For six years she hosted her own show on HLN, "Jane Velez-Mitchell" (formerly known as Issues with Jane Velez-Mitchell) replacing Glenn Beck, who moved to Fox News Channel. She is often seen commenting on high-profile cases for CNN, TruTV, E! and other national cable TV shows. Velez-Mitchell frequently guest hosts for Nancy Grace on her Headline News show. Velez-Mitchell reported for the nationally syndicated show "Celebrity Justice" (produced by corporate sibling Telepictures). She also appears as a substitute host on HLN's "Showbiz Tonight". In October 2014, HLN's "Jane Velez-Mitchell" show was cancelled.