After her television series "Damages" ended, Close returned to film in 2014, in which she played Nova Prime Rael in the Marvel Studios film "Guardians of the Galaxy". She also appeared in the independent movies "5 to 7" (2014) and "Low Down" (2014). In 2016, she appeared in "The Great Gilly Hopkins" and starred in the British zombie horror drama "The Girl with All the Gifts" (2016) as Dr. Caldwell, a scientist researching a cure to save humanity. In 2017, Close appeared alongside Noomi Rapace and Willem Dafoe in "What Happened to Monday", a science fiction thriller produced by Netflix. Also that year, she was reunited with actors John Malkovich (her co-star in "Dangerous Liaisons") and Patrick Stewart (co-star in "The Lion in Winter") in the romantic comedy "The Wilde Wedding", and co-starred in "Crooked House", a film adaptation of the novel by Agatha Christie.