Whannell was writer-director of the science fiction body horror film "Upgrade", which was released by Blumhouse Tilt and OTL Releasing in 2018 to positive reception. Whannell next wrote, directed, and co-executive produced a retooling of H.G. Wells' book "The Invisible Man". The film starred Elisabeth Moss and Oliver Jackson-Cohen, and was released in 2020 to universal critical acclaim. In July 2020, it was announced that he's working on a sequel to "The Invisible Man". Whannell is currently working on a reboot of "Escape from New York". He's also producing and directing a sequel series to "Upgrade". He is in talks to direct a remake of The Wolf Man with Blumhouse Productions producing and starring Ryan Gosling.