A sore left knee sustained after taking a foul ball of his kneecap temporarily disabled Molina on September 26. He was back in action on October 1 against Cincinnati, although he was removed from that game due to a "tweaked" knee. He finished the season with a .293 batting average, six home runs, 54 RBIs, and a major league-leading 136 games caught, the highest franchise total since Ted Simmons' total in 1977. His strikeout rate of once every 13.9 PA was the second-lowest in the NL. While accumulating 39 mult-hit games, the Cardinals won 27 of them. He led the major leagues with eight pickoffs and was second in the NL in innings caught. He also won his second Gold Glove award after the season. "The Sporting News" announced that major league managers and coaches had selected Molina for the magazine's end-of-season All-Star award. For the first time in his career, Molina earned Most Valuable Player Award (MVP) consideration. He finished tied for 23rd with Miguel Tejada with one percent of the vote share.