After the inauspicious start to her tenure as Queen of Spain, Victoria Eugenie became isolated from the Spanish people and was unpopular in her new land. Her married life improved when she gave birth to a son and heir-apparent to the kingdom, Alfonso, Prince of Asturias. However, while the baby prince was being circumcised, the doctors noted that he did not stop bleeding — the first sign that the infant heir had haemophilia. Victoria Eugenie was the obvious source of the condition, which was inherited by her eldest and youngest sons. Contrary to the response of Emperor Nicholas II of Russia, whose son and heir by another granddaughter of Queen Victoria was similarly afflicted, Alfonso is alleged never to have forgiven Victoria Eugenie nor to have come to terms with what had happened. In all, King Alfonso XIII and Queen Victoria Eugenie had seven children, five sons and two daughters. Neither of their daughters is known to have been a carrier of haemophilia.