In the specialty's infancy, dental and oral surgeons were plenary in the introduction of anesthesia to modern medicine and the development of modern surgery. In 1844, at Harvard Medical School's Massachusetts General Hospital, dentist, Dr. Horace Wells was the first to use anesthesia, but with limited success. On 16 October 1846, Boston oral surgeon, Dr. William Thomas Green Morton gave a successful demonstration using diethyl ether to Harvard medical students at the same venue. In one of the most important and well documented events in American medical history, Morton was invited to Massachusetts General Hospital to demonstrate his technique for painless surgery. After Morton had induced anesthesia, Dr. John Collins Warren, a founding member of Massachusetts General Hospital, the hospital's first surgeon, and the first Dean of Harvard Medical School, removed a tumor from the neck of patient, Edward Gilbert Abbott. The demonstration was performed in the surgical amphitheater now called the Ether Dome at Harvard. Massachusetts General Hospital views the demonstration as among the institution's most significant claims to fame. Upon the successful completion of Dr. Morton's demonstration, Dr. Warren famously proclaimed to the crowded, astonished and elated amphitheater, what would become likely the most famous words in modern medicine, "Gentlemen, this is no humbug." Indeed, the event marked the beginning of modern anesthesia and surgical practice.