Wood again served as a late-inning reliever for the White Sox in 1969. On April 13, he had his longest outing of the year, allowing two runs in innings in relief of Gary Peters but earning the win in a 12–7 triumph over the Seattle Pilots. Also against the Pilots in the first game of a June 24 doubleheader, he relieved Dan Osinski with the bases loaded and one out in the sixth inning of a tie ballgame. Wood got Mike Hegan to ground into a force play at home, retired Tommy Harper on a groundout to end the inning, then pitched three more scoreless innings, earning the win in Chicago's 6–4 triumph. In the second game of a July 13 doubleheader, he pitched four scoreless innings for the save in a 4–1 victory over the Kansas City Royals. Wood again led the AL in appearances with 76, ranked second in games finished (50) to Ron Perranoski (52), and finished sixth with 15 saves. He had a 10–11 record, a 3.01 ERA, 73 strikeouts, 40 walks, and 113 hits allowed in innings pitched.