council direct eec april amend seventh time direct eec approxim law regul administr provis relat classif packag label danger substanc council european commun regard treati establish european econom commun articl thereof regard propos commiss cooper european parliament regard opinion econom social committe dispar law regul administr provis relat classif packag label danger substanc notif substanc member state lead barrier trade member state creat unequ condit competit dispar measur member state direct impact function intern market guarante level protect public health environ measur approxim provis member state object establish function intern market concern health safeti protect man environ basi high level protect order protect man environ potenti risk aris place market substanc lai measur amend reinforc provis council direct eec amend direct eec substanc market notifi compet author mean notif inform case substanc market quantiti tonn year manufactur notif requir reduc quantiti substanc market exce limit provis made addit studi lai measur make introduc notif procedur notif made member state valid commun worthwhil case substanc manufactur commun manufactur appoint exclus repres commun purpos notif order forecast effect man environ advis substanc notifi subject assess risk uniform principl risk assess laid import follow close evolut substanc market institut system substanc list commiss pursuant articl direct eec drew accord guidelin laid commiss decis eec inventori substanc commun market septemb einec inventori publish offici journal european commun reduc minimum number anim experiment purpos accord council direct eec novemb approxim law regul administr provis member state protect anim experiment scientif purpos measur avoid duplic test anim council direct eec decemb harmon law regul administr provis relat applic principl good laboratori practic verif applic test chemic substanc specifi commun principl good laboratori practic test chemic order promot environment protect safeti health work desir safeti data danger substanc profession user provis adopt commun level classif label substanc order promot protect popul worker order ensur adequ level protect man environ introduc measur packag provision label danger substanc appear annex direct eec reason make indic safeti advic mandatori articl direct eec classifi substanc prepar toxic harm corros irrit gener definit experi shown classif improv provid precis criteria classif addit articl direct assess environment hazard make enumar characterist paramet assess establish phase test programm desir add common danger symbol danger environ packag confidenti natur inform cover individu commerci secreci guarante member state allow safeguard measur condit commiss power adapt annex direct eec technic progress adopt direct articl direct eec amend articl replac articl articl object scope purpos direct approxim law regul administr provis member state notif substanc exchang inform notifi substanc assess potenti risk man environ notifi substanc classif packag label substanc danger man environ substanc market member state direct appli prepar finish state intend final user medicin product human veterinari defin direct eec amend direct eec cosmet product defin direct eec amend direct eec mixtur substanc form wast cover direct eec eec foodstuff anim feedingstuff pesticid radioact substanc defin direct eec substanc prepar commun notif approv procedur exist requir equival laid direct month notif direct commiss accord procedur laid articl establish list substanc prepar refer list examin period revis accord procedur addit direct appli carriag danger substanc rail road inland waterwai sea air substanc transit custom supervis provid undergo treatment process oj oj oj oj oj oj oj articl definit purpos direct quot substanc quot mean chemic element compound natur state obtain product process includ addit preserv stabil product impur deriv process exclud solvent separ affect stabil substanc chang composit quot prepar quot mean mixtur solut compos substanc quot polym quot mean substanc consist molecul character sequenc type monom unit compris simpl weight major molecul monom unit coval bound monom unit reactant consist simpl weight major molecul molecular weight molecul distribut rang molecular weight differ molecular weight primarili attribut differ number monom unit context definit quot monom unit quot mean react form monom polym quot notif quot mean document requisit inform present compet author member state substanc manufactur commun manufactur place substanc prepar market substanc manufactur commun person establish commun respons place substanc prepar commun market altern person establish commun purpos submit notif substanc commun market prepar design manfactur sole repres person submit notif refer quot notifi quot quot place market quot mean make parti import commun custom territori deem place market purpos direct quot scientif research develop quot mean scientif experiment analysi chemic research carri control condit includ determin intrins properti perform efficaci scientif investig relat product develop quot process orient research develop quot mean develop substanc pilot plant product trial test field applic substanc quot einec quot mean european inventori exist commerci substanc inventori definit list substanc deem commun market septemb quot danger quot mean direct explos substanc prepar solid liquid pasti gelatin substanc prepar react exotherm atmospher oxygen quickli evolv gase defin test condit deton quickli deflagr heat explod partial confin oxid substanc prepar substanc prepar give rise highli exotherm reaction contact substanc flammabl substanc extrem flammabl substanc prepar liquid substanc prepar extrem low flash point low boil point gaseou substanc prepar flammabl contact air ambient temperatur pressur highli flammabl substanc prepar substanc prepar hot final catch fire contact air ambient temperatur applic energi solid substanc prepar readili catch fire contact sourc ignit continu burn consum remov sourc ignit liquid substanc prepar low flash point substanc prepar contact water damp air evolv highli flammabl gase danger quantiti flammabl substanc prepar liquid substanc prepar low flash point toxic substanc prepar substanc prepar low quantiti death acut chronic damag health inhal swallow absorb skin toxic substanc prepar substanc prepar low quantiti death acut chronic damag health inhal swallow absorb skin harm substanc prepar substanc prepar death acut chronic damag health inhal swallow absorb skin corros substanc prepar substanc prepar contact live tissu destroi irrit substanc prepar corros substanc prepar prolong repeat contact skin mucou membran inflamm sensit substanc prepar substanc prepar inhal penetr skin capabl elicit reaction hypersensit exposur substanc prepar characterist advers effect produc carcinogen substanc prepar substanc prepar inhal ingest penetr skin induc cancer increas incid mutagen substanc prepar substanc prepar inhal ingest penetr skin induc herit genet defect increas incid substanc prepar toxic reproduct substanc prepar inhal ingest penetr skin produc increas incid herit advers effect progeni impair male femal reproduct function capac substanc prepar danger environ substanc prepar enter environ present present delai danger compon environ articl test assess properti substanc test chemic carri framework direct gener principl conduct method laid annex physico chemic properti substanc determin method annex toxic determin method annex ecotox method annex substanc einec test data exist gener method laid annex adequaci data purpos classif label conduct test annex decid case case basi take account factor minim test vertebr anim laboratori test carri complianc principl good laboratori practic provid direct eec provis direct eec real potenti risk man environ assess basi principl adopt april accord procedur laid articl principl regularli review revis accord procedur articl classif substanc classifi basi intrins properti categori laid aricl classif substanc impur account concentr exce concentr limit paragraph articl articl direct eec gener principl classif label substanc prepar appli criteria annex vi save contrari requir danger prepar separ direct annex list substanc classifi accord principl outlin paragraph harmon classif label decis place substanc annex harmon classif label accord procedur laid articl danger substanc list annex character concentr limit paramet enabl assess made health environment hazard prepar danger substanc substanc danger substanc impur oj adapt technic progress oj oj oj oj oj oj oj oj articl duti member state prejudic articl member state measur ensur substanc market prepar notifi compet author member state accord direct packag label accord articl criteria annex vi accord result test provid annex vii viii save case prepar provis exist direct addit member state measur ensur provis safeti data sheet laid articl observ measur refer indent paragraph appli substanc list annex decis list accord procedur laid articl articl oblig carri investig manufactur distributor import danger substanc einec introduc annex oblig carri investig make awar relev access data exist properti substanc basi inform packag provision label substanc rule laid articl criteria annex vi articl full notif prejudic articl notifi substanc requir submit compet author refer articl member state substanc manufactur case manufactur locat commun member state notifi establish notif includ technic dossier suppli inform evalu forese risk delai substanc entail man environ relev data purpos minimum dossier inform result studi refer annex vii detail full descript studi conduct method bibliograph refer declar unfavour effect substanc term forese propos classif label substanc accord direct case danger substanc propos safeti data sheet provid articl case manufactur locat commun notifi accord articl indent includ statement manufactur effect purpos submit notif substanc question design manufactur sole repres desir statement notifi request reason ground notif exempt provis articl maximum period case exce year date notif inform refer notifi provid author preliminari assess risk made accord principl laid articl prejudic articl notifi substanc notifi inform compet author quantiti substanc market reach tonn year manufactur total quantiti market reach tonn manufactur case compet author requir addit test studi laid annex viii level carri time limit determin quantiti substanc market reach tonn year manufactur total quantiti market reach tonn manufactur case compet author requir addit test studi laid annex viii level carri time limit determin notifi give good reason test studi altern scientif test studi prefer quantiti substanc market reach tonn year manufactur total quantiti market reach tonn manufactur case compet author draw programm test studi annex viii level carri notifi time limit compet author determin addit test carri accord requir paragraph voluntarili notifi provid compet author result studi carri articl reduc notif requir substanc market quantiti tonn annum manufactur prejudic articl notifi intend place substanc commun market quantiti tonn annum manufactur requir submit compet author refer articl member state substanc produc case manufactur locat commun member state notifi establish notif includ technic dossier suppli inform evalu forese risk delai substanc entail man environ relev data purpos minimum dossier inform result studi refer annex vii full detail descript studi conduct method bibliograph refer member state notif made requir inform refer articl quantiti market kg year manufactur notifi prejudic articl restrict inform technic dossier notif provid annex vii case notifi submit reduc notif dossier conform paragraph quantiti substanc market reach kg year manufactur total quantiti market reach kg manufactur provid compet author addit inform complet technic dossier level annex vii similarli notifi submit reduc notif dossier conform paragraph quantiti substanc market reach tonn year manufactur total quantiti market reach tonn manufactur submit full notif requir articl substanc notifi conform paragraph notifi expect awar danger properti packag provision label accord rule laid articl criteria impos annex vi label accord principl set articl label bear addit label deriv test carri warn quot caution substanc fulli test quot articl substanc notifi year rule notifi suppli inform requir articl technic dossier annex vii vii vii vii except item thereof data origin submit year previous articl place notifi substanc market substanc notifi articl absenc indic contrari compet author market sooner dai receipt author dossier conform requir direct compet author consid dossier conform direct advis notifi provid articl substanc market dai receipt author inform bring notif conform direct substanc notifi articl absenc indic contrari compet author market sooner dai receipt author dossier conform requir direct compet author consid dossier conform direct advis notifi provid articl substanc market dai receipt author inform bring notif conform direct notifi receiv notic accord articl dossier accept substanc market sooner dai receipt dossier compet author articl substanc manufactur commun substanc manufactur commun notif exist substanc manufactur manufactur cumul yearli tonnag commun market determin commiss nation author basi inform submit articl oblig carri supplementari test accord articl fall collect notifi articl polym polym specif provis technic dossier contain notif refer articl laid annex vii form annex vii accord procedur refer articl articl exempt substanc exempt provis articl substanc einec inventori addit substanc exclus anim feedingstuff cover direct eec eec substanc exclus addit foodstuff cover direct eec substanc exclus flavour foodstuff cover direct eec activ ingredi exclus medicin product refer articl includ chemic intermedi substanc exclus product sector commun notif approv procedur exist requir data submiss equival laid direct month notif direct commiss accord procedur laid articl establish list commun legisl list examin period revis accord procedur substanc list consid notifi mean direct condit fulfil polym except combin form substanc einec substanc market quantiti kg year manufactur provid manufactur import satisfi condit impos member state substanc market condit exce inform provid annex vii point substanc market limit quantiti case exceed kg manufactur year intend sole purpos scientif research develop carri control condit manufactur import make exempt maintain written record ident substanc label data quantiti list custom inform made request compet author member state manufactur import scientif research develop take place substanc market purpos process orient research develop limit number regist custom quantiti limit purpos process orient research develop substanc qualifi exempt period year provid manufactur import commun ident label data quantiti justif quantiti list custom research develop programm compet author member state manufactur import process orient research develop take place compli condit impos author member state research develop condit impos member state includ inform exceed provid articl year substanc subject notif manufactur import give assur substanc prepar incorpor handl custom staff control condit made gener public time prepar addit compet author consid exist unaccept risk man environ extend restrict refer includ product substanc produc process orient research develop year exempt period refer except circumst extend year notifi demonstr satisfact compet author extens justifi substanc refer paragraph manufactur expect awar danger properti packag provision label manufactur repres accord rule laid articl criteria impos annex vi label substanc complet accord principl set articl result test provid annex vii label bear addit label deriv test carri warn quot caution substanc fulli test quot substanc refer paragraph label accord principl set articl toxic toxic carcinogen toxic reproduct mutagen manufactur import substanc transmit compet author inform annex vii section acut toxic data oj oj articl follow inform notifi substanc notifi conform articl respons initi inform write compet author initi notif submit annual total quantiti commun market case substanc manufactur commun notifi design sole repres knowledg effect substanc man environ expect awar substanc market expect awar chang composit substanc annex vii section chang statu manufactur import import substanc produc manufactur establish commun import substanc framework notif previous submit sole repres accord articl requir ensur sole repres provid date inform quantiti substanc introduc commun market articl renotif substanc avoid duplic test vertebr anim case substanc notifi accord articl compet author agre subsequ notifi substanc purpos section annex vii section annex viii refer result test studi forward notifi subsequ notifi provid evid substanc renotifi previous notifi includ degre puriti natur impur notifi give agreement write refer result test studi forward refer made carri test vertebr anim purpos submit notif conform articl prejudic paragraph prospect notifi enquir compet author member state intend subsequ notifi substanc intend notifi notifi address notifi enquiri support evid prospect notifi intent place substanc market quantiti intend place market event compet author receiv enquiri satisfi prospect notifi intend place substanc market quantiti state substanc notifi previous notifi request grant temporari exempt provis articl compet author provid prospect notifi address notifi inform notifi address prospect notifi notifi prospect notifi reason step reach agreement share inform avoid duplic test vertebr anim notifi substanc agre share inform relat annex vii accord paragraph step reach agreement share inform deriv test vertebr anim submit conform articl provis paragraph notifi prospect notifi substanc reach agreement share data member state notifi prospect notifi locat territori introduc nation measur oblig notifi prospect notifi share data view avoid duplic test vertebr anim determin procedur util inform includ regul temporari exempt refer final indent articl reason balanc interest parti concern articl right duti author member state appoint compet author author respons receiv inform provid articl examin conform requir direct shown evalu risk caus substanc compet author inform verif confirmatori test substanc transform product notifi receiv inform direct includ request inform refer annex viii earlier provid articl addition compet author carri sampl control purpos requir notifi suppli quantiti notifi substanc deem carri verif test measur relat safe substanc pend introduct commun provis case substanc notifi accord articl compet author receiv notif carri assess risk accord gener principl laid articl assess includ recommend method test substanc includ recommend measur enabl risk man environ connect market substanc lessen assess updat time time light addit inform provid articl articl case notif submit conform articl period dai receipt notif author inform notifi write notif accept conform direct dossier accept author time advis notifi offici number alloc notif dossier accept author inform notifi inform requir provid order bring dossier conform direct notif submit accord articl compet author period dai receipt notif decid notif conform direct notif adjudg conform inform notifi inform requir provid order bring dossier conform direct notif conform direct author period advis notifi offici number alloc notif substanc manufactur commun notif submit substanc produc manufactur compet author commiss respons calcul annual cumul tonnag commun market tonnag threshold detail articl attain compet author respons receiv notif contact notifi inform ident notifi draw attent collect respons outlin articl procedur laid articl confirm amend propos classif label prejudic articl member state commiss ensur inform commerci exploit manufactur secret articl involv commiss notif procedur member state receiv notif dossier refer articl inform supplementari test carri accord articl follow inform submit conform articl send commiss copi dossier inform summari thereof case inform refer articl compet author notifi commiss test chosen reason choic result assess result case inform receiv conform articl compet author forward commiss element common interest commiss compet author assess risk refer articl summari assess forward commiss articl duti commiss receipt dossier inform refer articl commiss forward copi member state addit commiss forward relev inform collect pursuant direct see fit compet author member state consult directli compet author receiv origin notif commiss specif detail data contain dossier requir direct assess risk provid articl suggest test inform request assess risk modifi compet author receiv origin notif fail compli suggest author inform confirm test amend studi programm provid annex viii assess risk give reason author concern author concern reach agreement author feel basi detail reason addit inform confirm test amend studi programm assess protect man environ commiss decis accord procedur laid articl articl confidenti data consid confidenti problem notifi inform provid articl consid commerci sensit disclosur harm industri commerci wish secret person compet author commiss full justif case respect notif inform submit conform articl industri commerci secreci appli trade substanc manufactur notifi physico chemic data substanc connect section annex vii vii vii wai render substanc harmless summari result toxicolog ecotoxicolog test essenti classif label purpos introduc substanc annex degre puriti substanc ident impur addit danger mean articl recommend method precaut refer annex vii section emerg measur refer annex vii section inform contain safeti data sheet case substanc annex analyt method make detect danger substanc discharg environ determin direct exposur human notifi manufactur import disclos previous confidenti inform inform compet author author receiv notif inform decid respons inform cover industri commerci secreci accord paragraph inform accept confidenti author receiv notif dossier notifi treat confidenti compet author commiss substanc appear list provid articl classifi danger mean direct includ form trade case compet author notif submit request substanc includ list form trade maximum year compet author dossier submit consid public chemic iupac nomenclatur reveal inform commerci exploit manufactur substanc record trade long compet author see fit danger substanc request compet author receiv notif enter list form trade name time introduc annex confidenti inform brought attent commiss member state secret case inform brought attent author respons articl divulg person directli involv administr legal proceed involv sanction undertaken purpos control substanc market person particip heard legisl proceed articl exchang summari dossier data suppli accord articl forward commiss member state summari form case context articl compet author member state commiss access notif dossier addit inform time purpos exchang inform refer articl commiss develop common format format adopt procedur laid articl articl list exist substanc commiss list substanc notifi direct list compil accord provis commiss decis eec commiss alloc eec number substanc contain einec inventori list refer paragraph oj articl packag member state measur ensur danger substanc market packag satisfi requir design construct content escap requir appli special safeti devic prescrib materi constitut packag fasten suscept advers attack content liabl form danger compound content packag fasten strong solid ensur loosen safe meet normal stress strain handl contain fit replac fasten devic design packag refasten repeatedli content escap contain capac substanc sold made gener public label quot toxic quot quot toxic quot quot corros quot defin direct child resist fasten tactil warn danger contain capac substanc sold made gener public label quot harm quot quot extrem flammabl quot quot highli flammabl quot defin direct bear tactil warn danger member state prescrib packag close initi seal packag open time seal irrepar damag categori substanc packag equip devic mention paragraph modifi accord procedur provid articl technic specif relat devic refer paragraph modifi accord procedur provid articl found point annex ix direct articl label member state measur ensur danger substanc market label packag satisfi requir packag show indel substanc design annex substanc list annex internation recogn design full address includ telephon number person establish commun respons place substanc market manufactur import distributor danger symbol laid indic danger involv substanc design danger symbol word indic danger compli laid annex ii symbol print black orang yellow background danger symbol indic danger substanc annex danger substanc appear annex danger symbol indic danger assign rule laid annex vi danger symbol assign substanc oblig symbol make symbol option annex oblig symbol make symbol option oblig symbol make symbol option standard phrase phrase indic special risk aris danger involv substanc word phrase compli laid annex iii phrase substanc annex danger substanc appear annex phrase assign rule laid annex vi standard phrase relat safe substanc phrase word phrase compli laid annex iv phrase substanc annex danger substanc appear annex phrase assign rule laid annex vi eec number alloc eec number obtain einec list refer articl addit substanc appear annex label includ word quot eec label quot case irrit highli flammabl flammabl oxid substanc indic phrase phrase packag ml appli case volum harm substanc retail gener public indic quot toxic quot quot harm quot similar indic label packag substanc subject direct adapt technic progress oj oj articl implement label requir particular requir articl label label firmli affix surfac packag particular read horizont packag set dimens label capac packag dimens millimetr exceed litr greater litr exceed litr greater litr exceed litr greater litr symbol cover tenth surfac area label cm entir surfac label adher packag immedi substanc dimens intend sole provis inform requir direct supplementari health safeti indic label requir particular shown packag paragraph colour present label case paragraph packag danger symbol background stand inform requir label articl stand background size space easili read specif provis present dimens inform laid annex vi accord procedur refer articl member state make place market danger substanc territori subject offici languag languag respect label thereof purpos direct label requir deem satisfi case outer packag packag outer packag label accord intern rule transport danger substanc packag packag label accord direct case singl packag packag label accord intern rule transport danger substanc articl type packag mobil ga cylind accord specif requir refer annex vi danger substanc leav territori member state label permit compli nation rule intern rule transport danger substanc articl exempt label packag requir articl appli provis govern munit explos market view produc practic effect explos pyrotechn effect abovement articl applic provis relat butan propan liquefi petroleum ga april addit member state permit label requir articl appli manner packag small unsuit label accord articl derog articl permit packag danger substanc explos toxic toxic unlabel label small quantiti reason fear danger person handl substanc person packag small label provid articl reason fear danger person handl substanc person derog provis permit packag explos toxic toxic substanc label derog permit symbol indic danger risk phrase safeti phrase laid direct member state make option provid paragraph inform commiss thereof forthwith articl advertis advertis substanc belong categori refer articl prohibit mention made categori categori concern articl safeti data sheet enabl profession user measur protect environ health safeti workplac deliveri danger substanc manufactur import distributor commun recipi safeti data sheet sheet inform protect man environ commun paper electron subsequ manufactur import distributor forward recipi safeti data sheet relev inform substanc gener rule elabor distribut content format safeti data sheet refer paragraph establish accord procedur laid articl articl adapt technic progress amend adapt annex technic progress adopt accord procedur laid articl articl procedur adapt technic progress commiss assist committe compos repres member state chair repres commiss repres commiss submit committe draft measur committe deliv opinion draft time limit chairman lai urgenc matter opinion deliv major laid articl treati case decis council requir adopt propos commiss vote repres member state committe weight manner set articl chairman vote commiss adopt measur envisag accord opinion committe measur envisag accord opinion committe opinion deliv commiss delai submit council propos relat measur council act qualifi major case refer subparagraph expiri period month date referr council council act propos measur adopt commiss period week case refer articl case measur adapt technic progress annex ii vi vii viii expiri period month date referr council council act propos measur adopt commiss save council decid measur simpl major articl free movement claus member state prohibit restrict imped place market substanc compli requir direct ground relat notif classif packag label mean direct articl safeguard claus light inform member state justifi reason substanc accept satisfi requir direct constitut danger man environ reason classif packag label longer temporarili reclassifi prohibit place market substanc subject special condit territori immedi inform commiss member state action give reason decis commiss decis accord procedur refer articl subsequ decis accord paragraph commiss consid case fall paragraph technic adapt annex direct decis matter accord procedur provid articl articl report year member state forward commiss report implement direct respect territori report submit year implement direct year commiss prepar composit report base inform refer paragraph forward member state articl articl annex ii vi vii viii amend annex ii amend addit symbol indic danger environ annex direct annex vi part replac annex direct annex vii replac annex direct annex viii replac annex direct articl direct amend direct eec replac articl articl articl replac articl articl articl direct eec replac articl articl articl replac articl articl articl direct eec replac articl articl articl replac articl articl articl direct eec replac refer direct eec refer present direct eighth recit replac carcinogen mutagen teratogen effect carcinogen mutagen effect effect reproduct articl replac articl direct eec articl direct eec articl articl read prepar regard toxic reproduct assign symbol indic danger quot toxic quot substanc produc effect assign phrase defin annex vi direct eec character substanc toxic reproduct categori concentr equal exceed concentr annex direct eec substanc consider concentr point annex tabl vi direct substanc substanc consider annex direct eec concentr limit articl read prepar regard treat toxic reproduct assign symbol indic danger quot toxic quot substanc produc effect assign phrase defin annex vi direct eec character substanc toxic reproduct categori concentr equal exceed concentr annex direct eec substanc consider concentr point annex tabl vi direct substanc substanc consider annex direct eec concentr limit articl read al prepar regard regard toxic reproduct assign symbol indic danger quot harm quot substanc produc effect assign phrase defin annex vi direct eec character substanc danger reproduct categori concentr equal exceed concentr annex direct eec substanc consider concentr point annex tabl vi direct substanc substanc consider annex direct eec concentr limit replac articl articl articl replac articl articl articl replac articl articl articl ii replac articl articl articl paragraph insert articl inform requir label articl stand background size space easili read specif provis present dimens inform laid annex vi direct eec accord procedur refer articl direct replac articl articl articl replac teratogen effect effect reproduct titl annex part replac teratogen substanc substanc toxic reproduct annex tabl vi articl member state bring forc law regul administr provis compli direct octob forthwith inform commiss therof measur adopt member state refer direct accompani refer occas offici public method make refer laid member state member state commun commiss text provis nation law adopt field govern direct articl direct address member state luxembourg april council presid josé da silva peneda oj oj oj oj oj oj oj oj oj oj direct eec eec ceas appli june date implement direct eec annex symbol text ad annex ii direct eec annex part annex vi direct eec replac gener classif label requir danger substanc part save provid separ direct danger prepar substanc prepar classifi toxic toxic harm criteria acut toxic anim commerci substanc prepar determin method permit estim ld lc classif toxic toxic harm effect paramet refer valu categori ld oral rat mg kg bodyweight ld dermal rat rabbit mg kg bodyweight lc inhal rat mg litr hour toxic amp ge amp ge amp ge toxic harm acut oral toxic anim commerci substanc prepar determin fix dose procedur classif toxic toxic harm effect basi discrimin dose dose level produc evid toxic mortal fix dose level mg kg bodyweight quot evid toxic quot term describ sign toxic administr test substanc sever administr higher fix dose level expect result mortal test method base select dose seri fix dose inappropri give valu classif paramet refer valu categori discrimin dose mg kg bodyweight toxic lt toxic harm mg kg dose level primarili obtain inform sign toxic occur substanc low acut toxic classifi basi acut toxic fact show purpos classif inadvis refer valu paragraph substanc prepar produc effect substanc prepar classifi magnitud effect annex annex vii direct eec replac annex vii inform requir technic dossier quot base set quot refer articl technic scientif give inform reason state subject accept compet author bodi bodi respons carri studi mention ident manufactur ident notifi locat product site substanc manufactur commun purpos notif notifi design manufactur sole repres ident address import bring substanc commun ident substanc name iupac nomenclatur name usual trade abbrevi ca number ca molecular structur formula composit substanc degre puriti natur impur includ isom product percentag signific main impur substanc stabil agent inhibitor addit natur order magnitud ppm spectral data uv ir nmr mass spectrum hplc gc method detect determin full descript method bibliograph refer method detect determin inform analyt method notifi detect substanc transform product discharg environ determin direct exposur human inform substanc product inform section suffici approxim realist estim human environment exposur product process precis detail product process commerci sensit natur requir technolog process product exposur estim relat product work environ environ propos inform section suffici approxim realist estim human environment exposur substanc propos expect type descript function desir effect technolog process es relat substanc exposur estim relat work environ environ form substanc market substanc prepar product concentr substanc market prepar product field applic approxim breakdown industri farmer skill trade public larg ident recipi substanc wast quantiti composit wast result propos estim product import anticip field applic product import tonn year calendar year calendar year substanc manufactur commun purpos notif notifi design manufactur sole repres inform import identifi section product import broken accord express percentag calendar year calendar year recommend method precaut handl storag transport fire natur combust gase pyrolysi propos justifi danger chemic reaction water relev inform suscept substanc explod present form dust emerg measur case accident spillag emerg measur case injuri person poison packag physico chemic properti substanc state substanc oc kpa melt point boil point rel densiti vapour pressur surfac tension water solubl partit coeffici octanol water flash point flammabl explos properti ignit temperatur oxid properti granulometri substanc market form rise danger exposur inhalatori rout test conduct determin particl size distribut substanc market toxicolog studi acut toxic test substanc gase administ rout oral rout choic rout depend natur substanc rout human exposur gase volatil liquid administ inhal rout administ oral administ inhal administ cutan skin irrit ey irrit skin sensit repeat dose rout administr regard rout human exposur acut toxic natur substanc absenc contra indic oral rout prefer repeat dose toxic dai effect mutagen substanc examin test bacteriolog revers mutat test metabol activ bacteriolog test detect chromosom aberr damag absenc contra indic test conduct vitro metabol activ event posit result test test strategi annex carri screen toxic relat reproduct record assess toxicokinet behaviour substanc extent deriv base set data relev inform ecotoxicolog studi effect organ acut toxic fish acut toxic daphnia growth inhibitor test alga bacteri inhibit case biodegrad affect inhibitori effect substanc bacteria test bacteri inhibit carri prior undertak biodegrad degrad biotic antibiot substanc readili biodegrad consider carri test hydrolysi function ph absorpt desorpt screen test possibl render substanc harmless industri skill trade possibl recycl possibl neutral unfavour effect possibl destruct control discharg inciner water purif station public larg possibl recycl possibl neutral unfavour effect possibl destruct control discharg inciner water purif station annex vii inform requir technic dossier quot base set quot refer articl technic scientif give inform reason state subject accept compet author bodi bodi respons carri studi mention addit inform request member state risk assess requir notifi addit inform vapour pressur daphnia acut toxic test ident manufactur ident notifi locat product site substanc manufactur commun purpos notif notifi design manufactur sole repres ident address import bring substanc commun ident substanc name iupac nomenclatur name usual trade abbrevi ca number ca molecular structur formula composit substanc degre puriti natur impur includ isom product percentag signific main impur substanc stabil agent inhibitor addit natur order magnitud ppm spectral data uv ir nmr mass spectrum hplc gc method detect determin full descript method bibliograph refer method detect determin inform analyt method notifi detect substanc transform product discharg environ determin direct exposur human inform substanc product inform section suffici approxim realist estim human environment exposur product process precis detail product process commerci sensit natur requir technolog process es product exposur estim relat product work environ environ propos inform section suffici approxim realist estim human environment exposur substanc propos expect type descript function desir effect technolog process es relat substanc exposur estim relat substanc work environ environ form substanc market substanc prepar product concentr substanc market prepar product field applic approxim breakdown industri farmer skill trade public larg ident recipi substanc estim product import anticip field applic product import tonn year calendar year calendar year substanc manufactur commun purpos notif notifi design manufactur sole repres inform import identifi section product import broken accord express percentag calendar year calendar year recommend method precaut handl storag transport fire natur combust gase pyrolysi propos justifi danger chemic reaction water emerg measur case accident spillag emerg measur case injuri person poison packag physico chemic properti substanc state substanc oc kpa melt point boil point water solubl partit coeffici octanol water flash point flammabl toxicolog studi acut toxic test rout administr suffici substanc gase test oral administr gase test inhal administ oral administ inhal skin irrit ey irrit skin sensit effect mutagen substanc examin bacteriolog revers mutat test metabol activ ecotoxicolog studi degrad biotic annex vii inform requir technic dossier quot base set quot refer articl technic scientif give inform reason state subject accept compet author bodi bodi respons carri studi mention ident manufactur notifi locat product site substanc manufactur commun purpos notif notifi design manufactur sole repres ident address import bring substanc commun ident substanc name iupac nomenclatur name usual trade abbrevi ca number ca molecular structur formula composit substanc degre puriti natur impur includ isom product percentag signific main impur substanc stabil agent inhibitor addit natur order magnitud ppm spectral data uv ir nmr mass spectrum hplc gc method detect determin full descript method bibliograph refer method detect determin inform analyt method notifi detect substanc transform product discharg environ determin direct exposur human inform substanc product inform section suffici approxim realist estim human environment exposur product process precis detail product process commerci sensit natur requir technolog process es product exposur estim relat product work environ environ propos inform section suffici approxim realist estim human environment exposur substanc propos expect type descript function desir effect technolog process es relat substanc exposur estim relat substanc work environ environ form substanc market substanc prepar product concentr substanc market prepar product field applic approxim breakdown industri farmer skill trade public larg ident recipi substanc estim product import anticip field applic product import tonn year calendar year calendar year substanc manufactur commun purpos notif notifi design manufactur sole repres inform import identifi section product import broken accord express percentag calend year calendar year recommend method precaut handl storag transport fire natur combust gase pyrolysi propos justifi danger chemic reaction water emerg measur case accident spillag emerg measur case injuri person poison packag physico chemic properti substanc state substanc oc kpa flash point flammabl toxicolog studi acut toxic rout administr suffici substanc gase test oral administr gase test inhal administ oral administ inhal annex vii annex drawn accord provis articl annex annex viii direct eec replac annex viii addit inform test requir articl technic scientif give inform reason state subject accept compet author bodi bodi respons carri studi level physico chemic studi studi physico chemic properti depend result studi laid annex vii studi includ develop analyt method make observ detect substanc transform product studi thermal decomposit product toxicolog studi fertil studi speci gener male femal rout administr equivoc find gener studi gener requir depend dose schedul studi obtain indic teratogen posit indic examin formal teratolog studi teratolog studi speci rout administr studi requir teratogen examin fertil studi chronic chronic toxic studi includ special studi speci male femal rout administr requir result repeat dose studi annex vii relev inform demonstr investig effect studi includ irrevers lesion low absenc quot effect quot level clear relationship chemic structur substanc studi substanc prove danger addit mutagenesi studi screen studi i carcinogenesi prescrib test strategi annex test base set neg test conduct specif properti purpos substanc test test posit base set supplementari studi includ end point vivo test method basic toxicokinet inform ecotox studi prolong toxic studi daphnia magna dai test higher plant test earthworm toxic studi fish test speci accumul speci prefer fish supplementari degrad studi i suffici degrad prove studi laid annex vii studi absorpt desorpt depend result investig laid annex vii level toxicolog studi test programm cover aspect strong reason contrari support evid chronic toxic studi carcinogen studi fertil studi gener studi effect fertil establish level development toxic studi peri postnat effect teratolog studi speci emploi respect level addit toxicokinet studi cover biotransform pharmacokinet addit test investig organ system toxic ecotoxicolog studi addit test accumul degrad mobil absorpt desorpt toxic studi fish toxic studi bird addit toxic studi organ