One year later, monster hunter Van Helsing kills Mr. Hyde after a brawl in Notre-Dame de Paris. Van Helsing suffers from amnesia, slaying evil on behalf of the Vatican City, hoping that he will earn redemption for forgotten sins. He is tasked by Cardinal Jinette to go to Transylvania and destroy Dracula. He must also protect the last members of an ancient Romanian family, the Valerious, whose ancestor vowed that his descendants would kill Dracula, or fall into Purgatory. He receives a torn parchment, reading "In the name of God, open this door" in Latin.