Human Immunodeficiency Virus (HIV), Malaria and Tuberculosis (TB) also known as “the big three” have been acknowledged as infectious diseases that disproportionately affect developing countries. Poverty and infectious diseases are causally related. Even before the time of vaccines and antibiotics, before 1796, it can be speculated that, leaders were adequately protected in their castles with decent food and standard accommodation, conversely the vast majority of people were living in modest, unsanitary homes; cohabiting with their animals. During this time people were unknowingly dying of infectious diseases in an event that; they touched their sick animals, had cuts in their skins, drank something that was not boiled or ate food that was contaminated by microbes. To exacerbate the situation, epidemics known as plagues then would emerge and wipe out the whole community. During this time, people had no knowledge on the cause of these unfavourable series of events. After speculations that their illnesses were being caused by an invisible army of tiny living beings, microorganisms, Antoni van Leeuwenhoek invented the first microscope that confirmed the existence of microorganisms that cannot be visualised with the naked eye (around the 17th century).