An accompanying music video for the song was directed by Marc Webb and filmed in Hollywood; it draws inspiration from the fairy tale "Little Red Riding Hood". It features British actor Oliver Goodwill as the Big Bad Wolf, trying to seduce Lee. The video was noted to contain metaphorical undertones as opposed to the song's literal lyrics. "Call Me When You're Sober" was part of the set lists during three of Evanescence's worldwide tours; The Open Door Tour (2006–07), the Evanescence Tour (2011–12) and the band's fourth worldwide tour (2016–17). It has been covered by "American Idol" contestant Gina Glocksen and used in several video games, including "Rock Band".