The region was only intermittently inhabited by Native Americans until relatively recent times, and no single tribe had exclusive use of the Jefferson River when the Lewis and Clark Expedition first ascended the river in 1805. Today, the Jefferson River retains much of its scenic beauty and wildlife diversity from the days of Lewis and Clark, yet is threatened by water use issues and encroaching development. The Jefferson is a segment of the Lewis and Clark National Historic Trail, administered by the National Park Service.