Produced by and the Farrelly brothers' Conundrum Entertainment, "Osmosis Jones" premiered at Grauman's Egyptian Theatre on August 7, 2001 before being released in general theaters three days later on August 10, 2001. The film was met with mixed-to-positive reviews from critics, who praised the animated scenes, the voice cast (particularly Rock's, Pierce's and Fishburne's) and plot, but criticized the live-action portions and the overuse of gross-out humor. The film was also a box-office bomb, earning $14 million against a budget of $70 million, though it later sold well in home media. A spin-off animated television series titled "Ozzy & Drix" later ran on Kids' WB from 2002 to 2004, in which the titular characters suddenly get removed and exiled by a mosquito that transfers them to the body of a teenage boy named Hector Cruz and continue their battle against germs and viruses from in it as Private investigators. In addition, all episodes use scenes from its movie counterpart.