"Macho Women with Guns" is set in a near-future America where society has collapsed due to the misdeeds of the Reagan administration. Taking advantage of the earthly chaos, Satan has dispatched her female minions, the Batwinged Bimbos From Hell, to rebuild society in a form she approves of. The Vatican has responded to Satan's plans by dispatching its elite group of warrior nuns, The Sisters of Our Lady of Harley-Davidson to combat the bimbos. The two groups of women compete (sometimes violently) to rebuild civilization by vanquishing post-apocalyptic menaces and male chauvinism.