Shrewsbury was succeeded by his son from his first marriage to Lady Gertrude Manners, the seventh Earl. He represented Derbyshire in the House of Commons and served as Lord Lieutenant of Derbyshire. He had no sons and on his death in 1616 the baronies of Talbot, Strange of Blackmere and Furnivall fell into abeyance between his three daughters. He was succeeded in the earldoms by his younger brother, the eighth Earl. He was Member of Parliament for Northumberland. He did not have a male heir either and was succeeded by his distant relative, the ninth Earl. He was the great-great-grandson of Sir Gilbert Talbot (died 1518), third son of the second Earl of Shrewsbury. The family bought Barlow Woodseats Hall in 1593 as part of the estate.