Middletown Area High School is located at 1155 North Union Street, Middletown. In 2015, enrollment had declined to 647 pupils in 9th through 12th grades, with 40.9% of pupils eligible for a free lunch due to family poverty. Additionally, 15% of pupils received special education services, while 6.4% of pupils were identified as gifted. The school employed 49 teachers. Per the Pennsylvania Department of Education, 100% of the teachers were rated "Highly Qualified" under the federal No Child Left Behind Act.