Isidro started as a back-up singer together with her sisters Olive Cruz and Tina Isorena in "The Sharon Cuneta Show". She was urged by Johnny Manahan or Mr. M to fill in for then pregnant Melissa de Leon in the noon time show '"Sang Linggo nAPO Sila". She was like a breath of fresh air and people started noticing her, hence, the moniker "Crush ng Bayan" or "the people's crush" and also as the "Julia Roberts of the Philippines". She is best known for her role as Ingrid Martinez, the main villainess in the 2009 hit television series, "Tayong Dalawa". She then played kind-hearted roles.