In March 2019, manager Óscar Tabárez included Cavani in the final 23-man Uruguay squad for the 2019 Copa América in Brazil. On 16 June, Cavani scored "an acrobatic bicycle-kick" in a 4–0 win over Ecuador in the team's opening group match of the tournament; this was his first goal ever in the Copa América. In the quarter-finals against Peru on 29 June, he had a goal disallowed by VAR for offside in regulation time; following a 0–0 draw, the match went to a penalty shoot-out. Although Cavani was able to convert his spot-kick, Peru won the shoot-out 5–4, which saw Uruguay eliminated from the competition.