While attending a student journalism award ceremony with Jimmy Olsen and Cat Grant, Lana suddenly collapses, with blood pouring out her nose.; She receives a call from her doctor telling her that he has "bad news" for her. After Lana has another collapse, she is taken to the hospital and brought into surgery. She apparently dies on the operating table, but black insect-like creatures later encase her body in a cocoon, which then starts to crack open. A gigantic cocoon-like structure soon engulfs the hospital, and an army of giant insects takes hostage a number of workers as well as the Science Police and the Guardian. Supergirl is soon captured and awakens bound and gagged at the feet of Lana, whom the Insect Queen now possesses. The Queen reveals to Supergirl that during her last encounter with Lana, she injected her with a portion of her DNA and has been slowly taking control of her body for the past year, with the ultimate goal of capturing a Kryptonian to use as a template for an army of hybrid insects. Supergirl breaks free and is able to expel the Queen from Lana's body with help from Kryptonian technology, and Lana returns to her normal state. While Lana is recovering, Supergirl visits her. Supergirl tells Lana she can no longer be a part of her family because of her lies about her condition. Lana and "Linda" have since reconciled and are currently living in the Hammersmith tower building in Metropolis.