Slaton and the Texans lost the following game against Baltimore 41-13. In the loss, Slaton rushed four times for seven yards and had two receptions for 17 yards in limited touches. However, Slaton rebounded in the following loss to the Indianapolis Colts, in which he posted career-high numbers - finishing the game with 14 carries for 156 yards and a touchdown. Slaton's yardage broke the franchise single-game rookie record, two yards shy of breaking Domanick Williams' all-time franchise record, while his 71-yard touchdown run was the longest rush in Texans' history. Slaton also led all rushers in the league with his performance. After the game, Slaton ranked first in most runs of 40 or more yards among the NFL's top 15 rushers, sixth in rushes of 20+ yards among the top 15, and his 5.1 yard per carry average was tied for second-most with DeAngelo Williams among the top 15. Then Slaton and the Texans defeated the Cleveland Browns 16-6, with Slaton leading the way with 21 rushes for 73 yards. Slaton and the Texans then defeated the Jacksonville Jaguars 30-17 on Monday Night. Slaton led the Texans' offensive assault with 21 carries for 130 yards with two touchdowns and was second on the team with two receptions for 52 yards - including a 46-yard screen reception. Slaton finished his first career Monday Night Football performance with 182 total yards of offense. For Slaton's Monday Night performance, he was awarded AFC Offensive Player of the Week for Week 14. Slaton went over 1,000 yards rushing on the season with his 120-yard, 26-carry performance against the Green Bay Packers in the 13th game of the season. Slaton also had 40 yards off of 3 receptions, totaling 160 yards of total offense. As the Texans then upset the Titans 13-12 the following week, Slaton posted a 100-yard performance off of 24 rushes.