On May 27, 2016, Granderson hit a walkoff home run against the Los Angeles Dodgers. He was the first batter up in the bottom of the 9th inning. As of June 16, 2016, Granderson had hit 17 leadoff homers since joining the Mets in 2014, a franchise record. On September 17, Granderson hit two solo home runs against the Minnesota Twins at Citi Field. The first tied the ballgame in the bottom of the 11th inning and the second won the game in the bottom of the 12th inning. He became only the eighth player in Major League history to hit multiple home runs in extra innings of the same game.