"Euphorbia tithymaloides" was introduced as a garden plant prior to 1688. The first record of it growing in a garden was in Amsterdam. It is primarily used as an outdoor garden border plant, but certain varieties do well indoors. Because of the plant's toxicity, gardeners are cautioned to wear goggles, gloves, long-sleeved shirts, and long pants. Propagation may be by seed or cutting. Cuttings should be made above a joint, be long, and planted in sandy, nutrient-rich soil and allowed to root before planting. Cuttings should be made in March – April or June – July, and from the middle or top of the main stem.