In 2010, Kitna remained idle until October 25, when Romo suffered a broken clavicle against the New York Giants and was later placed on the injured reserve list on December 21. Kitna ended up suffering an abdominal injury against the Arizona Cardinals on December 25, and was replaced with second-year quarterback Stephen Mcgee for the rest of the season. Kitna played well in relief of Romo throwing for 2,365 yards, 16 touchdowns and 12 interceptions in the 9 games he started, compiling a 4-5 record and a career-high 88.9 passer rating in the process.