Pike's first marriage to Jane Alvies ended in divorce in 1941, although Pike claimed it had been annulled. He married Esther Yanovsky in 1942; they had four children, two boys and two girls. Before his second wife filed for divorce in 1965, Pike had been living openly with his secretary, Maren Hackett Bergrud, until her suicide in 1967 at age 43, when she took an overdose of sleeping pills in his apartment after they had an argument. Pike officiated at her funeral.