The 4751st Air Defense Wing (Missile) was organized at Hurlburt on October 1, 1957. It was redesignated the 4751st Air Defense Missile Wing on January 15, 1958 and discontinued on July 1, 1962 when Tactical Air Command took over the field. Its subordinate 4751st Air Defense Missile Squadron continued operations as a tenant until November 30, 1979. It operated IM-99/CIM-10 Bomarc surface-to-air missiles from this site. On August 18, 1960, a Bomarc missile from the Santa Rosa launch facility made a direct hit on its target, a QB-47E drone of the 3205th Drone Group, marking the first shoot-down of a multi-jet medium bomber by a surface-to-air missile.