Blacksad and Weekly travel to New Orleans to meet Faust LaChapelle (a goat), a failed musician who found success signing more talented yet less fortunate musicians to record labels. They learn that LaChapelle has terminal cancer, and is being treated by Ms. Gibraltar, a "vodou" priestess. LaChapelle begs Blacksad to find Sebastian "Little Hand" Fletcher (a Boxer), who – despite having one arm smaller than the other – was the most successful musician he ever signed. Fletcher has gone missing, and LaChapelle is concerned that his addiction to heroin has something to do with it. Blacksad and Weekly accept the case.