After 1827 Cole maintained a studio at the farm called Cedar Grove, in the town of Catskill, New York. He painted a significant portion of his work in this studio. In 1836, he married Maria Bartow of Catskill, a niece of the owner's, and became a year-round resident. Thomas and Maria had five children. Cole's daughter Emily was a botanical artist who worked in watercolor and painted porcelain. Cole's sister, Sarah Cole, was also a landscape painter; the two were close.