Tixier-Vignancour entered politics and defeated the independent leftist Georges Moutet in the French legislative election of the department of Basses-Pyrénées in May 1936. His election was however declared non-valid after suspicions of fraud. Tixier-Vignancour was eventually re-elected on 27 September 1936. He was part of a parliamentary group which traveled to Spain to congratulate Francisco Franco on his fight against the Spanish Popular Front. Tixier-Vignancour married Janine Auriol in January 1938, the daughter of a lawyer and member of parliament for Haute-Garonne.