Vane was also active in domestic affairs. He sat on a committee that disposed of Charles I's art collection, and made many enemies in his role on the committees for Compounding and Sequestration. These committees, on which Vane had also sat in the 1640s, were responsible for the distribution of assets seized from royalists and other government opponents, and for negotiating with those who had failed to pay taxes and other government charges. Some of the enemies he made while engaged in this work would one day sit in judgment against him.