For its first in southern Hamilton, the route is White Horse-Mercerville Road, as it connects the two census-designated places of White Horse and Mercerville. Along the way, it accesses both Interstates 295 (exit 61) and 195 (exit 2) via Arena Drive, just from the southern terminus. In Mercerville, it intersects Route 33, providing access to downtown Trenton and the business-laden stretch of Hamilton Square. Less than later, CR 533 meets CR 535 and Nottingham Way at a five-point intersection, and continues north as Quaker Bridge Road.