commiss regul ec april impos test inform requir import manufactur prioriti substanc accord council regul eec evalu control risk exist substanc text eea relev commiss european commun regard treati establish european commun regard council regul eec march evalu control risk exist substanc articl thereof rapporteur design member state accord articl regul eec evalu inform submit manufactur import respect prioriti substanc consult manufactur import rapporteur determin purpos risk evalu requir manufactur import submit inform carri test inform need evalu substanc question manufactur import manufactur import check test anim replac limit method request manufactur import prioriti substanc submit inform carri test substanc protocol submit rapporteur commiss perform test provis regul accord opinion committe establish pursuant articl regul eec adopt regul articl manufactur import substanc list annex submit inform accord requir articl regul eec provid inform perform test annex deliv result relev rapporteur test perform protocol rapporteur result deliv time limit laid annex articl regul enter forc dai public offici journal european union regul bind entireti directli applic member state brussel april commiss stavro dima member commiss oj regul amend regul ec european parliament council oj annex einec ca substanc rapporteur test inform requir time limit date entri forc regul bi pentabromophenyl ether uk development neurotox studi rat mice month suitabl human bio monitor programm includ breast milk blood trend analysi period annual report period year environment monitor programm includ bird sewag sludg sediment air establish time trend substanc toxic bioaccumul degrad product period ten year annual report period year tri chloro methylethyl phosphat uk irl data releas pattern life cycl stage month tri chloro chloromethyl ethyl phosphat uk irl data releas pattern life cycl stage month sediment water chironomid toxic test spike sediment oecd month sediment water lumbriculu toxic test spike sediment month sediment water hyallella toxic test spike sediment month bi chloromethyl trimethylen bi bi chloroethyl phosphat uk irl data releas pattern life cycl stage month nickel nickel sulphat nickel carbon nickel dichlorid nickel dinitr dk inform ecotox bioavail nickel laboratori studi month inform ecotox fate bioavail field studi month inform toxic nickel soil type month develop valid chronic biotic ligand model rainbow trout month develop valid chronic biotic ligand model alga invertebr month exposur inform deriv pecloc pecregion month monitor data european surfac water month nickel sulphat year oral carcinogen studi nickel sulphat rat oecd month nickel year inhal carcinogen studi element nickel metal powder rat oecd month epoxypropyltrimethyl ammonium chlorid fin simul test aerob sewag treatment activ sludg unit oecd month environment exposur inform month chloro hydroxypropyl trimethyl ammonium chlorid fin simul test aerob sewag treatment activ sludg unit oecd month environment exposur inform month methyl phenylenediamin sediment water lumbriculu toxic test spike sediment month substanc list annex commiss regul ec oj prioriti list substanc list annex commiss regul ec oj prioriti list substanc list annex commiss regul ec oj prioriti list