For the season Cain was 13–11 with a 3.14 ERA, 177 strikeouts, and 61 walks. He finished sixth in the league with a 1.08 WHIP and innings pitched. He tied for third with four complete games (tied with Ubaldo Jiménez and Johan Santana behind Roy Halladay's nine and Wainwright's five), including two shutouts (which made him one of seven players in the NL to throw two or more shutouts). He tied for 12th in NL Cy Young Award voting with Bronson Arroyo.