"Preble" deployed on 17 January 2009 for a routine deployment with the "Stennis" Carrier Strike Group where she spent five months in the Seventh Fleet area of responsibility, participated in Exercise Foal Eagle and culminated the deployment with a diplomatic port visit in Tahiti, French Polynesia. "Preble" returned to home port on 15 June 2009. In 2010 "Preble" shifted to align with the Strike Group and hosted sailors from the Royal New Zealand Navy. The and replenishment tanker conducted exercises with "Preble" during a 3-day underway period. Additionally, "Preble" was called to act as the lead ship for a Destroyer Squadron Seven multi-group sail that showcased the ship's anti-submarine warfare capabilities.