She next traveled to and ministered in India, where she stayed for eighteen months. Smith then spent eight years in Africa, working with churches and evangelizing. She traveled to Liberia and West Africa. Smith also expanded her family by adopting two African boys. While in Africa she suffered from repeated attacks of "African Fever" but persisted in her work. As a strong proponent of the Temperance Movement both in Africa and in the United States, she was invited by noted temperance advocate Rev. Dr. Theodore Ledyard Cuyler to preach at his Lafayette Avenue Presbyterian Church in Brooklyn, New York, then the largest church in its denomination, on her return to America.