The two seasons that the series was on the air follow the progress of the Neosapien War, as seen through the eyes of Able Squad, an elite E-frame unit, composed of J.T. Marsh, Nara Burns, Maggie Weston, Kaz Takagi, Alec DeLeon, Rita Torres, Wolf Bronsky, and Marsala. Their exploits unfold against the backdrop of the ongoing war, as the squad participates in events often crucial to turning its tide. The show features a realistic outlook on war: many characters die in combat, military operations are carefully planned and reconnoitered in advance, and psychological effects of warfare are explored. For example, separate episodes detail Exofleet's reconnaissance of Venus prior to its recapture, the actual liberation, and the repulse of the first Neosapien reconquest attempt. Moreover, even after Venus is retaken by Terrans, several episodes deal with the remaining Venusian resistance and Neosapien forces who hid across Venus, refusing to surrender and awaiting reinforcements.