The 1926 St. Louis Cardinals season was the team's 45th season in St. Louis, Missouri and their 35th in the National League. The Cardinals went 89–65 during the season and finished first in the National League, winning their first National League pennant. In the World Series, they defeated the New York Yankees in 7 games, ending it by throwing out Babe Ruth at second base in the ninth-inning of Game 7 to preserve a 3–2 victory. This was Rogers Hornsby's only full season as manager for the team.