Already strained by the war, the relations of the "Diadochos" and his wife were clouded by their inability to give an heir to the Kingdom of Greece. Elisabeth became pregnant a few months after her marriage, but she suffered a miscarriage during an official trip to Smyrna. Deeply affected by her miscarriage, the crown princess became sick with typhoid soon followed by pleurisy and worsened by depression. She found refuge with her family in Bucharest, but despite the efforts of her mother and husband, neither Elisabeth's health nor her marriage fully recovered from the loss of her child.