The degrading structure of Isbell resulted in some weakening as it accelerated toward Florida. At 22:00 UTC on October 14, the hurricane made landfall near Everglades City as a Category 2 with sustained winds between 100 and 110 mph (160 and 175 km/h). Within five hours, the system cleared the Florida Peninsula and emerged over the western Atlantic Ocean north of West Palm Beach. The storm's passage over land resulted in notable weakening, though Isbell remained of hurricane-strength. During the afternoon of October 15, the low that had formed the previous day induced a northward turn of the cyclone and directed it toward North Carolina, a result of what is known as the Fujiwhara effect. Thereafter, the two systems began to intertwine as Isbell began transitioning into an extratropical cyclone; rapid weakening accompanied this phase. Isbell completed this process by 12:00 UTC on October 16 as it moved onshore near Morehead City, North Carolina. On October 17 the two non-tropical systems merged into a single storm over the Outer Banks. Isbell's remnants emerged back over the Atlantic Ocean on October 18 near the Delmarva Peninsula before accelerating northeast. The system was last noted on October 19 as it moved over Atlantic Canada.