Brondello started her WNBA career in 1998 by being selected in the fourth round (34th overall) by the newly formed Detroit Shock, becoming an All-Star in the first WNBA All-Star Game in 1999. She was selected by the Indiana Fever in late 1999's expansion draft, but never played a game for them, being traded to the Miami Sol along with a first-round pick for Stephanie McCarty. After sitting out of the 2002 season due to a foot injury playing for Wuppertal during the WNBA offseason, Brondello signed as a free agent with the Seattle Storm in 2003, joining fellow Australians Lauren Jackson and Tully Bevilaqua. Brondello was one of the top three-point shooters in league history, her .410 percentage ranking fourth all-time.