The route leaves South Granville, passing patches of trees and a smattering of homes as it heads toward the border village of Granville. Just south of the village limits, NY 149 intersects with NY 22. NY 22 and NY 149 briefly overlap before NY 22 forks off to bypass Granville to the west. NY 149 continues into Granville, becoming Quaker Street upon entering the village limits. The route proceeds through the village to its center, where NY 149 forks northeastward onto West Main Street and crosses over the Mettawee River. At an intersection with Church Street (CR 26), NY 149 becomes East Main Street and turns to the southeast on its way to the Vermont state line, where the roadway becomes VT 149.