In 2005, astrobiologist Chris McKay argued that if methanogenic life did exist on the surface of Titan, it would likely have a measurable effect on the mixing ratio in the Titan troposphere: levels of hydrogen and acetylene would be measurably lower than otherwise expected. Assuming metabolic rates similar to those of methanogenic organisms on Earth, the concentration of molecular hydrogen would drop by a factor of 1000 on the Titanian surface solely due to a hypothetical biological sink. McKay noted that, if life is indeed present, the low temperatures on Titan would result in very slow metabolic processes, which could conceivably be hastened by the use of catalysts similar to enzymes. He also noted that the low solubility of organic compounds in methane presents a more significant challenge to any possible form of life. Forms of active transport, and organisms with large surface-to-volume ratios could theoretically lessen the disadvantages posed by this fact.