Zakrzewska traveled to Boston as her desire for a greater challenge grew. She fell in love with the city and was offered an appointment as Professor of Obstetrics and Diseases of Women and Children as well as to serve as head of a new clinical program at the Boston Female Medical College. Zakrzewska found that the people of Boston were more supportive of a female physician than those whom she encountered in New York. When the founder of the college, Samuel Gregory, insisted that graduating female physicians would be addressed as "doctresses" instead of doctor, Zakrzewska resigned from her position in 1861.