I-75 continues northward through Cheboygan County, passing the community of Indian River and spanning the river of the same name. North of town, the freeway traverses the area between Burt and Mullett lakes before intersecting the southern end of M-27; that highway provides access to Topinabee and Cheboygan. I-75 continues northward through tree farms and other agricultural properties in rural Cheboygan County. Cheboygan is accessible by way of interchanges for C-64 and C-66, a pair of county-designated highways in this area. North of C-66, I-75 turns northwesterly. The freeway meets the northern end of US 31 and picks up the Lake Michigan Circle Tour (LMCT) designation before entering Emmet County on the south side of Mackinaw City. I-75 then parallels the county line on the west side of the village, meeting the northern end of US 23. After that interchange, the Lake Huron Circle Tour (LHCT) merges in from the south. There is one more interchange along the freeway before I-75 ascends the approaches to the Mackinac Bridge.