Peirce is the creator of the comic strip "Big Nate". The strip debuted in 1991 in 135 newspapers, and currently has a client list of over 400 newspapers worldwide.  "Big Nate" is also available online at gocomics.com, where in 2019 it was the site's second most-viewed feature, ranking behind only "Calvin & Hobbes".  The popular children's website poptropica.com has included "Big Nate" since 2009.  In 2010, Peirce wrote the first of eight "Big Nate" novels for young readers.  Published by HarperCollins, each book in the series was a New York Times bestseller. In 2011, Andrews McMeel Publishing began a series of "Big Nate" compilations. The series consists of 22 books to date and every one of them has been on the New York Times bestseller list. Under the AMP! Comics for Kids imprint, twenty collections have been released.  "Epic Big Nate", a coffee table book celebrating the strip's first 25 years, was published in 2016.  "Big Nate" books appear in 33 different languages and have sold over 20 million copies.