In 1758, Catherine and her husband moved to America, and in 1759 Charke attempted to return to the stage in the breeches role of Marplot in Susanna Centlivre's "The Busybody." With her father dead, her family members gone, and her daughter Kitty abroad in New York, Charlotte, again, was alone. In mid-April 1760, at the age of forty-seven, Charlotte fell ill with a "winter disease" and was never able to recover from it. She died that year at her Lodgings in Haymarket, London, with only the remembrance of being "the celebrated Mrs. Charlotte Charke, Daughter of the late Colley Cibber, Esq., Poet Laureat; a Gentlewoman remarkable for her Adventures and Misfortunes."