Williams's resulting film, "The Blood of Jesus" (1941), was produced by his own company, Amegro, on a $5,000 budget using non-professional actors for his cast. It was the first film he directed and Williams also wrote the screenplay. A religious fantasy about the struggle for a dying’ Christian woman’s soul, the film was a major commercial success. Sack declared "The Blood of Jesus" was "possibly the most successful" race film ever made, and Williams was invited to direct additional films for Sack Amusement Enterprises.