After his death, Masamichi's son, Kono Suemichi, and family were driven out of Hakodate into nearby Kameda during the Ainu rebellion in 1512 and little history was recorded for the area during the next 100 years. There was constant low-level conflict in the Oshima peninsula at the time with the Ainu, as armed merchants like the Kono family, established bases to control trade in the region. This conflict culminated in an uprising from 1669 to 1672, led by Ainu warrior Shakushain after which the Ainu in the region were suppressed.