NY 374 begins at an intersection with U.S. Route 11 (US 11, named Main Street), where it follows Depot Street and becomes maintained by the New York State Department of Transportation (NYSDOT). The route continues southward out of Chateaugay and back into the local forests and fields, where it passes to the east of High Falls Park. At the intersection with Pulpmill Road, NY 374 continues to the southeast, losing any sight of development around the highway. The route parallels Healey Road and intersects with Number Five Road, where the highway moves around in different directions. The route continues along the Chateaugay River and into Brainardsville, where it intersects with NY 190 (Military Turnpike) and CR 24 (Brainardsville Road). The route leaves Brainardsville shortly after the intersection with Reynolds Road.