During his senior men's playing career, Zisis won the 2008 EuroLeague championship, while a member of CSKA Moscow. Zisis also won 9 national league championships in various European domestic leagues (four Italian League titles, two Russian League titles, two German League titles, and one Greek League title). In addition to that, he also won 8 national cup titles (four Italian Cups, two German Cups, one Russian Cup, and one Greek Cup). Two of his club teams, XAN Thessaloniki and Brose Bamberg, retired his team jerseys.