During early Ottoman rule in Palestine, the revenues of the village of Qaqun were in 1557 designated for the new waqf of Hasseki Sultan Imaret in Jerusalem, established by Hasseki Hurrem Sultan (Roxelana), the wife of Suleiman the Magnificent. By 1596, Qaqun was the center of the "nahiya" (subdistrict) of Qaqun under Nablus Sanjak with a population of 19 households and 4 bachelors; an estimated 127 persons; all Muslim. They paid a fixed tax rate of 25% on a number of crops, including wheat and barley, as well as on goats and beehives; a total of 16,590 akçe.