In 1999, Epstein returned to his hometown of Holyoke, Massachusetts, to record the demise of his father's two businesses—a retail furniture store and a low-rent real estate empire. The resulting project assembled large-format photographs, video, archival materials, interviews and writing by the artist. The book, "Family Business," which combined all of these elements, won the 2004 Krazna-Kraus Best Photography Book of the Year award. In reviewing the book, Nancy Princenthal wrote in Art in America, “The family business chronicled by Mitch Epstein was a small-town retail furniture with a sideline in real estate, and his patiently plotted bell curve of its history is worthy of Dreiser….” In 2004, his work was exhibited during evening screenings at Rencontres d'Arles festival (at the Théatre Antique), France.