The accompanying music video, directed by Simon Brand, has a James Bond theme and features scenes of Simpson dressed as a spy. A music video for the So So Def remix was also filmed, featuring appearances by Dupri and Lil' Bow Wow inter-cut with scenes of Simpson. She performed the song as part of the set list of her DreamChaser Tour (2001) and Reality Tour (2004). The single was also promoted with live performances on various televised appearances and the MTV "Total Request Live" Tour (2001). "Irresistible" was featured on the Disney Channel Original Series "Lizzie McGuire" (2001).