On Rotten Tomatoes, the film has an approval rating of 55% based on 108 reviews, with an average rating of 5.5/10. The site's critical consensus reads, "The animated portion of "Osmosis" is zippy and fun, but the live-action portion is lethargic." At Metacritic, which assigns a weighted average rating to reviews, the film has received an average score of 57 out of 100, based on 28 critics, indicating "mixed or average reviews". Audiences polled by CinemaScore gave the film an average grade of "B-" on an A+ to F scale.