In 1820, the Old Stone Schoolhouse at Dunraven was built. By 1831, Charles Poldino had begun the practice of medicine. Dr. Poldino was also made first postmaster in June 1848, when Margaretville was designated as a post office station. It was actually a small addition made onto the G.G. Decker store. In 1850, the village was named in honor of Margaret Lewis (Livingston's granddaughter). Until then, it had been known as "Middletown Center", which took its name from its location, equidistant from the Hudson, Delaware and Susquehanna rivers. It is one of the oldest towns in Delaware County. On May 8, 1875, the village became incorporated.