In 2016, Page co-starred in the Netflix film "Tallulah" as the titular character; the film marked his third collaboration with director Sian Heder, with whom he also worked on "Juno". In the film, his character is a young woman who abducts a baby and tries to pass it off as her own. He received praise for his performance, with "The Guardian" writing "...what grounds it are the terrific performances and Heder's rich direction and screenplay". In the same year, he had voice roles in the films "Window Horses" and "My Life as a Zucchini", the latter of which earned critical acclaim. On November 9, 2017, it was announced that Page had been cast in the main role of Vanya Hargreeves in the Netflix series "The Umbrella Academy". The show received positive reviews from critics, and Page was praised for his performance, earning a Saturn Award nomination in 2019. The series was renewed for a second season in 2019, which was released in 2020. After Page came out as transgender, it was revealed that he would continue his role as Vanya in the show, with Netflix updating Page's name across the service. In the same year, he starred in the critically panned film "Flatliners", a remake of the 1990 film of the same name, and produced and starred in the film "The Cured".