I-664 has a southbound vehicle inspection station adjacent to its first interchange in Newport News, with Terminal Avenue. The Interstate parallels the southern end of CSX's Peninsula Subdivision as it passes through interchanges with several streets to the east of downtown Newport News. The southern interchange has ramps to and from 25th, 26th, and 27th streets; the first two streets carry eastbound and westbound US 60, which is unmarked from I-664. The northern interchange has ramps to and from 35th Street and Jefferson Avenue; Jefferson Avenue is SR 143, which is also unmarked from the Interstate. I-664 curves east as a six-lane freeway away from the railroad and has an oblique crossing of SR 351 (39th Street) prior to half-diamond interchanges with Roanoke Avenue and Chestnut Street. The Interstate enters the city of Hampton and has diamond interchanges with Aberdeen Road and Powhatan Parkway before reaching its northern terminus at I-64. I-664 meets its parent highway at a directional T interchange above Newmarket Creek just south of Hampton Coliseum.