US 41 Bus./SR 7 Bus. begins just southeast of Valdosta's city limits, at an intersection with US 41/SR 7/SR 31 (Inner Perimeter Road). The business routes travel to the northwest on South Patterson Street and pass just to the southwest of Payton Park. A short distance later, they intersect the western terminus of SR 94 (Griffin Avenue). Just north of Olympic Park, the southbound and northbound lanes split onto one-way pairs. The southbound lanes continue on Patterson Street, and the northbound lanes travel on Ashley Street. They intersect US 84/US 221/SR 38, which also travel on one-way pairs. The southbound lanes intersect the southern terminus of SR 7 Alt. (North Patterson Street). At West Magnolia Street, the two directions travel together again. US 41 Bus./SR 7 Bus. travel nearly due north, just to the east of Valdosta State University, between Drexel Park and Vallotton Park. Just past East Park Avenue, they curve to the north-northwest and intersect the southern terminus of SR 125 (Bemiss Road). Slightly more than later, the two highways pass by South Georgia Medical Center and then Billy Grant Baseball Field. Next to the Five Points Shopping Center, they intersect the northern terminus of SR 7 Alt. (North Patterson Street). Then, they curve to the west-northwest and meet their northern terminus, another intersection with the US 41/SR 7 mainline.