Fletcher made his 300th career appearance for Manchester United on 5 November in a 1–0 home win against Sunderland. Fletcher scored United's second goal in a 2–2 draw with Benfica on 22 November in the Champions League. He met Patrice Evra's cross at the first attempt, which the goalkeeper got a hand to and he followed it up on the second attempt to score. Following this match, he announced that he would be taking an extended break from football following medical advice about his ongoing ulcerative colitis. He did not play again in the 2011–12 season.