In the early 1970s, she took a temporary hiatus from acting to spend more time with her husband Franco Pesci and their son, Corrado. Nonetheless, Lisi's career underwent a renaissance with a number of projects, including "Al di là del bene e del male" (1977), "Ernesto" (1979), and "La cicala" (1980). For the film "La Reine Margot" (1994), Lisi's portrayal of Catherine de' Medici won her both the "César" and Cannes Film Festival awards, along with a Silver Ribbon for Best Supporting Actress. In 2002, Lisi starred in "Il più bel giorno della mia vita".