After her strong first-year performance, Creamer was second behind Sörenstam in the inaugural Women's World Golf Rankings, which were released on February 20, 2006. Her 2006 season, however, was not as successful. She did not win a tournament, and was hampered by wrist and foot injuries during the year. Creamer still managed to earn over $1 million and make the cut in all 27 LPGA tournaments in which she played, compiling 14 top-10 finishes. Her best result of the season was a tie for second at The Mitchell Company Tournament of Champions.