Wilkes-Barre ( or ) is a city in the U.S. state of Pennsylvania and the county seat of Luzerne County. Located at the center of the Wyoming Valley, it had an estimated population of 40,766 in 2019. It is the second-largest city (after Scranton) of the Scranton–Wilkes-Barre–Hazleton, PA Metropolitan Statistical Area, which had a population of 563,631 as of the 2010 Census and is the fourth-largest metropolitan area in Pennsylvania. Wilkes-Barre and the surrounding Wyoming Valley are framed by the Pocono Mountains to the east, the Endless Mountains to the north and west, and the Lehigh Valley to the south. The Susquehanna River flows through the center of the valley and defines the northwestern border of the city.