A member of the great patrician "gens" Cornelia, he was the son of Scipio Nasica Corculum, the pontifex maximus and princeps senatus. As with many other Cornelii Scipiones, Serapio obtained several prominent offices; he notably succeeded his father as pontifex maximus in 141 BC, and became consul in 138 BC. A firm conservative, like his father and his cousin Scipio Aemilianus, he led the opposition to the tribune of the plebs Tiberius Gracchus, whom he finally murdered in 133 BC. However, he was sent to Asia by the senate to avoid his prosecution by Gracchus' supporters, and died in Pergamum soon after.