Prior to the arrival of white settlers in mid-19th century, the Shasta people lived in the valley along Ashland Creek approximately where today's city is located. Early Hudson's Bay Company hunters and trappers following the Siskiyou Trail passed through the site in the 1820s. In the late 1840s, mainly American settlers following the Applegate Trail began passing through the area. By the early 1850s, the Donation Land Claim Act brought many to the Rogue Valley and into conflict with its native people. These often violent clashes, known ultimately as the Rogue River Wars, continued until 1856.