Erlwine noted how influential the guitar play on the album was. " unleashed a torrent of blistering guitar runs that were profoundly influential, not just in blues, but in rock & roll". Journalist Sean McDevitt agreed with this statement, and wrote ""Born Under a Bad Sign" directly influenced legions of guitar players who studied its every subtlety and nuance". Among these guitarists are Eric Clapton, Mike Bloomfield, Jimi Hendrix, and Stevie Ray Vaughan, most of whom covered songs from "Born Under a Bad Sign". Clapton's band Cream sampled the guitar solo from "Oh, Pretty Woman" for the song "Strange Brew", and covered "Born Under a Bad Sign" for their 1968 album "Wheels of Fire". The Paul Butterfield Blues Band also covered "Born Under a Bad Sign" for the 1967 album "The Resurrection of Pigboy Crabshaw".