Following a late call up to the Great Britain squad, in July 2010 he won silver at the 2010 European Athletics Championships in a time of 10.18 seconds, his first major individual medal at senior level. Unfortunately, three days later in a heat of the 4 × 100 m relay, he blundered during the baton exchange that resulted in the team not making the final. Nonetheless, he was selected to represent Europe at the 2010 IAAF Continental Cup and he took the bronze medal while European champion Christophe Lemaitre won the race. Lewis-Francis gained a second silver of the season at the 2010 Commonwealth Games: he recorded a season's best run of 10.15 seconds in the qualifiers and he ran 10.20 seconds to finish as runner-up behind Lerone Clarke in the final, having pulled himself back into contention after his starting blocks slipped.