Sometime afterward, Rogers avoids the explosion of a methamphetamine lab, but the drug triggers a chemical reaction in the Super Soldier Serum in his system. To combat the reaction, Rogers has the serum removed from his body and trains constantly to maintain his physical condition. A retcon later establishes that the serum was not a drug "per se", which would have metabolized out of his system, but in fact a virus-like organism that effected a biochemical and genetic change. This additionally explained how nemesis the Red Skull, who at the time inhabited a body cloned from Rogers' cells, has the formula in his body.