For most of the series, the Larry David character is living a married, child-free life in Los Angeles with his wife Cheryl (Cheryl Hines). David's main confidant on the show is his manager and friend Jeff Greene (Jeff Garlin). Susie Essman plays Susie Greene, Jeff's short-tempered wife, who is frequently at odds with Larry. Many of the show's frequent guest stars are celebrities and public figures, who will usually play fictionalized versions of themselves. Among the more frequently recurring guest stars are Larry's longtime friend Richard Lewis as well as Ted Danson and his wife Mary Steenburgen.