Amell's first role was Daniel Murtaugh in "Cheaper by the Dozen 2", which was filmed in the Muskoka Region of Ontario. Originally meant to be a non-speaking role, he ended up getting a couple of lines. He also appeared in the 2007 horror film "Left for Dead". Amell had a role in the Canadian Family Channel series "Life with Derek", playing lead character Casey McDonald's boyfriend Max. "Life with Derek" was distributed worldwide, including US Disney Channel and its international affiliates. He has also appeared in the ABC Family film "Picture This". Amell had a recurring role on both the Nickelodeon series "True Jackson, VP" as Max Madigan's nephew Jimmy, True's love interest, and the Cartoon Network series "Unnatural History".