Karpyshyn joined the video game company BioWare in 2000. He wrote the scenario and much of the dialogue for "", for which he would share the award for "Excellence in Writing" at the 2003 Game Developers Choice Awards. He was later one of the lead writers and planners on "Jade Empire", and worked on several games in the "Baldur's Gate" series. His next major project was the "Mass Effect" series of games. His third book, "Darth Bane: Path of Destruction" was published by Del Rey Ballantine Books in 2006.