Collette Sunderman was the casting and recording director for the show. Sean Marquette was cast as Mac, and Keith Ferguson was cast as Bloo. "The Powerpuff Girls" voice actors Tom Kane, Tom Kenny and Tara Strong were cast in "Foster's" as Mr. Herriman, Eduardo and Terrence, respectively. Grey DeLisle was cast as Frankie Foster, Phil LaMarr was cast as Wilt, and Candi Milo was cast as Coco and Madame Foster. From season two onwards, Milo also lent her voice to Cheese. DeLisle also voiced Goo after the character's debut in season three.