Ryan's 2010 season started off slow in a 15–9 loss to the Pittsburgh Steelers. He was 27-of-44 for 252 yards and an interception. He bounced back in the next game against the Arizona Cardinals. In the 41–7 victory, he was 21-of-32 for 225 yards and three touchdowns. In Week 7, he had his most efficient game of the season in the 39–32 win over the Cincinnati Bengals. He was 24-of-33 for 299 yards, three touchdowns, and one interception for a season-high 118.1 passer rating. The victory over the Bengals was the start of an eight-game winning streak for Ryan and the Falcons. In Week 10, against the Baltimore Ravens, he passed for 316 yards and three touchdowns in the 26–21 win. After falling to the New Orleans Saints in Week 16, Ryan closed out the regular season with a 31–10 victory over the Carolina Panthers with 236 passing yards and two touchdowns.