The work of modern physicists designed to discover the theory of everything (TOE) is reaching deep into the microcosm under the assumption that the macrocosm is eventually made of the microcosm. This approach falls short on two counts: the first is that the fundamental is not the same as significant; secondly, this approach does not take into account that the microcosmic dimension is open ended. It follows that the search for TOE will discover phenomena more microcosmic than strings or the more comprehensive M theory. It is also the case that many laws of nature that apply to systems relatively low in the hierarchy cease to apply at higher levels. M theory might have predictive power at the sub-atomic level but it will inform but little about reality at higher levels. The work of the particle physicists is indeed laudable but possibly they should give the theory they are looking for another name. This is not to claim that the concept of holarchy is already the theory of everything.