She played her first leading role, as a bold dance teacher, in the 2006 film "Aanachandam"; it was a highly unsuccessful venture, which went unnoticed soon after its release. Regarding to her performance in the film, a critic from "Rediff" noted that she was "refreshing in bits", while another reviewer cited that she was "refreshing enough for a village based film". Her subsequent projects, "Changathipoocha" (2007) and "Panthaya Kozhi" (2007) released to mixed reviews and offered hardly any scope for her, failing to propel her career. The next release, "Chocolate" (2007), which featured Remya as one of three leading females, gained her considerable attention, after the film went on to become a high commercial success. In 2008, she accepted her first non-Malayalam project, "Andamaina Mansulo" in Telugu, which was followed by her first Tamil film, the romantic drama "Raman Thediya Seethai". "Anthiponvettam" was her only Malayalam film of 2008, which opened to largely negative reviews, while Remya received positive feedbacks on her performance, with a critic from "IndiaGlitz" describing her as "a saving grace in the entire movie". In the following two years, she appeared in just three films. She played the female lead in "Saarai Veerraju" (2009; Telugu) and "Aattanayagann" (2010; Tamil) and played a minor supporting role in "Nammal Thammil" (2009; Malayalam) —all of which proved critically and commercially unsuccessful, although her performance in the former was lauded. "IndiaGlitz" claimed that she was the "best performer" in the film, further adding that she had "raised to the occasion and carried the deglamorised role perfectly".