David Quammen reviewed "The Ghost Map" (2006) for "The New York Times", writing, "There's a great story here, one of the signal episodes in the history of medical science, and Johnson recounts it well... His book is a formidable gathering of small facts and big ideas, and the narrative portions are particularly strong, informed by real empathy for both his named and his nameless characters, flawed only sporadically by portentousness and small stylistic lapses." He called the book, and Johnson, "intriguing" and "smart."