On 13 May 1944, "San Pablo" and "Tangier" moved to Hollandia, New Guinea, to patrol the approaches to Wakde Island prior to Allied landings there. Relieved by seaplane tender on 26 May 1944, "San Pablo" then refueled PT boats at Humboldt Bay, New Guinea, and transported personnel and cargo between Manus Island, Seeadler Harbor, Emirau, and Mios Woendi. On 19 August 1944, she commenced antisubmarine patrols with Patrol Squadron 11 (VP-11) planes at Mios Woendi and, during October and November 1944, conducted antisubmarine operations off Morotai and Hollandia.