It has been indicated that there is a "chicken and egg" issue in the study of models relating to epilepsy because on the one hand the models are used to study the genesis of epilepsy and on the other they are used to study changes in prolonged events. The question arises, therefore, of whether the resulting data of the models indicated an exaggerated defect responsible for the genesis of seizures or whether the data indicated systemic changes to normal tissue after prolonged seizure activity.