Tullamore lies on the N52 national secondary road. This connects to Birr in the southwest of the county and continues towards Mullingar which is located to the northeast. At Kilbeggan (about 12 km north of Tullamore) the N52 forms an interchange with the M6 motorway which connects Dublin and Galway. The N80 national secondary road connects Tullamore with Killeigh, Mountmellick and Portlaoise, travelling in a southwards direction. A number of Regional roads run through the town such as the R420 connecting Tullamore to Moate, Clara and Portarlington, and the R421 which connects to Kinnitty.