State Route 501 (SR 501) is a north–south state highway in Auglaize and Allen counties, Ohio. The southern terminus of SR 501 is at an interchange with U.S. Route 33 (US 33) just south of Wapakoneta, which is also the western terminus for SR 67 and the southern terminus for SR 198. The route runs concurrently with both of the latter two routes into Wapakoneta, and with SR 198 only north of the city. SR 501’s northern terminus is at SR 117 approximately west of Lima.