In 1806 he went to the United States where he planned to study the languages of the indigenous people. He married Sarah Duane of Schenectady, New York, on 6 November 1808. They had four children: James, Ann, George Jr., and Georgianna. He farmed, organised the first New York Board of Agriculture, and advocated the building of steam railroads in the United States. Difficulty experienced in the economic transportation of his crops led Featherstonhaugh to advocate a steam railroad that would connect the Hudson River at Albany, New York, with the navigable Mohawk River at Schenectady. His acquaintance with George Stephenson (1781–1848) facilitated his quest. Ten years were spent in an attempt to educate the public for the experiment and it was not until December 1825, that Featherstonhaugh was determined to apply for a charter. This was granted on 17 April 1826.