From 1968 until 1975, "Dubuque" made five Western Pacific deployments that saw extensive duty in Vietnam. In a highly publicized event in October 1968, the ship returned 14 repatriated prisoners of war to North Vietnam. From 1969 until 1971 the ship conducted ten Operation Keystone Cardinal troop lifts to Okinawa as part of the withdrawal of US forces. "Dubuque" relieved as the launch platform for HMA-369's Marine Hunter-Killer (MARHUK) Operations near Hon La (Tiger Island) off the coast of North Vietnam. From February to June 1973 the ship operated helicopters that conducted naval mine clearance operations in Haiphong Harbor as part of Operation End Sweep. In April 1975 the ship participated in Operation Frequent Wind, the evacuation of Saigon and the rescue of refugees fleeing South Vietnam.