The game features a wide variety of enemies; some of which are aliens and other mutated humans. The LAPD have been turned into "Pig Cops", a play on the derogatory term "pig" for police officers, with LARD emblazoned on their uniforms. As is usual for a first-person shooter, Duke Nukem encounters a large number of lesser foes, as well as bosses, usually at the end of episodes. Like Duke, these enemies have access to a wide range of weapons and equipment, and some weaker enemies have jet packs.