Underway on 27 February 1981, "Berkeley" sailed to Pearl Harbor and then on to Guam, mooring there on 21 March. While en route to Subic Bay in early April, she conducted both antisubmarine and antiair warfare exercises, an underway routine that became the pattern for this deployment. The warship then joined other 7th Fleet units for a port visit to Pattaya Beach, Thailand, before participating in Exercise "Sea-Siam 81-2." "Berkeley" joined Royal Thai Navy warships in a variety of maneuvers, including tactical communications, formation keeping, and antisubmarine warfare. The guided missile destroyer then moved back to Subic Bay, after diverting for stops at Sattahip, Thailand, and Hong Kong, where she joined the "Kitty Hawk" battle group. Departing on 13 May, the group sailed into the Indian Ocean for six weeks of antiair and surface warfare exercises before putting into Geraldton, Australia, for a week-long port visit in mid-July. "Berkeley" returned to Subic Bay on 4 August for three weeks of maintenance before steaming for home on 1 September.