"Ain't Life Grand" was released on October 20, 2000 through Koch with "Mean Bone" released as the first single. The album did not sell as well as its predecessor, and critical reception to it was mixed. "Entertainment Weekly" reviewer Tony Scherman stated that "Slash's playing is as flashily incendiary as ever, but the songs and arrangements recycle hard-rock cliches worthier of Ratt than of a bona fide guitar god". Rob Sheffield of "Rolling Stone" noted that "great guitarists need great bands, and the Snakepit dudes are barely functional backup peons". Steve Huey of Allmusic noted that "the new Snakepit does kick up a lot of noise as the album rushes by, and the strong chemistry between the members is immediately obvious". However, he stated that songwriting was the main problem, and that "it never rises above the level of solid, and too many tracks are by-the-numbers hard rock at best (and pedestrian at worst)". The band were dropped by Koch two months following the album's release.