Palmer returned healthy in 1969, rejoining an Orioles rotation that included 20-game winners Dave McNally and Mike Cuellar. He missed July with a six-week stint on the disabled list, but it was for a torn back muscle, not because of arm trouble. That August 13, Palmer threw a no-hitter against Oakland, just four days after coming off the disabled list. He finished the season with a mark of 16–4, 123 strikeouts, a 2.34 ERA, and .800 winning percentage. The heavily favored Orioles were beaten in the 1969 World Series by the New York Mets with Palmer taking the loss in Game 3.