The Falcons finished the regular season 13–3, with the first seed in the NFC. Ryan, who was 0–3 in the postseason coming into the playoffs, won his first postseason game in the against the Seattle Seahawks, with Ryan orchestrating the final scoring drive that led to Matt Bryant's game-winning 49-yard field goal. Ryan finished with 250 passing yards, 68.6% completion percentage, three touchdowns, and two interceptions in the 30–28 victory. In the against the San Francisco 49ers, Ryan threw for 396 yards and three touchdowns, but also committed two turnovers in crucial portions of the game, and later sprained the AC joint to his non-throwing shoulder as the Falcons lost 28–24. He did not require surgical procedure to repair his shoulder and would have been able to play in Super Bowl XLVII if the Falcons had advanced. He was named to the Pro Bowl for the second time in his career, but he declined due to the shoulder injury. He was ranked #17 by his fellow players on the NFL Top 100 Players of 2013.