The highway continues westward through the farmland as a two-lane road to the Monroe–Lenawee county line. US 223 meets its former routing and turns northwesterly along Lansing Road, crossing a branch of the Indiana & Ohio Railway. US 223 runs parallel to the Adrian & Blissfield Railroad that branches off southwest of the highway. Both the highway and rail line run northwesterly into Blissfield. The two cross while US 223 runs along Adrian Street through downtown, and the highway makes its first crossing of the River Raisin before leaving downtown. The second crossing is in Palmyra northwest of Blissfield.