Smitherman had also expressed interest in returning to provincial politics and reclaiming his former riding of Toronto Centre in the 2018 provincial election, which was vacant following the resignation of Glen Murray, but faced resistance from the leadership of the Liberal Party which considered him an unsuitable candidate for the party's nomination due to his association with the eHealth scandal as well as his reputation for being difficult and temperamental, and threatened to disqualify his candidacy. In the face of this opposition, Smitherman decided not to pursue the Liberal nomination and instead focus on his municipal campaign.