In 1818, he formed the business, trading and shipping firm "Jamsetjee Jejeebhoy & Co." with two other associates Motichund Amichund and Mahomed Ali Rogay as Jejeebhoy's business associates. He was later joined by a Goan Rogério de Faria. His voyages to China resulted in a long trading partnership with the Canton based company Jardine Matheson & Co. The connection with Jeejeebhoy was instrumental as Jardine and Matheson built up their great firm, continuing the profitable and amiable association with the Parsi entrepreneur. Jeejeebhoy long continued as one of the close associates who served as underwriters to Jardine, Matheson and Company. A tribute to their connection exists even today in a portrait of Jeejeebhoy which hangs in Jardine's Hong Kong office. He was seen as the chief representative of the Indian community in Bombay by the British Imperial authorities.