Murder, Inc. was established after the formation of the commission of the National Crime Syndicate, to which it ultimately answered. It was largely headed by mob boss Louis "Lepke" Buchalter and Mangano Family underboss Albert Anastasia, but also had members from Buchalter's labor-slugging gang (in partnership with Tommy "Three-Fingered Brown" Lucchese) as well as from another group of enforcers from Brownsville, Brooklyn, New York led by Martin "Buggsy" Goldstein and Abe "Kid Twist" Reles. Buchalter, in particular, and Joe Adonis occasionally, gave the outfit its orders from the board of directors of the syndicate. Albert "The Mad Hatter" Anastasia was the troupe's operating head, or "Lord High Executioner", assisted by Lepke's longtime associate Jacob "Gurrah" Shapiro.