Blair meets the new doctor in town, Spencer Truman, when Jack needs to have an emergency tracheotomy performed. Blair and Spencer become fast friends, and their friendship helps her deal with Todd's arrest for the murders of Margaret Cochran and their unborn child, which Todd is convicted of and sentenced to prison for in early 2006. She and Todd eventually split over her growing belief that Todd committed the murders. This also strains her relationship with her daughter, Starr, who believes Todd is completely innocent. Spencer and Blair eventually become lovers, but Blair cannot let Todd out of her heart, and is heartbroken when he will not speak to her shortly before his execution. Blair watches as Todd is executed for the murders of Margaret Cochran and their infant son, and is shocked, as is everyone else, to learn that Margaret is alive and well. Blair feels horrible for believing, even for a moment, that Todd had been guilty. Seeing his lifeless body, she begs him to forgive her. With strained expertise, Todd is quickly brought back to life by Spencer, after Detective John McBain, Natalie Vega, and David Vickers bring a very much alive Margart Cochran into the room where the execution was held. Todd refuses to forgive Blair.