The province of Medio Campidano (; ) was a province in the autonomous region of Sardinia, Italy. As of 2015, the province had a population of 100,141 inhabitants over an area of , giving it a population density of 66 inhabitants per square kilometre. It had two chief towns, Villacidro and Sanluri, with 14,245 and 8,543 inhabitants, respectively. It was established in 2005 from a section of the province of Cagliari. It contained 28 "comuni" (singular: "comune") and the president of the province was Fulvio Tocco.