Postrel was editor-in-chief of "Reason" from July 1989 to January 2000, and remained on the masthead as editor-at-large through 2001. Prior to that, she was a reporter for "Inc." and the "Wall Street Journal". She currently serves on the Board of Directors of the Foundation for Individual Rights in Education (FIRE). From 2000 to 2006, she wrote an economics column for the "New York Times" and from 2006 to 2009 she wrote the "Commerce and Culture" column for "The Atlantic". She also appeared on the last episode of the third season of Penn and Teller's "".