He starred alongside Danny Aiello and Lainie Kazan in "29th Street", a fact-based comedy/bio-pic, as the first New York State Lottery winner, Frank Pesce, Jr. This was followed by roles in the vampire/Mafia story "Innocent Blood" (1992), the comedy thriller "So I Married an Axe Murderer" (1993), the legal thriller "The Client" (1994), and the comedy "Empire Records" in 1995. That same year, LaPaglia appeared in the role of Jimmy Wyler, lead character in the TV series "Murder One", during its second and final season.