The project was problematic, however, and Madame Guyon clashed with the sisters who were in charge of the house. The Bishop of Geneva sent Father La Combe to intervene. At this point, Guyon introduced La Combe to a mysticism of interiority. While her daughter was in an Ursuline convent in Thonon as a pensioner, Madame Guyon continued in Gex, experiencing illness and great difficulties, including opposition from her family. She gave over guardianship of her two sons to her mother-in-law and took leave of her personal possessions, although keeping a sizeable annuity for herself.