Jackson started the 2010 season with 81 rushing yards in a 17-13 loss to the Arizona Cardinals. He rushed for over 100 in three consecutive games against the Detroit Lions, San Diego Chargers, and the Tampa Bay Buccaneers. Jackson surpassed Eric Dickerson as the Rams' all-time leading rusher, with a 110-yard effort against the Buccaneers game. On November 21, 2010, he recorded his 10,000th career yard from scrimmage on a first quarter run against the Atlanta Falcons. Jackson rushed for 1,145 yards during the 2011 regular season, marking the seventh consecutive season he has surpassed 1,000 yards. He earned his third Pro Bowl nomination for the 2010 season. He was ranked 38th by his fellow players on the NFL Top 100 Players of 2011.