commiss direct ec august adapt technic progress time council direct eec approxim law regul administr provis relat classif packag label danger substanc text eea relev commiss european commun regard treati establish european commun regard council direct eec june approxim law regul administr provis relat classif packag label danger substanc amend commiss direct ec articl thereof annex direct eec list danger substanc particular classif label substanc present scientif technic knowledg shown list danger substanc annex adapt technic progress specif tabl foreword annex requir inclus finnish swedish nomenclatur languag version direct requir technic correct specif section foreword annex publish updat recast version foreword annex list updat includ notifi substanc exist substanc ident nomenclatur classif label concentr limit substanc amend reflect increas technic knowledg entri substanc delet list cover entri annex ii direct eec list symbol indic danger danger substanc prepar annex iii direct eec list phrase indic natur special risk attribut danger substanc prepar annex iv direct eec list phrase indic safeti advic danger substanc prepar annex ii iii iv requir inclus finnish swedish word languag version direct requir technic correct specif section annex ii iii iv publish updat recast version annex ii iii iv articl european parliament council direct ec permit sweden januari decemb requir addit phrase list annex iii substanc classifi carcinogen categori phrase member state expert agre revis text phrase refer carcinogen categori substanc phrase ad annex iii origin text phrase classif label mutagen categori harm substanc list annex classif label concentr limit refer annex includ revis mutagen categori harm substanc annex direct eec lai method determin physicochem properti toxic ecotox substanc prepar adapt annex technic progress reduc minimum number anim experiment purpos accord council direct eec chapter delet altern method fewer anim due regard method recognis recommend compet intern organis method subchron oral toxic chapter revis chapter environment toxic ad annex languag version requir technic correct specif section annex annex vi direct eec guid classif label danger substanc prepar adapt annex technic progress languag version direct requir technic correct specif section annex vi specif section requir public finnish swedish publish updat recast version annex vi includ refer direct ec european parliament council approxim law regul administr provis member state relat classif packag label danger prepar accord provis direct eec substanc market notifi compet author member state mean notif inform includ technic dossier substanc suppli consum chemic reaction strictli control intermedi limit exposur technic justifi defin reduc test packag rtp current technic progress guarante minimum exposur man environ rigor contain process technic dossier test packag intermedi limit exposur suppli inform evalu forese risk man environ annex vii content technic dossier annex viii detail addit test studi requir intermedi limit exposur market higher volum criteria notif intermedi limit exposur revis light technic progress experi gain notif made accord specif requir laid direct measur provid direct accord opinion committe adapt technic progress direct elimin technic barrier trade danger substanc prepar adopt direct articl direct eec amend annex amend tabl foreword annex includ finnish swedish nomenclatur languag version direct includ technic correct specif section foreword tabl foreword includ tabl replac annex direct entri replac entri annex direct entri annex direct insert entri annex direct delet entri shown annex direct amend replac classif refer quot muta cat quot quot muta cat quot replac label refer entri shown annex direct amend replac classif refer quot xn quot quot xn quot replac label refer entri shown annex direct amend replac concentr limit refer quot xn quot quot xn quot entri shown annex direct amend replac concentr limit refer quot xn quot quot xn quot entri shown annex direct amend replac classif refer quot muta cat quot quot muta cat quot entri shown annex direct amend replac classif refer quot muta cat quot quot muta cat quot ad label annex ii includ swedish finnish version technic correct languag version annex ii replac annex direct annex iii includ swedish finnish version technic correct languag version annex iii replac annex direct annex iv includ swedish finnish version technic correct languag version annex iv replac annex direct annex amend chapter delet titl english version chapter replac text annex sentenc french version paragraph chapter replac text annex equat sentenc section english version chapter replac text annex test method subchron oral toxic test rodent amend accord annex direct replac chapter test method subchron oral toxic test rodent amend accord annex direct replac chapter test method environment toxic annex direct includ part annex vi includ swedish finnish version technic correct languag version detail technic updat annex vi replac annex direct annex vii includ technic dossier test packag intermedi limit exposur suppli inform evalu forese risk man environ annex vii amend text annex direct insert section annex vii text annex direct insert end annex vii annex viii includ addit test studi requir intermedi limit exposur market higher volum annex viii amend text annex direct insert quot level quot quot physicochem studi quot annex viii text annex direct insert quot level quot quot toxicolog studi quot annex viii articl member state adopt publish juli law regul administr provis compli direct forthwith inform commiss thereof member state appli law regul administr provis refer paragraph juli earlier date danger substanc juli prepar scope council direct eec european parliament council direct ec juli prepar scope direct eec direct ec forthwith inform commiss thereof member state adopt provis refer direct accompani refer occas offici public member state determin refer made member state commun commiss main provis nation law adopt field cover direct correl tabl direct nation provis adopt articl direct enter forc dai public offici journal european commun articl direct address member state brussel august commiss margot wallström member commiss oj oj oj oj oj oj oj annex foreword annex introduct annex index danger substanc harmonis classif label agre commun level accord procedur laid articl direct number entri entri annex list atom number element characterist substanc properti list chemic element arrang atom number shown tabl organ substanc varieti usual class shown tabl index number substanc form digit sequenc type abc rst vw abc atom number characterist chemic element preced zero make sequenc usual class number organ substanc rst consecut number substanc seri abc vw denot form substanc produc market check digit calcul accord isbn intern standard book number method index number sodium chlorat danger substanc european inventori exist commerci chemic substanc einec oj einec number includ number digit system type xxx xxx start danger substanc notifi provis direct number substanc european list notifi substanc elinc includ number digit system type xxx xxx start danger substanc list quot longer polym quot document offic offici public european commun isbn quot longer polym quot number includ number digit system type xxx xxx start chemic abstract servic ca number includ assist identif entri note einec number includ anhydr hydrat form substanc frequent ca number anhydr hydrat form ca number includ anhydr form ca number shown describ entri accur einec number einec elinc quot longer polym quot ca number includ entri compris individu substanc nomenclatur danger substanc design einec elinc quot longer polym quot name substanc list einec elinc list quot longer polym quot design internation recognis chemic iso iupac addit common includ case impur addit minor compon mention contribut significantli classif substanc substanc mixtur entri refer specif mixtur case characteris substanc put market proport main substanc mixtur substanc specif percentag puriti substanc higher content activ materi organ peroxid includ annex entri hazard properti explos specif concentr limit shown appli substanc substanc shown entri case entri mixtur substanc substanc specif percentag puriti limit appli substanc annex pure substanc articl requir substanc appear annex substanc label design annex substanc addit inform ad squar bracket order identifi substanc addit inform includ label entri refer impur index methyl acrylamidomethoxyacet amp gt acrylamid case refer bracket form part includ label entri refer group substanc index quot hydrogen cyanid salt except complex cyanid ferrocyanid ferricyanid mercur oxycyanid quot individu substanc cover entri einec internation recognis format entri inform substanc annex classif process classif consist place substanc categori danger defin articl council direct eec oj assign qualifi risk phrase phrase classif consequ label legisl regulatori measur danger substanc ii classif categori danger present form abbrevi repres categori danger risk phrase phrase case substanc classifi flammabl sensitis substanc classifi danger environ risk phrase iii abbrevi categori danger shown explos oxidis extrem flammabl highli flammabl flammabl toxic toxic harm xn corros irrit xi sensitis carcinogen carc cat mutagen muta cat toxic reproduct repr cat danger environ iv addit risk phrase assign describ properti section label guid shown formal part classif label includ letter assign substanc accord annex ii articl act abbrevi symbol indic danger assign ii risk phrase denot seri number preced letter indic natur special risk accord annex iii articl number separ dash denot separ statement special risk obliqu stroke denot combin statement singl sentenc special risk set annex iii iii safeti phrase denot seri number preced letter indic recommend safeti precaut accord annex iv articl number separ dash obliqu stroke signific recommend safeti precaut set annex iv safeti phrase shown appli substanc prepar phrase select usual rule note danger substanc prepar sold gener public phrase mandatori obligatori toxic toxic corros substanc prepar sold gener public obligatori danger substanc prepar sold gener public classifi danger environ safeti phrase shown bracket annex omit label substanc prepar sold industri concentr limit classif classifi danger prepar substanc accord direct ec shown concentr limit percentag weight substanc calcul refer total weight prepar concentr limit concentr limit appli convent method assess health hazard annex ii appli convent method assess environment hazard annex iii european parliament council direct ec oj gener explanatori note group substanc number group entri includ annex case classif label requir appli substanc cover descript market list einec elinc substanc cover group entri occur impur substanc classif label requir group entri account label substanc case classif label requir specif substanc cover group entri case specif annex entri present substanc group entri annot phrase quot annex quot case individu substanc cover group entri lead oxal einec instanc cover entri lead compound index salt oxal acid case label substanc reflect label group entri case classif hazard classif lead sever classif label substanc section note entri annex salt denomin cover anhydr hydrou form specif substanc elinc number annex substanc elinc number notifi provis direct produc import previous notifi substanc refer provis direct intend place substanc market explan note relat identif classif label substanc note substanc label form design annex articl annex made gener descript quot compound quot quot salt quot case manufactur person market substanc requir state label correct due account chapter entitl quot nomenclatur quot foreword becl einec beryllium chlorid direct requir symbol indic danger phrase substanc shown annex articl substanc belong group substanc includ annex symbol indic danger phrase substanc shown entri annex substanc belong group substanc includ annex symbol indic danger phrase substanc shown entri annex case classif entri hazard classif reflect sever hazard classif substanc ab individu entri annex annex group entri compound repr cat repr cat xn annex group entri compound carc cat classif substanc ab carc cat repr cat repr cat note substanc acid base market aqueou solut concentr solut requir label hazard vari concentr annex entri note gener design type quot nitric acid quot case manufactur person market substanc aqueou solut state percentag concentr solut label nitric acid state assum percentag concentr calcul weight weight basi addit data specif graviti degre baumé descript phrase fume glacial permiss note organ substanc market specif isomer form mixtur isom annex gener design type quot xylenol quot case manufactur person market substanc state label substanc specif isom mixtur isom dimethylphenol xylenol mixtur isom note substanc suscept spontan polymeris decomposit gener market stabilis form form list annex direct substanc market stabilis form case manufactur person place substanc market state label substanc word quot stabilis quot methacryl acid stabilis note substanc specif effect human health chapter annex vi classifi carcinogen mutagen toxic reproduct categori ascrib note classifi toxic toxic harm xn substanc risk phrase harm combin risk phrase preced word quot quot exampl quot cancer toxic inhal quot quot herit genet damag toxic contact skin swallow quot note substanc stabilis stabilis danger properti substanc label annex label provid accord rule label danger prepar note substanc market explos form case evalu test method label provid reflect explos properti note classif label shown substanc appli danger properti i risk phrase combin categori i danger shown requir articl direct manufactur distributor import substanc appli aspect classif label final label follow requir section annex vi direct note appli coal oil deriv substanc entri group substanc annex note classif carcinogen appli shown substanc benzen einec note appli complex coal oil deriv substanc annex note classif carcinogen appli shown substanc butadien einec substanc classifi carcinogen phrase appli note appli complex oil deriv substanc annex note classif carcinogen appli shown substanc dmso extract measur ip note appli complex oil deriv substanc annex note classif carcinogen appli shown substanc benzo pyren einec note appli complex coal deriv substanc annex note classif carcinogen appli full refin histori shown substanc produc carcinogen note appli complex oil deriv substanc annex note classif carcinogen appli shown substanc benzen einec substanc classifi carcinogen note appli substanc classifi carcinogen phrase appli note appli complex oil deriv substanc annex note classif carcinogen appli shown substanc fulfil condit short term biopersist test inhal shown fibr longer µm weight half life dai short term biopersist test intratrach instil shown fibr longer µm weight half life dai intra periton test shown evid excess carcinogen absenc relev pathogen neoplast suitabl long term inhal test note classif carcinogen appli fibr length weight geometr diamet standard geometr error greater µm note substanc requir label articl section annex vi explan note relat label prepar signific note concentr limit note concentr state absenc concentr gener concentr direct ec percentag weight metal element calcul refer total weight prepar note concentr isocyan state percentag weight free monom calcul refer total weight prepar note concentr state percentag weight chromat ion dissolv water calcul refer total weight prepar note prepar substanc classifi harm meet criteria section annex vi note concentr limit gaseou prepar express volum volum percentag note prepar substanc assign meet criteria section annex vi note longer appli date criteria provid direct ec enter forc tabla tabel tabel tabl tableau tabella tabel tabela tabel taulukko lista de lo elemento químico clasificado por su número atómico list grundstoff ordnet efter dere atomvægt list der chemischen element geordnet nach der ordnungszahl list chemic element list atom number list de élément chimiqu classé selon leur numéro atomiqu elenco degli elementi chimici ordinati secondo il loro numero atomico lijst van chemisch elementen gerangschikt naar atoomgewicht lista do elemento químico ordenado segundo seu número atómico lista över grundämnen ordnad efter dera atomnumm alkuaineiden luettelo järjestysluvun mukaan gt tabl gt tabla tabel tabel tabl tableau tabella tabel tabela tabel taulukko clasificación especi para la sustancia orgánica særlig inddel af organisk stoffer speziel anordnung für die organischen stoff special classif organ substanc classif particulièr aux substanc organiqu classificazion special le sostanz organich special indel voor de organisch stoffen classificação especi para substância orgânica särskild indeln av organiska ämnen erityisryhmät orgaanisil aineil gt tabl gt categori carcinogen mutagen toxic reproduct shown categori carcinogen mutagen toxic reproduct shown categori carcinogen mutagen toxic reproduct shown annex gt tabl gt annex gt tabl gt annex index annex index annex index annex index annex index annex index annex index annex anexo ii bilag ii anhang ii annex ii annex ii allegato ii bijlag ii anexo ii liit ii bilaga ii anexo ii símbolo indicacion de peligro de la sustancia preparado peligroso bilag ii faresymbol og farebetegnels farlig stoffer og præparat anhang ii gefahrensymbol und bezeichnungen für gefährlich stoff und zubereitungen annex ii symbol indic danger danger substanc prepar annex ii symbol indic de danger de substanc préparat dangereus allegato ii simboli indicazioni di pericolo dell sostanz preparati pericolosi bijlag ii gevaarsymbolen en aanduidingen van gevaarlijk stoffen en preparaten anexo ii símbolo indicaçõ de perigo da substância preparaçõ perigosa liit ii varoitusmerkit ja niiden nimet vaarallisil aineil ja valmisteil bilaga ii farosymbol och farobeteckningar för farliga ämnen och beredningar nota la letra xn xi forman part del símbolo bemærkn bogstavern xn xi og udgør ikk en del af symbolet anmerkung die buchstaben xn xi und sind nicht bestandteil de gefahrensymbol xn xi note letter xn xi form part symbol remarqu le lettr xn xi ne font pa parti du symbol nota le letter xn xi fanno part del simbolo opmerk de letter xn xi en maken geen deel uit van het gevaarsymbool nota letra xn xi não fazem part símbolo huomautu varoitusmerkkien kirjaintunnukset xn xi ja eivät ol osa varoitusmerkkiä anmärkn bokstäverna xn xi och utgör int en del av symbolen gt pic file quot en tif quot gt es explosivo da eksplosiv de explosionsgefährlich el en explos fr explosif esplosivo nl ontplofbaar pt explosivo fi räjähtävä sv explosivt gt pic file quot en tif quot gt es comburent da brandnærend de brandfördernd el en oxidis fr combur comburent nl oxiderend pt comburent fi hapettava sv oxiderand gt pic file quot en tif quot gt es fácilment inflam da meget brandfarlig de leichtentzündlich el en highli flammabl fr facil inflamm facilment infiammabil nl licht ontvlambaar pt facilment inflamável fi helposti syttyvä sv mycket brandfarligt gt pic file quot en tif quot gt es extremadament inflam da yderst brandfarlig de hochentzündlich el en extrem flammabl fr extrêmement inflamm estremament infiammabil nl zeer licht ontvlambaar pt extremament inflamável fi erittäin helposti syttyvä sv extremt brandfarligt gt pic file quot en tif quot gt es tóxico da giftig de giftig el en toxic fr toxiqu tossico nl vergiftig pt tóxico fi myrkyllinen sv giftig gt pic file quot en tif quot gt es mui tóxico da meget giftig de sehr giftig el en toxic fr trè toxiqu molto tossico nl zeer vergiftig pt muito tóxico fi erittäin myrkyllinen sv mycket giftig gt pic file quot en tif quot gt es corrosivo da ætsend de ätzend el en corros fr corrosif corrosivo nl bijtend pt corrosivo fi syövyttävä sv frätand xn gt pic file quot en tif quot gt es nocivo da sundhedsskadelig de gesundheitsschädlich el en harm fr nocif nocivo nl schadelijk pt nocivo fi haitallinen sv hälsoskadlig xi gt pic file quot en tif quot gt es irritant da lokalirriterend de reizend el en irrit fr irrit irritant nl irriterend pt irritant fi ärsyttävä sv irriterand gt pic file quot en tif quot gt es peligroso para el medio ambient da miljøfarlig de umweltgefährlich el en danger environ fr dangereux pour environn pericoloso ambient nl milieugevaarlijk pt perigoso para ambient fi ympäristöll vaarallinen sv miljöfarlig annex anexo iii bilag iii anhang iii annex iii annex iii allegato iii bijlag iii anexo iii liit iii bilaga iii anexo iii naturaleza de lo riesgo específico atribuido la sustancia preparado peligroso bilag iii arten af de særlige risici der er forbundet med de farlig stoffer og præparat anhang iii bezeichnungen der besonderen gefahren bei gefährlichen stoffen und zubereitungen annex iii natur special risk attribut danger substanc prepar annex iii natur de risqu particuli attribué aux substanc préparat dangereus allegato iii natura dei rischi specifici attribu all sostanz preparati pericolosi bijlag iii aard der bijzonder gevaren toegeschreven aan gevaarlijk stoffen en preparaten anexo iii natureza do risco específico atribuído às substância preparaçõ perigosa liit iii erityisten vaarojen luonn liittyen vaarallisiin aineisiin ja valmisteisiin bilaga iii riskfras som tilldela farliga ämnen och beredningar es explosivo en estado seco da eksplosiv tør tilstand de trockenem zustand explosionsgefährlich el en explos dry fr explosif état sec esplosivo allo stato secco nl droge toestand ontplofbaar pt explosivo estado seco fi räjähtävää kuivana sv explosivt torrt tillstånd es riesgo de explosión por choqu fricción fuego otra fuent de ignición da eksplosionsfarlig ved stød gnidn ild eller andr antændelseskild de durch schlag reibung feuer oder ander zündquellen explosionsgefährlich el en risk explos shock friction fire sourc ignit fr risqu explos par le choc la friction le feu ou autr sourc ignit rischio di esplosion urto sfregamento fuoco altr sorgenti ignizion nl ontploffingsgevaar door schok wrijv vuur ander ontstekingsoorzaken pt risco de explosão por choqu fricção fogo ou outra font de ignição fi räjähtävää iskun hankauksen avotulen tai muun sytytyslähteen vaikutuksesta sv explosivt vid stöt friktion eld eller annan antändningsorsak es alto riesgo de explosión por choqu fricción fuego otra fuent de ignición da meget eksplosionsfarlig ved stød gnidn ild eller andr antændelseskild de durch schlag reibung feuer oder ander zündquellen besond explosionsgefährlich el en extrem risk explos shock friction fire sourc ignit fr grand risqu explos par le choc la friction le feu ou autr sourc ignit elevato rischio di esplosion urto sfregamento fuoco altr sorgenti ignizion nl ernstig ontploffingsgevaar door schok wrijv vuur ander ontstekingsoorzaken pt grand risco de explosão por choqu fricção fogo ou outra font de ignição fi erittäin helposti räjähtävää iskun hankauksen avotulen tai muun sytytyslähteen vaikutuksesta sv mycket explosivt vid stöt friktion eld eller annan antändningsorsak es forma compuesto metálico explosivo mui sensibl da danner meget følsomm eksplos metalforbindels de bildet hochempfindlich explosionsgefährlich metallverbindungen el en form sensit explos metal compound fr form de composé métalliqu explosif trè sensibl forma composti metallici esplosivi molto sensibili nl vormt met metalen zeer gemakkelijk ontplofbar verbindingen pt forma composto metálico explosivo muito sensívei fi muodostaa erittäin herkästi räjähtäviä metalliyhdisteitä sv bildar mycket känsliga explosiva metallföreningar es peligro de explosión en caso de calentamiento da eksplosionsfarlig ved opvarmn de beim erwärmen explosionsfähig el en heat explos fr danger explos sou action de la chaleur pericolo di esplosion riscaldamento nl ontploffingsgevaar door verwarm pt perigo de explosão sob acção calor fi räjähdysvaarallinen kuumennettaessa sv explosivt vid uppvärmn es peligro de explosión en contacto sin contacto con el air da eksplosiv ved og uden kontakt med luft de mit und ohn luft explosionsfähig el en explos contact air fr danger explos en contact ou san contact avec air esplosivo contatto senza contatto con aria nl ontplofbaar met en zonder lucht pt perigo de explosão ou sem contacto ar fi räjähtävää sellaisenaan tai ilman kanssa sv explosivt vid kontakt och utan kontakt med luft es pued provocar incendio da kan forårsag brand de kann brand verursachen el en fire fr peut provoqu incendi può provocar incendio nl kan brand veroorzaken pt pode provocar incêndio fi aiheuttaa tulipalon vaaran sv kan orsaka brand es peligro de fuego en contacto con materia combust da brandfarlig ved kontakt med brandbar stoffer de feuergefahr bei berührung mit brennbaren stoffen el en contact combust materi fire fr favoris inflamm de matièr combust può provocar accension di materi combustibili nl bevordert de ontbrand van brandbar stoffen pt favorec inflamação de matéria combustívei fi aiheuttaa tulipalon vaaran palavien aineiden kanssa sv kontakt med brännbart materi kan orsaka brand es peligro de explosión al mezclar con materia combust da eksplosionsfarlig ved bland med brandbar stoffer de explosionsgefahr bei mischung mit brennbaren stoffen el en explos mix combust materi fr peut explos en mélang avec de matièr combust esplosivo miscela con materi combustibili nl ontploffingsgevaar bij meng met brandbar stoffen pt pode explodir quando misturado matéria combustívei fi räjähtävää sekoitettaessa palavien aineiden kanssa sv explosivt vid blandn med brännbart materi es inflam da brandfarlig de entzündlich el en flammabl fr inflamm infiammabil nl ontvlambaar pt inflamável fi syttyvää sv brandfarligt es fácilment inflam da meget brandfarlig de leichtentzündlich el en highli flammabl fr facil inflamm facilment infiammabil nl licht ontvlambaar pt facilment inflamável fi helposti syttyvää sv mycket brandfarligt es extremadament inflam da yderst brandfarlig de hochentzündlich el en extrem flammabl fr extrêmement inflamm estremament infiammabil nl zeer licht ontvlambaar pt extremament inflamável fi erittäin helposti syttyvää sv extremt brandfarligt es reacciona violentament con el agua da reager voldsomt med vand de reagiert heftig mit wasser el en react violent water fr réagit violem au contact de eau reagisc violentement con acqua nl reageert heftig met water pt reag violentament em contacto água fi reagoi voimakkaasti veden kanssa sv reagerar häftigt med vatten es reacciona con el agua liberando gase extremadament inflam da reager med vand dannels af yderst brandfarlig gasser de reagiert mit wasser unter bildung hochentzündlich gase el en contact water liber extrem flammabl gase fr au contact de eau dégage de gaz extrêmement inflamm contatto con acqua libera ga estremament infiammabili nl vormt zeer licht ontvlambaar ga contact met water pt em contacto água liberta gase extremament inflamávei fi vapauttaa erittäin helposti syttyviä kaasuja veden kanssa sv vid kontakt med vatten bilda extremt brandfarliga gaser es pued explosionar en mezcla con substancia comburent da eksplosionsfarlig ved bland med oxiderend stoffer de explosionsgefährlich mischung mit brandfördernden stoffen el en explos mix oxidis substanc fr peut explos en mélang avec de substanc comburant pericolo di esplosion se mescolato con sostanz comburenti nl ontploffingsgevaar bij meng met oxiderend stoffen pt explosivo quando misturado substância comburent fi räjähtävää hapettavien aineiden kanssa sv explosivt vid blandn med oxiderand ämnen es se inflama espontáneament en contacto con el air da selvantændelig luft de selbstentzündlich der luft el en spontan flammabl air fr spontané inflamm air spontaneament infiammabil aria nl spontaan ontvlambaar lucht pt espontaneament inflamável ao ar fi itsestään syttyvää ilmassa sv självantänder luft es al usarlo pueden formars mezcla air vapor explosiva inflam da ved brug kan brandbar damp eksplos damp luftblanding dann de bei gebrauch bildung explosionsfähig leichtentzündlich dampf luft gemisch möglich el en form flammabl explos vapour air mixtur fr lor de utilis format de mélang vapeur air inflamm explosif durant uso può formar con aria miscel esplos infiammabili nl kan bij gebruik een ontvlambaar ontplofbaar damp luchtmengsel vormen pt pode formar mistura vapor ar explosiva inflamável durant utilização fi käytössä voi muodostua syttyvä räjähtävä höyri ilmaseo sv vid användn kan brännbara explosiva ång luftblandningar bilda es pued formar peróxido explosivo da kan dann eksplos peroxid de kann explosionsfähig peroxid bilden el en form explos peroxid fr peut de peroxyd explosif può formar perossidi esplosivi nl kan ontplofbar peroxiden vormen pt pode formar peróxido explosivo fi saattaa muodostaa räjähtäviä peroksideja sv kan bilda explosiva peroxid es nocivo por inhalación da farlig ved indånd de gesundheitsschädlich beim einatmen el en harm inhal fr nocif par inhal nocivo inalazion nl schadelijk bij inadem pt nocivo por inalação fi terveydel haitallista hengitettynä sv farligt vid inandn es nocivo en contacto con la piel da farlig ved hudkontakt de gesundheitsschädlich bei berührung mit der haut el en harm contact skin fr nocif par contact avec la peau nocivo contatto con la pell nl schadelijk bij aanrak met de huid pt nocivo em contacto pele fi terveydel haitallista joutuessaan ihol sv farligt vid hudkontakt es nocivo por ingestión da farlig ved indtagels de gesundheitsschädlich beim verschlucken el en harm swallow fr nocif en ca ingest nocivo ingestion nl schadelijk bij opnam door de mond pt nocivo por ingestão fi terveydel haitallista nieltynä sv farligt vid förtäring es tóxico por inhalación da giftig ved indånd de giftig beim einatmen el en toxic inhal fr toxiqu par inhal tossico inalazion nl vergiftig bij inadem pt tóxico por inalação fi myrkyllistä hengitettynä sv giftigt vid inandn es tóxico en contacto con la piel da giftig ved hudkontakt de giftig bei berührung mit der haut el en toxic contact skin fr toxiqu par contact avec la peau tossico contatto con la pell nl vergiftig bij aanrak met de huid pt tóxico em contacto pele fi myrkyllistä joutuessaan ihol sv giftigt vid hudkontakt es tóxico por ingestión da giftig ved indtagels de giftig beim verschlucken el en toxic swallow fr toxiqu en ca ingest tossico ingestion nl vergiftig bij opnam door de mond pt tóxico por ingestão fi myrkyllistä nieltynä sv giftigt vid förtäring es mui tóxico por inhalación da meget giftig ved indånd de sehr giftig beim einatmen el en toxic inhal fr trè toxiqu par inhal molto tossico inalazion nl zeer vergiftig bij inadem pt muito tóxico por inalação fi erittäin myrkyllistä hengitettynä sv mycket giftigt vid inandn es mui tóxico en contacto con la piel da meget giftig ved hudkontakt de sehr giftig bei berührung mit der haut el en toxic contact skin fr trè toxiqu par contact avec la peau molto tossico contatto con la pell nl zeer vergiftig bij aanrak met de huid pt muito tóxico em contacto pele fi erittäin myrkyllistä joutuessaan ihol sv mycket giftigt vid hudkontakt es mui tóxico por ingestión da meget giftig ved indtagels de sehr giftig beim verschlucken el en toxic swallow fr trè toxiqu en ca ingest molto tossico ingestion nl zeer vergiftig bij opnam door de mond pt muito tóxico por ingestão fi erittäin myrkyllistä nieltynä sv mycket giftigt vid förtäring es en contacto con agua libera gase tóxico da udvikl giftig ga ved kontakt med vand de entwickelt bei berührung mit wasser giftig gase el en contact water liber toxic ga fr au contact de eau dégage de gaz toxiqu contatto con acqua libera ga tossici nl vormt vergiftig ga contact met water pt em contacto água liberta gase tóxico fi kehittää myrkyllistä kaasua veden kanssa sv utvecklar giftig ga vid kontakt med vatten es pued inflamars fácilment al usarlo da kan blive meget brandfarlig brug de kann bei gebrauch leicht entzündlich werden el en highli flammabl fr peut devenir facil inflamm pendant utilis può divenir facilment infiammabil durant uso nl kan bij gebruik licht ontvlambaar worden pt pode tornar se facilment inflamável durant uso fi käytettäessä voi muuttua helposti syttyväksi sv kan bli mycket brandfarligt vid användn es en contacto con ácido libera gase tóxico da udvikl giftig ga ved kontakt med syre de entwickelt bei berührung mit säure giftig gase el en contact acid liber toxic ga fr au contact acid dégage gaz toxiqu contatto con acidi libera ga tossico nl vormt vergiftig gassen contact met zuren pt em contacto ácido liberta gase tóxico fi kehittää myrkyllistä kaasua hapon kanssa sv utvecklar giftig ga vid kontakt med syra es en contacto con ácido libera gase mui tóxico da udvikl meget giftig ga ved kontakt med syre de entwickelt bei berührung mit säure sehr giftig gase el en contact acid liber toxic ga fr au contact acid dégage gaz trè toxiqu contatto con acidi libera ga molto tossico nl vormt zeer vergiftig gassen contact met zuren pt em contacto ácido liberta gase muito tóxico fi kehittää erittäin myrkyllistä kaasua hapon kanssa sv utvecklar mycket giftig ga vid kontakt med syra es peligro de efecto acumulativo da kan ophob kroppen efter gentagen brug de gefahr kumulativ wirkungen el en danger cumul effect fr danger effet cumulatif pericolo di effetti cumulativi nl gevaar voor cumulatiev effecten pt perigo de efeito cumulativo fi terveydellisten haittojen vaara pitkäaikaisessa altistuksessa sv kan ansamla kroppen och ge skador es provoca quemadura da ætsningsfar de verursacht verätzungen el en burn fr provoqu de brûlure provoca ustioni nl veroorzaakt brandwonden pt provoca queimadura fi syövyttävää sv frätand es provoca quemadura grave da alvorlig ætsningsfar de verursacht schwere verätzungen el en sever burn fr provoqu de grave brûlure provoca gravi ustioni nl veroorzaakt ernstig brandwonden pt provoca queimadura grave fi voimakkaasti syövyttävää sv starkt frätand es irrita lo ojo da irriter øjnene de reizt die augen el en irrit ey fr irrit pour le yeux irritant gli occhi nl irriterend voor de ogen pt irritant para os olho fi ärsyttää silmiä sv irriterar ögonen es irrita la vía respiratoria da irriter åndedrætsorganern de reizt die atmungsorgan el en irrit respiratori system fr irrit pour le voi respiratoir irritant le vie respiratori nl irriterend voor de ademhalingswegen pt irritant para via respiratória fi ärsyttää hengityselimiä sv irriterar andningsorganen es irrita la piel da irriter huden de reizt die haut el en irrit skin fr irrit pour la peau irritant la pell nl irriterend voor de huid pt irritant para pele fi ärsyttää ihoa sv irriterar huden es peligro de efecto irrevers mui grave da fare varig alvorlig skade på helbr de ernst gefahr irreversiblen schaden el en danger irrevers effect fr danger effet irrévers trè grave pericolo di effetti irreversibili molto gravi nl gevaar voor ernstig onherstelbar effecten pt perigo de efeito irreversívei muito grave fi erittäin vakavien pysyvien vaurioiden vaara sv risk för mycket allvarliga beståend hälsoskador es posibl efecto cancerígeno da muligh kræftfremkaldend effekt de verdacht auf krebserzeugend wirkung el en limit evid carcinogen effect fr effet cancérogèn suspecté preuv insuffisant possibilità di effetti cancerogeni prove insufficienti nl carcinogen effecten zijn niet uitgesloten pt possibilidad de efeito cancerígeno fi epäillään aiheuttavan syöpäsairauden vaaraa sv misstänk kunna ge cancer es riesgo de lesion ocular grave da risiko alvorlig øjenskad de gefahr ernster augenschäden el en risk damag ey fr risqu de lésion oculair grave rischio di gravi lesioni oculari nl gevaar voor ernstig oogletsel pt risco de lesõ ocular grave fi vakavan silmävaurion vaara sv risk för allvarliga ögonskador es posibilidad de sensibilización por inhalación da kan give overfølsomh ved indånd de sensibilisierung durch einatmen möglich el en sensitis inhal fr peut entraîn un sensibilis par inhal può provocar sensibilizzazion inalazion nl kan overgevoeligheid veroorzaken bij inadem pt pode causar sensibilização por inalação fi altistuminen hengitysteits voi aiheuttaa herkistymistä sv kan ge allergi vid inandn es posibilidad de sensibilización en contacto con la piel da kan give overfølsomh ved kontakt med huden de sensibilisierung durch hautkontakt möglich el en sensitis skin contact fr peut entraîn un sensibilis par contact avec la peau può provocar sensibilizzazion contatto con la pell nl kan overgevoeligheid veroorzaken bij contact met de huid pt pode causar sensibilização em contacto pele fi ihokosketu voi aiheuttaa herkistymistä sv kan ge allergi vid hudkontakt es riesgo de explosión al calentarlo en ambient confinado da eksplosionsfarlig ved opvarmn indeslutn de explosionsgefahr bei erhitzen unter einschluss el en risk explos heat confin fr risqu explos si chauffé en ambianc confiné rischio di esplosion riscaldamento ambient confinato nl ontploffingsgevaar bij verwarm afgesloten toestand pt risco de explosão se aquecido em ambient fechado fi räjähdysvaara kuumennettaessa suljetussa astiassa sv explosionsrisk vid uppvärmn sluten behållar es pued causar cáncer da kan fremkald kræft de kann kreb erzeugen el en cancer fr peut provoqu le cancer può provocar il cancro nl kan kanker veroorzaken pt pode causar cancro fi aiheuttaa syöpäsairauden vaaraa sv kan ge cancer es pued causar alteracion genética hereditaria da kan forårsag arvelig genetisk skader de kann vererbbar schäden verursachen el en herit genet damag fr peut provoqu de altérat génétiqu héréditair può provocar alterazioni genetich ereditari nl kan erfelijk genetisch schade veroorzaken pt pode causar alteraçõ genética hereditária fi saattaa aiheuttaa periytyviä perimävaurioita sv kan ge ärftliga genetiska skador es riesgo de efecto grave para la salud en caso de exposición prolongada da alvorlig sundhedsfar ved længere tid påvirkn de gefahr ernster gesundheitsschäden bei längerer exposit el en danger damag health prolong exposur fr risqu effet grave pour la santé en ca exposit prolongé pericolo di gravi danni la salut caso di esposizion prolungata nl gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel pt risco de efeito grave para saúd em caso de exposição prolongada fi pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel sv risk för allvarliga hälsoskador vid långvarig expon es pued causar cáncer por inhalación da kan fremkald kræft ved indånd de kann kreb erzeugen beim einatmen el en cancer inhal fr peut provoqu le cancer par inhal può provocar il cancro inalazion nl kan kanker veroorzaken bij inadem pt pode causar cancro por inalação fi aiheuttaa syöpäsairauden vaaraa hengitettynä sv kan ge cancer vid inandn es mui tóxico para lo organismo acuático da meget giftig organism der lever vand de sehr giftig für wasserorganismen el en toxic aquat organ fr trè toxiqu pour le organism aquatiqu altament tossico gli organismi acquatici nl zeer vergiftig voor het water levend organismen pt muito tóxico para os organismo aquático fi erittäin myrkyllistä vesieliöil sv mycket giftigt för vattenlevand organism es tóxico para lo organismo acuático da giftig organism der lever vand de giftig für wasserorganismen el en toxic aquat organ fr toxiqu pour le organism aquatiqu tossico gli organismi acquatici nl vergiftig voor het water levend organismen pt tóxico para os organismo aquático fi myrkyllistä vesieliöil sv giftigt för vattenlevand organism es nocivo para lo organismo acuático da skadelig organism der lever vand de schädlich für wasserorganismen el en harm aquat organ fr nocif pour le organism aquatiqu nocivo gli organismi acquatici nl schadelijk voor het water levend organismen pt nocivo para os organismo aquático fi haitallista vesieliöil sv skadligt för vattenlevand organism es pued provocar largo plazo efecto negativo en el medio ambient acuático da kan forårsag uønsked langtidsvirkning vandmiljøet de kann gewässern längerfristig schädlich wirkungen haben el en long term advers effect aquat environ fr peut entraîn de effet néfast long term pour environn aquatiqu può provocar lungo termin effetti negativi ambient acquatico nl kan het aquatisch milieu op lang termijn schadelijk effecten veroorzaken pt pode causar efeito nefasto longo prazo ambient aquático fi voi aiheuttaa pitkäaikaisia haittavaikutuksia vesiympäristössä sv kan orsaka skadliga långtidseffekt vattenmiljön es tóxico para la flora da giftig planter de giftig für pflanzen el en toxic flora fr toxiqu pour la flore tossico la flora nl vergiftig voor planten pt tóxico para flora fi myrkyllistä kasveil sv giftigt för växter es tóxico para la fauna da giftig dyr de giftig für tier el en toxic fauna fr toxiqu pour la faun tossico la fauna nl vergiftig voor dieren pt tóxico para fauna fi myrkyllistä eläimil sv giftigt för djur es tóxico para lo organismo del suelo da giftig organism jordbunden de giftig für bodenorganismen el en toxic soil organ fr toxiqu pour le organism du sol tossico gli organismi del terreno nl vergiftig voor bodemorganismen pt tóxico para os organismo solo fi myrkyllistä maaperäeliöil sv giftigt för marklevand organism es tóxico para la abeja da giftig bier de giftig für bienen el en toxic bee fr toxiqu pour le abeil tossico le api nl vergiftig voor bijen pt tóxico para abelha fi myrkyllistä mehiläisil sv giftigt för bin es pued provocar largo plazo efecto negativo en el medio ambient da kan forårsag uønsked langtidsvirkning miljøet de kann längerfristig schädlich wirkungen auf die umwelt haben el en long term advers effect environ fr peut entraîn de effet néfast long term pour environn può provocar lungo termin effetti negativi ambient nl kan het milieu op lang termijn schadelijk effecten veroorzaken pt pode causar efeito nefasto longo prazo ambient fi voi aiheuttaa pitkäaikaisia haittavaikutuksia ympäristössä sv kan orsaka skadliga långtidseffekt miljön es peligroso para la capa de ozono da farlig ozonlaget de gefährlich für die ozonschicht el en danger ozon layer fr dangereux pour la couch ozon pericoloso lo strato di ozono nl gevaarlijk voor de ozonlaag pt perigoso para camada de ozono fi vaarallista otsonikerroksel sv farligt för ozonskiktet es pued perjudicar la fertilidad da kan skade forplantningsevnen de kann die fortpflanzungsfähigkeit beeinträchtigen el en impair fertil fr peut altérer la fertilité può ridurr la fertilità nl kan de vruchtbaarheid schaden pt pode compromet fertilidad fi voi heikentää hedelmällisyyttä sv kan ge nedsatt fortplantningsförmåga es riesgo durant el embarazo de efecto adverso para el feto da kan skade barnet graviditeten de kann da kind im mutterleib schädigen el en harm unborn child fr risqu pendant la grossess effet néfast pour enfant può danneggiar bambini ancora nati nl kan het ongeboren kind schaden pt risco durant gravidez efeito adverso na descendência fi vaarallista sikiöl sv kan ge fosterskador es posibl riesgo de perjudicar la fertilidad da muligh skade på forplantningsevnen de kann möglicherweis die fortpflanzungsfähigkeit beeinträchtigen el en risk impair fertil fr risqu altérat de la fertilité possibil rischio di ridotta fertilità nl mogelijk gevaar voor verminderd vruchtbaarheid pt possívei risco de compromet fertilidad fi voi mahdollisesti heikentää hedelmällisyyttä sv möjlig risk för nedsatt fortplantningsförmåga es posibl riesgo durant el embarazo de efecto adverso para el feto da muligh skade på barnet graviditeten de kann da kind im mutterleib möglicherweis schädigen el en risk harm unborn child fr risqu pendant la grossess effet néfast pour enfant possibil rischio di danni ai bambini ancora nati nl mogelijk gevaar voor beschadig van het ongeboren kind pt possívei risco durant gravidez efeito adverso na descendência fi voi olla vaarallista sikiöl sv möjlig risk för fosterskador es pued perjudicar lo niño alimentado con lech materna da kan skade børn ammeperioden de kann säugling über die muttermilch schädigen el en harm breastf babi fr risqu pour le bébé nourri au lait maternel possibil rischio bambini allattati al seno nl kan schadelijk zijn de borstvoed pt pode causar dano às criança alimentada leit materno fi saattaa aiheuttaa haittaa rintaruokinnassa olevil lapsil sv kan skada spädbarn amningsperioden es nocivo si se ingier pued causar daño pulmonar da farlig kan give lungeskad ved indtagels de gesundheitsschädlich kann beim verschlucken lungenschäden verursachen el en harm lung damag swallow fr nocif peut provoqu un atteint de poumon en ca ingest nocivo può causar danni ai polmoni caso di ingestion nl schadelijk kan longschad veroorzaken na verslikken pt nocivo pode causar dano no pulmõ se ingerido fi haitallista voi aiheuttaa keuhkovaurion nieltäessä sv farligt kan ge lungskador vid förtäring es la exposición repetida pued provocar sequedad formación de grieta en la piel da gentagen udsættels kan give tør eller revnet hud de wiederholt kontakt kann zu spröder oder rissig haut führen el en repeat exposur skin dryness crack fr exposit répétée peut provoqu dessèchement ou gerçur de la peau esposizion ripetuta può provocar secchezza screpolatur della pell nl herhaald blootstel kan een droge een gebarsten huid veroorzaken pt pode provocar secura da pele ou fissura por exposição repetida fi toistuva altistu voi aiheuttaa ihon kuivumista tai halkeilua sv upprepad kontakt kan ge torr hud eller hudsprickor es la inhalación de vapor pued provocar somnolencia vértigo da damp kan give sløvhed og svimmelh de dämpfe können schläfrigkeit und benommenheit verursachen el en vapour drowsi dizzi fr inhal de vapeur peut provoqu somnol vertig inalazion dei vapori può provocar sonnolenza vertigini nl dampen kunnen slaperigheid en duizeligheid veroorzaken pt pode provocar sonolência vertigen por inalação do vapor fi höyryt voivat aiheuttaa uneliaisuutta ja huimausta sv ångor kan göra att man blir dåsig och omtöcknad es posibilidad de efecto irrevers da muligh varig skade på helbr de irreversibl schaden möglich el en risk irrevers effect fr possibilité effet irrévers possibilità di effetti irreversibili nl onherstelbar effecten zijn niet uitgesloten pt possibilidad de efeito irreversívei fi pysyvien vaurioiden vaara sv möjlig risk för beståend hälsoskador combinación de frase kombin af sætninger kombin der sätze combin phrase combinaison de phrase combinazioni dell frasi combinati van zinnen combinação da frase yhdistetyt lausekkeet sammansatta fraser es reacciona violentament con el agua liberando gase extremadament inflam da reager voldsomt med vand dannels af yderst brandfarlig gasser de reagiert heftig mit wasser unter bildung hochentzündlich gase el en react violent water liber extrem flammabl gase fr réagit violem au contact de eau en dégageant de gaz extrêmement inflamm reagisc violentement con acqua liberando ga estremament infiammabili nl reageert heftig met water en vormt daarbij zeer ontvlambaar ga pt reag violentament água libertando gase extremament inflamávei fi reagoi voimakkaasti veden kanssa vapauttaen helposti syttyviä kaasuja sv reagerar häftigt med vatten varvid extremt brandfarliga gaser bilda es en contacto con el agua libera gase tóxico extremadament inflam da reager med vand dannels af giftig og yderst brandfarlig gasser de reagiert mit wasser unter bildung giftig und hochentzündlich gase el en contact water liber toxic extrem flammabl ga fr au contact de eau dégage de gaz toxiqu extrêmement inflamm contatto con acqua libera ga tossici ed estremament infiammabili nl vormt vergiftig en zeer ontvlambaar ga contact met water pt em contacto água liberta gase tóxico extremament inflamávei fi vapauttaa myrkyllisiä helposti syttyviä kaasuja veden kanssa sv utvecklar giftig och extremt brandfarlig ga vid kontakt med vatten es nocivo por inhalación en contacto con la piel da farlig ved indånd og ved hudkontakt de gesundheitsschädlich beim einatmen und bei berührung mit der haut el en harm inhal contact skin fr nocif par inhal par contact avec la peau nocivo inalazion contatto con la pell nl schadelijk bij inadem en bij aanrak met de huid pt nocivo por inalação em contacto pele fi terveydel haitallista hengitettynä ja joutuessaan ihol sv farligt vid inandn och hudkontakt es nocivo por inhalación por ingestión da farlig ved indånd og ved indtagels de gesundheitsschädlich beim einatmen und verschlucken el en harm inhal swallow fr nocif par inhal par ingest nocivo inalazion ingestion nl schadelijk bij inadem en opnam door de mond pt nocivo por inalação ingestão fi terveydel haitallista hengitettynä ja nieltynä sv farligt vid inandn och förtäring es nocivo por inhalación por ingestión en contacto con la piel da farlig ved indånd ved hudkontakt og ved indtagels de gesundheitsschädlich beim einatmen verschlucken und berührung mit der haut el en harm inhal contact skin swallow fr nocif par inhal par contact avec la peau par ingest nocivo inalazion contatto con la pell ingestion nl schadelijk bij inadem opnam door de mond en aanrak met de huid pt nocivo por inalação em contacto pele por ingestão fi terveydel haitallista hengitettynä joutuessaan ihol ja nieltynä sv farligt vid inandn hudkontakt och förtäring es nocivo en contacto con la piel por ingestión da farlig ved hudkontakt og ved indtagels de gesundheitsschädlich bei berührung mit der haut und beim verschlucken el en harm contact skin swallow fr nocif par contact avec la peau par ingest nocivo contatto con la pell ingestion nl schadelijk bij aanrak met de huid en bij opnam door de mond pt nocivo em contacto pele por ingestão fi terveydel haitallista joutuessaan ihol ja nieltynä sv farligt vid hudkontakt och förtäring es tóxico por inhalación en contacto con la piel da giftig ved indånd og ved hudkontakt de giftig beim einatmen und bei berührung mit der haut el en toxic inhal contact skin fr toxiqu par inhal par contact avec la peau tossico inalazion contatto con la pell nl vergiftig bij inadem en bij aanrak met de huid pt tóxico por inalação em contacto pele fi myrkyllistä hengitettynä ja joutuessaan ihol sv giftigt vid inandn och hudkontakt es tóxico por inhalación por ingestión da giftig ved indånd og ved indtagels de giftig beim einatmen und verschlucken el en toxic inhal swallow fr toxiqu par inhal par ingest tossico inalazion ingestion nl vergiftig bij inadem en opnam door de mond pt tóxico por inalação ingestão fi myrkyllistä hengitettynä ja nieltynä sv giftigt vid inandn och förtäring es tóxico por inhalación por ingestión en contacto con la piel da giftig ved indånd ved hudkontakt og ved indtagels de giftig beim einatmen verschlucken und berührung mit der haut el en toxic inhal contact skin swallow fr toxiqu par inhal par contact avec la peau par ingest tossico inalazion contatto con la pell ingestion nl vergiftig bij inadem opnam door de mond en aanrak met de huid pt tóxico por inalação em contacto pele por ingestão fi myrkyllistä hengitettynä joutuessaan ihol ja nieltynä sv giftigt vid inandn hudkontakt och förtäring es tóxico en contacto con la piel por ingestión da giftig ved hudkontakt og ved indtagels de giftig bei berührung mit der haut und beim verschlucken el en toxic contact skin swallow fr toxiqu par contact avec la peau par ingest tossico contatto con la pell ingestion nl vergiftig bij aanrak met de huid en bij opnam door de mond pt tóxico em contacto pele por ingestão fi myrkyllistä joutuessaan ihol ja nieltynä sv giftigt vid hudkontakt och förtäring es mui tóxico por inhalación en contacto con la piel da meget giftig ved indånd og ved hudkontakt de sehr giftig beim einatmen und bei berührung mit der haut el en toxic inhal contact skin fr trè toxiqu par inhal par contact avec la peau molto tossico inalazion contatto con la pell nl zeer vergiftig bij inadem en bij aanrak met de huid pt muito tóxico por inalação em contacto pele fi erittäin myrkyllistä hengitettynä ja joutuessaan ihol sv mycket giftigt vid inandn och hudkontakt es mui tóxico por inhalación por ingestión da meget giftig ved indånd og ved indtagels de sehr giftig beim einatmen und verschlucken el en toxic inhal swallow fr trè toxiqu par inhal par ingest molto tossico inalazion ingestion nl zeer vergiftig bij inadem en opnam door de mond pt muito tóxico por inalação ingestão fi erittäin myrkyllistä hengitettynä ja nieltynä sv mycket giftigt vid inandn och förtäring es mui tóxico por inhalación por ingestión en contacto con la piel da meget giftig ved indånd ved hudkontakt og ved indtagels de sehr giftig beim einatmen verschlucken und berührung mit der haut el en toxic inhal contact skin swallow fr trè toxiqu par inhal par contact avec la peau par ingest molto tossico inalazion contatto con la pell ingestion nl zeer vergiftig bij inadem opnam door de mond en aanrak met de huid pt muito tóxico por inalação em contacto pele por ingestão fi erittäin myrkyllistä hengitettynä joutuessaan ihol ja nieltynä sv mycket giftigt vid inandn hudkontakt och förtäring es mui tóxico en contacto con la piel por ingestión da meget giftig ved hudkontakt og ved indtagels de sehr giftig bei berührung mit der haut und beim verschlucken el en toxic contact skin swallow fr trè toxiqu par contact avec la peau par ingest molto tossico contatto con la pell ingestion nl zeer vergiftig bij aanrak met de huid en bij opnam door de mond pt muito tóxico em contacto pele por ingestão fi erittäin myrkyllistä joutuessaan ihol ja nieltynä sv mycket giftigt vid hudkontakt och förtäring es irrita lo ojo la vía respiratoria da irriter øjnene og åndedrætsorganern de reizt die augen und die atmungsorgan el en irrit ey respiratori system fr irrit pour le yeux le voi respiratoir irritant gli occhi le vie respiratori nl irriterend voor de ogen en de ademhalingswegen pt irritant para os olho via respiratória fi ärsyttää silmiä ja hengityselimiä sv irriterar ögonen och andningsorganen es irrita lo ojo la piel da irriter øjnene og huden de reizt die augen und die haut el en irrit ey skin fr irrit pour le yeux la peau irritant gli occhi la pell nl irriterend voor de ogen en de huid pt irritant para os olho pele fi ärsyttää silmiä ja ihoa sv irriterar ögonen och huden es irrita lo ojo la piel la vía respiratoria da irriter øjnene åndedrætsorganern og huden de reizt die augen die atmungsorgan und die haut el en irrit ey respiratori system skin fr irrit pour le yeux le voi respiratoir la peau irritant gli occhi le vie respiratori la pell nl irriterend voor de ogen de ademhalingswegen en de huid pt irritant para os olho via respiratória pele fi ärsyttää silmiä hengityselimiä ja ihoa sv irriterar ögonen andningsorganen och huden es irrita la vía respiratoria la piel da irriter åndedrætsorganern og huden de reizt die atmungsorgan und die haut el en irrit respiratori system skin fr irrit pour le voi respiratoir la peau irritant le vie respiratori la pell nl irriterend voor de ademhalingswegen en de huid pt irritant para via respiratória pele fi ärsyttää hengityselimiä ja ihoa sv irriterar andningsorganen och huden es tóxico peligro de efecto irrevers mui grave por inhalación da giftig fare varig alvorlig skade på helbr ved indånd de giftig ernst gefahr irreversiblen schaden durch einatmen el en toxic danger irrevers effect inhal fr toxiqu danger effet irrévers trè grave par inhal tossico pericolo di effetti irreversibili molto gravi inalazion nl vergiftig gevaar voor ernstig onherstelbar effecten bij inadem pt tóxico perigo de efeito irreversívei muito grave por inalação fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä sv giftigt risk för mycket allvarliga beståend hälsoskador vid inandn es tóxico peligro de efecto irrevers mui grave por contacto con la piel da giftig fare varig alvorlig skade på helbr ved hudkontakt de giftig ernst gefahr irreversiblen schaden bei berührung mit der haut el en toxic danger irrevers effect contact skin fr toxiqu danger effet irrévers trè grave par contact avec la peau tossico pericolo di effetti irreversibili molto gravi contatto con la pell nl vergiftig gevaar voor ernstig onherstelbar effecten bij aanrak met de huid pt tóxico perigo de efeito irreversívei muito grave em contacto pele fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara joutuessaan ihol sv giftigt risk för mycket allvarliga beståend hälsoskador vid hudkontakt es tóxico peligro de efecto irrevers mui grave por ingestión da giftig fare varig alvorlig skade på helbr ved indtagels de giftig ernst gefahr irreversiblen schaden durch verschlucken el en toxic danger irrevers effect swallow fr toxiqu danger effet irrévers trè grave par ingest tossico pericolo di effetti irreversibili molto gravi ingestion nl vergiftig gevaar voor ernstig onherstelbar effecten bij opnam door de mond pt tóxico perigo de efeito irreversívei muito grave por ingestão fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara nieltynä sv giftigt risk för mycket allvarliga beståend hälsoskador vid förtäring es tóxico peligro de efecto irrevers mui grave por inhalación contacto con la piel da giftig fare varig alvorlig skade på helbr ved indånd og hudkontakt de giftig ernst gefahr irreversiblen schaden durch einatmen und bei berührung mit der haut el en toxic danger irrevers effect inhal contact skin fr toxiqu danger effet irrévers trè grave par inhal par contact avec la peau tossico pericolo di effetti irreversibili molto gravi inalazion contatto con la pell nl vergiftig gevaar voor ernstig onherstelbar effecten bij inadem en aanrak met de huid pt tóxico perigo de efeito irreversívei muito grave por inalação em contacto pele fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä ja joutuessaan ihol sv giftigt risk för mycket allvarliga beståend hälsoskador vid inandn och hudkontakt es tóxico peligro de efecto irrevers mui grave por inhalación ingestión da giftig fare varig alvorlig skade på helbr ved indånd og indtagels de giftig ernst gefahr irreversiblen schaden durch einatmen und durch verschlucken el en toxic danger irrevers effect inhal swallow fr toxiqu danger effet irrévers trè grave par inhal par ingest tossico pericolo di effetti irreversibili molto gravi inalazion ingestion nl vergiftig gevaar voor ernstig onherstelbar effecten bij inadem en opnam door de mond pt tóxico perigo de efeito irreversívei muito grave por inalação ingestão fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä ja nieltynä sv giftigt risk för mycket allvarliga beståend hälsoskador vid inandn och förtäring es tóxico peligro de efecto irrevers mui grave por contacto con la piel ingestión da giftig fare varig alvorlig skade på helbr ved hudkontakt og indtagels de giftig ernst gefahr irreversiblen schaden bei berührung mit der haut und durch verschlucken el en toxic danger irrevers effect contact skin swallow fr toxiqu danger effet irrévers trè grave par contact avec la peau par ingest tossico pericolo di effetti irreversibili molto gravi contatto con la pell ingestion nl vergiftig gevaar voor ernstig onherstelbar effecten bij aanrak met de huid en opnam door de mond pt tóxico perigo de efeito irreversívei muito grave em contacto pele por ingestão fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara joutuessaan ihol ja nieltynä sv giftigt risk för mycket allvarliga beståend hälsoskador vid hudkontakt och förtäring es tóxico peligro de efecto irrevers mui grave por inhalación contacto con la piel ingestión da giftig fare varig alvorlig skade på helbr ved indånd hudkontakt og indtagels de giftig ernst gefahr irreversiblen schaden durch einatmen berührung mit der haut und durch verschlucken el en toxic danger irrevers effect inhal contact skin swallow fr toxiqu danger effet irrévers trè grave par inhal par contact avec la peau par ingest tossico pericolo di effetti irreversibili molto gravi inalazion contatto con la pell ingestion nl vergiftig gevaar voor ernstig onherstelbar effecten bij inadem aanrak met de huid en opnam door de mond pt tóxico perigo de efeito irreversívei muito grave por inalação em contacto pele por ingestão fi myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä joutuessaan ihol ja nieltynä sv giftigt risk för mycket allvarliga beståend hälsoskador vid inandn hudkontakt och förtäring es mui tóxico peligro de efecto irrevers mui grave por inhalación da meget giftig fare varig alvorlig skade på helbr ved indånd de sehr giftig ernst gefahr irreversiblen schaden durch einatmen el en toxic danger irrevers effect inhal fr trè toxiqu danger effet irrévers trè grave par inhal molto tossico pericolo di effetti irreversibili molto gravi inalazion nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij inadem pt muito tóxico perigo de efeito irreversívei muito grave por inalação fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid inandn es mui tóxico peligro de efecto irrevers mui grave por contacto con la piel da meget giftig fare varig alvorlig skade på helbr ved hudkontakt de sehr giftig ernst gefahr irreversiblen schaden bei berührung mit der haut el en toxic danger irrevers effect contact skin fr trè toxiqu danger effet irrévers trè grave par contact avec la peau molto tossico pericolo di effetti irreversibili molto gravi contatto con la pell nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij aanrak met de huid pt muito tóxico perigo de efeito irreversívei muito grave em contacto pele fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara joutuessaan ihol sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid hudkontakt es mui tóxico peligro de efecto irrevers mui grave por ingestión da meget giftig fare varig alvorlig skade på helbr ved indtagels de sehr giftig ernst gefahr irreversiblen schaden durch verschlucken el en toxic danger irrevers effect swallow fr trè toxiqu danger effet irrévers trè grave par ingest molto tossico pericolo di effetti irreversibili molto gravi ingestion nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij opnam door de mond pt muito tóxico perigo de efeito irreversívei muito grave por ingestão fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara nieltynä sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid förtäring es mui tóxico peligro de efecto irrevers mui grave por inhalación contacto con la piel da meget giftig fare varig alvorlig skade på helbr ved indånd og hudkontakt de sehr giftig ernst gefahr irreversiblen schaden durch einatmen und bei berührung mit der haut el en toxic danger irrevers effect inhal contact skin fr trè toxiqu danger effet irrévers trè grave par inhal par contact avec la peau molto tossico pericolo di effetti irreversibili molto gravi inalazion contatto con la pell nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij inadem en aanrak met de huid pt muito tóxico perigo de efeito irreversívei muito grave por inalação em contacto pele fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä ja joutuessaan ihol sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid inandn och hudkontakt es mui tóxico peligro de efecto irrevers mui grave por inhalación ingestión da meget giftig fare varig alvorlig skade på helbr ved indånd og indtagels de sehr giftig ernst gefahr irreversiblen schaden durch einatmen und durch verschlucken el en toxic danger irrevers effect inhal swallow fr trè toxiqu danger effet irrévers trè grave par inhal par ingest molto tossico pericolo di effetti irreversibili molto gravi inalazion ingestion nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij inadem en opnam door de mond pt muito tóxico perigo de efeito irreversívei muito grave por inalação ingestão fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä ja nieltynä sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid inandn och förtäring es mui tóxico peligro de efecto irrevers mui grave por contacto con la piel ingestión da meget giftig fare varig alvorlig skade på helbr ved hudkontakt og indtagels de sehr giftig ernst gefahr irreversiblen schaden bei berührung mit der haut und durch verschlucken el en toxic danger irrevers effect contact skin swallow fr trè toxiqu danger effet irrévers trè grave par contact avec la peau par ingest molto tossico pericolo di effetti irreversibili molto gravi contatto con la pell ingestion nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij aanrak met de huid en opnam door de mond pt muito tóxico perigo de efeito irreversívei muito grave em contacto pele por ingestão fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara joutuessaan ihol ja nieltynä sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid hudkontakt och förtäring es mui tóxico peligro de efecto irrevers mui grave por inhalación contacto con la piel ingestión da meget giftig fare varig alvorlig skade på helbr ved indånd hudkontakt og indtagels de sehr giftig ernst gefahr irreversiblen schaden durch einatmen berührung mit der haut und durch verschlucken el en toxic danger irrevers effect inhal contact skin swallow fr trè toxiqu danger effet irrévers trè grave par inhal par contact avec la peau par ingest molto tossico pericolo di effetti irreversibili molto gravi inalazion contatto con la pell ingestion nl zeer vergiftig gevaar voor ernstig onherstelbar effecten bij inadem aanrak met de huid en opnam door de mond pt muito tóxico perigo de efeito irreversívei muito grave por inalação em contacto pele por ingestão fi erittäin myrkyllistä erittäin vakavien pysyvien vaurioiden vaara hengitettynä joutuessaan ihol ja nieltynä sv mycket giftigt risk för mycket allvarliga beståend hälsoskador vid inandn hudkontakt och förtäring es posibilidad de sensibilización por inhalación por contacto con la piel da kan give overfølsomh ved indånd og ved kontakt med huden de sensibilisierung durch einatmen und hautkontakt möglich el en sensitis inhal skin contact fr peut entraîn un sensibilis par inhal par contact avec la peau può provocar sensibilizzazion inalazion contatto con la pell nl kan overgevoeligheid veroorzaken bij inadem contact met de huid pt pode causar sensibilização por inalação em contacto pele fi altistuminen hengitysteits ja ihokosketu voi aiheuttaa herkistymistä sv kan ge allergi vid inandn och hudkontakt es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación da farlig alvorlig sundhedsfar ved længere tid påvirkn ved indånd de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen el en harm danger damag health prolong exposur inhal fr nocif risqu effet grave pour la santé en ca exposit prolongé par inhal nocivo pericolo di gravi danni la salut caso di esposizion prolungata inalazion nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem pt nocivo risco de efeito grave para saúd em caso de exposição prolongada por inalação fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä sv farligt risk för allvarliga hälsoskador vid långvarig expon genom inandn es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por contacto con la piel da farlig alvorlig sundhedsfar ved længere tid påvirkn ved hudkontakt de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch berührung mit der haut el en harm danger damag health prolong exposur contact skin fr nocif risqu effet grave pour la santé en ca exposit prolongé par contact avec la peau nocivo pericolo di gravi danni alla salut caso di esposizion prolungata contatto con la pell nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij aanrak met de huid pt nocivo risco de efeito grave para saúd em caso de exposição prolongada em contacto pele fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel joutuessaan ihol sv farligt risk för allvarliga hälsoskador vid långvarig expon genom hudkontakt es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por ingestión da farlig alvorlig sundhedsfar ved længere tid påvirkn ved indtagels de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch verschlucken el en harm danger damag health prolong exposur swallow fr nocif risqu effet grave pour la santé en ca exposit prolongé par ingest nocivo pericolo di gravi danni alla salut caso di esposizion prolungata ingestion nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij opnam door de mond pt nocivo risco de efeito grave para saúd em caso de exposição prolongada por ingestão fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel nieltynä sv farligt risk för allvarliga hälsoskador vid långvarig expon genom förtäring es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación contacto con la piel da farlig alvorlig sundhedsfar ved længere tid påvirkn ved indånd og hudkontakt de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen und durch berührung mit der haut el en harm danger damag health prolong exposur inhal contact skin fr nocif risqu effet grave pour la santé en ca exposit prolongé par inhal par contact avec la peau nocivo pericolo di gravi danni alla salut caso di esposizion prolungata inalazion contatto con la pell nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem en aanrak met de huid pt nocivo risco de efeito grave para saúd em caso de exposição prolongada por inalação em contacto pele fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä ja joutuessaan ihol sv farligt risk för allvarliga hälsoskador vid långvarig expon genom inandn och hudkontakt es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación ingestión da farlig alvorlig sundhedsfar ved længere tid påvirkn ved indånd og indtagels de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen und durch verschlucken el en harm danger damag health prolong exposur inhal swallow fr nocif risqu effet grave pour la santé en ca exposit prolongé par inhal par ingest nocivo pericolo di gravi danni alla salut caso di esposizion prolungata inalazion ingestion nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem en opnam door de mond pt nocivo risco de efeito grave para saúd em caso de exposição prolongada por inalação ingestão fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä ja nieltynä sv farligt risk för allvarliga hälsoskador vid långvarig expon genom inandn och förtäring es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por contacto con la piel ingestión da farlig alvorlig sundhedsfar ved længere tid påvirkn ved hudkontakt og indtagels de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch berührung mit der haut und durch verschlucken el en harm danger damag health prolong exposur contact skin swallow fr nocif risqu effet grave pour la santé en ca exposit prolongé par contact avec la peau par ingest nocivo pericolo di gravi danni alla salut caso di esposizion prolungata contatto con la pell ingestion nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij aanrak met de huid en opnam door de mond pt nocivo risco de efeito grave para saúd em caso de exposição prolongada em contacto pele por ingestão fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel joutuessaan ihol ja nieltynä sv farligt risk för allvarliga hälsoskador vid långvarig expon genom hudkontakt och förtäring es nocivo riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación contacto con la piel ingestión da farlig alvorlig sundhedsfar ved længere tid påvirkn ved indånd hudkontakt og indtagels de gesundheitsschädlich gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen berührung mit der haut und durch verschlucken el en harm danger damag health prolong exposur inhal contact skin swallow fr nocif risqu effet grave pour la santé en ca exposit prolongé par inhal par contact avec la peau par ingest nocivo pericolo di gravi danni alla salut caso di esposizion prolungata inalazion contatto con la pell ingestion nl schadelijk gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem aanrak met de huid en opnam door de mond pt nocivo risco de efeito grave para saúd em caso de exposição prolongada por inalação em contacto pele por ingestão fi terveydel haitallista pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä joutuessaan ihol ja nieltynä sv farligt risk för allvarliga hälsoskador vid långvarig expon genom inandn hudkontakt och förtäring es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación da giftig alvorlig sundhedsfar ved længere tid påvirkn ved indånd de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen el en toxic danger damag health prolong exposur inhal fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par inhal tossico pericolo di gravi danni alla salut caso di esposizion prolungata inalazion nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem pt tóxico risco de efeito grave para saúd em caso de exposição prolongada por inalação fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom inandn es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por contacto con la piel da giftig alvorlig sundhedsfar ved længere tid påvirkn ved hudkontakt de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch berührung mit der haut el en toxic danger damag health prolong exposur contact skin fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par contact avec la peau tossico pericolo di gravi danni alla salut caso di esposizion prolungata contatto con la pell nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij aanrak met de huid pt tóxico risco de efeito grave para saúd em caso de exposição prolongada em contacto pele fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel joutuessaan ihol sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom hudkontakt es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por ingestión da giftig alvorlig sundhedsfar ved længere tid påvirkn ved indtagels de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch verschlucken el en toxic danger damag health prolong exposur swallow fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par ingest tossico pericolo di gravi danni alla salut caso di esposizion prolungata ingestion nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij opnam door de mond pt tóxico risco de efeito grave para saúd em caso de exposição prolongada por ingestão fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel nieltynä sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom förtäring es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación contacto con la piel da giftig alvorlig sundhedsfar ved længere tid påvirkn ved indånd og hudkontakt de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen und durch berührung mit der haut el en toxic danger damag health prolong exposur inhal contact skin fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par inhal par contact avec la peau tossico pericolo di gravi danni alla salut caso di esposizion prolungata inalazion contatto con la pell nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem en aanrak met de huid pt tóxico risco de efeito grave para saúd em caso de exposição prolongada por inalação em contacto pele fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä ja joutuessaan ihol sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom inandn och hudkontakt es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación ingestión da giftig alvorlig sundhedsfar ved længere tid påvirkn ved indånd og indtagels de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen und durch verschlucken el en toxic danger damag health prolong exposur inhal swallow fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par inhal par ingest tossico pericolo di gravi danni alla salut caso di esposizion prolungata inalazion ed ingestion nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem en opnam door de mond pt tóxico risco de efeito grave para saúd em caso de exposição prolongada por inalação ingestão fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä ja nieltynä sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom inandn och förtäring es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por contacto con la piel ingestión da giftig alvorlig sundhedsfar ved længere tid påvirkn ved hudkontakt og indtagels de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch berührung mit der haut und durch verschlucken el en toxic danger damag health prolong exposur contact skin swallow fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par contact avec la peau par ingest tossico pericolo di gravi danni alla salut caso di esposizion prolungata contatto con la pell ingestion nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij aanrak met de huid en opnam door de mond pt tóxico risco de efeito grave para saúd em caso de exposição prolongada em contacto pele por ingestão fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel joutuessaan ihol ja nieltynä sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom hudkontakt och förtäring es tóxico riesgo de efecto grave para la salud en caso de exposición prolongada por inhalación contacto con la piel ingestión da giftig alvorlig sundhedsfar ved længere tid påvirkn ved indånd hudkontakt og indtagels de giftig gefahr ernster gesundheitsschäden bei längerer exposit durch einatmen berührung mit der haut und durch verschlucken el en toxic danger damag health prolong exposur inhal contact skin swallow fr toxiqu risqu effet grave pour la santé en ca exposit prolongé par inhal par contact avec la peau par ingest tossico pericolo di gravi danni alla salut caso di esposizion prolungata inalazion contatto con la pell ingestion nl vergiftig gevaar voor ernstig schade aan de gezondheid bij langdurig blootstel bij inadem aanrak met de huid en opnam door de mond pt tóxico risco de efeito grave para saúd em caso de exposição prolongada por inalação em contacto pele por ingestão fi myrkyllistä pitkäaikainen altistu voi aiheuttaa vakavaa haittaa terveydel hengitettynä joutuessaan ihol ja nieltynä sv giftigt risk för allvarliga hälsoskador vid långvarig expon genom inandn hudkontakt och förtäring es mui tóxico para lo organismo acuático pued provocar largo plazo efecto negativo en el medio ambient acuático da meget giftig organism der lever vand kan forårsag uønsked langtidsvirkning vandmiljøet de sehr giftig für wasserorganismen kann gewässern längerfristig schädlich wirkungen haben el en toxic aquat organ long term advers effect aquat environ fr trè toxiqu pour le organism aquatiqu peut entraîn de effet néfast long term pour environn aquatiqu altament tossico gli organismi acquatici può provocar lungo termin effetti negativi ambient acquatico nl zeer vergiftig voor het water levend organismen kan het aquatisch milieu op lang termijn schadelijk effecten veroorzaken pt muito tóxico para os organismo aquático podendo causar efeito nefasto longo prazo ambient aquático fi erittäin myrkyllistä vesieliöil voi aiheuttaa pitkäaikaisia haittavaikutuksia vesiympäristössä sv mycket giftigt för vattenlevand organism kan orsaka skadliga långtidseffekt vattenmiljön es tóxico para lo organismo acuático pued provocar largo plazo efecto negativo en el medio ambient acuático da giftig organism der lever vand kan forårsag uønsked langtidsvirkning vandmiljøet de giftig für wasserorganismen kann gewässern längerfristig schädlich wirkungen haben el en toxic aquat organ long term advers effect aquat environ fr toxiqu pour le organism aquatiqu peut entraîn de effet néfast long term pour environn aquatiqu tossico gli organismi acquatici può provocar lungo termin effetti negativi ambient acquatico nl vergiftig voor het water levend organismen kan het aquatisch milieu op lang termijn schadelijk effecten veroorzaken pt tóxico para os organismo aquático podendo causar efeito nefasto longo prazo ambient aquático fi myrkyllistä vesieliöil voi aiheuttaa pitkäaikaisia haittavaikutuksia vesiympäristössä sv giftigt för vattenlevand organism kan orsaka skadliga långtidseffekt vattenmiljön es nocivo para lo organismo acuático pued provocar largo plazo efecto negativo en el medio ambient acuático da skadelig organism der lever vand kan forårsag uønsked langtidsvirkning vandmiljøet de schädlich für wasserorganismen kann gewässern längerfristig schädlich wirkungen haben el en harm aquat organ long term advers effect aquat environ fr nocif pour le organism aquatiqu peut entraîn de effet néfast long term pour environn aquatiqu nocivo gli organismi acquatici può provocar lungo termin effetti negativi ambient acquatico nl schadelijk voor het water levend organismen kan het aquatisch milieu op lang termijn schadelijk effecten veroorzaken pt nocivo para os organismo aquático podendo causar efeito nefasto longo prazo ambient aquático fi haitallista vesieliöil voi aiheuttaa pitkäaikaisia haittavaikutuksia vesiympäristössä sv skadligt för vattenlevand organism kan orsaka skadliga långtidseffekt vattenmiljön es nocivo posibilidad de efecto irrevers por inhalación da farlig muligh varig skade på helbr ved indånd de gesundheitsschädlich möglichkeit irreversiblen schaden durch einatmen el en harm risk irrevers effect inhal fr nocif possibilité effet irrévers par inhal nocivo possibilità di effetti irreversibili inalazion nl schadelijk bij inadem zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei por inalação fi terveydel haitallista pysyvien vaurioiden vaara hengitettynä sv farligt möjlig risk för beståend hälsoskador vid inandn es nocivo posibilidad de efecto irrevers por contacto con la piel da farlig muligh varig skade på helbr ved hudkontakt de gesundheitsschädlich möglichkeit irreversiblen schaden bei berührung mit der haut el en harm risk irrevers effect contact skin fr nocif possibilité effet irrévers par contact avec la peau nocivo possibilità di effetti irreversibili contatto con la pell nl schadelijk bij aanrak met de huid zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei em contacto pele fi terveydel haitallista pysyvien vaurioiden vaara joutuessaan ihol sv farligt möjlig risk för beståend hälsoskador vid hudkontakt es nocivo posibilidad de efecto irrevers por ingestión da farlig muligh varig skade på helbr ved indtagels de gesundheitsschädlich möglichkeit irreversiblen schaden durch verschlucken el en harm risk irrevers effect swallow fr nocif possibilité effet irrévers par ingest nocivo possibilità di effetti irreversibili ingestion nl schadelijk bij opnam door de mond zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei por ingestão fi terveydel haitallista pysyvien vaurioiden vaara nieltynä sv farligt möjlig risk för beståend hälsoskador vid förtäring es nocivo posibilidad de efecto irrevers por inhalación contacto con la piel da farlig muligh varig skade på helbr ved indånd og hudkontakt de gesundheitsschädlich möglichkeit irreversiblen schaden durch einatmen und bei berührung mit der haut el en harm risk irrevers effect inhal contact skin fr nocif possibilité effet irrévers par inhal par contact avec la peau nocivo possibilità di effetti irreversibili inalazion contatto con la pell nl schadelijk bij inadem en aanrak met de huid zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei por inalação em contacto pele fi terveydel haitallista pysyvien vaurioiden vaara hengitettynä ja joutuessaan ihol sv farligt möjlig risk för beståend hälsoskador vid inandn och hudkontakt es nocivo posibilidad de efecto irrevers por inhalación ingestión da farlig muligh varig skade på helbr ved indånd og indtagels de gesundheitsschädlich möglichkeit irreversiblen schaden durch einatmen und durch verschlucken el en harm risk irrevers effect inhal swallow fr nocif possibilité effet irrévers par inhal par ingest nocivo possibilità di effetti irreversibili inalazion ingestion nl schadelijk bij inadem en opnam door de mond zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei por inalação ingestão fi terveydel haitallista pysyvien vaurioiden vaara hengitettynä ja nieltynä sv farligt möjlig risk för beståend hälsoskador vid inandn och förtäring es nocivo posibilidad de efecto irrevers por contacto con la piel ingestión da farlig muligh varig skade på helbr ved hudkontakt og indtagels de gesundheitsschädlich möglichkeit irreversiblen schaden bei berührung mit der haut und durch verschlucken el en harm risk irrevers effect contact skin swallow fr nocif possibilité effet irrévers par contact avec la peau par ingest nocivo possibilità di effetti irreversibili contatto con la pell ingestion nl schadelijk bij aanrak met de huid en opnam door de mond zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei em contacto pele por ingestão fi terveydel haitallista pysyvien vaurioiden vaara joutuessaan ihol ja nieltynä sv farligt möjlig risk för beståend hälsoskador vid hudkontakt och förtäring es nocivo posibilidad de efecto irrevers por inhalación contacto con la piel ingestión da farlig muligh varig skade på helbr ved indånd hudkontakt og indtagels de gesundheitsschädlich möglichkeit irreversiblen schaden durch einatmen berührung mit der haut und durch verschlucken el en harm risk irrevers effect inhal contact skin swallow fr nocif possibilité effet irrévers par inhal par contact avec la peau par ingest nocivo possibilità di effetti irreversibili inalazion contatto con la pell ingestion nl schadelijk bij inadem aanrak met de huid en opnam door de mond zijn onherstelbar effecten niet uitgesloten pt nocivo possibilidad de efeito irreversívei por inalação em contacto pele por ingestão fi terveydel haitallista pysyvien vaurioiden vaara hengitettynä joutuessaan ihol ja nieltynä sv farligt möjlig risk för beståend hälsoskador vid inandn hudkontakt och förtäring annex anexo iv bilag iv anhang iv iv annex iv annex iv allegato iv bijlag iv anexo iv liit iv bilaga iv anexo iv consejo de prudencia relativo la sustancia preparado peligroso bilag iv forsigtighedsregl farlig stoffer og præparat anhang iv sicherheitsratschläg für gefährlich stoff und zubereitungen iv annex iv safeti advic danger substanc prepar annex iv conseil de prudenc concern le substanc préparat dangereus allegato iv consigli di prudenza riguardanti le sostanz preparati pericolosi bijlag iv veiligheidsaanbevelingen met betrek tot gevaarlijk stoffen en preparaten anexo iv conselho de prudência relativo substância preparaçõ perigosa liit iv vaarallisten aineiden ja valmisteiden turvallisuusohjeet bilaga iv skyddsfras för farliga ämnen och beredningar es consérves bajo llave da opbevar lå de unter verschluss aufbewahren el en lock fr conserv sou clé conservar sotto chiav nl achter slot bewaren pt guardar fechado chave fi säilytettävä lukitussa tilassa sv förvara låst utrymm es manténgas fuera del alcanc de lo niño da opbevar utilgængeligt børn de darf nicht die hände von kindern gelangen el en reach children fr conserv hor de porté de enfant conservar fuori della portata dei bambini nl buiten bereik van kinderen bewaren pt manter fora alcanc da criança fi säilytettävä lasten ulottumattomissa sv förvara oåtkomligt för barn es consérves en lugar fresco da opbevar køligt de kühl aufbewahren el en cool place fr conserv dan endroit frai conservar luogo fresco nl op een koel plaat bewaren pt guardar em lugar fresco fi säilytettävä viileässä sv förvara svalt es manténgas lejo de local habitado da må ikk opbevar nærheden af beboels de von wohnplätzen fernhalten el en live quarter fr conserv écart de tout local habit conservar lontano da locali di abitazion nl verwijderd van woonruimten opbergen pt manter fora de qualquer zona de habitação fi ei saa säilyttää asuintiloissa sv förvara avskilt från bostadsutrymmen es consérves en líquido apropiado especificar por el fabricant da opbevar en egnet væske som angiv af fabrikanten de unter aufbewahren geeignet flüssigkeit vom herstel anzugeben el en content liquid manufactur fr conserv sou liquid approprié spécifier par le fabric conservar sotto liquido appropriato da indicarsi da part del fabbricant nl onder houden geschikt vloeistof aan te geven door fabrik pt manter sob líquido apropriado especificar pelo produtor fi sisältö säilytettävä tarkoitukseen soveltuvan nesteen ilmoittaa valmistaja maahantuoja sv förvara innehållet lämplig vätska ang av tillverkaren es consérves en ga inert especificar por el fabricant da opbevar en inaktiv ga som angiv af fabrikanten de unter aufbewahren inert ga vom herstel anzugeben el en inert ga manufactur fr conserv sou gaz inert spécifier par le fabric conservar sotto ga inert da indicarsi da part del fabbricant nl onder houden inert ga aan te geven door fabrik pt manter sob gá inert especificar pelo produtor fi säilytettävä inertin kaasun ilmoittaa valmistaja maahantuoja sv förvara inert ga ang av tillverkaren es manténgas el recipient bien cerrado da emballagen skal hold tæt lukket de behälter dicht geschlossen halten el en contain tightli close fr conserv le récipient bien fermé conservar il recipient ben chiuso nl go gesloten verpak bewaren pt manter recipient bem fechado fi säilytettävä tiiviisti suljettuna sv förpackningen förvara väl tillsluten es manténgas el recipient en lugar seco da emballagen skal opbevar tørt de behälter trocken halten el en contain dry fr conserv le récipient abri de humidité conservar al riparo dall umidità nl verpak droog houden pt manter recipient ao abrigo da humidad fi säilytettävä kuivana sv förpackningen förvara torrt es consérves el recipient en lugar bien ventilado da emballagen skal opbevar på godt ventileret sted de behälter einem gut gelüfteten ort aufbewahren el en contain ventil place fr conserv le récipient dan endroit bien ventilé conservar il recipient luogo ben ventilato nl op een go geventileerd plaat bewaren pt manter recipient num local bem ventilado fi säilytettävä paikassa jossa hyvä ilmanvaihto sv förpackningen förvara på väl ventilerad plat es cerrar el recipient herméticament da emballagen må ikk lukk tæt de behälter nicht gasdicht verschließen el en contain seal fr ne pa fermer hermétiqu le récipient chiuder ermeticament il recipient nl de verpak niet hermetisch sluiten pt não fechar recipient hermeticament fi pakkausta ei saa sulkea ilmatiiviisti sv förpackningen får int tillsluta lufttätt es manténgas lejo de alimento bebida pienso da må ikk opbevar sammen med fødevar drikkevar og foderstoff de von nahrungsmitteln getränken und futtermitteln fernhalten el en food drink anim feedingstuff fr conserv écart de aliment boisson compri ceux pour animaux conservar lontano da alimenti mangimi da bevand nl verwijderd houden van eet en drinkwaren en van diervoed pt manter afastado de alimento bebida incluindo os do animai fi ei saa säilyttää yhdessä elintarvikkeiden eikä eläinravinnon kanssa sv förvara åtskilt från livsmedel och djurfod es consérves lejo de material incompat especificar por el fabricant da opbevar adskilt fra uforligelig stoffer som angiv af fabrikanten de von fernhalten inkompat substanzen sind vom herstel anzugeben el en incompat materi manufactur fr conserv écart de matièr incompat indiqu par le fabric conservar lontano da sostanz incompatibili da precisar da part del produttor nl verwijderd houden van stoffen waarme contact vermeden dient te worden aan te geven door de fabrik pt manter afastado de matéria incompatívei indicar pelo produtor fi säilytettävä erillään yhteensopimattomat aineet ilmoittaa valmistaja maahantuoja sv förvara åtskilt från oförenliga ämnen ang av tillverkaren es conservar alejado del calor da må ikk udsætt varm de vor hitz schützen el en heat fr conserv écart de la chaleur conservar lontano dal calor nl verwijderd houden van warmt pt manter afastado calor fi suojattava lämmöltä sv får int utsätta för värme es conservar alejado de toda llama fuent de chispa fumar da hold væk fra antændelseskild rygn forbudt de von zündquellen fernhalten nicht rauchen el en sourc ignit smoke fr conserv écart de tout flamm ou sourc étincel ne pa fumer conservar lontano da fiamm scintil fumar nl verwijderd houden van ontstekingsbronnen niet roken pt manter afastado de qualquer chama ou font de ignição não fumar fi eristettävä sytytyslähteistä tupakointi kielletti sv förvara åtskilt från antändningskällor rökning förbjuden es manténgas lejo de materia combust da hold væk fra brandbar stoffer de von brennbaren stoffen fernhalten el en combust materi fr tenir écart de matièr combust tener lontano da sostanz combustibili nl verwijderd houden van brandbar stoffen pt manter afastado de matéria combustívei fi säilytettävä erillään syttyvistä kemikaaleista sv förvara åtskilt från brandfarliga ämnen es manipúles ábrase el recipient con prudencia da emballagen skal behandl og åbne med forsigtigh de behälter mit vorsicht öffnen und handhaben el en handl open contain care fr manipul ouvrir le récipient avec prudenc manipolar ed aprir il recipient con cautela nl verpak voorzichtig behandelen en openen pt manipular abrir recipient prudência fi pakkauksen käsittelyssä ja avaamisessa noudatettava varovaisuutta sv förpackningen hantera och öppna försiktigt es comer ni beber durant su utilización da der må ikk spise eller drikk brugen de bei der arbeit nicht essen und trinken el en eat drink fr ne pa manger ne pa boir pendant utilis mangiar né bere durant impiego nl niet eten drinken tijden gebruik pt não comer nem beber durant utilização fi syöminen ja juominen kielletti kemikaalia käsiteltäessä sv ät int eller drick int hanteringen es fumar durant su utilización da der må ikk ryge brugen de bei der arbeit nicht rauchen el en smoke fr ne pa fumer pendant utilis fumar durant impiego nl niet roken tijden gebruik pt não fumar durant utilização fi tupakointi kielletti kemikaalia käytettäessä sv rök int hanteringen es respirar el polvo da undgå indånd af støv de staub nicht einatmen el en breath dust fr ne pa respir le poussièr respirar le polveri nl stof niet inademen pt não respirar poeira fi vältettävä pölyn hengittämistä sv undvik inandn av damm es respirar lo gase humo vapor aerosol denominación es adecuada especificar por el fabricant da undgå indånd af ga røg damp aerosol tåger den eller de pågældend betegnels angiv af fabrikanten de ga rauch dampf aerosol nicht einatmen geeignet bezeichnung en vom herstel anzugeben el en breath ga fume vapour sprai word manufactur fr ne pa respir le gaz fumé vapeur aérosol term approprié indiqu par le fabric respirar ga fumi vapori aerosoli termin appropriato da precisar da part del produttor nl ga rook damp spuitnevel niet inademen toepasselijk term en aan te geven door de fabrik pt não respirar os gase vapor fumo aerossói termo apropriado indicar pelo produtor fi vältettävä kaasun huurun höyryn sumun hengittämistä oikean sanamuodon valitse valmistaja maahantuoja sv undvik inandn av ga rök ånga dimma lämplig formul ang av tillverkaren es evítes el contacto con la piel da undgå kontakt med huden de berührung mit der haut vermeiden el en avoid contact skin fr éviter le contact avec la peau evitar il contatto con la pell nl aanrak met de huid vermijden pt evitar contacto pele fi varottava kemikaalin joutumista ihol sv undvik kontakt med huden es evítes el contacto con lo ojo da undgå kontakt med øjnene de berührung mit den augen vermeiden el en avoid contact ey fr éviter le contact avec le yeux evitar il contatto con gli occhi nl aanrak met de ogen vermijden pt evitar contacto os olho fi varottava kemikaalin joutumista silmiin sv undvik kontakt med ögonen es en caso de contacto con lo ojo lávens inmediata abundantement con agua acúdas médico da kommer stoffet øjnene skyll strak grundigt med vand og læge kontakt de bei berührung mit den augen sofort gründlich mit wasser abspülen und arzt konsultieren el en case contact ey rins immedi plenti water seek medic advic fr en ca de contact avec le yeux laver immédiat abondam avec de eau consult spécialist caso di contatto con gli occhi lavar immediatament abbondantement con acqua consultar medico nl bij aanrak met de ogen onmiddellijk met overvloedig water afspoelen en deskundig medisch advi inwinnen pt em caso de contacto os olho lavar imediata abundantement água consultar um especialista fi roiskeet silmistä huuhdeltava välittömästi runsaalla vedellä ja mentävä lääkäriin sv vid kontakt med ögonen spola genast med mycket vatten och kontakta läkare es quítes inmediatament la ropa manchada salpicada da tilsmudset tøj tage strak af de beschmutzt getränkt kleidung sofort ausziehen el en immedi contamin cloth fr enlev immédiat tout vêtement souillé ou éclaboussé togliersi di dosso immediatament gli indumenti contaminati nl verontreinigd klede onmiddellijk uittrekken pt retirar imediatament todo vestuário contaminado fi riisuttava välittömästi saastunut vaatetu sv tag genast av alla nedstänkta kläder es en caso de contacto con la piel lávese inmediata abundantement con producto especificar por el fabricant da kommer stof på huden vask strak med store mængder angiv af fabrikanten de bei berührung mit der haut sofort abwaschen mit viel vom herstel anzugeben el en contact skin wash immedi plenti manufactur fr aprè contact avec la peau se laver immédiat abondam avec produit approprié indiqu par le fabric caso di contatto con la pell lavarsi immediatament ed abbondantement con prodotti idonei da indicarsi da part del fabbricant nl na aanrak met de huid onmiddellijk wassen met veel aan te geven door de fabrik pt apó contacto pele lavar imediata abundantement produto adequado indicar pelo produtor fi roiskeet iholta huuhdeltava välittömästi runsaalla määrällä aineen ilmoittaa valmistaja maahantuoja sv vid kontakt med huden tvätta genast med mycket ang av tillverkaren es tirar lo residuo por el desagü da må ikk tømme kloakafløb de nicht die kanalis gelangen lassen el en empti drain fr ne pa jeter le résidu égout gettar residui nell fognatur nl afval niet de gootsteen werpen pt não deitar os resíduo esgoto fi ei saa tyhjentää viemäriin sv töm ej avloppet es echar jamá agua est producto da hæld aldrig vand på eller produktet de niemal wasser hinzugießen el en add water product fr ne jamai verser de eau dan ce produit versar acqua sul prodotto nl nooit water op deze stof gieten pt nunca adicionar água est produto fi tuotteeseen ei saa lisätä vettä sv häll aldrig vatten på eller produkten es evítes la acumulación de carga electroestática da træf foranstaltning mod statisk elektricitet de maßnahmen gegen elektrostatisch aufladungen treffen el en precautionari measur static discharg fr éviter accumul de charg électrostatiqu evitar accumulo di carich elettrostatich nl maatregelen treffen tegen ontladingen van statisch elektriciteit pt evitar acumulação de carga electrostática fi estettävä staattisen sähkön aiheuttama kipinöinti sv vidtag åtgärder mot statisk elektricitet es elimínens lo residuo del producto su recipient con toda la precaucion posibl da materialet og det behold skal bortskaff på en sikker måde de abfäll und behälter müssen gesichert weis beseitigt werden el en materi contain dispos safe fr ne se débarrass de ce produit de son récipient qu en prenant tout le précaution usag disfarsi del prodotto del recipient se con le dovut precauzioni nl deze stof en de verpak op veilig wijz afvoeren pt não se desfaz dest produto seu recipient sem tomar precauçõ de segurança devida fi tämä ain ja sen pakkau hävitettävä turvallisesti sv produkt och förpackn skall oskadliggöra på säkert sätt es úsese indumentaria protectora adecuada da brug særligt arbejdstøj de bei der arbeit geeignet schutzkleidung tragen el en wear suitabl protect cloth fr porter vêtement de protect approprié usar indumenti protettivi adatti nl draag geschikt beschermend klede pt usar vestuário de protecção adequado fi käytettävä sopivaa suojavaatetusta sv använd lämpliga skyddskläder es úsens guant adecuado da brug egned beskyttelseshandsk arbejdet de geeignet schutzhandschuh tragen el en wear suitabl glove fr porter de gant approprié usar guanti adatti nl draag geschikt handschoenen pt usar luva adequada fi käytettävä sopivia suojakäsineitä sv använd lämpliga skyddshandskar es en caso de ventilación insuficient úsese equipo respiratorio adecuado da brug egnet åndedrætsværn hvi effektiv ventil ikk er mulig de bei unzureichend belüftung atemschutzgerät anlegen el en case insuffici ventil wear suitabl respiratori equip fr en ca de ventil insuffisant porter appareil respiratoir approprié caso di ventilazion insufficient usar apparecchio respiratorio adatto nl bij ontoereikend ventilati een geschikt adembescherm dragen pt em caso de ventilação insuficient usar equipamento respiratório adequado fi kemikaalin käyttö edellyttää tehokasta ilmanvaihtoa tai sopivaa hengityksensuojainta sv använd lämpligt andningsskydd vid otillräcklig ventil es úsese protección para lo ojo la cara da brug beskyttelsesbril ansigtsskærm arbejdet de schutzbril gesichtsschutz tragen el en wear ey face protect fr porter appareil de protect de yeux du visag proteggersi gli occhi la faccia nl een bescherm voor de ogen voor het gezicht dragen pt usar um equipamento protector para os olho face fi käytettävä silmien tai kasvonsuojainta sv använd skyddsglasögon eller ansiktsskydd es para limpiar el suelo lo objeto contaminado por est producto úsese especificar por el fabricant da gulvet og tilsmudsed genstand rens med midlern angiv af fabrikanten de fußboden und verunreinigt gegenständ mit reinigen materi vom herstel anzugeben el en clean floor object contamin materi manufactur fr pour nettoy le sol ou le objet souillé par ce produit utilis préciser par le fabric pulir il pavimento gli oggetti contaminati da questo prodotto usar da precisar da part del produttor nl voor de reinig van de vloer en all voorwerpen verontreinigd met dit materia gebruiken aan te geven door de fabrik pt para limpeza chão objecto contaminado por est produto utilizar especificar pelo produtor fi kemikaali puhdistettava pinnoilta käyttäen kemikaalin ilmoittaa valmistaja maahantuoja sv golv och förorenad föremål tvätta med ang av tillverkaren es en caso de incendio de explosión respir lo humo da undgå indånd røgen ved brand eller eksplos de explos und brandgas nicht einatmen el en case fire explos breath fume fr en ca incendi ou explos ne pa respir le fumé caso di incendio esplosion respirar fumi nl geval van brand en explosi inademen van rook vermijden pt em caso de incêndio ou explosão não respirar os fumo fi vältettävä palamisessa tai räjähdyksessä muodostuvan savun hengittämistä sv undvik inandn av rök vid brand eller explos es durant la fumigacion pulverizacion úsese equipo respiratorio adecuado denominación es adecuada especificar por el fabricant da brug egnet åndedrætsværn ved rygn sprøjtning den eller de pågældend betegnels angiv af fabrikanten de beim räuchern versprühen geeignet atemschutzgerät anlegen geeignet bezeichnung en vom herstel anzugeben el en fumig sprai wear suitabl respiratori equip word manufactur fr pendant le fumig pulvéris porter appareil respiratoir approprié term approprié indiqu par le fabric durant le fumigazioni polimerizzazioni usar apparecchio respiratorio adatto termin appropriato da precisar da part del produttor nl tijden de ontsmet bespuit een geschikt adembescherm dragen geschikt term en door de fabrik aan te geven pt durant fumigaçõ pulverizaçõ usar equipamento respiratório adequado termo adequado indicar pelo produtor fi kaasutuksen ruiskutuksen aikana käytettävä sopivaa hengityksensuojainta oikean sanamuodon valitse valmistaja maahantuoja sv använd lämpligt andningsskydd vid gasn sprutn specificera av tillverkaren es en caso de incendio utilizar lo medio de extinción lo debe especificar el fabricant si el agua aumenta el riesgo se deberá añadir quot usar nunca agua quot da brug ved brandslukn den nøjagtig type brandslukningsudstyr angiv af fabrikanten såfremt vand ikk må bruge tilføj quot brug ikk vand quot de zum löschen vom herstel anzugeben verwenden wenn wasser die gefahr erhöht anfügen quot kein wasser verwenden quot el quot quot en case fire space precis type fire fight equip water increas risk add quot water quot fr en ca incendi utilis moyen extinct préciser par le fabric si eau augment le risqu ajout quot ne jamai utilis eau quot caso di incendio usar mezzi estinguenti idonei da indicarsi da part del fabbricant se acqua aumenta il rischio precisar quot usar acqua quot nl geval van brand gebruiken blusmiddelen aan te duiden door de fabrik indien water het risico vergroot toevoegen quot nooit water gebruiken quot pt em caso de incêndio utilizar meio de extinção especificar pelo produtor se água aumentar os risco acrescentar quot nunca utilizar água quot fi sammutukseen käytettävä ilmoitettava sopiva sammutusmenetelmä jo vesi lisää vaaraa lisättävä sanat sammutukseen ei saa käyttää vettä sv vid brandsläckn använd ang lämplig metod om vatten ökar riskerna lägg till quot använd aldrig vatten quot es en caso de accident malestar acúdas inmediatament al médico si es posibl muéstresel la etiqueta da ved ulykkestilfæld eller ved ildebefindend er omgåend lægebehandl nødvendig vi etiketten hvi det er muligt de bei unfal oder unwohlsein sofort arzt zuziehen wenn möglich dies etikett vorzeigen el en case accid feel unwel seek medic advic immedi show label fr en ca accid ou de malais consult immédiat médecin si lui montrer étiquett caso di incident di malesser consultar immediatament il medico se possibil mostrargli etichetta nl bij een ongev indien men zich onwel voelt onmiddellijk een art raadplegen indien mogelijk hem dit etiket tonen pt em caso de acident ou de indisposição consultar imediatament médico se possível mostrar lhe rótulo fi onnettomuuden sattuessa tai tunnettaessa pahoinvointia hakeuduttava heti lääkärin hoitoon näytettävä tätä etikettiä mikäli mahdollista sv vid olycksfal illamåend eller annan påverkan kontakta omedelbart läkare visa om möjligt etiketten es en caso de ingestión acúdas inmediatament al médico muéstresel la etiqueta el envas da ved indtagels kontakt omgåend læge og vi denn behold eller etiket de bei verschlucken sofort ärztlichen rat einholen und verpackung oder etikett vorzeigen el en swallow seek medic advic immedi show contain label fr en ca ingest consult immédiat médecin lui montrer emballag ou étiquett caso ingestion consultar immediatament il medico mostrargli il contenitor etichetta nl geval van inslikken onmiddellijk een art raadplegen en verpak etiket tonen pt em caso de ingestão consultar imediatament médico mostrar lhe embalagem ou rótulo fi jo ainetta nielti hakeuduttava heti lääkärin hoitoon ja näytettävä tämä pakkau tai etiketti sv vid förtäring kontakta genast läkare och visa denna förpackn eller etiketten es consérves una temperatura superior especificar por el fabricant da må ikk opbevar ved temperatur på angiv af fabrikanten de nicht bei temperaturen über aufbewahren vom herstel anzugeben el en temperatur exceed manufactur fr conserv un températur ne dépassant pa préciser par le fabric conservar temperatura superior da precisar da part del fabbricant nl bewaren bij een temperatuur beneden aan te geven door de fabrik pt conservar uma temperatura não exceda especificar pelo produtor fi säilytettävä all lämpötilassa valmistaja maahantuoja ilmoittaa lämpötilan sv förvara vid en temperatur som int överstig ang av tillverkaren es consérves húmedo con medio apropiado especificar por el fabricant da hold befugtet med passend middel angiv af fabrikanten de feucht halten mit geeignet mittel vom herstel anzugeben el en wet materi manufactur fr maintenir humid avec moyen approprié préciser par le fabric mantener umido con mezzo appropriato da precisar da part del fabbricant nl inhoud vochtig houden met middel aan te geven door de fabrik pt manter húmido materi adequado especificar pelo produtor fi säilytettävä kosteana valmistaja maahantuoja ilmoittaa sopivan aineen sv innehållet skall hålla fuktigt med lämpligt materi ang av tillverkaren es consérves únicament en el recipient de origen da må kun opbevar den original emballag de nur im originalbehält aufbewahren el en origin contain fr conserv uniqu dan le récipient origin conservar soltanto nel recipient original nl uitsluitend de oorspronkelijk verpak bewaren pt conservar unicament recipient de origem fi säilytettävä vain alkuperäispakkauksessa sv förvara endast originalförpackningen es mezclar con especificar por el fabricant da må ikk bland med angiv af fabrikanten de nicht mischen mit vom herstel anzugeben el en mix manufactur fr ne pa mélanger avec spécifier par le fabric mescolar con da specificar da part del fabbricant nl niet vermengen met aan te geven door de fabrik pt não misturar especificar pelo produtor fi ei saa sekoittaa valmistaja maahantuoja ilmoittaa aineen kanssa sv blanda int med ang av tillverkaren es úsese únicament en lugar bien ventilado da må kun bruge på steder med god ventil de nur gut gelüfteten bereichen verwenden el en ventil area fr utilis seulement dan de zone bien ventilé usar soltanto luogo ben ventilato nl uitsluitend op go geventileerd plaatsen gebruiken pt utilizar soment em locai bem ventilado fi huolehdittava hyvästä ilmanvaihdosta sv sörj för god ventil es usar sobr grand superfici en local habitado da bør ikk anvend til større flader beboels eller opholdsrum de nicht großflächig für wohn und aufenthaltsräum zu verwenden el en recommend interior larg surfac area fr ne pa utilis sur de grand surfac dan le locaux habité utilizzar su grandi superfici locali abitati nl niet voor gebruik op grote oppervlakken woon en verblijfruimten pt não utilizar em grand superfíci no locai habitado fi ei suositella sisäkäyttöön laajoilla pinnoilla sv olämpligt för användn inomhu vid behandl av stora ytor es evítes la exposición recábens instruccion especial ant del uso da undgå enhver kontakt indhent særlige anvisning før brug de exposit vermeiden vor gebrauch besonder anweisungen einholen el en avoid exposur obtain special instruct fr éviter exposit se procur de instruct spécial avant utilis evitar esposizion procurarsi speciali istruzioni prima dell uso nl blootstel vermijden vóór gebruik special aanwijzingen raadplegen pt evitar exposição obter instruçõ específica ant da utilização fi vältettävä altistumista ohjeet luettava ennen käyttöä sv undvik expon begär specialinstruktion före användn es elimínens esta sustancia su recipient en punto de recogida pública de residuo especial peligroso da aflev dett material og det behold til indsamlingsst farligt affald og problemaffald de dies produkt und seinen behälter der problemabfallentsorgung zuführen el en dispos materi contain hazard special wast collect point fr élimin ce produit son récipient dan centr de collect de déchet dangereux ou spéciaux smaltir questo material relativi contenitori punto di raccolta rifiuti pericolosi speciali nl deze stof en de verpak naar inzamelpunt voor gevaarlijk bijzond afval brengen pt eliminar est produto seu recipient enviando os para local autorizado para recolha de resíduo perigoso ou especiai fi tämä ain ja sen pakkau toimitettava ongelmajätteen vastaanottopaikkaan sv lämna detta materi och dess behållar till insamlingsstäl för farligt avfal es utilíces envas de seguridad adecuado para evitar la contaminación del medio ambient da skal indeslutt forsvarligt undgå miljøforuren de zur vermeidung einer kontamin der umwelt geeigneten behälter verwenden el en contain avoid environment contamin fr utilis récipient approprié pour éviter tout contamin du milieu ambiant usar contenitori adeguati evitar inquinamento ambiental nl neem passend maatregelen om verspreid het milieu te voorkomen pt utilizar um recipient adequado para evitar contaminação ambient fi käytettävä sopivaa säilytystapaa ympäristön likaantumisen ehkäisemiseksi sv förvara på lämpligt sätt för att undvika miljöföroren es remitirs al fabricant proveedor para obten información sobr su recuperación reciclado da indhent oplysning om genvind genanvendels ho producenten leverandøren de informationen zur wiederverwendung wiederverwertung beim herstel lieferanten erfragen el en refer manufactur supplier inform recoveri recycl fr consult le fabric fournisseur pour de inform rel la récupérat au recyclag richieder informazioni al produttor fornitor il recupero riciclaggio nl raadpleeg fabrik leveranci voor informati terugwin recycl pt solicitar ao produtor fornecedor informaçõ relativa sua recuperação reciclagem fi hanki valmistajalta luovuttajalta tietoja uudelleenkäytöstä kierrätyksestä sv rådfråga tillverkar leverantör om återvin återanvändn es elimínens el producto su recipient como residuo peligroso da dett material og det behold skal bortskaff som farligt affald de dies produkt und sein behälter sind al gefährlich abfal zu entsorgen el en materi contain dispos hazard wast fr élimin le produit son récipient comm déchet dangereux questo material il suo contenitor devono esser smaltiti rifiuti pericolosi nl deze stof en de verpak al gevaarlijk afval afvoeren pt est produto seu recipient devem ser eliminado como resíduo perigoso fi tämä ain ja sen pakkau käsiteltävä ongelmajätteenä sv detta materi och dess behållar skall ta om hand som farligt avfal es evítes su liberación al medio ambient recábens instruccion específica de la ficha de dato de seguridad da undgå udledn til miljøet se særlig vejledn leverandørbrugsanvisn de freisetzung die umwelt vermeiden besonder anweisungen einholen sicherheitsdatenblatt zu rate ziehen el en avoid releas environ refer special instruct safeti data sheet fr éviter le rejet dan environn consult le instruct spécial la fich de donné de sécurité disperder nell ambient riferirsi all istruzioni speciali schede inform materia di sicurezza nl voorkom loze het milieu vraag om special instructi veiligheidskaart pt evitar libertação para ambient obter instruçõ específica ficha de segurança fi vältettävä päästämistä ympäristöön lue erityisohjeet käyttöturvallisuustiedot sv undvik utsläpp till miljön lä särskilda instruktion varuinformationsblad es en caso de ingestión provocar el vómito acúdas inmediatament al médico muéstresel la etiqueta el envas da ved indtagels undgå fremprovoker opkastn kontakt omgåend læge og vi denn behold eller etiket de bei verschlucken kein erbrechen herbeiführen sofort ärztlichen rat einholen und verpackung oder dies etikett vorzeigen el en swallow induc vomit seek medic advic immedi show contain label fr en ca ingest ne pa fair vomir consult immédiat médecin lui montrer emballag ou étiquett caso di ingestion provocar il vomito consultar immediatament il medico mostrargli il contenitor etichetta nl bij inslikken niet het braken opwekken direct een art raadplegen en de verpak het etiket tonen pt em caso de ingestão não provocar vómito consultar imediatament um médico mostrar lhe embalagem ou rótulo fi jo kemikaalia nielti ei saa oksennuttaa hakeuduttava välittömästi lääkärin hoitoon ja näytettävä tämä pakkau tai etiketti sv vid förtäring framkalla ej kräkning kontakta genast läkare och visa denna förpackn eller etiketten es en caso de accident por inhalación alejar la víctima de la zona contaminada mantenerla en reposo da ved ulykkestilfæld ved indånd bring tilskadekomn ud frisk luft og hold ro de bei unfal durch einatmen verunfallten die frisch luft bringen und ruhigstellen el en case accid inhal remov casualti fresh air rest fr en ca accid par inhal transport la victim hor de la zone contaminé la garder au repo caso di incident inalazion allontanar infortunato dalla zona contaminata mantenerlo riposo nl bij een ongev door inadem slachtoff de friss lucht brengen en laten rusten pt em caso de inalação acident remov vítima da zona contaminada mantê la em repouso fi jo ainetta onnettomuuden sattuessa hengitetti siirrä henkilö raittiiseen ilmaan ja pidä hänet levossa sv vid olycksfal inandn flytta den drabbad till frisk luft och låt vila es en caso de ingestión enjuágues la boca con agua solament si la persona está conscient da ved indtagels skyl munden med vand kun hvi personen er ved bevidsth de bei verschlucken mund mit wasser ausspülen nur wenn verunfallt bei bewusstsein ist el en swallow rins mouth water person consciou fr en ca ingest rincer la bouch avec de eau seulement si la personn est conscient caso di ingestion sciacquar la bocca con acqua solament se infortunato coscient nl bij inslikken mond met water spoelen alleen al de persoon bij bewustzijn pt em caso de ingestão lavar repetidament boca água apena se vítima estiv conscient fi jo ainetta nielti huuhtel suu vedellä vain jo henkilö tajuissaan sv vid förtäring skölj munnen med vatten endast om personen är vid medvetand combinación de frase kombin af sætninger kombin der sätze combin phrase combinaison de phrase combinazioni dell frasi combinati van zinnen combinação da frase yhdistetyt lausekkeet sammansatta fraser es consérves bajo llave manténgas fuera del alcanc de lo niño da opbevar lå og utilgængeligt børn de unter verschluss und für kinder unzugänglich aufbewahren el en lock reach children fr conserv sou clef hor de porté de enfant conservar sotto chiav fuori della portata dei bambini nl achter slot en buiten bereik van kinderen bewaren pt guardar fechado chave fora alcanc da criança fi säilytettävä lukitussa tilassa ja lasten ulottumattomissa sv förvara låst utrymm och oåtkomligt för barn es consérves el recipient bien cerrado en lugar fresco da emballagen opbevar tæt lukket på køligt sted de behälter dicht geschlossen halten und einem kühlen ort aufbewahren el en contain tightli close cool place fr conserv le récipient bien fermé dan endroit frai tener il recipient ben chiuso luogo fresco nl gesloten verpak op een koel plaat bewaren pt conservar em recipient bem fechado em lugar fresco fi säilytettävä tiiviisti suljettuna viileässä paikassa sv förpackningen förvara väl tillsluten och svalt es consérves en lugar fresco bien ventilado lejo de material incompat especificar por el fabricant da opbevar køligt godt ventileret og adskilt fra uforligelig stoffer angiv af fabrikanten de einem kühlen gut gelüfteten ort entfernt von aufbewahren die stoff mit denen kontakt vermieden werden muss sind vom herstel anzugeben el en cool ventil place incompat materi manufactur fr conserv dan endroit frai bien ventilé écart de matièr incompat indiqu par le fabric conservar luogo fresco ben ventilato lontano da materiali incompatibili da precisar da part del fabbricant nl bewaren op een koel go geventileerd plaat verwijderd van stoffen waarme contact vermeden dient te worden aan te geven door de fabrik pt conservar em lugar fresco bem ventilado ao abrigo de matéria incompatívei indicar pelo produtor fi säilytettävä erillään yhteensopimattomat aineet ilmoittaa valmistaja maahantuoja viileässä paikassa jossa hyvä ilmanvaihto sv förvara svalt på väl ventilerad plat åtskilt från oförenliga ämnen ang av tillverkaren es consérves únicament en el recipient de origen en lugar fresco bien ventilado lejo de material incompat especificar por el fabricant da må kun opbevar originalemballagen på køligt godt ventileret sted og adskilt fra uforligelig stoffer angiv af fabrikanten de nur im originalbehält einem kühlen gut gelüfteten ort entfernt von aufbewahren die stoff mit denen kontakt vermieden werden muss sind vom herstel anzugeben el en origin contain cool ventil place incompat materi manufactur fr conserv uniqu dan le récipient origin dan endroit frai bien ventilé écart de matièr incompat indiqu par le fabric conservar soltanto nel contenitor original luogo fresco ben ventilato lontano da materiali incompatibili da precisar da part del fabbricant nl uitsluitend de oorspronkelijk verpak bewaren op een koel go geventileerd plaat verwijderd van stoffen waarme contact vermeden dient te worden aan te geven door de fabrik pt conservar unicament recipient de origem em lugar fresco bem ventilado ao abrigo de matéria incompatívei indicar pelo produtor fi säilytettävä alkuperäispakkauksessa viileässä paikassa jossa hyvä ilmanvaihto erillään yhteensopimattomat aineet ilmoittaa valmistaja maahantuoja sv förvara endast originalförpackningen på sval väl ventilerad plat åtskilt från oförenliga ämnen ang av tillverkaren es consérves únicament en el recipient de origen en lugar fresco bien ventilado da må kun opbevar originalemballagen på køligt godt ventileret sted de nur im originalbehält einem kühlen gut gelüfteten ort aufbewahren el en origin contain cool ventil place fr conserv uniqu dan le récipient origin dan endroit frai bien ventilé conservar soltanto nel contenitor original luogo fresco ben ventilato nl uitsluitend de oorspronkelijk verpak bewaren op een koel go geventileerd plaat pt conservar unicament recipient de origem em lugar fresco bem ventilado fi säilytettävä alkuperäispakkauksessa viileässä paikassa jossa hyvä ilmanvaihto sv förvara endast originalförpackningen på sval väl ventilerad plat es consérves en lugar fresco lejo de material incompat especificar por el fabricant da opbevar køligt og adskilt fra uforligelig stoffer angiv af fabrikanten de einem kühlen von entfernten ort aufbewahren die stoff mit denen kontakt vermieden werden muss sind vom herstel anzugeben el en cool place incompat materi manufactur fr conserv dan endroit frai écart de matièr incompat indiqu par le fabric conservar luogo fresco lontano da materiali incompatibili da precisar da part del fabbricant nl bewaren op een koel plaat verwijderd van stoffen waarme contact vermeden dient te worden aan te geven door de fabrik pt conservar em lugar fresco ao abrigo de matéria incompatívei indicar pelo produtor fi säilytettävä viileässä erillään yhteensopimattomat aineet ilmoittaa valmistaja maahantuoja sv förvara svalt och åtskilt från oförenliga ämnen ang av tillverkaren es manténgas el recipient bien cerrado en lugar seco da emballagen skal hold tæt lukket og opbevar tørt de behälter trocken und dicht geschlossen halten el en contain tightli close dry fr conserv le récipient bien fermé abri de humidité conservar il recipient ben chiuso al riparo dall umidità nl droog houden en een go gesloten verpak bewaren pt conservar recipient bem fechado ao abrigo da humidad fi säilytettävä kuivana ja tiiviisti suljettuna sv förpackningen förvara väl tillsluten och torrt es manténgas el recipient bien cerrado en lugar bien ventilado da emballagen skal hold tæt lukket og opbevar på godt ventileret sted de behälter dicht geschlossen einem gut gelüfteten ort aufbewahren el en contain tightli close ventil place fr conserv le récipient bien fermé dan endroit bien ventilé tener il recipient ben chiuso luogo ben ventilato nl gesloten verpak op een go geventileerd plaat bewaren pt manter recipient bem fechado em local bem ventilado fi säilytettävä tiiviisti suljettuna paikassa jossa hyvä ilmanvaihto sv förpackningen förvara väl tillsluten på väl ventilerad plat es manténgas el recipient bien cerrado consérves una temperatura superior especificar por el fabricant da emballagen skal hold tæt lukket og opbevar ved temperatur på ikk angiv af fabrikanten de behälter dicht geschlossen und nicht bei temperaturen über aufbewahren vom herstel anzugeben el en contain tightli close temperatur exceed manufactur fr conserv le récipient bien fermé un températur ne dépassant pa préciser par le fabric tener il recipient ben chiuso temperatura superior da precisar da part del fabbricant nl gesloten verpak bewaren bij een temperatuur beneden aan te geven door de fabrik pt manter recipient bem fechado conservar uma temperatura não exceda especificar pelo produtor fi säilytettävä tiiviisti suljettuna ja all lämpötilassa valmistaja maahantuoja ilmoittaa lämpötilan sv förpackningen förvara väl tillsluten vid en temperatur som int överstig ang av tillverkaren es comer ni beber ni fumar durant su utilización da der må ikk spise drikk eller ryge brugen de bei der arbeit nicht essen trinken oder rauchen el en eat drink smoke fr ne pa manger ne pa boir ne pa fumer pendant utilis mangiar né bere né fumar durant impiego nl niet eten drinken roken tijden gebruik pt não comer beber ou fumar durant utilização fi syöminen juominen ja tupakointi kielletti kemikaalia käytettäessä sv ät int drick int eller rök int hanteringen es evítes el contacto con lo ojo la piel da undgå kontakt med huden og øjnene de berührung mit den augen und der haut vermeiden el en avoid contact skin ey fr éviter le contact avec la peau le yeux evitar il contatto con gli occhi con la pell nl aanrak met de ogen en de huid vermijden pt evitar contacto pele os olho fi varottava kemikaalin joutumista ihol ja silmiin sv undvik kontakt med huden och ögonen es despué del contacto con la piel quítes inmediatament toda la ropa manchada salpicada lávese inmediata abundantement con producto especificar por el fabricant da kommer stof på huden tage tilsmudset tøj strak af og der vask med store mængder angiv af fabrikanten de bei berührung mit der haut beschmutzt getränkt kleidung sofort ausziehen und haut sofort abwaschen mit viel vom herstel anzugeben el en contact skin immedi contamin cloth wash immedi plenti manufactur fr aprè contact avec la peau enlev immédiat tout vêtement souillé ou éclaboussé se laver immédiat abondam avec produit approprié indiqu par le fabric caso di contatto con la pell togliersi di dosso immediatament gli indumenti contaminati lavarsi immediatament abbondantement con prodotti idonei da indicarsi da part del fabbricant nl na contact met de huid all besmett klede onmiddellijk uittrekken en de huid onmiddellijk wassen met veel aan te geven door de fabrik pt em caso de contacto pele retirar imediatament toda roupa contaminada lavar imediata abundantement produto adequado indicar pelo produtor fi ihokosketuksen jälkeen saastunut vaatetu riisuttava välittömästi ja roiskeet huuhdeltava välittömästi runsaalla määrällä aineen ilmoittaa valmistaja maahantuoja sv vid kontakt med huden tag genast av alla nedstänkta kläder och tvätta genast med mycket ang av tillverkaren es tirar lo residuo por el desagü elimínens lo residuo del producto su recipient con toda la precaucion posibl da må ikk tømme kloakafløb materialet og det behold skal bortskaff på en sikker måde de nicht die kanalis gelangen lassen abfäll und behälter müssen gesichert weis beseitigt werden el en empti drain dispos materi contain safe fr ne pa jeter le résidu égout ne se débarrass de ce produit de son récipient qu en prenant tout le précaution usag gettar residui nell fognatur disfarsi del prodotto del recipient se con le dovut precauzioni nl afval niet de gootsteen werpen stof en verpak op veilig wijz afvoeren pt não deitar os resíduo esgoto não eliminar produto seu recipient sem tomar precauçõ de segurança devida fi ei saa tyhjentää viemäriin tämä ain ja sen pakkau hävitettävä turvallisesti sv töm ej avloppet oskadliggör produkt och förpackn på säkert sätt es tirar lo residuo por el desagü elimínes esta sustancia su recipient en punto de recogida pública de residuo especial peligroso da må ikk tømme kloakafløb aflev dett material og det behold til indsamlingsst farligt affald og problemaffald de nicht die kanalis gelangen lassen dies produkt und seinen behälter der problemabfallentsorgung zuführen el en empti drain dispos materi contain hazard special wast collect point fr ne pa jeter le résidu égout élimin ce produit son récipient dan centr de collect de déchet dangereux ou spéciaux gettar residui nell fognatur smaltir questo material relativi contenitori punto di raccolta rifiuti pericolosi speciali nl afval niet de gootsteen werpen deze stof en de verpak naar een inzamelpunt voor gevaarlijk bijzond afval brengen pt não deitar os resíduo esgoto eliminar est produto seu recipient enviando os para local autorizado para recolha de resíduo perigoso ou especiai fi ei saa tyhjentää viemäriin tämä ain ja sen pakkau toimitettava ongelmajätteen vastaanottopaikkaan sv töm ej avloppet lämna detta materi och dess behållar till insamlingsstäl för farligt avfal es úsens indumentaria guant de protección adecuado da brug særligt arbejdstøj og egned beskyttelseshandsk de bei der arbeit geeignet schutzhandschuh und schutzkleidung tragen el en wear suitabl protect cloth glove fr porter vêtement de protect de gant approprié usar indumenti protettivi guanti adatti nl draag geschikt handschoenen en beschermend klede pt usar vestuário de protecção luva adequada fi käytettävä sopivaa suojavaatetusta ja suojakäsineitä sv använd lämpliga skyddskläder och skyddshandskar es úsens indumentaria guant adecuado protección para lo ojo la cara da brug særligt arbejdstøj egned beskyttelseshandsk og briller ansigtsskærm de bei der arbeit geeignet schutzkleidung schutzhandschuh und schutzbril gesichtsschutz tragen el en wear suitabl protect cloth glove ey face protect fr porter vêtement de protect approprié de gant appareil de protect de yeux du visag usar indumenti protettivi guanti adatti proteggersi gli occhi la faccia nl draag geschikt beschermend klede handschoenen en een beschermingsmiddel voor de ogen het gezicht pt usar vestuário de protecção luva equipamento protector para os olho face adequado fi käytettävä sopivaa suojavaatetusta suojakäsineitä ja silmien tai kasvonsuojainta sv använd lämpliga skyddskläder skyddshandskar samt skyddsglasögon eller ansiktsskydd es úsens indumentaria adecuada protección para lo ojo la cara da brug særligt arbejdstøj og egned beskyttelsesbril ansigtsskærm de bei der arbeit geeignet schutzkleidung und schutzbril gesichtsschutz tragen el en wear suitabl protect cloth ey face protect fr porter vêtement de protect approprié appareil de protect de yeux du visag usar indumenti protettivi adatti proteggersi gli occhi la faccia nl draag geschikt beschermend klede en een beschermingsmiddel voor de ogen het gezicht pt usar vestuário de protecção equipamento protector para os olho face adequado fi käytettävä sopivaa suojavaatetusta ja silmien tai kasvonsuojainta sv använd lämpliga skyddskläder samt skyddsglasögon eller ansiktsskydd es úsens guant adecuado protección para lo ojo la cara da brug egned beskyttelseshandsk og briller ansigtsskærm arbejdet de bei der arbeit geeignet schutzhandschuh und schutzbril gesichtsschutz tragen el en wear suitabl glove ey face protect fr porter de gant approprié appareil de protect de yeux du visag usar guanti adatti proteggersi gli occhi la faccia nl draag geschikt handschoenen en een beschermingsmiddel voor de ogen het gezicht pt usar luva equipamento protector para os olho face adequado fi käytettävä sopivia suojakäsineitä ja silmien tai kasvonsuojainta sv använd lämpliga skyddshandskar samt skyddsglasögon eller ansiktsskydd es consérves únicament en el recipient de origen temperatura superior especificar por el fabricant da må kun opbevar originalemballagen ved en temperatur på ikk angiv af fabrikanten de nur im originalbehält bei einer temperatur von nicht über vom herstel anzugeben aufbewahren el en origin contain temperatur exceed manufactur fr conserv uniqu dan le récipient origin un températur ne dépassant pa préciser par le fabric conservar soltanto nel contenitor original temperatura superior da precisar da part del fabbricant nl uitsluitend de oorspronkelijk verpak bewaren bij een temperatuur beneden aan te geven door de fabrik pt conservar unicament recipient de origem temperatura não exceda especificar pelo produtor fi säilytettävä alkuperäispakkauksessa all lämpötilassa valmistaja maahantuoja ilmoittaa lämpötilan sv förvara endast originalförpackningen vid en temperatur som int överstig ang av tillverkaren annex en mutagen revers mutat test bacteria concern es version concern da version concern de version concern el version concern fr version concern version concern nl version concern pt version concern fi version concern sv version annex fr administr du témoin positif par un voie différent de cell utilisé pour la substanc essai est accept concern es version concern da version concern de version concern el version concern en version concern version concern nl version concern pt version concern fi version concern sv version annex en gt refer graphic gt concern es version concern da version concern de version concern el version concern fr version concern version concern nl version concern pt version concern fi version concern sv version annex subchron oral toxic test repeat dose dai oral toxic studi rodent method subchron oral toxic test method replic oecd tg introduct assess evalu toxic characterist chemic determin subchron oral toxic repeat dose carri initi inform toxic obtain acut repeat dose dai toxic test dai studi inform health hazard aris repeat exposur prolong period time cover post wean matur growth adulthood studi provid inform major toxic effect target organ possibl accumul provid estim observ advers effect level exposur select dose level chronic studi establish safeti criteria human exposur method place addit emphasi neurolog endpoint indic immunolog reproduct effect care clinic observ anim obtain inform stress studi identif chemic potenti neurotox immunolog reproduct organ effect warrant depth investig gener introduct part definit dose amount test substanc administ dose express weight mg weight test substanc unit weight test anim mg kg constant dietari concentr ppm dosag gener term compris dose frequenc durat dose noael abbrevi observ advers effect level highest dose level advers treatment relat find observ principl test method test substanc oral administ daili graduat dose group experiment anim dose level group period dai period administr anim observ close sign toxic anim die kill test necropsi conclus test surviv anim kill necropsi descript test method prepar anim healthi anim acclim laboratori condit dai subject previou experiment procedur test anim characteris speci strain sourc sex weight ag anim randomli assign control treatment group cage arrang effect due cage placement minimis anim assign uniqu identif number prepar dose test substanc administ gavag diet drink water method oral administr depend purpos studi physic chemic properti test materi test substanc dissolv suspend suitabl vehicl recommend aqueou solut suspens consid consider solut emuls oil corn oil solut vehicl vehicl water toxic characterist vehicl stabil test substanc condit administr determin test condit experiment anim prefer speci rat rodent speci mous commonli laboratori strain young healthi adult anim emploi femal nullipar pregnant dose begin wean case anim week commenc studi weight variat anim minim exce weight sex studi conduct preliminari long term chronic toxic studi anim strain sourc studi number sex anim femal male dose level interim kill plan number increas number anim schedul kill complet studi base previou knowledg chemic close analogu consider includ addit satellit group anim sex control top dose group observ treatment period revers persist toxic effect durat post treatment period fix appropri regard effect observ dose level dose level concurr control limit test conduct dose level base result repeat dose rang find studi account exist toxicolog toxicokinet data test substanc relat materi limit physic chemic natur biolog effect test substanc highest dose level chosen aim induc toxic death sever suffer descend sequenc dose level select view demonstr dosag relat respons observ advers effect level noael lowest dose level fold interv frequent optim set descend dose level addit fourth test group prefer larg interv factor dosag control group untreat group vehicl control group vehicl administ test substanc treatment test substanc anim control group handl ident manner test group vehicl control group receiv vehicl highest volum test substanc administ diet reduc dietari intak pair fed control group distinguish reduct due palat toxicolog alter test model consider characterist vehicl addit effect absorpt distribut metabol retent test substanc effect chemic properti test substanc alter toxic characterist effect food water consumpt nutrit statu anim limit test test dose level equival mg kg bodi weight dai procedur studi produc observ advers effect toxic expect base data structur relat substanc full studi dose level consid limit test appli human exposur higher dose level procedur administr dose anim dose test substanc daili dai week period dai dose regim dai week justifi test substanc administ gavag singl dose anim stomach tube suitabl intub cannula maximum volum liquid administ time depend size test anim volum exce ml bodi weight case aqueou solut ml bodi weight irrit corros substanc reveal exacerb effect higher concentr variabl test volum minimis adjust concentr ensur constant volum dose level substanc administ diet drink water import ensur quantiti test substanc involv interfer normal nutrit water balanc test substanc administ diet constant dietari concentr ppm constant dose level term anim bodi weight altern substanc administ gavag dose similar time dai adjust maintain constant dose level term anim bodi weight dai studi preliminari long term chronic toxic studi similar diet studi observ observ period dai anim satellit group schedul follow observ period treatment detect persist recoveri toxic effect gener clinic observ made dai prefer time dai take consider peak period anticip effect dose clinic condit anim record daili begin end dai anim inspect sign morbid mortal prior exposur subject comparison week detail clinic observ made anim observ made home cage prefer standard arena similar time occas carefulli record prefer score system explicitli defin test laboratori effort made ensur variat observ condit minim sign note includ limit skin fur ey mucou membran occurr secret excret autonom activ lacrim pilo erect pupil size unusu respiratori pattern gait postur respons handl presenc clonic tonic movement stereotyp excess groom repetit circl bizarr behaviour mutil walk backward record ophthalmolog examin ophthalmoscop equival suitabl equip made prior administr test substanc termin studi prefer anim high dose control group ey detect anim examin end exposur period case earlier week sensori reactiv stimuli type auditori visual propriocept stimuli assess grip strength motor activ assess conduct detail procedur respect refer altern procedur referenc function observ conduct end studi omit data function observ studi daili clinic observ reveal function deficit exception function observ omit group reveal sign toxic extent significantli interfer function test perform bodi weight food water consumpt anim weigh week measur food consumpt made weekli test substanc administ drink water water consumpt measur weekli water consumpt consid dietari gavag studi drink activ alter haematolog clinic biochemistri blood sampl name site store applic condit end test period sampl collect prior part procedur kill anim haematolog examin made end test period interim blood sampl collect haematocrit haemoglobin concentr erythrocyt count total differenti leukocyt count platelet count measur blood clot time potenti clinic biochemistri determin investig major toxic effect tissu specif effect kidnei liver perform blood sampl obtain anim prior part procedur kill anim found moribund intercurr kill similar manner haematolog investig interim sampl clinic biochem test perform overnight fast anim prior blood sampl recommend determin plasma serum includ sodium potassium glucos total cholesterol urea blood urea nitrogen creatinin total protein albumin enzym indic hepatocellular effect alanin aminotransferas aspart aminotransferas alkalin phosphatas gamma glutamyl transpeptidas sorbitol dehydrogenas measur addit enzym hepat origin bile acid provid inform circumst includ option urinalysi determin perform week studi time urin volum collect appear volum osmol specif graviti ph protein glucos blood blood cell addit studi investig serum marker gener tissu damag consid determin carri properti test substanc suspect affect relat metabol profil includ calcium phosphoru fast triglycerid specif hormon methaemoglobin cholinesteras identifi chemic class case case basi flexibl approach depend speci observ expect effect substanc histor baselin data inadequ consider haematolog clinic biochemistri variabl determin dose commenc gener recommend data gener treatment gross necropsi anim studi subject full detail gross necropsi includ care examin extern surfac bodi orific cranial thorac abdomin caviti content liver kidnei adren test epididymid uteru ovari thymu spleen brain heart anim found moribund intercurr kill trim adher tissu wet weight dissect avoid dry tissu preserv fixat medium type tissu intend subsequ histopatholog examin gross lesion brain repres region includ cerebrum cerebellum medulla pon spinal cord level cervic mid thorac lumbar pituitari thyroid parathyroid thymu oesophagu salivari gland stomach small larg intestin includ peyer patch liver pancrea kidnei adren spleen heart trachea lung preserv inflat fix immers aorta gonad uteru accessori sex organ femal mammari gland prostat urinari bladder gall bladder mous lymph node prefer lymph node cover rout administr distant rout administr cover system effect peripher nerv sciatic tibial prefer close proxim muscl section bone marrow fresh bone marrow aspir skin ey observ ophthalmolog examin clinic find suggest examin addit tissu organ consid target organ base properti test substanc preserv histopatholog full histopatholog carri preserv organ tissu anim control high dose group examin extend anim dosag group treatment relat observ high dose group gross lesion examin satellit group histopatholog perform tissu organ identifi show effect treat group data report data individu data provid addition data summaris tabular form show test group number anim start test number anim found dead test kill human reason time death human kill number show sign toxic descript sign toxic observ includ time onset durat sever toxic effect number anim show lesion type lesion percentag anim displai type lesion applic numer result evalu gener accept statist method statist method data analys select design studi test report test report includ inform test substanc physic natur puriti physico chemic properti identif data vehicl justif choic vehicl water test speci speci strain number ag sex anim sourc hous condit diet individu weight anim start test test condit rational dose level select detail test substanc formul diet prepar achiev concentr stabil homogen prepar detail administr test substanc actual dose mg kg bodi weight dai convers factor diet drink water test substanc concentr ppm actual dose applic detail food water qualiti result bodi weight bodi weight food consumpt water consumpt applic toxic respons data sex dose level includ sign toxic natur sever durat clinic observ revers result ophthalmolog examin sensori activ grip strength motor activ assess haematolog test relev base line valu clinic biochemistri test relev base line valu termin bodi weight organ weight organ bodi weight ratio necropsi find detail descript histopatholog find absorpt data statist treatment result discuss result conclus refer ipc principl method assess neurotox exposur chemic environment health criteria document tupper wallac util neurolog examin rat acta neurobiol exp pp gad neuromuscular screen industri toxicolog toxicol environ health pp moser mc daniel phillip rat strain stock comparison function observ batteri baselin valu effect amitraz toxicol appl pharmacol pp meyer tilson byrd rilei method routin assess fore hind limb grip strength rat mice neurobehav toxivol pp crofton howard moser gill reiter tilson macphail interlaboratori comparison motor activ experi implic neurotoxicolog assess neurotoxicol teratol pp weingand brown hall al quot harmonis anim clinic patholog test toxic safeti studi quot fundam amp appl toxicol pp number measur serum plasma notabl glucos overnight fast prefer major reason prefer increas variabl inevit result fast tend mask subtl effect make interpret difficult hand overnight fast interfer gener metabol anim feed studi disturb daili exposur test substanc overnight fast adopt clinic biochem determin perform conduct function observ studi annex subchron oral toxic test repeat dose dai oral toxic studi rodent method subchron oral toxic test method replic oecd tg introduct assess evalu toxic characterist chemic determin subchron oral toxic repeat dose carri initi inform toxic obtain acut repeat dose dai toxic test dai studi inform health hazard aris repeat exposur period rapid growth young adulthood studi provid inform major toxic effect target organ possibl accumul provid estim observ advers effect level exposur select dose level chronic studi establish safeti criteria human exposur test method identif rodent speci advers effect chemic exposur effect observ studi clarif characteris rodent speci toxicokinet studi specif rodent speci relev choic laboratori anim specif reason justifi rodent speci gener introduct part definit dose amount test substanc administ dose express weight mg weight test substanc unit weight test anim mg kg constant dietari concentr ppm dosag gener term compris dose frequenc durat dose noael abbrevi observ advers effect level highest dose level advers treatment relat find observ principl test method test substanc oral administ daili graduat dose group experiment anim dose level group period dai period administr anim observ close sign toxic anim die kill test necropsi conclus test surviv anim kill necropsi descript test method select anim speci commonli rodent speci dog defin breed beagl frequent speci swine mini pig primat recommend justifi young healthi anim emploi case dog dose begin prefer month month ag studi conduct preliminari long term chronic toxic studi speci breed studi prepar anim healthi young anim acclim laboratori condit subject previou experiment procedur durat acclimatis depend select test speci sourc dai dog purpos bred swine resid coloni week anim extern sourc recommend test anim characteris speci strain sourc sex weight ag anim randomli assign control treatment group cage arrang effect due cage placement minimis anim assign uniqu identif number prepar dose test substanc administ diet drink water gavag capsul method oral administr depend purpos studi physic chemic properti test materi test substanc dissolv suspend suitabl vehicl recommend aqueou solut suspens consid consider solut emuls oil corn oil solut vehicl vehicl water toxic characterist vehicl stabil test substanc condit administr determin procedur number sex anim anim femal male dose level interim kill plan number increas number anim schedul kill complet studi number anim termin studi adequ meaning evalu toxic effect base previou knowledg substanc close analogu consider includ addit satellit group anim sex control top dose group observ treatment period revers persist toxic effect durat post treatment period fix appropri regard effect observ dosag dose level concurr control limit test conduct dose level base result repeat dose rang find studi account exist toxicolog toxicokinet data test compound relat materi limit physic chemic natur biolog effect test substanc highest dose level chosen aim induc toxic death sever suffer descend sequenc dose level select view demonstr dosag relat respons observ advers effect level noael lowest dose level fourfold interv frequent optim set descend dose level addit fourth test group prefer larg interv factor dosag control group untreat group vehicl control group vehicl administ test substanc treatment test substanc anim control group handl ident manner test group vehicl control group receiv vehicl highest volum test substanc administ diet reduc dietari intak pair fed control group distinguish reduct due palat toxicolog alter test model consider characterist vehicl addit effect absorpt distribut metabol retent test substanc effect chemic properti test substanc alter toxic characterist effect food water consumpt nutrit statu anim limit test test dose level equival mg kg bodi weight dai procedur studi produc observ advers effect toxic expect base data structur relat substanc full studi dose level consid limit test appli human exposur higher dose level administr dose anim dose test substanc daili dai week period dai dose regim dai week justifi test substanc administ gavag singl dose anim stomach tube suitabl intub cannula maximum volum liquid administ time depend size test anim volum low irrit corros substanc reveal exacerb effect higher concentr variabl test volum minimis adjust concentr ensur constant volum dose level substanc administ diet drink water import ensur quantiti test substanc involv interfer normal nutrit water balanc test substanc administ diet constant dietari concentr ppm constant dose level term anim bodi weight altern substanc administ gavag capsul dose similar time dai adjust maintain constant dose level term anim bodi weight dai studi preliminari long term chronic toxic studi similar diet studi observ observ period dai anim satellit group schedul follow observ period treatment detect persist recoveri toxic effect gener clinic observ made dai prefer time dai take consider peak period anticip effect dose clinic condit anim record daili begin end dai anim inspect sign morbid mortal prior exposur subject comparison week detail clinic observ made anim observ made practic home cage standard arena prefer similar time occas effort made ensur variat observ condit minim sign toxic carefulli record includ time onset degre durat observ includ limit skin fur ey mucou membran occurr secret excret autonom activ lacrim pilo erect pupil size unusu respiratori pattern gait postur respons handl presenc clonic tonic movement stereotyp excess groom repetit circl bizarr behaviour record ophthalmolog examin ophthalmoscop equival suitabl equip made prior administr test substanc termin studi prefer anim high dose control group treatment relat ey detect anim examin bodi weight food water consumpt anim weigh week measur food consumpt made weekli test substanc administ drink water water consumpt measur weekli water consumpt consid dietari gavag studi drink activ alter haematolog clinic biochemistri blood sampl name site store applic condit end test period sampl collect prior part procedur kill anim haematolog includ haematocrit haemoglobin concentr erythrocyt count total differenti leukocyt count platelet count measur clot potenti clot time prothrombin time thromboplastin time investig start studi monthli interv midwai test period final end test period clinic biochemistri determin investig major toxic effect tissu specif effect kidnei liver perform blood sampl obtain anim start monthli interv midwai test final end test period test area consid electrolyt balanc carbohydr metabol liver kidnei function select specif test influenc observ mode action test substanc anim fast period speci prior blood sampl suggest determin includ calcium phosphoru chlorid sodium potassium fast glucos alanin aminotransferas aspart aminotransferas ornithin decarboxylas gamma glutamyl transpeptidas urea nitrogen albumin blood creatinin total bilirubin total serum protein measur urinalysi determin perform start midwai final end studi time urin volum collect urinalysi determin includ appear volum osmol specif graviti ph protein glucos blood blood cell addit paramet emploi extend investig observ effect addit studi investig marker gener tissu damag consid determin adequ toxicolog evalu includ analys lipid hormon acid base balanc methaemoglobin cholinesteras inhibit addit clinic biochemistri emploi extend investig observ effect identifi chemic class case case basi flexibl approach depend speci observ expect effect substanc gross necropsi anim studi subject full detail gross necropsi includ care examin extern surfac bodi orific cranial thorac abdomin caviti content liver gall bladder kidnei adren test epididymid ovari uteru thyroid parathyroid thymu spleen brain heart anim found moribund inter kill trim adher tissu wet weight dissect avoid dry tissu preserv fixat medium type tissu intend subsequ histopatholog examin gross lesion brain repres region includ cerebrum cerebellum medulla pon spinal cord level cervic mid thorac lumbar pituitari ey thyroid parathyroid thymu oesophagu salivari gland stomach small larg intestin includ peyer patch liver gall bladder pancrea kidnei adren spleen heart trachea lung aorta gonad uteru accessori sex organ femal mammari gland prostat urinari bladder lymph node prefer lymph node cover rout administr distant rout administr cover system effect peripher nerv sciatic tibial prefer close proxim muscl section bone marrow fresh bone marrow aspir skin clinic find suggest examin addit tissu organ consid target organ base properti test substanc preserv histopatholog full histopatholog carri preserv organ tissu anim control high dose group examin extend anim dosag group treatment relat observ high dose group gross lesion examin satellit group histopatholog perform tissu organ identifi show effect treat group data report data individu data provid addition data summaris tabular form show test group number anim start test number anim found dead test kill human reason time death human kill number show sign toxic descript sign toxic observ includ time onset durat sever toxic effect number anim show lesion type lesion percentag anim displai type lesion applic numer result evalu gener accept statist method statist method data analys select design studi test report test report includ inform test substanc physic natur puriti physico chemic properti identif data vehicl justif choic vehicl water test speci speci strain number ag sex anim sourc hous condit diet individu weight anim start test test condit rational dose level select detail test substanc formul diet prepar achiev concentr stabil homogen prepar detail administr test substanc actual dose mg kg bodi weight dai convers factor diet drink water test substanc concentr ppm actual dose applic detail food water qualiti result bodi weight bodi weight food consumpt water consumpt applic toxic respons data sex dose level includ sign toxic natur sever durat clinic observ revers ophthalmolog examin haematolog test relev base line valu clinic biochemistri test relev base line valu termin bodi weight organ weight organ bodi weight ratio necropsi find detail descript histopatholog find statist treatment result discuss result conclus annex fish juvenil growth test method growth toxic test method replic oecd tg introduct test design assess effect prolong exposur chemic growth juvenil fish base method develop ring test european union assess effect chemic growth juvenil rainbow trout oncorynchu mykiss flow condit document speci experi gain growth test zebrafish danio rerio ricefish medaka oryzia latip gener introduct part definit lowest observ effect concentr loec lowest test concentr test substanc substanc observ signific effect amp lt compar control test concentr loec harm effect equal greater observ loec observ effect concentr noec test concentr immedi loec ecx test method concentr test substanc variat growth rate fish compar control load rate wet weight fish volum water stock densiti number fish volum water individu fish specif growth rate express growth rate individu base initi weight tank averag specif growth rate express growth rate tank popul concentr pseudo specif growth rate express individu growth rate compar initi weight tank popul principl test method juvenil fish exponenti growth phase weight test chamber expos rang subleth concentr test substanc dissolv water prefer flow semi static static renew condit test durat dai fish fed daili food ration base initi fish weight recalcul dai end test fish weigh effect growth rate analys regress model order estim concentr variat growth rate ecx ec ec ec altern data compar control valu order determin lowest observ effect concentr loec observ effect concentr noec inform test substanc result acut toxic test test method prefer perform speci chosen test impli water solubl vapour pressur test substanc reliabl analyt method quantif substanc test solut report accuraci limit detect inform includ structur formula puriti substanc stabil water light pka pow result test readi biodegrad test method valid test test valid condit appli mortal control exce end test weight fish control increas permit detect minimum variat growth rate consid signific ring test shown rainbow trout weight fish control increas half initi weight dai initi weight fish final weight dai amp gt fish amp gt dissolv oxygen concentr air satur asv test water temperatur differ test chamber time test maintain rang temperatur rang test speci appendix descript test method apparatu normal laboratori equip oxygen ph meter equip determin water hard alkalin adequ apparatu temperatur control prefer continu monitor tank made chemic inert materi suitabl capac relat recommend load stock densiti section appendix suitabl accur balanc accur water water test speci show suitabl long term surviv growth test water constant qualiti period test ph water rang test rang ph unit hard mg caco recommend order ensur dilut water unduli influenc test result complexion test substanc sampl interv analysi measur heavi metal cu pb zn hg cd ni major anion cation ca mg na cl pesticid total organophosphoru total organochlorin pesticid total organ carbon suspend solid made month dilut water constant qualiti water qualiti demonstr constant year determin frequent interv extend month chemic characterist accept dilut water list appendix test solut test solut chosen concentr prepar dilut stock solut stock solut prefer prepar simpli mix agit test substanc diluit water mechan mean stir ultrason satur column solubl column achiev suitabl concentr stock solut solvent dispers solubilis agent requir case order produc suitabl concentr stock solut exampl suitabl solvent aceton ethanol methanol dimethylsulfoxid dimethylformamid triethyleneglycol exampl suitabl dispers cremophor rh tween methylcellulos hco care readili biodegrad agent aceton highli volatil compound problem bacteri built flow test solubilis agent signific effect fish growth visibl advers effect juvenil reveal solvent control flow test system continu dispens dilut stock solut test substanc meter pump proport dilut satur system requir deliv seri concentr test chamber flow rate stock solut dilut water check interv prefer daili test vari test ring test shown rainbow trout frequenc water remov test litr fish dai accept section semi static renew test frequenc medium renew depend stabil test substanc daili water renew recommend preliminari stabil test section test substanc concentr stabl rang nomin fall measur initi concentr renew period consider flow test select speci rainbow trout oncorhynchu mykiss recommend speci test experi gain ring test speci document speci test procedur adapt provid suitabl test condit experi zebrafish danio rerio ricefish medaka oryzia latip rational select speci experiment method report case hold fish test fish select popul singl stock prefer spawn held week prior test condit water qualiti illumin similar test fed minimum ration bodi weight dai prefer bodi weight dai hold period test hour set period mortal record criteria appli mortal greater popul dai reject entir batch mortal popul acclim addit dai mortal dai reject entir batch mortal popul dai accept batch fish receiv treatment diseas week preced test test test design quot test design quot relat select number space test concentr number tank concentr level number fish tank ideal test design chosen regard object studi method statist analysi avail cost experiment resourc statement object statist power size differ growth rate requir detect altern precis ecx prefer requir estim firm prescript size studi import recognis design optim make resourc method statist analysi necessarili optim recommend design estim loec noec recommend analysi regress case regress analysi prefer analysi varianc reason discuss stephan roger suitabl regress model found amp lt noec loec design analysi regress import consider design test analys regress effect concentr ec concentr rang effect test substanc interest necessarili span concentr includ test precis estim effect concentr made effect concentr middl rang concentr test preliminari rang find test help select test concentr enabl satisfactori statist model test includ control tank addit tank concentr solubilis agent control solubilis agent highest test concentr run addit test seri section geometr seri logarithm seri appendix logarithm space test concentr prefer tank addit tank provid replic distribut rang concentr order enabl closer space level measur equal desir design estim noec loec analysi varianc anova prefer replic tank concentr statist analysi tank level replic tank allow made variabl tank due individu fish experi shown tank variabl small compar tank fish variabl case examin accept altern perform statist analysi level individu fish convention test concentr geometr seri factor prefer exceed gener test perform replic tank number replic control tank number fish doubl number test concentr equal size opposit absenc replic tank number fish control group number test concentr anova base tank individu fish entail individu mark fish quot pseudo quot specif growth rate section replic tank enabl standard deviat quot tank concentr quot determin mean degre freedom error analysi varianc control replic danger error variabl bias increas growth rate question growth rate decreas increas concentr tend lead overestim variabl procedur select weigh test fish import minimis variat weight fish begin test suitabl size rang speci recommend test appendix batch fish test rang individu weight start test ideal arithmet weight case exce recommend weight subsampl fish test order estim weigh food withheld stock popul hour prior start test fish chosen random gener anaesthet aqueou solut mg tricain methan sulphon ms neutralis addit part sodium bicarbon part ms fish weight individu wet weight blot dry precis appendix fish weight intend rang retain randomli distribut test vessel total wet weight fish test vessel record anaesthet likewis handl fish includ blot weigh stress injuri juvenil fish speci small size handl juvenil fish utmost care avoid stress injur test anim fish weigh dai test section deem recalcul food ration fish weigh dai test section method photograph method determin fish size basi food ration adjust condit exposur durat test durat amp gt dai load rate stock densiti import load rate stock densiti test speci appendix stock densiti high overcrowd stress occur lead reduc growth rate possibl diseas low territori behaviour induc affect growth case load rate low order dissolv oxygen concentr asv maintain aerat ring test shown rainbow trout load rate trout litr volum accept recommend frequenc water remov test litr fish dai feed fish fed food appendix suffici rate induc accept growth rate care avoid microbi growth water turbid rainbow trout rate bodi weight dai satisfi condit daili ration divid equal portion fish feed dai separ hour ration base initi total fish weight test vessel fish weight dai ration recalcul food withheld fish hour prior weigh uneaten food fecal materi remov test vessel dai carefulli clean bottom tank suction light temperatur photoperiod water temperatur test speci appendix test concentr concentr test substanc requir test design section prior knowledg toxic test substanc acut test rang find studi select test concentr justif fewer concentr highest test concentr exce substanc solubl limit water solubilis agent assist stock solut prepar final concentr greater ml prefer test vessel section effort made avoid materi control number dilut water control depend test design section solubilis agent number solubilis agent control dilut water control includ frequenc analyt determin measur test concentr test substanc determin regular interv flow test flow rate diluent toxic stock solut check interv prefer daili vari test test substanc concentr expect nomin valu rang section recommend minimum highest lowest test concentr analys start test weekli interv test concentr test substanc expect remain nomin basi stabil data test substanc analys test concentr regim semi static renew test concentr test substanc expect remain nomin valu recommend minimum highest lowest test concentr analys freshli prepar immedi prior renew start studi weekli test concentr test substanc expect remain nomin test concentr analys regim stabl substanc recommend result base measur concentr evid demonstr concentr test substanc solut satisfactorili maintain nomin measur initi concentr test result base nomin measur valu sampl filter μm pore size centrifug centrifug recommend procedur test materi adsorb filter filtrat accept test dissolv oxygen ph temperatur measur test vessel total hard alkalin salin relev measur control vessel highest concentr minimum dissolv oxygen salin relev measur time begin middl end test semi static test recommend dissolv oxygen measur frequent prefer water renew week ph measur begin end water renew static renew test weekli flow test hard alkalin measur test temperatur prefer monitor continu test vessel observ weight end test surviv fish weigh wet weight blot dry group test vessel individu weigh anim test vessel prefer individu weight requir fish individu mark case measur individu weight determin individu fish specif growth rate mark techniqu select avoid stress anim altern freez mark colour fine fish line fish examin daili test period extern abnorm haemorrhag discolor abnorm behaviour note mortal record dead fish remov dead fish replac load rate stock densiti suffici avoid effect growth number fish tank feed rate adjust data report treatment result recommend statistician involv design analysi test test method consider variat experiment design number test chamber number test concentr number fish view option test design specif guidanc statist procedur growth rate calcul test vessel mortal exce mortal rate test concentr whichev method analys data central concept specif growth rate time time defin wai depend fish individu mark tank averag requir gt refer graphic gt gt refer graphic gt gt refer graphic gt individu fish specif growth rate tank averag specif growth rate quot pseudo quot specif growth rate weight fish time loge logarithm weight individu fish start studi period loge logarithm weight individu fish end studi period gt refer graphic gt averag logarithm valu fish tank start studi period gt refer graphic gt averag logarithm valu fish tank end studi period time dai start end studi period calcul dai period measur dai dai period analysi result regress concentr respons model method analysi fit suitabl mathemat relationship specif growth rate concentr enabl estim quot ecx quot requir ec method calcul individu fish analysi base tank averag method prefer case smallest speci tank averag specif growth rate plot graphic concentr order inspect concentr respons relationship express relationship concentr model chosen choic support reason number fish surviv tank unequ process model fit simpl linear weight unequ size group method fit model enabl estim ec dispers standard error confid interv deriv graph fit model shown relat data adequaci fit model analysi result estim loec test includ replic tank concentr level estim loec base analysi varianc anova tank averag specif growth rate section suitabl method dunnett william test compar averag concentr averag control identifi lowest concentr differ signific probabl level requir assumpt parametr method met normal distribut shapiro wilk test heterogen varianc bartlett test consider transform data homogenis varianc prior perform anova carri weight anova test includ replic tank concentr anova base tank insensit imposs situat accept compromis base anova quot pseudo quot specif growth rate individu fish averag test concentr compar averag control loec identifi recognis method allow protect variabl tank account variabl individu fish experi shown tank variabl small compar tank fish variabl individu fish includ analysi method outlier identif justif provid interpret result result interpret caution measur toxic concentr test solut occur level detect limit analyt method semi static test concentr test substanc decreas freshli prepar solut renew test report test report includ inform test substanc physic natur relev physic chemic properti chemic identif data includ puriti analyt method quantif test substanc test speci scientif possibl strain size supplier pre treatment test condit test procedur semi static renew flow load stock densiti test design number test vessel test concentr replic number fish vessel method prepar stock solut frequenc renew solubilis agent concentr nomin test concentr mean measur valu standard deviat test vessel method attain evid measur refer concentr test substanc true solut dilut water characterist ph hard alkalin temperatur dissolv oxygen concentr residu chlorin level measur total organ carbon suspend solid salin test medium measur measur made water qualiti test vessel ph hard temperatur dissolv oxygen concentr detail inform feed type food sourc amount frequenc result evid control met valid criterion surviv data mortal occur test concentr statist analyt techniqu statist base replic fish treatment data justif techniqu tabul data individu fish weight dai measur valu tank averag pseudo specif growth rate period dai possibl result statist analysi regress analysi anova prefer tabular graphic form loec noec ecx standard error incid unusu reaction fish visibl effect produc test substanc refer solb de lg environment effect chemic cfm sld report uk ring test method studi effect chemic growth rate fish wrc report prd meyer bierman orti phylogenet posit zebrafish danio rerio model system development biologi invit compar method proc soc lond pp ashlei mallett grandi eec ring test method determin effect chemic growth rate fish final report commiss european commun wrc report eec crossland method evalu effect toxic chemic fish growth chemospher pp nagel bresh casper hansen market munk scholz höfte effect dichloroanilin earli life stage zebrafish brachydanio rerio result compar laboratori studi ecotox environ safeti pp yamamoto tokio seri stock cultur biolog field medaka killifish biologi strain keigaku publish tokio japan holcomb benoit hammermeist leonard johnson acut long term effect chemic japanes medaka oryzia latip arch environ conta toxicol pp benoit holcomb spehar guidelin conduct earli life toxic test japanes medaka oryzia latip ecolog research seri epa environment protect agenc duluth minnesota stephan roger advantag regress analysi calcul result chronic toxic test aquat toxicolog hazard assess eighth symposium astm stp bahner hansen ed american societi test materi philadelphia pp environ canada biolog test method toxic test earli life stage salmonid fish rainbow trout coho salmon atlant salmon conserv protect ontario report ep rm pp cox plan experi wilei edt pack statist issu design test determin effect chemic growth rate fish room document oecd ad hoc meet expert aquat toxicolog wrc medmenham uk decemb dunnett multipl comparison procedur compar treatment control amer statist assoc pp dunnett tabl multipl comparison control biometr pp william test differ treatment mean dose level compar dose control biometr pp johnston atkinson glanvil techniqu sequenti feed colour food determin food intak individu rainbow trout oncorhynchu mykiss effect feed level aquacultur pp quinton blake effect feed cycl ration level compensatori growth respons rainbow trout oncorhynchu mykiss journal fish biologi pp post nutrit nutrit diseas fish chapter ix testbook fish health public neptun citi jersei usa pp bruce versteeg statist procedur model continu toxic data environ toxicol chem pp degraev coonei pollock reichenbach dean marcu mcintyr precis epa dai fathead minnow larval surviv growth test intra interlaboratori studi report ea american petroleum institut public electr power research institut palo alto ca norbert king interpol estim chronic toxic icp approach environment protect agenc environment research lab duluth minnesota tech rep nation effluent toxic asses center sept pp william comparison dose level dose control biometr pp appendix fish speci recommend test suitabl test condit gt tabl gt appendix chemic characterist accept dilut water gt tabl gt appendix logarithm seri concentr suitabl toxic test gt tabl gt fish short term toxic test embryo sac fry stage method short term toxic test method replic oecd tg introduct short term toxic test fish embryo sac fry stage short term test life stage newli fertilis egg end sac fry stage expos feed provid embryo sac fry test test termin sac fry nourish yolk sac test intend defin lethal limit extent subleth effect chemic specif stage speci test test provid inform form bridg lethal subleth test screen test full earli life stage test chronic toxic test test speci husbandri techniqu suffici advanc cover period chang endogen exogen feed born mind test incorpor stage life cycl fish gener liabl give accur estim chronic toxic chemic fish reduc exposur respect life stage reduc sensit underestim chronic toxic expect embryo sac fry test sensit full earli life stage test respect chemic high lipophil log pow amp gt chemic specif mode toxic action smaller differ sensit test expect chemic specif narcot mode action prior public test experi embryo sac fry test freshwat fish danio rerio hamilton buchanan teleostei cyprinida common zebrafish detail guidanc test perform speci appendix preclud speci experi tabl ia ib definit lowest observ effect concentr loec lowest test concentr test substanc substanc observ signific effect amp lt compar control test concentr loec harm effect equal greater observ loec observ effect concentr noec test concentr immedi loec principl test embryo sac fry stage fish expos rang concentr test substanc dissolv water protocol choic semi static flow procedur choic depend natur test substanc test begun place fertilis egg test chamber termin yolk sac larva test chamber complet absorb mortal starvat start control lethal lethal effect assess compar control valu determin lowest observ effect concentr observ effect concentr altern analys regress model order estim concentr percentag effect lc ecx defin effect inform test substanc result acut toxic test method prefer perform speci chosen test result select appropi rang test concentr earli life stage test water solubl includ solubl test water vapour pressur test substanc reliabl analyt method quantif substanc test solut report accuraci limit detect inform test substanc establish test condit includ structur formula puriti substanc stabil light stabil condit test pka pow result test readi biodegrad method valid test test valid condit appli surviv fertilis egg control relev solvent vessel greater equal limit defin appendic dissolv oxygen concentr air satur asv test water temperatur differ test chamber success dai time test temperatur rang test speci appendic descript test method test chamber glass chemic inert vessel dimens vessel larg complianc load rate section recommend test chamber randomli posit test area randomis block design treatment present block prefer complet randomis design systemat effect laboratori control block block account subsequ data analysi test chamber shield unwant disturb select fish speci recommend fish speci tabl preclud speci exampl tabl test procedur adapt provid suitabl test condit rational select speci experiment method report case hold brood fish detail hold brood stock satisfactori condit found oecd tg refer handl embryo larva embryo larva expos main vessel smaller vessel fit mesh side end permit flow test solut vessel turbul flow small vessel induc suspend arm arrang move vessel keep organ submerg siphon flush system fertilis egg salmonid fish support rack mesh apertur suffici larg larva drop hatch pasteur pipett remov embryo larva semi static test complet daili renew paragraph egg contain grid mesh hold egg main test vessel restraint remov larva hatch mesh retain prevent escap fish transfer larva expos air net releas fish egg contain caution fragil speci carp time transfer vari speci transfer semi static techniqu beaker shallow contain equip mesh screen slightli elev bottom beaker volum contain suffici compli load requir transfer embryo larva water water conform chemic characterist accept dilut water list appendix test speci show control surviv good appendic suitabl test water constant qualiti period test ph remain rang ph unit order ensur dilut water unduli influenc test result complex test substanc advers affect perform brood stock sampl interv analysi measur heavi metal cu pb zn hg cd ni major anion cation ca mg na cl pesticid total organophosphoru total organochlorin pesticid total organ carbon suspend solid made month dilut water constant qualiti water qualiti demonstr constant year determin frequent interv extend month test solut test solut chosen concentr prepar dilut stock solut stock solut prefer prepar simpli mix agit test substanc dilut water mechan mean stir ultrason satur colum solubl column achiev suitabl concentr stock solut solvent dispers solubilis agent avoid coupound requir case order produc suitabl concentr stock solut exampl suitabl solvent aceton ethanol methanol dimethylformamid triethyleneglycol exampl suitabl dispers cremophor rh tween methylcellulos hco care readili biodegrad agent aceton highli volatil problem bacteri built flow test solubilis agent signific effect surviv visibl advers effect earli life stage reveal solvent control effort made avoid materi semi static techniqu renew procedur test solut prepar clean vessel surviv egg larva gentli transfer vessel small volum solut avoid exposur air ii test organ retain vessel whilst proport quarter test water chang frequenc medium renew depend stabil test substanc daili water renew recommend preliminari stabil test section test substanc concentr stabl rang nomin fall measur initi concentr renew period consider flow test case care avoid stress larva water renew oper flow test system continu dispens dilut stock solut test substanc meter pump proport dilut satur system requir deliv seri concentr test chamber flow rate stock solut dilut water check interv prefer daili vari test flow rate equival test chamber volum hour found suitabl procedur inform perform fish embryo sac fry toxic test literatur exampl includ literatur section text condit exposur durat test start prefer minut egg fertilis embryo immers test solut commenc blastodisc cleavag stage case onset gastrula stage egg obtain commerci supplier start test immedi fertilis sensit test influenc delai start test test initi hour fertilis larva fed exposur period test termin yolk sac larva test chamber complet absorb mortal starvat start control durat depend speci recommend durat appendic load number fertilis egg start test suffici meet statist requir randomli distribut treatment fertilis egg divid equal equal difficult obtain equal batch speci replic test chamber concentr load rate biomass volum test solut low order dissolv oxygen concentr asv maintain aerat flow test load rate exceed hour exceed solut time bean recommend light temperatur photoperiod test water temperatur test speci appendic purpos temperatur monitor addit test vessel test concentr concentr test substanc space constant factor exceed requir curv relat lc period exposur acut studi consid select rang test concentr fewer concentr limit test narrow concentr interv circumst justif provid fewer concentr concentr substanc higher hour lc mg whichev lower test substanc test solubl limit test water solubilis agent aid prepar test solut section final concentr test vessel greater ml test vessel control dilut water control replic relev control solubilis agent replic run addit test seri frequenc analyt determin measur test concentr test substanc determin regular interv semi static test concentr test substanc expect remain nomin rang section recommend minimum highest lowest test concentr analys freshli prepar immedi prior renew occas space evenli test analys made sampl solut freshli prepar renew test concentr test substanc expect remain nomin basi stabil data substanc analys test concentr freshli prepar renew regim occas space evenli test determin test substanc concentr prior renew perform replic vessel test concentr determin made dai recommend result base measur concentr evid demonstr concentr test substanc solut satisfactorili maintain nomin measur initi concentr test result base nomin measur initi valu flow test similar sampl regim semi static test measur quot quot solut applic case test durat dai advis increas number sampl occas week set measur ensur test concentr remain stabl sampl centrifug filter ìm pore size centrifug filtrat appear separ bioavail fraction test substanc bioavail sampl subject treatment test dissolv oxygen ph temperatur measur test vessel total hard salin relev measur control vessel highest concentr minimum dissolv oxygen salin relev measur time begin middl end test semi static test recommend dissolv oxygen measur frequent prefer water renew week ôhe ph measur begin end water renew semi static test weekli flow test hard measur test temperatur measur daili prefer monitor continu test vessel observ stage embryon develop embryon stage gastrula stage begin exposur test substanc verifi precis repres sampl egg suitabl preserv clear literatur consult descript illustr embryon stage hatch surviv observ hatch surviv made daili number record desir make frequent observ begin test minut hour case surviv time relev number death acut toxic effect dead embryo larva remov observ decompos rapidli extrem care remov dead individu knock physic damag adjac egg larva extrem delic sensit criteria death vari life stage egg earli stage mark loss transluc chang colour caus coagul precipit protein lead white opaqu appear embryo absenc bodi movement absenc heartbeat opaqu discolor speci embryo transluc larva immobl absenc respiratori movement absenc heartbeat white opaqu colour central nervou system lack reaction mechan stimulu abnorm appear number larva show abnorm bodi form pigment stage yolk sac absorpt record adequ interv depend durat test natur abnorm note abnorm embryo larva occur natur order cent control speci abnorm anim remov test vessel death abnorm behaviour abnorm hyperventil uncoordin swim atyp quiescenc record adequ interv depend durat test effect difficult quantifi observ aid interpret mortal data provid inform mode toxic action substanc length end test measur individu length recommend standard fork total length caudal fin rot fin eros occur standard length gener run test coeffici variat length replic control amp lt weight end test individu weight measur dry weight hour prefer wet weight blot dry gener run test coeffici variat weight replic control amp lt observ result data statist analysi cumul mortal number healthi larva end test time start hatch end hatch hatch replic number larva hatch dai length weight surviv anim end test number larva deform abnorm appear number larva exhibit abnorm behaviour data report treatment result recommend statistician involv design analysi test method consider variat experiment design number test chamber number test concentr start number fertilis egg paramet measur view option test design specif guidanc statist procedur loec noec estim variat analys set replic analysi varianc anova conting tabl procedur order make multipl comparison result individu concentr control dunnett method found exampl size effect detect anova procedur power test calcul report note observ list section suitabl statist analysi anova cumul mortal number healthi larva end test analys probit method lc ecx estim suitabl curv logist curv fit data interest statist method squar linear squar curv parameteris lc ecx interest standard error estim directli greatli eas calcul confid limit lc ecx good reason prefer confid level side confid quot fit procedur prefer provid mean assess signific lack fit graphic method fit curv regress analysi suitabl observ list section interpret result result interpret caution measur toxic concentr test solut occur level detect limit analyt method interpret result concentr water solubl substanc made care test report test report includ inform test substanc physic natur relev physic chemic properti chemic identif data includ puriti analyt method quantif test substanc test speci scientif strain number parent fish femal provid requir number egg test sourc method collect fertilis egg subsequ handl test condit test procedur semi static flow time period fertilis start test load photoperiod test design number test chamber replic number embryo replic method prepar stock solut frequenc renew solubilis agent concentr nomin test concentr measur valu mean standard deviat test vessel method attain test substanc solubl water concentr test evid provid measur refer concentr test substanc solut dilut water characterist ph hard temperatur dissolv oxygen concentr residu chlorin level measur total organ carbon suspend solid salin test medium measur measur made water qualiti test vessel ph hard temperatur dissolv oxygen concentr result result preliminari studi stabil test substanc evid control met surviv accept standard test speci appendic data mortal surviv embryo larval stage mortal surviv dai hatch number hatch data length weight incid descript morpholog abnorm incid descript behaviour effect statist analysi treatment data test analys anova lowest observ effect concentr loec observ effect concentr noec respons assess includ descript statist procedur indic size effect detect test analys regress techniqu lc ecx confid interv graph fit model calcul explan deviat test method refer kristensen evalu sensit short term fish earli life stage test relat fel test method final report commiss european commun pp june astm standard guid conduct earli life stage toxic test fish american societi test materi pp brauhn schoettger acquisit cultur research fish rainbow trout fathead minnow channel catfish bluegil ecolog research seri epa duluth minnesota brung jone temperatur criteria freshwat fish protocol procedur ecolog research seri epa duluth minnesota laal biologi zebrafish brachydanio rerio fisheri research literatur review biol pp legault techniqu control time daili spawn collect egg zebrafish brachydanio rerio hamilton buchanan copeia pp dave damgaard grand martelin rosand viktor ring test embryo larval toxic test zebrafish brachydanio rerio chromium zinc toxic environment toxicolog chemistri pp birg black westerman short term fish amphibian embryo larval test determin effect toxic stress earli life stage estim chronic valu singl compound complex effluent environment toxicolog chemistri pp van leeuwen espeldoorn mol aquat toxicolog aspect dithiocarbam relat compound iii embryolarv studi rainbow trout salmo gairdneri aquat toxicolog pp kirchen west teleostean develop carolina tip carolina biolog suppli compani kirchen west japanes medaka care develop carolina biolog suppli compani north carolina pp dunnett multipl comparison procedur compar treatment control amer statist assoc pp dunnett tabl multipl comparison control biometr pp mc clave sullivan pearson statist analysi fish chronic toxic test data proceed aquat toxicolog symposium astm philadelphia van leeuwen adema herm quantit structur activ relationship fish earli life stage toxic aquat toxicolog pp environ canada toxic test earli life stage salmonid fish rainbow trout coho salmon atlant salmon biolog test method seri report ep rm decemb pp dave xiu toxic mercuri nickel lead cobalt embryo larva zebrafish brachydanio rerio arch environment contamin toxicolog pp meyer bierman orti phylogenet posit zebrafish danio rerio model system development biologi invit comper method proc royal societi london seri pp ghillebaert chaillou deschamp roubaud toxic effect ph level refer molecul common carp embryo ecotoxicolog environment safeti pp epa guidelin cultur japanes medaka oryzia latip epa report epa dec epa duluth epa guidelin conduct earli life stage toxic test japanes medaka oryzia latip epa report epa dec epa duluth de graev coonei mcintyr poccoc reichenbach dean marcu valid perform dai fathead minnow pimephal promela larval surviv growth test intra interlaboratori studi environ tox chem pp calow handbook ecotoxicolog blackwel oxford vol chapter method spawn cultur conduct toxic test earli life stage estuarin marin fish balon earli life histori fish development ecolog evolutionari perspect junk publ dordrecht pp blaxter pattern varieti develop hoar randal ed fish physiolog vol xia academ press pp tabl fish speci recommend test gt tabl gt tabl exampl document speci gt tabl gt appendix guidanc perform toxic test embryo sac fry zebrafish brachydanio rerio introduct zebrafish origin coromandel coast india inhabit fast flow stream common aquarium fish carp famili inform procedur care cultur found standard refer book tropic fish biologi fisheri research review laal fish rare exce mm length bodi cylindr dark blue horizont silveri stripe stripe run caudal anal fin back oliv green male slimmer femal femal silveri abdomen distend prior spawn adult fish toler larg fluctuat temperatur ph hard order healthi fish produc egg good qualiti optim condit provid spawn male pursu butt femal egg expel fertilis egg transpar adhes fall bottom eaten parent spawn influenc light morn light adequ fish spawn earli hour daybreak femal produc batch hundr egg weekli interv condit parent fish reproduct earli life stage select suitabl number healthi fish suitabl water appendix week prior intend spawn group fish allow breed produc batch egg test densiti fish period exce gram fish litr regular water purif system enabl densiti higher temperatur hold tank maintain fish provid vari diet consist commerci dry food live newli hatch arthemia chironomid daphnia white worm enchytraeid procedur outlin practic led suffici batch healthi fertilis egg test run femal male tank litr dilut water shield direct light left undisturb hour spawn trai bottom aquarium afternoon dai start test spawn trai consist frame plexi glass suitabl materi cm high mm coars net attach top μm fine net bottom number quot spawn tree quot consist untwist nylon rope attach coars net frame fish left dark hour faint light turn initi spawn hour spawn spawn trai remov egg collect spawn trai prevent fish eat egg time permit easi collect egg group fish spawn spawn egg test ii male femal fish hous individu week prior intend spawn dai abdomen femal distend genit papilla visibl male fish lack papilla spawn perform spawn tank equip fals mesh bottom tank fill dilut water depth water mesh cm femal male tank dai intend spawn water temperatur gradual increas degre higher acclimatis temperatur light turn tank left undisturb morn faint light turn initi spawn hour fish remov egg collect larger batch egg need obtain femal suffici number spawn tank set parallel record reproduct success individu femal prior test size batch qualiti femal highest reproduct success select breed egg transfer test vessel mean glass tube diamet mm provid flexibl suction bulb amount water accompani egg transfer small egg heavier water sink tube care prevent egg larva come contact air microscop examin sampl batch es carri ensur irregular development stage disinfect egg allow mortal rate egg highest hour fertilis mortal period egg degener result unsuccess fertilis develop failur qualiti batch egg depend femal fish femal consist produc good qualiti egg develop rate rate hatch vari batch successfulli fertilis egg yolk sac larva surviv egg hatch dai fertil yolk sac absorb approxim dai fertilis embryon develop defin hisaoka battl due transpar egg post hatch larva develop fish presenc malform observ approxim hour spawn fertilis egg distinguish fertilis examin egg larva test vessel small volum studi microscop test condit appli earli life stage list appendix optim valu ph valu hard dilut water mg caco calcul statist stage approach propos data mortal abnorm develop hatch time analys statist concentr advers effect paramet detect bodi length statist evalu approach advis toxic select kill smaller fish delai hatch time induc gross malform lead bias length measur roughli number fish measur treatment ensur valid test statist lc ec determin percentag surviv egg larva calcul correct mortal control accord abbott formula gt refer graphic gt correct surviv surviv observ test concentr surviv control lc determin suitabl method end test inclus morpholog abnorm ec statist desir guidanc found stephan estim loec noec object egg sac fry test compar concentr control determin loec multipl comparison procedur utilis refer laal biologi zebrafish brachydanio rerio fisheri research literatur review fish biol pp hisaoka battl normal develop stage zebrafish brachydanio rerio hamilton buchanan morph pp nagel untersuchungen zur eiprodukt beim zebrabärbl brachydanio rerio hamilton buchanan journal appli ichthyolog pp finnei probit analysi ed cambridg univers press great britain pp stephan increas us acut toxic test aquat toxicolog hazard assess confer astm stp pearson foster bishop ed american societi test materi pp dunnett multipl comparison procedur compar treatment control amer statist assoc pp dunnett tabl multipl comparison control biometr pp william test differ treatment mean dose level compar dose control biometr pp william comparison dose level dose control biometr pp sokal rohlf biometri principl practic statist biolog research freeman san francisco appendix test condit durat surviv criteria recommend speci gt tabl gt appendix test condit durat surviv criteria document speci gt tabl gt appendix chemic characterist accept dilut water gt tabl gt honeybe acut oral toxic test method acut toxic test method replic oecd tg introduct toxic test laboratori method design assess oral acut toxic plant protect product chemic adult worker honeybe assess evalu toxic characterist substanc determin acut oral toxic honeybe requir exposur bee chemic acut oral toxic test carri determin inher toxic pesticid chemic bee result test defin evalu method step wise programm evalu hazard pesticid bee base sequenti progress laboratori toxic test semi field field experi pesticid test activ substanc formul product toxic standard verifi sensit bee precis test procedur definit acut oral toxic advers effect occur maximum period hour oral administr singl dose test substanc dose amount test substanc consum dose express mass μg test substanc test anim μg bee real dose bee calcul bee fed collect averag dose estim total consum test substanc number test bee cage ld median lethal dose oral statist deriv singl dose substanc death anim administ oral rout ld express μg test substanc bee pesticid test substanc activ substanc formul product activ substanc mortal anim record dead complet immobil principl test method adult worker honeybe api mellifera expos rang dose test substanc dispers sucros solut bee fed diet free test substanc mortal record daili compar control valu mortal rate increas whilst control mortal remain accept level amp lt extend durat test maximum result analys order calcul ld case studi prolong valid test test valid condit appli averag mortal total number control exce end test ld toxic standard meet rang descript test method collect bee young adult worker bee race bee ag feed statu bee obtain adequ fed healthi diseas free queen coloni histori physiolog statu collect morn even test test condit dai bee collect frame brood suitabl collect earli spring late autumn avoid bee chang physiolog time test conduc earli spring late autumn bee emerg incub rear week quot bee bread quot pollen collect comb sucros solut bee treat chemic substanc antibiot anti varroa product toxic test week time end treatment hous feed condit easi clean ventil cage materi stainless steel wire mesh plastic dispos wooden cage group bee cage prefer size test cage number bee provid adequ space bee held dark experiment room temperatur rel humid record test handl procedur includ treatment observ conduct dai light sucros solut water final concentr food test dose food provid ad libitum feed system record food intak cage section glass tube approxim mm long mm wide open end narrow mm diamet prepar bee collect bee randomli alloc test cage randomli experiment room bee starv initi test recommend bee depriv food prior treatment bee equal term gut content start test moribund bee reject replac healthi bee start test prepar dose test substanc water miscibl compound dispers directli sucros solut technic product substanc low water solubl vehicl organ solvent emulsifi dispers low toxic bee aceton dimethylformamid dimethylsulfoxid concentr vehicl depend solubl test substanc concentr test concentr vehicl gener exceed control solut prepar solvent dispers solubilis test substanc separ control group solut water sucros solut solvent carrier concentr dose solut procedur test control group number dose replic test meet statist requir determin ld confid limit dose geometr seri factor exceed cover rang ld requir test dilut factor number concentr dosag determin relat slope toxic curv dose versu mortal consider statist method chosen analysi result rang find test enabl choic concentr dosag minimum replic test group bee dose test concentr minimum control batch bee run addit test seri control batch includ solvent carrier section toxic standard toxic standard includ test seri dose select cover expect ld minimum replic cage ten bee test dose prefer toxic standard dimetho report oral ld rang ìg bee toxic standard accept suffici data provid verifi expect dose respons parathion exposur administr dose test group bee provid ìl sucros solut water test substanc concentr larger volum requir product low solubl low toxic low concentr formul higher proport sucros solut amount treat diet consum group monitor consum feeder remov cage replac sucros solut sucros solut provid ad libitum compound higher concentr reject test dose result food consum maximum unconsum treat diet replac sucros solut amount treat diet consum assess measur volum weight treat diet remain durat durat test prefer test solut replac sucros solut mortal continu rise test durat extend maximum provid control mortal exce observ mortal record start test give dose prolong observ period requir assess made interv maximum provid control mortal exce amount diet consum group estim comparison rate consumpt treat untreat diet provid inform palat treat diet abnorm behaviour effect observ test period record limit test case test substanc expect low toxic limit test perform ìg bee order demonstr ld greater procedur includ replic test group test dose relev control assess amount treat diet comsum toxic standard mortal occur full studi conduct subleth effect observ section record data report data data summaris tabular form show treatment group control toxic standard group number bee mortal observ time number bee advers behaviour analys mortal data statist method probit analysi move averag binomi probabl plot dose respons curv recommend observ time calcul slope curv median lethal dose ld confid limit correct control mortal made abbott correct treat diet complet consum dose test substanc consum group determin ld express ìg test substanc bee test report test report includ inform test substanc physic natur relev physic chemic properti stabil water vapour pressur chemic identif data includ structur formula puriti pesticid ident concentr activ substanc test speci scientif race approxim ag week collect method date collect inform coloni collect test bee includ health adult diseas pre treatment test condit temperatur rel humid experiment room hous condit includ type size materi cage method prepar stock test solut solvent concentr method prepar stock solut frequenc renew solubilis agent concentr test design number test concentr number control test concentr control number replic cage number bee cage date test result result preliminari rang find studi perform raw data mortal dose test observ time graph dose respons curv end test ld valu confid limit recommend observ time test substanc toxic standard statist procedur determin ld mortal control biolog effect observ measur abnorm behaviour bee includ reject test dose rate consumpt diet treat untreat group deviat test procedur relev inform refer eppo council europ decis make scheme environment risk assess plant protect product honeybe eppo bulletin vol pp march gough mcindo lewi dimetho refer compound laboratori acut toxic test honeybe api mellifera journal apicultur research pp litchfield wilcoxon simplifi method evalu dose effect experi jour pharmacol exper ther pp finnei probit analysi ed cambridg london york abbott method comput effect insecticid jour econ entomol pp honeybe acut contact toxic test method acut toxic test method replic oecd tg introduct toxic test laboratori method design assess acut contact toxic plant protect product chemic adult worker honeybe assess evalu toxic characterist substanc determin acut contact toxic honeybe requir exposur bee chemic acut contact toxic test carri determin inher toxic pesticid chemic bee result test defin evalu method step wise programm evalu hazard pesticid bee base sequenti progress laboratori toxic test semi field field experi pesticid test activ substanc formul product toxic standard verifi sensit bee precis test procedur definit acut oral toxic advers effect occur maximum period hour topic applic singl dose substanc dose amount test substanc appli dose express mass ìg test substanc test anim ìg bee ld median lethal dose contact statist deriv singl dose substanc death anim administ contact ld ìg test substanc bee pesticid test substanc activ substanc formul product activ substanc mortal anim record dead complet immobil principl test method adult worker honeybe api mellifera expos rang dose test substanc dissolv carrier direct applic thorax droplet test durat mortal rate increas whilst control mortal remain accept level amp lt extend durat test maximum mortal record daili compar control valu result analys order calcul ld case studi prolong valid test test valid condit appli averag mortal total number control exce end test ld toxic standard meet rang descript test method collect bee young adult worker bee bee ag feed statu race bee obtain adequ fed healthi diseas free queen coloni histori physiolog statu collect morn even test test condit dai bee collect frame brood suitabl collect earli spring late autumn avoid bee chang physiolog time test conduc earli spring late autumn bee emerg incub rear week quot bee bread quot pollen collect comb sucros solut bee treat chemic substanc antibiot anti varroa product toxic test week time end treatment hous feed condit easi clean ventil cage materi stainless steel wire mesh plastic dispos wooden cage size test cage number bee provid adequ space group ten bee cage prefer bee held dark experiment room temperatur rel humid record test handl procedur includ treatment observ conduct dai light sucros solut water final concentr food provid ad libitum test time bee feeder glass tube approxim mm long mm wide open end narrow mm diamet prepar bee collect bee anaesthetis carbon dioxid nitrogen applic test substanc amount anaesthet time exposur minimis moribund bee reject replac healthi bee start test prepar dose test substanc appli solut carrier organ solvent water solut wet agent organ solvent aceton prefer organ solvent low toxic bee dimethylformamid dimethylsulfoxid water dispers formul product highli polar organ substanc solubl organ carrier solvent solut easier appli prepar weak solut commerci wet agent agral cittowett lubrol triton tween control solut prepar solvent dispers solubilis test substanc separ control group treat water treat solvent dispers procedur test control group number dose replic test meet statist requir determin ld confid limit dose geometr seri factor exceed cover rang ld requir test number dose determin relat slope toxic curv dose versu mortal consider statist method chosen analysi result rang find test enabl choic dose minimum replic test group bee dose test concentr minimum control batch bee run addit test seri organ solvent wet agent addit control batch bee solvent wet agent includ toxic standard toxic standard includ test seri dose select cover expect ld minimum replic cage bee test dose prefer toxic standard dimetho report contact ld rang ìg bee toxic standard accept suffici data provid verifi expect dose respons parathion exposur administr dose anaesthetis bee individu treat topic applic bee randomli assign test dose control volum ìl solut test substanc suitabl concentr appli microappl dorsal side thorax bee volum justifi applic bee alloc test cage suppli sucros solut durat durat test prefer mortal increas test durat extend maximum provid control mortal exce observ mortal record dose prolong observ period requir assess made interv maximum provid control mortal exceed abnorm behaviour effect observ test period record limit test case test substanc expect low toxic limit test perform ìg bee order demonstr ld greater procedur includ replic test group test dose relev control toxic standard mortal occur full studi conduct subleth effect observ section record data report data data summaris tabular form show treatment group control toxic standard group number bee mortal observ time number bee advers behaviour analys mortal data statist method probit analysi move averag binomi probabl plot dose respons curv recommend observ time relev calcul slope curv median lethal dose ld confid limit correct control mortal made abbott correct ld express ìg test substanc bee test report test report includ inform test substanc physic natur physic chemic properti stabil water vapour pressur chemic identif data includ structur formula puriti pesticid ident concentr activ substanc test speci scientif race approxim ag week collect method date collect inform coloni collect test bee includ health adult diseas pre treatment test condit temperatur rel humid experiment room hous condit includ type size materi cage method administr test substanc carrier solvent volum test solut appli anaesthet test design number test dose number control test dose control number replic cage number bee cage date test result result preliminari rang find studi perform raw data mortal concentr test observ time graph dose respons curv end test ld valu confid limit recommend observ time test substanc toxic standard statist procedur determin ld mortal control biolog effect observ measur abnorm respons bee deviat test method procedur relev inform refer eppo council europ decis make scheme environment risk assess plant protect product honeybe eppo bulletin vol pp march gough mcindo lewi dimetho refer compound laboratori acut toxic test honeybe api mellifera journal apicultur research pp litchfield wilcoxon simplifi method evalu dose effect experi jour pharmacol exper ther pp finnei probit analysi ed cambridg london york abbott method comput effect insecticid jour econ entomol pp adsorpt desorpt batch equilibrium method method method replic oecd tg determin soil adsorpt desorpt batch equilibrium method introduct method take account ring test workshop soil select develop adsorpt test exist guidelin nation level adsorpt desorpt studi gener essenti inform mobil chemic distribut soil water air compart biospher inform predict estim avail chemic degrad transform uptak organ leach soil profil volatil soil run land surfac natur water adsorpt data compar model purpos distribut chemic soil aqueou phase complex process depend number factor chemic natur substanc characterist soil climat factor rainfal temperatur sunlight wind numer phenomena mechan involv process adsorpt chemic soil complet defin simplifi laboratori model present method attempt cover environment case valuabl inform environment relev adsorpt chemic gener introduct scope method aim estim adsorpt desorpt behaviour substanc soil goal obtain sorption predict partit varieti environment condit end equilibrium adsorpt coeffici chemic soil determin function soil characterist organ carbon content clai content soil textur ph soil type order cover wide interact substanc natur occur soil method adsorpt repres process bind chemic surfac soil distinguish adsorpt process physic chemic adsorpt process surfac catalys degrad bulk adsorpt chemic reaction adsorpt occur colloid particl diamet amp lt ìm gener soil account soil paramet believ import adsorpt organ carbon content clai content soil textur ph ionis compound soil paramet impact adsorpt desorpt substanc effect cation exchang capac ecec content amorph iron aluminium oxid volcan tropic soil specif surfac test design evalu adsorpt chemic soil type vari rang organ carbon content clai content soil textur ph compris tier tier preliminari studi order determin soil solut ratio equilibrium time adsorpt amount test substanc adsorb equilibrium adsorpt test substanc surfac test vessel stabil test substanc test period tier screen test adsorpt studi soil type mean adsorpt kinet singl concentr determin distribut coeffici kd koc tier determin freundlich adsorpt isotherm determin influenc concentr extent adsorpt soil studi desorpt mean desorpt kinet freundlich desorpt isotherm appendix definit unit gt tabl gt principl test method volum solut test substanc label radiolabel concentr cacl ad soil sampl dry weight pre equilibr cacl mixtur agit time soil suspens separ centrifug wish filtrat aqueou phase analys amount test substanc adsorb soil sampl calcul differ amount test substanc initi present solut amount remain end experi indirect method option amount test substanc adsorb directli determin analysi soil direct method procedur involv step wise soil extract solvent recommend case differ solut concentr substanc accur determin exampl case adsorpt test substanc surfac test vessel instabl test substanc time scale experi weak adsorpt give small concentr chang solut strong adsorpt yield low concentr accur determin radiolabel substanc soil extract avoid analysi soil phase combust liquid scintil count liquid scintil count unspecif techniqu differenti parent transform product test chemic stabl durat studi inform test substanc chemic reagent analyt grade label test substanc composit prefer puriti radiolabel test substanc composit radio puriti recommend case short half life tracer decai correct appli carri test adsorpt desorpt inform test substanc water solubl vapour pressur henri law constant abiot degrad hydrolysi function ph partit coeffici readi biodegrad aerob anaerob transform soil pka ionis substanc direct photolysi water uv vi absorpt spectrum water quantum yield photodegrad soil applic test test applic chemic substanc analyt method suffici accuraci import paramet influenc reliabl result indirect method stabil test substanc time scale test prerequisit check stabil preliminari studi transform time scale test observ recommend main studi perform analys soil aqueou phase difficulti aris conduct test test substanc low water solubl sw amp lt highli charg substanc due fact concentr aqueou phase measur analyt suffici accuraci case addit step guidanc deal problem relev section method test volatil substanc care avoid loss studi descript method apparatu chemic reagent standard laboratori equip tube vessel conduct experi import tube vessel fit directli centrifug apparatu order minimis handl transfer error made inert materi minimis adsorpt test substanc surfac agit devic overhead shaker equival equip agit devic soil suspens shake centrifug prefer high speed centrifug forc amp gt temperatur control capabl remov particl diamet greater μm aqueou solut contain cap agit centrifug avoid volatil water loss minimis adsorpt deactiv cap teflon line screw cap option filtrat devic filter μm poros steril singl special care choic filter materi avoid loss test substanc poorli solubl test substanc organ filter materi recommend analyt instrument suitabl measur concentr test chemic laboratori oven capabl maintain temperatur characteris select soil soil characteris paramet consid larg respons adsorpt capac organ carbon clai content soil textur ph mention scope physico chemic properti soil impact adsorpt desorpt substanc consid case method soil characteris import signific influenc result recommend soil ph measur solut cacl solut adsorpt desorpt test iso method iso recommend relev soil properti determin standard method iso quot handbook soil analysi quot permit analysi sorption data base global standardis soil paramet guidanc exist standard method soil analysi characteris refer calibr soil test method refer soil recommend guidanc select soil adsorpt desorpt experi tabl select soil cover soil type encount temper geograph zone ionis test substanc select soil cover wide rang ph order evalu adsorpt substanc ionis unionis form guidanc soil stage test perform test soil type prefer characteris paramet similar variat properti tabl match criteria tabl guidanc select soil sampl adsorpt desorpt gt tabl gt collect storag soil sampl collect specif sampl techniqu tool recommend sampl techniqu depend purpos studi consid detail inform histori field site includ locat veget cover treatment pesticid fertilis biolog addit accident contamin recommend iso standard soil sampl iso respect descript sampl site sampl site defin utm univers transvers mercat project european horizont datum geograph coordin recollect soil futur defin soil classif system countri horizon maximum depth cm collect soil type horizon present part soil includ sampl soil sampl transport contain temperatur condit guarante initi soil properti significantli alter storag soil freshli field prefer soil store ambient temperatur air dri limit storag time recommend soil store year analys prior respect organ carbon content ph cec handl prepar soil sampl test soil air dri ambient temperatur prefer disaggreg perform minim forc origin textur soil chang soil siev particl size amp lt mm recommend iso standard soil sampl iso respect siev process care homogenis recommend enhanc reproduc result moistur content soil determin aliquot heat signific chang weight approxim calcul mass soil refer oven dry mass weight soil correct moistur content prepar test substanc applic soil test substanc dissolv solut cacl distil deionis water cacl solut aqueou solvent phase improv centrifug minimis cation exchang concentr stock solut prefer order magnitud higher detect limit analyt method threshold safeguard accur measur respect methodolog method addition stock solut concentr water solubl test substanc stock solut prefer prepar applic soil sampl close dark storag time depend stabil test substanc concentr solut poorli solubl substanc sw amp lt solubilis agent need difficult dissolv test substanc solubilis agent miscibl water methanol acetonitril concentr exce total volum stock solut constitut solut test substanc contact soil prefer surfact undergo solvolyt reaction test chemic solubilis agent stipul justifi report data altern poorli solubl substanc add test substanc test system spike test substanc dissolv organ solvent aliquot ad system soil solut cacl distil deionis water content organ solvent aqueou phase low exceed spike organ solut suffer volum unreproduc addit error introduc test substanc solvent concentr test prerequisit perform adsorpt desorpt test analyt method kei paramet influenc accuraci sorption measur includ accuraci analyt method analysi solut adsorb phase stabil puriti test substanc attain sorption equilibrium magnitud solut concentr chang soil solut ratio soil structur equilibr process exampl bear accuraci issu appendix reliabl analyt method check concentr rang occur test experiment feel free develop method accuraci precis reproduc detect limit recoveri guidanc perform test experi volum cacl cm agit weight soil high adsorb high organ carbon clai content weight volum vari depend analyt soil solut ratio conveni start point mixtur centrifug aqueou phase filtrat volum test substanc stock solut ad reach nomin concentr concentr rang occur test volum exce final volum aqueou phase order chang natur pre equilibr solut solut analys blank run consist system soil cacl solut test substanc includ order check artefact analyt method matrix effect caus soil analyt method sorption measur includ ga liquid chromatographi glc high perform liquid chromatographi hplc spectrometri gc mass spectrometri hplc mass spectrometri liquid scintil count radiolabel substanc independ analyt method consid suitabl recoveri nomin order detect evalu partit place detect limit analyt method order magnitud nomin concentr characterist detect limit analyt method carri adsorpt studi plai import role defin test condit experiment perform test method gener experiment path recommend guidanc altern solut analyt method laboratori facil impos limit select optim soil solut ratio select soil solut ratio sorption studi depend distribut coeffici kd rel degre adsorpt desir chang substanc concentr solut determin statist accuraci measur base form adsorpt equat limit analyt methodolog detect concentr chemic solut gener practic settl fix ratio percentag adsorb prefer amp gt care test substanc concentr aqueou phase high measur accur import case high adsorpt percentag conveni approach select soil water ratio base estim kd preliminari studi establish estim techniqu appendix select ratio made base plot soil solut ratio versu kd fix percentag adsorpt fig plot assum adsorpt equat linear applic relationship obtain rearrang equat kd form equat gt refer graphic gt logarithm form assum gt refer graphic gt gt refer graphic gt gt pic file quot en tif quot gt fig relationship soil solut ratio kd percentag adsorb test substanc fig show soil solut ratio requir function kd level adsorpt soil solut ratio kd approxim adsorpt occur obtain adsorpt kd ratio approach select soil solut ratio investig flexibl meet experiment area difficult deal chemic highli slightli adsorb low adsorpt occur soil solut ratio recommend organ soil type smaller ratio obtain slurri care analyt methodolog measur small solut concentr adsorpt measur inaccur hand high distribut coeffici kd soil solut ratio order leav signific amount chemic solut care ensur good mix adequ time allow system equilibr altern approach deal extrem case adequ analyt methodolog miss predict kd appli estim techniqu base pow valu appendix low adsorb polar chemic pow amp lt lipophil highli sorptiv chemic pow amp gt perform test test condit experi ambient temperatur constant temperatur centrifug condit remov particl larger μm solut trigger smallest size particl consid solid particl limit solid colloid particl guidanc determin centrifug condit appendix centrifug facil guarante remov particl larger μm combin centrifug filtrat μm filter filter made suitabl inert materi avoid loss test substanc case proven loss test substanc occur filtrat tier preliminari studi purpos conduct preliminari studi section scope guidanc set test experi suggest select optim soil solut ratio soil type soil solut ratio experi soil type high organ carbon low clai content low organ carbon high clai content soil solut ratio suggest soil cm aqueou solut test substanc ratio soil cm aqueou solut test substanc ratio soil cm aqueou solut test substanc ratio minimum amount soil experi carri depend laboratori facil perform analyt method recommend prefer order obtain reliabl result test control sampl test substanc cacl solut soil subject precis step test system order check stabil test substanc cacl solut adsorpt surfac test vessel blank run soil amount soil total volum cm cacl solut test substanc subject test procedur serv background control analysi detect interf substanc contamin soil experi includ control blank perform duplic total number sampl prepar studi calcul respect methodolog method preliminari studi main studi gener except mention relev air dri soil sampl equilibr shake minimum volum cm cacl overnight dai experi volum stock solut test substanc ad order adjust final volum cm volum stock solut ad exce final cm volum aqueou phase order chang natur pre equilibr solut prefer result initi concentr test substanc contact soil order magnitud higher detect limit analyt method threshold safeguard abil perform accur measur strong adsorpt occur amp gt determin adsorpt isotherm recommend initi substanc concentr exce half solubl limit calcul concentr stock solut cst detect limit μg cm adsorpt assum initi concentr test substanc contact soil prefer μg cm order magnitud higher detect limit suppos maximum recommend volum stock solut ad cm cacl equilibr solut stock solut cm total volum aqueou phase concentr stock solut μg cm order magnitud higher detect limit analyt method ph aqueou phase measur contact soil plai import role adsorpt process ionis substanc mixtur shaken adsorpt equilibrium reach equilibrium time soil highli variabl depend chemic soil period gener suffici preliminari studi sampl collect sequenti period mix time analysi consid flexibl respect work schedul laboratori option analysi test substanc aqueou solut parallel method serial method stress parallel method experiment tediou mathemat treatment result simpler appendix choic methodolog left experiment laboratori facil resourc parallel method sampl soil solut ratio prepar time interv desir studi adsorpt kinet centrifug wish filtrat aqueou phase tube recov complet measur tube serial method duplic sampl prepar soil solut ratio defin time interv mixtur centrifug separ phase small aliquot aqueou phase immedi analys test substanc experi continu origin mixtur filtrat appli centrifug laboratori facil handl filtrat small aqueou aliquot recommend total volum aliquot exce total volum solut order chang significantli soil solut ratio decreas mass solut adsorpt test percentag adsorpt ati calcul time point ti basi nomin initi concentr measur concentr sampl time ti correct blank plot ati versu time fig appendix gener order estim achiev equilibrium plateau kd equilibrium calcul base kd soil solut ratio select fig percentag adsorpt reach prefer amp gt applic equat principl plot section data report appendix determin adsorpt equilibr time amount test substanc adsorb equilibrium mention plot ati caqad versu time permit estim achiev adsorpt equilibrium amount test substanc adsorb equilibrium fig appendix show exampl plot equilibr time system reach plateau soil plateau steadi increas found due complic factor biodegrad slow diffus biodegrad shown repeat experi sterilis sampl soil plateau achiev case experiment search phenomena involv specif studi modif experi condit temperatur shake time soil solut ratio left experiment decid continu test procedur spite failur achiev equilibrium adsorpt surfac test vessel stabil test substanc inform adsorpt test substanc surfac test vessel stabil deriv analys control sampl deplet standard error analyt method observ abiot degrad adsorpt surfac test vessel involv distinct phenomena achiev wash wall vessel volum solvent subject wash solut analysi test substanc adsorpt surfac test vessel observ deplet demonstr abiot unstabl test substanc adsorpt found chang materi test vessel data adsorpt surfac test vessel gain experi directli extrapol soil solut experi presenc soil affect adsorpt addit inform stabil test substanc deriv determin parent mass balanc time mean aqueou phase extract soil test vessel wall analys test substanc differ mass test chemic ad sum test chemic mass aqueou phase extract soil test vessel wall equal mass degrad volatilis extract order perform mass balanc determin adsorbion equilibrium reach period experi mass balanc perform soil soil solut ratio soil deplet prefer amp gt equilibrium ratio find experi complet analysi sampl aqueou phase phase separ centrifug wish filtrat aqueou phase recov suitabl extract solvent extract coeffici ad soil extract test substanc success extract recommend amount test substanc soil test vessel extract determin mass balanc calcul equat data report test substanc consid unstabl time scale test studi continu take account unstabl test substanc case recommend analys phase main studi tier adsorpt kinet concentr test substanc soil select tabl advantag includ soil preliminari studi soil case tier repeat soil preliminari studi equilibr time soil solut ratio weight soil sampl volum aqueou phase contact soil concentr test substanc solut chosen base preliminari studi result analysi prefer approxim possibl contact time agit time extend maximum case chemic requir longer equilibr time respect ratio find result time analysi consid flexibl experi soil solut duplic estim varianc result experi blank run consist soil cacl solut test substanc weight volum ident experi control sampl test substanc cacl solut soil subject test procedur serv safeguard unexpect percentag adsorpt calcul time point ati time interv aδti plot versu time distribut coeffici kd equilibrium organ carbon normalis adsorpt coeffici koc polar organ chemic calcul result adsorpt kinet test linear kd gener accur describ sorptiv behaviour soil repres express inher mobil chemic soil gener chemic kd amp lt cm consid qualit mobil similarli mobil classif scheme base koc valu develop maccal al addition leach classif scheme exist base relationship koc dt error analysi studi kd valu cm estim accur decreas concentr aqueou phase favour point view accuraci soil solut ratio appli case analysi phase soil solut recommend respect remark recommend studi adsorpt behaviour chemic soil potenti mobil continu determin freundlich adsorpt isotherm system accur determin kd experiment protocol test method accur determin result multipli kd soil solut ratio amp gt measur base concentr decreas aqueou phase indirect method amp gt phase analys direct method tier adsorpt isotherm desorpt kinet desorpt isotherm adsorpt isotherm test substanc concentr cover prefer order magnitud choic concentr water solubl result aqueou equilibrium concentr account soil solut ratio soil studi adsorpt test perform differ aqueou phase analys time reach equilibrium determin tier equilibrium concentr solut determin amount adsorb calcul deplet test substanc solut direct method adsorb mass unit mass soil plot function equilibrium concentr test substanc data report result adsorpt isotherm experi mathemat adsorpt model propos freundlich isotherm frequent describ adsorpt process detail inform interpret import adsorpt model provid refer note mention comparison kf freundlich adsorpt coeffici valu substanc kf valu express unit desorpt kinet purpos experi investig chemic revers irrevers adsorb soil inform import desorpt process plai import role behaviour chemic field soil desorpt data input comput model leach dissolv run simul desorpt studi desir recommend studi carri system accur determin kd preced adsorpt kinet experi likewis adsorpt kinet studi option proce desorpt kinet experi parallel method serial method choic methodolog left experiment laboratori facil resourc parallel method soil chosen proce desorpt studi sampl soil solut ratio prepar time interv desir studi desorpt kinet prefer time interv adsorpt kinet experi total time extend order system reach desorpt equilibrium experi soil solut blank run consist soil cacl solut test substanc weight volum ident experi control sampl test substanc cacl solut soil subject test procedur mixtur soil solut agit reach adsorpt equilibrium determin tier phase separ centrifug aqueou phase remov volum solut remov replac equal volum cacl test substanc mixtur agit aqueou phase tube recov complet measur tube desorpt equilibrium reach serial method adsorpt kinet experi mixtur centrifug aqueou phase remov volum solut remov replac equal volum cacl test substanc mixtur agit desorpt equilibrium reach time period defin time interv mixtur centrifug separ phase small aliquot aqueou phase immedi analys test substanc experi continu origin mixtur volum individu aliquot total volum quantiti fresh cacl solut ad mixtur maintain soil solut ratio agit continu time interv percentag desorpt calcul time point dti time interv dδti studi plot versu time desorpt coeffici kde equilibrium calcul applic equat data report appendix result desorpt kinet experi common plot percentag desorpt dti adsorpt ati versu time estim revers adsorpt process desorpt equilibrium attain time adsorpt equilibrium total desorpt amount adsorb adsorpt consid revers desorpt isotherm freundlich desorpt isotherm determin soil adsorpt isotherm experi desorpt test perform section desorpt kinet differ aqueou phase analys desorpt equilibrium amount test substanc desorb calcul content test substanc remain adsorb soil desorpt equilibrium plot function equilibrium concentr test substanc solut data report appendix data report analyt data present tabular form appendix individu measur averag calcul graphic represent adsorpt isotherm provid calcul made purpos test consid weight cm aqueou solut soil solut ratio express unit vol figur adsorpt adsorpt ati defin percentag substanc adsorb soil relat quantiti present begin test test condit test substanc stabl adsorb significantli contain wall ati calcul time point ti equat gt refer graphic gt ati adsorpt percentag time point ti gt refer graphic gt mass test substanc adsorb soil time ti μg mass test substanc test tube begin test μg detail inform calcul percentag adsorpt ati parallel serial method appendix distribut coeffici kd ratio content substanc soil phase mass concentr substanc aqueou solut test condit adsorpt equilibrium reach gt refer graphic gt gt refer graphic gt content substanc adsorb soil adsorpt equilibrium μg gt refer graphic gt mass concentr substanc aqueou phase adsorpt equilibrium μg cm concentr analyt determin take account valu blank gt refer graphic gt mass substanc adsorb soil adsorpt equilibrium μg gt refer graphic gt mass substanc solut adsorpt equilibrium μg msoil quantiti soil phase express dry mass soil initi volum aqueou phase contact soil cm relat aeq kd gt refer graphic gt aeq percentag adsorpt adsorpt equilibrium organ carbon normalis adsorpt coeffici koc relat distribut coeffici kd content organ carbon soil sampl gt refer graphic gt oc percentag organ carbon soil sampl koc coeffici repres singl characteris partit polar organ chemic organ carbon soil sediment water adsorpt chemic correl organ content sorb solid koc valu depend specif characterist humic fraction differ consider sorption capac due differ origin genesi adsorpt isotherm freundlich adsorpt isotherm equat relat amount test substanc adsorb concentr test substanc solut equilibrium equat data treat quot adsorpt quot test tube content test substanc adsorb soil adsorpt test gt refer graphic gt denot calcul assum equilibrium attain gt refer graphic gt repres equilibrium gt refer graphic gt freundlich adsorpt equat shown gt refer graphic gt linear form gt refer graphic gt kfad freundlich adsorpt coeffici dimens cm case slope introduc dimens gt refer graphic gt regress constant gener rang indic sorption data frequent slightli linear equat plot valu kfad calcul regress analysi equat correl coeffici log equat calcul plot fig gt pic file quot en tif quot gt fig freundlich adsorpt plot normal linearis mass balanc mass balanc mb defin percentag substanc analyt recov adsorpt test versu nomin amount substanc begin test treatment data differ solvent complet miscibl water case water miscibl solvent treatment data quot desorpt quot appli determin amount substanc recov solvent extract solvent miscibl water determin amount recov made mass balanc mb adsorpt calcul assum term correspond sum test chemic mass extract soil surfac test vessel organ solvent gt refer graphic gt mb mass balanc total mass test substanc extract soil wall test vessel step μg initi mass concentr test solut contact soil μg cm vrec volum supernat recov adsorpt equilibrium cm desorpt desorpt defin percentag test substanc desorb relat quantiti substanc previous adsorb test condit gt refer graphic gt dti desorpt percentag time point ti gt refer graphic gt mass test substanc desorb soil time point ti μg gt refer graphic gt mass test substanc adsorb soil adsorpt equilibrium μg detail inform calcul percentag desorpt dti parallel serial method appendix appar desorpt coeffici kde test condit ratio content substanc remain soil phase mass concentr desorb substanc aqueou solut desorpt equilibrium reach gt refer graphic gt kde desorpt coeffici cm gt refer graphic gt total mass test substanc desorb soil desorpt equilibrium μg vt total volum aqueou phase contact soil desorpt kinet test cm guidanc calcul gt refer graphic gt appendix head quot desorpt quot remark adsorpt test preced perform parallel method volum vt equat consid equal desorpt isotherm freundlich desorpt isotherm equat relat content test substanc remain adsorb soil concentr test substanc solut desorpt equilibrium equat test tube content substanc remain adsorb soil desorpt equilibrium calcul gt refer graphic gt gt refer graphic gt defin gt refer graphic gt gt refer graphic gt content test substanc remain adsorb soil desorpt equilibrium μg gt refer graphic gt mass substanc determin analyt aqueou phase desorpt equilibrium μg gt refer graphic gt mass test substanc left adsorpt equilibrium due incomplet volum replac μg gt refer graphic gt mass substanc solut adsorpt equilibrium μg gt refer graphic gt vrf volum solut tube measur test substanc desorpt equilibrium cm vr volum supernat remov tube attain adsorpt equilibrium replac volum cacl solut cm freundlich desorpt equat shown gt refer graphic gt linear form gt refer graphic gt gt refer graphic gt freundlich desorpt coeffici regress constant gt refer graphic gt mass concentr substanc aqueou phase desorpt equilibrium μg cm equat plot kfde calcul regress analysi equat remark freundlich adsorpt desorpt expon equal freundlich adsorpt desorpt bind constant kfad kfde equal adsorpt desorpt equilibrium constant kd kde plot cs caq linear expon equal plot cs caq linear adsorpt desorpt constant vari isotherm testreport test report includ inform complet identif soil sampl includ geograph refer site latitud longitud date sampl pattern agricultur soil forest depth sampl sand silt clai content ph valu cacl organ carbon content organ matter content nitrogen content ratio cation exchang capac mmol kg inform relat collect storag soil sampl relev inform interpret adsorpt desorpt test substanc refer method determin paramet inform test substanc temperatur experi centrifug condit analyt procedur analys test substanc justif solubilis agent prepar stock solut test substanc explan correct made calcul relev data form sheet appendix graphic present inform observ help interpret test result refer kukowski brümmer investig adsorpt desorpt select chemic soil uba report part ii fränzle kuhnt vetter select repres soil ec territori uba report part kuhnt muntau ed euro soil identif collect treatment characteris special public joint research centr european commiss ispra decemb oecd test guidelin programm final report oecd workshop select soil sediment belgir itali januari june environ protect agenc pesticid assess guidelin subdivis chemistri environment fate seri leach adsorpt desorpt studi addendum data report date environ protect agenc prevent pesticid toxic substanc oppt harmon test guidelin seri fate transport transform test guidelin ppt sediment soil adsorpt desorpt isotherm epa april astm standard standard test method determin sorption constant koc organ chemic soil sediment agricultur canada environment chemistri fate guidelin registr pesticid canada juli netherland commiss registr pesticid applic registr pesticid section behaviour product metabolit soil water air danish nation agenc environment protect octob criteria registr pesticid danger health harm environ bba guidelin offici test plant protect product biolog research centr agricultur forestri braunschweig germani calvet quot evalu adsorpt coeffici predict mobil pesticid soil quot methodolog aspect studi pesticid behaviour soil ed jamet inra pari review calvet quot adsorpt desorpt phenomena quot interact herbicid soil hanc ed academ press london pp hasset banwart quot sorption nonpolar organ soil sediment quot reaction movement organ chemic soil soil scienc societi america special public pp van genuchten davidson wierenga quot evalu kinet equilibrium equat predict pesticid movement porou media quot soil sci soc proc vol pp mccall laskowski swann dishburg quot measur sorption coeffici organ chemic environment fate analysi quot test protocol environment fate movement toxic proceed aoac symposium aoac washington dc lambert porter schieferrstein quot movement sorption chemic appli soil quot weed pp rhode belasco peas quot determin mobil adsorpt agrochem soil quot agric food chem pp russel quot recommend approach assess pesticid mobil soil quot environment behavior agrochem ed robert kearnei john wilei amp son esser hemingwai klein sharp vonk holland quot recommend approach evalu environment behavior pesticid quot iupac report pesticid pure appl chem pp guth burkhard eberl quot experiment model studi persist pesticid soil quot proc bcpc symposium persist insecticid herbicid pp bcpc surrei uk furming osgerbi quot persist herbicid soil quot sci fd agric pp burkhard guth quot chemic hydrolysi chloro bi alkylamino triazin herbicid breakdown soil influenc adsorpt quot pestic sci pp guth gerber schlaepfer quot effect adsorpt movement persist biolog avail soil appli pesticid quot proc br crop prot conf pp osgerbi quot process affect herbicid action soil quot pestic sci pp guth quot adsorpt und einwascheverhalten von pflanzenschutzmitteln böden quot schr reih ver wass boden lufthyg berlin dahlem heft pp hamak quot interpret soil leach experi quot environment dynam pesticid ed haqu freed pp plenum press ny hell quot pesticid mobil soil quot soil sci soc amer proc pp hamak quot diffus volatil quot organ chemic soil environ gore hamak ed vol pp burkhard guth quot rate volatilis pesticid soil surfac comparison calcul result determin laboratori model system quot pestic sci pp cohen creeger carsel enfield quot potenti pesticid contamin groundwat agricultur quot treatment dispos pesticid wast pp ac symp ser american chemic societi washington dc gustafson quot groundwat ubiqu score simpl method assess pesticid leachabl quot environ toxic chem pp leistra dekker quot comput effect adsorpt kinet pesticid movement soil quot soil sci pp bromilov leistra quot measur simul behavior aldicarb oxyd product fallow soil quot pest sci pp green karickoff quot sorption estim model quot pesticid soil environ process impact model ed cheng soil sci soc book seri pp lambert quot function relationship sorption soil chemic structur quot agri food chem pp hanc quot empir relationship chemic structur sorption herbicid soil quot agri food chem pp brigg quot molecular structur herbicid sorption soil quot natur brigg quot theoret experiment relationship soil adsorpt octanol water partit coeffici water solubl bioconcentr factor parachor quot agric food chem pp sabljic quot predict natur strength soil sorption organ polut molecular topolog quot agric food chem pp bailei white quot factor influenc adsorpt desorpt movement pesticid soil quot residu rev pp bailei white rothberg quot adsorpt organ herbicid montomorillonit role ph chemic charact adsorb quot soil sci soc amer proc pp karickhoff quot semi empir estim sorption hydrophob pollut natur sediment soil quot chemospher pp paya perez riaz larsen quot soil sorption chlorobenzen pcb congen quot environ toxicol safeti pp hamak thompson quot adsorpt organ chemic quot organ chemic soil environ gore hamak ed vol ii marcel dekker york ny pp deli warren quot adsorpt desorpt leach diphenamid soil quot weed sci pp chu huang wu buehr davinson santelmann quot napropamid adsorpt desorpt movement soil quot weed scienc vol pp haue stacei thompson quot adsorpt triazin herbicid soil organ prepar quot isotop radiat soil organ studi intern atom energi agenc vienna pionk deang quot method distribut pesticid loss field run solut adsorb phase quot cream field scale model chemic run eros agricultur manag system chapter vol iii support document usda conserv research report iso standard compendium environ soil qualiti gener aspect chemic physic method analysi biolog method analysi edit scheffer schachtschabel lehrbuch der bodenkund enk verlag stuttgart edit black evan white ensming clark ed quot method soil analysi quot vol american societi agronomi madison wi iso di soil qualiti sampl part guidanc design sampl programm iso di soil qualiti sampl part guidanc sampl techniqu iso di soil qualiti sampl part guidanc safeti sampl iso di soil qualiti sampl part guidanc investig natur cultiv soil iso di soil qualiti sampl part guidanc investig soil contamin urban industri site iso soil qualiti sampl part guidanc collect handl storag soil assess aerob microbi process laboratori green yaman quot precis pesticid adsorpt measur quot soil sci proc pp grover hanc quot effect ratio soil water adsorpt linuron atrazin quot soil sci pp boesten quot influenc soil liquid ratio experiment error sorption coeffici pesticid soil system quot pest sci pp boesten quot influenc soil liquid ratio experiment error sorption coeffici relat oecd guidelin quot proceed intern workshop environment behaviour pesticid regulatori aspect brussel april bastid cantier cost quot comport de substanc herbicid dan le sol en fonction de leur structur chimiqu quot weed re pp brown flagg quot empir predict organ pollut sorption natur sediment quot environ qual pp chiou porter schmed quot partit equilibria ionic organ compound soil organ matter water quot environ sci technol pp gerstl mingelgrin quot sorption organ substanc soil sediment quot environm sci health pp vowl mantoura quot sediment water partit coeffici hplc retent factor aromat hydrocarbon quot chemospher pp lyman reehl rosenblatt handbook chemic properti estim method environment behaviour organ compound american chemic societi washington dc keniga gore quot relationship water solubl soil sorption octanol water partit concentr chemic biota quot aquat toxicolog ed eaton al pp astm stp philadelphia chiou peter freed quot physic concept soil water equilibria ionic organ compound quot scienc vol pp hassett banwart wood mean quot sorption naphtol implic limit hydrophob sorption quot soil sci soc pp karickhoff quot semi empir estim sorption hydrophob pollut natur sediment soil quot chemospher vol pp moreal van bladel quot adsorpt de herbicid insecticid par le sol relat solubilité reactivité quot revu de agric pp müller kördel quot comparison screen method determin estim adsorpt coeffici soil quot chemospher pp kördel kotthoff müller quot hplc screen method determin adsorpt coeffici soil result ring test quot chemospher pp kördel stutt kotthoff quot hplc screen method determin adsorpt coeffici soil comparison stationari phase quot chemospher pp hanc quot speed attain sorption equilibria system involv herbicid quot weed research vol pp koskinen harper quot retent process mechan quot pesticid soil environ process impact model ed cheng soil sci soc book seri madison wisconsin cohen creeger carsel enfield quot potenti pesticid contamin groundwat agricultur quot treatment dispos pesticid wast pp ac symp ser american chemic societi washington dc gile quot interpret sorption isotherm quot sorption transport process soil monograph pp gile mcewan nakhwa smith quot studi adsorpt xi system classif solut adsorpt isotherm diagnosi adsorpt mechan measur pesticid surfac area soil quot chem soc pp calvet tercé arvien quot adsorpt de pesticid par le sol leur constitu caractéristiqu générale de adsorpt quot ann agron pp bedbur quot anomali freundlich equat quot proc cost workshop pesticid soil environ stratford avon uk guth quot adsorpt desorpt quot joint intern symposium physicochem properti role environment hazard assess juli canterburi uk soil textur classif fao system weed scienc suppl soil sci soc amer proc appendix test scheme gt pic file quot en tif quot gt appendix influenc accuraci analyt method concentr chang accuraci adsorpt result gt pic file quot en tif quot gt appendix estim techniqu kd estim techniqu permit predict kd base correl pow valu water solubl data polar data deriv applic hplc revers phase shown tabl koc kom calcul equat indirectli kd equat gt refer graphic gt gt refer graphic gt concept correl base assumpt organ matter soil influenc adsorpt substanc interact involv polar result correl extent applic polar substanc applic case organ matter content soil small addit satisfactori correl found pow adsorpt relationship water solubl extent adsorpt studi contradictori exampl correl adsorpt coeffici octanol water partit coeffici water solubl tabl gt tabl gt gt tabl gt appendix calcul defin centrifug condit centrifug time formula assum spheric particl gt refer graphic gt simplif purpos paramet si unit cm rotat speed rpm rad rpm revolut minut viscos solut cm rp particl radiu cm ρs soil densiti cm ρaq solut densiti cm rt distanc centr centrifug rotor top solut centrifug tube cm rb distanc centr centrifug rotor bottom centrifug tube cm rb rt length soil solut mixtur centrifug tube cm gener practic doubl calcul time ensur complet separ equat simplifi viscos densiti ρaq solut equal viscos densiti water cm ρaq cm centrifug time equat gt refer graphic gt equat appar paramet import defin centrifug condit time speed rpm order achiev separ particl specif size case μm radiu densiti soil length mixtur centrifug tube rb rt distanc soil particl cover top solut bottom tube fix volum length mixtur tube depend squar radiu tube fig present variat centrifug time versu centrifug speed rpm soil densiti ρs fig length mixtur centrifug tube fig fig influenc soil densiti appear obviou classic centrifug rpm centrifug time approxim min cm soil densiti min cm similarli fig classic centrifug rpm centrifug time approxim min length mixtur cm min length cm import find optim relat centrifug requir length easi handl experiment separ phase centrifug defin experiment condit separ soil solut phase import exist quot pseudo phase quot colloid particl size μm import impact adsorpt mechan substanc soil suspens centrifug perform colloid remain aqueou phase subject analysi aqueou phase inform impact lost conduct laboratori ultracentrifug ultrafiltr facil adsorpt desorpt substanc soil studi depth includ inform adsorpt substanc colloid case ultracentrifug rpm min ultrafiltr filter poros dalton appli order separ phase soil colloid solut test protocol modifi order phase subject substanc analysi gt pic file quot en tif quot gt fig variat centrifug time versu centrifug speed rpm soil densiti ρs rt cm rb rt cm cm ρaq cm gt pic file quot en tif quot gt fig variat centrifug time versu centrifug speed rpm length mixtur centrifug tube rb rt rt cm cm ρaq cm ρs cm appendix calcul adsorpt desorpt time scheme procedur gt pic file quot en tif quot gt calcul assum test substanc stabl adsorb significantli contain wall adsorpt parallel method percentag adsorpt calcul test tube time point ti equat gt refer graphic gt term equat calcul gt refer graphic gt gt refer graphic gt ati adsorpt percentag time point ti gt refer graphic gt mass test substanc soil time ti analysi perform μg mass test substanc test tube begin test μg initi mass concentr test solut contact soil μg cm gt refer graphic gt mass concentr substanc aqueou phase time ti analysi perform μg cm concentr analyt determin take account valu blank initi volum test solut contact soil cm valu adsorpt percentag ati gt refer graphic gt plot versu time time sorption equilibrium attain determin exampl plot fig fig gt pic file quot en tif quot gt fig adsorpt equilibrium plot gt pic file quot en tif quot gt fig mass concentr test substanc aqueou phase caq versu time serial method equat account adsorpt procedur carri measur test substanc small aliquot aqueou phase specif time interv time interv amount substanc adsorb soil calcul time interv δti ti gt refer graphic gt time interv δt gt refer graphic gt time interv δt gt refer graphic gt nth time interv δtn tn tn gt refer graphic gt percentag adsorpt time interv aδti calcul equat gt refer graphic gt percentag adsorpt ati time point ti equat gt refer graphic gt valu adsorpt ati aδti respect studi plot versu time time sorption equilibrium attain determin equilibr time teq mass test substanc adsorb soil gt refer graphic gt mass test substanc solut gt refer graphic gt percentag adsorpt equilibrium gt refer graphic gt paramet defin gt refer graphic gt gt refer graphic gt gt refer graphic gt mass substanc adsorb soil time interv δt δt δtn μg gt refer graphic gt gt refer graphic gt gt refer graphic gt mass substanc measur aliquot gt refer graphic gt time point tn μg gt refer graphic gt mass substanc adsorb soil adsorpt equilibrium μg gt refer graphic gt mass substanc solut adsorpt equilibrium μg gt refer graphic gt volum aliquot test substanc measur cm aδti percentag adsorpt time interv δti aeq percentag adsorpt adsorpt equilibrium desorpt time desorpt kinet experi begin consid moment maxim recov volum test substanc solut adsorpt equilibrium attain replac equal volum cacl solut parallel method time point ti mass test substanc measur aqueou phase tube gt refer graphic gt mass desorb calcul equat gt refer graphic gt desorpt equilibrium ti teq gt refer graphic gt mass test substanc desorb time interv δti equat gt refer graphic gt percentag desorpt calcul time point ti equat gt refer graphic gt time interv δti equat gt refer graphic gt dti desorpt percentag time point ti dδti desorpt percentag time interv δti gt refer graphic gt mass test substanc desorb time point ti μg gt refer graphic gt mass test substanc desorb time interv δti μg gt refer graphic gt mass test substanc analyt measur time ti solut volum vri analysi μg gt refer graphic gt mass test substanc left adsorpt equilibrium due incomplet volum replac μg gt refer graphic gt gt refer graphic gt mass test substanc solut adsorpt equilibrium μg vr volum supernat remov tube attain adsorpt equilibrium replac volum cacl solut cm gt refer graphic gt volum solut tube measur test substanc desorpt kinet experi cm valu desorpt dti dδti studi plot versu time time desorpt equilibrium attain determin serial method equat account adsorpt procedur preced carri measur test substanc small aliquot gt refer graphic gt aqueou phase serial method perform test assum volum supernat remov tube adsorpt kinet experi replac volum cacl solut vr total volum aqueou phase contact soil vt desorpt kinet experi remain constant equat gt refer graphic gt time point ti mass test substanc measur small aliquot gt refer graphic gt mass desorb calcul equat gt refer graphic gt desorpt equilibrium ti teq gt refer graphic gt percentag desorpt dti calcul equat gt refer graphic gt time interv δti time interv amount substanc desorb calcul time interv δt gt refer graphic gt gt refer graphic gt time interv δt gt refer graphic gt gt refer graphic gt nth interv δtn tn tn gt refer graphic gt gt refer graphic gt final percentag desorpt time interv dδti calcul equat gt refer graphic gt percentag desorpt dti time point ti equat gt refer graphic gt paramet defin gt refer graphic gt gt refer graphic gt gt refer graphic gt mass substanc remain adsorb soil time interv δt δt δtn μg gt refer graphic gt gt refer graphic gt gt refer graphic gt mass test substanc desorb time interv δt δtn μg gt refer graphic gt gt refer graphic gt gt refer graphic gt mass substanc measur aliquot gt refer graphic gt time point tn μg vt total volum aqueou phase contact soil desorpt kinet experi perform serial method cm gt refer graphic gt mass test substanc left adsorpt equilibrium due incomplet volum replac μg gt refer graphic gt vr volum supernat remov tube attain adsorpt equilibrium replac volum cacl solut cm gt refer graphic gt volum aliquot sampl analyt purpos tube desorpt kinet experi perform serialmethod cm gt refer graphic gt equat applic direct indirect method equat applic indirect method equat applic direct indirect method equat applic indirect method equat applic direct indirect method equat applic indirect method equat applic direct indirect method equat applic indirect method equat applic direct indirect method equat applic indirect method equat applic direct indirect method equat applic indirect method appendix adsorpt desorpt soil data report sheet gt pic file quot en tif quot gt gt pic file quot en tif quot gt gt pic file quot en tif quot gt gt pic file quot en tif quot gt gt pic file quot en tif quot gt gt pic file quot en tif quot gt estim adsorpt coeffici koc soil sewag sludg high perform liquid chromatographi hplc method method replic oecd tg introduct sorption behavior substanc soil sewag sludg paramet experiment determin mean test method import paramet adsorpt coeffici defin ratio concentr substanc soil sludg concentr substanc aqueou phase adsorpt equilibrium adsorpt coeffici normalis organ carbon content soil koc indic bind capac chemic organ matter soil sewag sludg comparison made chemic paramet estim correl water solubl octanol water partit coeffici experiment method test hplc estim adsorpt coeffici koc soil sewag sludg estim higher reliabl qsar calcul estim method fulli replac batch equilibrium experi test method estim koc choos test paramet adsorpt desorpt studi test method calcul kd distribut coeffici kf freundlich adsorpt coeffici equat section definit kd distribut coeffici defin ratio equilibrium concentr dissolv test substanc phase system consist sorbent soil sewag sludg aqueou phase dimensionless concentr phase express weight weight base case concentr aqueou phase weight volum base unit ml kd vari sorbent properti concentr depend gt refer graphic gt csoil concentr test substanc soil equilibrium μg csludg concentr test substanc sludg equilibrium μg caq concentr test substanc aqueou phase equilibrium μg μg ml kf freundlich adsorpt coeffici defin concentr test substanc soil sewag sludg equilibrium concentr caq aqueou phase equal unit μg sorbent vari sorbent properti gt refer graphic gt amount test substanc μg adsorb amount sorbent equilibrium slope freundlich adsorpt isotherm caq concentr test substanc aqueou phase equilibrium μg ml gt refer graphic gt gt refer graphic gt koc distribut coeffici kd freundlich adsorpt coeffici kf normalis organ carbon content foc sorbent ionis chemic approxim indic extent adsorpt substanc sorbent comparison made chemic depend dimens kd kf koc dimensionless unit ml μg organ matter gt refer graphic gt relationship koc kd linear koc valu vari soil soil variabl greatli reduc compar kd kf valu adsorpt coeffici koc deduc capac factor calibr plot log versu log koc select refer compound gt refer graphic gt tr hplc retent time test refer substanc minut hplc dead time minut section pow octanol water partit coeffici defin ratio concentr dissolv substanc octanol water dimensionless gt refer graphic gt refer substanc structur formula puriti dissoci constant method inform solubl water organ solvent octanol water partit coeffici hydrolysi characterist correl measur hplc retent data test substanc adsorpt coeffici koc calibr graph log koc versu log establish minimum refer point expect test substanc accuraci method significantli improv refer substanc structur relat test substanc data user select calibr substanc gener set structur heterogen substanc chosen case substanc koc valu list appendix tabl sewag sludg tabl soil select calibr substanc justifi principl test method hplc perform analyt column pack commerci cyanopropyl solid phase lipophil polar moieti moder polar stationari phase base silica matrix gt pic file quot en tif quot gt principl test method similar test method partit coeffici hplc method pass column mobil phase test substanc interact stationari phase result partit mobil stationari phase test substanc retard dual composit stationari phase polar polar site interact polar polar group molecul similar case organ matter soil sewag sludg matric enabl relationship retent time column adsorpt coeffici organ matter establish ph signific influenc sorption behavior polar substanc agricultur soil tank sewag treatment plant ph vari ph ionis substanc test perform ionis ionis form buffer solut case test compound dissoci ph relationship retent hplc column adsorpt coeffici emploi evalu quantit analyt method requir determin retent time suitabl set refer substanc standard experiment condit method fast effici estim adsorpt coeffici koc applic test hplc method applic chemic substanc unlabel label detect system spectrophotomet radioact detector suffici stabl durat experi chemic difficult studi experiment system volatil substanc substanc solubl water concentr measur analyt substanc high affin surfac incub system method mixtur give unresolv elut band case upper lower limit log koc valu compound test mixtur state impur problem interpret hplc result minor import long test substanc analyt identifi separ impur method valid substanc list tabl appendix appli varieti chemic belong chemic class aromat amin trifluralin chloroanilin dinitroanilin methylanilin methylanilin naphthylamin aromat carboxil acid ester benzoic acid methylest dinitrobenzo acid ethylest aromat hydrocarbon toluen xylen ethylbenzen nitrobenzen aryloxyphenoxypropion acid ester diclofop methyl fenoxaprop ethyl fenoxaprop ethyl benzimidazol imidazol fungicid carbendazim fuberidazol triazoxid carboxil acid amid chlorobenzamid dimethylbenzamid dinitrobenzamid methylbenzamid nitrobenzamid nitrobenzamid chlorin hydrocarbon endosulfan ddt hexachlorobenzen quintozen trichlorobenzen organophosphoru insecticid azinpho methyl disulfoton fenamipho isofenpho pyrazopho sulprofo triazopho phenol phenol nitrophenol nitrophenol pentachlorophenol trichlorophenol naphthol phenylurea deriv isoproturon monolinuron pencycuron pigment dyestuff acid yellow basic blue direct red polyaromat hydrocarbon acenaphthen naphthalen triazin herbicid prometryn propazin simazin terbutryn triazol deriv tebuconazol triadimefon tradimenol triapenthenol method applic substanc react eluent stationari phase applic substanc interact specif inorgan compon format cluster complex clai miner method work surfac activ substanc inorgan compound moder strong organ acid base log koc valu rang determin ionis substanc measur buffer mobil phase care avoid precipit buffer compon test substanc qualiti criteria accuraci adsorpt coeffici test substanc estim log unit determin batch equilibrium method tabl appendix higher accuraci achiev refer substanc structur relat test substanc repeat determin run duplic valu log koc deriv individu measur rang log unit reproduc experi gain applic method support valid investig hplc method substanc pesticid reliabl data koc soil gave correl coeffici inter laboratori comparison test particip laboratori perform improv valid method result tabl appendix descript test method preliminari estim adsorpt coeffici octanol water partit coeffici pow kow extent water solubl indic extent adsorpt ionis substanc preliminari rang find varieti correl publish group chemic apparatu liquid chromatograph fit puls free pump suitabl detect devic requir inject valv inject loop recommend commerci cyanopropyl chemic bound resin silica base hypersil zorbax cn guard column materi posit inject system analyt column column supplier vari consider separ effici guidanc capac factor reach log amp gt log koc log amp gt log koc methanol water mobil phase mobil phase mobil phase test recommend methanol water methanol citrat buffer ph hplc grade methanol distil water citrat buffer prepar elut solvent mixtur degass isocrat elut emploi methanol water mixtur organ solvent water mixtur ethanol water acetonitril water mixtur ionis compound buffer solut recommend stabilis ph care avoid salt precipit column deterior occur organ phase buffer mixtur addit ion pair reagent affect sorption properti stationari phase stationari phase irrevers reason mandatori experi addit carri separ column solut test refer substanc dissolv mobil phase perform test test condit temperatur measur record temperatur control column compart highli recommend guarante constant condit calibr estim run measur test substanc determin dead time determin dead time method section determin dead time mean homolog seri procedur proven yield reliabl standardis valu detail test method partit coeffici octanol water hplc method determin dead time inert substanc retain column techniqu base inject solut formamid urea sodium nitrat measur perform duplic determin retent time tr refer substanc select section inject mix standard determin retent time provid confirm retent time refer standard unaffect presenc refer standard calibr perform regular interv daili order account unexpect column perform practic calibr inject carri inject test substanc confirm retent time drift test substanc inject separ quantiti small avoid column overload retent time determin order increas confid measur duplic determin made valu log koc deriv individu measur fall rang log unit evalu capac factor calcul dead time retent time tr select refer substanc equat section log data refer substanc plot log koc valu batch equilibrium experi tabl appendix plot log test substanc determin log koc actual result show log koc test substanc calibr rang test repeat refer substanc data report report includ inform ident test refer substanc puriti pka valu relev descript equip oper condit type dimens analyt guard column mean detect mobil phase ratio compon ph temperatur rang measur dead time method determin quantiti test refer substanc introduc column retent time refer compound calibr detail fit regress line log log koc graph regress line averag retent data estim log koc test compound chromatogram refer lyman reehl rosenblatt ed handbook chemic properti estim method chap mcgraw hill york hodson william estim adsorpt coeffici koc soil hplc chemospher brigg theoret experiment relationship soil adsorpt octanol water partit coeffici water solubl bioconcentr factor parachor agric food chem pp chiou porter schmed partit equilibria nonion organ compound soil organ matter water environ sci technol pp gerstl mingelgrin sorption organ substanc soil sediment environm sci health pp chiou peter freed physic concept soil water equilibria nonion organ compound scienc pp karickhoff semi empir estim sorption hydrophob pollut natur sediment soil chemospher pp kördel henneck herrmann applic hplc screen method determin adsorpt coeffici sewag sludg chemospher pp mueller kördel comparison screen method estim adsorpt coeffici soil chemospher pp kördel stutt kotthoff hplc screen method determin adsorpt coeffici soil comparison stationari phase chemospher pp von oepen kördel klein sorption nonpolar polar compound soil process measur experi applic modifi oecd guidelin chemospher pp kördel kotthoff müller hplc screen method determin adsorpt coeffici soil result ring test chemospher pp appendix tabl comparison koc valu soil sewag sludg calcul valu hplc screen method kördel henneck herrmann applic hplc screen method determin adsorpt coeffici sewag sludg chemospher pp kördel henneck frank determin adsorpt coeffici organ substanc sewag sludg chemospher pp gt tabl gt tabl result laboratori inter comparison test particip laboratori perform improv valid hplc method kördel kotthoff müller hplc screen method determin adsorpt coeffici soil result ring test chemospher pp gt tabl gt tabl recommend refer substanc hplc screen method base soil adsorpt data gt tabl gt daphnia magna reproduct test method reproduct toxic test method replic oecd tg introduct primari object test assess effect chemic reproduct output daphnia magna definit unit parent anim femal daphnia present start test reproduct output object studi offspr young daphnia produc parent anim test lowest observ effect concentr loec lowest test concentr substanc observ statist signific effect reproduct parent mortal amp lt compar control state exposur period test concentr loec harm effect equal greater observ loec condit satisfi full explan loec noec select observ effect concentr noec test concentr immedi loec compar control statist signific effect amp lt state exposur period ecx concentr test substanc dissolv water result reduct reproduct daphnia magna state exposur period intrins rate increas measur popul growth integr reproduct output ag specif mortal steadi state popul grow popul posit shrink popul neg sustain ultim lead extinct limit detect lowest concentr detect quantifi limit determin lowest concentr measur quantit mortal anim record dead immobil swim observ movement appendag post abdomen second gentl agit test contain definit report refer principl test method young femal daphnia parent anim ag hour start test expos test substanc ad water rang concentr test durat dai end test total number live offspr produc parent anim aliv end test assess mean juvenil produc adult die test exclud calcul reproduct output parent anim express wai number live offspr produc anim dai dai offspr observ report addit total number juvenil produc parent aliv end test reproduct output anim expos test substanc compar control order determin lowest observ effect concentr loec observ effect concentr noec addit data analys regress model order estim concentr reduct reproduct output ec ec ec surviv parent anim time product brood report substanc relat effect paramet growth length possibl intrins rate increas examin inform test substanc result acut toxic test method part perform daphnia magna result select rang test concentr reproduct test water solubl vapour pressur test substanc reliabl analyt method quantif substanc test solut report recoveri effici limit determin inform test substanc establish test condit includ structur formula puriti substanc stabil light stabil condit test pka pow result test readi biodegrad method valid test test valid perform criteria met control mortal parent anim femal daphnia exce end test number live offspr produc parent anim surviv end test amp gt descript test method apparatu test vessel apparatu contact test solut made glass chemic inert materi test vessel glass beaker addit equip requir oxygen meter microelectrod suitabl equip measur dissolv oxygen low volum sampl adequ apparatu temperatur control ph meter equip determin hard water equip determin total organ carbon concentr toc water equip determin chemic oxygen demand cod adequ apparatu control light regim measur light intens test organ speci test daphnia magna strau daphnia speci provid meet valid criteria valid criterion relat reproduct output control relev daphnia speci speci daphnia identifi justifi prefer clone identifi genotyp research shown reproduct perform clone origin ircha franc consist meet valid criterion amp gt offspr parent anim surviv cultur condit method clone accept provid daphnia cultur shown meet valid criteria test start test anim hour brood progeni deriv healthi stock show sign stress high mortal presenc male ephippia delai product brood discolour anim stock anim maintain cultur condit light temperatur medium feed anim unit volum similar test daphnia cultur medium test routin daphnia cultur good practic includ pre test acclim period week gener avoid stress parent anim test medium recommend fulli defin medium test avoid addit seawe soil extract difficult characteris improv opportun standardis laboratori elendt media appendix found suitabl purpos media accept provid perform daphnia cultur shown meet valid criteria test media includ undefin addit addit inform provid test report composit regard carbon content contribut diet provid recommend total organ carbon toc chemic oxygen demand cod stock prepar organ addit determin estim result contribut toc cod test medium made recommend toc level medium addit alga mg test substanc metal import recognis properti test medium hard chelat capac bear toxic test substanc reason fulli defin medium desir present fulli defin media suitabl long term cultur daphnia magna elendt media chelat agent edta work shown quot appar toxic quot cadmium gener lower reproduct test perform media media edta recommend test substanc metal media chelat agent avoid metal substanc advis altern medium astm reconstitut hard fresh water edta ad seawe extract combin astm reconstitut hard fresh water seawe extract suitabl long term cultur test daphnia magna exert mild chelat action due organ compon ad seawe extract begin test dissolv oxygen concentr mg ph rang vari unit test hard mg caco recommend test level demonstr reproduct perform complianc valid criteria test solut test solut chosen concentr prepar dilut stock solut stock solut prefer prepar dissolv substanc test medium organ solvent dispers requir case order produc suitabl concentr stock solut effort made avoid materi exampl suitabl solvent aceton ethanol methanol dimethylformamid triethylen glycol exampl suitabl dispers cremophor rh methylcellulos hco case test substanc test solut exce limit solubl test medium solvent produc stock solut dose accur water recommend solvent concentr final test medium amp lt ml solvent list toxic increas water solubl substanc dispers assist accur dose dispers recommend concentr final test medium amp lt ml dispers list toxic increas water solubl substanc test design treatment alloc test vessel subsequ handl test vessel random fashion failur result bia constru concentr effect experiment unit handl treatment concentr order time relat effect oper fatigu error lead greater effect higher concentr test result affect initi environment condit test posit laboratori consider block test procedur condit exposur durat test durat dai load parent anim maintain individu test vessel ml medium vessel larger volum meet requir analyt procedur determin test substanc concentr pool replic chemic analysi allow volum greater ml ration daphnia increas ensur adequ food avail complianc valid criteria flow test altern design technic reason consid group anim larger test volum test design report number anim semi static test anim individu held test concentr anim individu held control seri flow test anim divid group anim test concentr shown suitabl smaller number test organ minimum anim concentr divid replic equal number anim replic daphnid recommend note test anim held group express reproduct output total number live offspr produc parent anim aliv end test parent anim die case reproduct output express quot total number live offspr produc parent present begin test quot feed semi static test feed prefer daili time week media deviat flow test report test diet parent anim prefer live algal cell chlorella sp selenastrum capricornutum pseudokirchneriella subcapitata scenedesmu subspicatu suppli diet base amount organ carbon provid parent anim research shown daphnia magna ration level mg daphnia dai suffici achiev requir number offspr meet test valid criteria ration suppli consist rate period test desir lower rate begin increas test account growth parent anim case ration remain recommend rang mg daphnia dai time surrog measur algal cell number light absorb feed requir ration level conveni measur carbon content time consum laboratori produc nomograph relat surrog measur carbon content algal cultur appendix advic nomograph product nomograph check annual frequent algal cultur condit chang light absorb found surrog carbon content cell number concentr algal suspens fed daphnia minimis volum algal cultur medium transfer test vessel concentr alga achiev centrifug resuspens distil water deionis water daphnia cultur medium light hour light intens exceed ìe temperatur temperatur test media rang test temperatur vari limit addit test vessel purpos temperatur monitor aerat test vessel aerat test test concentr test concentr arrang geometr seri separ factor prefer exceed number replic test concentr section justif provid fewer concentr substanc test solubl limit test medium set rang concentr born mind aim obtain loec noec lowest test concentr low fecund concentr significantli lower control case test repeat reduc lowest concentr ii aim obtain loec noec highest test concentr high fecund concentr significantli lower control case test repeat increas highest concentr iii ecx effect reproduct estim advis suffici concentr defin ecx level confid ec effect reproduct estim advis highest test concentr greater ec estim ec confid interv ec wide satisfactorili assess adequaci fit model iv rang test concentr prefer includ concentr statist signific effect adult surviv chang natur test simpli reproduct test combin reproduct mortal test requir complex statist analysi prior knowledg toxic test substanc acut test rang find studi select test concentr solvent dispers aid prepar test solut section final concentr test vessel greater ml test vessel control test medium control seri relev control seri solvent dispers run addit test seri solvent dispers concentr vessel test substanc number replic section gener run test coeffici variat number live offspr produc parent anim control amp lt report test design individu held anim test medium renew frequenc medium renew depend stabil test substanc time week preliminari stabil test section test substanc concentr stabl rang nomin fall measur initi concentr maximum renew period dai consider frequent medium renew flow test medium renew semi static test seri test vessel prepar parent anim transfer glass pipett suitabl diamet volum medium transfer daphnia minimis observ result observ made test record data sheet exampl appendic measur requir addit observ requir offspr offspr produc parent anim prefer remov count daili appear brood prevent consum food intend adult purpos method number live offspr count presenc abort egg dead offspr record mortal mortal parent anim record prefer daili time offspr count paramet method design princip assess effect reproduct effect suffici quantifi statist analysi growth measur highli desir provid inform subleth effect reproduct measur measur length parent anim bodi length exclud anal spine end test recommend paramet measur calcul includ time product brood subsequ brood number size brood anim number abort brood presenc male ephippia intrins rate popul increas frequenc analyt determin measur oxygen concentr temperatur hard ph valu measur week fresh media control highest test substanc concentr test concentr test substanc determin regular interv semi static test concentr test substanc expect remain nomin rang recommend minimum highest lowest test concentr analys freshli prepar time renew occas week test analys made sampl solut freshli prepar renew determin repeat weekli interv test concentr test substanc expect remain nomin analys test concentr freshli prepar renew test measur initi concentr test substanc nomin suffici evid provid show initi concentr repeat stabl rang initi concentr chemic determin reduc week test highest lowest test concentr case determin test substanc concentr prior renew perform replic vessel test concentr flow test similar sampl regim semi static test measur quot quot solut applic case advis increas number sampl occas week set measur ensur test concentr remain stabl type test flow rate diluent test substanc check daili evid concentr substanc test satisfactorili maintain nomin measur initi concentr test result base nomin measur initi valu deviat nomin measur initi concentr greater result express term time weigh appendix data report treatment result purpos test determin effect test substanc total number live offspr produc parent anim aliv end test total number offspr parent anim calcul test vessel replic replic parent anim di test turn male replic exclud analysi analysi base reduc number replic estim loec noec effect chemic reproduct output calcul reproduct output replic concentr pool residu standard deviat analysi varianc anova concentr compar control multipl comparison method dunnett william test check anova assumpt homogen varianc hold recommend graphic formal signific test suitabl altern run bartlett test assumpt hold consider transform data homogenis varianc prior perform anova carri weight anova size effect detect anova signific differ calcul report estim concentr reduct reproduct output ec suitabl curv logist curv fit data statist method squar curv parameteris ec standard error estim directli greatli eas calcul confid limit ec good reason prefer confid level side confid limit quot fit procedur prefer provid mean assess signific lack fit graphic divid residu sum squar quot lack fit quot quot pure error compon quot perform signific test lack fit treatment give high fecund greater varianc number juvenil produc treatment give low fecund consider weight observ valu reflect varianc treatment group background inform refer analysi data final ring test logist curv fit model suitabl model gt refer graphic gt total number juvenil parent anim aliv end test calcul vessel substanc concentr expect number juvenil ec popul slope paramet model adequ larg number situat test check made valid model suggest case hormesi model low concentr give enhanc effect effect concentr ec ec estim prefer parameteris model estim ec test report test report includ test substanc physic natur relev physicochem properti chemic identif data includ puriti test speci clone genet type supplier sourc cultur condit speci daphnia magna report justifi test condit test procedur semi static flow volum load number daphnia litr photoperiod light intens test design number replic number parent replic detail cultur medium addit organ materi includ composit sourc method prepar toc cod stock prepar estim result toc cod test medium detail inform feed includ amount mg daphnia dai schedul type food includ alga specif speci strain cultur condit method prepar stock solut frequenc renew solvent dispers concentr result result preliminari studi stabil test substanc nomin test concentr result analys determin concentr test substanc test vessel data sheet appendix recoveri effici method limit determin report water qualiti test vessel ph temperatur dissolv oxygen concentr toc cod hard applic data sheet appendix full record live offspr parent anim data sheet appendix number death parent anim dai occur data sheet appendix coeffici variat control fecund base total number live offspr parent anim aliv end test plot total number live offspr parent anim replic aliv end test concentr test substanc lowest observ effect concentr loec reproduct includ descript statist procedur indic size effect detect observ effect concentr noec reproduct loec noec mortal parent anim report ecx reproduct confid interv graph fit model calcul slope dose respons curv standard error observ biolog effect measur report biolog effect observ measur growth parent anim includ justif explan deviat test method refer oecd test guidelin programm report workshop daphnia magna pilot ring test sheffield univers uk march oecd environment health safeti public seri test assess report final ring test daphnia magna reproduct test pari baird barber bradlei soar calow compar studi genotyp sensit acut toxic stress clone daphnia magna strauss ecotoxicolog environment safeti pp elendt selenium defici crustacea ultrastructur approach antenn damag daphnia magna strau protoplasma pp epa method measur acut toxic effluent receiv water freshwat marin organ fourth ed epa weber ed usepa cincinnati ohio vigano suitabl commerci spring water standard medium cultur daphnia magna bull environ contam toxicol pp astm standard guid conduct acut toxic test fish macroinvertebr amphibian american societi test materi philadelphia pp baird soar girl barber bradlei calow long term mainten daphnia magna strau ecotoxicolog test problem prospect proceed st european confer ecotoxicolog copenhagen løkke tyle amp bro rasmussen ed pp parkhurst fort wright reproduc life cycl toxic test daphnia magna bull environ contam toxicol pp cowgil milazzo sensit cladoceran water qualiti variabl salin hard arch hydrobiol pp korshikov pseudokirchneriella subcapitata hindak biologic prace sim watson holm standard daphnia juvenil product test environment toxicolog chemistri pp sim measur growth phytoplankton relationship total organ carbon commonli paramet algal growth arch hydrobiol pp dunnett multipl comparison procedur compar treatment control amer statist assoc pp dunnett tabl multipl comparison control biometr pp william test differ treatment mean dose level compar dose control biometr pp william comparison dose level dose control biometr pp draper smith appli regress analysi edit wilei brain cousen equat describ dose respons stimul growth low dose weed research pp wilson bossert primer popul biologi sinauer associ publish pool introduct quantit ecolog mcgraw hill seri popul biologi york pp meyer ingersol mcdonald boyc estim uncertainti popul growth rate jackknif bootstrap techniqu ecolog pp appendix prepar fulli defin elendt media acclim elendt media laboratori experienc difficulti directli transfer daphnia media success achiev gradual acclim move medium elendt elendt elendt acclim period long month prepar trace element gt tabl gt media gt tabl gt combin vitamin stock store frozen small aliquot vitamin ad media shortli note avoid precipit salt prepar complet media add aliquot stock solut ml deionis water fill litr public medium found elendt selenium defici crustacea ultrastructur approach antenn damag daphnia magna strau protoplasma pp appendix total organ carbon toc analysi product nomograph toc content algal feed recognis carbon content algal feed measur directli correl nomograph surrog measur algal cell number light absorb toc measur high temperatur oxid uv persulph method instrument determin total organ carbon total oxygen demand relat determinand hmso high holborn london wc hb nomograph product alga separ growth medium centrifug resuspens distil water measur surrog paramet toc concentr sampl triplic distil water blank analys toc concentr deduct algal sampl toc concentr nomograph linear requir rang carbon concentr exampl shown nb convers essenti laboratori prepar nomograph gt pic file quot en tif quot gt gt pic file quot en tif quot gt gt pic file quot en tif quot gt appendix data sheet record medium renew physic chemic monitor data feed daphnia reproduct adult mortal gt pic file quot en tif quot gt appendix data sheet record result chemic analysi measur concentr gt pic file quot en tif quot gt measur concentr percentag nomin gt pic file quot en tif quot gt appendix calcul time weight time weight concentr test substanc declin period medium renew concentr chosen repres rang concentr experienc parent daphnia select base biolog consider statist reproduct thought affect peak concentr experienc maximum concentr accumul longer term effect toxic substanc consid import averag concentr relev case averag time weight concentr take account variat instantan concentr time figur time weight gt pic file quot en tif quot gt figur show simplifi test last dai medium renew dai thin zig zag line repres concentr point time fall concentr assum follow exponenti decai process plot point repres observ concentr measur start end renew period thick solid line posit time weight time weight calcul area time weight equal area concentr curv calcul illustr tabl tabl calcul time weight gt tabl gt quot dai quot number dai renew period quot conc quot measur concentr start renew period quot conc quot measur concentr end renew period quot ln conc quot natur logarithm conc quot ln conc quot natur logarithm conc quot area quot area exponenti curv renew period calcul gt refer graphic gt time weight quot tw quot quot total area quot divid quot total dai quot daphnia reproduct test tabl extend cover dai clear observ start end renew period confirm decai process fact exponenti curv result calcul quot area quot exponenti decai process implaus curv absenc inform work caution requir chemic analysi fail find substanc end renew period estim quickli substanc disappear solut imposs obtain realist area curv imposs obtain reason time weight oecd pari test guidelin fish earli life stage toxic test oecd pari test guidelin fish earli life stage toxic test gt refer graphic gt plot concentr test substanc aqueou phase caqad versu time estim achiev equilibrium plateau fig appendix dt degrad time test substanc annex annex vi gener classif label requir danger substanc prepar content gt tabl gt gener introduct object classif identifi physico chemic toxicolog ecotoxicolog properti substanc prepar constitut risk normal handl identifi hazard properti substanc prepar label hazard order protect user gener public environ annex set gener principl govern classif label substanc prepar refer articl direct articl direct ec relev direct danger prepar address concern manufactur import nation author method classifi label danger substanc prepar requir direct direct ec intend provid primari mean gener public person work essenti inform danger substanc prepar label draw attent person handl substanc prepar inher danger materi label serv draw attent comprehens product inform safeti form label take account potenti hazard face normal handl danger substanc prepar form market necessarili form final dilut sever hazard highlight symbol hazard aris danger properti standard risk phrase safeti phrase give advic precaut case substanc inform complet substanc internation recognis chemic nomenclatur prefer european inventori exist commerci chemic substanc einec european list notifi chemic substanc elinc ec number address telephon number person establish commun respons place substanc market case prepar inform accord articl direct ec complet trade design prepar chemic substanc substanc present prepar full address telephon number person establish commun respons place prepar market articl requir manufactur distributor import danger substanc einec introduc annex oblig carri investig make awar relev access data exist properti substanc basi inform packag provision label substanc rule laid articl criteria annex data requir classif label substanc data requir classif label obtain substanc inform annex vii requir data classif label quot base set quot classif label review inform annex viii substanc refer section data requir classif label obtain number sourc result previou test inform requir intern rule transport danger substanc inform refer work literatur inform deriv practic experi result valid structur activ relationship expert judgement account prepar data requir classif label obtain concern physicochem data applic method annex appli prepar cover direct eec internation recognis method accept accord provis annex ii iii direct eec articl direct ec gaseou prepar calcul method flammabl oxidis properti gaseou prepar organ peroxid calcul method oxidis properti concern data health effect applic method annex case plant protect product internation recognis method accept accord provis annex ii iii direct eec articl direct ec applic convent method refer articl annex ii part direct ec case applic rule concern evalu carcinogen mutagen reproduct toxic properti applic convent method refer articl annex ii part direct ec concern data ecotoxicolog properti aquat toxic applic method annex subject condit refer annex iii part direct ec case plant protect product internation recognis method accept accord provis annex ii iii direct eec articl direct ec applic convent method refer articl annex iii part direct ec ii evalu potenti actual bioaccumul determin log pow bcf evalu degrad applic convent method refer articl annex iii part direct ec iii danger ozon layer applic convent method refer articl annex iii part direct ec note perform anim test perform anim test establish experiment data subject provis direct eec protect anim experiment purpos note physicochem properti organ peroxid organ peroxid prepar data deriv calcul method set section gaseou prepar calcul method flammabl oxidis properti section applic guid criteria classif cover physicochem toxicolog ecotoxicolog properti substanc prepar classif substanc prepar made section basi criteria section substanc section annex type hazard consid instanc classif impli section choic symbol risk phrase made basi classif order ensur specif natur potenti danger identifi classif express label notwithstand criteria substanc prepar form aerosol subject provis direct eec amend adapt technic progress definit quot substanc quot mean chemic element compound natur state obtain product process includ addit preserv stabil product impur deriv product process exclud solvent separ affect stabil substanc chang composit substanc chemic defin aceton complex mixtur constitu variabl composit aromat distil complex substanc individu constitu identifi quot prepar quot mean mixtur solut compos substanc applic guid criteria substanc guidanc criteria set annex directli applic data question obtain test method compar annex case data evalu compar test method emploi annex rule annex determin classif label case doubt applic relev criteria requir expert judgement case manufactur distributor import provision classifi label substanc basi assess evid compet person prejudic articl procedur concern inconsist propos submit entri provision classif annex propos made member state accompani scientif data section similar procedur inform identifi concern accuraci exist entri annex classif substanc impur addit individu constitu impur addit individu constitu substanc identifi account concentr greater equal limit substanc classifi toxic toxic carcinogen categori mutagen categori toxic reproduct categori danger environ assign symbol quot quot aquat environ danger ozon layer substanc classifi harm corros irrit sensitis carcinogen categori mutagen categori toxic reproduct categori danger environ assign symbol quot quot harm aquat organ long term advers effect lower valu annex except substanc list specif annex classif carri requir articl council direct ec case asbesto gener rule appli concentr limit fix annex substanc asbesto present classifi label principl articl direct applic guid criteria prepar guidanc criteria set annex directli applic data question obtain test method compar annex except criteria section convent method applic convent method applic relat criteria section except aquat toxic subject condit refer annex iii part direct ec prepar cover direct eec data classif label accept internation recognis method special provis section annex case data evalu compar test method emploi annex rule annex determin classif label health environment hazard assess appli convent method refer articl annex ii iii direct ec individu concentr limit set annex direct annex ii part annex iii part direct ec substanc substanc annex direct concentr limit case prepar mixtur gase classif respect health environment effect establish calcul method basi individu concentr limit annex direct limit annex basi criteria annex ii iii direct ec prepar substanc section constitu prepar label prepar conform provis articl principl set articl direct ec case inform label prepar substanc section insuffici enabl manufactur constitu prepar carri classif label prepar correctli case person establish commun respons place origin prepar substanc section market manufactur import distributor suppli justifi request data danger substanc present enabl correct classif label prepar data enabl person respons place prepar market compli requir direct ec classif basi physicochem properti introduct test method relat explos oxidis flammabl properti includ annex serv give specif mean gener definit articl criteria follow directli test method annex mention adequ inform demonstr practic physico chemic properti substanc prepar organ peroxid reveal test method annex substanc prepar classifi hazard present handl substanc prepar person criteria classif choic symbol indic danger choic risk phrase case prepar criteria refer articl direct ec consider explos substanc prepar classifi explos assign symbol quot quot indic danger quot explos quot accord result test annex substanc prepar explos market risk phrase obligatori basi risk explos shock friction fire sourc ignit substanc prepar set extrem risk explos shock friction fire sourc ignit substanc prepar sensit picric acid salt petn oxidis substanc prepar classifi oxidis assign symbol quot quot indic danger quot oxidis quot accord result test annex risk phrase obligatori basi test result subject fire organ peroxid flammabl properti contact combust materi contact combust materi fire oxidis substanc prepar includ inorgan peroxid fire enhanc risk fire contact combust materi explos mix combust materi substanc prepar includ inorgan peroxid explos mix combust materi chlorat remark peroxid explos properti organ peroxid prepar thereof form market classifi criteria section basi test carri accord method annex oxidis properti exist method annex appli organ peroxid substanc organ peroxid classifi explos classifi danger basi structur prepar classifi explos classifi calcul method base percentag activ oxygen shown section organ peroxid prepar thereof classifi explos classifi oxidis peroxid formul organ peroxid oxygen organ peroxid hydrogen peroxid extrem flammabl substanc prepar classifi extrem flammabl assign symbol quot quot indic danger quot extrem flammabl quot accord result test annex risk phrase assign accord criteria extrem flammabl liquid substanc prepar flash point lower boil point case boil rang initi boil point lower equal gaseou substanc prepar flammabl contact air ambient temperatur pressur highli flammabl substanc prepar classifi highli flammabl assign symbol quot quot indic danger quot highli flammabl quot accord result test annex risk phrase assign accord criteria highli flammabl solid substanc prepar readili catch fire contact sourc ignit continu burn consum remov sourc ignit liquid substanc prepar flash point extrem flammabl contact water liber extrem flammabl gase substanc prepar contact water damp air evolv extrem flammabl gase danger quantiti minimum rate litr kilogram hour spontan flammabl air substanc prepar hot final catch fire contact air ambient temperatur input energi flammabl substanc prepar classifi flammabl accord result test annex risk phrase assign accord criteria mention flammabl liquid substanc prepar flash point equal greater equal practic shown prepar flash point equal greater equal classifi flammabl prepar support combust long reason fear risk handl prepar person physico chemic properti addit risk phrase assign substanc prepar classifi virtu section section accord criteria base experi obtain compil annex explos dry explos substanc prepar put market solut wet form nitrocellulos nitrogen form sensit explos metal compound substanc prepar form sensit explos metal deriv picric acid styphnic acid heat explos thermal unstabl substanc prepar classifi explos perchlor acid amp gt explos contact air substanc prepar unstabl ambient temperatur acetylen fire reactiv substanc prepar fluorin sodium hydrosulphit react violent water substanc prepar react violent water acetyl chlorid alkali metal titanium tetrachlorid explos mix oxidis substanc substanc prepar react explos oxidis agent red phosphoru form flammabl explos vapour air mixtur prepar classifi flammabl volatil compon flammabl air form explos peroxid substanc prepar form explos peroxid storag diethyl ether dioxan highli flammabl prepar classifi flammabl flammabl due loss flammabl volatil compon risk explos heat confin substanc prepar classifi explos accord section displai explos properti practic heat suffici confin substanc decompos explos heat steel drum show effect heat strong contain addit risk phrase section classif basi toxicolog properti introduct classif concern acut long term effect substanc prepar result singl instanc exposur repeat prolong exposur demonstr epidemiolog studi scientif valid case studi annex statist back experi assess data poison inform unit occup diseas toxicolog effect man differ suggest applic method outlin section annex substanc prepar classifi effect man test man discourag negat posit anim data direct eec seek protect anim experiment scientif purpos endpoint valid vitro test method annex direct test classif substanc made basi experiment data accord criteria account magnitud effect acut toxic lethal irrevers effect singl exposur criteria section subacut subchron chronic toxic criteria section corros irrit effect criteria section sensitis effect criteria section specif effect health carcinogen mutagen reproduct toxic criteria section prepar classif relat danger health carri basi convent method refer articl annex ii direct ec absenc experiment data case classif base individu concentr limit annex direct annex ii part direct ec substanc substanc annex direct concentr limit experiment data criteria section exclud carcinogen mutagen toxic reproduct properti refer evalu convent method refer articl annex ii part direct ec note prejudic requir direct eec scientif demonstr person respons place prepar market toxicolog properti prepar correctli determin method outlin paragraph basi exist test result anim method outlin paragraph provid justifi specif authoris articl direct eec whichev method evalu danger prepar danger effect health defin annex ii part direct ec consider classif establish experiment result obtain anim test result valid man test reflect risk man acut oral toxic substanc prepar market establish method permit assess ld determin discrimin dose fix dose method determin rang exposur lethal expect acut toxic class method discrimin dose dose evid toxic mortal dosag level annex mg kg bodi weight concept quot evid toxic quot design toxic effect exposur substanc test sever exposur highest fix dose lead mortal result test dose fix dose method surviv surviv evid toxic surviv evid toxic criteria section final test result shown mg kg dose primarili obtain inform toxic effect substanc low acut toxic classifi basi acut toxic fix dose method requir case test higher lower dose test relev dose level refer evalu tabl test method bi rang exposur lethal expect deriv observ absenc presenc substanc relat mortal acut toxic class method initi test fix start dose mg kg bodi weight acut toxic class method requir case test higher lower dose test relev dose level refer test procedur flow chart test method ter annex criteria classif choic symbol indic danger choic risk phrase toxic substanc prepar classifi toxic assign symbol quot quot indic danger quot toxic quot accord criteria risk phrase assign accord criteria toxic swallow acut toxic result ld oral rat amp lt mg kg surviv mg kg oral rat fix dose procedur high mortal dose amp lt mg kg oral rat acut toxic class method test result interpret flow chart appendix test method ter annex toxic contact skin acut toxic result ld dermal rat rabbit amp lt mg kg toxic inhal acut toxic result lc inhal rat aerosol particul amp lt mg litr lc inhal rat gase vapour amp lt mg litr danger irrevers effect strong evid irrevers damag effect refer section caus singl exposur rout gener mention dose rang order rout administr exposur combin toxic substanc prepar classifi toxic assign symbol quot quot indic danger quot toxic quot accord criteria risk phrase assign accord criteria toxic swallow acut toxic result ld oral rat amp lt ld amp lt mg kg discrimin dose oral rat mg kg surviv evid toxic high mortal dose rang amp gt amp lt mg kg oral rat acut toxic class method test result interpret flow chart appendix test method ter annex toxic contact skin acut toxic result ld dermal rat rabbit amp lt ld amp lt mg kg toxic inhal acut toxic result lc inhal rat aerosol particul amp lt lc amp lt mg litr lc inhal rat gase vapour amp lt lc amp lt mg litr danger irrevers effect strong evid irrevers damag effect refer section caus singl exposur rout gener mention dose rang order rout administr exposur combin danger damag health prolong exposur damag clear function disturb morpholog chang toxicolog signific caus repeat prolong exposur rout substanc prepar classifi toxic effect observ level order magnitud lower fold set section order rout administr exposur combin harm substanc prepar classifi harm assign symbol quot xn quot indic danger quot harm quot accord criteria risk phrase assign accord criteria harm swallow acut toxic result ld oral rat amp lt ld amp lt mg kg discrimin dose oral rat mg kg surviv evid toxic surviv mg kg rat oral fix dose procedur refer evalu tabl test method bi annex high mortal dose rang amp gt amp lt mg kg oral rat acut toxic class method test result interpret flow chart appendix test method ter annex harm contact skin acut toxic result ld dermal rat rabbit amp lt ld amp lt mg kg harm inhal acut toxic result lc inhal rat aerosol particul amp lt lc amp lt mg litr lc inhal rat gase vapour amp lt lc amp lt mg litr harm lung damag swallow liquid substanc prepar present aspir hazard human low viscos substanc prepar aliphat alicycl aromat hydrocarbon total concentr equal greater flow time sec mm iso cup iso april juli edit relat quot paint varnish determin flow time flow cup quot kinemat viscos measur calibr glass capillari viscomet accord iso sec iso edit relat quot petroleum product transpar opaqu liquid determin kinemat viscos calcul dynam viscos quot iso edit relat quot glass capillari kinemat viscomet specif oper instruct quot kinemat viscos deriv measur rotat viscometri accord iso sec iso edit relat quot plastic polym resin liquid state emuls dispers determin viscos rotat viscomet defin shear rate quot note substanc prepar meet criteria classifi surfac tension greater mn measur du noui tensiomet test method shown annex part substanc prepar base practic experi human risk irrevers effect strong evid irrevers damag effect refer section caus singl exposur rout gener mention dose rang order rout administr exposur combin danger damag health prolong exposur damag clear function disturb morpholog chang toxicolog signific caus repeat prolong exposur rout substanc prepar classifi harm effect observ level order oral rat amp lt mg kg bodyweight dai dermal rat rabbit amp lt mg kg bodyweight dai inhal rat amp lt mg dai guid valu appli directli sever lesion observ subchron dai toxic test interpret result subacut dai toxic test figur increas approxim threefold chronic year toxic test evalu case case basi result studi durat studi longest durat order rout administr exposur combin comment volatil substanc substanc high satur vapour concentr evid effect give concern substanc classifi criteria health effect guid cover section evid substanc present risk normal handl classif case case basi annex comment risk phrase refer specif rang biolog effect term applic risk phrase damag health consid includ death clear function disturb morpholog toxicolog signific import irrevers import specif sever singl organ biolog system generalis sever natur involv organ sever gener health statu assess evid type effect refer made guidelin evid indic appli substanc relat death major function central peripher nervou system includ sight hear sens smell assess clinic observ method electrophysiolog ii major function organ system lung consist clinic biochemistri haematolog urinalysi paramet sever organ dysfunct haematolog disturb consid import evid suggest due decreas bone marrow product blood cell sever organ damag note microscop examin autopsi widespread sever necrosi fibrosi granuloma format vital organ regen capac liver ii sever morpholog potenti revers clear evid mark organ dysfunct sever fatti chang liver sever acut tubular nephrosi kidnei ulcer gastriti iii evid appreci cell death vital organ incap regener fibrosi myocardium dy back nerv stem cell popul aplasia hypoplasia bone marrow evid obtain anim experi data deriv practic experi special attent exposur level evid indic appli risk phrase restrict quot damag health prolong exposur quot number substanc relat effect observ human anim justifi effect relev attempt determin effect level chemic substanc exampl document justifi classif irrespect statist signific includ clinic observ bodyweight gain food consumpt water intak toxicolog import quot damag quot small clinic biochemistri haematolog urinalysi paramet doubt minim toxicolog import organ weight evid organ dysfunct adapt respons macrophag migrat lung liver hypertrophi enzym induct hyperplast respons irrit local effect skin produc repeat dermal applic substanc appropri classifi quot irrit skin quot speci specif mechan toxic specif metabol pathwai demonstr corros substanc prepar classifi corros assign symbol quot quot indic danger quot corros quot accord criteria substanc prepar consid corros appli healthi intact anim skin produc full thick destruct skin tissu anim test skin irrit cite annex equival method classif base result valid vitro test cite annex skin corros rat skin transcutan electr resist assai human skin model assai substanc prepar consid corros result predict strongli acid alkalin reaction ph greater extrem ph basi classif acid alkali reserv consider consider alkali acid reserv suggest substanc prepar corros test carri confirm prefer valid vitro test consider acid alkali reserv exoner substanc prepar classif corros risk phrase assign accord criteria sever burn appli healthi intact anim skin full thick destruct skin tissu occur result minut exposur result predict burn appli healthi intact anim skin full thick destruct skin tissu occur result hour exposur result predict organ hydroperoxid evid contrari note classif base result valid vitro test appli capac test method discrimin classif base consider extrem ph appli irrit substanc prepar classifi irrit assign symbol quot xi quot indic danger quot irrit quot accord criteria inflamm skin risk phrase assign accord criteria irrit skin substanc prepar signific inflamm skin persist hour exposur period hour determin rabbit cutan irrit test method cite annex inflamm skin signific score erythema eschar format oedema format calcul anim test case annex test complet anim erythema eschar format oedema format equival calcul anim separ observ anim case score read time hour effect calcul respect valu inflamm skin signific persist anim end observ time effect hyperplasia scale discolor fissur scab alopecia account relev data acut anim studi comment section consid signific effect compar substanc prepar signific inflamm skin base practic observ human prolong repeat contact organ peroxid evid contrari paresthesia paresthesia caus human skin contact pyrethroid pesticid regard irrit effect justifi classif xi phrase appli substanc effect ocular lesion risk phrase assign accord criteria irrit ey substanc prepar appli ey anim signific ocular lesion occur hour exposur persist hour ocular lesion signific score ey irrit test cite annex valu cornea opac equal greater iri lesion equal greater greater red conjunctiva equal greater oedema conjunctiva chemosi equal greater case annex test complet anim lesion anim equival valu iri lesion equal greater red conjunctiva equal greater case score read time hour effect calcul respect valu substanc prepar signific ocular lesion base practic experi human organ peroxid evid contrari risk damag ey substanc prepar appli ey anim sever ocular lesion occur hour exposur persist hour ocular lesion sever mean score ey irrit test annex valu cornea opac equal greater iri lesion greater case test complet anim lesion anim valu cornea opac equal greater iri lesion equal case score read time hour effect calcul respect valu ocular lesion sever present end observ time ocular lesion sever substanc prepar irrevers colour ey substanc prepar sever ocular lesion base practic experi human note substanc prepar classifi corros assign risk sever damag ey consid implicit includ label respiratori system irrit risk phrase assign accord criteria irrit respiratori system substanc prepar irrit respiratori system base practic observ human posit result anim test comment interpret practic observ human care distinguish effect lead classif section lead classif condit lead classif revers limit upper airwai posit result anim test includ data obtain gener toxic test includ histopatholog data respiratori system data measur experiment bradypnea assess airwai irrit sensitis sensitis inhal substanc prepar classifi sensitis assign symbol quot xn quot indic danger quot harm quot risk phrase accord criteria sensitis inhal evid substanc prepar induc specif respiratori hypersensit posit result anim test substanc isocyan evid specif isocyan respiratori hypersensit comment human evid evid substanc prepar induc specif respiratori hypersensit base human experi context hypersensit asthma hypersensit reaction rhiniti alveol consid condit clinic charact allerg reaction immunolog mechan demonstr evid human exposur decis classif account addit evid case size popul expos extent exposur evid refer clinic histori data lung function test relat exposur substanc confirm support evid includ chemic structur relat substanc respiratori hypersensit vivo immunolog test skin prick test vitro immunolog test serolog analysi studi indic specif immunolog mechan action repeat low level irrit pharmacolog mediat effect data posit bronchial challeng test substanc conduct accept guidelin determin specif hypersensit reaction clinic histori includ medic occup histori determin relationship exposur specif substanc prepar develop respiratori hypersensit relev inform includ aggrav factor home workplac onset progress diseas famili histori medic histori patient question medic histori includ note allerg airwai disord childhood smoke histori result posit bronchial challeng test consid provid suffici evid classif recognis practic examin list carri substanc elicit symptom asthma irrit peopl bronchial hyperreact assign anim studi data test indic potenti substanc prepar sensitis inhal human includ ig measur mice specif pulmonari respons guinea pig sensitis skin contact substanc prepar classifi sensitis assign symbol quot xi quot indic danger quot irrit quot risk phrase accord criteria sensitis skin contact practic experi show substanc prepar capabl induc sensitis skin contact substanti number person posit result anim test comment human evid evid practic experi suffici classifi substanc prepar posit data patch test dermatolog clinic epidemiolog studi show allerg contact dermat caus substanc prepar situat high proport expos exhibit characterist symptom look special concern number case small posit data experiment studi man suffici classifi substanc support evid isol episod allerg contact dermat epidemiolog studi chanc bia confound rule fulli reason confid support evid includ data anim test perform exist guidelin result meet criteria section anim studi suffici close limit consid signific data standard method structur activ relationship anim studi posit result anim test case adjuv type test method skin sensitis detail annex case adjuv type test method respons anim consid posit test method respons anim consid posit immunolog contact urticaria substanc prepar meet criteria addit immunolog contact urticaria case inform contact urticaria includ phrase safeti data sheet substanc prepar produc sign immunolog contact urticaria fulfil criteria consider classif recognis anim model identifi substanc immunolog contact urticaria classif base human evid similar skin sensitis toxicolog properti addit risk phrase assign accord criteria base experi obtain compil annex substanc prepar classifi virtu section contact water liber toxic ga substanc prepar contact water damp air evolv toxic toxic gase potenti danger amount aluminium phosphid phosphoru pentasulphid contact acid liber toxic ga substanc prepar react acid evolv toxic gase danger amount sodium hypochlorit barium polysulphid substanc member gener public mix manufactur suitabl contact acid liber toxic ga substanc prepar react acid evolv toxic gase danger amount salt hydrogen cyanid sodium azid substanc member gener public mix manufactur suitabl danger cumul effect substanc prepar accumul human bodi concern suffici justifi comment phrase section substanc annex part direct ec prepar harm breastf babi substanc prepar absorb women interfer lactat present includ metabolit breast milk amount suffici concern health breastf child comment phrase section substanc annex part direct ec prepar repeat exposur skin dryness crack substanc prepar concern result skin dryness flake crack meet criteria base practic observ normal handl relev evid predict effect skin section vapour drowsi dizzi volatil substanc prepar substanc clear symptom central nervou system depress inhal classifi respect acut inhal toxic evid data anim studi show clear sign cn depress narcot effect lethargi lack coordin includ loss right reflex ataxia concentr exposur time exceed mg ratio effect concentr amp lt satur vapour concentr svc amp lt practic experi human narcosi drowsi reduc alert loss reflex lack coordin vertigo document report compar exposur condit effect anim section supplementari risk phrase section classif basi specif effect human health introduct chapter set procedur classif substanc effect mention prepar section manufactur distributor import inform substanc classifi label accord criteria section provision label substanc accord criteria basi assess evid compet person manufactur distributor import submit document summaris relev inform member state substanc market relev inform context compris publish unpublish inform requir classif substanc question basi intrins properti categori laid articl accord criteria annex submit summari document includ bibliographi relev refer includ relev unpublish data manufactur distributor import data relev classif label substanc accord criteria section submit data member state substanc market obtain quickli harmonis classif commun procedur defin articl direct member state relev inform justifi classif substanc categori submit manufactur forward inform suggest classif label commiss commiss forward member state classif label propos receiv member state commiss inform receiv member state good reason suggest classif label inappropri carcinogen mutagen reproduct toxic effect concern notifi commiss thereof criteria classif indic danger choic risk phrase carcinogen substanc purpos classif label regard current state knowledg substanc divid categori categori substanc carcinogen man suffici evid establish causal associ human exposur substanc develop cancer categori substanc regard carcinogen man suffici evid provid strong presumpt human exposur substanc result develop cancer gener basi long term anim studi relev inform categori substanc concern man ow carcinogen effect respect inform adequ make satisfactori assess evid anim studi insuffici place substanc categori symbol specif risk phrase appli categori substanc classifi carcinogen categori assign symbol quot quot risk phrase cancer substanc prepar present carcinogen risk inhal dust vapour fume rout exposur swallow contact skin present carcinogen risk assign symbol quot quot risk phrase cancer inhal categori substanc classifi carcinogen categori assign symbol quot xn quot risk phrase limit evid carcinogen effect comment categoris carcinogen substanc place substanc categori basi epidemiolog data place categori base primarili anim experi classif categori carcinogen posit result anim speci clear posit evid speci support evid genotox data metabol biochem studi induct benign tumour structur relationship carcinogen data epidemiolog studi suggest associ categori compris subcategori substanc investig evid tumour induc effect insuffici classif categori addit experi expect yield relev inform respect classif substanc insuffici investig date inadequ rais concern man classif provision experi final decis made distinct categori argument list relev reduc signific experiment tumour induct view human exposur argument combin lead case classif categori tumour induc anim carcinogen effect high dose level exceed quot maxim toler dose quot maxim toler dose characteris toxic effect reduc lifespan physic retard weight gain appear tumour high dose level organ speci suscept high spontan tumour format appear tumour site applic sensit test system applic local activ compound target relev man lack genotox short term test vivo vitro exist secondari mechan action implic practic threshold dose level hormon effect target organ mechan physiolog regul chronic stimul cell prolifer exist speci specif mechan tumour format specif metabol pathwai irrelev man distinct categori classif argument relev exclud concern man substanc classifi categori mechan experiment tumour format identifi good evid process extrapol man tumour data liver tumour sensit strain mice supplementari evid substanc classifi categori attent paid case tumour data occurr neoplasm site strain occur spontan high incid mutagen substanc purpos classif label regard current state knowledg substanc divid categori categori substanc mutagen man suffici evid establish causal associ human exposur substanc herit genet damag categori substanc regard mutagen man suffici evid provid strong presumpt human exposur substanc result develop herit genet damag gener basi anim studi relev inform categori substanc concern man ow mutagen effect evid mutagen studi insuffici place substanc categori symbol specif risk phrase appli categori substanc classifi mutagen categori assign symbol quot quot risk phrase herit genet damag categori substanc classifi mutagen categori assign symbol quot xn quot risk phrase risk irrevers effect comment categoris mutagen substanc definit term mutat perman chang amount structur genet materi organ result chang phenotyp characterist organ alter involv singl gene block gene chromosom effect involv singl gene consequ effect singl dna base point mutat larg includ delet gene effect chromosom involv structur numer mutat germ cell sexual reproduc organ transmit offspr mutagen agent rise enhanc occurr mutat note substanc classifi mutagen specif refer inherit genet damag type result lead classif chemic categori quot induct genet relev event somat cell quot gener regard alert carcinogen activ method develop mutagen test ongo process test standardis protocol evalu criteria present evalu mutagen data qualiti test perform degre valid test method consid categori place substanc categori posit evid human mutat epidemiolog studi need exampl substanc date recognis extrem difficult obtain reliabl inform studi incid mutat human popul increas frequenc categori place substanc categori posit result need assai show mutagen effect cellular interact relev mutagen germ cell mammal vivo mutagen effect somat cell mammal vivo combin clear evid substanc relev metabolit reach germ cell respect placement categori present method vivo germ cell mutagen assai specif locu mutat test herit transloc test domin lethal mutat test assai demonstr appear affect progeni defect develop embryo vivo assai show relev interact germ cell dna assai chromosom abnorm detect cytogenet analysi includ aneuploidi caus malsegreg chromosom test sister chromatid exchang sce test unschedul dna synthesi ud assai coval bind mutagen germ cell dna assai kind dna damag assai provid evid indirect natur posit result assai support posit result vivo somat cell mutagen assai mammal man categori prefer method vivo assai show mutagen effect somat cell mammal combin toxicokinet method methodolog capabl demonstr compound relev metabolit reach germ cell posit result host mediat assai demonstr unequivoc effect vitro assai consid support evid categori place substanc categori posit result need assai show mutagen effect cellular interact relev mutagen somat cell mammal vivo support posit result vitro mutagen assai effect somat cell vivo present method vivo somat cell mutagen assai bone marrow micronucleu test metaphas analysi metaphas analysi peripher lymphocyt mous coat colour spot test vivo somat cell dna interact assai test sce somat cell test ud somat cell assai coval bind mutagen somat cell dna assai dna damag alkalin elut somat cell substanc show posit result vitro mutagen assai classifi investig vivo assai strongli except case substanc show pronounc respons vitro assai relev vivo data show resembl mutagen carcinogen classif categori consid substanc toxic reproduct purpos classif label regard present state knowledg substanc divid categori categori substanc impair fertil human suffici evid establish causal relationship human exposur substanc impair fertil substanc development toxic human suffici evid establish causal relationship human exposur substanc subsequ development toxic effect progeni categori substanc regard impair fertil human suffici evid provid strong presumpt human exposur substanc result impair fertil basi clear evid anim studi impair fertil absenc toxic effect evid impair fertil occur dose level toxic effect secondari specif consequ toxic effect relev inform substanc regard development toxic human suffici evid provid strong presumpt human exposur substanc result development toxic gener basi clear result anim studi effect observ absenc sign mark matern toxic dose level toxic effect secondari specif consequ toxic effect relev inform categori substanc concern human fertil gener basi result anim studi provid suffici evid strong suspicion impair fertil absenc toxic effect evid impair fertil occur dose level toxic effect secondari specif consequ toxic effect evid insuffici place substanc categori relev inform substanc concern human ow development toxic effect gener basi result anim studi provid suffici evid strong suspicion development toxic absenc sign mark matern toxic dose level toxic effect secondari specif consequ toxic effect evid insuffici place substanc categori relev inform symbol specif risk phrase appli categori substanc impair fertil human substanc classifi toxic reproduct categori assign symbol quot quot risk phrase impair fertil substanc development toxic substanc classifi toxic reproduct categori assign symbol quot quot risk phrase harm unborn child categori substanc regard impair fertil human substanc classifi toxic reproduct categori assign symbol quot quot risk phrase impair fertil substanc regard development toxic human substanc classifi toxic reproduct categori assign symbol quot quot risk phrase harm unborn child categori substanc concern human fertil substanc classifi toxic reproduct categori assign symbol quot xn quot risk phrase risk impair fertil substanc concern human ow development toxic effect substanc classifi toxic reproduct categori assign symbol quot xn quot risk phrase risk harm unborn child comment categoris substanc toxic reproduct reproduct toxic includ impair male femal reproduct function capac induct inherit harm effect progeni classifi main head effect male femal fertil development toxic effect male femal fertil includ advers effect libido sexual behaviour aspect spermatogenesi oogenesi hormon activ physiolog respons interfer capac fertilis fertilis develop fertilis ovum includ implant development toxic widest sens includ effect interf normal develop birth includ effect induc manifest prenat manifest postnat includ embrytox fetotox effect reduc bodi weight growth development retard organ toxic death abort structur defect teratogen effect function defect peri postnat defect impair postnat mental physic develop includ normal pubert develop classif chemic toxic reproduct intend chemic intrins specif properti produc toxic effect chemic classifi toxic reproduct effect sole produc specif secondari consequ toxic effect chemic concern toxic reproduct exposur level produc sign toxic place compound categori effect fertil development toxic basi epidemiolog data place categori primarili basi anim data data vitro studi studi avian egg regard quot support evid quot exception lead classif absenc vivo data common type toxic effect substanc demonstr reproduct toxic expect threshold advers effect demonstr clear effect demonstr anim studi relev human doubt dose administ effect demonstr high dose mark toxicokinet differ exist rout administr inappropri similar reason classif categori classif warrant annex direct specifi limit test case substanc low toxic dose level mg kg oral produc evid effect toxic reproduct studi dose level consid data studi carri dose higher limit dose data evalu relev data normal circumst consid effect dose excess limit dose necessarili lead classif quot toxic reproduct quot effect fertil classif substanc categori impair fertil clear evid anim speci support evid mechan action site action chemic relationship anti fertil agent inform human lead conclus effect human studi speci relev support evid classif categori impair fertil occur specif accompani sever generalis toxic sever inanit classif categori made evid degre specif toxic reproduct system demonstr impair fertil anim studi due failur mate classif categori evid mechan action order interpret advers effect alter pattern hormon releas occur human development toxic classif categori clear evid advers effect conduct studi speci advers effect pregnanc postnat result secondari consequ matern toxic reduc food water intak matern stress lack matern care specif dietari defici poor anim husbandri intercurr infect import effect observ occur conduct studi dose level mark matern toxic rout exposur import inject irrit materi intraperiton result local damag uteru content result studi interpret caution lead classif classif categori base similar criteria categori experiment design defici make conclus convinc possibl effect due specif influenc generalis toxic exclud gener classif categori categori assign ad hoc basi effect record small incid spontan defect small proport common variant observ skelet examin small differ postnat development assess effect lactat substanc classifi toxic reproduct concern due effect lactat addit label criteria section purpos classif toxic effect offspr result exposur breast milk toxic effect result direct exposur children regard quot toxic reproduct quot effect result impair develop offspr substanc classifi toxic reproduct concern due toxic transfer babi period lactat label criteria section phrase substanc affect quantiti qualiti milk assign basi toxicokinet studi likelihood substanc present potenti toxic level breast milk basi result gener studi anim presenc advers effect offspr due transfer milk basi evid human indic risk babi lactat period substanc accumul bodi subsequ releas milk lactat label procedur classif prepar specif effect health prepar substanc classifi respect criteria laid classifi criteria refer annex ii part part direct ec concentr limit annex direct annex ii part direct ec substanc substanc consider annex concentr limit classif basi environment effect introduct primari object classifi substanc prepar danger environ alert user hazard substanc prepar present ecosystem present criteria refer aquat ecosystem recognis substanc prepar simultan altern affect ecosystem constitu rang soil microflora microfauna primat criteria set follow directli test method set annex mention test method requir quot base set quot refer annex vii limit inform deriv insuffici classif classif requir addit data deriv level annex viii equival studi classifi substanc subject review light data purpos classif label regard current state knowledg substanc prepar divid group acut long term effect aquat system acut long term effect aquat system classif substanc made basi experiment data acut aquat toxic degrad log pow bcf classif prepar carri basi convent method refer articl annex iii part direct ec case classif base individu concentr limit annex direct annex iii part direct ec substanc substanc annex direct concentr limit classif prepar made basi convent method determin acut aquat toxic case carri test prepar result test prepar modifi classif acut aquat toxic obtain applic convent method test chosen person respons place market ensur qualiti criteria test method part annex direct compli test carri group speci conform criteria annex alga daphnia fish highest hazard classif relat acut aquat toxic assign prepar test speci test result direct ec enter forc criteria classif indic danger choic risk phrase classif criteria substanc section appli prepar test accord aquat environ substanc classifi danger environ assign symbol quot quot indic danger assign risk phrase accord criteria toxic aquat organ long term advers effect aquat environ gt tabl gt substanc readili degrad log pow log octanol water partit coeffici amp gt experiment determin bcf amp lt toxic aquat organ gt tabl gt toxic aquat organ long term advers effect aquat environ gt tabl gt substanc readili degrad log pow amp gt experiment determin bcf amp lt substanc classifi danger environ accord criteria set risk phrase assign accord criteria harm aquat organ long term advers effect aquat environ gt tabl gt substanc readili degrad criterion appli exist addit scientif evid degrad toxic suffici provid adequ assur substanc degrad product constitut potenti long term delai danger aquat environ addit scientif evid base studi requir level annex viii studi equival includ proven potenti degrad rapidli aquat environ ii absenc chronic toxic effect concentr mg litr observ effect concentr greater mg litr determin prolong toxic studi fish daphnia harm aquat organ substanc fall criteria list chapter basi evid toxic present danger structur function aquat ecosystem long term advers effect aquat environ substanc fall criteria list chapter basi evid persist potenti accumul predict observ environment fate behaviour present long term delai danger structur function aquat ecosystem poorli water solubl substanc substanc solubl mg cover criterion readili degrad log pow amp gt experiment determin bcf amp lt criterion appli substanc exist addit scientif evid degrad toxic suffici provid adequ assur substanc degrad product constitut potenti long term delai danger aquat environ addit scientif evid base studi requir level annex viii studi equival includ proven potenti degrad rapidli aquat environ ii absenc chronic toxic effect solubl limit observ effect concentr greater solubl limit determin prolong toxic studi fish daphnia comment determin ic alga degrad demonstr case highli colour substanc algal growth inhibit sole result reduct light intens ic alga basi classif substanc consid readili degrad criteria hold true dai biodegrad studi level degrad achiev test base dissolv organ carbon test base oxygen deplet carbon dioxid gener theoret maxima level biodegrad achiev dai start degrad point time substanc degrad case cod bod data ratio bod cod greater equal convinc scientif evid demonstr substanc degrad biotic abiot aquat environ level amp gt dai period aquat environ substanc prepar classifi danger environ assign symbol quot quot indic danger assign risk phrase accord criteria toxic flora toxic fauna toxic soil organ toxic bee long term advers effect environ substanc prepar basi evid toxic persist potenti accumul predict observ environment fate behaviour present danger long term delai structur function natur ecosystem cover detail criteria elabor substanc prepar classifi danger environ assign symbol quot quot indic danger applic assign risk phrase accord criteria danger ozon layer substanc basi evid properti predict observ environment fate behaviour present danger structur function stratospher ozon layer includ substanc list annex council regul ec substanc deplet ozon layer oj subsequ amend prepar classifi basi convent method refer articl annex iii part direct ec choic safeti advic phrase introduct safeti advic phrase phrase assign danger substanc prepar accord gener criteria addit prepar safeti advic list annex direct ec mandatori manufactur mention chapter refer person respons place substanc prepar market safeti phrase substanc prepar lock applic toxic toxic corros substanc prepar criteria obligatori substanc prepar mention sold gener public reach children applic danger substanc prepar criteria obligatori danger substanc prepar sold gener public classifi danger environ cool place applic organ peroxid danger substanc prepar boil point amp lt criteria obligatori organ peroxid recommend danger substanc prepar boil point amp lt live quarter applic toxic toxic substanc prepar criteria limit toxic toxic substanc prepar desir supplement inhal risk substanc prepar store live quarter advic intend preclud proper substanc prepar live quarter content liquid manufactur applic spontan flammabl solid substanc prepar criteria limit special case sodium potassium white phosphor inert ga manufactur applic danger substanc prepar inert atmospher criteria limit special case organo metal compound contain tightli close applic organ peroxid substanc prepar give toxic toxic harm extrem flammabl gase substanc prepar contact moistur give extrem flammabl gase highli flammabl solid criteria obligatori organ peroxid recommend field applic mention contain dry applic substanc prepar react violent water substanc prepar contact water liber extrem flammabl gase substanc prepar contact water liber toxic toxic gase criteria limit field applic mention reinforc warn contain ventil place applic volatil substanc prepar give toxic toxic harm vapour extrem flammabl highli flammabl liquid extrem flammabl gase criteria recommend volatil substanc prepar give toxic toxic harm vapour recommend extrem flammabl highli flammabl liquid extrem flammabl gase contain seal applic substanc prepar give gase vapour liabl burst contain criteria limit special case mention food drink anim feedingstuff applic toxic toxic harm substanc prepar criteria recommend substanc prepar gener public incompat materi manufactur applic organ peroxid criteria obligatori limit organ peroxid except case incompat product risk heat applic substanc prepar decompos react spontan effect heat criteria limit special case monom assign risk phrase appli sourc ignit smoke applic extrem flammabl highli flammabl liquid extrem flammabl gase criteria recommend substanc prepar mention assign risk phrase appli combust materi applic substanc prepar form explos spontan flammabl mixtur combust materi criteria special case emphasis handl open contain care applic substanc prepar liabl produc overpressur contain substanc prepar form explos peroxid criteria limit abovement case risk damag ey substanc prepar gener public eat drink applic toxic toxic corros substanc prepar criteria limit special case arsen arsen compound fluoracet gener public smoke applic substanc prepar produc toxic product combust criteria limit special case halogen compound breath dust applic solid substanc prepar danger health criteria obligatori substanc prepar mention assign recommend substanc prepar mention suppli form inhal dust health hazard inhal breath ga fume vapour sprai word manufactur applic liquid gaseou substanc prepar danger health criteria obligatori substanc prepar mention assign obligatori substanc prepar intend sprai ascrib addit recommend draw attent user inhal risk mention risk phrase ascrib avoid contact skin applic substanc prepar danger health criteria obligatori substanc prepar ascrib ascrib recommend draw attent user skin contact risk mention risk phrase paresthesia ascrib emphasis risk phrase avoid contact ey applic substanc prepar danger health criteria recommend draw attent user ey contact risk mention risk phrase appli emphasis risk phrase recommend substanc ascrib gener public case contact ey rins immedi plenti water seek medic advic applic corros irrit substanc prepar criteria obligatori corros substanc prepar ascrib recommend irrit substanc prepar risk phrase ascrib immedi contamin cloth applic toxic toxic corros substanc prepar criteria obligatori toxic substanc prepar ascrib gener public recommend toxic substanc prepar ascrib industri safeti phrase ascrib recommend toxic substanc prepar ascrib corros substanc prepar gener public contact skin wash immedi plenti manufactur applic toxic toxic corros substanc prepar criteria obligatori toxic substanc prepar recommend substanc prepar mention water rins fluid recommend corros substanc prepar gener public empti drain applic extrem highli flammabl liquid immisc water toxic toxic substanc prepar substanc prepar danger environ criteria obligatori substanc prepar danger environ assign symbol quot quot gener public intend recommend substanc prepar mention gener public intend add water product applic substanc prepar react violent water criteria limit special case sulphur acid give clearest inform emphasis altern precautionari measur static discharg applic extrem highli flammabl substanc prepar criteria recommend substanc prepar industri absorb moistur virtual substanc prepar market gener public materi contain dispos safe applic danger substanc prepar criteria recommend substanc prepar special guidanc need ensur proper dispos wear suitabl protect cloth applic organ peroxid toxic toxic harm substanc prepar corros substanc prepar criteria obligatori toxic corros substanc prepar obligatori substanc prepar ascrib obligatori categori carcinogen mutagen substanc toxic reproduct effect produc sole inhal substanc prepar obligatori organ peroxid recommend toxic substanc prepar ld dermal unknown substanc prepar toxic skin contact recommend substanc prepar industri liabl damag health prolong exposur wear suitabl glove applic toxic toxic harm corros substanc prepar organ peroxid substanc prepar irrit skin caus sensitis skin contact criteria obligatori toxic corros substanc prepar obligatori substanc prepar ascrib obligatori categori carcinogen mutagen substanc toxic reproduct effect produc sole inhal substanc prepar obligatori organ peroxid recommend toxic substanc prepar ld dermal unknown substanc prepar harm skin contact recommend substanc prepar irrit skin case insuffici ventil wear suitabl respiratori equip applic toxic toxic substanc prepar criteria limit special case involv toxic toxic substanc prepar industri agricultur wear ey face protect applic organ peroxid corros substanc prepar includ irrit give rise risk damag ey toxic toxic substanc prepar criteria obligatori substanc prepar ascrib obligatori organ peroxid recommend draw attent user ey contact risk mention risk phrase ascrib limit except case toxic toxic substanc prepar risk splash easili absorb skin clean floor object contamin materi manufactur applic danger substanc prepar criteria limit danger substanc prepar water consid suitabl cleans agent absorpt powder materi dissolut solvent import health safeti reason provid warn label case fire explos breath fume applic danger substanc prepar combust give toxic toxic gase criteria limit special case fumig sprai wear suitabl respiratori equip word manufactur applic substanc prepar intend endang health safeti user proper precaut criteria limit special case case fire space precis type fire fight equip water increas risk add water applic extrem flammabl highli flammabl flammabl substanc prepar criteria obligatori substanc prepar contact water damp air evolv extrem flammabl gase recommend extrem flammabl highli flammabl flammabl substanc prepar immisc water case accid feel unwel seek medic advic immedi show label applic toxic substanc prepar toxic corros substanc prepar substanc prepar caus sensitis inhal criteria obligatori substanc prepar mention swallow seek medic advic immedi show contain label applic danger substanc prepar toxic toxic corros danger environ criteria obligatori danger substanc prepar mention gener public reason fear danger swallow children temperatur exceed manufactur applic substanc prepar unstabl temperatur criteria limit special case organ peroxid wet materi manufactur applic substanc prepar sensit spark friction impact allow dry criteria limit special case nitrocellulos origin contain applic substanc prepar sensit catalyt decomposit criteria substanc prepar sensit catalyt decomposit organ peroxid mix manufactur applic substanc prepar react product evolv toxic toxic gase organ peroxid criteria recommend substanc prepar mention gener public altern obligatori peroxid give violent reaction acceler promot ventil area applic substanc prepar intend produc vapour dust sprai fume mist give rise inhal risk fire explos risk criteria recommend import substanc prepar gener public recommend interior larg surfac area applic volatil toxic toxic harm substanc prepar criteria recommend damag health caus prolong exposur substanc prepar reason volatilis larg treat surfac home enclos place person congreg avoid exposur obtain special instruct applic substanc prepar carcinogen mutagen toxic reproduct criteria obligatori abovement substanc prepar phrase assign dispos materi contain hazard special wast collect point applic danger substanc prepar criteria recommend danger substanc prepar gener public special dispos requir contain avoid environment contamin applic substanc prepar assign symbol quot quot criteria limit substanc prepar gener public refer manufactur inform recoveri recycl applic danger substanc prepar criteria obligatori substanc prepar danger ozon layer recommend substanc prepar recoveri recycl recommend materi contain dispos hazard wast applic danger substanc prepar criteria recommend substanc prepar gener public assign avoid releas environ refer special instruct safeti data sheet applic substanc prepar danger environ criteria substanc prepar assign symbol quot quot recommend substanc prepar classifi danger environ cover swallow induc vomit seek medic advic immedi show contain label applic substanc prepar classifi harm accord criteria section applic substanc prepar market aerosol contain contain fit seal sprai attach section criteria obligatori substanc prepar mention sold gener public obligatori recommend substanc prepar mention industri obligatori case accid inhal remov casualti fresh air rest applic toxic toxic substanc prepar gase vapour particul volatil liquid substanc prepar caus respiratori sensitis criteria obligatori substanc prepar assign gener public result inhal swallow rins mouth water person consciou applic corros irrit substanc prepar criteria recommend substanc prepar gener public treatment suitabl label substanc prepar classifi label determin refer requir articl direct articl direct ec substanc prepar section explain label determin guidanc choos risk safeti phrase label inform prepar trade design substanc substanc prepar name substanc present prepar accord rule set articl direct ec full address telephon number person respons place substanc prepar market manufactur import distributor symbol indic danger phrase indic hazard phrase phrase indic safeti advic phrase substanc ec number addit substanc appear annex word quot ec label quot prepar offer sold gener public nomin quantiti content packag note prepar addit label requir set articl annex direct ec articl direct ec final choic risk safeti phrase final choic risk safeti phrase primarili govern give inform consider clariti impact label clariti mind inform express minimum number phrase case substanc irrit highli flammabl flammabl oxidis indic phrase phrase packag ml appli case volum harm substanc retail gener public prepar content packag exce ml classifi highli flammabl oxidis irrit except assign danger environ assign quot quot symbol phrase phrase classifi flammabl danger environ assign quot quot symbol phrase phrase prejudic articl direct eec direct ec indic quot toxic quot quot harm quot quot pollut quot quot ecolog quot statement indic substanc prepar danger lead underestim danger substanc prepar question label packag substanc prepar subject direct direct ec chemic displai label substanc list annex label show substanc design annex substanc list annex establish internation recognis chemic nomenclatur defin section prepar choic name displai label rule articl direct ec note subject annex direct ec sensitis substanc chosen accord section annex case concentr prepar intend perfum industri person respons place market identifi sensitis substanc judg primarili respons sensitis hazard case natur substanc chemic type quot essenti oil quot quot extract quot constitu essenti oil extract choic danger symbol design danger symbol word indic danger compli laid annex ii symbol print black orang yellow background substanc appear annex danger symbol indic danger shown annex danger substanc appear annex prepar danger symbol indic danger assign rule laid annex danger symbol assign substanc prepar oblig symbol quot quot make symbol quot quot quot quot quot quot option oblig symbol quot quot quot quot make symbol quot xn quot quot xi quot quot quot option oblig symbol quot quot make symbol quot xn quot quot xi quot option symbol quot xn quot assign symbol quot xi quot option choic risk phrase word phrase compli laid annex iii combin phrase annex iii applic substanc appear annex phrase shown annex substanc appear annex phrase select criteria prioriti case danger give rise health effect phrase categori danger illustr symbol label ii phrase categori danger illustr symbol virtu articl case danger aris physicochem properti phrase categori danger illustr symbol label case danger environ phrase classif categori quot danger environ quot label prepar phrase select criteria prioriti case danger give rise health effect phrase correspond categori danger illustr symbol case phrase adopt tabl annex ii part direct ec specif phrase constitu respons assign prepar danger categori label ii phrase correspond categori danger attribut constitu illustr symbol virtu articl direct ec case danger aris physicochem properti criteria applic risk phrase quot extrem flammabl quot quot highli flammabl quot repeat word indic danger symbol case danger environ phrase classif categori quot danger environ quot label ii phrase assign addit combin phrase phrase combin phrase gener rule prepar maximum phrase suffic describ risk purpos combin phrase list annex iii regard singl phrase prepar fall danger categori standard phrase cover princip hazard prepar case phrase safeti phrase word phrase compli laid annex iv combin phrase annex iv applic substanc appear annex phrase shown annex phrase shown manufactur import includ phrase substanc annex prepar manufactur includ phrase accord criteria chapter annex choic safeti phrase final choic safeti phrase regard risk phrase label intend substanc prepar gener rule maximum phrase suffic formul safeti advic purpos combin phrase list annex iv regard singl phrase case phrase dispos phrase clear dispos materi contain present danger human health environ advic safe dispos import substanc prepar sold gener public phrase superflu care select made phrase vice versa phrase correspond phrase label intend emphasis specif warn attent choic safeti phrase foreseen condit substanc prepar sprai aerosol effect phrase chosen intend view safeti phrase obligatori toxic toxic corros substanc prepar sold gener public safeti phrase obligatori danger substanc prepar classifi danger environ sold gener public phrase select strict criteria result redund ambigu unnecessari specif product packag phrase delet ec number substanc name label list european inventori exist commerci chemic substanc einec european list notifi substanc elinc einec elinc number substanc shown label requir appli prepar dimens label prepar gt tabl gt symbol cover tenth surfac area label cm label firmli affix surfac packag immedi prepar inform requir label stand background size space easili read special case substanc mobil ga cylind mobil ga cylind requir label consid satisfi agreement articl articl derog articl altern ga cylind water capac equal litr format dimens label follow prescript iso standard iso dp edit relat quot ga cylind precautionari label quot inform articl provid durabl inform disc label held captiv cylind ga contain intend propan butan liquefi petroleum ga lpg substanc classifi annex classifi accord articl present danger human health market close refil cylind refil cartridg scope en fuel gase releas combust en septemb edit relat quot refil metal ga cartridg liquefi petroleum gase valv portabl applianc construct inspect test mark quot cylind cartridg label symbol phrase flammabl inform effect human health requir label inform effect human health appear label transmit profession user person respons place substanc market format foreseen articl direct consum suffici inform transmit enabl measur health safeti foreseen articl direct eec amend direct eec metal massiv form substanc classifi annex classifi accord articl substanc classifi accord articl present danger human health inhal ingest contact skin aquat environ form market substanc requir label articl inform appear label transmit user person respons place metal market format foreseen articl substanc classifi substanc classifi harm basi aspir hazard label harm market aerosol contain contain fit seal sprai attach special case prepar gaseou prepar ga mixtur gaseou prepar consider evalu physico chemic properti evalu health hazard evalu environment hazard evalu physico chemic properti flammabl flammabl properti prepar determin accord articl direct ec method part annex direct prepar classifi result test carri respect criteria annex criteria label guid derog case gaseou prepar produc order small amount flammabl gaseou mixtur evalu calcul method express gaseou mixtur aifi anfn biii bpip ai bi molar fraction fi flammabl ga ii inert ga number flammabl gase number inert gase transform form ii inert gase express nitrogen equival coeffici ki equival content inflamm ga express ai ai kibi maximum content flammabl ga mixtur nitrogen composit flammabl air tci express obtain σi tci amp lt ga mixtur flammabl express greater prepar classifi extrem flammabl phrase assign coeffici equival ki valu coeffici equival ki inert gase nitrogen valu maximum content flammabl ga tci found tabl iso standard iso edit edit relat quot gase ga mixtur determin fire potenti oxidis abil select cylind valv outlet quot maximum content flammabl ga tci maximum content flammabl ga tci found tabl iso standard iso edit edit relat quot gase ga mixtur determin fire potenti oxidis abil select cylind valv outlet quot tci flammabl ga standard lower explos limit lel lel exist tci set volum remark express label gaseou prepar regard method replac experiment determin technic safeti paramet express inform mixtur oxidis gase prepar safe estim flammabl oxidis gase account express give reliabl result flammabl gase influenc flammabl concern consid halogen hydrocarbon oxidis properti fact annex direct method determin oxidis properti gaseou mixtur evalu properti realis estim method principl method comparison oxidis potenti gase mixtur oxidis potenti oxygen air concentr gase mixtur express vol consid ga mixtur oxid oxid air condit verifi ói xici amp gt xi concentr ga vol ci coeffici oxygen equival case prepar classifi oxidis phrase assign coeffici equival oxidis gase oxygen coeffici calcul determin oxidis capac gase mixtur respect oxidis capac oxygen air list iso standard iso edit edit relat quot gase ga mixtur determin fire potenti oxidis abil select cylind valv outlet quot gt tabl gt ci coeffici exist ga cite standard attribut coeffici label mobil ga contain requir label consid satisfi agreement articl direct ec derog articl ga contain water capac equal litr format dimens label follow prescript iso standard edit relat quot ga cylind precautionari label quot case label bear gener industri commerci prepar provid danger compon substanc prepar shown bodi ga cylind clear indel inform articl provid durabl inform disc label held captiv contain ga contain intend prepar stench propan butan liquefi petroleum ga lpg propan butan liquefi petroleum ga classifi annex prepar substanc classifi accord articl direct ec present danger human health market close refil cylind refil cartridg scope en fuel gase releas combust en septemb edit relat quot refil metal ga cartridg liquefi petroleum gase valv portabl applianc construct inspect test mark quot cylind cartridg label symbol phrase flammabl inform effect human health requir label inform effect human health appear label transmit profession user person respons place substanc market format foreseen articl direct ec consum suffici inform transmit enabl measur health safeti foreseen articl direct eec alloi prepar polym prepar elastom prepar classifi requir articl label requir articl direct ec prepar classifi accord articl present danger human health inhal ingest contact skin aquat environ form market prepar requir label articl annex inform appear label transmit profession user mean inform system format foreseen articl abovement direct prepar classifi prepar classifi harm basi aspir hazard label harm market aerosol contain contain fit seal sprai attach organ peroxid organ peroxid combin properti oxidis combust substanc molecul organ peroxid decompos oxidis part molecul react exotherm combust oxidis part oxidis properti exist method annex appli organ peroxid calcul method base presenc activ oxygen oxygen content organ peroxid prepar formula ni ci mi ni number peroxygen group molecul organ peroxid ci concentr mass organ peroxid mi molecular mass organ peroxid addit label requir prepar prepar addit label requir set articl annex direct ec articl direct ec young walker worth quot classif corros irrit skin prepar acid alkalin substanc test anim quot toxic vitro pp commiss statement regard section paragraph section commiss state envisag make procedur articl prepar consult advanc expert design member state special qualif respect carcinogen mutagen reproduct toxic consult place framework normal consult procedur nation expert framework exist committe case substanc includ annex reclassifi respect carcinogen mutagen effect effect toxic reproduct annex intermedi limit exposur provis point appli annex reduc test packag intermedi quantiti amp gt tonn annum definit prejudic commun legisl definit appli quot intermedi quot chemic substanc sole manufactur consum chemic process order transform chemic substanc quot emiss quot concern releas substanc system system breach guarante maximum level protect worker environ minimis emiss rigor contain process primari aim quot exposur quot concern substanc emit wider environ substanc potenti inhal contact skin member workforc emiss anticip occur rigor exposur control achiev techniqu note adopt precautionari principl physico chemic toxicolog ecotoxicolog properti test assum hazard quot integr exhaust ventil system quot exhaust ventil system close type combin lock enclosur hous contain order restrict chemic agent part close function unit process relat open small power extract air duct design suffici underpressur extract unit ensur gase vapour dust occur fulli captur carri back flow extract hazard substanc work area prevent mean hazard substanc prevent escap close function unit work area quot highli effect exhaust ventil quot exhaust ventil system open semi open type dimens chemic agent remain catchment area mean occurr chemic agent workplac atmospher practic exclud quot effect exhaust ventil system quot exhaust ventil system open semi open type dimens chemic agent remain catchment area occurr chemic agent workplac atmospher larg exclud proof adher limit furnish quot exhaust ventil system quot exhaust ventil system open semi open type dimens occurr chemic agent workplac atmospher exclud quot low emiss form quot expend packag hazard substanc enclos packag open packag introduc reaction system packag chang consist substanc form past granul powder form master batch mean hazard substanc surround plastic matrix prevent direct contact hazard substanc plastic matrix hazard substanc abras plastic matrix hazard substanc quot emiss free form quot master batch abras plastic matrix resist abras hazard substanc releas quot technic leakproof quot appli subunit leak discern test monitor check leakproof foam agent leak search indic equip perform system subsystem function element technic leakproof rate leakag amp lt mbar applic reduc test packag intermedi notifi request compet author grant permiss appli reduc test packag rtp rtp repres minimum data set design produc preliminari risk assess chemic intermedi market addit test result requir accord articl base outcom risk assess condit applic reduc test packag notifi demonstr satisfact compet author substanc notifi condit fulfil substanc sole manufactur consum chemic process monom exclud process substanc transform chemic molecul polym substanc restrict maximum number user site manufactur compani transport process note suppli intend progress user site condit rtp longer met dossier upgrad level suppli enterpris intermedi process directli notifi intermedi supplier substanc rigor contain technic mean lifecycl includ product transport purif clean mainten sampl analysi load unload equip vessel wast dispos purif storag gener process function element plant fill port empti equip close construct type assur leakproof close construct type integr exhaust ventil potenti exposur procedur control technolog minimis emiss result exposur case clean mainten work special procedur purg wash appli system open enter transport oper complianc requir council direct ec amend time time case accid wast gener purif clean mainten procedur environment exposur occur case procedur control technolog minimis emiss result exposur manag system exist identifi role individu organis packag substanc label annex vi direct eec addition sentenc quot caution substanc fulli test quot notifi oper system product stewardship monitor user maximum ensur complianc condit list technic dossier suppli reduc test packag notifi request rtp substanc suppli technic dossier compet author product user site statement notifi user accept condit list descript technic measur rigor contain substanc achiev includ procedur charg sampl transfer clean provid detail integr seal effici integr exhaust ventil mean achiev rigor contain process import inform need verifi assert made achiev control true criteria assess close system handl chemic agent detail section fulfil notifi submit exposur data base repres monitor data reliabl model calcul enabl compet author make decis accept rtp request detail descript process site involv product state product process wast discharg wast water liquid solid wast inciner clean mainten equip made detail assess emiss exposur man environ life cycl includ detail chemic reaction involv process wai residu dealt emiss lead exposur mean control suffici detail enabl compet author make decis accept statement calcul emiss rate eu technic guidanc document affect exposur man environ notifi advanc chang function element plant user site inform prescrib rtp annex vii test annex vapour pressur explos properti ignit temperatur oxidis properti granulometri acut toxic daphnia notifi includ relev inform enabl compet author make inform decis enabl proper control put place user intermedi process site supplementari physico chemic toxicolog inform inform environment behaviour data submit addition notifi review toxic ecotox data substanc close structur relationship notifi substanc relev data chronic reproduct toxic carcinogen summari data provid ident notifi produc user criteria assess close system handl chemic agent assess index assess plant assess index classifi handl substanc result process relat exposur potenti notifi examin plant plant unit order determin assess index individu function element assess system regard close assess function element correspond assess index function element involv close type assur leakproof equip integr exhaust ventil addit direct skin contact exclud collect exampl relev function element bold type function element partial open type highli effect exhaust ventil assess index normal type regard close mean rule case function element assign assess index safe adher limit perman basi assur function element close type leakproof assur partial open type effect exhaust ventil case function element assign assess indic adher limit valu assur function element partial open type open intend simpl exhaust ventil open simpl exhaust ventil open type partial open type natur ventil catalogu exampl tabl facilit classif function element function element includ collect exampl classifi mean conclus drawn analog plant plant unit classifi index function element receiv highest assess index check criterion requir adher process paramet laid perform check cite collect exampl inspect mainten applic reduc test packag compet author accept notifi applic rtp inform test studi set point requir technic dossier refer articl note quantiti tonn annum usual annex viib viic test requir appli tabl collect exampl gt tabl gt type construct technic specif leakproof close function element determin effect contain enabl compet author make decis rigor contain achiev essenti notifi includ detail aspect technic measur fulfil condit quot criteria assess close system handl chemic agent quot includ guidanc section tabl annex state notifi address type close function element descript provid technic measur deviat condit criteria fulli justif annex accord provis annex vii relat intermedi relev compet author authoris applic reduc test packag chemic substanc requir section reduc quantiti substanc market reach tonn year manufactur total quantiti substanc market reach tonn manufactur case relev compet author requir test studi laid point annex vii except perform addit relev compet author requir level test studi relat aquat organ quantiti substanc market reach tonn year manufactur total quantiti substanc market reach tonn manufactur case relev compet author requir level test studi relat reproduct toxic relev compet author decid classif substanc intermedi qualifi reduc test packag constitut good reason test studi relat reproduct toxic annex quantiti substanc market reach tonn year manufactur total quantiti substanc market reach tonn manufactur addit studi mention level requir relev compet author addit test requir addit test includ test laid level annex