In 2010, he won his second World Poker Tour title by winning the WPT Doyle Brunson Five Diamond World for over $870,000. On July 3, 2012, he won the largest buy-in tournament in history, the Big One for One Drop, a $1,000,000 buy-in live event. After beating 47 other players, he earned $18,346,673, the biggest cash prize in poker history. The same year at the 2012 World Series of Poker Europe, Esfandiari won his third bracelet in the €1,100 No Limit Hold'em event, defeating Remi Bollengier heads-up to earn €126,207. In the 2013 World Series of Poker, he placed fourth in the One Drop High Roller tournament, the successor to the Big One that he had won a year earlier, and earned $1,433,438.