"Spruance" deployed for a six-month period in January 1983 to the Persian Gulf where she spent four and one-half months conducting observations in company with during the Iraq-Iran War. She also conducted operations with Teamwork '84 in the northern Atlantic and in the Arctic Ocean in 1984. She deployed to the Mediterranean Sea in November 1984 and conducted her second Black Sea Operations over Thanksgiving 1984. She returned from her deployment in May 1985 and shortly thereafter entered her second overhaul period during which she received VLS, Towed Array, and the SH 60. She deployed for a six-month period on 26 May 1993 to the Red Sea where she spent over three and a half months conducting visit and board and search operations in support of United Nations sanctions against Iraq. While attached to the U.S. Sixth Fleet, "Spruance" conducted a brief stop for fuel in Rota, Spain, followed by a liberty port visit in Palma, Spain. Additional stops in the Mediterranean consisted of a brief stop in Augusta Bay, Sicily, then to Souda Bay, Crete, for a maintenance period (IMAV) with . "Spruance" passed through the Suez Canal on 29 June.