Parker Pyne is about to start a journey on a Nile steamer. The only other passengers on the vessel are Sir George and Lady Grayle, her niece Pamela, her nurse, Elsie MacNaughton and Sir George's young secretary, Basil West. Sir George married Lady Grayle to try to find a way out of his financial difficulties but the price he has paid is in having a difficult, bad-tempered, hypochondriac for a wife. Lady Grayle is annoyed that Pyne is on the boat, having been assured that her party would be the only people on board. Pamela is not sympathetic to her aunt's complaints, telling Sir George that his wife's claims of illness are fraudulent and feeling appreciative of the problems Miss MacNaughton faces in dealing with her. The only person who doesn't seem to find her too much of a trial is Basil West, who has an easy-going relationship with everyone he meets.