Orgelbrand is credited with publishing at least 300 titles and perhaps as many as 600 titles (according to a different count, over 250 titles in 520 volumes); most in the Polish language but about 100 in Hebrew, such as the Mishna, Gemara, Pentateuch and prayer books. He also published several books in Yiddish, such as an edition of "Tseno Ureno". One of his most notable Hebrew titles was a 20-volume Babylonian Talmud (1859–1864). It was the commercial success of the Talmud title, of which 12,000 copies were sold, that allowed him to underwrite the costly encyclopedia project. He reaped significant profits by publishing Jewish titles in Congress Poland, which had fewer restrictions than the Russian Empire yet maintained favorable trade agreements with the latter.