Seneca City was developed at the intersection of the Blue Ridge Railroad and the newly built Atlanta and Charlotte Air Line Railroad. Both lines are now part of the Norfolk Southern Railway. A. W. Thompson and J. J. Norton, who were locating engineers for the Air Line Railroad, purchased the land from Col. Brown of Anderson, South Carolina, also in the large Pickens District. A stake marking the center of town was driven into the ground at the intersection of the railroad tracks and the current Townville Street. The land was divided into lots for one-half mile from the stake. An auction was held on August 14, 1873. The town was given a charter by the state legislature on March 14, 1874. In 1908, the name was changed to the shorter Seneca.