Samuel de Champlain reached Lake Huron in 1615, and French missionaries began to establish posts along the Great Lakes. French settlement was hampered by their hostilities with the Iroquois, who allied themselves with the British. From 1634 to 1640, Hurons were devastated by European infectious diseases, such as measles and smallpox, to which they had no immunity. By 1700, the Iroquois had been driven out or left the area that would become Ontario and the Mississaugas of the Ojibwa had settled the north shore of Lake Ontario. The remaining Huron settled north of Quebec.