Byrd and Tim Wakefield started game 4 in a match-up Byrd said might have been "the slowest-throwing right-handed match-up of all time in the post-season". It was also for four innings one of the best pitched match-ups, with both throwing shutouts. However, Casey Blake homered to start the fifth, on the way to the Indians scoring seven runs in one inning for the second time in the series. Boston hitting three straight solo home runs in the sixth closed the gap slightly but not nearly enough and the Indians won 7–3 to take a commanding 3–1 series lead.