3/7 deployed to Helmand province, Afghanistan from March 2010 to October 2010. During this deployment, the Marines of 3/7 faced daily attacks and operated in various locations including Musa Qaleh, Marjah, and Sangin. In Sangin, 3/7 relieved the 40 Commando of the British Royal Marines and began clearing operations in some of the most dangerous areas of Afghanistan. The Marines of 3/7 encountered heavy resistance and are reported to have experienced some of the highest amounts of enemy contact during the Global War on Terrorism.