Conventional IELs bear classical TCR receptor made up from α and β subunit together with CD4 or CD8 co-receptors. They represent a relative minority of the total intestinal IELs compared with unconventional IELs. They are derived from naïve T cells that encounter antigens in the periphery (typically antigens displayed by DC in the Peyer´s patches). After this activation, conventional IELs express gut-tropic molecules allowing them to home in intestinal tissue after trafficking through lymph stream and subsequent blood stream. Conventional intraepithelial cells are thus tissue-resident effector memory T cells, capable of rapid respond with cytolytic activity and release of cytokines such as INFγ and TNF.