Slaton had one of the most memorable games in WVU football history in the next game versus Louisville. After trailing 17–0 at Halftime, Slaton and the Mountaineers rallied from a 24-7 4th Quarter deficit to win the game 46–44 in 3 overtimes. After kicking an onside kick that led to the tying score, the Mountaineers headed into overtime with the Cardinals. Slaton finished the game with 188 yards on 31 carries and 5 rushing touchdowns. Slaton also had his first receiving touchdown of the season. His six touchdowns are a WVU and Big East record. He was named the Walter Camp, USA Today, and Rivals.com national player of the week and was also named the Big East player of the week. Slaton added 71 yards on 17 carries in a nationally televised Big East game with Connecticut, but Slaton left the game early after an injury to his wrist.