Matthew Van Helsing, a descendant of 19th-century Dutch physician Abraham Van Helsing, owns an antique shop built over the site of Carfax Abbey in London in 2000. One night, with Van Helsing upstairs, his secretary, Solina, allows a group of thieves, led by her boyfriend, Marcus, into the shop. The thieves infiltrate the shop's underground high-security vault and find a sealed silver coffin protected by a deadly defense system. Based on the level of security surrounding the coffin, Solina and Marcus decide that the coffin must contain valuable content, so they escape with it and flee to New Orleans. When Van Helsing discovers that the coffin has been stolen, he boards a plane to America, telling his apprentice, Simon Sheppard, to remain in London. Simon, ignoring these instructions, follows his mentor.