After sitting Rep. Sherrod Brown of Ohio's 13th congressional district declared his intention to run against Mike DeWine for his seat in the U.S. Senate, Sutton took part in the Democratic primary for his open seat. She defeated notables such as former U.S. Rep. Thomas C. Sawyer, who had previously been redistricted out of Congress, and Capri Cafaro, who had run against Rep. Steven LaTourette in the neighboring 14th District during the previous election cycle. Sutton capitalized on the anti-corruption theme of Ohio's 2006 elections to make a strong showing late in the primary season, and held it to win the primary with the strong support of organized labor.