In 1999 a new virulent race of stem rust was identified that most current wheat strains show no resistance against. The race was named TTKSK (e.g. isolate Ug99), named after the country where it was identified (Uganda) and the year of its discovery (1999). It spread to Kenya, then Ethiopia, Sudan and Yemen, and is becoming more virulent as it spreads. An epidemic of stem rust on wheat caused by race TTKSK is currently spreading across Africa, Asia and the Middle East and is causing major concern due to the large numbers of people dependent on wheat for sustenance. Scientists are working on breeding strains of wheat that are resistant to UG99. However, wheat is grown in a broad range of environments. This means that breeding programs would have extensive work remaining to get resistance into regionally adapted germplasms even after resistance is identified. Similarly, in 2014, Ug99 related race called “Digalu”, was also emerged and devastated Digalu variety in Ethiopia.