Impressed with his winter season, the Cincinnati Reds bought his contract from the Cubs, for a reported $2,000. He made his major league debut on April 14, 1955, the same day Elston Howard became the first black man to play for the New York Yankees. Thurman hit 7 homers in only 152 at-bats, although his average fell to .217. The following year he hit .295 in only 139 chances, with 8 homers. On August 18, 1956 he hit three consecutive homers and a double against the Milwaukee Braves.