The arrangements of 299 lasted until the mid-330s, when Shapur II began a series of offensives against the Romans. Despite a string of victories in battle, culminating in the overthrow of a Roman army led by Constantius II at Singara (348), his campaigns achieved little lasting effect: three Persian sieges of Nisibis, in that age known as the key to Mesopotamia, were repulsed, and while Shapur succeeded in 359 in successfully laying siege to Amida and taking Singara, both cities were soon regained by the Romans. Following a lull during the 350s while Shapur fought off nomad attacks on Persia's eastern and then northern frontiers, he launched a new campaign in 359 with the aid of the eastern tribes which he had meanwhile defeated, and after a difficult siege again captured Amida (359). In the following year he captured Bezabde and Singara, and repelled the counter-attack of Constantius II. But the enormous cost of these victories weakened him, and he was soon deserted by his barbarian allies, leaving him vulnerable to the major offensive in 363 by the Roman Emperor Julian, who advanced down the Euphrates to Ctesiphon with a major army. Despite victory at the Battle of Ctesiphon before the walls Julian was unable to take the Persian capital and retreated along the Tigris. Harried by the Persians, Julian was killed in the Battle of Samarra, during a difficult retreat along the Tigris. With the Roman army stuck on the eastern bank of the Euphrates, Julian's successor Jovian made peace, agreeing to major concessions in exchange for safe passage out of Sasanian territory. The Romans surrendered their former possessions east of the Tigris, as well as Nisibis and Singara, and Shapur soon conquered Armenia, abandoned by the Romans.