Vane was recognised by his political peers as a competent administrator and a wily and persuasive negotiator and politician. His politics was driven by a desire for religious tolerance in an era when governments were used to establish official churches and suppress dissenting views. Although his views were in a small minority, he was able to successfully build coalitions to advance his agenda. His actions contributed to both the rise and downfall of the English Commonwealth. His books and pamphlets written on political and religious subjects are still analysed today. His writing "A Healing Question" advocated for a constitutional convention pre-dating the American Constitutional Convention by over a century. Vane is remembered in Massachusetts and Rhode Island as an early champion of freedom.