Mis is important to the Mule's goal of galactic conquest. He is sought out by the Mule and brought along on with Toran and Bayta Darrell on their journey, still unaware of the Mule's presence. While on Haven, Mis speculates about the nature of the Mule. He and Randu discuss the probability that the Mule is a mutant and if so, what sort of abilities he might have. As they are debating the explanations to the peculiarities that have recently occurred, they come very close to the truth, but they do not realise that even as they speak, Haven is under the influence of the Mule's power. Mis and his companions leave for Trantor to find the location of the Second Foundation and a way to defeat the Mule. As they travel, Mis becomes more and more withdrawn. In fact, in the pages leading up to their arrival on Trantor, he is only barely mentioned in the plot. When he is described, it is typically as being in a pensive mood and oblivious to events happening around him. After landing on Trantor his condition worsens considerably.