O'Regan worked closely with Duran Duran during the 1980s and 1990s and reunited with the reformed band for rehearsals in 2003 and European tours in 2004/2005. Having covered Pink Floyd's final tour - The Division Bell in 1994, he also shot their final ever performance at Live 8 in London's Hyde Park in 2005. His work has been exhibited at various venues including Proud Galleries, the Air Gallery, backstage at MTV's European Music Awards (London & Rome), backstage at Wembley Arena, and at Apple's flagship London Store on Regent Street. In 2016 he was the only non-US photographer featured in the Coachella 'Desert Trip' exhibition, which was attended by 100,000 visitors.