Talalay states that ever since "Doctor Who" was revived in 2005, she wanted to work on the show. Talalay directed all three of Peter Capaldi's series finales: series 8's "Dark Water" and "Death in Heaven", series 9's "Heaven Sent" and "Hell Bent"—the former considered by many to be one of the best episodes in the show's -year history— and series 10's "World Enough and Time" and "The Doctor Falls", as well as the "Doctor Who" 2017 Christmas special, "Twice Upon a Time". In 2019, she directed a film adaption of Joe Ballarini's "A Babysitter's Guide to Monster Hunting" for Netflix.