Emanuelson made his first appearance of the 2010–11 season, starting the whole game, as Ajax lost 1–0 against Twente in the Johan Cruyff Shield. He then helped the club reach the Group-Stage of the Champions League after beating PAOK Salonika and Dynamo Kiev. Shortly after, Emanuelson scored his first goal of the season, in a 5–0 win against De Graafschap. His second goal of the season came on 22 September 2010, in a 5–0 win against MVV Maastricht. Since the start of the 2010–11 season, he continued to regain his first team place, rotating in the left–back position and different midfield positions. As a result, the club began a contract negotiation with Emanuelson over a new contract, though he later stated his guarantee of not staying at the club. However, it was announced on 3 November 2010 that Emanuelson would leave Ajax at the end of the 2010–11 season. He later confirmed the news two days later. Despite announcing his departure and facing his own injury concern along the way, he remain involved in the club's first team until his departure in January. Emanuelson made thirty–two appearances and scoring two times in all competitions.