Guice began his career with fanzine work and "designing patches and emblems for a small company in North Carolina." His first credited comics work was penciling and inking the independently published "The Crusaders" #1 (November 1982), although he had previously ghosted for Pat Broderick on "Rom Annual" #1 (1982). On the strength of his fanzine work, (and, Guice believes, at the behest of "Rom Annual" writer Bill Mantlo) Marvel editor Al Milgrom offered him a tryout on the toy-spin-off title "Micronauts". Referring to "Rom Annual" #1 and "Micronauts" #48 (Dec. 1982), he remarked that "oth were breaking points for me getting into comics".