After recording 67 rushing yards in a 28-0 loss to the Seattle Seahawks in the season opener, Jackson had 104 rushing yards against the Washington Redskins in a 9-7 loss and 117 rushing yards against the Green Bay Packers in a 36-17 loss. In Week 7, against the Indianapolis Colts, he started a four-game stretch with over 100 rushing yards in each game with a rushing touchdown in the latter three against the Detroit Lions, New Orleans Saints, and the Arizona Cardinals. Overall, he finished the season with 1,416 rushing yards, four rushing touchdowns, 51 receptions, and 322 receiving yards. He was named to his second Pro Bowl.