Peelle appeared in 15 games for the Dolphins in 2006, including a career-high ten starts. This was due to the team's increased use of two-tight end sets, which created more time for Peelle and less for fullback Darian Barnes. He finished with 16 catches for 116 yards and one touchdown on the season, marking the fourth consecutive season he had at least one touchdown catch. He was inactive once (on October 15 at the New York Jets) with a knee injury, allowing tight end Jason Rader to make the first start of his career. On November 19 against the Minnesota Vikings, Peelle had three catches for 21 yards and one touchdown, coming on an 11-yard pass from former Oregon teammate Joey Harrington. It was his first touchdown catch as a member of the Dolphins.