At the MD 577 intersection, MD 313 runs northwest along the border of Caroline and Dorchester counties as Reliance Road. The route heads toward the town of Federalsburg, passing through a mix of agricultural and residential areas. The route then leaves the border line and enters Caroline County, intersecting MD 318 (Federalsburg Highway) and making a left turn to form a concurrency with that route. The two routes bypass Federalsburg to the south, crossing over Marshyhope Creek. After crossing the creek, the road intersects MD 308 (South Main Street). The road passes an industrial park before turning north into wooded areas and crossing the Maryland and Delaware Railroad's Seaford Line at-grade. After the railroad crossing, MD 313 and MD 318 intersect MD 307 (Williamsburg Road) at a roundabout located in the southwestern corner of Federalsburg. A short distance later, MD 318 splits from MD 313 by heading west on Preston Road while MD 315 continues east into Federalsburg on Bloomingdale Avenue. Past this intersection, MD 313 continues north on the Federalsburg Highway, leaving the Federalsburg area and heading into a mix of woodland and farmland.