The first American settlers to Perry County arrived during the latter half of the 1790s and claimed rich land in Bois Brule Bottom. These Americans organized the region's original Baptist Church in 1807. In the early 19th century, a second group of American settlers crossed the Mississippi River to take advantage of Spanish land offers. These were Roman Catholics of English stock from north-central Kentucky. They had originally come from Maryland to escape religious discrimination and prided themselves on being descendants of Lord Baltimore's original colonists. The first of these to settle permanently in the future Perry County was Isidore Moore. He arrived in 1801 and became a patriarch of the area, and founded Tucker's Settlement. Others soon followed whose family names predominated the decades: Tucker, Fenwick, Cissell, Hayton, Riney, Hamilton, Layton, Manning, and Hagan. Most of these settled in the uplands around Perryville in a place called the Barrens because of its open land. Another Maryland Catholic, Joseph Fenwick, established the short-lived Fenwick Settlement at the mouth of Brazeau Creek in the Brazeau Bottoms.