The Portuguese Inquisition formally started in Portugal in 1536 at the request of King João III. Manuel I had asked Pope Leo X for the installation of the Inquisition in 1515, but only after his death in 1521 did Pope Paul III acquiesce. At its head stood a "Grande Inquisidor", or General Inquisitor, named by the Pope but selected by the Crown, and always from within the royal family. The Portuguese Inquisition principally focused upon the Sephardi Jews, whom the state forced to convert to Christianity. Spain had expelled its Sephardi population in 1492; many of these Spanish Jews left Spain for Portugal but eventually were subject to inquisition there as well.