At the intersection with Montgomery Street, MD 2 splits into another one-way pair with the northbound direction running east on Montgomery Street and then turning north on Light Street, intersecting MD 2 Truck (Key Highway) and passing by the Maryland Science Center, and the southbound direction following Hughes Street to Hanover Street. Along this one-way pair, the route carries one lane in each direction with the exception of Light Street, where the northbound direction has four lanes. Both directions of MD 2 join again along eight-lane divided Light Street and the route heads toward the Inner Harbor. Near Harborplace, the route splits into another one-way pair with northbound MD 2 running along three-lane Calvert Street and southbound MD 2 running along four-lane St. Paul Street. The route crosses many streets in downtown Baltimore, including Pratt Street, Lombard Street, Baltimore Street, Fayette Street, and Saratoga Street. The one-way pair passes by Mercy Medical Center before coming to US 40. Calvert Street passes under US 40 (the Orleans Street Viaduct) while St. Paul Street splits into two roadways between Lexington Street and Centre Street, with the left roadway passing under US 40 and the right roadway intersecting US 40 as it follows the one-way pair of Franklin Street westbound and Mulberry Street eastbound.