In the current routing, Bus. US 223 follows M-52 (Adrian Highway / Main Street) and a former route of US 223 through downtown. The southern terminus is at US 223 at an intersection with M-52 near the southern city line. The business loop runs concurrently with M-52 north into downtown on Main Street, breaking off and running northwesterly along Church Street. From there Bus. US 223 turns westward onto Maumee Street. The route follows Maumee Street to its northern terminus, meeting US 223 again northwest of downtown Adrian.