She then took up regular cruising station on the lower Mississippi River, protecting transports, landing reconnaissance parties, and keeping the river free from Confederate guerrillas. While on this duty, she engaged a Confederate battery off Tunic Bend, Louisiana, on 19 May forced it to withdraw, and landed a shore party which burned the Confederate headquarters. "General Price" continued her patrol duties between New Orleans, Louisiana and Donaldsonville, Louisiana, until the end of the war. She decommissioned at Mound City, Illinois, on 24 July 1865 and was sold on 3 October 1866 to W. H. Harrison.