As a freshman at UIC in 2000, Granderson led the UIC Flames baseball team with seven home runs and 45 walks. He followed that by hitting .304 as a sophomore, leading the team in runs, home runs, and walks. After his sophomore year, Granderson played in a summer collegiate league for the Mankato Mashers, now known as the MoonDogs, of the Northwoods League, where he batted .328 in 44 games, with eight doubles, two triples, one home run, 17 RBI, 28 runs scored, and 15 stolen bases.