At the roundabout, MD 2 makes a turn to the northeast, passing through agricultural areas with some homes. The road intersects MD 255 (Owensville Road) before it curves northwest and passes through the community of Harwood, where it turns northeast and heads east of Southern High School. The route continues through rural land and passes through the community of Birdsville. The road heads northeast, with residential development increasing as the road approaches its intersection with MD 214 (Central Avenue). Here, MD 2 widens into a four-lane divided highway and heads through commercial areas, intersecting MD 253 (Mayo Road) adjacent to Lee Airport. Past this intersection, the road traverses residential areas before it crosses over the South River. The former alignments of MD 2 around the bridge are designated as MD 553. Upon crossing the river, MD 2 continues past residential neighborhoods and widens to six lanes. It comes to an interchange with MD 665 (Aris T. Allen Boulevard). Past the MD 665 interchange, the route heads into commercial areas on the outskirts of Annapolis, with MD 393 (Old Solomons Island Road) branching off from the route and paralleling it to the east. MD 2 crosses MD 450 (West Street) before the route merges onto US 50/US 301 and unsigned I-595 (John Hanson Highway).