Thermophiles prefer temperatures from , whilst hyperthermophiles grow better at temperatures as high as . As they have heat-stable enzymes that retain their activity even at high temperatures, they have been used as a source of thermostable tools, that are important in medicine and biotechnology, for example in manufacturing antibiotics, plastics, detergents (by the use of heat-stable enzymes lipases, pullulanases and proteases), and fermentation products (for example ethanol is produced). Among these, the first discovered and the most important for biotechnology is "Thermus aquaticus".