Squyres has participated in many of NASA's planetary exploration missions. From 1978 to 1981 he was an associate of the Voyager mission to Jupiter and Saturn, participating in analysis of imaging data. He subsequently worked as a radar investigator on the Magellan mission to Venus, and with the Near Earth Asteroid Rendezvous mission. Along with his work as principal investigator on the MER (Mars Exploration Rovers), he is also a co-investigator on the 2003 Mars Express and 2005 Mars Reconnaissance Orbiter missions, a member of the Gamma-Ray Spectrometer Flight Investigation Team for the Mars Odyssey mission, and a member of the imaging team for the Cassini to Saturn. Squyres served as Chair of the NASA Space Science Advisory Committee and as a member of the NASA Advisory Council (NAC). In November 2011, NASA Administrator Charles Bolden named Squyres chairman of the NAC, succeeding Kenneth Ford, the founder and director of the Florida Institute for Human and Machine Cognition.