Trot Nixon extended the Red Sox lead to two in the top of the fourth, hitting a single to right field that scored Mueller, who had started the rally with a two-out double to left-center. Johnny Damon then led off the Red Sox's fifth inning with a double to right. Singles by Orlando Cabrera and Ramírez, to right and left respectively, scored Damon to make it 3–0. With two out, Mueller singled along the first base line, enabling Cabrera to score the Red Sox's fourth run. Suppan was replaced by Al Reyes, which meant none of the Cardinals three starting pitchers had finished five innings during the series.