Batting out of the number-five spot in the batting order for the first time in his career on Opening Day, 2007, Molina collected two hits. In a game against the Milwaukee Brewers on April 15, Molina picked Prince Fielder off first base as he leaned far off the bag, tipping off Molina and first baseman Albert Pujols to a hit and run the Brewers were planning. Four days later, Molina faced his brother Bengie for the first time in a game against the San Francisco Giants. It was also the first time they had seen each other in about three and one-half years.