Beginning in 1989, Harris played the title role of a child prodigy doctor in "Doogie Howser, M.D.", for which he was nominated for a Golden Globe. After the show's four-season run ended in 1993, Harris played a number of guest roles on television series, including "Murder, She Wrote". From 1999 to 2000, he starred with Tony Shalhoub in the NBC sitcom "Stark Raving Mad", which lasted 22 episodes. He has played lead roles in a number of made-for-television features including "" in 1994, "My Ántonia" in 1995, "The Christmas Wish" in 1998, "Joan of Arc" in 1999, "The Wedding Dress" in 2001, and "The Christmas Blessing" in 2005.