State Road 80's routing through downtown Fort Myers has changed a few times over the years. When designated in 1945, State Road 80 terminated at First and Fowler Streets (which carried US 41 when it crossed the Edison Bridge). SR 80 would be extended through downtown in 1964 when US 41 was rerouted over the Caloosahatchee Bridge (with First Street also carrying the U.S. Route 41 Business route concurrently). In the 1980s, SR 80 was split into one-way street pairs from Monroe Street to Palm Beach Boulevard and Seaboard Street, with eastbound traffic using Second and Seaboard Streets, and with westbound traffic using First and Bay Streets. The segment between Monroe and Fowler Streets was relinquished to the city of Fort Myers on January 11, 2006 as part of the downtown redevelopment and streetscape effort, creating the gap in the route that exists today.