Without his Scarlet Spider outfit, Kaine finds himself face-to-face with Ana Kravinoff, who tries to kill Kaine before informing him that her father Kraven the Hunter is coming for him and there is nothing he can do. Madame Web's vision at the end of the issue confirms that dark times are coming for Kaine as the Kravens plan their next move. Later, he gets involved with Roxxon Energy Corporation after the daughter of the CEO blows up the top floor of Roxxon's office building with a missile. In his investigation of the events, he storms the CEO's offices and ends up fighting the hero team Rangers. He later allies with them when they discover that Roxxon had accidentally released an energy being from the ground in one of their oil platforms; to contain it, the company had acquired the services of human smugglers (the Lobo Cartel) to feed the beast with human sacrifices.