The turnpike's southern terminus lies at the approach to the Delaware Memorial Bridge in Carneys Point and Pennsville townships, with a series of closely-spaced interchanges that provide access to Route 49, US 130, northbound I-295, eastbound US 40, Route 140 and County Route 540 (CR 540) along with several local roads. Through this section, the turnpike has three northbound lanes and two southbound lanes. The Route 49 and US 130 exits are labeled 1A and 1B respectively, while the other exits are unnumbered. The turnpike loses its third northbound lane, and continues on with two lanes in each direction and a speed limit. After crossing over Game Creek, the turnpike reaches the Exit 1 Toll Plaza, where northbound drivers must obtain a ticket, and southbound drivers must surrender their ticket and pay the proper toll. Two Express E-ZPass lanes are provided in each direction. Paralleling I-295, the turnpike continues north/northeast through rural Salem County with two lanes in each direction. After passing under Route 48, the turnpike enters Oldmans Township, where it has the John Fenwick Service Area northbound and the Clara Barton Service Area southbound. The turnpike then briefly enters Pilesgrove Township before crossing the Oldmans Creek into Woolwich Township, Gloucester County.