Pearce was established in 1967 with a group of tenth graders housed at Richardson North Junior High School. Prior to 1967, all high school students in the Pearce area attended Richardson High School. In 1969, the school moved to its current home on Coit Road; the campus has been expanded several times since. Along with Berkner High School, it is one of two RISD high schools to have a natatorium. While Pearce hosts a natatorium, Eagle-Mustang Stadium is shared with Richardson High School. An indoor training facility was built in 2018 to accommodate Pearce athletes.