On that duty when the United States entered World War II, "Roe" headed south in January 1942, patrolled the approaches to Bermuda and to Norfolk, Virginia, and in mid-February entered New York harbor, where she resumed North Atlantic convoy runs. Arriving off Iceland on 3 March, she remained until midmonth, in port and on patrol off that island and in the Denmark Strait. Toward the end of the month, "Roe" returned to New York. In April, she escorted ships to Panama, then spent May in New England waters. In June, she completed another North Atlantic run, this time to the United Kingdom, and in July, she screened larger ships in coastal and Caribbean Sea training operations.