Born in Leipzig, Walcha was blinded at age 19 after vaccination for smallpox. Despite his disability, he entered the Leipzig Conservatory and became an assistant at the Thomaskirche to Günther Ramin, who was professor of organ at the conservatory and cantor at St. Thomas'. In 1929, Walcha accepted a position in Frankfurt am Main at the Friedenskirche and remained in Frankfurt for the rest of his life. From 1933 to 1938 he taught at the Hoch Conservatory. In 1938 he was appointed professor of organ at the Musikhochschule in Frankfurt and organist of the Dreikönigskirche in 1946. He retired from public performance in 1981 and died in Frankfurt.