Adamek returned on 24 March 2012, after signing a contract with Main Events, defeating Nagy Aguilera by unanimous decision. He then agreed to face former heavyweight contender Eddie Chambers. Both Adamek and Chambers were praised for taking the fight with no world title nor mandatory position on the line. Coming into the fight, Adamek was ranked No.3 heavyweight contender by "The Ring", while Chambers, having had only one fight in two years and three months, was unranked by the publication. The fight was the main event of the Fight Night card on NBC Sports. In the opening rounds, both fighters were trading shots, with Chambers landing the most meaningful punches. During the first round, Chambers torn his bicep in the left arm, and often switched between orthodox and southpaw stances throughout the rest of the fight, throwing shots almost exclusively with the right hand, mostly connecting with overhand punches. Adamek was more active since round 3, frequently switching up from counterpuncher to aggressor. The bout lasted full twelve rounds, with Adamek being declared the winner by unanimous decision with scores 116–112 (twice) and 119–109. According to CompuBox, 1,381 punches were thrown, with Chambers landing 152 punches out of 462 thrown (32.9% accuracy), while Adamek landed 134 punches out of 919 (14.6%).