In carpal tunnel syndrome, one of the tendons or tissues in the carpal tunnel is inflamed, swollen, or fibrotic and puts pressure on the other structures in the tunnel, including the median nerve. Carpal tunnel syndrome is the most commonly reported nerve entrapment syndrome. Carpal tunnel syndrome is often associated with repetitive motions of the wrist and fingers; jobs like typists, pianists, and meat cutters are at particularly high risk. The tough flexor retinaculum along with the rest of the carpal tunnel cannot expand, putting pressure on the median nerve running through the carpal tunnel with the flexor tendons of the wrist. This results in the symptoms of carpal tunnel syndrome.