One of her major works was a contribution to the book "The Gender and Science Reader". Keller's article, entitled "Secrets of God, Nature, and Life" links issues in feminism back to the Scientific Revolution in the 17th Century and the Industrial Revolution in the 18th Century. In this work, she quotes Boyle. "It may seem an ingrateful and unfilial thing to dispute against nature, that is taken by mankind for the common parent of us all. But although it be as undutiful thing, to express a want of respect for an acknowledged parent, yet I know not, why it may not be allowable to question one, that a man looks upon but as a pretend one; and it appear to me, that she is so, I think it my duty to pay my gratitude, not to I know not what, but to that deity, whose wisdom and goodness...designed to make me a man." (pg. 103) By Keller addressing Boyle's quote in this aspect, she alludes to how as soon as questionable aspects are displayed in nature, "nature" becomes "nature" and is then feminine.