Aside from the tremendous contribution of the rail system to Millis' integration with the major Massachusetts cities, another important moment in the town's history is the construction of the Hartford and Dedham Turnpike, known today as Massachusetts Route 109. The road was constructed in 1806 and officially accepted by the town of Millis in 1896. The Hartford and Dedham Turnpike connected Millis, Medway, Medfield, and several other towns directly to Dedham and Boston. Today, Route 109 still serves as a major road connecting Metrowest Boston communities to the city of Boston.