Barry was a successful comedian who created a variety of Restoration comedy heroines throughout her career, but her greatest impact on Restoration drama was as a tragic actress. Her capacity for projecting pathos was an inspiration to playwrights Thomas Otway and Thomas Southerne in the three famous tragic roles they wrote for her: Monimia in Otway's "The Orphan" (1680), Belvidera in Otway's "Venice Preserved" (1682), and Isabella in Southerne's "The Fatal Marriage" (1694). These three roles, wrote the prompter John Downes, "gain'd her the Name of Famous Mrs. Barry, both at Court and City, for whenever She Acted any of these three Parts, she forc'd Tears from the Eyes of her Auditory, especially those who have any Sense of Pity for the Distress't."