Its main access is the Cagayan Valley National Highway that traverses in a general north–south direction virtually slicing the municipality lengthwise and connects it with other municipalities in Isabela. To the east lies a provincial road which links Quezon to the municipality of Santo Tomas, Isabela. Quezon is approximately south of the Cagayan Valley regional center of Tuguegarao City, about east of Tabuk City, the provincial capital of Kalinga province; and about north of Manila, the capital of the Philippines, with an average travel time of 8 to 9 hours by land.