In January 2008 the results of a study using neuroimaging were published. To provide what are purported to be the most favorable experimental conditions, the study included appropriate emotional stimuli and had participants who are biologically or emotionally related, such as twins. The experiment was designed to produce positive results if telepathy, clairvoyance or precognition occurred, but despite this no distinguishable neuronal responses were found between psychic stimuli and non-psychic stimuli, while variations in the same stimuli showed anticipated effects on patterns of brain activation. The researchers concluded that "These findings are the strongest evidence yet obtained against the existence of paranormal mental phenomena." Other studies have attempted to test the psi hypothesis by using functional neuroimaging. A neuroscience review of the studies (Acunzo "et al". 2013) discovered methodological weaknesses that could account for the reported psi effects.