The novel is set in the 1680s and 90s in London and on the eastern shore of the colony of Maryland. It tells the story of an English poet named Ebenezer Cooke who is given the title "Poet Laureate of Maryland" by Charles Calvert. He undergoes many adventures on his journey to Maryland and while in Maryland, all the while striving to preserve his innocence (i.e. his virginity). The book takes its title from the grand poem that Cooke composes throughout the story, which was originally intended to sing the praises of Maryland, but ends up being a biting satire based on his disillusioning experiences.