Skirting the western edge of the town, the route intersects MD 363 (Deal Island Road/Manokin Avenue) before crossing the Manokin River. Continuing north, the route soon crosses MD 362, with a park and ride lot on the southwest corner of the intersection, and passes by some businesses past that intersection. The next intersection is with the western terminus of MD 822 (UMES Boulevard), which heads east to provide access to the University of Maryland Eastern Shore campus. US 13 curves northeast and exits the town, intersecting the northern terminus of MD 675 in the town's outskirts. It continues through wooded areas, again closely paralleling the Delmarva Central Railroad. US 13 reaches a junction with the northern terminus of MD 529, a rural route that heads south back to Princess Anne on Loretto Road. Past MD 529, the road continues northeast, intersecting Peggy Neck Road. From here, the highway heads through more woodland before passing through the community of Eden and continuing into open farmland.