SR 546 continues amid farm country as it enters into Jefferson Township. The highway arcs to the northwest, and passes intersections with Painter Road and Bangorville Road, after which it traverses a more forested terrain for a brief distance before it becomes a blend of woods and open space. SR 546 continues northwesterly as it crosses Clever Road, and passes into Perty Township. It is abutted by a row of houses as it approaches the Black Road T-intersection. and then crosses Darlington East Road. The houses then spread out more as a wooded landscape takes shape as SR 546 approaches the point where Interstate 71 (I-71) goes over the state highway without a direct connection between the two. SR 546 meets Steele Road immediately prior to crossing underneath the Interstate, and then Woodberry Road just after doing so. A balance of woods and farmland appears alongside the state route northwest of I-71, as it passes Coursen Road. After turning to the north, it meets the western leg of Bellville-Jonesville Road, crosses over the Clear Fork of the Mohican River, and then passes by the eastern leg of Bellville-Jonesville Road, immediately followed by Baughman Road. Bending to the north-northwest, SR 546 next meets Mock Road, then curves back to the north prior to intersecting Eckert Road.