In 2015, Kwelagobe signed an open letter which the ONE Campaign had been collecting signatures for; the letter was addressed to Angela Merkel and Nkosazana Dlamini-Zuma, urging them to focus on women as they serve as the head of the G7 in Germany and the AU in South Africa respectively. Kwelagobe sits on the board of the African Institute for Mathematical Sciences, a pan-African network of Centers of Excellence in mathematical sciences founded by 2008 TED Prize winner and quantum physicist, Professor Neil Turok.