Nespoli contributed to the scientific exploitation of Europe's "Columbus" laboratory. As an astronaut, he carried out several experiments for ESA, NASA and also the Japanese and Canadian space agencies. During the mission, Paolo participated in some educational activities: the educational programme "Mission X: Train Like an Astronaut" which gave children the chance to follow an international initiative built around health, well-being and nutrition. He also participated in a greenhouse activity in space. Nespoli used ESA's novel 3D camera to show images of the ISS.