The 380th Bombardment Group remained inactive from 20 February 1946 until its redesignation from Heavy to Very Heavy on 13 May 1947. On 29 May 1947, the Group was activated at MacDill Field, Florida, as a Boeing B-29 Superfortress reserve unit under the 49th Bombardment Wing. The group remained an inactive reserve unit until being called to active duty on 1 May 1951 during the Korean War. Fifteen days later on 16 May 1951, after the personnel had been processed for active duty and transferred to other units, the Group was inactivated.