council direct ec septemb establish annex vi direct eec place plant protect product market council european union regard treati establish european commun regard council direct eec juli place plant protect product market articl thereof regard propos commiss judgment court justic european commun june council direct ec juli establish annex vi direct eec annul annex vi direct eec lai uniform principl aim ensur member state decid author plant protect product appli requir articl direct equival manner high level protect human anim health environ sought direct lai detail principl evalu inform plant protect product suppli applic decis made author basi result evalu principl laid requir provid articl initi lai stage uniform principl chemic plant protect product remain uniform principl product micro organ laid accord procedur provid articl direct eec approach line direct eec articl thereof plant protect product high level protect groundwat satisfi condit laid author provid plant protect product author adequ demonstr accord condit laid author lead concentr activ substanc relev metabolit degrad reaction product groundwat exce lower limit valu groundwat refer direct appli plant protect product activ substanc market year notif direct eec mean product author grant adequ demonstr condit laid author expect concentr result exclus exce lower limit valu refer direct provis direct protect water includ provis relat monitor prejudic member state oblig direct concern direct eec eec eec review abovement direct progress adapt direct short implement period justifi light decis court justic european commun june provis groundwat review adopt direct articl annex vi direct eec establish set annex direct articl member state bring forc law regul administr provis compli direct octob member state adopt measur refer direct accompani refer occas offici public method make refer laid member state articl direct enter forc date public offici journal european commun articl direct address member state brussel septemb council presid boden oj direct amend commiss direct ec oj judgment june parliament council ecr oj council direct eec june qualiti requir surfac water intend abstract drink water member state oj direct amend direct eec oj council direct eec decemb protect groundwat pollut caus danger substanc oj direct amend direct eec oj council direct eec juli relat qualiti water intend human consumpt oj direct amend direct eec oj annex annex vi uniform principl evalu author plant protect product content introduct evalu gener principl specif principl efficaci absenc unaccept effect plant plant product impact vertebr control impact human anim health aris plant protect product aris residu influenc environ fate distribut environ impact target speci analyt method physic chemic properti decis make gener principl specif principl efficaci absenc unaccept effect plant plant product impact vertebr control impact human anim health aris plant protect product aris residu influenc environ fate distribut environ impact target speci analyt method physic chemic properti introduct principl develop annex aim ensur evalu decis regard author plant protect product provid chemic prepar result implement requir articl direct member state high level protect human anim health environ evalu applic grant author member state ensur dossier suppli accord requir annex iii latest time final evalu purpos decis make prejudic relev provis articl direct ensur data submit accept term quantiti qualiti consist reliabl suffici permit proper evalu dossier evalu relev justif submit applic suppli data account annex ii data activ substanc plant protect product submit purpos inclus activ substanc concern annex result evalu data prejudic relev provis articl direct consider relev technic scientif inform possess regard perform plant protect product potenti advers effect plant protect product compon residu specif principl evalu refer made annex ii data understood data refer point data inform provid suffici permit complet evalu propos applic evalu decis made propos take account justif provid benefit subsequ clarif member state reject applic data gap final evalu make reliabl decis propos process evalu decis make member state cooper applic order resolv question dossier quickli identifi earli stage addit studi proper evalu dossier amend propos condit plant protect product modifi natur composit order ensur full satisfact requir annex direct member state reason decis month receiv technic complet dossier technic complet dossier satisfi requir annex iii judgement made compet author member state evalu decis make process base scientif principl prefer recogn intern level eppo made benefit expert advic evalu gener principl regard current scientif technic knowledg member state evalu inform refer part point assess perform term efficaci phytotox plant protect product author sought identifi hazard aris assess signific make judgment risk human anim environ accord term articl direct inter alia specifi member state regard normal condit plant protect product consequ member state ensur evalu carri regard propos practic condit purpos dose manner frequenc time applic natur composit prepar member state account principl integr control evalu applic submit member state regard agricultur plant health environment includ climat condit area interpret result evalu member state consider element uncertainti inform obtain evalu order ensur chanc fail detect advers effect estim import reduc minimum decis make process examin identifi critic decis point item data uncertainti lead fals classif risk evalu made base data estim reflect realist condit plant protect product repeat evalu take account potenti uncertainti critic data rang condit occur result realist worst case approach determin initi evalu significantli specif principl section provid calcul model evalu plant protect product model make estim relev process involv take account realist paramet assumpt submit analysi refer point reliabl valid measur carri circumst relev model relev condit area metabolit degrad reaction product refer specif principl relev propos criterion consider specif principlesmemb state evalu data inform submit support applic prejudic gener principl section implement principl efficaci propos concern control protect organ member state evalu possibl organ harm agricultur plant health environment includ climat condit area propos propos concern effect control protect organ member state evalu signific damag loss inconveni occur agricultur plant health environment includ climat condit area propos plant protect product member state evalu efficaci data plant protect product provid annex iii regard degre control extent effect desir regard relev experiment condit choic crop cultivar agricultur environment includ climat condit presenc densiti harm organ develop stage crop organ amount plant protect product requir label amount adjuv ad frequenc time applic type applic equip member state evalu perform plant protect product rang agricultur plant health environment includ climat condit encount practic area propos level consist durat effect sought relat dose comparison suitabl refer product product untreat control ii relev effect yield reduct loss storag term quantiti qualiti comparison suitabl refer product product untreat control suitabl refer product exist member state evalu perform plant protect product determin consist defin benefit agricultur plant health environment includ climat condit area propos product label includ requir plant protect product plant protect product adjuv tank mix member state make evalu refer point relat inform suppli tank mix product label includ recommend plant protect product plant protect product adjuv tank mix member state evalu appropri mix condit absenc unaccept effect plant plant product member state evalu degre advers effect treat crop plant protect product propos condit comparison relev suitabl refer product product exist untreat control evalu consider inform efficaci data provid annex iii ii relev inform plant protect product natur prepar dose method applic number time applic iii relev inform activ substanc provid annex ii includ mode action vapour pressur volatil water solubl evalu includ natur frequenc level durat observ phytotox effect agricultur plant health environment includ climat condit affect ii differ main cultivar regard sensit phytotox effect iii part treat crop plant product phytotox effect observ iv advers impact yield treat crop plant product term quantiti qualiti advers impact treat plant plant product propag term viabil germin sprout root establish vi volatil product concern advers impact adjac crop data activ substanc signific metabolit degrad reaction product persist soil plant substanc signific quantiti plant protect product propos condit member state evalu degre advers effect subsequ crop evalu carri point product label includ requir plant protect product plant protect product adjuv tank mix evalu point carri relat inform suppli tank mix impact vertebr control propos plant protect product aim effect vertebr member state evalu mechan effect obtain observ effect behaviour health target anim intend effect kill target anim evalu time obtain death anim condit death occur evalu consider inform relev inform provid annex ii result evalu thereof includ toxicolog metabol studi ii relev inform plant protect product provid annex iii includ toxicolog studi efficaci data impact human anim health aris plant protect product member state evalu oper exposur activ substanc toxicolog relev compound plant protect product occur propos condit includ dose applic method climat condit prefer realist data exposur data suitabl valid calcul model evalu consider inform toxicolog metabol studi provid annex ii result evalu thereof includ accept oper exposur level aoel accept oper exposur level maximum amount activ substanc oper expos advers health effect aoel express milligram chemic kilogram bodi weight oper aoel base highest level advers effect observ test sensit relev anim speci data human ii relev inform activ substanc physic chemic properti iii toxicolog studi provid annex iii includ dermal absorpt studi iv relev inform provid annex iii composit prepar natur prepar size design type packag field natur crop target method applic includ handl load mix product exposur reduct measur recommend protect cloth recommend maximum applic rate minimum sprai applic volum state label number time applic evalu made type applic method applic equip propos plant protect product type size contain take account mix load oper applic plant protect product clean routin mainten applic equip member state examin inform relat natur characterist packag propos refer aspect type packag dimens capac size open type closur strength leakproof resist normal transport handl resist compat content member state examin natur characterist protect cloth equip propos refer aspect obtain suitabl eas wear take account physic stress climat condit member state evalu possibl exposur human bystand worker expos applic plant protect product anim activ substanc toxicolog relev compound plant protect product propos condit evalu consider inform toxicolog metabol studi activ substanc provid annex ii result evalu thereof includ accept oper exposur level ii toxicolog studi provid annex iii includ dermal absorpt studi iii relev inform plant protect product provid annex iii entri period wait period precaut protect human anim method applic sprai maximum applic rate maximum sprai applic volum composit prepar excess remain plant plant product treatment activ worker expos aris residu member state evalu specif inform toxicolog provid annex ii determin accept daili intak adi identif metabolit degrad reaction product treat plant plant product behaviour residu activ substanc metabolit time applic harvest case post harvest outload store plant product prior evalu residu level report trial product anim origin member state examin inform data propos good agricultur practic includ data applic provid annex iii propos pre harvest interv envisag withhold period storag period case post harvest natur prepar analyt method residu definit basi suitabl statist model member state evalu residu level observ report trial evalu made propos consider propos condit plant protect product ii specif inform residu treat plant plant product food feed provid annex iii distribut residu edibl edibl part iii specif inform residu treat plant plant product food feed provid annex ii result evalu thereof iv realist possibl extrapol data crop member state evalu residu level observ product anim origin take consider inform provid annex iii part point residu result member state estim potenti exposur consum diet relev wai exposur suitabl calcul model evalu account relev sourc inform author plant protect product activ substanc give rise residu member state relev estim exposur anim take account residu level observ treat plant plant product intend fed anim influenc environ fate distribut environ evalu fate distribut plant protect product environ member state regard aspect environ includ biota member state evalu possibl plant protect product reach soil propos condit possibl exist estim rate rout degrad soil mobil soil chang total concentr extract extract activ substanc relev metabolit degrad reaction product expect soil area envisag plant protect product propos condit evalu consider inform specif inform fate behaviour soil provid annex ii result evalu thereof ii relev inform activ substanc molecular weight solubl water octanol water partit coeffici vapour pressur volatil rate dissoci constant photodegrad rate ident breakdown product hydrolysi rate relat ph ident breakdown product iii inform plant protect product provid annex iii includ inform distribut dissip soil iv relev author plant protect product area propos activ substanc give rise residu member state evalu possibl plant protect product reach groundwat propos condit possibl exist estim suitabl calcul model valid commun level concentr activ substanc relev metabolit degrad reaction product expect groundwat area envisag plant protect product propos condit long valid commun calcul model member state base evalu result mobil persist soil studi provid annex ii iii evalu consider inform specif inform fate behaviour soil water provid annex ii result evalu thereof ii relev inform activ substanc molecular weight solubl water octanol water partit coeffici vapour pressur volatil rate hydrolysi rate relat ph ident breakdown product dissoci constant iii inform plant protect product provid annex iii includ inform distribut dissip soil water iv relev author plant protect product area envisag activ substanc give rise residu relev data dissip includ transform sorption satur zone vi relev data procedur drink water abstract treatment area envisag vii relev monitor data presenc absenc activ substanc relev metabolit degrad reaction product groundwat result previou plant protect product activ substanc give rise residu monitor data interpret consist scientif member state evalu possibl plant protect product reach surfac water propos condit possibl exist estim suitabl calcul model valid commun level short term long term predict concentr activ substanc metabolit degrad reaction product expect surfac water area envisag plant protect product propos condit valid commun calcul model member state base evalu result mobil persist soil studi inform run drift provid annex ii iii evalu consider inform specif inform fate behaviour soil water provid annex ii result evalu thereof ii relev inform activ substanc molecular weight solubl water octanol water partit coeffici vapour pressur volatil rate hydrolysi rate relat ph ident breakdown product dissoci constant iii relev inform plant protect product provid annex iii includ inform distribut dissip soil water iv rout exposur drift run oversprai discharg drain leach deposit atmospher relev author plant protect product area envisag activ substanc give rise residu vi relev data procedur drink water abstract treatment area envisag member state evalu possibl plant protect product dissip air propos condit possibl exist make estim suitabl valid calcul model concentr activ substanc relev metabolit degrad reaction product expect air plant protect product propos condit evalu consider inform specif inform fate behaviour soil water air provid annex ii result evalu thereof ii relev inform activ substanc vapour pressur solubl water hydrolysi rate relat ph ident breakdown product photochem degrad water air ident breakdown product octanol water partit coeffici iii relev inform plant protect product provid annex iii includ inform distribut dissip air member state evalu procedur destruct decontamin plant protect product packag impact target speci calcul toxic exposur ratio member state consider toxic sensit relev organ test member state evalu possibl exposur bird terrestri vertebr plant protect product propos condit possibl exist evalu extent short term long term risk expect organ includ reproduct plant protect product propos condit evalu consider inform specif inform relat toxicolog studi mammal effect bird target terrestri vertebr includ effect reproduct relev inform activ substanc provid annex ii result evalu thereof ii relev inform plant protect product provid annex iii includ inform effect bird target terrestri vertebr iii relev author plant protect product area envisag activ substanc give rise residu evalu includ fate distribut includ persist bioconcentr activ substanc relev metabolit breakdown reaction product part environ applic plant protect product ii estim exposur speci expos time applic period residu present take account relev rout exposur ingest formul product treat food predat invertebr feed vertebr prei contact oversprai treat veget iii calcul acut short term long term toxic exposur ratio toxic exposur ratio defin quotient ld lc observ effect concentr noec express activ substanc basi estim exposur express mg kg bodi weight member state evalu possibl exposur aquat organ plant protect product propos condit possibl exist evalu degre short term long term risk expect aquat organ plant protect product propos condit evalu consider inform specif inform relat effect aquat organ provid annex ii result evalu thereof ii relev inform activ substanc solubl water octanol water partit coeffici vapour pressur volatil rate koc biodegrad aquat system readi biodegrad photodegrad rate ident breakdown product hydrolysi rate relat ph ident breakdown product iii relev inform plant protect product provid annex iii effect aquat organ iv relev author plant protect product area envisag activ substanc give rise residu evalu includ fate distribut residu activ substanc relev metabolit breakdown reaction product water sediment fish ii calcul acut toxic exposur ratio fish daphnia ratio defin quotient acut lc ec predict short term environment concentr iii calcul algal growth inhibit exposur ratio alga ratio defin quotient ec predict short term environment concentr iv calcul long term toxic exposur ratio fish daphnia long term toxic exposur ratio defin quotient noec predict long term environment concentr relev bioconcentr fish exposur predat fish includ human vi plant protect product appli directli surfac water effect chang surfac water qualiti ph dissolv oxygen content member state evalu possibl exposur honeybe plant protect product propos condit possibl exist evalu short term long term risk expect honeybe plant protect product propos condit evalu consider inform specif inform toxic honeybe provid annex ii result evalu thereof ii relev inform activ substanc solubl water octanol water partit coeffici vapour pressur photodegrad rate ident breakdown product mode action insect growth regul activ iii relev inform plant protect product provid annex iii includ toxic honeybe iv relev author plant protect product area envisag activ substanc give rise residu evalu includ ratio maximum applic rate express gramm activ substanc hectar contact oral ld express ìg activ substanc bee hazard quotient persist residu relev treat plant ii relev effect honeybe larva honeybe behaviour coloni surviv develop plant protect product propos condit member state evalu possibl exposur benefici arthropod honeybe plant protect product propos condit possibl exist assess lethal subleth effect organ expect reduct activ plant protect product propos condit evalu consider inform specif inform toxic honeybe benefici arthropod provid annex ii result evalu thereof ii relev inform activ substanc solubl water octanol water partit coeffici vapour pressur photodegrad rate ident breakdown product mode action insect growth regul activ iii relev inform plant protect product provid annex iii effect benefici arthropod bee toxic honeybe data biolog primari screen maximum applic rate maximum number timet applic iv relev author plant protect product area envisag activ substanc give rise residu member state evalu possibl exposur earthworm target soil macro organ plant protect product propos condit possibl exist evalu degre short term long term risk expect organ plant protect product propos condit evalu consider inform specif inform relat toxic activ substanc earthworm target soil macro organ provid annex ii result evalu thereof ii relev inform activ substanc solubl water octanol water partit coeffici kd adsorpt vapour pressur hydrolysi rate relat ph ident breakdown product photodegrad rate ident breakdown product dt dt degrad soil iii relev inform plant protect product provid annex iii includ effect earthworm target soil macro organ iv relev author plant protect product area envisag activ substanc give rise residu evalu includ lethal subleth effect ii predict initi long term environment concentr iii calcul acut toxic exposur ratio defin quotient lc predict initi environment concentr long term toxic exposur ratio defin quotient noec predict long term environment concentr iv relev bioconcentr persist residu earthworm member state evalu carri part point exclud possibl plant protect product reach soil propos condit evalu impact microbi activ impact nitrogen carbon miner process soil plant protect product propos condit evalu consider inform relev inform activ substanc includ specif inform relat effect target soil micro organ provid annex ii result evalu thereof ii relev inform plant protect product provid annex iii includ effect target soil micro organ iii relev author plant protect product area propos activ substanc give rise residu iv inform biolog primari screen analyt method member state evalu analyt method propos post registr control monitor purpos determin formul analysi natur quantiti activ substanc plant protect product toxicolog ecotoxicolog environment signific impur formul evalu consider inform data analyt method provid annex ii result evalu thereof ii data analyt method provid annex iii specif linear propos method import interfer precis propos method intra laboratori repeat inter laboratori reproduc iii limit detect determin propos method impur residu analysi residu activ substanc metabolit breakdown reaction product result author plant protect product toxicolog ecotoxicolog environment signific evalu consider inform data analyt method provid annex ii result evalu thereof ii data analyt method provid annex iii specif propos method precis propos method intra laboratori repeat inter laboratori reproduc recoveri rate propos method concentr iii limit detect propos method iv limit determin propos method physic chemic properti member state evalu actual activ substanc content plant protect product stabil storag member state evalu physic chemic properti plant protect product suitabl fao specif exist physic chemic properti address specif suitabl fao specif exist relev physic chemic properti formul refer quot manual develop fao specif plant protect product quot evalu consider inform data physic chemic properti activ substanc provid annex ii result evalu thereof ii data physic chemic properti plant protect product provid annex iii propos label claim includ requir recommend plant protect product plant protect product adjuv tank mix physic chemic compat product mixtur evalu decis make gener principl member state impos condit restrict author grant natur sever measur select basi natur extent expect advantag risk aris member state ensur decis respect grant author account agricultur plant health environment includ climat condit area envisag consider result specif condit restrict author grant area member state question member state ensur author amount term rate number applic minimum achiev desir effect higher amount result unaccept risk human anim health environ author amount differenti agricultur plant health environment includ climat condit area author grant rate number applic give rise undesir effect develop resist member state ensur decis respect principl integr control product intend condit principl reli evalu base data limit number repres speci member state ensur plant protect product long term repercuss abund divers target speci issu author member state ensur label product fulfil requir articl direct inform protect user requir commun legisl worker protect specifi condit restrict plant protect product refer point author mention particular articl council direct eec june approxim law member state relat classif packag label danger prepar pesticid articl direct eec issu author member state ensur propos packag accord provis direct eec ensur procedur destruct plant protect product procedur neutral advers effect product accident dispers procedur decontamin destruct packag accord relev regulatori provis author grant requir refer section satisfi specif decis make requir refer part point fulli satisfi author grant advantag plant protect product propos condit outweight advers effect restrict product relat complianc aforement requir mention label complianc requir refer point compromis proper product advantag term advantag compat integr control measur organ farm facilit strategi minim risk develop resist greater divers type activ substanc biochem mode action strategi avoid acceler breakdown soil reduc risk oper consum reduc contamin environ reduc impact target speci criteria refer part point fulli satisfi limit current analyt scienc technolog author grant limit period method submit prove adequ purpos intend case applic time limit develop submit analyt method accord criteria refer author review expiri time limit accord applic reproduc submit analyt method refer part point verifi laboratori author grant year permit applic demonstr reproduc method accord agre criteria author grant requir provid annex member state virtu articl defin prefer close oper applic measur improv perform plant protect product defin close oper applic measur reduc exposur occur plant protect product member state inform applic measur identifi invit applic provid supplementari data inform demonstr perform potenti risk aris chang condit specif principl specif principl appli prejudic gener principl refer section efficaci propos includ recommend control protect organ consid harm basi experi acquir scientif evid normal agricultur plant health environment includ climat condit area propos intend effect consid benefici condit author grant level consist durat control protect intend effect similar result suitabl refer product suitabl refer product exist plant protect product shown give defin benefit term level consist durat control protect intend effect agricultur plant health environment includ climat condit area propos relev yield respons product reduct loss storag quantit qualit similar result suitabl refer product suitabl refer product exist plant protect product shown give consist defin quantit qualit benefit term yield respons reduct loss storag agricultur plant health environment includ climat condit area propos conclus perform prepar valid area member state author hold condit propos propos label specifi prepar intend circumst light infest soil type grow condit propos label claim includ requir prepar plant protect product adjuv tank mix mixtur achiev desir effect compli principl refer point propos label claim includ recommend prepar plant protect product adjuv tank mix member state accept recommend justifi absenc unaccept effect plant plant product relev phytotox effect treat plant plant product propos label limit reduct yield harvest due phytotox effect obtain plant protect product reduct compens advantag enhanc qualiti treat plant plant product unaccept advers effect qualiti treat plant plant product case advers effect process propos label claim prepar appli crop process purpos unaccept advers effect treat plant plant product propag reproduct effect viabil germin sprout root establish propos label claim prepar appli plant plant product propag reproduct unaccept impact succeed crop propos label claim crop affect grown treat crop unaccept impact adjac crop propos label claim prepar appli sensit adjac crop present propos label claim includ requir prepar plant protect product adjuv tank mix mixtur compli principl refer point propos instruct clean applic equip practic effect appli eas ensur remov residu trace plant protect product subsequ damag impact vertebr control author plant protect product intend elimin vertebr grant death synchron extinct conscious death occur immedi vital function reduc gradual sign obviou suffer repel product intend effect obtain unnecessari suffer pain target anim impact human anim health aris plant protect product author grant extent oper exposur handl plant protect product propos condit includ dose applic method exce aoel condit author complianc limit establish activ substanc toxicolog relev compound product accord council direct eec novemb protect worker risk relat exposur chemic physic biolog agent work accord council direct eec june protect worker risk relat exposur carcinogen work sixth special direct mean articl direct eec propos condit requir item protect cloth equip author grant item effect accord relev commun provis readili obtain user feasibl circumst plant protect product take account climat condit plant protect product properti mishandl misus lead high degre risk subject restrict restrict size packag formul type distribut manner plant protect product classifi toxic author profession user wait entri safeti period precaut exposur bystand worker expos applic plant protect product exce aoel level establish activ substanc toxicolog relev compound plant protect product limit valu establish compound accord commun provis refer point wait entri safeti period precaut establish advers impact anim occur wait entri period precaut ensur aoel level limit valu respect realist special precautionari measur prescrib aris residu author ensur residu occur reflect minimum quantiti plant protect product achiev adequ control good agricultur practic appli manner includ pre harvest interv withhold period storag period residu harvest slaughter storag reduc minimum commun maximum residu limit mrl provision mrl nation commun level exist member state establish provision mrl accord articl direct conclus level fix valid circumst influenc residu level crop time applic applic rate frequenc manner circumst plant protect product correspond provision mrl nation commun level establish previous member state grant author plant protect product applic provid evid recommend exce mrl provision mrl establish member state commiss accord articl direct commun mrl exist member state grant author plant protect product applic provid evid recommend exce mrl commun mrl establish accord procedur provid relev commun legisl case refer point applic author accompani risk assess take account worst case potenti exposur consum member state concern basi good agricultur practic take account regist propos author estim dietari exposur exce adi natur residu affect process separ risk assess carri condit provid point treat plant plant product intend fed anim residu occur advers effect anim health influenc environ fate distribut environ author grant activ substanc signific toxicolog ecotoxicolog environment point view metabolit breakdown reaction product plant protect product propos condit test field persist soil year dt gt year dt gt month laboratori test form extract residu amount exceed initi dose dai miner rate dai scientif demonstr field condit accumul soil level unaccept residu succeed crop occur unaccept phytotox effect succeed crop occur unaccept impact environ relev requir provid point author grant concentr activ substanc relev metabolit degrad reaction product groundwat expect exce result plant protect product propos condit lower limit valu maximum permiss concentr laid council direct eec juli relat qualiti water intend human consumpt ii maximum concentr laid commiss includ activ substanc annex basi data toxicolog data concentr laid concentr tenth adi laid activ substanc includ annex scientif demonstr relev field condit lower concentr exceed author grant concentr activ substanc relev metabolit breakdown reaction product expect plant protect product propos condit surfac water exce surfac water area envisag intend abstract drink water valu fix council direct eec june qualiti requir surfac water intend abstract drink water member state impact deem unaccept target speci includ anim relev requir provid point propos instruct plant protect product includ procedur clean applic equip likelihood accident contamin surfac water reduc minimum author grant airborn concentr activ substanc propos condit aoel limit valu oper bystand worker refer part point exceed impact target speci possibl bird target terrestri vertebr expos author grant acut short term toxic exposur ratio bird target terrestri vertebr basi ld long term toxic exposur ratio establish risk assess field condit unaccept impact occur plant protect product propos condit bioconcentr factor bcf relat fat tissu greater establish risk assess field condit unaccept effect occur directli indirectli plant protect product propos condit possibl aquat organ expos author grant toxic exposur ratio fish daphnia acut exposur long term exposur algal growth inhibit exposur ratio maximum bioconcentr factor bcf greater plant protect product activ substanc readili biodegrad greater readili biodegrad establish risk assess field condit unaccept impact viabil expos speci predat occur directli indirectli plant protect product propos condit possibl honeybe expos author grant hazard quotient oral contact exposur honeybe greater establish risk assess field condit unaccept effect honeybe larva honeybe behaviour coloni surviv develop plant protect product propos condit possibl benefici arthropod honeybe expos author grant test organ affect lethal subleth laboratori test conduct maximum propos applic rate establish risk assess field condit unaccept impact organ plant protect product propos condit claim select propos integr pest manag system substanti data possibl earthworm expos author grant acut toxic exposur ratio earthworm long term toxic exposur ratio establish risk assess field condit earthworm popul risk plant protect product propos condit possibl target soil micro organ expos author grant nitrogen carbon miner process laboratori studi affect dai establish risk assess field condit unaccept impact microbi activ plant protect product propos condit take account abil micro organ multipli analyt method method propos reflect state art criteria met order permit valid analyt method propos post registr control monitor purpos formul analysi method determin identifi activ substanc toxicolog ecotoxicolog environment signific impur formul residu analysi method determin confirm residu toxicolog ecotoxicolog environment signific ii recoveri rate rel standard deviat amp le iii repeat valu residu foodstuff gt tabl gt intermedi valu determin interpol log log graph iv reproduc valu residu foodstuff gt tabl gt intermedi valu determin interpol log log graph case residu analysi treat plant plant product foodstuff feedingstuff product anim origin mrl propos mrl limit determin sensit method propos satisfi criteria limit determin relat propos provision commun mrl gt tabl gt physic chemic properti fao specif exist specif met fao specif exist physic chemic properti product meet requir chemic properti shelf life period differ state actual content activ substanc plant protect product exce valu gt tabl gt physic properti plant protect product fulfil physic criteria includ storag stabil relev formul type quot manual develop fao specif plant protect product quot propos label claim includ requir recommend prepar plant protect product adjuv tank mix propos label includ indic compat prepar plant protect product tank mix product adjuv physic chemic compat tank mix extract residu refer quot bound quot quot extract quot residu plant soil defin chemic speci origin pesticid good agricultur practic extract method significantli chang chemic natur residu extract residu consid includ fragment metabol pathwai lead natur product oj direct amend direct eec oj oj direct amend direct eec oj oj direct amend direct ec oj commun mrl mrl establish pursuant council direct eec novemb relat fix maximum level pesticid residu fruit veget council direct eec juli fix maximum level pesticid residu cereal council direct eec juli fix maximum level pesticid residu foodstuff anim origin council regul eec june lai commun procedur establish maximum residu limit veterinari medicin product foodstuff anim origin council direct eec novemb fix maximum level pesticid residu product plant origin includ fruit veget council direct eec march amend direct eec undesir substanc product feedingstuff oj direct amend direct ec oj oj direct amend direct ec oj oj direct amend direct ec oj oj regul amend commiss regul ec oj oj direct amend direct ec oj oj oj direct amend direct eec oj oj direct amend direct eec oj