Leaving Rachel, SR 375 continues northwest to enter Nye County. The route climbs out of Sand Spring Valley and heads over the Queen City Summit, the highest point on the highway. After passing the summit, the route descends into the southern end of Railroad Valley, curving nearly due north for several miles as it follows the base of Reveille Range. As the mountains subside, the road turns westward again to head to its northern terminus at the junction of US 6 at Warm Springs.