In 1984, Edwards was assigned to a medical malpractice lawsuit that had been perceived to be unwinnable; the firm had accepted it only as a favor to an attorney and state senator who did not want to keep it. Nevertheless, Edwards won a $3.7 million verdict on behalf of his client, who had suffered permanent brain and nerve damage after a doctor prescribed an overdose of the anti-alcoholism drug Antabuse during alcohol aversion therapy. In other cases, Edwards sued the American Red Cross three times, alleging transmission of AIDS through tainted blood products, resulting in a confidential settlement each time, and defended a North Carolina newspaper against a libel charge.