A second century AD manuscript by the Greek physician and gynecologist Soranus of Ephesus dealt with neonatal pediatrics. The Byzantines also built "brephotrophia" (crêches). Islamic Golden Age writers served as a bridge for Greco-Roman and Byzantine medicine and added ideas of their own, especially Haly Abbas, Yahya Serapion, Abulcasis, Avicenna, and Averroes. The Persian philosopher and physician al-Razi (865–925) published a monograph on pediatrics titled "Diseases in Children" as well as the first definite description of smallpox as a clinical entity. Also among the first books about pediatrics was "Libellus de aegritudinibus et remediis infantium" 1472 ("Little Book on Children Diseases and Treatment"), by the Italian pediatrician Paolo Bagellardo. In sequence came Bartholomäus Metlinger's "Ein Regiment der Jungerkinder" 1473, Cornelius Roelans (1450–1525) no title Buchlein, or Latin compendium, 1483, and Heinrich von Louffenburg (1391–1460) "Versehung des Leibs" written in 1429 (published 1491), together form the "Pediatric Incunabula", four great medical treatises on children's physiology and pathology.