In 1995, Hopper played a greedy TV self-help guru, Dr. Luther Waxling in "Search and Destroy". The same year, he starred as Deacon, the one-eyed nemesis of Kevin Costner in "Waterworld". And in 1996 he starred in the science fiction comedy "Space Truckers" directed by Stuart Gordon. In 1999, he starred in The Prophet's Game (a dark thriller), Directed by David Worth and also starring Stephanie Zimbalist, Robert Yocum, Sandra Locke, Joe Penny and Tracey Birdsall. In 2003, Hopper was in the running for the dual lead in the indie horror drama "Firecracker", but was ousted at the last minute in favor of Mike Patton. In 2005, Hopper played Paul Kaufman in George A. Romero's "Land of the Dead". In 2008, Hopper starred in "An American Carol". In 2008 he also played The Death in Wim Wenders' "Palermo Shooting". His last major feature film appearance was in the 2008 film "Elegy" with Ben Kingsley, Penélope Cruz and Debbie Harry. For his last performance, he was the voice of Tony, the alpha-male of the Eastern wolf pack inside the 2010 3D computer animated film "Alpha and Omega". He died before the movie was released. This brought the directors to dedicate the film to his memory at the beginning of the movie credits.