Edward III obtained preferment for him in the church, and from 1361 to 1368 he was employed in France in responsible positions. At an early stage in de Brantingham's career, de Brantingham served as Keeper of the Wardrobe. He was closely associated with William of Wykeham, and while the latter was in power as chancellor, Brantingham was Lord Treasurer to Edward III (from 1369 to 1371), and on two later occasions to Richard II (from 1377 to 1381; and in 1389), being appointed Bishop of Exeter on 5 March 1370 and consecrated as such on 12 May 1370. De Brantingham died in December 1394, probably on the 23rd, and was buried in the nave of Exeter cathedral.