Shortly after the interchange with I-695, MD 144 enters the city of Baltimore, where it continues as Frederick Avenue. The state highway passes Baltimore National Cemetery, Mount Saint Joseph College high school, the Schwartze Mansion, and Loudon Park National Cemetery in an affluent residential area. MD 144 expands to a four-lane undivided highway at Beechfield Avenue before reaching Hilton Street and Caton Avenue, where the highway crosses over Amtrak's Northeast Corridor. The state highway continues east through a less affluent series of neighborhoods where it crosses over Gwynns Falls and CSX's Hanover Subdivision. East of Bentalou Street, MD 144 splits into a one-way pair, with the eastbound lanes following Pratt Street and the westbound lanes following Frederick Avenue and then Lombard Street. The state highway intersects US 1 at its own one-way pair, Monroe Street southbound and Fulton Avenue northbound. Both directions of MD 144 have their eastern terminus at Fulton Avenue, although Frederick Avenue itself continues two more blocks to its own terminus at Baltimore and Gilmor Streets. Both Pratt Street and Lombard Street continue east toward downtown Baltimore, passing through the Union Square neighborhood and by the Mount Clare Shops and the B&O Railroad Museum.