In "The New Guardians", Extraño helped his team defeat a number of supervillains while trying his best to assist teammates with their personal problems. On one mission in particular, he was attacked by an "AIDS vampire" called the Hemo-Goblin. He was subsequently confirmed to be HIV-positive but it is unclear whether he was infected by Hemo-Goblin or had already been infected prior to his introduction. Though he showed no outward signs of the disease, his infection remained a somewhat unorthodox plot point. Although the Guardians continued to fight evildoers behind the scenes even after their comic ended, their island base was attacked and swallowed up by the villain Entropy in the pages of "Green Lantern". For a time it was assumed Extraño died during this incident, but the subsequent reappearance of other New Guardians throws this into doubt.