Acquired to back up starting quarterback Jim Ninowski, Ryan moved into the starting slot on October 28 when Ninowski broke his collarbone while being tackled by Pittsburgh Steelers' defensive lineman Eugene "Big Daddy" Lipscomb. With no other candidates to compete with, Ryan established his leadership and held on to the starting role for much of the next six seasons. In his first full season as a starter, 1963, Ryan threw for 2,026 yards and 25 touchdowns with only 13 interceptions, helping the Browns to a 10–4 record. Thirteen of those touchdowns went to Gary Collins, who tied for the league lead in receiving touchdowns that year.