Abnormalities within the fiber bundles of the uncinate fasciculus have been linked to a host of neuropsychiatric disorders, some consistently, some inconsistently. For instance, studies of individuals with social anxiety and schizophrenia have reported changed in diffusion metrics of the uncinate. Unfortunately these findings frequently fail to replicate, the directionality of effects is mixed, and there is no specificity between findings in the uncinate and these particular diseases. An in-depth review of the clinical literature noted that “the uncinate fasciculus per se plays either a small role, or no role, in anxiety disorders “ and that “the results of DTI studies measuring changes in uncinate fractional anisotropy values in schizophrenics are contradictory.” Future researchers should focus on using superior diffusion imaging methods as well correlating specific symptoms, rather than presence or absence of disease state, with changes in white matter.