In the early 17th century, Tyszowce was raided by Tatars, and in 1649, the town was destroyed during the Khmelnytsky Uprising. Further destruction took place in the 1650s, when Tyszowce was ransacked by Cossacks, Russians and Tatars. On December 29, 1655, the Tyszowce Confederation was signed here, with the purpose of pushing Swedes out of Poland, and bringing back King Jan Kazimierz Waza. The document was signed by Hetmans Stanislaw Potocki and Stanislaw Lanckoronski, as well as several senators, military leaders and members of nobility.