NY 52 Business begins at I-84 / NY 52 exit 11 and runs concurrent with NY 9D into Beacon. At Main Street, NY 52 Business leaves NY 9D and follows Main Street east through the Lower Main Street Historic District and across town to Fishkill Avenue. The route turns left onto that street, following Fishkill Avenue out of the city. At Prospect Street, a local road straddling the Beacon city line, NY 52 Business becomes state-maintained as NY 980J, an unsigned reference route.