During the 15th century portraiture became common, initially often formalised profile portraits but increasingly three-quarter face, bust-length portraits. Patrons of art works such as altarpieces and fresco cycles often were included in the scenes, a notable example being the inclusion of the Sassetti and Medici families in Domenico Ghirlandaio's cycle in the Sassetti Chapel. Portraiture was to become a major subject for High Renaissance painters such as Raphael and Titian and continue into the Mannerist period in works of artists such as Bronzino.