In 1950, Biggers won first prize for his painting "The Cradle" at the annual exhibition at the Museum of Fine Arts in Houston. "Segregationist policies, however, allowed black visitors into the museum only on Thursdays, so he could not attend the show's opening." From 1950 to 1956 Biggers painted four murals in African-American communities in Texas, the beginning of his work in murals. He painted many public murals in Houston and elsewhere, including two in 1991 for Winston-Salem State University in North Carolina. Most are still in place.