He lost in the first round of the U.S. Open, his last Grand Slam, to Austrian Jürgen Melzer. After a second-round loss in the PTT Thailand Open, he found some late form, coming into the China Open tournament held in Beijing; beating José Acasuso in the first round. In the second round, he played Fernando González and produced a win. In the quarterfinals, he lost against top seed Rafael Nadal. As the tour rolled into Moscow for the Kremlin Cup, it marked the beginning of the end for Safin, as he played his last competitive matches in his native Russia. He defeated No. 6 Nikolay Davydenko in the first round, but lost in the second round. He then played at the 2009 St. Petersburg Open, reaching the semifinals.