By 1520, Cocollán was an independent city under the rule of Chief Citlali (The Star). It had some tributary towns under its control like Acatlan, Villa Corona, Tizapanito, Xilotepetque and Tecolotlán. In 1521, the Spanish army under Alonso the Avalos conquered Cocollán and surrounding towns and incorporated them into the Avalos Province. A few years later, Franciscan friars persuaded the indigenous inhabitants of the city to relocate to a valley nearby, which is its present location. This is believed to have happened in 1532. There are still remains of the old city, which is referred to as Cocula Vieja (Old Cocula).