Lott ran for the Senate in 1988, after 42-year incumbent John Stennis announced he would not run for another term. He defeated Democratic 4th District Congressman Wayne Dowdy by almost eight points. Lott won by running up a 70 percent margin in his congressional district, and was also helped by George H. W. Bush easily carrying the state in the presidential election. He never faced another contest nearly that close. He was re-elected in 1994, 2000, and 2006 with no substantive Democratic opposition. He gave some thought to retirement for much of 2005, however, after Hurricane Katrina, he announced on January 17, 2006 that he would run for a fourth term.