80% of clinical cases of pseudoxanthoma elasticum have detectable mutations in the "ABCC6" gene. Mutations in almost all parts of the gene have been described, of all types (missense, nonsense, splice alteration, insertion, small deletion or large deletion). Although there have been reports of autosomal dominant inheritance, the inheritance is typically autosomal recessive (both parents need to be carriers, and there is a 25% chance that a child will inherit "both" abnormal copies of the gene and therefore develop the condition).