Amalie Dietrich was born in Siebenlehn, Saxony, German Confederation. In 1846, she married Wilhelm August Salomo Dietrich, a doctor. With no formal training she learnt all she could from him about collecting and they planned careers working as naturalists. Between 1845 and 1862 they made a precarious living collecting Alpine specimens to sell to chemists for medicines and to museums for their natural history collections. Some of the delicate alpine flowers she collected in this period can be seen on display in the Natural History Museum in Freiburg.