One of Molina's landmark playoff performances came in Game 7 of the NLCS against the New York Mets, the final game of the series tied at three games each. Starting in the top of the ninth, he batted with a 1–1 score. In the sixth inning, Mets left fielder Endy Chávez had prevented the Cardinals from taking the lead when he leapt to catch Scott Rolen's near-miss home run over the left field fence. This time, however, Molina hit a two-run home run off Aaron Heilman over left field that was too high for Chávez to catch and gave the Cardinals a 3–1 edge.