"Uh Oh!" was inspired on a game show parody sketch on "It's Alive!" during its second season, where contestants were chained up and answered questions. If a contestant answered incorrectly, a man known as "The Punisher" would pour slime on them from the rafters. In the third season of "It's Alive!", realizing that the game show parody could actually work as a real game show, "Uh Oh!" debuted as part of the slate of game shows during the show's segment. The game was much shorter than its spin-off, with the game consisting of one round of two spins each. Quickly becoming the most popular game show in the segment, the game was played more frequently than its other games. Shortly after "It's Alive!" ended in 1997, "Uh Oh!" later became a show of its own that same year, playing with exactly the same rules as when it was on "It's Alive!", except that there were now two rounds, with an additional round between the two rounds called Slime Tour, which was based on the obstacle course segment from "It's Alive!" involving different teams who were competing against with each other in their own competition.