On January 14, 2008, Molina and the Cardinals agreed to a four-year, $15.5 million deal with a club option for a fifth, cementing his position as their starting catcher. He reported to spring training having lost 15 pounds and in improved physical shape from rehabilitating following knee surgery. He started the season with an Opening Day home run and seven-game hitting streak. After a home plate collision with Eric Bruntlett on June 15 against the Philadelphia Phillies in the ninth inning, Molina sustained head and neck injuries and was removed from the field on a stretcher. There were no indications of a concussion. He held on to the ball to help the Cardinals win. He missed the next four games. To that point, Molina was batting .295 with three home runs and 24 RBIs. He also had thrown out 10 of 32 baserunners (31.3%) – well below his career average of 45% – but an Associated Press reporter attributed the decline to an inexperienced pitching staff.