Harlem road crosses through the business district and connects three of the hamlet's four commercial districts. Sheridan Harlem Plaza and adjacent commercial property are located at the north end of Harlem. Both Kensington Avenue and Wehrle Drive intersect the southern part of the Snyder portion of Harlem in a commercial region that extends into Cheektowaga. The Harlem–Kensington commercial district is historic. The fourth commercial district is located in the eastern edge of the hamlet at the intersection of Main Street and Kensington Avenue near the entrance to the Youngmann Expressway. The extended Snyder community has additional commercial areas along the highly commercial Sheridan Drive and on Millersport Highway.