Growing up in a predominantly African American and Hispanic neighborhood, Leland attended Wheatley High School in Houston, Texas, where he ranked in the top ten percent of his class when he graduated from Wheatley in 1964. While attending Texas Southern University in the late 1960s, he emerged as a vocal leader of the Houston-area civil rights movement and had brought national leaders of the movement to Houston. Leland graduated from Texas Southern in 1970 with a Bachelor's degree in Pharmacy. He served as an Instructor of Clinical Pharmacy at his alma mater in 1970–71, where he set up "door-to-door" outreach campaigns in low-income neighborhoods to inform people about their medical care options and performing preliminary screenings.