In downtown Jackson, Michigan Avenue continues into downtown while M-50 is routed around the city center along paired one-way streets. Washington Street carries eastbound traffic and the Louis Glick Highway. On the east side of downtown, the roads merge near the Jackson Amtrak station and a junction with M-106 on Cooper Street, where M-50 turns south and then southeast as Brooklyn Road. On the south side of Jackson, M-50 and US 127 meet up once again just east of Vandercook Lake. M-50 follows the US 127 freeway through a pair of conjoined partial interchanges before M-50 heads east away from Vandercook Lake.