Del Potro reached the round of 16 at Wimbledon for the first time by defeating Flavio Cipolla, Olivier Rochus, and Gilles Simon. He then lost to world No. 1 Rafael Nadal, in four sets, in the fourth round. Del Potro returned to the top 20 at world No. 19 for the first time in nearly a year. His next tournament was the Farmers Classic in Los Angeles, where he received a first-round bye as the second seed. He defeated James Blake but was defeated by Ernests Gulbis in the quarterfinals.