Departing Long Beach on 13 February, the guided-missile destroyer made fuel stops at Pearl Harbor, Midway, and Guam before arriving at Yokosuka on 4 March. After two weeks of upkeep, she sailed to "Yankee Station"—arriving there on 23 March—and provided planeguard support for "Constellation" and . Then, starting on 10 May, the warship provided two weeks of naval gunfire support off South Vietnam. Between 25 May and 15 June, "Berkeley" visited Hong Kong and Kobe for rest and recreation before returning to South Vietnam for four weeks of gunline operations. Next came a port visit to Bangkok, Thailand, in mid-July, followed by three days of upkeep at Subic Bay. From there, the warship sailed for home on the 27th and moored at Long Beach on 14 August. The remainder of the year was dedicated to type training and upkeep in preparation for another western Pacific deployment in early 1971.