In 2001, Wilson starred in the national tour of "Leader of the Pack – The Ellie Greenwich Story". A year later, Wilson was appointed by Secretary of State Colin Powell as a "culture-connect ambassador" for the U.S. State Department, appearing at international events arranged by that agency. In 2006, a live concert DVD, "Mary Wilson Live at the Sands", was released. Four years later, another DVD, "Mary Wilson: Live from San Francisco... Up Close", was released. During this period, Wilson became a musical activist, having been part of the Truth in Music Bill, a law proposed to stop impostor groups performing under the names of the 1950s and 1960s rock and roll groups, including Motown groups The Marvelettes and The Supremes. The law was passed in 27 states. Wilson also toured and lectured internationally, as well as across the United States, speaking to multiple groups worldwide. Her lecture series, "Dare to Dream", focuses on reaching goals and triumph over adversity. Wilson's charity work included the Susan G. Komen Race for the Cure, the American Cancer Society, St. Jude's Children's Research Hospital, the Easter Seals Foundation, UNICEF, The NAACP, the Cystic Fibrosis Foundation, the All-Star Network, and Figure Skaters of Harlem, a youth organization devoted to helping children towards entering the Olympics. Most recently, Wilson became the Mine Action spokesperson for the Humpty Dumpty Institute.