The elevation near the mouth of Wyoming Creek is above sea level. The elevation of the creek's source is between . Between above sea level (river mile 25.5) and above sea level (river mile 3.5), the creek's elevation decreases at a rate of per mile. The highest elevation in the watershed is approximately above sea level, on North Mountain. The lowest elevation is approximately above sea level, near the Susquehanna River. Many of the highest elevations occur in the western and southwestern parts of the creek's watershed.