Route 146 is a state-designated scenic road, beginning from its western terminus in Branford, near Church Street and continuing for the remainder of the route. The section in Branford is also designated the Edward Ramos Memorial Highway, in honor of a Branford firefighter who died in the line of duty. The road and the adjacent properties from Flat Rock Road in Branford to the West River in Guilford has been designated as a historic district on the National Register of Historic Places known as Route 146 Historic District.