Maria Regina offers a rigorous college preparatory program. Graduation requires successful completion of the four-year course of study. A total of at least 26 credits is required. The Maria Regina program includes four years of mathematics, english, social studies, and theology; three years of science and a foreign language; and one year of art and music, although many students opt to take four years of science and a foreign language, and more than one year of art. Physical Education and Health are also requirements for graduation. Honors classes are available in all disciplines, except theology, and AP classes are offered in classes such as Biology, Chemistry, English Literature, American History, and European History. There is also a wide variety of electives to choose from for juniors and seniors, such as Introduction to Law, 3D Printing, and Criminal Justice.