It heads west from US 181 through Corpus Christi and intersects two freeways, SH 286 (the Crosstown Expressway) and SH 358 (Padre Island Drive). The highway turns towards the northwest after the SH 358 interchange roughly parallel to the south of the Nueces River. Just prior to leaving the Corpus Christi city limits, it intersects and has a short concurrency with US 77 (future I-69E). US 77 (future I-69E) merges with I-37 as a freeway from the south; the two continue to the north and split after crossing the Nueces River. The Interstate continues to the northwest as US 77 (future I-69E) continues to the northeast.