East of Gervais Street North, Highway 101 travels northeast to Hoyle, passing beside several large open pit mines on the outskirts of Timmins. It then turn east and crosses the Frederick House River on the northern shores of Night Hawk Lake. The route passes through the only agricultural area along its journey, travelling straight for the remainder of the distance to Highway 11 west of Matheson. After a concurrency with Highway 11, Highway 101 branches north into Matheson, where it crosses the Black River before curving east. Returning to wilderness, the route zig-zags towards the Ontario–Quebec border near Rouyn-Noranda, travelling several kilometres south of Lake Abitibi. The roadway continues eastward as Quebec Route 388 into the Abitibi-Témiscamingue region. With the exception of an undivided urban four lane section through Timmins, from Government Road in Mountjoy to Gervais Road South in Porcupine, the entire highway is two lanes wide.