"Kiss Kiss" debuted at number 100 on the US "Billboard" Hot 100 in the issue dated September 29, 2007. In the song's sixth week on the chart, it ascended to number two, rising from number 22, following a surge in digital downloads, totaling 159,000 for that week. One week later, in the issue dated November 10, 2007, "Kiss Kiss" topped the "Billboard" Hot 100 while earning the biggest airplay and digital sales gainer and ending the seven-week streak held by Soulja Boy's "Crank That (Soulja Boy)". The song remained atop the Hot 100 for three consecutive weeks and earned the airplay gainer title during that period. The song also peaked at number two on the US Radio Songs and at number four on the US Pop Songs charts. As of April 2014, the single has sold 3,117,000 copies in the US. On August 23, 2019, the single was certified quadruple platinum by the Recording Industry Association of America (RIAA) for sales of over four million copies in the United States.