The first major event held at the facility was a CART series held on Saturday May 24, 1997, the day before the Indy Racing League's Indianapolis 500. Rather than scheduling a race directly opposite the Indy 500 (as they had done in 1996 with the U.S. 500), CART scheduled Gateway the day before to serve as their Memorial Day weekend open-wheel alternative without direct conflict. For 2000, the race was moved to the fall. In 2001, it was dropped from the CART series schedule, and switched alliances to the Indy Racing League. After mediocre attendance, the event was dropped altogether after 2003. It was later re-added to the schedule for 2017.