In February 2016, Wozniak advanced to the quarterfinals of the $25k in Surprise, Arizona. She used her protected ranking to enter the main draw of the French Open, her first Grand Slam main draw since the 2014 US Open, but was defeated by Yulia Putintseva in the opening round. At the end of July, using again her protected ranking, she entered the singles main draw of the Citi Open where she lost to Jessica Pegula in the first round. The next week, she received a wildcard into the main draw of the Rogers Cup and lost in the first round to Sara Errani. She next played the Challenger de Granby, a $50k event, and reached the semifinals.