Knight painted throughout her life but did not start seriously exhibiting her work until the 1970s. Her first retrospective was put on when she was nearly 90 years old, "Never Late for Heaven: The Art of Gwen Knight," at the Tacoma Art Museum in 2003. Her teachers in the arts included the sculptor Augusta Savage (who obtained support for her from the Works Progress Administration) and Jacob Lawrence, whom she married in 1941 and remained married to until his death in 2000. During the course of her career, she received many awards, including the National Honor Award, and two honorary doctorate degrees, from University of Minnesota and Seattle University.