Opisthoglyphous ("rearward grooves") snakes possess venom injected by a pair of enlarged teeth at the back of the maxillae, which normally angle backward and are grooved to channel venom into the puncture. Since these fangs are not located at the front of the mouth, this arrangement is vernacularly called "rear-fanged". In order to envenomate prey, an opisthoglyphous snake must move the prey into the rear of its mouth and then penetrate it with its fangs, presenting difficulties with large prey although they can quickly move smaller prey into position. The opisthoglyphous dentition appears at least two times in the history of snakes. The venom of some opisthoglyphous snakes is strong enough to harm humans; notably, herpetologists Karl Schmidt and Robert Mertens were killed by a boomslang and a twig snake, respectively, after each underestimated the effects of the bite and failed to seek medical help. Opisthoglyphous snakes are found in the family Colubridae.