Hieronymus Cock was born into an artistic family. His father Jan Wellens de Cock and his brother Matthys Cock were both painters and draftsmen. He was admitted as a master painter in the Guild of Saint Luke in Antwerp in 1545. He resided in Rome from 1546 to 1547. When he returned to Antwerp in 1547, he married Volcxken Diericx. Together with his wife he founded in 1548 the publishing house "Aux quatre vents" or "In de Vier Winden" (the "House of the Four Winds"). The publishing house issued its first prints in 1548. The majority of Cock's prints were made after paintings or designs purposely made for him by artists from the Low Countries such as Frans Floris, Pieter Brueghel the Elder, Lambert Lombard, Maarten van Heemskerck and Hieronymus Bosch as well as architectural and ornament designs by Cornelis Floris and Hans Vredeman de Vries.