His biggest achievement has been winning the 2009 US Open, defeating Rafael Nadal in the semifinal and 5-time defending champion Roger Federer in the final. He was the first to defeat both Federer and Nadal during the same major and was the only man outside the Big Four to win a major between the 2005 Australian Open and the 2014 Australian Open, a span of 35 tournaments. He is also the second Argentine and the fifth-youngest man to win the US Open in the Open Era. Other career highlights include reaching the 2018 US Open final, winning the bronze medal in men's singles at the 2012 London Olympics, the silver medal at the 2016 Rio Olympics, the Indian Wells Masters in 2018, and being part of his country's successful Davis Cup team; but his career has also been hampered by a succession of wrist and knee injuries.