Globally, approximately 15% of people are affected by migraine. In the Global Burden of Disease Study of 2010, it was ranked as the third most prevalent disorder in the world. It most often starts at puberty and is worst during middle age. As of 2016, it is one of the most common causes of disability. An early description consistent with migraines is contained in the Ebers papyrus, written around 1500 BC in ancient Egypt. The word "migraine" is from the Greek ἡμικρᾱνίᾱ ("hēmikrāníā"), 'pain in half of the head', from ἡμι- ("hēmi-"), 'half', and κρᾱνίον ("krāníon"), 'skull'.