Following the birth of her child, Mukerji took a four-year hiatus to focus on her daughter and was persuaded by her husband, Aditya Chopra, to return to acting. She was keen to work on a project that would accommodate her parental commitments and found it in the comedy-drama "Hichki" (2018). Inspired by Brad Cohen's autobiography "Front of the Class", the film tells the story of Naina Mathur, an aspiring teacher suffering from Tourette syndrome who must prove herself by educating underprivileged children. Mukerji interacted with Cohen and she trained to make her character's motor and vocal tics appear spontaneous and not rehearsed. In a mixed review, Anna M. M. Vetticad of "Firstpost" wrote that she "lifts "Hichki" every time she is on the scene, bringing empathy and charm to Naina's character without at any moment soliciting the audience's pity." It earned worldwide, a majority of which came from the Chinese box office, and its success led Mukerji to express an interest in working more frequently in the future. She gained another Best Actress nomination at Filmfare.