"No Llores" was released as the lead single on June 18, 2007. The song received some praise by Leila Cobo of "Billboard" who called it "a standout for impeccable production and enviable mix that allows every instrumental line (and there are many) to resonate with bell-like clarity. This is real music, to be danced to as much as cherished for its adept skill". The song was a success on the Latin charts, becoming Estefan's fourteenth number-one on the "Hot Latin Songs" chart and was also another number-one on the Tropical Airplay charts. It was also a Top 20 hit in other Latin major charts such as Latin Pop Airplay, Latin Regional Mexican Airplay and Latin Rhythm Airplay charts. However, the song didn't make it onto the "Billboard" Hot 100 charting outside it at #117. To promote the song further in different formats, some remixes were made for the single, Cuban rapper Pitbull performed on a Hip-Hop version of the song, and a Reggae mix featuring Puerto-Rican Wisin & Yandel was also released. A Salsa remix was also made.