Berberian made his Metropolitan Opera debut on April 21, 1979, as Kecal in "The Bartered Bride" in an out of town performance in Cleveland, Ohio. He made his first appearance at the Metropolitan Opera House (Lincoln Center) as Zacharie in Giacomo Meyerbeer's "Le prophète" on September 25, 1979. He sang at the Met for 18 consecutive seasons, portraying more than 100 roles. Some of his more notable roles at the Met included Bouillon in "Adriana Lecouvreur", Bonze in "The Nightingale", Don Basilio in "The Barber of Seville", Geronte in "Manon Lescaut", Hermann in "Tannhäuser", Mustafà in "L'italiana in Algeri", the Old Hebrew in "Samson and Dalila", Osmin in "Die Entführung aus dem Serail", Rocco in "Fidelio", Sparafucile in Verdi's "Rigoletto", Spinelloccio in "Gianni Schicchi", Titurel in "Parsifal", and Zacharie in "Le prophète" among many others. In 1991 he created the role of the Turkish Ambassador in the world premiere of John Corigliano's "The Ghosts of Versailles". His last performance at the Met was as Benoit/Alcindoro in Puccini's "La boheme" on January 23, 1997.