Chen was the moderator and co-host of the CBS Daytime talk show, "The Talk", which premiered on October 18, 2010. The show featured Chen, the show creator Sara Gilbert, Sharon Osbourne, Leah Remini, Holly Robinson Peete and Marissa Jaret Winokur. On September 18, 2018, Chen announced in a prerecorded tape that she would not be returning to "The Talk" because she needed "to spend more time at home with husband", after a number of sexual assault allegations surfaced against her husband Les Moonves.