After leaving the series, Margulies worked on stage and screen. On stage, she appeared in a MCC Theater production of Kate Robin's "Intrigue With Faye", a Lincoln Center production of Jon Robin Baitz's "Ten Unknowns", and "The Vagina Monologues." Her film work after "ER" included "Evelyn" with Pierce Brosnan and "Ghost Ship" (2002) with Gabriel Byrne and Ron Eldard. She starred as the protagonist and narrator (Morgaine) in the TNT miniseries "The Mists of Avalon" (2001) and participated in the documentary film "Searching for Debra Winger" (2002).