The complexity of the Re.2001 design led to higher costs (in 1942, the production cost of the Re.2001 was 600,000 lire versus 520,000 lire of the Macchi C.202) and slowed production rates which also limited its effectiveness as a fighter. Due to attrition, only 33 Re.2001s were available at the Armistice of 9 September 1943. Furthermore, poor serviceability meant that only nine Re.2001s survived the division of Italy, eight going to the Italian Co-Belligerent Air Force with the Allies, and one to the Italian Social Republic.