Karen Silkwood, a worker at the Kerr-McGee Cimarron Fuel Fabrication Site (near Crescent, Oklahoma), shares a ramshackle house with two co-workers, her boyfriend Drew Stephens and her lesbian friend Dolly Pelliker. She makes MOX fuel rods for nuclear reactors, where she deals with the threat of exposure to radiation. She has become a union activist, concerned that corporate practices may adversely affect the health of workers. She is also engaged in a conflict with her former common-law husband in an effort to have more time with their three children.