In 1979, Mazzilli led the Mets with 181 hits and 79 runs batted in, and was their sole representative at the All-Star Game in Seattle. Mazzilli hit a game-tying solo home run in the eighth inning of that All-Star Game, and drew a bases-loaded walk in the ninth inning to bring in the winning run of the National League's 7–6 victory. The following year, he had his best statistical season, leading the Mets with 162 hits, 31 doubles, 16 home runs, 76 RBIs, 82 runs, and 41 stolen bases. He was the only Met to have 2 RBI's in an All Star Game until 2019 when Pete Alonso did so.