Ankiel hit his first grand slam in St. Louis against left-hander Eddie Guardado of the Cincinnati Reds on August 31 with the team trailing, 4–3, for an 8–5 win that broke a tie with Red Schoendienst for La Russa for most wins by a Cardinals manager. In a home game against the Pittsburgh Pirates on September 6, he recorded his second two–home run game of the season with a 3-for-4, 7-RBI effort, along with an over-the-shoulder catch in deep right field. On September 23, Ankiel had his first walk-off hit, a two-run triple to win the last "Sunday Night Baseball" game of the season – against the Astros, 4–3.