) results in oxidation of the alcohol to a carboxylic acid. This classical protocol, involving a "direct addition", is used very often regardless of the fact that it frequently leads to the formation of substantial amounts of esters (possessing the structure R-CO-O-CH2-R) derived from oxidative dimerization of primary alcohols. Holland and Gilman proved that this side reaction can be greatly suppressed by following the "inverse addition" protocol whereby a solution of the primary alcohol in acetone is slowly added to Jones reagent under conditions as dilute as practical.