Guzzanti's career began when she took part in a series of successful television comedy formats such as "Proffimamente... non-stop" (directed by Enzo Trapani), "L'araba fenice" (directed by Antonio Ricci), "La TV delle ragazze" and "Scusate l'interruzione"; her imitations of the famous Italian porn star Moana Pozzi gave her popularity, and the Italian film director Giuseppe Bertolucci recruited her to star in his film "The Camels" ("I Cammelli"). Her career in this period was at its apex, as she starred in several films, toured Italian theatres with her own comedy shows (such as "Con fervido zelo" in 1991, and "Non io: Sabina e le altre" in 1994), and even held her one-woman show "La posta del cuore". Her first attempt at directing is the 1998 short "Donna selvaggia".