He married Rebecca Nnana Mochedibane, whose family was a victim of forced removals in Vrededorp, in 1945 (the same year his mother died). A qualified social worker with a diploma from Jan Hofmeyer School, in Johannesburg, she and Mphahlele would have five children. When he went into exile from South Africa, he left behind his entire extended family, except for his wife and children, going for years without seeing them. While in Nigeria, he once tried taking advantage of a British passport before Nigerian independence. He applied for a visa through the consulate in Nairobi, in order to visit his younger brother Bassie (Solomon) who was ill with throat cancer, but his application was turned down.