As soon as the college baseball season had ended, Vick signed with the St. Louis Cardinals and joined the team in Boston on June 5, 1922. He made his Major League debut on June 29, 1922, but spent most of the 1922 season playing for the Cardinals' affiliate in the American Association at Syracuse. Vick batted .320 with Syracuse in 1922. In the spring of 1923, Vick played with the Houston Buffs, and did not play in any Major League games during the 1923 season. In 1924, Vick appeared in 16 games for the Cardinals and compiled a .348 batting average and .423 on-base percentage. After the 1925 season, columnist Billy Evans wrote that Vick was an "excellent baseball prospect," but injuries had "kept him from proving his real worth as a big leaguer." His most serious injury was "a badly shattered thumb" that threatened to end his career.