The western terminus of PA 462 is at a trumpet interchange with US 30 in West Manchester Township, York County, where US 30 heads east on a freeway and west on at-grade West Market Street. From this interchange, PA 462 heads northeast on four-lane divided West Market Street through commercial areas, soon narrowing to a three-lane road with a center left-turn lane. The road passes between industrial areas to the northwest and residential neighborhoods to the southeast before it crosses a York Railway line at-grade. The route runs past businesses and comes to an intersection with the eastern terminus of PA 234. PA 462 narrows to two lanes and heads east past homes, coming to a junction with the western terminus of PA 182 in the community of Kurtz Place. The road enters the borough of West York and is lined with more residences along with a few businesses. Farther east, the route becomes the border between West Manchester Township to the north and West York to the south as it passes to the south of the York Fairgrounds, crossing the York Railway tracks again at-grade. PA 462 continues into the city of York and passes residential and commercial development as a four-lane undivided road, reaching a junction with PA 74.