That same year he got his best-known role as Deano Wicks in the popular BBC soap opera "EastEnders" where he made his first appearance on 2 January 2006. It was announced on 18 August 2007 that Di Angelo would be leaving "EastEnders" following the departure of Phil Daniels (who played his on-screen stepfather Kevin Wicks). He described his departure as "a shock". Di Angelo finished filming "EastEnders" 12 December 2007 and his last appearance in the series aired on 7 February 2008.