Madhubala had a ventricular septal defect (a hole in her heart) which was detected while she was shooting for "Bahut Din Huwe" in Madras in 1954. This was in the era before open heart surgeries were possible. The natural history of an unrepaired ventricular septal defect leads to pulmonary hypertension and Eisenmenger's syndrome. At this stage the hole cannot be repaired. Hence, she could never undergo a heart surgery later in life, when open heart surgeries were possible in some Western countries like the United States. By 1960, her condition had become aggravated, and as her sister Madhur Bhushan explains that due to her ailment, her body would produce extra blood, so it would spill out from her nose and mouth. The doctor would come home and extract bottles of blood. As a result of the ventricular septal defect, blood would bypass her lungs leading to low oxygen levels and giving her a blue discoloration. As a compensatory mechanism, the body produced more red blood cells making the blood too thick. Hence, the doctors had to extract the excess blood to prevent complications. She was confined to bed for nine years and was reduced to just bones and skin. Unfortunately, there was no surgery or medicine available at that time to treat her.