State Route 375 (SR 375) is a state highway in Nye and Lincoln counties in south-central Nevada, United States. The highway stretches from State Route 318 at Crystal Springs northwest to U.S. Route 6 (US 6) at Warm Springs. The route travels through mostly unoccupied desert terrain, with much of its alignment paralleling the northern edges of the Nellis Air Force Range. The road originally traversed through what is now the northern reaches of the air force range in the 1930s, when it was previously designated State Route 25A and later part of State Route 25.