Nicolle’s success in expanding the Pasteur Institute in Tunis lies primarily in his deviation from the traditional pastorian ideology that mandated that medical aid and research be done in a nonprofit manner. Nicolle instead actively sought to build relations with the local Tunisian and French healthcare officials, and organized the Institute such that other medical functions (such as caring for sick patients) would monetarily support the Institute's ongoing laboratory research. Doing so gave him autonomy to run the Institute without relying on public or governmental funds. As the Institute grew more financially stable, Nicolle tackled the diseases and public health concerns that were prevalent in the local region, shared research findings and resources with the Paris Institute, and expanded his scientific writings into a journal called the "Archives de l’Institut de Tunis". He also became a key point of contact for the French government when new epidemics arose that required his intervention– such as in the malaria epidemic of 1906 and the cholera outbreak of 1907.