When Yhwach absorbed the Soul King's power, Mayuri and Kenpachi come across Pernida Parnkgjas in the transformed Royal Realm. After Pernida defeats Kenpachi, deeming the mysterious Wandenreich to be creepy for even him, Mayuri finds himself in a battle for his life after Perinda reveals himself to be the left arm of the Soul King. After his attempt to defeat Perinda with a variation of his Konjiki Ashisogi Jizō failed, realizing the arm is constantly evolving, Mayuri finds himself being protected by Nemu before she throws him over to a nearby building to watch her fight with the arm unfold. Though Nemu dies while having visions of being taunted by Szayelaporro, Mayuri saves his creation's brain from being eaten by Perinda so the Quincy would die an antagonizing death from her cellular makeup. In the series epilogue, Mayuri created a new Nemu.