On the world designated Earth-772, in "What If?", Spider-Man joined the Fantastic Four, but his presence resulted in Sue feeling increasingly sidelined in favour of the four male members of the team, resulting in her leaving the team to marry the Sub-Mariner. Although Reed was briefly driven insane and declared war on Atlantis, he eventually recovered and the two apparently reconciled, resulting in the 'Fantastic Five' reforming once again in time to confront Annihilus in the Negative Zone to help Susan give birth.