The show primarily focused on the day's biggest sports topics and the humorous banter between the Mikes. It acted as the morning show for both the radio and television sides of the production. Outside of a few radio stations that are able to move or decline carriage of the show for their own local morning productions (or for daytime-only operations, may not be able to carry), "Mike & Mike" was effectively a compulsory element of the ESPN Radio schedule, which all affiliates of the network were required to carry.