A rematch between Melendez and Tatsuya Kawajiri took take place on April 9, 2011 at Strikeforce 33 in April. Melendez dominated his opponent showing excellent striking, knocking down Kawajiri with a right hand near the beginning of the fight. Melendez then again knocked down Kawajiri with a combination of knees to the body and a right hook followed by a right uppercut. The beginning of the end came when Melendez sprawled one of Kawajiri's takedowns and then began landing short left hands which knocked Kawajiri down into half-guard where Melendez began landing vicious right elbows before the referee stopped the fight declaring Melendez the winner by TKO 3:14 into the first round.