Reared in Kimball, South Dakota, Ochsner was an unlikely hero of Southern medicine. He was recruited to Tulane from the University of Wisconsin–Madison. In 1927, he succeeded Rudolph Matas as professor and chairman of the Tulane Department of Surgery. Although Tulane did not have its own hospital at the time, Ochsner succeeded in organizing one of America's premier surgical teaching programs at New Orleans Charity Hospital, an institution that provided invaluable clinical opportunities to Ochsner and his students. Ochsner's refusal to hire a friend of Louisiana governor Huey Long formed part of the background for Long's establishing another medical school, now the LSU Health Sciences Center, across the street from the Tulane University School of Medicine.