When the regiment deployed to the front line in June 1942, the 588th Night Bomber Regiment became part of the 4th Air Army of the Southern Front. In February 1943 the regiment was honored with the Guards designation and reorganized as the 46th Guards Night Bomber Aviation Regiment in the 325th Night Bomber Aviation Division, 4th Air Army, 2nd Belorussian Front; in October 1943 it became the 46th "Taman" Guards Night Bomber Aviation Regiment, "Taman" referring to the unit's involvement in the Novorossiysk-Taman operations on the Taman Peninsula during 1943.