The highway crosses the Catawba River as it enters Mecklenburg County, then interchanges with I-485 as it passes north of Charlotte-Douglas International Airport. After crossing I-485, it turns northeastward again, bypassing Uptown Charlotte to the west and north. While the route does not enter Uptown, several exits do provide access to the area. An interchange with Interstate 77 north of Uptown provides direct freeway access. The route through Charlotte traverses the northern portion of the city and is more suburban than urban in character, with light industry such as truck terminals, warehouses, small manufacturing facilities, and small office parks lining the highway. It also passes by the University City area and the University of North Carolina at Charlotte.