During the 2005 clay-court season, Safin suffered a knee injury, which he played through all the way up to Wimbledon with the help of pain killers and anti-inflammatories. Safin was subsequently defeated in the early rounds of each of the seven tournaments he played between the Australian Open and the French Open, culminating in an early round defeat at the French Open. Safin made a surprise finals appearance at the Wimbledon tune-up tournament in Halle on grass. He lost the final narrowly to the defending champion, Federer. He only played one tournament in the summer hard-court season, in Cincinnati, where he lost in the quarterfinals to Robby Ginepri. He also missed the Tennis Masters Cup.