Once again, the Red Sox took the lead in the first inning when Ramírez hit a home run off former Red Sox pitcher Jeff Suppan. Pedro Martínez was the starting pitcher for the Red Sox, and in the bottom of the first inning, he allowed the Cardinals to load the bases with one out. Edmonds then hit a fly ball towards Ramírez in left field, who caught it on the run and threw to catcher Jason Varitek at home plate. Varitek tagged out Walker, who was attempting to score from third, ending the inning.