Hitting his first triple in more than four years and 2,000 at bats, with the bases loaded, Molina provided the decisive run in a 3–2 outcome against the Chicago White Sox on July 22. In the annual "Baseball America" Toolbox Awards, managers and coaches around the National League rated Molina as both the "Best hit and run artist" and "Best defensive catcher" in the NL. His 100th career home run was well-timed, becoming the game-winning run in the bottom of the eighth inning at Busch Stadium on August 19 in a 4–3 win over San Francisco. After sustaining an injury to his left thumb during a September 20 game against the Cubs, an MRI revealed a partial ligament tear, preventing him from playing. Molina won his eighth consecutive Gold Glove Award and fourth Platinum Glove Award in 2015. In December, it was revealed that Molina had a second surgery on his left thumb, pushing his return to late in 2016 spring training. He was winner of the Darryl Kile Good Guy Award.