Spillane made his debut on the inter-county scene at the age of sixteen when he was picked on the Kerry minor team. He enjoyed two championship seasons with the minor team, however, he was a Munster runner-up on both occasions. Spillane subsequently joined the Kerry under-21 team, winning back-to-back All-Ireland medal in 1975 and 1976. By this stage he had also joined the Kerry senior team, making his debut during the 1973–74 league. Over the course of the next seventeen years, Spillane won eight All-Ireland medals, beginning with a lone triumph in 1975, a record-equalling four championships in-a-row from 1978 to 1981 and three championships in-a-row from 1984 to 1986. He also won twelve Munster medals, two National Football League medals and was named Footballer of the Year in 1978 and 1986. He played his last game for Kerry in August 1991. Spillane was joined on the Kerry team by his two brothers, Mick and Tom, and together won a total of 19 All-Ireland medals – a record for a set of brothers.