The university grew out of the Colegio de Santo Tomás de Aquino (Saint Thomas Aquinas High School), founded in 1562 by Bishop Francisco Marroquín. After a series of major earthquakes in 1773, which destroyed many parts of the city of Santiago de los Caballeros, the crown authorities ordered the evacuation of the city and the relocation of its government, religious and university functions to the new capital La Nueva Guatemala de la Asunción, the university's present location. In the early years, from the 16th to 19th centuries, it offered studies in civil and liturgical law, theology, philosophy, medicine and indigenous languages.