At the start of the 2010 year, Puebla along with Club América, Monterrey, Chiapas, Estudiantes Tecos, Club Santos Laguna, Tigres de la UANL and Atlante played the 2010 InterLiga. Puebla finished first in group B with 2 wins no draws and 1 loss, scored 6 goals and allowed 3 for a total of 6 points. The club qualified for the final in which they faced group A second place which was Estudiantes Tecos. That match took place on 13 January 2010 played in front of 27,000 in The Home Depot Center. Puebla's Alejandro Acosta scored the first goal in the fourth minute of play followed by Nicolás Olivera goal in the 47'. In the second half Estudiantes Tecos scored 3 consecutive goals and so qualifying to the 2010 Copa Libertadores.