5-10% of all racemates are known to crystallize as mixtures of enantiopure crystals, so-called conglomerates. Louis Pasteur was the first to conduct chiral resolution when he discovered the concept of optical activity by the manual separation of left-handed and right-handed sodium ammonium tartrate crystals in 1849. In 1882 he went on to demonstrate that by seeding a supersaturated solution of sodium ammonium tartrate with a d-crystal on one side of the reactor and a l-crystal on the opposite side, crystals of opposite handedness will form on the opposite sides of the reactor.