WIS 35, which hugs Wisconsin's western border, carries most of the Great River Road in that state from its entrance near East Dubuque, Illinois. The longest separation from WIS 35 is between Tennyson and a point south of Bridgeport, where WIS 35 heads inland through Lancaster and the Great River Road follows WIS 133 to Cassville, County VV and County A to Bagley, and County X and County C to return to WIS 35. The historic National Route entered Wisconsin on the Black Hawk Bridge (WIS 82), turning north on WIS 35 near De Soto. US 61 and US 53 take the route through downtown La Crosse, which WIS 35 bypasses to the east, and it follows WIS 35 Business in Holmen. Finally, at Prescott, the Great River Road turns west on US 10 across the St. Croix River on the Prescott Drawbridge into Minnesota.