Within the rest of Jacksonville, the road intersects state highways such as SR 134 (103rd Street), and later serves as the eastern terminus of SR 208 (Wilson Boulevard), where SR 21 has a wide median as opposed to a center turn lane. Two blocks north of SR 208, Blanding Boulevard crosses over the Cedar River, a tributary of the Ortega River, and enters Lake Shore. Two blocks north of the bridge, the road intersects with the southern terminus of SR 111 (Cassat Avenue). SR 21 heads northeast for several blocks until its intersection with the east-west connector San Juan Avenue SR 128.