In the Week 5 game against the San Francisco 49ers, he completed 15 of 21 passes for 258 yards in the first half, setting a new career-high for the first half of play. Ryan finished the 45–10 victory having completed 22 of 32 passes for 329 yards and two touchdowns for a 110.0 passer rating. Ryan tossed a 31-yard strike to Roddy White, and he connected to White again in the second quarter with a 90-yard touchdown. The pass and reception for Ryan and White set new career highs. The pass and reception also mark the third longest in franchise history and the longest pass play since 2001. The game was his third-career 300-yard passing outing as the second-year quarterback set a new career-high in total passing yards with 329 in a single game.