A son of Giovanni II, Annibale II (1469-1540), married Lucrezia d'Este, an illegitimate daughter of Duke Ercole I of Ferrara, in 1487. He served as a condottiero. During a rebellion in 1511 against Julius II, Annibale II with the help of the French took control o Bologna, but he was able to rule for only a year. He was hated by other rival families, such as the Ghislieri and the Canetoli, and was subsequently assassinated. Annibale II was the last ruler of his line. In exile, the Bentivoglio family established themselves in Ferrara and produced several notable prelates.