Scipione received many honours from his uncle. He became superintendent general of the Papal States, legate in Avignon, archpriest of the Lateran and Vatican basilicas, prefect of the Signature of Grace, Abbot of Subiaco and San Gregorio da Sassola on the Coelian, and librarian of the Roman Catholic Church. He also assumed the offices of Grand Penitentiary, secretary of the Apostolic Briefs, Archbishop of Bologna, protector of Germany and the Habsburg Netherlands, of the Orders of Dominicans, Camaldolese and Olivetans, of the Shrine of Loreto and of the Swiss Guard, and numerous other ecclesiastical positions. In each of these offices the cardinal received stipends. His income in 1609 was about 90,000 scudi, and by 1612 it had reached 140,000 scudi. With his enormous wealth, he bought the villages of Montefortino and Olevano Romano from Pier Francesco Colonna, Duke of Zagarolo for 280,000 scudi.