In 2006, Toope became the 12th president and vice-chancellor of the University of British Columbia succeeding Martha Piper. He also held an academic position at the university as a tenured professor of law. He assumed the presidential post on July 1, 2006, and held the position for eight years, until June 30, 2014. On April 3, 2013, it was announced that Toope would leave the UBC presidency effective June 2014 to "pursue academic and professional interests in international law and international relations".