Niles' start in the comics industry began with the formation of his self publishing company, Arcane Comix. Niles published, edited, and adapted several comics and anthologies for Eclipse Comics, working on "I Am Legend" in 1991. He then wrote several titles for Fantaco in the early 1990s, including "Bad Moon", "Fly in My Eye", and a set of lithographs for "Clive Barker's Book of Blood". He worked for a year on Disney's "Toy Story Web Adventures", and later worked for Todd McFarlane Productions where he wrote several issues of "Spawn", "Spawn: The Dark Ages". He also collaborated on "Hellspawn" with illustrator Ashley Wood after Brian Michael Bendis's departure, and did journalism work for "Kiss Magazine", interviewing members of the band Kiss.