He was noted especially for ensuring the rescue of 152 women and children when commanding the commercial mail steamer "Central America" in September 1857. During a three-day hurricane off the coast of North Carolina, the ship lost power. Herndon arranged for getting some women and children safely off the ship to another vessel. With no way to save the ship, Herndon chose to stay with more than 400 passengers and crew who drowned as the ship sank off Cape Hatteras on September 12. It was the largest loss of life in a commercial ship disaster in United States history.