Fresh off a victory the night before, the White Sox tried to make it two in a row in the Series, but this time the opposing pitcher was Andy Pettitte, an excellent pitcher who was making his 34th career postseason start. This game was sloppy, as temperatures were cold and it was raining. Mark Buehrle wasn't throwing his best pitches, as he gave up four runs in seven innings. However, with the White Sox down 4–2 in the seventh, Paul Konerko took over. With the bases loaded, he sent the first pitch he saw from reliever Chad Qualls into the left field bullpen for a 6–4 White Sox lead on a grand slam. The slam was the first one in White Sox postseason history. However, the lead only lasted for an inning. Bobby Jenks, evidently not playing his best either, gave up two runs in the top of the ninth to tie the game. Fortunately enough for Jenks, Scott Podsednik came to the rescue. Hitting second in the ninth, Podsednik sent a pitch from Brad Lidge into the right field seats for a walk-off home run, his first homer of the whole season. It was the 14th walk-off home run in World Series history, and sent the White Sox to Houston up two games to none. Final Score: White Sox 7, Astros 6.