It is said that the MacIntyre chief at the time of the Jacobite rising of 1745, James (born c. 1727), would have joined the clans rallying to Prince Charles Edward Stuart but was dissuaded from doing so by his wife, who was a Campbell, and his neighbors. His loyalties to the Campbells were further deepened by the fact that his legal studies had been sponsored by the Campbell Earl of Breadalbane. Nonetheless, many MacIntyres were in the clan regiment of Stewart of Appin in the campaign of 1745–46, but they did not serve as an independent body.