MD 25 begins as a one-way pair, Lafayette Street westbound and Lanvale Street eastbound, at the one-way pair comprising MD 2, Calvert Street northbound and St. Paul Street southbound, in the Charles North neighborhood of Baltimore and within the North Central Historic District. Lafayette Street and Lanvale Street head west as two-lane streets and intersects another one-way pair of streets, northbound Charles Street and southbound Maryland Avenue. Within the Charles–Lafayette–Maryland–Lanvale block is a plethora of historic sites: the Hans Schuler Studio and Residence on Lafayette Street, the Charles Theatre and Baltimore City Passenger Railway Power House and Car Barn on Charles Street, and rowhouses comprising the Buildings at 1601–1830 St. Paul Street and 12–20 E. Lafayette Street.