Kirkpatrick was at the US Capitol on January 6, 2021 to certify the 2020 presidential electoral college votes when the Capitol was attacked by Donald Trump supporters. Kirkpatrick and her staff were evacuated from their office around 11 AM due to a report about a suspicious object being found in the vicinity. About 45 minutes later, they returned to their office. Shortly thereafter, the building was put on lockdown as rioters breached the Capitol. She called the attack a "cowardly assault on Democracy" and blamed President Donald Trump for inciting the attack. The next day, Kirkpatrick called for the removal of Trump from office, calling the president "unfit to hold office." Kirkpatrick supported the resolution to have Vice President Mike Pence invoke the 25th Amendment to remove Trump from office. Days later, she voted, for the second time, to impeach Trump.