In the mid to late 1800s, a series of major epidemics hit the area. A particularly bad one occurred in the early winter of 1868. Cases of smallpox were reported among the poor of San Juan Bautista. Efforts were made to localize the rapidly spreading disease, such as, barricading the roads leading in and out of San Juan Bautista. These efforts failed however, and when cases appeared in Watsonville, Santa Cruz citizens attempted to again quarantine the disease by destroying the Aptos Bridge. These efforts again failed and only created a rift between the two cities. The death toll of the smallpox epidemic lead to the local press publishing of the latest remedies available for home use as well as methods to prevent the spread of smallpox and inoculations.