Griffin faced former PRIDE Lightweight Champion, Takanori Gomi on August 1, 2010 at , replacing an injured Joe Stevenson. Griffin lost via KO (punch) at 1:04 of the first round. This marked the first time Griffin had lost back to back fights, as well as the first time he had been stopped in a fight as all of his previous losses had gone to a decision. Griffin was visibly upset with the loss; pacing around the octagon and refusing to shake Gomi's hand.