Alzheimer's disease is the most common form of dementia, and studies have shown that manipulation of pathways involving LRP8/ApoER2 can lead to the disease. Certain alleles, such as apoe, app, ps1 and ps2, may lead to being genetically predisposed to the disease. A decrease in LRP8 expression is observed in patients with Alzheimer's disease. An example of a decrease in expression of LRP8 is when gamma secretase cleaves LRP8 as well as the ligand amyloid precursor protein (APP). The degradation products control transcription factors, which lead to the expression of a tau protein. The cascade dysfunction caused by the altered gene expression may be implicated with Alzheimer's disease.