Mexborough Interchange was built by the South Yorkshire Passenger Transport Executive in the early 1990s, replacing bus stops in both directions on the High Street which was subsequently pedestrianised. When the Interchange first opened, there was a manned ticket office and indoor waiting area with toilet facilities located in a small building between the Greens Way stands and John Street. However, around the time of the beginning of the Great Recession, the manned ticket office was closed and all facilities inside were sealed off as an austerity measure. As of early 2021, Travel South Yorkshire are still looking to dispose of the former ticket office building as evidenced by the persistent "to let" signs affixed to its exterior, although it has never yet seen any further use since closure.