After refitting, "Nizam" was attached to the British Eastern Fleet, and participated in sweeps of the Indian Ocean for enemy ships. She was then reassigned to the South Atlantic for shipping protection. On 13 July 1943, the destroyer rescued survivors from an American liberty ship sunk by . On 31 July, "Nizam" rescued survivors from a British merchant ship sunk by . After delivering the British survivors ashore, "Nizam" made for Australia, and docked in Melbourne on 18 August for an eight-week refit. The ship returned to operations in the Indian Ocean, and on 17 October was unsuccessfully fired on by a German U-boat. Between late 1943 and early 1944, the destroyer was based in Kenya, then was transferred on 8 March to the Bay of Bengal. During her time based here, "Nizam" participated in Operation Cockpit, a carrier air raid on Japanese assets in south-east Asia. In November, the destroyer sailed to Melbourne for another refit. In a tragedy which harked back to that of 21 October 1941, on 11 February 1945, while crossing the Great Australian Bight in poor weather after the refit, "Nizam" was hit by a freak wave which caused the ship to roll almost eighty degrees to port, and washed ten sailors overboard, none of whom were ever seen again.