The population reached 454 in 1920 and 500 in 1925. By that time, the community was served by some 25 businesses, including a bank, and by two schools with a combined enrollment of 300 students. Pottsboro declined to a population of 358 by 1936 and 312 by the mid-1940s. It then grew to 383 by 1957. The number of businesses had fallen to 12 by 1948, though by the late 1950s, it was back up to more than 20. The town began to grow again during the 1950s, perhaps spurred by the rapid expansion of nearby Denison. By 1967, Pottsboro reported 30 businesses and a population of 750, and by 1990, its population was 1,177. The population grew to 1,579 in 2000.