Hesketh has received numerous commissions from international ensembles and organisations including the Fromm Foundation at Harvard University, the Continuum Ensemble, a Faber Millennium Commission for the Birmingham Contemporary Music Group, the BBC Philharmonic, Hans Werner Henze and Endymion (in honour of Henze's 75th birthday), the Munich Biennale, the Michael Vyner Trust for the London Sinfonietta, an ENO/Almeida joint commission, Ensemble 10/10 and the Opera Group at the Linbury Theatre, Covent Garden. Performances have been given by the Frankfurt Radio Symphony Orchestra (Hessicher Rundfunk), the Sudwest Rundfunk (Baden-Baden), the London Sinfonietta, Psappha, the ASKO ensemble, the Continuum Ensemble (Spitalfields Festival), as well as featured at the Prague Premieres (Czech Philharmonic Orchestra)"," ISCM (Korea) and Gaudeamus Festivals. Conductors include Sir Simon Rattle, Oliver Knussen, Martyn Brabbins, Patrick Bailey, Philip Headlam, Christoph-Mathias Mueller, Vassily Sinaisky and Vasily Petrenko. Soloists include violinists Simon Blendis, Clio Gould, Peter Sheppard-Skaerved and Janet Sung, oboists Nicholas Daniel, Christopher Redgate and Hansjorg Schellenberger, sopranos Sarah Leonard, Claire Booth and Marie Vassiliou, baritone Rodney Clarke and pianists Karl Lutchmayer, Sarah Nichols and Daniel Becker.