In series one, the programme began with Bailey introducing the show and playing its theme tune, which he performed in a slightly different way in each episode. In subsequent series, the theme tune was, instead, performed by House of Strange Studios of East London. The host/professor and the curator/sidekick introduce themselves. They then give a short guide to the museum, followed by the introduction of the "advisory committee", a guest panel made up of celebrities and academic experts, during which Lloyd reads their CVs aloud.