On 14 September, Cavani scored the opener in Napoli's first game of their Champions League campaign, a 1–1 away draw at Manchester City. Four days later, on 18 September, he scored a hat-trick against Milan in Napoli's 3–1 home win. On 22 November, Cavani scored both goals in the match winning brace 2–1 at home against Manchester City in the Champions League, leaving Napoli in pole position to follow Bayern Munich into the knockout stage. On 26 November, Cavani scored a 94th-minute equaliser against Atalanta after Napoli went a goal down in the 64th minute through on-loan Napoli striker Germán Denis. On 21 December, Cavani netted a brace in Napoli's 6–1 thrashing of Genoa, helping the "Azzurri" finish 2011 strong and end the first half of the season in sixth place.