On 25 August 2018, Cavani played his first game of the season after missing PSG's first three games following his injury at the 2018 World Cup. The front three of Cavani, Neymar and Mbappé all scored in a 3–1 league win over Angers at home, with Cavani scoring the opener from Neymar's assist. On 11 November 2018, Cavani scored a hat-trick in a 4–0 win over Monaco. On 18 December, Cavani scored in PSG's 2–1 win over Orléans in the Coupe de La Ligue; this was his 15th goal all-time in the competition, tying Pauleta's record for most goals in the tournament.