Due to injuries to both Wojciech Szczęsny and Łukasz Fabiański, Mannone was the first choice goalkeeper, playing the full 90 minutes in a 0–0 draw against Stoke City, and keeping another clean sheet a week later against Liverpool at Anfield. Mannone also played in a 1–1 draw against Manchester City on 23 September. Due to his performances this season Mannone stated he was ready to challenge Szczęsny for the number one spot. He effectively succeeded Fabiański for the number two spot.