The highway begins in Corpus Christi at US 181 and SH 35 and heads north to San Antonio, where it ends at I-35. Beyond I-35, the freeway continues as US 281 to northern San Antonio as a major freeway. In Corpus Christi, the highway provides access to the downtown area, the Port of Corpus Christi, and the Corpus Christi International Airport. In San Antonio, it provides access to Downtown, Brooks City-Base, the Alamodome, the Tower of the Americas, the River Walk, the Alamo, and by extension via US 281, the San Antonio International Airport. The route provides an important connection between I-35 and the Texas Gulf Coast as well as one of the few limited-access hurricane evacuation routes away from the southern Texas coast.