Just past the MD 260 intersection, MD 2 crosses into Anne Arundel County where it continues through a mix of farmland and woodland. It intersects Friendship Road/Sansbury Road at a roundabout, which connects to MD 261, before intersecting MD 778 again. The route junctions with MD 423 (Fairhaven Road). The road proceeds through rural areas with some residences, coming to an intersection with MD 256 (Deale Road). A short distance later, MD 2 crosses MD 258 (Bay Front Road) and passes east of a park and ride lot as it continues north, with former alignments of the road designated as suffixed segments of MD 778. The road reaches Lothian, where it intersects MD 408 (Mount Zion-Marlboro Road) and MD 422 (Bayard Road) at a roundabout.