At age three, Anna fell and suffered a fracture of her femur. She fell again at age five and suffered osteomyelitis with purulent knee arthritis. These problems handicapped her, and her mother went to extraordinary lengths to find a remedy by taking Anna and three of her siblings to Berlin for treatment by Dr. Bernhard von Langenbeck. The treatment lasted 18 months and included thermal baths at Kreuznach. Unfortunately, it was not successful, and Anna remained hobbled all her life. While they were in Europe, her mother ensured that her children received excellent tutoring. The time away in Europe strained the Klumpkes' relationship. When Anna was fifteen, her parents divorced. She and her siblings (now numbering five) moved with their mother to Göttingen, Germany, where they lived for a time with Mattilda's sister, who had married a German national. Anna and her sister Augusta were sent to school at Cannstatt, near Stuttgart. When she was seventeen, the family moved to Clarens, near Lake Geneva in Switzerland where she spent two years in a boarding school.