CR 506 begins at an intersection with Route 159 in Fairfield Township. The route heads east-southeast as a four-lane divided highway called Bloomfield Avenue, which becomes an undivided road by the first intersection. Just after crossing the town line into West Caldwell, CR 506 becomes a divided highway again, and intersects with local roads as it passes suburban areas of homes and businesses. After the intersection with Distler Avenue, the road briefly becomes undivided. Becoming a divided highway, the route crosses over CR 613 Spur and CR 613. The divided highway ends again as CR 506 turns more to the southeast before coming to CR 633. Prior to this intersection, the road is a divided highway.