In 2005, Molina struggled with injuries and saw a drop off in the offensive performance in his rookie season. He doubled and scored on David Eckstein's go-ahead single on his way to three hits in a June 12 defeat of the New York Yankees, 5–3. Molina returned from a 33-game absence on August 19 induced by a hairline fracture of his left fifth metacarpal bone from being hit by a pitch on July 7. Starting pitcher Chris Carpenter, attempting to extend a winning streak to ten games on an August 19 game versus the San Francisco Giants, found himself in a 4–0 deficit in the ninth inning. Capped by Molina's three-run home run, the Cardinals rallied and won 5–4 in the ninth. The next day, Molina's suicide squeeze bunt scored Mark Grudzielanek, tying the game and allowing the Cardinals to win 4–2. Those were just two wins of 100 as St. Louis made their way to another division title following 105 wins the season before.