In 1959 Humphries moved to London, where he lived and worked throughout the 1960s. He became a friend of leading members of the British comedy scene including Dudley Moore, Peter Cook, Alan Bennett, Jonathan Miller, Spike Milligan, Willie Rushton and fellow Australian expatriate comedian-actors John Bluthal and Dick Bentley. Humphries performed at Cook's comedy venue The Establishment, where he became a friend of and was photographed by leading photographer Lewis Morley, whose studio was located above the club. He contributed to the satirical magazine "Private Eye", of which Cook was publisher, his best-known work being the cartoon strip "The Wonderful World of Barry McKenzie". The bawdy cartoon satire of the worst aspects of Australians abroad was written by Humphries and drawn by New Zealand born cartoonist Nicholas Garland. The book version of the comic strip, published in the late '60s, was for some time banned in Australia.