Rai's next role was opposite Rajinikanth in the science fiction Tamil film "Enthiran" (2010), directed by S. Shankar. She was cast as Sana, a college student and the girlfriend of Rajinikanth's character. At the time of release, "Enthiran" was the most expensive Indian film production and eventually emerged as one of the highest-grossing Indian films of all time. She then appeared as Mala, an impetuous brat, in Vipul Shah's "Action Replayy"; a science fiction comedy co-starring Akshay Kumar, Aditya Roy Kapoor and Neha Dhupia.