The 2015 season was an inconsistent one for Ryan and the Falcons. In the season opener against the Philadelphia Eagles on "Monday Night Football", he was 23-of-34 for 298 yards with two touchdowns and two interceptions in the 26–24 victory. In the next game against the New York Giants, he was 30-of-46 for 363 yards and a touchdown in the 24–20 victory. The Falcons won the next three games for a 5–0 start. Their first loss came in the sixth game with a 31–21 setback against the New Orleans Saints, where Ryan was 30-of-44 for 295 yards and two touchdowns. After a 10–7 victory over the Tennessee Titans, the Falcons dropped their next six games to send their season plummeting. In the losing streak, Ryan had a season-high 397 passing yards for two touchdowns and an interception in a 23–20 loss to the Tampa Bay Buccaneers in Week 8 on November 1.