KTVO had been serving the Quincy–Hannibal–Keokuk, Iowa market as the default analog ABC affiliate on cable with some locations being able pick up its over-the-air signal. On August 28, 2007, sister station KHQA (which had served as CBS' affiliate of record in the Kirksville market after 1974) announced that they would launch a new second digital subchannel to offer ABC programming beginning September 30. However, KTVO remains on area cable systems, and launched a CBS-affiliated second digital subchannel on May 15, 2010 effectively marking the network's return to the area after a 36-year absence. Like KHQA-DT2, KTVO-DT2 originally offered America One as a secondary affiliate but has since added syndicated programming to its schedule. On February 28, 2013, Barrington Broadcasting announced the sale of its entire group, including KTVO, to Sinclair Broadcast Group. The sale was completed on November 25. In November 2015, KTVO celebrated the 60th anniversary of its original airdate.