In 1939, Karlgren succeeded Johan Gunnar Andersson as director of the Museum of Far Eastern Antiquities (Östasiatiska Museet), a post he held until 1959. This public museum was founded in 1926 on Andersson's pioneering discoveries of prehistoric archaeology made in China in the 1920s, and later expanded to cover later periods as well as other parts of Asia. Karlgren had been in close contact with Andersson for many years, and also succeeded Andersson as editor of the museum's journal, the "Bulletin of the Museum of Far Eastern Antiquities" (BMFEA, 1929–) and continued in this position until the 1970s. Karlgren himself first published many of his own major works in this annual journal, or as books in the monograph series of the museum.