In Granville, NY 22 was originally routed on Quaker, Main, and North streets. It was rerouted in the mid-1960s to bypass Granville on a new highway west of the village. NY 149 was then extended northward along NY 22's former routing to the junction of Main and North streets in Granville. From there, it continued eastward on Main Street to reach the Vermont state line, where it connected to VT 30B, a spur route of VT 30 that had been in place since 1935. Vermont renumbered VT 30B to VT 149 in December 1966 to match the highway it now connected to in New York. (equivalent to $ in ).