On 21 May, "Nizam" participated in the shelling of Scarpanto, then became involved in the Battle of Crete. The destroyer transported commandos from Alexandria to Suda Bay, and returned with wounded. When the campaign turned for the worse, "Nizam" and made two evacuation runs to ferry troops from the island to Alexandria. Following the unsuccessful campaign, "Nizam" was assigned to the Syria-Lebanon Campaign for three weeks, then retasked to the Tobruk Ferry Service, a force of British and Australian warships making supply runs to the Allied forces under siege in Tobruk. "Nizam" made fourteen runs before receiving damage on 14 September; a near-miss from a bomb cracked oil pumps, and the destroyer was towed away from the area by the destroyer , then was able to make temporary repairs and reach Alexandria.