In 1925, the Soviet Air Force approached TsAGI with a requirement for a heavy bomber with total engine output of and either wheeled or float landing gear. Tupolev OKB started design work in 1926 with the government operational requirements finalized in 1929. The Tupolev TB-1 was taken as the basis for the design and the aircraft was initially powered by Curtiss V-1570 "Conqueror" engines, with the intent of switching to Mikulin M-17s (modified BMW VIs) in production. The mock-up was approved on 21 March 1930 and the first prototype was completed on 31 October 1930. The aircraft flew on 22 December 1930 with Mikhail Gromov at the controls and with ski landing gear. Despite almost crashing owing to vibration causing the throttles to close, the test flight was a success. On 20 February 1931, the Soviet Air Force approved mass production of the ANT-6 with M-17 engines.