Kellerman's acting career spans over 60 years. Her role as Major Margaret "Hot Lips" Houlihan in Robert Altman's film "M*A*S*H" (1970) earned her an Oscar nomination for Best Actress in a Supporting Role. After "M*A*S*H", she appeared in a number of the director's projects: the films "Brewster McCloud" (1970), "Welcome to L.A." (1976) (produced by Altman, directed by his protege, Alan Rudolph), "The Player" (1992) and "Prêt-à-Porter" (1994), and the short-lived anthology TV series "Gun" (1997). In addition to her work with Altman, Kellerman has appeared in films such as "Last of the Red Hot Lovers" (1972), "Back to School" (1986), plus many television series such as "The Twilight Zone" (1963), "The Outer Limits" (1965), ' (1966), "Bonanza" (1966, 1970) "The Minor Accomplishments of Jackie Woodman" (2006), "90210" (2008), "Chemistry" (2011), and "Maron" (2013). She also voiced Miss Finch in ' (1985).