PA 53 enters Beccaria Township in Clearfield County and becomes North Glendale Boulevard, heading north through more forests to the east of Clearfield Creek. The road intersects the northern terminus of PA 865, where it crosses into the borough of Coalport and becomes Main Street, passing homes and businesses. The route heads back into Beccaria Township and continues into the community of Blain City, turning east and north along Dorsey Avenue. PA 53 heads northwest through wooded areas with some fields and homes, crossing into the borough of Irvona. The road crosses Clearfield Creek and runs north through residential and commercial areas before turning east. The route reenters Beccaria Township and becomes Glen Hope Boulevard, heading into forested areas with some homes and turning north. PA 53 turns east and north again through more woods with some fields and residences, continuing into the borough of Glen Hope. The road heads northeast into residential areas, crossing PA 729. The route heads back into rural areas and crosses into Bigler Township, becoming Main Street and continuing to the northwest of Clearfield Creek. PA 53 comes to an intersection with PA 453 and forms a concurrency with that route, crossing the creek and heading into the residential community of Madera, where PA 453 splits to the south.