Amo returned to the University of Halle to lecture in philosophy under his preferred name of Antonius Guilelmus Amo Afer. In 1736 he was made a professor. From his lectures, he produced his second major work in 1738, "Treatise on the Art of Philosophising Soberly and Accurately", in which he developed an empiricist epistemology very close to but distinct from that of philosophers such as John Locke and David Hume. In it he also examined and criticised faults such as intellectual dishonesty, dogmatism, and prejudice.