In the manga series "Pokémon Adventures", Team Rocket created Mewtwo, but some of its DNA is placed inside the Gym leader Blaine. Because of the DNA that they share, the two are unable to be separated for very long without becoming ill. Later, another Pokémon, Entei, is able to break the bond between the two by removing the DNA in Blaine's arm, at which point Mewtwo leaves. It eventually helps the main character of the series, Red, fight against Team Rocket leader Giovanni and his Deoxys.