Chalcone derivatives have demonstrated admirable anti-inflammatory activity due to their inhibitory potential against various therapeutic targets like cyclooxygenase (COX), lipooxygenase (LOX), interleukins (IL), prostaglandins (PGs), nitric oxide synthase (NOS), leukotriene D4 (LTD4), nuclear factor-κB (NFκB), intracellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), monocyte chemoattractant protein-1 (MCP-1), TLR4/MD-2, etc. Indole chalcones may bind and inhibit the KasA protein of "Mycobacterium tuberculosis". Preliminary docking studies indicate that chalcones may inhibit SARS-CoV-2 proteins specifically the main protease (Mpro), RNA dependent RNA polymerase (RdRP) and spike (S) proteins.