She made part of an ensemble cast in Charlie Kaufman's postmodern drama "Synecdoche, New York" (2008), alongside Philip Seymour Hoffman, Michelle Williams and Emily Watson. In the film, she portrayed Hazel, one of the women in the life of a theatre director (Hoffman) whose extreme commitment to a realistic stage production begins to blur the boundaries between fiction and reality. As her character ages from 30 to 64 over the course of the story, Morton used full-face prosthetic makeup. She discovered that she was pregnant during the filming, which had a schedule that took up to 20 hours a day. The film was a box office bomb, but garnered praise from critics, appearing on many top ten lists of the year. Morton and her co-stars were eventually nominated for the Best Ensemble Performance award at the 18th Gotham Independent Film Awards. Also in 2008, she starred in "The Daisy Chain", an Irish horror film about a couple who after the death of their daughter, take in an orphaned girl, only to become involved in a series of strange occurrences. It premiered at the 16th Raindance Film Festival (London; October 2008), and received a DVD release in 2010.