NY 251 continues across open fields to the densely populated hamlet of Mendon, where it has a junction with NY 64 in the center of the community. East of the junction, NY 251 becomes Victor–Mendon Road as it heads out of Mendon. About from NY 64, the open surroundings return as the route crosses into the Ontario County town of Victor. NY 251 continues on a virtual east–west line for its first in the county, heading through slightly more developed but still sparsely populated areas. At Phillips Road, the route curves southeastward for before making one final turn to the northeast. On this last stretch, NY 251 crosses the Ontario Central Railroad at a grade crossing and ends at a junction with NY 96 northwest of the village of Victor.