Sir William de la Pole was the town's first mayor. A prosperous merchant, de la Pole founded a family that became prominent in government. Another successful son of a Hull trading family was bishop John Alcock, who founded Jesus College, Cambridge and was a patron of the grammar school in Hull. The increase in trade after the discovery of the Americas and the town's maritime connections are thought to have played a part in the introduction of a virulent strain of syphilis through Hull and on into Europe from the New World.