"Give Up the Funk" appears throughout the 2012 episode "Charlie's Mom Has Cancer" from the eighth season of "It's Always Sunny in Philadelphia". It first appears when the Gang go to visit Dr. Jinx (Puff Daddy). He is listening to it in his home/garage/doctor's office, then plays the main melody on a bass guitar when Dennis asks him if he "has anything that could cause him to have feelings again". Finally, Dr. Jinx's band, Dr. Jinx, is seen performing near the end of the episode at the Gang's "Beef, Beer & Jesus" benefit for Charlie's mom at Paddy's Pub.