Between 2012 and 2019 Spike was Assistant Director and Chief Curator of the Muscarelle Museum of Art at The College of William & Mary, in Williamsburg, Virginia. During his tenure, Spike curated and authored the catalogues for several international loan exhibitions of Italian art including "Michelangelo: Sacred and Profane, Masterpiece Drawings from the Casa Buonarroti and A Brush with Passion: Mattia Preti (1613-1699)" as part of the “2013 Year of Italian Culture” in the United States in cooperation with the Italian foreign ministry; "Caravaggio Connoisseurship: Saint Francis in Meditation and the Capitoline Fortune Teller" in 2014; "Leonardo da Vinci and the Idea of Beauty" in 2015; and "Botticelli and the Search for the Divine: Florentine Painting between the Medici and the Bonfire of the Vanities", with Alessandro Cecchi, in 2017. These exhibitions were under the auspices of the Italian Embassy in Washington, D.C. Michelangelo: Sacred and Profane, Masterpiece Drawings from the Casa Buonarroti; Leonardo da Vinci and the Idea of Beauty; and Botticelli and the Search for the Divine were also exhibited at the Museum of Fine Arts, Boston, MA. Additionally, the Leonardo exhibition under the title "Leonardo da Vinci y la Idea de la Belleza" drew record crowds during its exhibition at the Palacio Real, Ciudad de Mexico in 2015.