Simoni failed to defend his title in the 2004 Giro d'Italia with the emergence of his teammate Damiano Cunego. After some public dispute, Simoni reconciled with Cunego and agreed to continue on the same team, which became . In the 2005 Giro d'Italia the team took advantage of the publicity and played up the rivalry between Simoni and Cunego, boasting their strength for the Giro. The early part of the Giro saw Cunego lose significant time in the early mountain stages – he was later diagnosed with Epstein-Barr viral infection – firmly establishing Simoni as the team leader for the Giro. However, Simoni failed to dislodge Paolo Savoldelli in the last mountain stage, even with an epic performance which saw him and Danilo Di Luca work together to gain time on Savoldelli. Suffering from cramps, he also failed to win that stage.