DeJoria co-founded the Patrón Spirits Company in 1989, is a founding partner of the House of Blues nightclub chain, and has interests in Madagascar Oil Ltd., Pyrat Rum, Smokey Mountain Bison Farm, llc, Ultimat Vodka, Solar Utility, Sun King Solar, Touchstone Natural Gas, Three Star Energy, Diamond Audio, a Harley-Davidson dealership, a diamond company (DeJoria), mobile technology developer ROK AMERICAS, the John Paul Pet Company which does hair and personal grooming for animals, and J&D Acquisitions LLC, the parent company for the Larson, Striper, Triumph, Marquis and Carver boat companies formed with Minneapolis-based investor Irwin L. Jacobs. In 2008, DeJoria became an advisory board member for The Beauty Channel; a streaming beauty and fashion-focused television station.