Meazza was born in Porta Vittoria, Milan. Having lost his father in 1917 during the fighting of World War I at the age of seven, Peppe grew up in Milan with his mother, Ersilia who came from Mediglia, helping her sell fruit at the market. He began playing football at six years old, and started out playing barefoot with a ball made of rags on the streets for a team named the "Maestri Campionesi". At the age of twelve, his mother gave him permission to pursue a footballing career, and he began playing for Gloria F.C.. It was during this time that a fan gave Meazza his first pair of football boots.