Nyren was a nephew of the noted Slindon players Richard, John and Adam Newland who coached him as a boy. Nyren was still living at Eartham in 1758 when he married Frances Pennicud at Slindon. He had moved to Hambledon from Sussex by 1762, when he became the landlord of a pub which was then called "The Hut". Later, its name was changed to the Bat and Ball Inn; it is arguably the most famous pub with a cricketing connection and is still open for business immediately next to the Hambledon Club's ground at Broadhalfpenny Down. In 1772, Nyren took over the "more upmarket" "George Inn" which was in Hambledon village close to the church, his Hambledon colleague William Barber taking over at the "Bat and Ball" for the next 12 years. Nyren also maintained a small farm just outside Hambledon.