In Iowa's first-ever meeting with Ohio State, Locke rushed for 126 yards and returned three kicks for 91 yards as Iowa defeated the Buckeyes in Columbus, 12–9. He also scored both of Iowa's touchdowns. In Locke's final collegiate game against Northwestern, he scored four touchdowns for the third time in his career, leading Iowa to a 37–3 victory. The win clinched another Big Ten title and another undefeated 7–0 record for the Hawkeyes. It is the only time in school history that the Hawkeyes have won consecutive conference titles.