In 2000, Tourniquet began writing more thrash-oriented songs again. They signed directly to Metal Blade Records, and began work on "Microscopic View of a Telescopic Realm", their most technical album since "Pathogenic Ocular Dissonance". The aforementioned albums generated comparisons to each other, and "Microscopic View of a Telescopic Realm" contained a sequel to the "Pathogenic Ocular Dissonance" song "The Skeezix Dilemma" titled "The Skeezix Dilemma Part II - The Improbable Testimony of the Pipsisewah". The album received rave reviews from both fans and critics.