Anna is revealed to be alive in March 2001 when her twin-sister Alex (Hughes) returns to her home in Pine Valley to announce that she's been secretly caring for her sister. Months earlier, Alex had been summoned to Canada by Bart (Ralph Waite). Bart had been caring for Anna when she began having seizures. Bart immediately contacts Alex for help. With the help of her brother-in-law Dimitri Marick (Michael Nader) and his brother Edmund Grey (John Callahan), Anna checks into Pine Valley Medical Center, posing as Alex. Alex also enlist her colleague David Hayward (Vincent Irizarry) to heal her sister. While Anna recovers, she has no recollection of her life in Port Charles. Meanwhile, Anna learned from Alex that their aunt Charlotte had put a hit out on her. The failed hit puts claims the life of Gillian Andrassy. Anna settled into her new life and also met her half-brother Gabriel. Charlotte had brainwashed Gabriel to kill Anna but The sisters are able to break the conditioning. In May 2001, Anna shares a happy reunion with Robin. While she wanted to be with Robin, Anna knew she'd put her in danger. Anna turns to the WSB for protection and they partner her up with federal agent Chris Stamp to apprehend the drug lord Proteuos.