After many hard-fought years practicing medicine and establishing accessible medical education for women, Zakrzewska retired in 1890. She spent the rest of her life consulting on projects and arranging affairs. In 1899, the main building of the hospital would be renamed the "Zakrzewska Building." Marie Zakrzewska died a few years later on May 12, 1902 in Jamaica Plain, Massachusetts due to what was thought to be a heart attack. During her service, her fellow colleagues and friends gathered to pay their respects, reading farewell letters that Zakrzewska had written for the occasion. Her home is a site on the Boston Women's Heritage Trail and