Philip Winthrop (Mark Damon) travels to the House of Usher, a desolate mansion surrounded by a murky swamp, to see his fiancée Madeline Usher (Myrna Fahey). Madeline's brother Roderick (Vincent Price) opposes Philip's intentions, telling the young man that the Usher family is afflicted by a cursed bloodline which has driven all their ancestors to madness and even affected the mansion itself, causing the surrounding countryside to become desolate. Roderick foresees the family evils being propagated into future generations with a marriage to Madeline and vehemently discourages the union. Philip becomes increasingly desperate to take Madeline away; desperate to get away from her brother, she agrees to leave with him.