After the withdrawal from Kentucky, they saw heavy action at the Battle of Shiloh, where the battery was completely overrun despite the men's best efforts to save the guns. Confederate infantry soon recovered the guns and the battery later supported Daniel Ruggles' assault on the "Hornet's Nest" as part of Ruggles' Grand Battery. Even after the bloody fight at Shiloh and the loss of many men, Byrne's Battery continued to serve heroically and effectively in the Orphan Brigade. They participated in every battle of the Orphan Brigade up to Stones River, where they gallantly and defiantly stood to their guns despite overwhelming enemy fire. One gunner lost his hand to an enemy round, but still stayed at his post. Because of its tremendous losses at Stones River, Byrne's Battery was forced to disband and disperse itself amongst the other Kentucky units and even units outside the Orhan Brigade, although though most were simply directly transferred to Lyon's (Cobb's) Battery.