During their investigation, Jonathan receives information from Karen (Kikuko Inoue), Lorraine's daughter with Hojo, that Hojo was growing increasingly stressed working at Tokugawa Pharmaceuticals, which is helping research medical solutions to health problems caused by living in space. Jonathan and Ed also run into former Policenauts Gates Becker (Osamu Saka) and Joseph Tokugawa (Iemasa Kayumi), the latter of whom Jonathan suspects of being involved. They get further leads from an informant, Hojo's co-worker who is later killed and used to lure Jonathan and Ed into an unsuccessful booby trap. Hojo's body is eventually found, and Jonathan is framed for the killings. Tokugawa and Becker are revealed to have both been responsible for Jonathan's accident, and the prime movers behind an illegal drug and organ trafficking ring designed to counteract the negative side-effects of being in space for long periods of time.