Cavani scored on his Uruguay debut against Colombia on 6 February 2008, and has since then earned 117 caps and scored 51 international goals, only fewer than strike partner Luis Suárez among Uruguayan internationals. He has participated in eight major international tournaments: the 2010 FIFA World Cup, the 2011 Copa América, the 2013 FIFA Confederations Cup, the 2014 World Cup, the 2015 Copa América, the Copa América Centenario, the 2018 FIFA World Cup and the 2019 Copa América. He scored once at the 2010 World Cup to help Uruguay to fourth place in the tournament, and in 2011 was part of the Uruguay squad that won a record 15th Copa América title. He finished as the CONMEBOL 2018 World Cup qualification top scorer with 10 goals.