The Karnatak University took over the college in 1958, to be run as a model college, for administrative convenience. Late Prin. G.S. Paramasiviah was the first Principal of the bifurcated science college, and served as Principal from 1958 to 1968. Dr. J C Uttangi (1968-1976), Prof. H R Ladwa (1976-1981), Dr. N L Dipali (1981-1992) & Prof. R S Bhoosnurmath (1994-1998) are some of the stalwarts who occupied the post of Principal of Karnatak Science college, Dharwad. Presently, Dr. C.F. Mulimani, Criminology and Forensics Science, is the principal.