The song received generally mixed reviews from contemporary music critics, who found that "Lock U Down" sounded dated and a poor choice as a single. The song was a commercial disappointment, it failed to chart on "Billboard"s Hot R&B/Hip-Hop Songs chart; peaking below the chart at number one hundred and number one on the Bubbling Under R&B/Hip-Hop Songs chart only. The song’s accompanying music video was filmed by director Benny Boom. It featured Harrison and Lil Wayne in abandon warehouse. The video made its world premiere on BET’s "106 & Park" on April 25, 2007.