Del Potro continued his impressive run at the Miami Open, again starting from the second round as a seeded player. He defeated Robin Haase, 26th seed Kei Nishikori and 22nd seed Filip Krajinović, before facing off in the quarterfinals against 20th seed Milos Raonic in a rematch of their previous duel. Delpo managed to once again prevail in a grueling match against the Canadian, reaching the semifinals. His streak finally ended as he was defeated by 14th seed and eventual champion John Isner.