Buses were substituted for streetcars by the New York City Omnibus Corporation (which numbered it 5) on March 3, 1936. When Sixth Avenue between 34th and 59th Streets, Broadway between 34th Street and Columbus Circle, and Seventh Avenue between Times Square and 59th Street became one-way streets on March 10, 1957, the 5's southbound route from 59th to 34th Street was rerouted to Seventh Avenue and then Broadway before rejoining Sixth Avenue. After another set of one-way conversions on June 3, 1962, the southbound 5 in lower Manhattan was rerouted to West Broadway between Lispenard and Vesey Streets. After the rest of Sixth Avenue below 34th Street, and Broadway between 34th and 23rd Streets and between 14th and Canal Streets, were converted to one-way streets on November 10, 1963, the 5 was discontinued and absorbed into the NYCO's bus 6 (which replaced the Broadway Line), which was rerouted largely over the former Sixth Avenue Line northbound.