Born in Craiova, into a family of intellectuals, he attended the Carol I High School in the city. In the art classes he was guided by teacher Eugen Ciolac, who taught him some of the techniques he was to use. His participation was first noted during the exhibition organized in 1925 in the reception hall of the Dolj County Administrative Palace. Although his artistic talent was becoming appreciated, Ţuculescu did not attend a higher-education art school; instead, he went to the Faculty of Natural Sciences within the University of Bucharest, where he would graduate in 1936. In parallel, he also attended the Bucharest Medical University, graduating "magna cum laude" in 1939.