After finishing her reign as Miss Universe, Kwelagobe enrolled in Columbia University and graduated with a degree in international political economy. In 2000, Kwelagobe was made a goodwill ambassador by the United Nations, focusing on youth and HIV/AIDS. She addressed the World Summit on Sustainable Development, the Least Developed Countries conference, the World Youth Summit, and the United States House Committee on Financial Services regarding the HIV/AIDS epidemic. Kwelagobe testified on the socioeconomic impact of HIV/AIDS in Africa and proposed a bill to set up a World Bank AIDS prevention trust fund.