US 223 returns to a due west track as it crosses a branch of the Norfolk Southern Railway, and the roadway approaches the outskirts of Adrian. The highway runs along the southern city limits for Adrian as it meets M-52. The only business loop for US 223 runs north of this intersection with M-52 into downtown Adrian while US 223 continues through a secondary business corridor south and west of town. US 223 crosses Beaver Creek and then intersects M-34 on the western city line in a residential section of Adrian. As US 223 crosses fully into the city of Adrian, it continues northwesterly, then turns due west at the intersection where it meets its business loop's western terminus. Outside of town, the highway crosses through more farmland continuing to northwestern Lenawee County.