In contrast to the quiet 2009 season, 2010 saw Hughes entering several different series. His season started with a retirement at the 8 Hours of Castellet, part of the LMS, driving for Quifel-ASM in a Ginetta-Zytek GZ09S/2 alongside Amaral and Olivier Pla. The next three races Hughes contested were all part of the FIA GT1 World Championship, driving Sumo Power GT's Nissan GT-R with Jamie Campbell-Walter, with the best result of those races being a victory at the RAC Tourist Trophy, held at Silverstone. Following these three events, he returned to the Quifel-ASM team for the 24 Hours of Le Mans, alongside Amaral and Pla. For the first time since his victory in 2005, Hughes was able to finish the race, taking seventh in class and 20th overall, although the race was by no means trouble free, due to an accident and a driveshaft failure. Following this event, Hughes returned to the GT1 championship with Sumo Power GT, at the Paul Ricard round, finishing eighth. He then returned to the LMS for the 1000 km of Algarve, this time driving a DAMS-entered Oreca FLM 09 alongside Firth, and finishing sixth overall, taking the Formula Le Mans class win. His next four events were split across the LMS and the GT1 series, with both GT1 entries being for Sumo Power GT, whilst he entered one event for RLR msport (in their MG EX265) and one for DAMS, with his best overall finish out of the four races coming at the Nürburgring round, where he and Campbell-Walter finished eighth, whilst his final LMS race of the season, the 1000 km of Silverstone, saw a 14th place overall, with a class win for Hughes and Firth. Following that race, he competed in the five remaining GT1 rounds for Sumo Power GT, with third at the Navarra round proving to be his best result out of those races. At the end of the season, Hughes and Campbell-Walter were classified 12th in the GT1 championship, whilst Hughes was also classified 12th in the FLM category of the LMS.