Pecos is one of the numerous towns in West Texas organized around a train depot during the construction of the Texas and Pacific Railway. These towns were subsequently linked by the construction of U.S. Highway 80 and Interstate 20. Prior to the arrival of the railroad, a permanent camp existed nearby where cattle drives crossed the Pecos River. With the introduction of irrigation from underground aquifers, the city became a center of commerce for extensive local agricultural production of cotton, onions, and cantaloupes. The introduction of large-scale sulfur mining in adjacent Culberson County during the 1960s led to significant economic and population growth. The growth was reversed after mining operations ceased in the 1990s.