Debub Region, also known as the South Region (), is a region of Eritrea. The region was formed on 15 April 1996, from the historical provinces of Serae and Akele Guzai. It lies along a portion of the national border with Ethiopia. As of 2005, the region had a population of 952,100 compared to a population of 839,700 in 2001. The net growth rate was 11.81 per cent. The total area of the province was 8000.00 km2 and the density was 119.01 persons per km2. The highest point in Eritrea, is Mount Soira , is located in the region, situated east of Senafe. It shares borders with Central Region in the north, Zoba Northern Red Sea in the east, Gash Barka in the west and Ethiopia in the south. It is the largest region in the country by population.