He joined the University of Delhi soon after, where for the next forty years of his teaching career, he held important positions as the Head of the Department of Sanskrit, and the Dean of the Faculty of Arts. Satya Vrat Shastri was also the Vice-Chancellor of Shri Jagannath Sanskrit University, Puri, Orissa, and a visiting professor at the Chulalongkorn and Silpakorn Universities in Bangkok, as well as the Northeast Buddhist University, Nongkhai, Thailand, the University of Tübingen, Tübingen, Germany, the Catholic University, Leuven, Belgium, and the University of Alberta, Edmonton, Canada. He also taught Sanskrit to Thailand's Princess Maha Chakri Sirindhorn [1977–1979].