Ramos received his first important recognition in the early 1960s; since 1959 he has participated in more than 120 group shows. Along with Roy Lichtenstein and Andy Warhol, he was one of the first artists to do paintings of images from comic books, and works of the three were exhibited together at the Los Angeles County Museum of Art in 1963. Along with Claes Oldenburg, James Rosenquist, Tom Wesselmann and Wayne Thiebaud, Ramos produced art works that celebrated aspects of popular culture as represented in mass media. His paintings have been shown in major exhibitions of pop art in the U.S. and in Europe, and reproduced in books, catalogs, and periodicals throughout the world.