Hernández faced the Rangers on September 17, 2010 and was working on a no-hitter until Nelson Cruz broke it up with a home run in the eighth inning. In his next start, he threw a complete game two-hitter in Toronto, surrendering only one run on José Bautista's 50th home run of the year in the first inning. The Mariners offense, however, was shut out by Blue Jays pitching and Hernández was dealt his twelfth loss of the season. Ten of Hernández's twelve losses were in games where the Mariners were shut out or scored only one run, and four other times, the bullpen blew a lead Hernandez turned over to them.