The highway begins at a T-intersection with SR 13 at a point approximately north of Fredericktown in Middlebury Township. The majority of SR 546 passes through rural terrain, traveling amid vast farmland with a number of homes and the occasional patch of trees appearing alongside the highway. SR 546 departs from SR 13 heading to the northwest, passing its intersection with Yankee Street (County Road 55) before turning north at the Shafer Road intersection. It then crosses Gregg Road before meeting Leedy Road, where the highway crosses into Richland County.