Putnam himself may be his own most formidable philosophical adversary: his frequent changes of mind have led him to attack his previous positions. But many significant criticisms of his views have come from other philosophers and scientists. For example, multiple realizability has been criticized on the grounds that, if it were true, research and experimentation in the neurosciences would be impossible. According to William Bechtel and Jennifer Mundale, to be able to conduct such research in the neurosciences, universal consistencies must either exist or be assumed to exist in brain structures. It is the similarity (or homology) of brain structures that allows us to generalize across species. If multiple realizability were an empirical fact, results from experiments conducted on one species of animal (or one organism) would not be meaningful when generalized to explain the behavior of another species (or organism of the same species). Jaegwon Kim, David Lewis, Robert Richardson and Patricia Churchland have also criticized metaphysical realism.