In Week 1 against the Minnesota Vikings, Ryan completed 33-of-46 passes for 304 yards, two passing touchdowns, and two interceptions in the 28–12 loss. In Week 2 against the Philadelphia Eagles, Ryan threw for 320 yards, three touchdowns, and three interceptions as the Falcons won 24–20. On fourth down with two minutes left in the game, Ryan threw a 54-yard touchdown pass to Julio Jones that ended giving the Falcons the late go-ahead score. In Week 3 against the Indianapolis Colts, Ryan threw for 304 yards, three touchdowns, and one interception as the Falcons lost 27–24. In Week 4, in a 24–10 loss to the Tennessee Titans, Ryan passed for 397 yards. In Week 5 against the Houston Texans, Ryan threw for 330 yards, three passing touchdowns, and one interception while adding a rushing touchdown in the 53–32 loss. Ryan became the first Falcon quarterback since Chris Miller in 1990 to pass for over 300 yards and have three passing touchdowns and a rushing touchdown in the same game. In Week 6 against the Arizona Cardinals, he passed for 356 yards and four touchdowns in a 34–33 loss. In Week 7 against the Los Angeles Rams, Ryan threw for 159 yards and an interception before suffering an ankle injury. Without Ryan, the Falcons lost 37–10.