Metrodorus was a native of Lampsacus on the Hellespont. His father's name was Athenaeus or Timocrates, his mother's Sande. Together with his brother Timocrates of Lampsacus he joined the school Epicurus had set up in their home town. Timocrates, however, soon fell out with both his brother and Epicurus and devoted the rest of his life to spreading malicious slander about them. Metrodorus on the other hand soon became the most distinguished of the disciples of Epicurus, with whom he lived on terms of the closest friendship, and whom he later followed to Athens, never having left him since he became acquainted with him, except for six months on one occasion, when he paid a visit to his home.