On April 15, 1978, an accident involved units E.645.016 and E.636.282 in Murazze di Vado (in the province of Bologna). The train hauled by the two locomotives derailed due to damage to the line caused by a landslide, and ended poised over a slope. When the first rescue had already arrived, both locomotives were hit by an ALe 601 railcar on the express service "Freccia della Laguna"; the railcar coaches fell into the slope, while the locomotives piled up one on top of the other on their sides. The accident caused 32 deaths and 120 wounded.