The area that would later become the city of Ennis was first inhabited by the Tonkawa Native Americans. The area was also the hunting grounds of several Native American tribes including the Waco, Bidai, Anadarko, and Kickapoo tribes. These tribes frequented the area until Anglo pioneers arrived in the early-to-mid 19th century. When Ellis County was established and organized in 1850, much of the area was sparsely inhabited by isolated farmsteads as the nearby city of Dallas was in its infancy at the time. However, communities such as Ovilla, Waxahachie, and Burnham would have been settled and founded prior to the establishment of the city of Ennis.