The National Route reenters from Muscatine, following IL 92 east through the Quad Cities except for a detour onto County Road TT east of Illinois City. On the East Moline-Silvis border, the Great River Road turns back north along IL 84, which stays near the river most of the way to a point southeast of Galena. US 20 carries the route through Galena to East Dubuque, where the National Route crosses the river one last time into Dubuque, Iowa on the Julien Dubuque Bridge. No route is signed on the Illinois side of the Mississippi north of East Dubuque, although Wisconsin Highway 35 has Great River Road markers all the way to the state line (at IL 35).