In 1965, 28-year-old Adair hit .259 with 7 home runs and a career-high 66 RBI in 157 games with the Orioles. He was among American League leaders with 157 games (8th in the AL), 582 at bats (10th in the AL), 26 doubles (7th in the AL), 115 singles (10th in the AL) and 6 sacrifice flies (8th in the AL). As a result, Adair finished 17th in the AL MVP vote that was won by Zoilo Versalles of the Minnesota Twins.