Cassandra did not make an appearance in "Soulcalibur V", although she was mentioned in the official artbook of the game. According to the artbook, at the conclusion of "Soulcalibur IV", she arrived at the Ostrheinsburg Castle and found out that Sophitia had pledged her service to Soul Edge to save Pyrrha, who spent too much time around Soul Edge and had to rely on the sword to survive. Sophitia rendered Cassandra unconscious with a single strike, wounding her greatly. When she awakened, she found that the entire castle was disintegrating into a realm called Astral Chaos. Now weakened, Cassandra found Sophitia's unconscious body in a room, but as she approached her, Cassandra was sucked to the Astral Chaos while the castle returned to normal, as she was too wounded to escape. Due to being stranded in the Astral Chaos, Cassandra died, and her soul went into despair and became infested with evil, losing the memories of her own original identity, and keeping only her desire to save her sister.