On the September 23 episode of "Raw", Mysterio won a fatal five-way elimination match, which led to Mysterio earning a Universal Championship opportunity against Seth Rollins. However, the following week on "Raw", Mysterio and Dominik was brutally attacked by Brock Lesnar, resulting in a storyline injury for the latter. On the October 4 episode of "SmackDown", Mysterio assisted the debut of Cain Velasquez to attack Lesnar after the latter's WWE Championship win. At Crown Jewel, Lesnar defeated Velasquez by submission and continued to apply the Kimura Lock after the match had concluded until Mysterio attacked Lesnar with a chair. On the following week, Lesnar quit SmackDown to move to Raw in order to seek revenge against Mysterio, who had been drafted to Raw. At Survivor Series, Mysterio lost to Lesnar despite interference from Dominik.