In October 2009, Greenpeace East Asia released a report, "Poisoning the Pearl River" that detailed the results of a study it conducted in which 25 samples were collected from five manufacturing facilities in the Greater Pearl River Delta. The study concluded that all the facilities sampled were discharging waste-water containing chemicals with proven or suspected hazardous properties including beryllium, copper, manganese, and heavy metals, as well as high levels of organic chemicals. These substances are associated with a long list of health problems such as cancer, endocrine disruption, renal failure and damage to the nervous system as well being known to harm the environment. Three of the five facilities sampled (Qingyuan Top Dragon Co. Ltd, Wing Fung P.C. Board Co. Ltd. and Techwise Qingyuan Circuit Co. Ltd. ) contained concentrations of chemicals which exceeded the limits set by Guangdong provincial effluent standards. These companies were then subjected to a Clean Production Audit according to Article 28 of China's Cleaner Production Promotion Law. Guangdong Environmental Protection Bureau took a stance against the companies by blacklisting them.