Melanoma accounts for approximately one percent of skin cancer, and causes most of skin cancer-related deaths. The average age of diagnosis is 63, and it is the most common cancer in the 25–29 age group and the second most common in the 15-29 group, which may be due in part to the increased UV exposure and use of indoor tanning observed in this population. In the United States, the melanoma incidence rate was 22.3 per 100,000, based on 2010-2014 data from the National Institutes of Health Surveillance, Epidemiology and End Results (SEER) Program, and the death rate was 2.7 per 100,000. 9,730 people were estimated to die of melanoma in the United States in 2017, and these numbers are anticipated to continue rising. Although 91.7% of patients diagnosed with melanoma survive beyond 5-years, advanced melanoma is largely incurable, and only 19.9% percent of patients with metastatic disease survive beyond 5 years. An international meta-analysis performed in 2014 estimates that annually, 464,170 cases of skin cancer can be attributed to exposure to indoor tanning.