SR 25 crosses into the city of Westbrook, where it uses Wayside Drive and the Westbrook Arterial to bypass the busy Main Street. SR 25 Business, a former alignment of SR 25, serves this area. The highway crosses into Portland and immediately interchanges with the Maine Turnpike (I-95) at exit 47, thereafter meeting its business route and proceeding into downtown on Brighton Avenue. SR 25 crosses SR 9 (Stevens Avenue), then turns onto Deering Avenue, crossing over I-295/US 1 without an interchange.