At least one fatal instance of intraspecific combat among "Tylosaurus" is documented. This can be seen in the "T. kansasensis" holotype FHSM VP-2295, representing a long animal, which possesses numerous injuries that indicate it was killed by a larger "Tylosaurus". The skull roof and surrounding areas exhibit signs of trauma in the form of four massive gouges, and the dentary contains at least seven puncture wounds and gouges. These pathologies are unequivocally characteristic of bite marks from a larger "Tylosaurus" that measured around in length. The largest of the marks are about in length, matching the size of large mosasaur teeth, and they are positioned along two lines that converge close to 30°, matching the angle that each jaw converges towards in a mosasaur skull. In addition, FHSM VP-2295 suffered damage to the sclerotic ring, a detached quadrate, and an articulation of the cervical vertebrae at an unnatural angle of 40° to the skull's long axis. The pattern of preservation makes it unlikely that the condition of the vertebrae was a result of disturbances by scavengers and instead indicates damage caused by a violently twisted neck during life. In a reconstructed scenario, the larger "Tylosaurus" would have first attacked at an angle slightly below the left side of the vicitim's head. This impact would cause the victim's skull to roll to the right side, allowing the aggressor to sink its teeth into the skull roof and right lower jaw, the latter leading to the collapse of the jawbone, further breaks of nearby bones such as the pterygoid, a break in the right eye, and the twisting of the jawbone outwards. This would subsequently cause the quadrate to detach from its position and the spinal cord to twist and sever at the skull's base, leading to a swift death.