Normal functioning of the kidney, brain, liver, heart, and numerous other systems can be affected by uranium exposure because, in addition to being weakly radioactive, uranium is a toxic metal, although less toxic than other heavy metals, such as arsenic and mercury. It is weakly radioactive but is 'persistently' so because of its long half-life. The Agency for Toxic Substances and Disease Registry states that: "to be exposed to radiation from uranium, you have to eat, drink, or breathe it, or get it on your skin." If DU particles do enter an individual, the type of danger presented—toxic vs. radiological—and the organ most likely to be affected depend on the solubility of the particles.