In 1993 Meadows helped design WELL.com, the world's third dot-com, and also helped develop the first open-protocol 3D multi-user environment in 1995. He worked as researcher and artist at Xerox-PARC, as Creative Director for a Stanford Research Institute venture, and as creative director and co-founder of a VR and Internet company, which he co-founded, named Construct. In 2001 he opened a gallery in Paris where he sold his paintings for two years before spending time in the Waag Society in Amsterdam, the Netherlands as a researcher. In 2005 he founded HeadCase Humanufacturing, and in 2012 he founded Botanic, formerly Geppetto Labs, both companies dedicated to artificial intelligence and avatars.