In 1944, Sanders had his best year, finishing 15th in the voting for the National League Most Valuable Player Award. He set career highs in batting average, home runs, and runs batted in, helping the Cardinals to return to the 1944 World Series. This time playing against the St. Louis Browns in their only World Series appearance, Sanders hit a home run in Game Five to help the Cardinals to a 2–0 win, with the Cardinals also winning Game Six to close out the Series.