On May 11, 1980, Kellerman married Jonathan D. Krane in a private ceremony at Jennifer Jones' Malibu home. Claire Anderson Graham, 16, Kellerman's niece/adoptive daughter, was her maid of honor. In May 1987, Krane adopted Claire, and in 1989, Kellerman and Krane adopted newborn twins, Jack Donald and Hannah Vaughan, who were born on June 24 of that year. Jonathan Krane died of a heart attack on August 1, 2016, at the age of 64. Hannah Krane died on October 22, 2016, at the age of 27 from a heroin and methamphetamine overdose.