Present-day Cortez was a part of the Safety Harbor culture region from about 900 CE until the 1700s. The Safety Culture people formed chiefdoms and villages along the shoreline of Tampa Bay and the adjacent Gulf of Mexico coast. Safety Harbor culture is defined by the presence of Safety Harbor ceramics in burial mounds, which have been excavated from nearby archaeological sites in present-day Manatee County. The Safety Harbor culture virtually disappeared due to disease and incursions by other Native Americans.