The Browns beat the Chicago Cardinals at home in the fifth game of the season, bringing their record to four wins and one loss. Chicago scored a touchdown on their first possession, assisted by a defensive holding penalty against the Browns that gave the Cardinals a first down at Cleveland's three-yard line. A field goal by Pat Harder extended Chicago's lead to 10–0. Graham ran for a touchdown later in the first quarter after dropping back to pass near the end zone and finding room to run. Cleveland then evened the score in the second quarter with a field goal by Groza. The Cardinals scored another touchdown in the second quarter after a long drive on which the Browns were penalized for 41 yards, and led 17–10 at halftime. Chicago built on its lead six minutes into the third quarter with 36-yard passing touchdown set up by a short punt into the wind by Gillom. Graham and the Browns began to mount a comeback on the next drive with a 54-yard lateral play between Graham, Lavelli and Motley. Graham then threw a touchdown to Lavelli from 29 yards out. Another touchdown pass to Lavelli in the fourth quarter tied the game, and Cleveland took the lead for the first time with a 19-yard field goal by Groza. A touchdown run by Motley near the end of the game sealed the victory.