Posey made her film debut in "Joey Breaker" (1993). Following small roles in "Coneheads" and the cult classic "Dazed and Confused" (also 1993), she was labeled "Queen of the Indies" for starring in a succession of independent films throughout the 1990s, such as "Sleep with Me" (1994), "Frisk", "Party Girl", "The Doom Generation", "Kicking and Screaming" (all 1995), "The Daytrippers" (1996), "Henry Fool", "The House of Yes" and "Clockwatchers" (all 1997). Her other notable film appearances include "You've Got Mail" (1998), "Scream 3" (2000), "Josie and the Pussycats" (2001), ', "The Sweetest Thing" (both 2002), ' (2004), "Superman Returns", "Fay Grim" (both 2006), "Broken English" (2007), "The Eye" (2008), "Spring Breakdown" (2009)," Inside Out" (2011), "Irrational Man" (2015), "Café Society" (2016) and "Columbus" (2017).