The first settlement at Belpre was made in 1788. In 1845 railroad developers founded the Belpre and Cincinnati Railroad, but the destination was changed to Marietta, with a corresponding name change in 1851. For a considerable period of time, travelers had to go by steamboat to connect between Marietta and Parkersburg, Virginia; the latter received service from the Baltimore and Ohio Railroad in 1857. This was shortly before the western part of Virginia seceded in 1861 after the start of the American Civil War to form Unionist West Virginia. Belpre and Marietta were later connected by rail. Coal service is still active on this line.