After an upset loss to the Vikings, the Chargers faced the defending Super Bowl champions in San Diego following their first loss of the season to the New England Patriots. Darren Sproles return the opening kickoff 89 yards for a touchdown. After a Nate Kaeding field goal, Sproles returned a punt 45 yards for his second special teams touchdown of the game with less than 6 minutes left in the first quarter. The PAT snap wasn't held and the PAT failed. Peyton Manning threw four interceptions in the first quarter alone. In the second quarter the Chargers put together a 45-yard drive resulting in a 4-yard touchdown run by LaDainian Tomlinson. Manning was able to score a touchdown to Reggie Wayne leaving the score 23–7 at halftime.