Nomadic Native Americans arrived in the lower reaches of Fishing Creek around 8000 BCE, and some were spending winters in the upper reaches of the valley by 3000 to 2000 BCE. In the past few centuries, the Fishing Creek area has been home to many industries, mills, and dams. It drains parts of five Pennsylvania counties: Columbia, Montour, Sullivan, Luzerne, and Lycoming. The creek's main tributaries include Hemlock Creek, Little Fishing Creek, Green Creek, Huntington Creek, West Branch Fishing Creek, and East Branch Fishing Creek.