Isaac played X-Men villain Apocalypse in the film "", which was released on May 27, 2016. Also that year, he played the lead role in the historical drama "The Promise", with co-star Christian Bale, in a story about the Armenian Genocide. He was the narrator for the Nike ad "Unlimited You" created by Wieden+Kennedy. In November 2016, the first episode of the podcast series "Homecoming" was released. It is a six-episode psychological thriller from Gimlet Media, co-starring Catherine Keener and David Schwimmer; Isaac voices a soldier trying to rejoin civilian life.