One of the earliest and most comprehensive accounts of social structure was provided by Karl Marx, who related political, cultural, and religious life to the mode of production (an underlying economic structure). Marx argued that the economic base substantially determined the cultural and political superstructure of a society. Subsequent Marxist accounts, such as that of Louis Althusser, proposed a more complex relationship that asserted the relative autonomy of cultural and political institutions, and a general determination by economic factors only "in the last instance."