Following this, the road runs through agricultural areas with some woods and homes, reaching an intersection with PA 841 in the community of Chatham. PA 41 continues through more rural areas and enters Londonderry Township, where it comes to a junction with PA 926. A short distance later, the road reaches a junction with the northern terminus of PA 796. The route runs through more farmland with some woodland and residences, crossing into West Fallowfield Township. Here, PA 41 comes to the community of Cochranville, where it crosses PA 10. After Cochranville, the road heads through more open farmland with some patches of woods and homes. The route climbs a hill, gaining a second northbound lane for trucks, before narrowing back to two lanes and passing to the west of Octorara High School. PA 41 descends a hill, with a second southbound truck lane, before it becomes a two-lane road again. The route briefly passes through a corner of West Sadsbury Township before it enters the borough of Atglen and comes to an intersection with PA 372. Following this, PA 41 heads into wooded areas and comes to a bridge over Amtrak's Keystone Corridor and Swan Road. The road curves northwest and crosses back into West Sadsbury Township, passing through a mix of farm fields and development. The route heads down a hill, with an additional southbound truck lane, before it returns to two lanes.