In 2000, Amerson was used heavily as a receiver and kick returner, recording 70 receptions for 1,198 receiving yards and six touchdowns as well as 948 return yards over 51 kick returns, all career-highs at the time. In a July game against the Saskatchewan Roughriders, Amerson caught a 74-yard touchdown pass in the eventual 40–34 win. He followed this up with five catches for 180 yards and two touchdowns the next month when the Tiger-Cats played the Roughriders again. Following this, Amerson was named player of the week and described by "The Hamilton Spectator" as both halves of "Hamilton's one-two punch". In September, Amerson caught a 75-yard touchdown pass to help the Tiger-Cats defeat the Alouettes 15–9.