After fitting out at Philadelphia, "Berkeley" set out for her assigned homeport of Long Beach, California, mooring there on 16 March 1963 after visits to Port Royal, South Carolina; Kingston, Jamaica; and Acapulco, Mexico. Designed primarily to provide long-range anti-aircraft cover for task forces at sea, "Berkeley" devoted the next six weeks testing her Tartar anti-aircraft missile system's proficiency in that role. The warship's crew also conducted gunnery, engineering, and communication systems trials. In early May, the guided-missile destroyer demonstrated her capabilities to President John F. Kennedy, knocking down two jet drone targets with two TARTAR missiles. At the end of a short visit to the Rose Festival at Portland, Oregon, in early June, "Berkeley" entered the San Francisco Naval Shipyard for a three-month availability. At the end of the repair period, she became a unit of Destroyer Division (DesDiv) 12 and spent the rest of the year engaged in local operations in the Long Beach area.