Hamilton Square station was built by the Mersey Railway and opened on 1 February 1886. The station building was designed by G. E. Grayson in Italianate style, and has been designated as a Grade II listed building. It stood on that railway's original route from James Street station in Liverpool to Green Lane, later extended to Rock Ferry and Birkenhead Park. Just south of the station, the lines towards Rock Ferry and Birkenhead Park diverge; this junction was originally built as a flat crossing.