The chemical messengers presumed to be responsible for mediating depolarization-induced suppression of inhibition was discovered by three separate groups in 2001. Wilson & Nicoll (2001) published their work in the prestigious journal, Nature, while the other two groups, Kreitzer & Regehr (2001) and Ohno-Shosaku "et al." (2001), published in the same issue of another reputable journal, Neuron. All three demonstrated heavy involvement of the CB1 cannabinoid receptor in depolarization-induced suppression of inhibition, suggesting that the endocannabinoids were the brain's mediators of depolarization-induced suppression of inhibition. They showed that cannabinoid receptor agonists, drugs that mimic the actions of endocannabinoids or THC, could evoke the same reduction in inhibitory currents caused by depolarization-induced suppression of inhibition. They also demonstrated that depolarization-induced suppression of inhibition could be prevented by cannabinoid receptor antagonists, drugs that block the actions of cannabinoid compounds.