Osmosis Jones is a 2001 American live-action/animated buddy cop comedy film directed by the Farrelly brothers with animated scenes directed by Piet Kroon and Tom Sito. Starring the voices of Chris Rock, Laurence Fishburne, David Hyde Pierce, Brandy Norwood and William Shatner alongside live actors Bill Murray, Molly Shannon and Chris Elliott, the film centers on Frank DeTorre (Murray), a slovenly zookeeper; the live-action scenes are set outside Frank's body while the animated scenes are set inside his body, which is portrayed as a city inhabited by anthropomorphic parameciums. In the animated sequences, white blood cell cop Osmosis "Ozzy" Jones and cold pill Drix attempt to prevent deadly virus Thrax from killing Frank within forty-eight hours.