In 2010, Balakrishna acted in Boyapati Srinu's film "Simha", alongside Nayantara and Sneha Ullal. He played a dual role as father and son. The film opened to positive reviews, and went on to become the highest-grossing Telugu film of the year. A review in Rediff said about his performance: "Balakrishna has put in a restrained performance. Though his character is supposed to roar at times, he seems subdued most of the time. But he's given plenty to be pleased about as it is his show all the way." In 2011, he acted in the mythological film "Sri Rama Rajyam", based on the epic Ramayana. He played a triple role in the 2012 action drama "Adhinayakudu" as grandfather, father and grandson. Balakrishna was the chief guest for the 43rd International Film Festival of India, 2012. In 2014, he acted in Boyapati Srinu's film "Legend", alongside Sonal Chauhan and Jagapathi Babu. He played the title role in the biographical and historical film "Gautamiputra Satakarni", his 100th film. The film is directed by Krish and is based on the life of the 2nd century ruler of the Satavahana dynasty, Gautamiputra Satakarni. In 2018, he acted in "Jai Simha", which was directed by K. S. Ravikumar and started shooting for the "N.T.R." biopic in which he reprised the role of his father, NTR. The film was made in two parts, the first part ' was released on 9 January 2019, with the second ' on 22 February 2019.