He was originally signed by the Green Bay Packers as an undrafted free agent in 2002. Bironas' active professional career began in Arena football where he was a member of the Charleston Swamp Foxes, Carolina Cobras, and the New York Dragons and had intermittent offseason stints with the NFL's Tampa Bay Buccaneers and the Pittsburgh Steelers. In 2005, he signed with the Titans, with whom he played for nine seasons and was an All-Pro and Pro Bowl selection in 2007. Bironas was killed in a car crash on September 20, 2014.