In Pythagorean tuning, and any kind of meantone temperament tuning system that tempers the fifth to a size larger than 700 cents (such as -comma meantone), the comma is the opposite of a diminished second, and therefore the opposite of the above-listed differences. More exactly, in these tuning systems the diminished second is a descending interval, while the comma is its ascending opposite. For instance, the Pythagorean comma (531441:524288, or about 23.5 cents) can be computed as the difference between a chromatic and a diatonic semitone, which is the opposite of a Pythagorean diminished second (524288:531441, or about −23.5 cents).