During the 1940s the existence of mutants was not yet known to the general public. A few individuals were aware of the coming of "Homo superior" and the fact that they had the potential to replace baseline humans as the dominant species of Earth. Thus Weapon Plus was created to address the so-called mutant problem. What was unknown by everyone involved in Weapon Plus is that its mastermind, John Sublime, was actually the host body for a sentient bacteria present in every living creature on the planet, save for mutants, who were genetically immune to the Sublime infection.