Entering the 2012–13 season, McDermott had Creighton in the rankings in both preseason polls; they were No. 15 in the USA Today Coaches Poll and No. 16 in the AP Poll. McDermott would lead Creighton to the MVC regular season championship, and its second straight MVC conference tournament championship. The Bluejays were ranked as high as No. 10 in the nation and finished sixth nationally in home attendance for the second consecutive year. The Bluejays received an automatic bid to the NCAA Tournament, where they were the No. 7 seed in the Midwest Region. Creighton would defeat Cincinnati 67-63 in the first round, and lose to Duke 66-50 in the second round.