Ardoin strained his left knee while tagging out Los Angeles Dodgers outfielder José Cruz, Jr. on a play at home plate, and he was placed on the disabled list on May 27. Closser was recalled from the Rockies' Triple-A affiliate to fill in during Ardoin's absence. When Ardoin returned from his injury, the Rockies optioned Closser back to Triple-A; however, after being back with the Rockies for five games, Ardoin was designated for assignment on August 25, 2006, clearing a roster spot for rookie prospect Chris Iannetta.