In 1974, Melzack co-founded the first pain clinic in Canada at the Montreal General Hospital with Dr. Joseph Stratford (then Chief of Neurosurgery at the hospital and who was the medical director of the pain clinic). Melzack served as Research Director from 1974 to 2000. The clinic became part of the McGill University Health Centre which has grown to be one of the best organized centres for pain treatment in the world. Melzack also supervised graduate students at McGill, one of whom —John O'Keefe— would later go on to receive the Nobel Prize in Physiology or Medicine in 2014.