Upon crossing the Pocomoke River, US 13 heads into Somerset County and intersects the northern terminus of US 13 Bus. and the southern terminus of MD 364 (Dividing Creek Road). From here, the route comes to a bridge over the Delmarva Central Railroad's Delmarva Subdivision line and curves to the northwest, running through rural countryside. It features an intersection with the eastern terminus of MD 667 (Rehobeth Road), and the route continues from farmland into heavy woodland. US 13 heads back into agricultural areas where it intersects many unsigned suffixed segments of MD 920 which are mostly short, dead-end roads. The route continues west and northwest before the median widens and it intersects the eastern terminus of MD 673 (Sam Barnes Road), which provides a connection to southbound MD 413 and Crisfield. A park and ride lot is located north of this intersection. Past MD 673, the median narrows and US 13 turns north to meet the northern terminus of MD 413 (Crisfield Highway), with access to that route only in the southbound direction.