Yvel then faced Jon Madsen on October 23, 2010 at UFC 121, replacing an injured Todd Duffee. Both men circled early on in the fight before Madsen shot for a double-leg takedown that downed Yvel after Gilbert slipped when his knee buckled, they ended up against the cage. Madsen then hit Yvel multiple times when Yvel's head was pressed up against the Octagon padding, resulting in the referee stopping the fight. Yvel was subsequently released from his UFC contract after the loss.