Ignashevich came out of international retirement prior to the 2018 FIFA World Cup as he was called up on 14 May 2018 to replace injured Ruslan Kambolov. On 3 June 2018, he was included in the finalized World Cup squad. Against Spain in the Round of Sixteen, he scored an own-goal while tangling with Sergio Ramos during a corner set-piece, but Russia would equalize thanks to a penalty, and in the shoot-out Ignashevich converted his spot kick to help Russia advance. Following Russia's elimination in the 2018 FIFA World Cup quarterfinal against Croatia after extra time ended deadlocked 2–2, where he successfully converted a shoot-out kick, Ignashevich announced his retirement from all forms of football.