Ryan started off the 2016 season with 334 passing yards and two touchdowns in a 31–24 setback to the Tampa Bay Buccaneers. The next game, a 35–28 victory over the Oakland Raiders, he passed for 396 yards, two touchdowns, and one interception. In Week 4, Ryan threw for a team-record 503 yards and four touchdowns while teammate Julio Jones caught 12 passes for a team-record 300 yards and a touchdown in a win over the Carolina Panthers. Ryan and Jones were the first quarterback-receiver duo in NFL history to combine for at least 500 passing yards and 300 receiving yards in the same game. In October 2016, he set an NFL record for most consecutive games with at least 200 passing yards with 46 straight games. In Week 9, in the 43–28 victory over the Tampa Bay Buccaneers, he had 344 passing yards and four touchdowns to earn NFC Offensive Player of the Week. In Week 17, in a 38–32 victory over the New Orleans Saints, he had 331 passing yards and four touchdowns to earn NFC Offensive Player of the Week.