Coming off their wild card home win over the Titans, the Chargers flew to the RCA Dome for their AFC Divisional duel with the second-seeded/defending Super Bowl champion Indianapolis Colts, in a rematch of Week 10. In the first scoring play, Peyton Manning threw a TD to Dallas Clark for 25 yards. LaDainian Tomlinson was injured on a running play and despite an attempt to return to action later in the first half, he did not return to the game. Philip Rivers then threw a pass to Vincent Jackson for San Diego's first TD of the game. Adam Vinatieri made a 46-yard FG to put the Colts up 10–7. Antonio Cromartie intercepted Peyton Manning at the end of the first half and ran it 89 yards for a touchdown; however, the play was called back on a dubious holding call by Phil Luckett. The second half began with Rivers tossing a pass to Chris Chambers for 30 yards. At 3:19 of the third quarter, Manning completed a pass for Reggie Wayne for 9 yards. Rivers managed to complete a 56-yard pass to Darren Sproles for a touchdown. On that play, Rivers injured his leg and did not return to the game. Billy Volek replaced Rivers at quarterback. Starting the fourth quarter, Manning threw a TD pass to Anthony Gonzalez for 55 yards. Volek engineered a long drive culminating in a 1-yard sneak for a TD putting the Chargers up for good.