Gambale has become identified with sweep picking and economy picking. His interest grew out of a desire to transcend the physical limits of the guitar and borrow from other instruments, such as the piano and saxophone. One advantage of the technique is that it allows him to play faster. He can also approximate the way chords are played on piano by using his invented tuning, the Gambale Tuning, in which "the whole guitar is tuned up a fourth, but the top two strings are down an octave" (A, D, G, C, E, A, low to high).