"Burrfish"s war operations extended from 2 February 1944 to 13 May 1945 during which period she completed six war patrols, sinking one 5,894-ton German tanker "Rossbach" in Japanese waters on 7 May 1944 and, along with , a 200-ton patrol boat on 17 November 1944. Her operating area extended from the Western Caroline Islands to Formosa and the waters south of Japan. During her third war patrol the ship accomplished several special missions, conducting reconnaissance of the beaches of Palau and Yap where landings were planned.