A number of national and regionally noted blues musicians are from Leland. There are five Mississippi Blues Trail markers in Leland commemorating the small town's significant contribution to blues history. Highway 61, mentioned in numerous blues recordings, runs through the town and gives its name to the community's blues museum. Leland is the burial place of the folk artist and blues musician James "Son" Thomas, who lived for many years near the railroad tracks. Thomas is buried beneath a gravestone donated by Mt. Zion Memorial Fund, to which musician John Fogerty of Creedence Clearwater Revival was a yearly contributor.