At the southern end of the Hampden neighborhood to the east and the Woodberry community on the western hills, MD 25 ascends from the Jones Falls valley and temporarily expands to a four-lane divided street at its ramps with I-83 (Jones Falls Expressway). The partial interchange, which includes ramps from southbound MD 25 to southbound I-83 and from northbound I-83 to northbound MD 25, is next to the historic home "Evergreen on the Falls" now occupied by the Maryland association of the Society for the Prevention of Cruelty to Animals (SPCA). The street becomes undivided and reduces to two lanes at the main street of Hampden, 36th Street or The Avenue. North of 41st Street, MD 25 passes between the neighborhoods of Medfield to the west and Hoes Heights on the east. The highway intersects Cold Spring Lane next to the joint campus of the Baltimore Polytechnic Institute (Baltimore City public high school specializing in math, science, engineering and technology) and the all-girls Western High School and passes between the Village of Cross Keys (an apartment-condo complex with a small shopping center/mall) on the west and the community of Roland Park on the hills above to the east as a four-lane undivided highway. MD 25 intersects Northern Parkway, (built over and segmented with former Belvedere Avenue) then descends again into the Jones Falls valley and passes through the center of Mount Washington. The neighborhood contains the North Baltimore Aquatic Club, where American Olympics team member Michael Phelps trained, and an intersection with Kelly Avenue and its Bridge which connects to the west with the hilly community of Mount Washington, where the highway reduces to two lanes. Here also is the former campus of old Mount Saint Agnes College for women, and its famous "Octagon House", now a corporate campus for several financial and insurance companies), MD 25 leaves the city of Baltimore at its 1919 City Limits just south of West Lake Avenue.