OSHA defines hazard determination as "the process of evaluating available scientific evidence in order to determine if a chemical is hazardous pursuant to the HCS." While chemical manufacturers and importers are required to conduct a hazard determination, other companies may voluntarily conduct a hazard determination to ensure worker health and safety. Under the hazard determination framework, any chemical that has a physical or health hazard is considered a hazardous chemical. Physical hazards include fire hazards, reactive hazards, and explosion hazards. Heath hazards include systemic effects and target organ effects. Chloroprene is on OSHA's list for substances that are regulated as toxic and hazardous.