Since 2005, Parker has been an active donor to cancer research, global public health and civic engagement. In 2012, he pledged a $5 million grant to Stand Up to Cancer and the Cancer Research Institute to create the Immunotherapy Dream Team, uniting laboratory and clinical efforts that will lead to the immunological treatment, control and prevention of cancer. In December 2014, Parker pledged $24 million to create the Sean N. Parker Center for Allergy Research at Stanford. In 2015, he made a $4.5 million grant to support the Malaria Elimination Initiative at the University of California San Francisco's Global Health Group, and a $10 million grant to create the Sean N. Parker Autoimmune Research Laboratory at UCSF.