The station was opened by the Royston and Hitchin Railway in October 1850 as its initial eastern terminus. The line was subsequently extended as far as the following year and through to Cambridge by the Eastern Counties Railway in 1852. The latter company took out a lease on the Royston company from then until 1866 and ran trains between Cambridge and the Great Northern Railway's main line junction at Hitchin until its lease expired. Thereafter the GNR took over and began running through trains from Cambridge to Kings Cross from 1 April 1866.