The Clayton High School Clippers compete as one of the member schools in the Tri-County Conference, which is comprised of public and private high schools located in Camden, Cape May, Cumberland, Gloucester and Salem counties. The conference is overseen by the New Jersey State Interscholastic Athletic Association (NJSIAA). With 304 students in grades 10-12, the school was classified by the NJSIAA for the 2019–20 school year as Group I for most athletic competition purposes, which included schools with an enrollment of 75 to 476 students in that grade range. The football team competes in the United Division of the 95-team West Jersey Football League superconference and was classified by the NJSIAA as Group I South for football for 2018–2020.