Druuna is recruited by Lewis to help him destroy Delta. Unaware of fact that it would mean destruction of the City and all its inhabitants, Druuna finds Delta and carries out Lewis's plan. At the end Lewis reveals his true plan to destroy the City, but also confesses he fell in love with her and changes his mind about destruction. In turn, Lewis puts Druuna in a state similar to hibernation for centuries, waiting for an opportunity to improve conditions on the City. The story then introduces a man named Will, who commands another ship, similar to the City, which has become, thanks to the evolution of Evil, a super-organism. It is revealed that apart from the City, humanity is not entirely extinguished, but that other groups of humans survived, using genetic engineering to improve their abilities.