I-190 begins at an interchange with the New York State Thruway (I-90) in Cheektowaga in Erie County, just north of the West Seneca town line and east of the Buffalo city line. I-190 heads west into Buffalo, passing the former location of the City Line toll barrier ahead of an interchange with South Ogden Street (exit 1). Farther west, I-190 meets NY 354 (exit 2), NY 16 (exit 3), and several local streets before entering downtown Buffalo. Within the downtown area, I-190 passes between KeyBank Center and Sahlen Field near an interchange with NY 5 (exit 7) on the shores of Lake Erie. At NY 5, I-190 turns northward to follow the path of the Niagara River. Shortly after meeting NY 266 (exit 8) immediately northwest of downtown, I-190 interchanges with Porter Avenue (exit 9), a local roadway connecting I-190 to the Peace Bridge and, thus, the Queen Elizabeth Way in Canada.