Amte founded three ashrams for treatment and rehabilitation of leprosy patients, disabled people and people from marginalised sections of general society in Maharashtra. On 15 August 1949, he and his wife Sadhna Amte started a leprosy hospital in Anandvan under a tree. The leprosy patients were provided with medical care and a life of dignity engaged in agriculture and various small and medium industries like handicrafts. In 1973, Amte founded the Lok Biradari Prakalp to work for the Madia Gond tribal people of Gadchiroli District. Baba Amte also involved in other social cause initiatives like,in year 1985 he launched the first Knit India Mission for peace-at 72 years he walked from Kanyakumari to Kashmir,a distance of more than 3000 miles,to inspire unity among Indian people and organised second march three years later travelling over 1800 miles from Assam to Gujarat. He also participated in Narmada Bachao Andolan in year 1990,leaving Anandwan and lived on banks of Narmada for seven years.