Two years later, facing a serious challenge to his reelection prospects, Mayor Phlegmming doubles down on his junk food policies, ignoring their effect on Frank's health. This causes Frank to eat a boiled egg covered in filth, allowing Thrax, a deadly virus known as "The Red Death", to enter the throat. Unwilling to admit responsibility, Phlegmming instructs Frank to take a cold pill through brain signals. The pill, Drixenol "Drix" Koldreliff, proceeds to disinfect the throat, covering up any evidence of Thrax's arrival. To his displeasure, Ozzy is subsequently assigned to assist the stoic and straight-laced Drix in his investigation. Meanwhile, Thrax assumes leadership of a gang of sweat germs and launches an attack on the mucus dam in Frank's nose, nearly killing Drix before Ozzy rescues him.