In 2016, Jayawardene accompany with Sangakkara started a charity walkathon called "Trail as One" for raising money for a cancer hospital, which was the second trail after 2011. The walk started on 6 October 2016 from Point Pedro and finished at Dondra Head on 2 November 2016, which was 28-days 670 kilometres walk. Many other former and current Sri Lankan cricketers joined by each destination to the walk and the walk ended successfully with around US$5 million of money from all over the country. The money was given to expand the Karapitiya Teaching Hospital oncology unit in Galle.