The Aetolians refused to participate in the Persian Wars. In 426 BC, led by Aegitios, they defeated the Athenians and their allies, who had turned against Apodotia and Ophioneia under the general command of Demosthenes. However, they failed to regain Naupaktos, which had meanwhile been conquered by the Corinthians with the aid of the Athenians. At the end of the Peloponnesian War, the Aetolians took part as mercenaries of the Athenians in the expedition against Syracuse. Then the Achaeans occupied Calydon, but the Aetolians recovered it in 361 BC. In 338 BC, Naupaktos was again taken by the Aetolians, with the help of Philip II. During the Lamian War, the Aetolians helped the Athenian general Leosthenes defeat Antipater. As a result, they came into conflict with Antipater and Craterus, taking great risks, but were eventually saved by the disagreement between the two Macedonian generals and Perdiccas. The Acarnanians then attempted to invade their land, but the Aetolians were able to force them to flee.