From October 2008 to March 2010 she appeared in the role of Dr. Lily Hassan on the BBC One daytime soap, "Doctors." She portrayed Afia Khan's maternal aunt Shameem on "EastEnders" in 2011. In 2011, Indrani appeared as Brenda Kiely in the Sky1 comedy drama series "The Café". In 2013, she made a guest appearance as DCI Stella Morton in the BBC One drama series "Casualty" in the episode "Badge of Honour". Indrani portrayed Harita in nine episodes of "Catastrophe" in 2015 and 2017.