A second test flight, at the suggestion of Prof. Henry, was made from Cincinnati and was to return him to the eastern seaboard. For this flight he used the smaller balloon "Enterprise". His flight took off on the early morning of April 19, 1861, two days after Virginia had seceded from the Union. The flight misdirected him to Unionville, SC, where he was put under house arrest as a Yankee spy. Having established his identity as a man of science, he was allowed to return home, where he had received word from Secretary of the Treasury Salmon P. Chase to come to Washington with his balloon. The American Civil War permanently ended Lowe's attempt at a transatlantic crossing.