In 2009–10, Granger led the Pacers with 24.1 points per game, eighth best in the NBA and third best in the Eastern Conference. He scored 20 or more points in 45 of 62 appearances and scored 30+ points 16 times. He tallied a career-high 44 points against the Utah Jazz on March 26, 2010. He missed a total of 18 games due to injury or illness, including 16 straight in December and January with a torn plantar fascia in his right foot.