Regardless of the mechanism of fibrosis or the origin of myofibroblasts, exogenous BMP-7 has been shown to reverse the EMT process and trigger MET. Eventually this restores the healthy epithelial cell population, and normal function of the kidneys in mice. This is pertinent in humans as well, because many diseases stemming from organ fibrosis occur via the EMT process. The epithelial-menenchymal transition is also problematic in cancer metastasis, so the diminution of EMT with recombinant DNA could have great implications in future cancer treatment options.