Continuing east from the US 281 interchange, the freeway has interchanges with several local roads to include Gold Canyon Drive, Redland Road, Bulverde Road, and O'Connor Road. The freeway continues east to interchanges with Judson Road and Green Mountain Road before it curves to head to the southeast. Now heading southeast, the freeway has an interchange at FM 2252 near Rolling Oaks Mall and an interchange at Lookout Road before it leaves the San Antonio city limits. Upon leaving San Antonio, the freeway enters the Live Oak city limits before a cloverleaf interchange at I-35. Southeast of I-35, Loop 1604 enters the Universal City city limits before reaching an interchange with SH 218, which provides access to Randolph Air Force Base. Between the interchange at SH 218 and Kitty Hawk Road, Loop 1604 has a couple at-grade turn-offs at Palisades Drive and Granada Drive. At-grade turn-offs southeast of the Kitty Hawk Road interchange are located at Meadowland Drive and Byrd Boulevard. The last two interchanges of the freeway are located at FM 1976 and FM 78. The highway merges down to a two-lane road as it enters the Converse city limits. The highway passes by the western boundary of Randolph Air Force Base before curving to the south. The highway re-enters San Antonio city limits prior to its interchange at I-10 at its official beginning and end.