However, the prosperity Aleppo experienced in the 16th and 17th century started to fade as silk production in Iran went into decline with the fall of the Safavid dynasty in 1722. By mid-century, caravans were no longer bringing silk from Iran to Aleppo, and local Syrian production was insufficient for Europe's demand. European merchants left Aleppo and the city went into an economic decline that was not reversed until the mid-19th century when locally produced cotton and tobacco became the principal commodities of interest to the Europeans. According to Halil İnalcık, "Aleppo ... underwent its worst catastrophe with the wholesale destruction of its villages by Bedouin raiding in the later years of the century, creating a long-running famine which by 1798 killed half of its inhabitants."