Wilson made her screen debut reprising her stage role in the 1955 film adaptation of "Picnic" as Christine Schoenwalder. Additional films include "Patterns" (1956), "The Goddess" (1958), "The Tunnel of Love" (1958), "A Child Is Waiting" (1963, "The Birds" (1963), "The Graduate" (1967), "Jenny" (1970), "Catch-22" (1970) "Little Murders" (1971), "The Day of the Dolphin" (1973), "The Prisoner of Second Avenue" (1975), "9 to 5" (1980), "Grace Quigley" (1984), "Regarding Henry" (1991), "The Addams Family" (1991), and "Quiz Show" (1994). Her last film role was as Sara Delano Roosevelt in "Hyde Park on Hudson" (2012).