The largest change came in terms of trade and technology. The global significance of the fall of the Byzantines was the disruption of overland routes between Asia and Europe. Traditional dominance of Nomadism in Eurasia declined and the Pax Mongolia which had allowed for interactions between different civilizations was no longer available. China, which had previously engaged in expansion and innovation became isolationist in the 14th century under the Ming and would remain so until the Industrial Revolution. Western Asia and South Asia were conquered by gunpowder empires which successfully utilized advances in military technology but closed the Silk Road.