Sansone began modeling when he was still a teenager. During the Depression, Sansone profited by selling pictures of himself through mail-order ads. He became a much sought-after model who posed for paintings, photographs, and sculpture. He was featured on many magazine covers, both American and European. He modeled for statues by James Earle Fraser ("Meriwether Lewis;" Fraser also designed the US buffalo nickel), Arthur Lee ("Rhythm" which was created over five years, 1925–1930), and Malvina Hoffman ("Nordic Type" and "Elemental Man").