After the capsule crashes on an unknown planet, Druuna awakens alone. She is soon caught in a war between two alien species, one of which is composed of parasitic beings who need organic specimens as hosts, and the other of intelligent robots pursuing the objective of creating organic life. Apparently, the planet is Earth thousands of years after a war between men and machines resulted in the extinction of the former. The machines want to recreate their creators to try to understand humanity. Will briefly reappears and is kidnapped. Shastar also reappears, now working with the machines in their aim to recover the human species. Toward that aim, they decide to clone Druuna.