Vani's good professional association with Vasant Desai resulted in her breakthrough with the film "Guddi" (1971) directed by Hrishikesh Mukherjee. Desai offered Vani to record three songs in the film amongst which the song "Bole Re Papihara", featuring Jaya Bachchan in the lead role, became a talk-of-the-town song and gave her instant recognition. Composed in Miyan Ki Malhar raag, the song showcased her classical prowess and subsequently fetching her many laurels and awards including the Tansen Samman (for best classical-based song in a Hindi film), the Lions International Best Promising Singer award, the All India Cinegoers Association award, and the All India Film-goers Association award for the Best Playback Singer in 1971. Her other song Humko Mann Ki Shakti Dena became a school prayer since the release of the song in 1971 and continues to be even now. She toured entire Maharashtra state accompanying her mentor, Desai, and taught many Marathi songs for school children.