Although "North by Northwest" might have propelled her to the top ranks of stardom, Saint chose to limit her film work in order to spend time with her husband since 1951, director Jeffrey Hayden, and their two children. In the 1960s, Saint continued to distinguish herself in both high-profile and offbeat pictures. She co-starred with Paul Newman in "Exodus" (1960), a historical drama about the founding of the state of Israel adapted from the novel of the same name by Leon Uris. It was directed by Otto Preminger. She also co-starred with Warren Beatty, Karl Malden and Angela Lansbury as a tragic beauty in the drama "All Fall Down" (1962). Based upon a novel by James Leo Herlihy and a screenplay by William Inge, the film was directed by John Frankenheimer.