The current routing of Bus. US 223 marks the second time the designation has been used in the Adrian area. The first was created in 1942 when the first bypass of Adrian was constructed. This bypass was built along Cadmus Road at Treat Highway west to M-52 (Adrian Highway). US 223 then ran along M-52 to connect with the previous routing. Bus. US 223 was designated along Church, Center, Beecher and Treat streets, the former routing of US 223 through downtown. This incarnation of Bus. US 223 would survive until March 26, 1956 when another new bypass of Adrian was built. The first Bus. US 223 was deleted to allow the designation to be used on the routing of the first US 223 bypass. This first bypass became the current alignment of Bus. US 223.