PA 41 serves as part of the main route connecting Wilmington to Lancaster and sees heavy truck traffic. Because the route is two lanes wide and carries high levels of local and through traffic, it experiences a high accident rate. Portions of PA 41 prone to aggressive driving have white dots painted along the travel lanes in order to reduce tailgating by telling motorists to keep a minimum of two dots from the vehicle in front of them. In 2015, PA 41 had an annual average daily traffic count ranging from a high of 14,000 vehicles between the Delaware border and US 1 and between PA 796 and PA 10 to a low of 9,100 vehicles between PA 926 and PA 796. The entire length of PA 41 is part of the National Highway System.