State Route 160 begins in eastern Antioch at SR 4. After two interchanges, the highway rises onto the two lane Antioch Bridge over the San Joaquin River. It cuts north across the center of Sherman Island, reaching the Sacramento River on the opposite shore. From here to Sacramento, SR 160 never strays far from the river, first following the east levee over the 1949 Three Mile Slough Bridge (a lift bridge), past Brannan Island State Recreation Area, and across SR 12 opposite the river from Rio Vista. After passing Isleton, the highway crosses the river on the Isleton Bridge, a bascule bridge built in 1923, and runs along the west shore on Grand Island, where it meets the east end of SR 220. The Walnut Grove Bridge carries County Route J11 east across the river to Walnut Grove, and, at the north end of the island, SR 160 crosses the 1924 Steamboat Slough Bridge onto Sutter Island and then the 1923 Paintersville Bridge across the Sacramento River to the mainland, both bascule bridges.