Route 154 soon turns north, passing just to the west of North Cove. It then becomes concurrent with US 1 prior to intersecting Interstate 95 as the Middlesex Turnpike. Proceeding north, it intersects Route 9 before passing near South Cove, a separate cove than the one previously crossed over, although they are both an extension of the Connecticut River. It then intersects Route 9 again, before turning slightly east of north, and intersecting it for a third time. It then becomes known as Main Street while traveling parallel to the Connecticut River. It then intersects Route 148.