In the 1990s, she was one of the first scientists pointing out the importance of the mast cell in human pathology. In the same period (1993), she identified the endogenous compound palmitoylethanolamide as an important modulator of this cell. Understanding this mechanism initiated a new era of research into this compound which has resulted in more discoveries regarding its mechanisms and benefits, a far better understanding of the endocannabinoid system and new liposomal palmitoylethanolamide product formulations designed specifically for improved absorption and bioavailability.