After crossing the Pasig River, EDSA enters the city of Makati through Guadalupe, where it provides access to the Rockwell Center, a major mixed-use business park in Makati, through J.P. Rizal Avenue. The highway also provides quick access to the city of Taguig and the Bonifacio Global City nearby. After crossing Buendia Avenue, the highway enters the Ayala Center, an important commercial district in the Philippines, where the Greenbelt and Glorietta shopping centers are located. The road then curves eastwards, continues on a straight route to the city of Pasay, and passing the Osmeña Highway and South Luzon Expressway (SLEX) through Magallanes Interchange.