She began her career as a driver in Venezuela in 1996, finishing 2nd in the Venezuelan GT Championship. In 1998, Duno placed 4th in the Venezuelan Porsche Supercup Championship. In 1999, she moved to the United States and attended advanced racing schools and drove in the Barber Dodge Pro Series in 2000. Duno was the first woman in history to win a Ferrari Challenge Race in the USA and also she won her first Series Championship - The Panoz GT Series.