After crossing the Hatchie River on its westernmost bridge, the Great River Road again leaves US 51 at Henning, looping west on SR 87, north on partly unpaved Crutcher Lake Road (past Fort Pillow State Park) and Four Mile Lane, and east on SR 19 to rejoin US 51 at Ripley. It leaves US 51 for the last time at Halls, following SR 88 west to near Hales Point, turning north on SR 181 atop a levee to SR 79 near Cottonwood Grove. The route continues north, slightly east of the levee, along Hoecake Road, Robison Bayou Road, Bingham Road, Mooring Road, and SR 21 into Tiptonville. The Great River Road ends its Tennessee stretch by following SR 78 to the state line.