Edward de Vere was born heir to the second oldest earldom in England, at the de Vere ancestral home, Hedingham Castle, in Essex, north-east of London. He was the only son of John de Vere, 16th Earl of Oxford, and his second wife, Margery Golding and was probably named to honour Edward VI, from whom he received a gilded christening cup. He had an older half-sister, Katherine, the child of his father's first marriage to Dorothy Neville, and a younger sister, Mary de Vere. Both his parents had established court connections: the 16th Earl accompanying Princess Elizabeth from her house arrest at Hatfield to the throne, and the countess being appointed a maid of honour in 1559.