During his time at college, Lusinchi stood out as a political activist, was secretary of the School Medicine Council, vice president of the Venezuelan Association of Youth and vice president of the Student Federation of Venezuela - an organization with Marxist influences that became part of the "19 October 1945" revolutionary movement which overthrew the government of Isaías Medina Angarita. In 1948, he was elected president of the Municipal Council of Freites District and president of the Legislative Assembly of Anzoátegui, as well as regional secretary of Acción Democrática.