M-50 continues its journey through Jackson County, winding its way to the southeast through rural fields and small forests. The landscape transitions to residential neighborhoods as the road approaches the US 127 freeway north of Jackson. In Blackman Township, M-50 merges with US 127 to run concurrently into the north side of Jackson. After an interchange with I-94 at exit 138, US 127 exits to run east on I-94 for , M-50 and Business US 127 (Bus. US 127) run concurrently into the city as West Avenue passing by the Jackson Crossing shopping mall. The road then proceeds south through the northern side of the city before turning east on Michigan Avenue as it heads towards downtown.