After starting middle linebacker Nick Barnett went down with a season-ending wrist injury in Week 4 of the 2010 season, Bishop was quickly named Barnett's replacement and exceeded expectations. He started the remaining 12 games and finished the season with 103 tackles, 3 sacks, 2 forced fumble and 1 interception, which was returned for a touchdown. He was a starter and also recovered a crucial fumble in Super Bowl XLV, after Clay Matthews knocked the ball loose from Rashard Mendenhall, which was a key play in the Packers' 31–25 win over the Pittsburgh Steelers.