The guided-missile destroyer carried out local operations through April 1968 before moving into Long Beach Naval Shipyard for a maintenance overhaul. Upon completion of these repairs on 3 June, "Berkeley" loaded supplies and ammunition before steaming west on 5 July. After fuel stops at Pearl Harbor, Midway, and Guam—as well as a diversion south to avoid a typhoon near the Philippines—the warship arrived at Subic Bay on 28 July. Four days later, the guided missile cruiser departed for the coast of Vietnam and duty on "Sea Dragon" patrol. Over the next two months, "Berkeley" conducted three gunline patrols—firing nightly interdiction missions, searching for waterborne logistics craft, and bombarding supply routes—off both North Vietnam and the Vung Tau Peninsula. In between these missions, she retired to Subic Bay for upkeep. Her best hunting took place on the night of 10 and 11 September, when she and the destroyer combined to sink or damage 58 enemy supply boats.