Martin Lodewijk was born in Rotterdam. He dropped out of high school in 1957, and started drawing cartoons, notably of spacecraft and pirates. In 1959, his first cartoon was published in the newspaper "Het Parool", after which he specialized in drawing for commercial advertising. For the weekly comics magazine "Pep", he co-created with Jan Kruis the "Agent 327" comic in 1966, a feature he ended up writing and drawing for close to fifty years. He provided scripts for other strips, such as Don Lawrence's "Storm". After "Pep" and "Sjors" merged into "Eppo", Lodewijk became "Eppo"'s chief editor.