In 2005, Chambers started all 16 games in which he played. He led Miami with 82 receptions for 1,118 yards and 11 touchdowns - figures which earned him his first Pro Bowl selection. His reception total tied for sixth in the AFC and 13th in the NFL, while his yardage figure was third in the conference and 12th in the league. His eleven touchdown catches tied for the second-highest figure in the conference and third in the NFL, trailing only Indianapolis' Marvin Harrison (12) and Carolina's Steve Smith (12). Chambers set career highs for both receptions and receiving yards, while his touchdown total equaled his career best from 2003. Over the final six games of the season, he recorded 43 catches for 620 yards and six touchdowns. With 82 catches on the year, Chambers became the first wide receiver to increase his receiving totals in each of his first five NFL seasons since Muhsin Muhammad did it from 1996–2000 with the Carolina Panthers. In addition, Chambers became just the second Dolphins wide receiver to do it, joining O.J. McDuffie (1993–1997). He became the first Dolphin to record 1,000 or more receiving yards since Tony Martin had 1,037 receiving yards in 1999. Overall, it marked the 14th time a Dolphin had a 1,000 receiving yard season, and he is the sixth different Dolphin player to reach that plateau, joining Mark Clayton (five times), Mark Duper (four), Irving Fryar (two), O.J. McDuffie (one) and Tony Martin (one). Chambers also rushed for 92 yards on 12 attempts during the course of the season, good for third on the team in rushing.