As of 2020, Skoll has been working for over ten years to help prevent pandemics and other global threats. In 2009, Skoll donated $100 million to create the Skoll Global Threats Fund to confront threats including climate change, water security, pandemics, nuclear proliferation, and Middle East conflict. The Fund created and spun off a stand-alone non-profit entity, Ending Pandemics, that focuses on pandemic detection and response. In 2011, Skoll's film company Participant co-produced the film "Contagion" to raise awareness about the dangers posed by pandemics. Skoll wanted the film be scientifically sound and encourage funding of medical experts; In 2020, following the COVID-19 pandemic media coverage noted it was "shocking in its accuracy".