After promising wins against Jaslyn Hewitt and Kimberly Po at the 2000 Australian Open qualifying, she fell to Kerry-Anne Guse. At Roland Garros, she lost to Desislava Topalova; and at Wimbledon, she lost to Vanessa Webb. She did manage to win a match at the US Open, though, against Sybille Bammer in the qualifying. Sanjeev then went on to represent India at the 2000 Sydney Olympics, playing in the women's doubles event with Manisha Malhotra. The team suffered a defeat at the hands of Australians Jelena Dokic and Rennae Stubbs in round one. Earlier in the 2000, she won her second (and ultimately the last) ITF title in April, winning against Sai Jayalakshmy Jayaram in the $10,000 tournament held on carpet courts in New Delhi. Nirupama won a total of four ITF doubles titles in 2000, and reached a further two finals, making it a career-best season in doubles.