Tony Bill discovered Tom Sierchio's screenplay for "Untamed Heart" during one of his talent searches: he had asked an agent at William Morris to send him screenplays from new writers. Originally, Sierchio's screenplay had been submitted as a writer's sample. Bill showed the screenplay to producer Helen Bartlett who suggested that they option it. Within two weeks of Sierchio handing his script to his agent, MGM had greenlighted the project. The film was originally titled "The Baboon Heart" in honor of an infant named Baby Fae (born 14 October 1984) who received a cross-species heart transplant from a baboon to fix a congenital heart defect.