Granada turned professional in June 2005 at age 18 and competed on the Futures Tour that summer, joining in mid-season. She placed second in her first and sixth events and won her first professional title at the season-ending YWCA Futures Classic in late August in York, Pennsylvania. Granada won $29,153 in nine Futures Tour events to finish seventh on the 2005 money list, which advanced her to the final stage of the LPGA qualifying tournament in December. She finished tied for sixth in the five-round event to earn her LPGA card for 2006.