In Week 2, against the Washington Redskins, he had 12 receptions for 158 yards and a touchdown to earn AFC Offensive Player of the Week. On November 28, 2010, against the Tennessee Titans, Johnson became the first player in NFL history to have 60 or more receptions in each of his first eight seasons. In the same game, he fought Tennessee Titans cornerback Cortland Finnegan. After being jammed hard off the line of scrimmage by Finnegan to the head and neck area repeatedly throughout the game, Johnson lost his temper and pulled off Finnegan's helmet. Finnegan then removed and threw Johnson's helmet down-field and was promptly thrown to the ground by his jersey. Johnson then proceeded to strike Finnegan on the back of his head and neck before being pulled away by the referee. Johnson and Finnegan were ejected from the game, but not suspended. Both were fined $25,000 for their unsportsmanlike actions. He was invited to the 2011 Pro Bowl, but the Texans finished 6–10 and missed the playoffs once again. He was ranked No. 7 his fellow players on the NFL Top 100 Players of 2011.