To both avenge a Japanese girl who was murdered by her captors and the criminals behind the treatment of Aracely, Kaine investigates and attempts his best to stop human smuggling operations running through Houston. Shortly after, Aracely starts to manifest weird dreams concerning the Sixth Creation, Aztlan, her missing parents, gods, a talking coyote and the Rise of Mictlan. Taking a stroll through the park to discuss this strange change, she and Kaine are attacked by the Lobo - drug crime leaders, the human smugglers behind Aracely's abduction and werewolves sent with the intent of killing her by the mysterious Mr. Moctezuma so "the Sixth Creation could begin". During the fight Aracely escapes but Kaine is beaten and eventually killed. However, in death he encounters Ero, from "" story arc, who states she can return him to life only if he embraces the other. Kaine at first rejects Ero but realizes that Aracely still needs his help, so he agrees. In the real world, Kaine bursts out of a web cocoon, reborn not as before, but as a monstrous spider-creature. The spider-creature Kaine maims one of the two werewolves, forcing them to flee. He then attacks Aracely until she is able to use her mental powers to bring him back. Kaine breaks out of the husk of the spider-creature completely healed of all scars but still carrying the Other inside him. It is then that Aracely proclaims him as her "champion", a title that is not merely affective but also has a deeper meaning as hinted by her father's words and the strange portents with cryptic Aztec mythic symbolism in her dreams.