The Mark & Brian Show was an American radio talk show hosted by Mark Thompson and Brian Phelps, known on the air as "Mark & Brian." The syndicated program aired weekday mornings from KLOS-FM in Los Angeles, California, and blended comedy sketches, listener phone calls, interviews with in-studio guests, and the occasional road trip. At the peak of its popularity, the show was syndicated to 21 other markets in the western US, including San Francisco, Honolulu, Portland Oregon, and Tucson Arizona.