In the "Ultimate Six" story arc, Kraven genetically tampers with his DNA, allowing him to become a gruesome werewolf-like monster with large hands and feet, claw-like fingers, enlarged red veins, darker skin, fang-like teeth and berserk-like feral behavior. Kraven is taken in S.H.I.E.L.D. confinement after being taken down by the Ultimates for tampering with his DNA. Kraven eventually escapes with other Spider-Man villains the Green Goblin, Doctor Octopus, Electro, and the Sandman. They capture Spider-Man, tie him up, unmask him, humiliate him, and blackmail him into joining their group as its sixth member. Kraven helps with the attack on the White House, though he is electrocuted by a lightning bolt from Thor when he tries to attack Peter.