In January 2016, she appeared in Milap Zaveri's adult comedy "Mastizaade", released on January 29, 2016 where she portrayed twin sisters, Laila and Lily Lele along with Tusshar Kapoor and Vir Das. The film released to mixed reviews and was an average earner. One critic said "Leone may not be better than this film, but she's the best thing in it." Her next film was Jasmine D'souza's "One Night Stand" with Tanuj Virwani released on May 6, 2016. The film was released to mixed reviews but was a flop commercially. Her last release of 2016 was Rajeev Chaudary's "Beiimaan Love" opposite Rajneesh Duggal that released on October 14, 2016. Her performance was widely praised but the film met with negative reviews and flopped. She also appeared in song "Tu Zaroorat Nahi Tu Zaroori Hai" with Sharman Joshi in "Fuddu" and item song "Choli Blockbuster" for the film "Dongri Ka Raja". In December 2016, her song "Laila Main Laila" from "Raees" with Shah Rukh Khan was released.