North of downtown Buffalo, I-190 follows the eastern edge of the Black Rock Canal (and passes the site of the former Black Rock toll barrier) before rejoining the banks of the Niagara near an exit with the Scajaquada Expressway (NY 198, exit 11). I-190 continues north through the northern extents of Buffalo, meeting multiple streets before separating from the Niagara and interchanging with NY 266 and NY 324 (exits 15 and 16) in quick succession. At exit 16, NY 324 joins I-190 northward through western Tonawanda. The two routes then meet I-290 and NY 266 a second time prior to crossing the Niagara River on the South Grand Island Bridge. NY 324 leaves the expressway shortly after arriving on Grand Island at exit 18.