Hemofarm's top league status was achieved in the 1997–98 season, under the guidance of coach Slobodan Lukić. The first season among the elite kept their survival, but the following season, 1999–2000, they finished fourth in the standings, providing a first participation in Europe – in the Korać Cup. As newcomers to the competition, the 2000–01 season, led by coach Željko Lukajić, they reached the finals, where they were stopped by Spain's Unicaja Málaga, which was headed by Božidar Maljković. That same year, the team's quality was confirmed with placement at the National Cup final tournament, which was organized in Vršac for the first time, at the opening of the Millennium Centar.