On 28 March 2015, Éder made his debut for Italy, coming on as a 58th-minute substitute for Simone Zaza in a Euro 2016 qualifier against Bulgaria and scoring the equaliser in a 2–2 draw in the 84th minute. He made his first start three days later against England in a 1–1 draw in Turin, making way for fellow "oriundo" Vázquez after 61 minutes. On 10 October 2015, Éder opened the scoring in a 3–1 away win over Azerbaijan, which sealed Italy's qualification for UEFA Euro 2016. On 31 May 2016, he was named to Conte's 23-man Italy squad for Euro 2016. On 17 June, he scored the only goal against Sweden in the 88th minute during the second group game, which qualified Italy to the Round of 16; he was named "Man of the Match" by UEFA.