Lattner played halfback for the University of Notre Dame under head coach Frank Leahy from 1950 to 1953. He won the Heisman Trophy in 1953, and won the Maxwell Award twice, in 1952 and 1953. In 1953, the Irish went 9–0–1, finishing second to Maryland in the final Associated Press poll. Lattner rushed for 651 yards (averaging 4.9 yards per carry) and scored nine touchdowns, caught 14 passes for 204 yards, had four interceptions and tallied two touchdowns on only 10 kickoff returns.