In 1989, Campbell costarred in the crime film "Rooftops", and the following year starred alongside Eddie Murphy in the action comedy "Another 48 Hrs.". She later appeared in an supporting role in the 1992 romantic comedy "Boomerang" starring Murphy. Her most notable film credit is 1990 comedy "House Party" for which she received Independent Spirit Award for Best Supporting Female nomination. She later co starred in its two sequels; "House Party 2" (1991), and "House Party 3" (1994). In 1997, she received her star billed role in the Trimark Pictures' comedy film "Sprung". She later had the leading role in the independent drama film "The Last Place on Earth" (2002), and has appeared in sex comedy film "Zack and Miri Make a Porno" (2008) playing Craig Robinson's character wife.