By the year 2056, an epidemic of organ failures has devastated the planet. The megacorporation GeneCo provides organ transplants on a payment plan. Clients who miss payments are hunted down by Repo Men, skilled assassins who "repossess" the organs ("Genetic Repo Man"). The CEO of GeneCo, Rottissimo "Rotti" Largo, discovers he is terminally ill. Rotti's three children, Luigi, Pavi, and Amber, bicker over who will inherit GeneCo ("Mark It Up"). Rotti believes none of his children are worthy heirs and instead plans to pass on his fortune to 17-year-old Shilo Wallace, the daughter of his ex-fiancé Marni ("Things You See In A Graveyard").