She had a minor role in "The Darwin Awards" (2007). In 2008, Margulies starred in the legal series "Canterbury's Law," a Fox mid-season replacement show. She played the title character, Elizabeth Canterbury, a lawyer described as a "tough-minded defense attorney who isn't afraid to push boundaries in order to protect innocent clients." She was also credited as a producer of the show. The series was severely affected by the 2007–2008 Writers Guild of America strike; it was cancelled by the network after only six episodes.