Humber was assigned to start the year with the Omaha Royals of the PCL. On June 10, 2010, while pitching in a game for Omaha, Humber was hit in the face on a line drive by Luis Cruz. After lying on the mound for a few minutes, he was able to get up and walk on his own to the dugout. He was then transported to a local hospital, where he received eighteen stitches. He earned the second PCL Pitcher of the Week Award of his career for play during the week ending August 1. He won the award based on having posted a complete game 4-hit 7-strikeout shutout against the Nashville Sounds on July 30.