Following his recovery, Snow left for a second mission to Illinois and Kentucky in the fall of 1838. He served there through February 1839, when he learned that the Latter Day Saints had been expelled from their settlements in Missouri. He traveled home by way of his former mission area in Ohio. He was again taken ill and was cared for by church members. He remained in Ohio, preaching and working with church members until the fall of 1839. During the school year of 1839–40, Snow taught in Shalersville, Ohio. He sent money to his family, which had by then settled in Nauvoo, Illinois; he joined them in May 1840.