Mitsotakis was the first of four New Democracy members to announce their candidacy in the leadership election, declared following the resignation of Antonis Samaras as party leader and the failure of New Democracy in the September 2015 snap election. Amongst the other contestants was then-interim leader and former Speaker of the Hellenic Parliament Vangelis Meimarakis. According to the "Financial Times", Mitsotakis was "billed as an outsider in the leadership race" due to the party establishment's support of Meimarakis' candidacy. Following the first round of voting with no clear winner, Mitsotakis came second, 11% behind Meimarakis.