The 2004–05 season was the most successful in the club's history. As rookies, they won the regional Adriatic League. Hemofarm finished the regular season in first place in the standings, and at the Final Eight in Belgrade, they eliminated Bosna, FMP and Partizan in the final. That same season, Vršac was again hosting the final tournament of the National Cup, but Hemofarm lost to Budućnost in the first game. In the ULEB Cup, they reached the semifinals, where they were stopped by the Greek team Makedonikos.