Alzheimer's disease: As Alzheimer's disease becomes more serious, less working memory functions. There is one study that focuses on the neural connections and fluidity of working memory in mice brains. Half of the mice were given an injection that is similar to Alzheimer's effects, and the other half were not. Then they were expected to go through a maze that is a task to test working memory. The study help answer questions about how Alzheimer's can deteriorate the working memory and ultimately obliterate memory functions.