The church’s proximity to Billingsgate fish market prompted James Peller Malcolm to write "The narrow streets and alleys and their wet slippery footways will not bear description or invite unnecessary visits". St George's fell into decay during the second half of the 19th century. The last service was held in 1890, and in May 1900 a letter to "The Times" reported that not only had the church been condemned as structurally unsafe, but that the accumulation of human remains in the vault had become a health hazard. The church was closed in 1901 and demolished in 1904, the parish being combined with that of nearby St Mary-at-Hill. Many bodies were disinterred from the churchyard and reburied at Brookwood Cemetery. The site of the church is now occupied by Richard Seifert’s Farryner House of 1973. The churchyard gates survive in Lovat Lane, and a parish boundary mark can still be found on Fish Street Hill.