SR 69 begins at the Hovey Lake Fish and Wildlife Area in southwestern Posey County, near the confluence of the Ohio River and the Wabash River. It proceeds roughly northeast as a rural two-lane on the banks of the Hovey Lake. The road turns due north, away from the lake, and towards Mount Vernon. The highway turn northwest passing around the southwest side of Mount Vernon, as a two-lane highway passing through farmland. The road turns east onto SR 62 and the two routes pass through downtown Mount Vernon. On the east side of downtown the road becomes a four-lane divided highway. Soon after SR 69 leaves the divided highway heading north. The route heads away from SR 62, as a four-lane undivided highway. The highway narrows to a two-lane highway and has a crossing with the Evansville Western Railroad track.