Maryland Route 313 (MD 313) is a state highway located on the Eastern Shore of Maryland in the United States. The route runs from U.S. Route 50 (US 50) in Mardela Springs, Wicomico County north to MD 213 and MD 290 in Galena, Kent County. It is predominantly a rural two-lane road that runs through agricultural areas a short distance west of the Delaware border, with the exception of a four-lane divided bypass of Denton that is concurrent with MD 404. MD 313 serves many communities, including Sharptown, Eldorado, Federalsburg, Denton, Greensboro, Goldsboro, Barclay, Sudlersville, Millington, and Massey. The route intersects many major roads, including MD 54 in Mardela Springs, MD 404 in the Denton area, MD 302 in Barclay, MD 300 in Sudlersville, and US 301 near Massey.