After losing his first career game against the Cincinnati Bengals, Reich earned his first win as a head coach over the Washington Redskins. In Week 3 against his former team the Eagles, with the Colts down 20–16 with seconds left in the game, Reich pulled starting quarterback Andrew Luck and put in Jacoby Brissett to attempt a Hail Mary pass from his own 46-yard line. Brissett overthrew several players in the back of the end zone and the Colts lost the game. The move was questioned by some journalists and fans, and led to some speculation about the health of Luck's shoulder, although Reich and Luck both said it was purely because Brissett had a stronger throwing arm. The following week against the Houston Texans, Luck led the Colts back from down 28–10 in the third quarter, including a game-tying two point conversion with :51 left, however the team lost in overtime, 37–34. Reich was the center of controversy after Indianapolis failed to convert a 4th and 4 on their own 43 and the Texans kicked the game-winning field goal, although he afterword said "I'll just address it now. We're not playing to tie. We're going for it 10 times out of 10." After a 1–5 start, Reich led the Colts to a 10–6 record winning nine of their final 10 games.