Makoun made his first appearance of the 2010–11 season, starting the whole game, in a 3–2 loss against SM Caen on 15 August 2010. In a follow up match against Stade Brestois 29, he scored his first goal of the season, in a 1–0 win. Makoun then set up two goals, in a 3–1 win against Lens on 21 November 2010. However, his third season at Lyon was more even difficult for him, as he suffered a thigh injury and endured an up and down as he experiencing peaks and troughs aplenty. Even worse when he struggled to hold down a regular first-team place. Makoun spoke out, saying that he might leave the club for a fresh start. By the time Makoun departed Olympique Lyonnais, he made seventeen appearances and scoring once in all competitions.