One central example of this is that, for opcode fetch, the Z80 combines two full clock cycles into a memory access period (the M1-signal). In the Z80 this signal lasts for a relatively larger part of the typical instruction execution time than in a design such as the 6800, 6502, or similar, where this period would typically last typically 30-40% of a clock cycle. With memory chip affordability (i.e. access times around 450-250 ns in the 1980s) typically determining the fastest possible access time, this meant that such designs were locked to a significantly longer clock cycle (i.e. lower internal clock speed) than the Z80.