In 1523 Audley was returned to Parliament for Essex, and represented this constituency in subsequent Parliaments. In 1527 he was Groom of the Chamber, and became a member of Wolsey's household. On the fall of the latter in 1529, he was made Chancellor of the Duchy of Lancaster, and the same year Speaker of the House of Commons, presiding over the famous assembly styled the Reformation Parliament, which abolished the papal jurisdiction. The same year he headed a deputation of the Commons to the king to complain of Bishop Fisher's speech against their proceedings. He interpreted the King's "moral" scruples to parliament concerning his marriage with Catherine of Aragon, and made himself the instrument of the King in the attack upon the clergy and the preparation of the Act of Supremacy.