New York State Route 251 (NY 251) is an east–west state highway in western New York in the United States. It extends for from NY 383 in Scottsville, Monroe County, to NY 96 in the town of Victor, Ontario County. NY 251 connects to Interstate 390 (I-390) in Rush and serves the village of Honeoye Falls (via NY 65) and the hamlet of Mendon within the town of the same name. The route, a two-lane, rural highway for much of its length, also intersects NY 15 and NY 64, two north–south highways leading to the Southern Tier and the Finger Lakes, respectively. Two sections of the route—from south of Scottsville to Rush and from Mendon to western Victor—follow linear east–west alignments. All but of the route are located in Monroe County.