In a series of Doctor Kildare movies in the 1930s and 1940s, he played the irascible Doctor Gillespie, a role he repeated in an MGM radio series that debuted in New York in 1950 and was later syndicated. Barrymore had broken his hip in an accident, hence he played Gillespie in a wheelchair. Later, his worsening arthritis kept him in the chair. The injury also precluded his playing Ebenezer Scrooge in the 1938 MGM film version of "A Christmas Carol", a role Barrymore played every year but two (replaced by brother John Barrymore in 1936 and replaced by Orson Welles in 1938) on the radio from 1934 through 1953. He also played the title role in the 1940s radio series, "Mayor of the Town".