With the creation of the U.S. Highway System on November 11, 1926, US 13 was designated through Maryland from the Virginia border south of Pocomoke City north to the Delaware border in Delmar. The route headed north to Pocomoke City, northwest to Westover, north to Princess Anne, northeast to Fruitland and Salisbury, and north to Delmar. The entire route of US 13 in Maryland became part of the Ocean Highway, an Atlantic coastal highway stretching from Jacksonville, Florida to New Brunswick, New Jersey that served as the quickest route between the New York City area and Florida before the introduction of the Interstate Highway System. US 13 is one of only four U.S. Routes that form the highway and Maryland was one of the states that participated in the highway's formation.