At the midway point of the season, Bush had yet to score a touchdown either receiving or running the ball; however, on November 12, 2006, Bush rushed for his first touchdown from scrimmage on a reverse against the Pittsburgh Steelers. On December 3, Bush tied the Saints' single-game touchdown record, held by Joe Horn, by scoring four touchdowns against the San Francisco 49ers. He gained 168 all-purpose yards as he sparked the Saints to their eighth win of the season. On December 10, Bush scored a 62-yard touchdown against the Dallas Cowboys in Dallas, contributing to the Saints' 42–17 drubbing of the Cowboys in what was expected to be a more competitive matchup that would be important to the playoff race. On December 24, Bush scored a one-yard touchdown on a reverse against the New York Giants. Bush also had a career-high 126 rushing yards on the day. On December 31, Bush scored a one-yard touchdown against the Carolina Panthers but carried the ball only three times, even though backfield counterpart Deuce McAllister did not play. This was because the New Orleans Saints had already clinched the No. 2 NFC seed in the playoffs.