SD 22 continues to the east through rural areas of the county. East of 475th Avenue, it enters the southern part of Clear Lake. It has an intersection with SD 15. Just after leaving Clear Lake, it crosses over Hidewood Creek. Just to the east of 476th Avenue, it curves to the southeast to travel around the southeastern part of Clear Lake. Just west of Clear Lake Road, it begins to curve to the east-northeast. Just west of 479th Avenue, it curves to the east again. Just west of 485th Avenue, it crosses over Cobb Creek. Just to the east of this intersection is a second crossing of this creek. Just west of 486th Avenue, the highway curves to the east-northeast. Along a curve to the south-southeast, it intersects the southern terminus of SD 101. It crosses over Cobb Creek for a third time and then curves to the south-southwest. Just north of County Road 22A (CR 22A; 478th Avenue), the highway curves back to the east. Just east of 184th Street, it reaches its eastern terminus, at the Minnesota state line. Here, the roadway continues as Minnesota State Highway 68 (MN 68).