On September 13, 2020, Kingsbury led the Cardinals to win their first game of the 2020 NFL season by defeating the defending NFC champions San Francisco 49ers by a score of 24–20, marking Kingsbury's first win of the season. It marked the first time the Cardinals won a Week 1 game since 2015. It also marked Kingsbury's 6th win of his NFL head coaching career. On October 25, 2020, Kingsbury’s Cardinals defeated the undefeated Seattle Seahawks by a score of 37–34 in overtime to improve to 5–2 on the season.