"Call Me When You're Sober" was written by Amy Lee and Terry Balsamo, while its production and audio mixing were handled by Dave Fortman at Ocean Way Studios in Los Angeles. The programming of the track was finished by DJ Lethal while group member John LeCompt finished the additional programming. Jeremy Parker was responsible for its audio engineering while Ted Jensen served as its master. "Call Me When You're Sober" was recorded at Record Plant Studios in Los Angeles. The instrumentation is provided by the band with Lee playing keyboards, Terry Balsamo playing lead guitar, John LeCompt playing rhythm guitar, Tim McCord playing bass guitar and Rocky Gray playing drums. Lee's sisters, Carrie and Lori Lee, perform the backing vocals during the chorus line "Make up your mind". "Call Me When You're Sober" was one of the last songs recorded for "The Open Door".