In 1941, Trimble married Marian Constance Blackton, a daughter of J. Stuart Blackton, one of the founders of Vitagraph Studios. In her personal biography of her father, Marian Blackton Trimble recalled watching Trimble work with Jean on location in 1909: "If any member of the company had stepped out of the group that sunny morning and pointing a finger first at Larry Trimble and then at the producer's scrawny, eight-year-old daughter and said, 'These two will be married one day,' we would have thought it the prophecy of a lunatic. For myself I would have protested hotly that I would never marry a man with red hair." "It was a second marriage for them both," wrote film historian Anthony Slide, "a loving and constant relationship."