La Salle starred in the Hallmark Channel original movie, "Relative Stranger", which premiered on March 14, 2009. Also in the movie were Cicely Tyson as well as La Salle's former "ER" castmates Michael Michele (Dr. Cleo Finch) and Michael Beach (Al Boulet). In 2010, La Salle played the United Nations Secretary General in the series finale of "24" and guest-starred in an episode of "Covert Affairs" in August of the same year. In 2011, he played two recurring roles: one as a Caribbean community leader who rallied against the product Rasta Monsta in HBO's "How to Make it in America", the second as the neuropsychiatrist E-Mo in CBS' "A Gifted Man".