Pennsylvania Route 65 (PA 65, also known as the 65th Infantry Division Memorial Highway), is a major state highway located in western Pennsylvania, United States. The route, traveling north–south from the Interstate 279/U.S. Route 19 Truck (I-279/US 19 Truck) concurrency in Pittsburgh north to the PA 108/PA 168 concurrency in New Castle, connects downtown Pittsburgh to the northwestern portion of the Pittsburgh Metropolitan Area. PA 65 is similar in its purpose to PA 18 and PA 51, both of which run parallel to PA 65 at one point or another; however, the three routes pass through different cities for most of their respective alignments.