A three-time Pro Bowl selection during his seven seasons with the Vikings, Culpepper's most successful season came in 2004 in which he set a then-single season record for the most total yardage produced by an NFL quarterback at 5,123. However, Culpepper suffered a serious knee injury the following season that ended his Vikings career. After his injury, he played sparingly in the NFL for the Miami Dolphins, Oakland Raiders, and Detroit Lions. His professional career concluded after one season with the Sacramento Mountain Lions of the United Football League (UFL).