In the Spurs' season opener on October 25, 2016, Aldridge recorded 26 points and 14 rebounds in a 129–100 win over the Golden State Warriors. His next best performance came on December 25 against the Chicago Bulls. Aldridge had a season-high 33 points in a 119–110 win over the Bulls, marking his second-highest scoring output as a Spur. He made his first nine attempts while scoring 20 points in the opening period, his most in any quarter with the Spurs. On March 11, 2017, he was ruled out for an indefinite period due to an occurrence of a minor heart arrhythmia. He was medically cleared to return on March 15. In his first game back that night, Aldridge had 19 points and seven rebounds in a 110–106 loss to the Portland Trail Blazers. As a result, Aldridge reached 1,000 points for a 10th straight season, joining LeBron James and Dwyane Wade as the only active players (at the time) with that streak.