"Irresistible" was included on the setlist of her DreamChaser Tour (2001) and Reality Tour (2004). In the book "People in the News: Jessica Simpson and Nick Lachey", Terri Dougherty wrote that Simpson wanted the DreamChaser Tour to feature her as a singer and dancer, following the model laid down by performers like Britney Spears. Therefore, Simpson made the choreography more risqué by adding backup dancers and performing dance moves in revealing outfits. The song was also performed on MTV's "Total Request Live" Tour in which she was supported by six backup dancers. Her performance was commended by "The Richmond Times-Dispatch", who wrote that her voice "soared," but criticised by "The Buffalo News" Andrea Kibler and "St. Louis Post-Dispatch"s Kevin C. Johnson, both of whom opined that Simpson was lip-syncing the whole song.