In July 1968, the 315th Air Division reassigned the 463d Tactical Airlift Wing from Mactan Isle Airfield to Clark AB, and it became a tenant unit under the 405th. The 463d was responsible for operating a C-130 Hercules combat airlift support unit at Tan Son Nhut AB, South Vietnam, and also flew combat support missions within South Vietnam landing and dropping off supplies, equipment and personnel at forward locations throughout the country. It operated three squadrons of C-130s performing rotational deployments to and from Clark, bringing back wounded personnel with aeromedical airlifts, the aircraft returning to South Vietnam filled with combat supplies and equipment. This mission continued until 31 December 1971 when the wing was inactivated as part of the Vietnam drawdown. The 774th Tactical Airlift Squadron remained assigned to the 405th, providing tactical airlift within the Southwest Pacific until 15 September 1972.