The most important of these missionaries was Ippolito Desideri, an Italian Jesuit who left Rome in 1712 with the blessing of Pope Clement XI and arrived in Lhasa on 18 March 1716. Desideri's various journeys between 1716 and 1721, when he was withdrawn by Rome, encompassed a circuit of the Tibetan borders with Nepal, modern Kashmir and Pakistan. The Capuchins became the sole Christian missionaries in Tibet for the next twenty-five years. The Capuchins met increased opposition from Tibetan lamas before finally being expelled from Tibet in 1745.