"A Fight to the Finish" begins with a snatch of Cole Porter's song "And The Villain Still Pursued Her", which had also been used as the theme for the Fanny Zilch cartoons. The narrator opens with an urgent recap of the (nonexistent) previous episode: "In our last episode, we left Mighty Mouse at the old Beaver River station. As you remember, folks, he was locked in a desperate struggle with a villain. But on with the story..." Mighty Mouse is engaging in "a fight to the finish" with Oil Can Harry, now a villainous cat with a mustache, a top hat and a big black cloak, voiced by Tom Morrison. The blonde heroine, Pearl Pureheart, is tied up in the other room, but refuses to give up hope. Harry manages to knock out Mighty Mouse, and leaves him tied to the railroad track with a bomb on his head, and the 5:15 train due to pass by. Harry drives Pearl away to his home, where he woos her in song, to no avail. Mighty Mouse manages to blow out the fuse, stop the train and escape from his bonds, and rushes to Pearl's rescue. At Harry's house, they fight with fists, guns and swords, as Pearl slips out the window and onto a passing log which is floating down the river into a mill. Mighty Mouse throws Harry into the river and rushes to rescue Pearl, who's heading for the buzzsaw. The narrator asks, "Is our little heroine doomed to destruction in the sawmill? Will Mighty Mouse arrive in time? See the following episode, next week!" The camera starts to iris out, but then stops, as the narrator relents, "Stop! Gosh, we can't wait until next week. Please, show us what happens, won't you?" Mighty Mouse grabs Pearl in time, and the pair have a brief romantic chorus together as the cartoon delivers a happy ending.