Quinn signed a five-year deal with the Browns worth a reported $20.2 million, with $7.5 million guaranteed and up to $30 million in incentives. Quinn was originally placed third on the Browns' depth chart behind Charlie Frye and Derek Anderson. However, after a 34–7 defeat to the Pittsburgh Steelers in Week 1, Frye was traded to the Seattle Seahawks for a sixth round draft pick, moving Quinn to second on the Browns' depth chart. On December 30, 2007, when Anderson hurt his pinky and wrist, Quinn made his official NFL debut in the Browns' final game of the season against the San Francisco 49ers. Going 3 for 8 passing, Quinn led the Browns to a field goal. Despite speculation that the Browns would trade Anderson to get back into the first round of the 2008 NFL Draft, Browns' general manager Phil Savage later stated that he hoped to sign Anderson, and keep both quarterbacks for the 2008 season.