Koyré focused on Galileo, Plato and Isaac Newton. His most famous work is "From the Closed World to the Infinite Universe", a series of lectures given at The Johns Hopkins University in 1959 on the rise of early modern science and the change of scientists' perception of the world during the period from Nicholas of Cusa and Giordano Bruno through Newton. Though the book has been widely heralded, it was a summation of Koyré's perspective rather than an original new work.