He was sent from Charcas to Asunción, Paraguay in 1721 as an inspector and member of the Audiencia there. His instructions were to investigate charges made by the "cabildo" (city council) of Asunción against the governor of Paraguay, Diego de los Reyes Balmaseda. If the governor's guilt was established, Antequera was to remove him from office, occupy the office himself, and reestablish justice in the province. If, on the other hand, the governor was acquitted, Antequera was to wait until the expiration of his legal term in office, and then take over the government.