"One of Us Must Know" is a straightforward account of a burned-out relationship. Dissecting what went wrong, the narrator takes a defensive attitude in a one-sided conversation with his former lover. As he presents his case in the opening verse, it appears he is incapable of acknowledging his part or limiting the abuse: "I didn't mean to treat you so bad. You don't have to take it so personal. I didn't mean to make you so sad. You just happened to be there, that's all." "One of Us Must Know" was the first recording completed for "Blonde on Blonde" and the only one selected from the New York sessions. The song was released as the first single from the album on February 14, the same day Dylan began to record in Nashville. It failed to appear on the American charts, but reached number 33 in the UK.