"In vitro" was among the first attempts to qualitatively and quantitatively analyze natural occurrences in the lab. Eventually, the limitation of "in vitro" experimentation was that they were not conducted in natural environments. To compensate for this problem, "in vivo" experimentation allowed testing to occur in the original organism or environment. To bridge the dichotomy of benefits associated with both methodologies, "in situ" experimentation allowed the controlled aspects of "in vitro" to become coalesced with the natural environmental compositions of "in vivo" experimentation.