Both the album and the song proved major successes for Sinatra. The song was a number-four hit on the US "Billboard" Hot 100 chart and reached number one on the Easy Listening chart for three weeks in December 1966/January 1967. In Canada, the song reached number three. Sinatra's cover of "That's Life" was later used in the 1993 film "A Bronx Tale" alongside his recording of "Same Old Song and Dance". It was also featured in the 2004 video game "Tony Hawk's Underground 2". The song was also in the 1988 film "License to Drive", a scene where the main character puts clown makeup on and the final scene of the 2019 film "Joker", and during the final scene of the final episode of the sixth season of the NBC television comedy series "Brooklyn Nine-Nine".