In the early 16th century, the Spanish Casa de Contratación (House of Trade) established and held a trade monopoly in the first manufacturing industries of snuff, in the City of Seville, which became Europe's first manufacturing and development centre for snuff. The Spanish called snuff "polvo" or "rapé". At first they were independent production mills dispersed within the city, state control over the activity later concentrated the production to one location opposite the Church of San Pedro. By the mid-18th century it was decided to build a large and grand industrial building outside the city walls, and thus the Royal Tobacco Factory ("Real Fábrica de Tabacos") was built, becoming Europe's first industrial tobacco factory, producing snuff and auctioning tobacco at first, and Spain's second largest building at the time.