During his first season with Schalke, Reginiussen's efforts to secure a place on the team were severely hampered by injury. He made his Bundesliga debut against Hoffenheim on 30 January; he came on as a substitute, receiving 19 minutes of playing time on the right back. The following day, he was injured during a practice session, resulting in back pains that had him sidelined for several weeks. Once free of his injury, he spent the remainder of the season playing for the reserve team. During in which, Regininussen kept three clean sheets in a row between 13 April 2010 and 24 April 2010. In May, Reginiussen admitted that, with Schalke's qualification for the Champions League, and the signing of Christoph Metzelder, yet another centre back, his chances of gaining first team appearances in the coming season were looking slim. He also confessed that Schalke willing, he might consider being loaned out to another club.