Fleury started for the Knights during the first round of the 2018 Stanley Cup playoffs. On April 17, 2018, the Golden Knights were able to secure a 4–0 record over the Los Angeles Kings to sweep the first round of playoffs. On May 6, after Fleury posted a shutout, the Golden Knights were able to move on to the Western Conference finals by beating the San Jose Sharks in Game 6 of their playoff series. On May 20, 2018, Fleury led the Golden Knights to a victory over the Winnipeg Jets in the Western Conference Finals, which allowed Fleury to earn a shot at a fourth Stanley Cup.