In 1679, at age fifteen, Ruysch was apprenticed to Willem van Aelst, a prominent flower painter in Amsterdam. His studio in Amsterdam looked out over the studio of the flower painter Maria van Oosterwijck. Ruysch studied with van Aelst until his death in 1683. Besides painting technique he taught her how to arrange a bouquet in a vase so it would look spontaneous and less formalized. This technique produced a more realistic and three-dimensional effect in her paintings. By the time Ruysch was eighteen she was producing and selling independently signed works. She would also have known and consorted with the flower painters Jan and Maria Moninckx, Alida Withoos, and Johanna Helena Herolt-Graff, who all were about her age and who worked for the hortus owner Agnes Block and who, like her father, also worked with the plant collectors Jan and Caspar Commelin.