In the against the Indianapolis Colts, Jackson suffered a torn ACL and was placed on the Patriots' physically unable to perform (PUP) list prior to the 2007 season. He was activated from the PUP on November 7, 2007, but was active for only four of the Patriots' remaining games, finishing the season with one catch for 19 yards. Jackson was active for the Patriots' first playoff game against the Jacksonville Jaguars, but was a healthy inactive for their next two games, the AFC Championship and Super Bowl XLII.