DFSS for software is essentially a non superficial modification of ""classical DFSS"" since the character and nature of software is different from other fields of engineering. The methodology describes the detailed process for successfully applying DFSS methods and tools throughout the software product design, covering the overall Software Development life cycle: requirements, architecture, design, implementation, integration, optimization, verification and validation (RADIOV). The methodology explains how to build predictive statistical models for software reliability and robustness and shows how simulation and analysis techniques can be combined with structural design and architecture methods to effectively produce software and information systems at Six Sigma levels.