Barry was known as the class cartoonist in her grade school. While studying fine arts at The Evergreen State College, she began drawing comic strips compulsively when her boyfriend left her for another girl: "I couldn't sleep after that, and I started making comic strips about men and women. The men were cactuses and the women were women, and the cactuses were trying to convince the women to go to bed with them, and the women were constantly thinking it over but finally deciding it wouldn't be a good idea." These were the cartoons Groening and Keister published as "Ernie Pook's Comeek". Barry also credits her start in comics to Evergreen State professor Marilyn Frasca, saying, "The lessons I learned from her when I was 19 and 20, I still use every day and have never been able to wear out."