Smith was signed to the Atlanta Falcons' practice squad on October 21, 2009 after the team waived quarterback D. J. Shockley. After his contract expired following the season, the Falcons re-signed Smith to a future contract on January 4, 2010. Smith has been known mostly as a special teams player while in Atlanta but has done well with his limited carries. In Week 11 of 2013, Smith rushed for 88 yards and a touchdown against the Tampa Bay Buccaneers. Antone Smith also impressed during Week 13 of the 2013 when he rushed for over 50 yards and a touchdown against the Buffalo Bills.