North from the Gillespie Gap, NC 226 goes through the Grassy Creek community before entering Spruce Pine. After a short concurrency with US 19E, it continues northwesterly towards Bakersville, passing by and through the communities of Minpro, Penland, Normanville and Ledger. Near Bakersville, the second alternate route breaks-off; NC 226A, along Mine Creek Road, provides a bypass route instead of going through downtown area, reconnecting at Loafers Glory. In Bakersville, NC 226 connects with NC 261, which continues to Roan Mountain. West of Bakersville, NC 226 connects with NC 197, in Red Hill, then goes north to Honeycutt. Following along Big Rock Creek to Buladean, it then goes northwesterly alongside Spring Creek before ascending Iron Mountain. At Iron Mountain Gap (), NC 226 crosses the Appalachian Trail as it enters Tennessee and continues as SR 107 towards Erwin.