She was a strong supporter of President George W. Bush's reelection bid in the 2004 presidential election. On the day of the election, when afternoon exit polls showed Bush losing, she relayed information from Bush campaign insiders that cast doubt on the poll methodology. Afterwards, she supported preventing Arlen Specter from replacing Orrin Hatch as head of the United States Senate Committee on the Judiciary during the period between the 2004 elections and the beginning of the new Senate term in January 2005. Later in 2005, Lopez criticized the Supreme Court nomination of Harriet Miers. She has taken positions against gender quotas, e.g., for university admissions. In 2006, she supported the unsuccessful re-election campaign of Rick Santorum to the United States Senate. She was also a vocal supporter of Mitt Romney's bid for the Republican presidential nomination in 2008.