I-664 begins at a full Y interchange with I-64 and I-264 that serves as the terminus of all three Interstates in the Bowers Hill section of the city of Chesapeake. I-64 heads southeast as a continuation of the Hampton Roads Beltway through Chesapeake while I-264 heads east toward Portsmouth and Norfolk. I-664 heads west as an eight-lane freeway that has a southbound-only exit ramp to US 13 and US 460 (Military Highway) and crosses over Military Highway and a Norfolk Southern Railway rail line. The Interstate has a cloverleaf interchange with Military Highway, which here carries US 58 in addition to US 13 and US 460. The interchange also provides access to US 460 Alternate, which follows US 58 east into Portsmouth. I-664 curves north as a four-lane freeway that crosses Goose Creek and has a diamond interchange with SR 663 (Dock Landing Road) and a cloverleaf interchange with SR 337 (Portsmouth Boulevard).