The ship operated out of Cam Ranh Bay, South Vietnam, during 1966. During the Vietnam War "Corpus Christi Bay" participated in several campaigns from 1966–1969. Last anchored off Vung Tau, the ship left for the US in late 1972, stopping at Guam, Hawaii, and going through the Panama Canal up to its home base of Corpus Christi, Texas, arriving in December, 1972. Ultimately determined by MSC to be "in excess of current and future requirements", "Corpus Christi Bay" was taken out of service in 1973 and berthed in ready reserve status at Corpus Christi, Texas.