The play is set in Syracuse and the surrounding countryside. Venus, on her way to Syracuse to humble the pride of Queen Sapho, endows a young ferryman named Phao with great beauty. (In some of the myths, Phaon is an old ferryman of Lesbos who is rewarded by Aphrodite with renewed youth and beauty after he transports her from Mytilene to Chios.) The beautiful waiting women of Sapho's court learn of Phao, flirt with and court him; but he is disdainful of them. When Sapho catches sight of Phao she instantly falls in love with him; and Phao in turn is love-struck with her. Sapho hides her infatuation by pretending to be fever-stricken, and sends for Phao, since he reportedly possesses febrifugic herbs. They share a mutual passion, but the enormous gap between their social positions is an insuperable barrier.