Anthony won the first of his 43 PBA titles on June 7, 1970, when he defeated Allie Clarke at the Heidelberg Open in Seattle, Washington. His final PBA title was a major — the 1983 Toledo Trust PBA National Championship (until his 1984 ABC Masters title was added retroactively in 2008). Six of his titles were achieved by a pair of improbable "three-peats" in the PBA National Championship, the first three from 1973–75 and the other three from 1981–83. Earl also finished runner-up to fellow lefty Mike Aulby in the 1979 PBA National Championship.