Recent human history of the Rocky Mountains is one of more rapid change. The Spanish explorer Francisco Vázquez de Coronado—with a group of soldiers, missionaries, and African slaves—marched into the Rocky Mountain region from the south in 1540. In 1610, the Spanish founded the city of Santa Fe, the oldest continuous seat of government in the United States, at the foot of the Rockies in present-day New Mexico. The introduction of the horse, metal tools, rifles, new diseases, and different cultures profoundly changed the Native American cultures. Native American populations were extirpated from most of their historical ranges by disease, warfare, habitat loss (eradication of the bison), and continued assaults on their culture.