"Call Me When You're Sober" achieved commercial success in the US. For the week ending September 2, 2006, the song debuted at numbers 25 and 11 on the US "Billboard" Hot 100 and on the Hot Digital Songs chart respectively. The following week, it moved to its peak position of number ten on the former chart, being the greatest sell gainer for that chart issue. With this feat, the song became the band's third top ten single on that chart; it further remained on the "Billboard" Hot 100 for a total of twenty two weeks, last seen at number 35. Furthermore, the single peaked in the top ten of several other "Billboard" charts in the US; on the Adult Pop Songs chart it attained the position of six for the week ending of November 11, 2006 and on the Mainstream Top 40 it peaked at number seven for the week ending November 25, 2006. It additionally peaked at numbers four and five on the "Billboard" Hot Modern Rock Tracks and the "Billboard" Hot Mainstream Rock Tracks charts respectively. The single managed to rank at number 77 on the Hot 100 year-end chart for 2006. It was certified platinum by the Recording Industry Association of America (RIAA) on February 17, 2009, for selling more than 1,000,000 copies in that country.