Generally, GLUT-1 acts as a facilitative transporter of glucose, transporter glucose along its concentration gradient. When glucose binds to GLUT-1, it stimulates a conformational change, allowing glucose to be released on the opposite side of the membrane (4,12). GLUT-1 is a bidirectional transporter and possesses glucose binding sites accessible on both the cytoplasmic and extracellular faces (4,12). On the rare occasion that GLUT-1 transports glucose against its concentration gradient, Glut-1 uses an energy source, typically ATP, to move the glucose. Like GalP, GLUT-1 is inhibited via the binding of cytochalasin B and forskolin (12).