On May 5, 2018, Longoria hit a double to mark his 1,500th career hit in an 11–2 victory over the Atlanta Braves. On June 14, Longoria was hit by a pitch on his left hand and left the game. Soon after, it was revealed that there was a fractured fifth metacarpal in his left hand. Two days into his injury, it was revealed that Longoria was facing surgery, which would likely keep him out for 6–8 weeks. Longoria experienced a disappointing 2018 season with the Giants as he hit a career-low 16 home runs (which led the Giants), had a career low in runs batted in with 54 and tied his career low with a .244 batting average.