The game begins at Montsaye High, an abandoned school in Detroit, where Detective Lazarus Jones (voiced by Rob Paulsen) of the Detroit Police Department is on his first day on the job. He is on a routine call with his partner, Anna Steele (Nan McNamara), to investigate reports of unusual sounds in the building. Steele explains that several years previously, a professor murdered ten students, and then disappeared. He was never found, nor was any murder weapon, and the coroner was unable to determine the cause of death of any of the victims. After the two split up to investigate the building, Jones discovers a laboratory in the basement. He presses a switch on a machine, which seems to release a gas of some kind. He is knocked out and when he regains consciousness, he goes to meet Steele in the sewers. However, before he can prevent it, Steele is dragged into a pipe by a transparent man.