At the intersection with Squirrel Lane, PA 63 briefly forms the border between the borough of Lansdale to the northeast and Towamencin Township to the southwest before fully entering Lansdale and becoming Main Street. The road passes a mix of homes and businesses, coming to a junction with the northern terminus of PA 363 (Valley Forge Road). After the PA 363 junction, the road runs through the downtown area of Lansdale, where the route crosses SEPTA's Lansdale/Doylestown Line at-grade south of the Lansdale station and intersects Broad Street. The road leaves the downtown and heads into areas of homes and businesses. At a crossing of Wissahickon Creek, PA 63 forms the border between Lansdale to the northeast and Upper Gwynedd Township to the southwest before running along the border of Montgomery Township and Upper Gwynedd Township after crossing North Wales Road.