The Great River Road enters Arkansas from Louisiana on US 65, which it follows to Dumas. The National Route enters the state on the Benjamin G. Humphreys Bridge (replaced by the Greenville Bridge in 2010), following US 82 to join US 65 near Lake Village. There it turns northeast on US 165, splitting onto Highway 1 in DeWitt until an intersection near Turner. The route follows a sequence of minor state highways: Highway 316 east, Highway 318 south, and Highway 20 east to Elaine, and Highway 44 northeast to Helena. It then uses short segments of Highway 20 and US 49 to reach US 49B into downtown Helena, where it leaves the state highway system, following Columbia, McDonough, and Holly Streets through a residential area. Between Helena and Bear Creek Lake, the Great River Road runs along County Road 239, a partially unpaved roadway hugging the east side of Crowley's Ridge through the St. Francis National Forest. Highway 44 begins again at Bear Creek Lake and takes the route northwest across Crowley's Ridge into Marianna, where it turns north on Poplar Street, west on Chestnut Street, and north on US 79. At Hughes, the Great River Road leaves US 79 and turns east on Highway 38, then north on Highway 147 around the north shore of Horseshoe Lake and on to US 70 at Lehi. US 70 leads east into West Memphis, where the National Route historically crossed the Memphis & Arkansas Bridge. The final leg of Arkansas's Great River Road turns north at West Memphis and uses Highway 77 and US 61 north into Missouri.