Molina suffered a concussion in September and underwent arthroscopic surgery to repair torn cartilage in his right knee. The knee surgery ended his season early on September 24. In Molina's final 50 games, he successfully collected 49 hits in 158 AB for a .310 AVG. Of his final 35 starts, 12 were multi-hit games. His .281 batting average after the All-Star break ranked fifth among NL catchers. He finished the season with a new career-best .275 batting average, six home runs, and 40 RBIs in 111 games. He threw out 50% (23 of 46) baserunners attempting to steal, the highest percentage in the majors. From 2005–07, he led all MLB with a 47% caught-stealing rate and 18 pick-offs.