In 1963, Samuel Boynton died. It was a time of increased activism in the Civil Rights Movement. Amelia made her home and office in Selma a center for strategy sessions for Selma's civil rights battles, including its voting rights campaign. In 1964, Boynton ran for the Congress from Alabama, hoping to encourage black registration and voting. She was the first female African American to run for office in Alabama and the first woman of any race to run for the ticket of the Democratic Party in the state. She received 10% of the vote. She was also part of the steering committee of the Dallas County Voters League, becoming part of the "courageous eight".