On September 1, 2007, Moore led Appalachian State to score one of the biggest upsets in college football history, defeating the then fifth-ranked Michigan Wolverines 34–32 at Michigan Stadium. This marked the first time a team in a lower subdivision defeated a ranked team in a higher subdivision. It was also the first game and loss for Michigan against a Division I FCS team. Moore had learned the spread offensive scheme that enabled him to defeat Michigan from then-West Virginia coach Rich Rodriguez, whom Michigan hired to succeed Lloyd Carr the following season.