As the #2-seed in the NFC Playoffs, Ryan led the 11–5 Falcons to a 36–20 home victory over the #3-seed Seattle Seahawks in the . Ryan passed for over 300 yards and had three touchdowns. In the , Ryan led the Falcons to a 44–21 home victory over the Green Bay Packers. Ryan threw for 392 yards for four touchdowns and no interceptions. He also ran for a fifth touchdown, just the fourth player to do so in a post-season game, as the Falcons earned a trip to Super Bowl LI. The game against the Packers was the last one ever played at the Georgia Dome. During Super Bowl LI against the New England Patriots, Ryan finished with 284 passing yards, two touchdowns, and a lost fumble. Although the Falcons led 28–3, it became the subject of one of the most historic downfalls in sports history as the Falcons lost the Super Bowl 28–34 in overtime. Ryan became the first quarterback in franchise history to pass for over 1,000 yards in a single postseason. Of the quarterbacks to achieve the feat, he achieved the highest passer rating, 135.3, and joined Joe Flacco as the only ones to not throw a single interception.