As a child, Watkins was diagnosed with sickle cell anemia. Since the age of seven, she has been in and out of the hospital due to the painful condition. T-Boz opened up to the public about the disease in 1996; she later became one of the spokespersons for Sickle Cell Disease Association of America. In 2002, she was hospitalized for four months due to a flare-up of sickle-cell anemia. She is a national co-chair of the progressive organization Health Care Voter.