Finding work in a male-dominated field was difficult for her, so she began her career as a costume designer for theater actresses, a field more common for women at the time. In 1923 she was commissioned to decorate the dome of the National Academy of Sciences in Washington, D.C. by architect Bertram Grosvenor Goodhue. Meiere and sculptor Lee Lawrie became members of the loose "repertory company" of artists assembled by Goodhue, and she came to work on many different projects with him. One of these, the Nebraska State Capitol in Lincoln, which she began before the NAS dome was even completed, became her pièce de résistance featuring eight separate examples of her work.