At the beginning of 1405 The great rebellion broke out in the local population in Skadar end against the Venetian rule. The reason for it lay in the arrogant and high-handed fashion of Venetian rule, which was manifested impounding the property, which were then shared to Venetian supporters, denying the rights of Orthodox churches in the area under the supreme authority of Venice and a host of other abuses of power. In this opposition became involved Stefan's nephew Balša III (1403-1421) which sought to restore the cities which his father, Đurađ Stracimirović Balšić, once transferred to Venice (1396), to protect from the Ottoman invasion. He asked for help from Süleyman in fighting, and from Duke Vuk Lazarević, but is nevertheless a war waged without major battles and a clear winner. In the negotiations on concluding a peace as a mediator intervened and Despot Stefan himself, but they were unsuccessful, although guided by a number of occasions. He was first in May 1406 mediated by the Venetians, then in June 1407 when he was with his sister Mara and Nikita Topi supposed to guarantee that the Balša III fulfill the obligations, but peace was not concluded. A peace agreement was finally signed in June 1408th The and in it Stefan was mentioned as one of the guarantors of the signed contract, but it did not come into effect and the conflict continued.