Brohm injured his thumb in Louisville's September 16, 2006 victory over Miami (FL). He returned as starting quarterback in Louisville's October 14, 2006 victory against Cincinnati. He had been replaced at starting quarterback by sophomore backup Hunter Cantwell for the previous two games. Before his injury, Brohm was one of two candidates at U of L for the 2006 Heisman Trophy, along with senior running back Michael Bush. The pair, both born and raised in Louisville, were dubbed "The Derby City Duo."