Some of the most pronounced effects of Hellenization can be seen in Afghanistan and India, in the region of the relatively late-rising Greco-Bactrian Kingdom (250–125 BC) (in modern Afghanistan, Pakistan, and Tajikistan) and the Indo-Greek Kingdom (180 BC – 10 AD) in modern Afghanistan and India. On the Silk Road trade routes, Hellenistic culture hybridized with Iranian and Buddhist cultures. The cosmopolitan art and mythology of Gandhara (a region spanning the upper confluence of the Indus, Swat and Kabul rivers in modern Pakistan) of the ~3rd century BC to the ~5th century AD are most evident of the direct contact between Hellenistic civilization and South Asia, as are the Edicts of Ashoka, which directly mention the Greeks within Ashoka's dominion as converting to Buddhism and the reception of Buddhist emissaries by Ashoka's contemporaries in the Hellenistic world. The resulting syncretism known as Greco-Buddhism influenced the development of Buddhism and created a culture of Greco-Buddhist art. These Greco-Buddhist kingdoms sent some of the first Buddhist missionaries to China, Sri Lanka and Hellenistic Asia and Europe (Greco-Buddhist monasticism).