Chambers started 15 games in 2004, missing only an October 3 contest against the New York Jets with a knee injury. He led Miami in both receiving yards and touchdowns with 898 yards and seven scores. His 69 receptions were second on the team only to tight end Randy McMichael's 73. It marked the fourth straight year in which Chambers led the team in receiving yardage, which made him just the third Dolphin ever to achieve this feat, joining Paul Warfield (1970–1973) and Nat Moore (1974–1977). Chambers had six receptions of 25 yards or longer - the most on the team. He also rushed for 76 yards on nine attempts during the course of the season, including a season-long 24-yard run against the Arizona Cardinals on November 7. He led team in receptions seven times and in receiving yards on five occasions during the course of the season. His reception total was 15th in the AFC while his yardage figure ranked 18th. Chambers accounted for four 100-yard receiving games on the year, tied for the sixth-highest single-season figure in club history and the most by a Dolphin since Tony Martin had five in 1999.