The first more or less permanent settlement at present-day New Madrid was established by bands of Shawnee, Delaware, Creek, and Cherokee who were turned into refugees due to the U.S. War for Independence. These refugee Native American bands accepted Spanish offers to settle on the west bank of the Mississippi River in the early 1780s. These mixed Native American groups established a settlement and informal trading post where a northward, horseshoe bend of the Mississippi met the Chepusa creek, which provided an easy place for landing boats. Native American hunters and Europeans-American merchants made the settlement a location for processing the bounty of hunts, including the valuable but messy fat of bears and buffalo, which was used in preparing skins and furs. The settlement quickly acquired the name L’Anse a la Graise – “Cove of Grease” or “Greasy Cove.”