On May 24, 2018, the band announced a new album set for September 14, 2018 called "Generation Rx". This coincided with the release of a new single called "Actual Pain". They have also announced a tour for 2019 to promote the album. The opioid epidemic inspired the album's title "Generation Rx": Rx is often used as an abbreviation for medical prescriptions in the US. The album initially had the working title "Cold Song", but was changed after the band realised pain was a running theme throughout the album. "Generation Rx" talks about several issues: the opioid epidemic, struggles with mental health, difficulty with self-esteem, and the effect of organized religion on other peoples' lives. According to Joel Madden, the album was "all about that inner struggle, and ... the emotional experience we're all going through that gets us to a place where we want to kill the pain that's in all of us." The band played a surprise guest set on the final Vans Warped Tour on July 29, 2018.