The show follows a robot named Robot Jones who attends the fictional suburban Polyneux Middle School in a retrofuturistic 1980s world. In each episode, Robot Jones researches an aspect of human life, which include music, facial hair, gym class, etc. He is guided by his three friends, who go by the nicknames Socks, Mitch, and Cubey. Robot Jones is often smitten with his crush, Shannon Westerburg, a tall, young girl with orthodontic headgear and a prosthesis. In school, Robot Jones interacts with his teachers, Mr. McMcMc, Mr. Workout, and Mrs. Raincoat; the principal, Mr. Madman; and janitor Clancy Q. Sleepyjeans. His arch-rivals, Lenny and Denny Yogman, try to sabotage Jones's research by making school more difficult for him.