In "Over and Over", Madonna sings about determination and picking yourself up from disappointments. The song consists of instrumentation from drums, synths and has a three-chord progression. An emotional moment occurred in the recording studio when Madonna covered the 1978 Rose Royce song "Love Don't Live Here Anymore". Rodgers recalled: "Madonna had never performed with a live orchestra before. I was very much into doing everything live, so I just said, 'Madonna, you go out there and sing and we will follow you.' At first Madonna was hesitant, but the live setting ended up producing memorable results. She sang and she was overcome with emotions and she started crying, but I left it on the record." The song features Madonna's vocals supported by acoustic guitars and synth strings, with Thompson playing the drum in the second verse. Towards the end, Madonna emotes in the voice of a soul singer.