A longtime charity supporter, in 2012 O'Regan collaborated with Damien Hirst on a U2 print for Cancer Research UK which raised £50,000 in 10 minutes, thanks to auctioneer Al Murray. He has held numerous events in aid of Rainbow Trust Children's Charity where guests such as Boy George, Peter Frampton and Tony Hadley performed acoustically, and donates a print every year to the Ace Africa charity. His limited edition Duran Duran book "Careless Memories" was published in 2015, and he continues to work closely with Italian legend Gianni Nannini and longtime friends Europe.