Three songs from "The Sufferer & the Witness" were released as singles: "Ready to Fall", "Prayer of the Refugee", and "The Good Left Undone". All three songs charted on the Modern Rock Tracks chart in the United States, and accompanying music videos were produced. Rise Against supported the album with The Sufferer & the Witness Tour throughout the second half of 2006 and all of 2007. During the tour, guitarist Chris Chasse left the band and was replaced by Zach Blair.