In 1953, EC Comics—which in the 1950s produced a number of horror and dramatic titles later considered to be classics of the field—recruited Wessler, Jack Oleck, Daniel Keyes, and other writers. Wessler contributed a large number of stories to EC's famed horror titles "Tales from the Crypt", and "The Vault of Horror"—writing the entirety of "Tales from the Crypt" #45 (Jan. 1955), for instance, with the artists including Graham Ingels, Jack Davis, Jack Kamen, and Bernard Krigstein. He wrote as well for EC's "Aces High", "Crime SuspenStories", "Impact", "Piracy", "Shock SuspenStories" and "Weird Science-Fantasy".