Metrodorus died in 278/7 BC, in the 53rd year of his age, seven years before Epicurus, who would have appointed him his successor had he survived him. He left behind him a son named Epicurus, and a daughter, whom Epicurus, in his will, entrusted to the guardianship of Amynomachus and Timocrates of Potamus, to be brought up under the joint care of themselves and Hermarchus, and provided for out of the property which he left behind him. In a letter also which he wrote upon his death-bed, Epicurus commended the children to the care of Idomeneus, who had married Batis, the sister of Metrodorus. The 20th of each month was kept by the disciples of Epicurus as a festive day in honour of their master and Metrodorus. Leontion is spoken of as the wife or mistress of Metrodorus.