At the 2009 EuroBasket, Spanoulis averaged 14.1 points per game, and led Greece to the bronze medal. He was named to the All-Tournament Team. At the 2013 EuroBasket, despite playing most of the tournament with an ankle injury, Spanoulis was third in the tournament in scoring, averaging 16.7 points per game. During the tournament, he led Greece with a 20-point scoring performance, to a 79–75 victory over the world's 2nd ranked team in the FIBA World Rankings at the time, Spain. At the 2015 EuroBasket, Spanoulis led the Greek team, which had four players on it who had spent the 2014–15 season in the NBA (Giannis Antetokounmpo, Kosta Koufos, Nick Calathes, and Kostas Papanikolaou) in points per game and assists per game. Greece was ultimately defeated in the quarterfinals by Spain, by a score of 73–71, and finished the tournament in 5th place. After the tournament, Spanoulis announced his retirement from the Greek senior national team. He was Greece's leading scorer in every major FIBA tournament that he played in, from 2006 onward.