In the 8–0 start, Ryan posted four games with three touchdown passes and three games going over the 300-yard passing mark. The first loss of the season for the Falcons came in Week 10 against the New Orleans Saints. Ryan was 34-of-52 for a then career-high 411 yards and three touchdowns and one interception as the Falcons fell by a score of 31–27. In the next game against the Arizona Cardinals, Ryan threw for 301 yards but had a career-worst five interceptions. Despite the turnovers, the Falcons won by a score of 23–19. In the penultimate game of the regular season, he was 25-of-32 for 279 yards and four touchdowns in a 31–18 victory over the Detroit Lions to his third career NFC Offensive Player of the Week nod.