The high school is known in the region for its successful music program, including its competitive marching band. The Blackstone-Millville Regional High School Chargers Marching Band has traveled throughout North America for a variety of national competitions and parades, including the National Cherry Blossom Festival, the Rose Parade, and the Macy's Thanksgiving Day Parade. In 2000 and 2001, they won 1st place at the United States Scholastic Band Association national finals in their division, led by then-drum major Nadiene Jacques. On April 7, 2013, the Blackstone-Millville Winter Percussion Ensemble won first place in their division at the New England Scholastic Band Association winter percussion finals. Additionally, in November 2015 the marching band took first place in the Division 4 Open USBands National Championship in East Rutherford, New Jersey.