Born Sarah Augusta Tilghman in Baltimore, Maryland, she was the daughter of James Cooke and Elizabeth (Haughton) Tilghman. She went to high school at Western Female High School (now Western High School) in Baltimore, where she was elected president of the freshman class. Standing only five feet one-half inch at maturity, she was described by a classmate as "small but terrible". Her determined personality extended to the athletic field where she participated in intramural track and field, gymnastics, and basketball. Another instance of Hughes's strong personal discipline was seen in her habit of going to bed by 8 pm and getting up at 4 am, a habit she continued through much of her life. After graduating from Western High School, she attended Goucher College, an all women's college in central Baltimore very close to her home. She participated in athletics at Goucher College, and 'learned to lose without bitterness, to get up and try again, to never feel resentment,' a trait that would serve her well through many years of political victories and defeats. She graduated with an Artium Baccalaureus degree in 1917.