Fifteenth Air Force was one of the two numbered air forces assigned to the Air Mobility Command. Its main area of operations was the region stretching west of the Mississippi River to the east coast of Africa, pole to pole, but was often tasked to support Air Mobility Command's global reach mission. Its primary mission was to provide strategic and theater airlift for all Department of Defense agencies as well as air refueling for the Air Force in both peace and wartime. This included the aeromedical evacuation of sick and injured.