Acuña made her professional debut on 5 December 1997 against Christy Martin in Pompano Beach, Florida, on an undercard that was headlined by Johnny Tapia's world championship defense against Puerto Rico's Andy Agosto and which was shown nationally across the United States. Acuña was dropped in round ten, but she rose and finished the bout on her feet. Despite losing a unanimous decision by scores of 100-90 and 99-90 (twice), Acuña's performance was hailed by many fans and critics alike, considering that this was her first professional boxing bout.