Krause landed his first role in 1989 as a student in the TV series "TV 101". He then starred in the made-for-TV-movie "Match Point", the "CBS Schoolbreak Special" "American Eyes", and "An American Summer", before landing his first major role as Richard Lestrange, Jr. in the film "Return to the Blue Lagoon" (1991). He was a co-star in the "Bandit" series prior to his most notable role of Leo Wyatt, in The WB Network series "Charmed" (1998–2006). Krause originally auditioned for the role of Andy Trudeau but was cast as Piper's handyman/whitelighter love interest.