February saw Querrey compete in Memphis where he fell in his opening match to eventual champion Ryan Harrison. He then competed at Delray Beach where he fell in the quarterfinals to Juan Martin del Potro in straight sets. At the ATP Acapulco tournament he beat David Goffin, Dominic Thiem, and Nick Kyrgios, before defeating world No. 6 Rafael Nadal for his first career victory over the former world No. 1 player and his ninth career ATP singles title. At Wimbledon, Querrey defeated Murray in five sets to earn a spot in his first semi-final at Wimbledon. Querrey lost to Marin Čilić in the semifinals in 4 sets. Furthering his success in Mexico, he won the 2017 Los Cabos Open in August, defeating Thanasi Kokkinakis in the final.