When the B&O finally completed track to Wheeling on the navigable Ohio River, Davis was put in charge of the Piedmont station. It was a crucial station because it was at the foot of a mountain, where trains traveling eastward added engines to surmount the slope. Until the railroad completed a house for him (so his new wife could join him), Davis lived in a box car, and also came to admire the natural landscape of the Allegheny Mountains. After four years, his brother Thomas joined him, and they established a store, often trading farm products for manufactured goods such as jeans, shoes, calico and sugar. In 1858, Davis resigned his railroad job to concentrate on the firm, Henry G. Davis & Company.