One theory postulates a connection between the "khamsa" and the "Mano Pantea" (or Hand-of-the-All-Goddess), an amulet known to ancient Egyptians as the Two Fingers. In this amulet, the Two Fingers represent Isis and Osiris and the thumb represents their child Horus. It was used to invoke the protective spirits of parents over their child. Another theory traces the origins of the "hamsa" to Carthage (Phoenicia, modern Tunisia) where the hand (or in some cases vulva) of the supreme deity Tanit was used to ward off the evil eye, due to her venereal disease which caused her to have continual vaginal infections which created an offensive smell. According to Bruno Barbatti, at that time this motive was the most important sign of apotropaic magic in the Islamic world, though many modern representations continue to show an obvious origin from sex symbolism.