Past US 40, the route heads away from the downtown area and passes more rowhomes. It comes to a partial interchange with I-83 (Jones Falls Expressway), consisting of a ramp from southbound I-83 to southbound MD 2, and crosses over Amtrak's Northeast Corridor rail line adjacent to Penn Station serving Amtrak and MARC's Penn Line. Past the train station, MD 2 intersects the southern terminus of MD 25, which follows a one-way pair along eastbound Lanvale Street (carrying the southbound direction) and westbound Lafayette Avenue (carrying the northbound direction), before it comes to its northern terminus at US 1 and US 40 Truck (North Avenue).