Reflecting its changing mission, the Massachusetts General Court renamed Tewksbury Almshouse to Tewksbury State Hospital in 1900. Tewksbury was to be renamed three times over the next century: to Tewksbury State Infirmary in 1909, to Tewksbury State Hospital and Infirmary in 1939, and finally to Tewksbury Hospital in 1959, the name it still bears. In the first part of the 20th century, Tewksbury combined two roles, first, as a "last resort" facility for the elderly and the mentally ill, and secondly, as an isolation and care center for patients with infectious diseases, such as Smallpox, Typhoid Fever, and Tuberculosis.