The regiment raised a 2nd Battalion in 1793 and became the 1st Grenadier Regiment of Bombay Native Infantry. The 2nd Battalion would, in 1824, be separated from the 1st Grenadiers to become the 2nd Grenadier Regiment of Bombay Native Infantry (later the 102nd King Edward's Own Grenadiers). The regiment helped to besiege the fort of Bharatpur from December 1825 to its capture on 18 January 1826. In 1843, the 1st Grenadiers served in the Scinde War, being engaged at Hyderabad in March. The war's conclusion brought about the annexation of Scinde. The regiment was extensively employed during the First Anglo-Sikh War and was present at the decisive Battle of Sobraon in February 1846.