On August 28, 2006, the Devil Rays called Young up to the major leagues after it was decided that Jonny Gomes had to undergo season-ending surgery. His first game at the Major League level was against the Chicago White Sox and occurred on August 29, 2006, ten years to the day his older brother Dmitri played in his first major league game. In Delmon's first major league plate appearance, White Sox pitcher Freddy García hit Young with a first-pitch fastball. After striking out in his first official at-bat, Young stroked a curveball for a two-run home run, which was his first Major League hit.