He has been instrumental in founding 15 biotechnology companies, including Amgen, Applied Biosystems, Systemix, Darwin, Rosetta Inpharmatics, Integrated Diagnostics, and Accelerator Corporation. In 2015, he co-founded a startup called Arivale offering a subscription-based 'scientific wellness' service which shut down in 2019. While praising the quality of its offering, industry commentators attributed Arivale's closure to a failure to capture sufficient Customer lifetime value to create a profit from providing the service, suggesting that insufficient numbers of customers stuck with the data-driven, personalized dietary and lifestyle coaching it provided for long enough at a price point which would make the business model work.