PA 340 enters Leacock Township and runs through open agricultural land with occasional residences. The road heads into the community of Intercourse and passes homes and businesses. PA 340 intersects PA 772 and forms a concurrency with that route on Main Street, with the road gaining a center left-turn lane. PA 772 splits to the southeast and PA 340 passes more residential development on Old Philadelphia Pike. The road leaves Intercourse and loses the turn lane, continuing through more farmland. The route heads into Salisbury Township and runs through more rural areas, passing through the community of Spring Garden. PA 340 comes to an intersection with PA 897 and runs concurrent with that route before PA 897 turns south in the community of White Horse. Following this, the road runs east through more areas of farm fields, crossing Pequea Creek and passing through the community of Cains.