Knoxville, Georgia was established on the Federal Road, the main stagecoach route from Washington, D.C., to New Orleans, making the town a natural choice for county seat. Although the chief center of population is now Roberta, a mile to its west, Knoxville (no longer an incorporated city) retains its designation as the county seat. The current courthouse, built there in 2002, replaced one built in 1851, which still stands. The Old Courthouse is designated as a historical site and is used as a museum.