to remove the Inheritors' safety net. After losing Ben Reilly a second time, Kaine began to feel the Other emerging and took off to Loomworld to face the Inheritors alone. While coming face-to-face with the Inheritors, Kaine had spikes emerge from his body and he killed Solus, the Patriarch of the Inheritors. In retaliation, Morlun killed Kaine in his "Other form" by ripping off one of his spider arms and impaling him in the skull. As the Inheritors require the Bride (Silk), the Scion (Benjy Parker from MC2/Earth 982) and the Other, which was Kaine, for the ceremony, Kaine's body was required for his blood to be used in the coming ritual.