His eldest son, Nandamuri Ramakrishna Sr., died in 1962, soon after NTR completed shooting of the film "Irugu Porugu". NTR founded the film studios "Ramakrishna Studios" in Nacharam in his memory. His third son, Nandamuri Saikrishna, who was a theatre owner, died in 2004 following diabetic complications. His fourth son, Nandamuri Harikrishna, who died in a car accident on 29 August 2018, was a child actor-turned-politician elected to the Rajya Sabha, representing the TDP. Harikrishna's sons Nandamuri Kalyan Ram and Jr. NTR are also actors in the Telugu film industry (Tollywood). His sixth son, Nandamuri Balakrishna is one of the leading actors in Tollywood from the mid-1980s. He also started his career as a child artist. Balakrishna has contested 2014 assembly elections as a TDP candidate. He won the Hindupur Assembly Constituency. His seventh son, Nandamuri Ramakrishna Jr. is a film producer.