Guy led the party to a disappointing showing at the November 2018 state election. The Liberal/National Coalition suffered large swings against it and lost several seats in Eastern Melbourne to the Labor Party. Guy's campaign focused chiefly on curbing crime in parts of Melbourne as well as seeking to shift population growth in Melbourne to regional Victoria, though this strategy failed to increase the Liberal vote in the state. Ultimately, the Coalition suffered an 11-seat swing, falling to only 27 seats. Guy resigned as leader of the Liberal Party on 28 November 2018.