Retired from public life as of December 1847, he died of pneumonia in his Mexico City house on 20 February 1850 at age 56. He was buried at the Convent of San Diego in central Mexico City (today, Ex-Convento de San Diego). His granddaughter Josefa Canalizo Valdez, daughter of his son Antonio Canalizo Danila and Procopia Valdez Osuna, married Don Guillermo Haas de la Vega, a legendary half-German entrepreneur from Mazatlán city and grandson of Sinaloa state governor Rafael de la Vega y Rábago of the De la Vega family dynasty of state governors.