In September 2010, "Preble" conducted an Operational Test Launch of two Block 3C Tomahawk missiles and one Block 4E Tomahawk missile off the coast of San Nicholas Island. The launch was successful and aided in the further development of the weapon system. "Preble" participated in an Integrated Anti-Submarine Warfare Course at sea as well as three weeks of exercises with "Ronald Reagan" and sister ships in Destroyer Squadron Seven during the Composite Unit Training Exercise (COMPTUEX) in October to November 2010. In November 2010, "Preble" successfully conducted a Mark 54 torpedo technical evaluation in support of the Naval Undersea Warfare Center's development of the torpedo. "Preble" accurately fired six MK 54 torpedoes during the evaluation.