Charles Neale (1751–1823) was a leader of the Jesuit mission in America. He was born in the Catholic colony of Maryland to a prominent family, descended from Captain James Neale, who had settled in the colony in 1642 with a royal grant of land of two thousand acres. The family traced its origins to the noble O'Neill family of Ireland, from whom came the kings of Ulster. Among his direct descendants were Roswell Neale (grandfather to Charles) and his brother, Father Bennett Neale, S.J., one of the first Jesuits in the English colony.