The church is prominently featured in the Clint Eastwood movies "Dirty Harry" (the Church, and nearby Dante Building, are the scene of sniper attacks by the "Scorpio Killer") and "The Dead Pool". Scenes from Cecil B. DeMille's 1923 version of "The Ten Commandments" were filmed at the church while it was under construction. Also featured in "What's Up, Doc?" in which Judy Maxwell, portrayed by Barbra Streisand and Dr. Howard Bannister, portrayed by Ryan O'Neal borrowed a Volkswagen Beetle during a car chase. Parts of "Sister Act 2" were also filmed here.