After beginning his career as a comedian and later becoming an MTV presenter, Brand first achieved renown in 2004 as the host of "Big Brother's Big Mouth", a "Big Brother" spin-off. In 2007, he had his first major film role in "St Trinian's", and the following year he landed a major role in the romantic comedy-drama "Forgetting Sarah Marshall"; the film led to him starring in a spin off, the rock comedy "Get Him to the Greek", alongside Jonah Hill in 2010. He also worked as a voice actor in the animated films "Despicable Me" in 2010, "Hop" in 2011, and "Despicable Me 2" in 2013, and played the title character of the 2011 remake of the romantic comedy "Arthur". In 2013, he released the successful stand-up special "Messiah Complex".