Del Potro defeated Feliciano López before losing to eventual semifinalist Mardy Fish in the second round of the indoor Regions Morgan Keegan Championships. In his next ATP Masters event, he reached the second round of the Pacific Life Open, beating Gustavo Kuerten in the first round, but then losing to Richard Gasquet. Del Potro went further in the Sony Ericsson Open, reaching the fourth round, after he defeated three top-50 players: Jonas Björkman, Marcos Baghdatis, and Mikhail Youzhny, before falling to Rafael Nadal in two sets. In May, he lost in the first round of the French Open to eventual champion Nadal.