The Cardinals began their 2007 campaign on the road against their NFC West foe, the San Francisco 49ers. In the first quarter, Arizona trailed early as 49ers RB Frank Gore got a 6-yard TD run for the only score of the period. In the second quarter, the Cardinals took the lead with kicker Neil Rackers getting a 35-yard field goal, while RB Edgerrin James got a 7-yard TD run. San Francisco would tie the game with kicker Joe Nedney getting a 33-yard field goal.