Departing Pearl Harbor on 22 January 1944, "Zane" subsequently took part in Operation Flintlock, the invasion of the Marshall Islands. As part of the Southern Attack Force, "Zane" was assigned escort duties in the Southern Transport Screen, TU 52.7.1, in company with sistership "Perry", four destroyers, and two subchasers (SC's). She screened transports during the Kwajalein phase of "Flintlock" and subsequently served as "sweep" ship and mine disposal vessel during the invasion and occupation of Eniwetok. In that part of the operation, she suffered minor damage from exploding mines, some of which exploded within 100 yards of the ship.