The current B61 bus route begins at 20th Street and Prospect Park West at the north end of Green-Wood Cemetery and adjacent to the defunct Bishop Ford Central Catholic High School, straddling the Park Slope, South Slope, and Windsor Terrace neighborhoods. Northbound, the route turns west at 9th Street near New York Methodist Hospital, continuing west through Gowanus and Red Hook via 9th Street, Lorraine Street, and Beard Street (eastbound) or Van Dyke Street (westbound). Much of this routing in Gowanus and Red Hook between Smith Street and the Red Hook IKEA Terminal is shared with the , the only other bus line that travels to and from Red Hook. The B61 then parallels the Crosstown streetcar line, running north on Van Brunt Street (one block west of Richards Street) to Carrol Street near the Red Hook Container Terminal and the Brooklyn Battery Tunnel, then north along Columbia Street and east along Atlantic Avenue into Downtown Brooklyn. The route terminates just south of the Fulton Mall and the Jay Street–MetroTech subway station at Smith Street and Livingston Street, in front of the headquarters of the New York City Transit Authority. Southbound buses reenter service via Boerum Place one block west.