As part of the "All-New, All-Different Marvel" Madame Masque starts a quest to retrieve different magical objects in order to empower herself. During her journey, she is pursued by a mysterious group of ninjas. Iron Man catches onto her motives when she tries to steal a duplicate Wand of Watoomb from Castle Doom. Upon discovering the artifact she had stolen is fake, she kills her informant in a hotel in Montreal. Iron Man later confronts Madame Masque in the hotel room and tries to reason with her. Startled by his presence, Madame Masque unleashes a surprising display of enormous magical power. Upon traveling to Mary Jane Watson's nightclub, Jackpot, in Chicago, Madame Masque confronts her former business partner Belhilio and kills him. She then faces off against Iron Man and Doctor Doom, which results in the nightclub being completely trashed. A furious Watson hits her in the face with a microphone, knocking her mask off, and Doctor Doom discovers that Madame Masque has been demonically possessed. Iron Man is able to hold her down while Doctor Doom successfully performs an exorcism. By the time Iron Man regains consciousness, Doctor Strange arrives and informs him that he will take Madame Masque away to metaphysically fix her and will later hand her over to the custody of S.H.I.E.L.D.