In the Mideast Regional, the top four seeds all advanced to the regional semifinal, then both higher seeds were upset. 4th seed Xavier knocked off the number one seed in the regional, Tennessee, by a score of 80–65. Third seeded Purdue played second seeded Texas Tech in a game that came down to the wire. Purdue won 74–72, then went on to defeat Xavier for the spot in the Final Four against Missouri State. The upset run by Missouri State came to an end in the semifinal, as Purdue beat them 71–64. The career of Jackie Stiles, who had scored 1,064 points during the season, the only player in NCAA Division I women's basketball history to score 1000 points in a season, came to an end.