Wasylycia-Leis resigned her seat on August 12, 1993, to seek (and win) the federal NDP nomination in the riding of Winnipeg North. The NDP fared poorly in the 1993 election, however, and Wasylycia-Leis lost to Liberal Rey Pagtakhan by almost 10,000 votes. She subsequently became a co-chair of Cho!ces, a Manitoba social-justice coalition. In the 1997 federal election, Wasylycia-Leis ran in the riding of Winnipeg North Centre, and defeated Liberal Judith Optiz Silver, 13,663 votes to 7,801. She was re-elected by a wider margin in the 2000 election. In 2003, she supported Bill Blaikie's campaign to become leader of the federal NDP. Redistribution placed Wasylycia-Leis against Pagtakhan again for the 2004 federal election, in the altered riding of Winnipeg North. On this occasion, Wasylycia-Leis defeated Pagtakhan 12,507 votes to 9,491.