In 2012, she transferred to GMA Network and signed an exclusive contract in Kapuso Network, her first major project was the television series of GMA Network entitled, "One True Love" where in she played Leila Samonte, the bitter and scheming doctor who made Elize and Tisoy lives miserable. She later returned to her original home network, ABS-CBN, as a freelancer in 2013 through a comeback project via "Muling Buksan ang Puso", starring Julia Montes, Enrique Gil and Enchong Dee while also being seen in GMA-7's Titser. Isidro played a supporting role as Marian Rivera's mother in Carmela on GMA Network but immediately started doing projects with ABS-CBN after the show ended.