Ramsden's health began to fail and he traveled to Brighton on the south coast to try to benefit from its better climate, but died there on 5 November 1800. He was buried at St James's Church, Piccadilly on 13 November. His instrument-making business in London was taken over by his foreman, Matthew Berge until his death in 1819. The estate passed on to his son. Many of Ramsden's apprentices such as William Cary went on to establish their own instrument-making ventures. Others like Edward Troughton incorporated ideas from Ramsden into their own designs.