What would become PA 63 was originally designated as Legislative Route 198 in 1911, running from Green Lane to Northeast Philadelphia. When first designated, PA 63 ran from PA 29 in Green Lane to US 611 (now PA 611) in Willow Grove, following its current alignment. In 1928, it was extended east to PA 532 in Northeast Philadelphia, following Edge Hill Road, Terwood Road, and Welsh Road to Bethayres, where the route continued along Philmont Avenue to PA 532. By 1940, PA 63 was moved to its current alignment between Willow Grove and Bethayres and was realigned to follow Byberry Road to PA 532. The former alignment of PA 63 on Edge Hill Road and Terwood Road became PA 163, which was removed by 1950. In the 1950s, the Woodhaven Road freeway was planned to serve Northeast Philadelphia, connecting I-95 to PA 63 at Philmont Avenue, with a further extension to I-276 (Pennsylvania Turnpike) in Southampton once planned. The freeway was completed to Evans Street just west of US 1 in the 1960s and PA 63 was extended along Byberry Road and Woodhaven Road to end at I-95. In the 1980s, PA 63 was rerouted to use Red Lion Road and US 1 to reach Woodhaven Road. Plans to extend Woodhaven Road through the rest of Northeast Philadelphia remain, but have been on hold due to community opposition and financial constraints.