Krul made his Premier League debut for Newcastle on 18 September 2010 against Everton at Goodison Park, coming on as a substitute in the 35th minute for the injured Steve Harper in a match that ended in a 1–0 win for the Magpies. He made his first Premier League start on 26 September against Stoke City at St James' Park. He then played against Manchester City in a 2–1 loss, Wigan Athletic in a 2–2 draw and in the 2–1 away win to West Ham United, before starting in his first Tyne-Wear derby, Newcastle winning 5–1, and a 1–0 away win at Arsenal a week later.