Wyatt Earp, a retired peace officer with a notable reputation, reunites with his brothers Virgil and Morgan in Tucson, Arizona, where they venture on toward Tombstone to settle down. There they encounter Wyatt's long-time friend Doc Holliday, who is seeking relief in the dry climate from his worsening tuberculosis. Josephine Marcus and Mr. Fabian are also newly arrived with a traveling theater troupe. Meanwhile, Wyatt's common-law wife, Mattie Blaylock, is becoming dependent on laudanum. Wyatt and his brothers begin to profit from a stake in a gambling emporium and saloon when they have their first encounter with the Cowboys.