Taliaferro became commander of Virginia's state militia following Virginia's secession action on April 17, 1861; indeed, in what might be Virginia's 1st act of aggression of the war, on April 18, 1861, Virginia State Militia Major General Taliaferro was sent to take command at Norfolk, Virginia. Later he took command of the 23rd Virginia Infantry as a colonel. He fought several engagements in 1861 and by the end of the year had ascended to brigade command, where he led Confederate forces at the Battle of Greenbrier River, in what is now West Virginia.