Upon her father's death in 2000, she inherited majority control and became chair of Hensley & Co., one of the largest Anheuser-Busch beer distributors in the United States. She participated in both of her husband's presidential campaigns and, in 2008, drew both positive and negative scrutiny for her appearance, demeanor, wealth, spending habits, and financial obligations. She continues to be an active philanthropist and serves on the boards of Operation Smile, Eastern Congo Initiative, CARE, and HALO Trust, frequently making overseas trips in conjunction with their activities. During the 2010s, she has become prominent in the fight against human trafficking. From 2017 until his death the following year, she dealt with her husband's battle against glioblastoma. She has remained visible in public life since then.