PMHS is the home of the Comets sports teams, who compete in section 1 of the Lancaster-Lebanon League. Penn Manor athletic teams have won four state championships. The girls' soccer team won the state title in both 2002 and 2005, and the boys' baseball team was the state champion in 2005. The girls' field hockey team won the state championship in 2008. The class of 2004's baseball team was the first to achieve a sectional championship since 1979. In addition, the wrestling team achieved section champions in 2006.