"Fetus-X" has been published in newspapers, books, and as a webcomic since late 1999. The first "Fetus-X" comics were drawn by artist Casey Sorrow, who later left to create the comic "Feral Calf". The storylines of "Fetus-X" generally revolve around Millikin's use of the occult in both romantic relationships and battles with various ghosts, demons, aliens, and monsters. The artwork is mixed media, combining expressionist paintings with found objects. The text is often written in free verse. Early comics are in black and white, but after 2002 most are full color.