Along with the Cholokashvili and Abashidze families, the Andronikashvili were regarded as grandees of the first class of the Kingdom of Kakheti. They held key political, diplomatic and military posts at the court and were distinguished for their particular loyalty to the royal Bagrationi dynasty with which they had ties of marriage. In the 1780s, they functioned as military governors of Ganja Khanate which was briefly subjugated by King Erekle II to Georgian control. Several representatives of the family served also as bishops of Bodbe, Ninotsminda, Alaverdi and Nekresi.