Some side-channel attacks require technical knowledge of the internal operation of the system, although others such as differential power analysis are effective as black-box attacks. The rise of Web 2.0 applications and software-as-a-service has also significantly raised the possibility of side-channel attacks on the web, even when transmissions between a web browser and server are encrypted (e.g. through HTTPS or WiFi encryption), according to researchers from Microsoft Research and Indiana University. Many powerful side-channel attacks are based on statistical methods pioneered by Paul Kocher.