De Varona serves on the Executive Board of Special Olympics International and is a member of the International Olympic Committee's Women and Sports Commission. She is also a board member of the International Swimming Hall of Fame and serves as an adviser to Jordan's Prince Feisal's Generations for Peace Foundation and Tony Blair's Beyond Sport Initiative. Most recently, de Varona was appointed to the United States Department of State's Empowerment of Girls and Women through Sports Council by Secretary of State Hillary Clinton. She is also President of DAMAR Productions, a marketing, consulting and events advisory company. She was also the chair of the Athlete Advisory Committee for the 2019 Aurora Games.