Guy was named defensive coordinator and linebackers coach at the University of Tulsa on January 21, 2011. In 2012, the Golden Hurricane went on to win the Conference USA Championship and finished ranked in the top 25 after defeating Iowa State in the Liberty Bowl 31–17. That year, Tulsa's defense set school records in sacks and tackles for loss, finishing second and third in the nation respectively. Tulsa finished the season ranked in the top 25 in defense. In each of his first three seasons at the school, a Golden Hurricane linebacker earned first-team All-Conference USA honors—Curnelius Arnick (2011), DeAundre Brown (2012), and Shawn Jackson (2013). Jackson, who was also named the 2013 Conference USA defensive player of the year, finished his career as Tulsa's all-time leader in sacks (23.5) and tackles for loss (55.5), and second all-time in tackles (409). In Guy's final three years as the defensive play-caller, University of Tulsa ranked ninth in the country for total TFL's, averaging 6.8 per game.