In March 2013, Tyler was confirmed to be the new host of the American version of "Whose Line Is It Anyway?". She also appears briefly as herself in the video game "Watch Dogs" and is featured in the music video for the "Weird Al" Yankovic song "Tacky". Tyler was also the original voice for the character Daisy Fitzroy in the 2013 video game "BioShock Infinite", but her recordings were not used and the role went to Kimberly Brooks. She was nominated for Personality of 2014 in Golden Joystick Award 2014.