Murdock joined the faculty of Yale University in 1928. His PhD from the institution was in the field of Sociology, as Yale at that time did not yet have a Department of Anthropology. Murdock taught courses in physical anthropology. In 1931, Yale established an anthropology department and hired Edward Sapir as the chairman. Murdock's sociological and positivist approach to anthropology was at odds with Sapir's Boasian approach to cultural anthropology. Following Sapir's death, Murdock served as chairman of the Department of Anthropology from 1938 until 1960, when he reached the then mandatory retirement age at Yale. However, he was offered the chair of Andrew Mellon Professor of Social Anthropology at the University of Pittsburgh. Leaving his long-time residence at 960 Ridge Road in Hamden, Connecticut, Murdock moved with his wife to 4150 Bigelow Boulevard in Pittsburgh. He taught at the University of Pittsburgh until his retirement in 1973, at which point he moved to the Philadelphia area to be close to his son.