In the 2007 Orange Bowl, Brohm earned MVP honors by leading Louisville to its first-ever BCS victory, 24–13 over Wake Forest. Brohm completed 24 of 34 passes for 311 yards, the third highest total in Orange Bowl history. He also ended the year as the 2nd Team All Big East Quarterback behind Pat White. "The Sporting News" projected Brohm as high as the top pick in the 2007 NFL draft, and many other experts had projected him as going no later than the first round, Brohm announced on January 15, 2007, after a long period of speculation, that he would return to the University of Louisville for his senior year.