Humphries has been married four times. His first marriage, to Brenda Wright, took place when he was 21 and lasted less than two years. He has two daughters, Tessa and Emily, and two sons, Oscar and Rupert, from his second and third marriages, to Rosalind Tong and Diane Millstead respectively. His elder son Oscar was editor of the art magazine "Apollo" and a contributing editor at "The Spectator". He is now an art curator. His fourth wife (from 1990), Elizabeth "Lizzie" Spender, previously an actor, is the daughter of British poet Sir Stephen Spender and the concert pianist Natasha Spender. They live in a terraced town house in West Hampstead, his home for forty years.