The story begins with the player character (PC), the protagonist of the story, being sent to recover four creatures (dryad, intellect devourer, yuan-ti, and cockatrice) known collectively as the "Waterdhavian creatures" under the guidance of Lady Aribeth de Tylmarande. The Waterdhavian creatures are needed to make a cure for the Wailing Death, a plague that is sweeping the city of Neverwinter and forcing a quarantine. With the help of Fenthick Moss, Aribeth's love interest, and Desther, Fenthick's friend, the PC is able to retrieve the creatures. As they collect the creatures, they are attacked by mysterious assassins from a cult that is behind the spreading of the plague.