In the top of the eighth, Mueller led off with a single to right and Nixon followed with his third double of the game. Jason Isringhausen came in to pitch for the Cardinals with the bases loaded and nobody out, and was able the finish the inning without allowing a run to score. Kevin Millar pinch hit for the Red Sox starting pitcher Derek Lowe during this inning. It was the third straight game in which the Red Sox starting pitcher had not allowed an earned run.