Wielders of the Darkness exhibit a potent healing factor when injured - the shadows surrounding them absorbed into their body to regenerate cells at unnatural rates, even to the extent of regrowing lost limbs and reconstructing whole portions of the body that have been destroyed. This renders the vessels effectively impervious to disease and poisons as well as resistance to supernatural afflictions such as the powers of the Horsemen of the Apocalypse. This also allows them a degree of pseudo-immortality as the Darkness keeps them preserved over millennia.