After a lengthy search for a team for 2010, that included negotiations with his previous team as well as with and , Simoni re-joined his former Lampre "squadra", rechristened as . The 2010 Giro d'Italia was the final race of his career. He finished 69th overall, 2:40:14 behind two-time winner and compatriot Ivan Basso. Simoni was characteristically frank about his last bid for glory, which poignantly saw him beaten in the sprint for the Cima Coppi KOM prize by the Swiss Johann Tschopp, at the summit of the Passo di Gavia in the penultimate Giro stage. Mobbed at the finish line by Italian media looking for one final quote from a rider who rarely hesitated to speak his mind, Simoni mused: