Drawn alongside French Top 14 champions Castres and English sides Exeter Chiefs and Gloucester, Munster competed in pool 2 of the 2018–19 European Rugby Champions Cup. Munster opened their 2018–19 Pro14 season with a six-try 38–0 victory against South African side Cheetahs in Thomond Park on 1 September 2018. Rory Scannell, Dave Kilcoyne, Tommy O'Donnell, JJ Hanrahan, Dave O'Callaghan and Man-of-the-Match Darren Sweetnam scored the tries, with Hanrahan adding four conversions, in a match that saw Arno Botha, Mike Haley, Joey Carbery and academy players Shane Daly and Gavin Coombes make their competitive debuts for the province, whilst Neil Cronin also made his first appearance for Munster since March 2015.