On July 7, 2007 he was promoted to the Major League ball club, starting in place of the disabled John Smoltz against David Wells and the San Diego Padres. His first earned run came in the second inning on a solo home run by Khalil Greene. In his first plate appearance the following inning, he laid down a successful sacrifice bunt to move Jarrod Saltalamacchia to third base. Reyes lasted only 3+ innings however, giving up five earned runs on five hits and three walks while striking out one. He received no decision in the game. Reyes earned his first Major League win on September 18, 2007 in a 4-3 Braves' win against the Florida Marlins at Turner Field.