Unbeknownst to the duo, Thrax has survived the zit's destruction and, after killing his remaining henchmen, launches a lone assault on the hypothalamus, where he steals a crucial nucleotide. He then abducts Phlegmming's secretary, Leah Estrogen, and flees to the mouth to escape. His actions disable the body's ability to regulate temperature and a dangerous fever develops, causing mass panic to erupt in the city. As Frank is taken to the hospital, Ozzy, having discovered Thrax's survival, convinces a dejected Drix not to leave, and the two catch up to Thrax and rescue Leah. However, Thrax uses pollen to induce Frank to sneeze and blow him out of the mouth onto Shane's eye. Drix shoots Ozzy out of the mouth after Thrax, where they land on Shane's cornea and a fight between them breaks out. As they end up on one of Shane's false eyelashes, Thrax appears to gain the upper hand and threatens to make Shane his next victim, but Ozzy, having outsmarted Thrax by tricking him into getting his hand embedded in the lash, escapes just as Shane's lash falls off her face at the last minute and into a beaker of rubbing alcohol, where Thrax dissolves.