In May 2000, Kamall was a Conservative Candidate for the London Assembly. The following year, he was Conservative candidate for West Ham in the June 2001 General Election. He was placed fourth on the Conservative list in London for the 2004 European Parliament elections. The Conservatives won three seats and Kamall became a Member of the European Parliament in May 2005, after Theresa Villiers stepped down on being elected as an MP to the UK Parliament. In the European Parliament, he was a member of the Economic and Monetary Affairs, Legal Affairs and International Trade committees.