Mr. Lady Records folded, and the group switched to Universal Records for the 2004 release of "This Island". Hanna left the band in 2005 due to illness; she was later diagnosed with late stage Lyme disease. According to the Le Tigre website, during her time off from the band, Hanna volunteered as a band coach for the Willie Mae Rock and Roll Camp for Girls. She also taught an art class at NYU's grad school in the Fall 2007 semester and attended interior design classes. In 2010, Hanna DJed at the Museum of Modern Art, later joining the Raincoats on stage to cover the Slits' "Vindictive".