In 2018, the Nor'easters had to play all of their games on the road, starting with a 3-0 win in Ypsilanti, Mich. over NPSL power AFC Ann Arbor. Next, they traveled to North Carolina to take on the Charlotte Independence of the USL and they won the game 3-1 to earn their sixth win over a professional team in the competition. It was the first time they had upset a professional team away from home and it was the first time they did so while allowing a goal (the previous five were all shutouts). They would return to North Carolina where their US Open Cup run would come to an end with a 4-1 loss to North Carolina FC of the USL.