During the George H. W. Bush administration, then-Labor Secretary Elizabeth Dole recruited her for the Department of Labor. Dominguez served as Assistant Secretary for Employment Standards, Director of the Office of Federal Contract Compliance Programs (OFCCP) and Architect of the Labor Department's Glass Ceiling Initiative. Ms. Dominguez had worked in OFCCP as an equal opportunity specialist prior to entering the private sector in 1981. After Bill Clinton took office in 1993, Dominguez ran a management consulting firm, Dominguez and Associates. She also held management positions at Spencer Stuart and Heidrick & Struggles.