Tamayo, along with Soviet cosmonaut Yuri Romanenko, was launched into space aboard Soyuz 38 from Baikonur Cosmodrome on September 18, 1980, at 19:11 UTC. After docking with Salyut 6, Tamayo and Romanenko conducted experiments in an attempt to find what caused space adaptation syndrome (SAS), and perhaps even find a cure, and on the crystallisation of sucrose in microgravity, for the benefit of Cuba's sugar industry. The SAS experiment involved wearing special adjustable shoes that placed a load on the arch of the foot for six hours a day. After 124 orbits of the Earth (lasting 7 days, 20 hours and 43 minutes), Tamayo and Romanenko landed from Dzhezkazgan. The landing was risky, as it was at night.