The physical interpretation of the Grassmann-valued coordinates are the subject of debate; explicit experimental searches for supersymmetry have not yielded any positive results. However, the use of Grassmann variables allow for the tremendous simplification of a number of important mathematical results. This includes, among other things a compact definition of functional integrals, the proper treatment of ghosts in BRST quantization, the cancellation of infinities in quantum field theory, Witten's work on the Atiyah-Singer index theorem, and more recent applications to mirror symmetry.