On November 22, 1940, Jenkins successfully defended his World Lightweight Title against Pete Lello in a second-round knockout at New York's Madison Square Garden before a largely hostile audience of around 11,000. Jenkins knocked Lello down four times in the second, usually with strong blows to the jaw and at least twice for counts of nine. He said after the bout that he had little memory of the bout after his first knockdown in the second. Lello had formerly knocked out Jenkins in a close bout that ended in an early seventh round victory in Chicago on March 24, 1939.