Coming off their overtime road win over the Titans, the Chargers went home for a Week 15 interconference duel with the Detroit Lions. The Chargers struck first with RB LaDainian Tomlinson getting a 6-yard TD run, Kicker Nate Kaeding getting a 22-yard field goal, and Tomlinson getting a 2-yard TD run. In the second quarter, San Diego continued its domination with Kaeding getting a 22-yard field goal and LB Shaun Phillips returning an interception 18 yards for a touchdown. The Lions got on the board with QB Jon Kitna completing a 9-yard TD pass to WR Brandon Middleton. The Chargers ended the scoring for the half with QB Philip Rivers completing a 1-yard TD run to TE Brandon Manumaleuna.