At the French Open, Nalbandian suffered a shock loss in the second round to Frenchman Jérémy Chardy. After being two sets up and seemingly in control, he lost the next three to hand Chardy the win 6–3, 6–4, 2–6, 1–6, 2–6. He also suffered early exits from both Wimbledon and the US Open, losing in the second round and third round, respectively. His indoor season, however, was a success, as he won his ninth career title at the 2008 Stockholm Open, defeating Robin Söderling 6–2, 5–7, 6–3, in the finals. He was defending champion at the Madrid Masters but was quickly eliminated by fellow Argentine Juan Martín del Potro in the third round. He then entered both the Davidoff Swiss Indoors and the BNP Paribas Masters, where he was once again the defending champion. He did not win either of these tournaments but found himself in the finals of both.