Nichols starred in the science-fiction thriller "Pandemic" (2016) as a doctor who leads a group to find survivors of a worldwide pandemic. The film was released for selected theaters and VOD, and in its review, "The Hollywood Reporter" remarked that Nichols "attempts to adopt an attitude somewhere between shell-shocked survivor and sympathetic physician, but doesn't manage to fulfill the role's potential". In "Inside" (2016), a Spanish-American remake of the 2007 French horror film of the same name, Nichols took on the starring role of a pregnant woman accosted in her home by an unknown woman who intends to steal her baby. The film was released in Spain cinemas on July 28, 2017, where it made US$557,083, and in the United States on January 12, 2018. Nichols next obtained another recurring role on television as a former guardian who has been thrust back five centuries into the past to finally move forward, in the fourth season of the TNT fantasy series "The Librarians". For her four-episode performance, she received a Saturn Award nomination for Best Guest Starring Role on Television.