In 1990-1991, she starred as the devious Catherine Martell in David Lynch's television series "Twin Peaks". She also appeared in "Other People's Money" with Gregory Peck (1991), and in horror maestro Dario Argento's first American film "Trauma" (1993). She played George Clooney's character's mother on "ER". In 1997, she appeared in the film "A Christmas Memory" with Patty Duke, and in 1998, she appeared in the sci-fi thriller "The Faculty". She made guest appearances on television shows such as "Frasier", "Matlock", "State of Grace", and "Will & Grace". Laurie also appeared in "Cold Case" and in a 2001 episode of "" titled "Care", in which she played an adoptive mother and foster grandmother who killed one of the foster granddaughters in her daughter's charge and who abused her adoptive son and foster grandchildren.