On 16 May 2016, Prince Mikasa was admitted to the intensive-care unit of St. Luke's International Hospital in Tokyo's Chuo Ward, having contracted acute pneumonia. He remained in hospital for the remaining months of his life. His heart weakened in June, and fluid accumulated in his lungs. Princess Yuriko frequently visited him along with other Imperial family members, including the Emperor and Empress in June. During his last days, Prince Mikasa remained responsive to visitors. On 22 October, Prince Mikasa and his wife celebrated their 75th wedding anniversary in his hospital room. His condition eventually stabilised to the point where he began to receive rehabilitation in his bed, which included stretching his arms and legs. At 7:40 a.m. on 27 October, however, his heart gradually slowed, stopping at 8 a.m. Prince Mikasa was pronounced dead at 8:34 a.m., with his wife at his side. At his death, he had outlived all of his siblings and all three of his sons. He was also the last surviving grandson of Emperor Meiji.