When Shouse was an undergraduate student at Wheaton College, she convened a lecture series. It was the first Intercollegiate Vocational Conference for Women. The focus of the conference was to make jobs more accessible to women. The lecture series was held at Wheaton College and it initiated annual vocational conferences at Wheaton College until the 1950s. Shouse then proceeded to found Wheaton's first Vocational Bureau, which assisted alumnae in locating employment. In 1917, Shouse was able to utilize experience acquired through her undergraduate and her prior activist activities. She was employed by the Women's Division of the United States Employment Service of the Department of Labor. Shouse was hired as the assistant to the chief. Three years later (1920), she published her original work, "Careers for Women", which Shouse revised in 1934. Her personally signed first copy is housed in Hood College's Catherine Filene Shouse Career Center. Hood College named their career center after Shouse after her substantial contribution which enabled the college to obtain most of their modern technological equipment for worldwide career information.