McDonald's solo career consists of nine studio albums and a number of singles, including the 1982 hit "I Keep Forgettin' (Every Time You're Near)". During his career, McDonald has collaborated with a number of other artists, including James Ingram, David Cassidy, Van Halen, Patti LaBelle, Lee Ritenour, the Winans, Aretha Franklin, the rock band Toto, Grizzly Bear, Joni Mitchell, and Thundercat. He has also recorded for television and film soundtracks. McDonald is the recipient of five Grammy Awards, and was inducted into the Rock and Roll Hall of Fame as a member of the Doobie Brothers in 2020.