West of I-79, PA 65 continues to parallel the Ohio River located to the south. Along the way, PA 65 passes through some boroughs like Haysville and Osborne. In the borough of Sewickley, PA 65 meets the long Orange Belt at Broad Street which crosses the Ohio River on the Sewickley Bridge and has direct access to PA 51. Leaving Sewickley, PA 65 crosses two more broughs (Edgeworth and Leetsdale) before exiting Allegheny County. In Leetsdale, PA 65 meets the first terminus of the Red Belt at an intersection involving Cross Street.