What is now PA 152 was originally Limekiln Road, a road built to transport lime from area kilns. The road was a turnpike between the 1850s and 1917. The route was first designated in 1928 to run from U.S. Route 611 (US 611) in North Philadelphia to PA 113 in Silverdale. PA 152 was extended north to US 309 in Sellersville in 1946, replacing the former routing of PA 413 between Perkasie and Sellersville. By 1960, the southern terminus of the route was cut back to its current location. PA 152 was extended west to end at PA 309 near Telford by 1970.