There is almost no specific evidence of Molinos's activities in Rome in 1663–1675. It is known that Molinos was affiliated with the Roman chapter of the School of Christ (and, by 1671 at the latest, had become its leader). He also became well known as a spiritual director – and it was in this role that he gained prominence as the leading advocate of the teaching and practice that would come to be known as Quietism. He was a regular correspondent with Princess Borghese, and counted as an admirer, Cardinal Benedetto Odescalchi, who in 1676 became Pope Innocent XI. He also paid frequent visits to the house of the exiled Christina, Queen of Sweden. He was also in these years working on the case of the Venerable Simón; by 1675, however, Molinos had to admit to his superiors in Valencia that the Congregation of Rites had refused to reconsider the case. Molinos’s royal commission and line of credit were revoked, and he was deprived of his official position in the Valencian delegation in Rome.