Madame Web (Cassandra Webb) is a fictional character appearing in American comic books published by Marvel Comics. She first appeared in "The Amazing Spider-Man" #210 (November 1980) and was created by writer Denny O'Neil and artist John Romita Jr. She is usually depicted as a supporting character in the "Spider-Man" comic book series. She is depicted as an elderly woman with myasthenia gravis and thus was connected to a life support system that looked like a spider web. Due to her age and medical condition Madame Web never actively fought any villains.