The town is located in a midsection of the country, with semi-desert, arid lands to the north and more fertile lands to the south. Winters are relatively cold and summers are hot and rainy. The municipality also includes the towns of San Nicolás de las Flores, Teocaltitán de Guadalupe, San Gaspar de los Reyes and Mitic. In the center of town are the churches that originate from the 16th century, when the town was first founded. Jalostotitlan it's also known for its great religious center, El Señor de la Luz in the locality of Santa María de la O.