With the rise of sophisticated treatment modalities such as gamma knife, cyber knife, and intensity modulated radiotherapy, a large number of individuals with brain tumors are treated with radiosurgery and radiotherapy. Radiation-induced brain edema (RIBE) is a potentially life threatening complication of brain tissue radiation and is characterized radiation necrosis, endothelial cell dysfunction, increased capillary permeability, and breakdown of the blood brain barrier. Symptoms include headache, seizure, psychomotor slowing, irritability, and focal neurological deficits. Options for management of RIBE are limited and include corticosteroids, anti platelet drugs, anticoagulants, hyperbaric oxygen therapy, multivitamins, and bevacizumab.