In 1980, he began the Marathon of Hope, a cross-country run to raise money for cancer research. He hoped to raise one dollar from each of Canada's 24 million people. He began with little fanfare from St John's, Newfoundland and Labrador, in April and ran the equivalent of a full marathon every day. Fox had become a national star by the time he reached Ontario; he made numerous public appearances with businessmen, athletes, and politicians in his efforts to raise money. He was forced to end his run outside Thunder Bay when the cancer spread to his lungs. His hopes of overcoming the disease and completing his run ended when he died nine months later.