The surviving Pinckney sons became influential leaders. Charles Cotesworth Pinckney was a signatory of the United States Constitution and was the Federalist vice-presidential candidate in 1800. In 1804 and 1808, he was the Federalist candidate for president. Thomas Pinckney was appointed Minister to Spain, where he negotiated Pinckney's Treaty in 1795, to guarantee U.S. navigation rights on the Mississippi River to New Orleans. He was the Federalist vice presidential candidate in 1796. Harriott would marry Daniel Huger Horry, Jr. and live at Hampton Plantation, now a South Carolina State Historic Site.