In the "What If?" storyline "What if the Alien Costume had Possessed Spider-Man?", after the symbiote forms a permanent bond with Spider-Man due to Mister Fantastic being unable to examine the web-slinger until it is too late to break them apart, Felicia goes on a brief crime spree until she learns that the symbiote—which here lives on adrenaline from superhumans—has abandoned the now-deceased Spider-Man in favor of the Hulk; she favors killing the Hulk over the objections of the other heroes. After Spider-Man's funeral, she is contacted by the Kingpin, who helps her develop a weapon that will kill the symbiote in exchange for a lifetime of service from her; despite the heroes having already defeated the symbiote thanks to the actions of Thor and Black Bolt, with Doctor Strange being about to banish it, Felicia kills the symbiote anyway, subsequently berating the heroes for not knowing the price she had to pay to ensure that justice was done.