Piggott is perhaps best known for its association with American writer and Nobel laureate Ernest Hemingway, whose second wife Pauline Pfeiffer was the daughter of prominent local landowner and businessman Paul Pfeiffer. After meeting and marrying in Paris in the late 1920s, Hemingway and Pauline made frequent and lengthy visits to her parents' home in Piggott, where Ernest Hemingway wrote portions of "A Farewell to Arms", and other works. The Pfeiffer House and Carriage House are now preserved as the Hemingway-Pfeiffer Museum and Educational Center, run by Arkansas State University.