He was subsequently recruited to St. Louis, Missouri, to serve as director of one of the first public television stations in the country, KETC. Two years later in 1954, Guggenheim founded his film production company, Charles Guggenheim and Associates, and produced his first feature film, "The Great St. Louis Bank Robbery" (1959), starring Steve McQueen. In 1956, he produced the first political advertisement broadcast on television (for Adlai Stevenson). In the early 1960s, Guggenheim formed a partnership with television and documentary film producer Shelby Storck and he and Storck collaborated on several documentaries which were nominated for and/or won Academy Awards. Guggenheim received his first Academy Award for Documentary Short Subject for 1964's "Nine from Little Rock", about the desegregation effort in Little Rock, Arkansas in 1957. Storck and Guggenheim also collaborated on a well-received political film for Pennsylvania governor Milton Shapp in 1966. That year, Guggenheim moved his company and his family to Washington, D.C., where he became a media advisor to many Democratic political figures. He worked on four presidential campaigns and hundreds of gubernatorial and senatorial campaigns.