Returning to Parliament in 1818, he argued against the Royal Households Bill and introduced a Game Law Amendment Bill, which was defeated. Following the Peterloo Massacre and the government's introduction of a Seditious Meetings Prevention Bill, Coke accused the government of being "most strongly implicated in the events in Manchester", saying that the meeting would have been peaceful had it not been "interfered with by the officious agents of authority". The 1820s saw Coke speak far less; firstly, because of the continued Tory domination of Parliament, and secondly because of his remarriage. In 1822, at the age of 68 and after 21 years as a widower, he married Anne Keppel, the daughter of Lord Albemarle, and Coke's 18-year-old godchild. Anne had initially been brought to Holkham to partner with his nephew William, who due to Coke's lack of sons would inherit the estate, but they failed to get on. Anne and Coke's marriage was met with bemusement, and described as "absurd", but despite opposition took place on 26 February. Soon after the wedding Anne became pregnant, and their son Thomas was born on 22 December.