Several species, including "Monarda fistulosa" and "M. didyma", have a long history of use as medicinal plants by many Native Americans, such as the Blackfoot, Menominee, Ojibwa and Winnebago. The Blackfoot recognized the strong antiseptic action of the plants, and used them in poultices for skin infections and minor wounds. Native Americans and later settlers also used it to alleviate stomach and bronchial ailments. A tisane made from the plant was also used to treat mouth and throat infections caused by dental caries and gingivitis. Bee balm is a natural source of the antiseptic compound thymol, the primary active ingredient in some modern commercial mouthwash formulas. The Winnebago used a bee balm tisane as a general stimulant. Bee balm was also used as a carminative herb by Native Americans to prevent excessive flatulence. An infusion of crushed, boiled "Monarda" has been used to treat headache and fever.