Querrey's next tournament was the 2010 Regions Morgan Keegan Championships, where he was seeded eighth. He defeated defending champion Roddick in the quarterfinals. He then defeated Ernests Gulbis in the semifinals, and defeated fellow American John Isner, for the championship. Querrey also teamed with Isner in the doubles, where they won the championship; Querrey became the first player to win the singles and doubles at Memphis simultaneously since 1981. At the Abierto Mexicano Telcel, he lost in the first round against Fernando González in three sets.