John's French wife, Duchess Anne had died at Saint-Saturnin in June 1524. This was soon after their only daughter, Anne Stewart (Anne de Stuart d'Auvergne) had died in her teens and without any children of her own. Duchess Anne left her inheritance in Auvergne to her infant niece, Catherine de' Medici (b. 1519), daughter of John's first cousin and Anne's younger sister the late Madeleine of Auvergne, and Lorenzo, Duke of Urbino. Catherine, or rather her guardians in France, thus received the county of Auvergne.