In 2009, Ryan started off the season fast as he threw for 229 yards and two touchdowns with no interceptions as he led the Falcons to a 19–7 win against the Miami Dolphins in the 2009 NFL season opener. In Week 2, Ryan led the Falcons past the Carolina Panthers. Ryan had a career-high in touchdown passes (3), completion percentage (78%) and touchdown passes in a half (3). He finished the game 21–28 with 220 yards, three touchdowns, and an interception. In Week 3, Ryan and the Falcons lost to the New England Patriots. Ryan completed 17–28 for 199 yards with no touchdowns or interceptions in the 26–10 loss.