In 2000 he was named Minnesota's starting quarterback. He led the Vikings to victory in the first seven games of the season, and helped them finish 11–5 and advance to the NFC Championship game, where they were blown out by the New York Giants 41–0. During the season, Culpepper passed for 3,937 yards, 33 touchdowns and 16 interceptions. He also rushed for 470 yards and seven touchdowns. One of Culpepper's most notable moments was against the Buffalo Bills when he threw a pass across his body and the field to Randy Moss for a 39-yard touchdown pass, although the pass was at least 60 total yards. At the end of the year, he was selected to his first Pro Bowl. Randy Moss, wide receiver for the Vikings, said that Culpepper was one of the most talented quarterbacks he has ever seen following the 2000 season.