Long-term persistence of this species will probably require well-planned fire management regimes within its habitat, throughout its range. Prescribed burning is currently conducted for a variety of reasons including protection of human life and property, and habitat management. Management for the New Holland mouse should be incorporated into appropriate NRE fire protection plans. The New Holland mouse occurs in association with other native mammals including the brown antechinus ("Antechinus stuartii"), white-footed dunnart ("Sminthopsis leucopus"), southern brown bandicoot ("Isoodon obesulus"), bush rat ("Rattus fuscipes"), swamp rat ("Rattus lutreolus") and Eastern pygmy possum ("Cercartetus nanus"). Activities such as prescribed burning may not always benefit these species, nor the many other vertebrates, invertebrates, plants and other organisms present. Nevertheless, regimes could be formulated to adequately cater for some specific requirements, given that there is sufficient area of habitat. Small-scale mosaic burns should not endanger other vertebrate species at a local level, and may benefit native plants.