The eastern green mamba has the least toxic venom of the three green mamba species, but it is still highly venomous. Although the most commonly encountered green mamba, it generally avoids people. The peak period for bites is the species' breeding season from September to February, during which they are most irritable. A survey in southern Africa from 1957–1979 recorded 2,553 venomous snakebites, 17 of which were confirmed as eastern green mambas. Of these 17, 10 had symptoms of systemic envenomation, though no victims died. The snake tends to bite repeatedly, and one bite can contain 60–95mg of venom by dry weight. The median lethal dose (LD50) in mice is 1.3mg/kg through the subcutaneous route, and 0.45mg/kg through the IV route.