Isaak composed a theme song for U.S. late-night television variety/talk show, "The Late Late Show with Craig Kilborn". In 2001, Isaak starred in his own television show, "The Chris Isaak Show". It aired from March 2001 to March 2004 in the United States on the cable television network Showtime. This adult comedy show featured Isaak and his band playing themselves and the episode plots were based on fictional accounts of the backstage world of Isaak—the rock star next door. In 2004 his track "Life Will Go On" was featured on "Chasing Liberty"'s soundtrack, which starred Mandy Moore and Matthew Goode. His track "Two Hearts" was featured in the closing credits of the 1993 film "True Romance", directed by Tony Scott, written by Quentin Tarantino, and starring Christian Slater and Patricia Arquette.