commiss decis march lai case definit report communic diseas commun network decis ec european parliament council notifi document number ec commiss european commun regard treati establish european commun regard decis ec european parliament council septemb set network epidemiolog surveil control communic diseas commun articl thereof member state commun inform epidemiolog develop emerg public health threat due communic diseas commun network comparison made prevent control action commun nation level compar inform set common case definit prerequisit diseas specif surveil network put place decis effect case definit report commun network compli regul individu data protect case definit compar report compris tier system allow member state structur author flexibl commun inform diseas special health issu case definit facilit report diseas list commiss decis ec case definit construct enabl member state particip report greatest extent data exist system level sensit specif goal inform collect easi amend measur provid decis accord opinion committe set decis ec adopt decis articl purpos submit data epidemiolog surveil control communic diseas provis decis ec articl thereof member state appli case definit annex articl decis adapt extent basi latest scientif data articl decis appli januari articl decis address member state brussel march commiss david byrn member commiss oj oj annex case definit communic diseas list decis ec gener principl applic case definit specif state symptomat case report asymptomat infect regard case infect therapeut public health implic quot case epidemiolog link quot case expos confirm case exposur confirm case eaten food stai hotel tier system level confirm case verifi laboratori analysi probabl case clear clinic pictur link epidemiolog confirm case case indic clinic pictur confirm probabl case classif level vari epidemiolog individu diseas clinic symptom list indic exampl exhaust diseas quot criteria laboratori diagnosi quot list state need confirm case case definit list mean quot applic quot introductori note inform report document intend uniform report compar data commun network clinic descript gener outlin diseas necessarili featur need clinic diagnosi diseas laboratori criteria diagnosi report fulfil test method specif techniqu recommend case definit acquir immunodefici syndrom aid hiv infect aid clinic descript includ human immunodefici viru hiv infect individu clinic condit list european aid surveil case definit criteria diagnosi adult adolesc european aid surveil case definit annex ii ii children ag amp lt year revis european case definit aid surveil children annex iii case classif gt tabl gt hiv infect clinic descript diagnosi base laboratori criteria hiv infect diagnosi aid laboratori criteria diagnosi adult adolesc children ag amp gt month posit result screen hiv antibodi test confirm hiv antibodi test detect hiv nucleic acid rna dna detect hiv hiv antigen test includ neutralis assai hiv isol viral cultur ii children amp lt month posit result separ determin exclud cord blood hiv detect test hiv nucleic acid rna dna detect hiv antigen test includ neutralis assai child amp gt month ag hiv isol viral cultur case classif gt tabl gt anthrax clinic descript inhal anthrax inhal bacillu anthraci prodrom acut febril respiratori failur develop hypoxia dyspnoa radiolog evid mediastin widen cutan anthrax skin lesion evolv papul vesicular stage depress black eschar surround oedema lesion painless constitut disturb fever malais gastointestin anthrax consumpt raw contamin food syndrom sever abdomin pain diarrhoea fever septicaemia laboratori criteria diagnosi isol confirm anthraci specimen collect steril site blood csf lesion affect tissu skin lung gut evid anthraci dna pcr specimen collect steril site blood csf lesion affect tissu skin lung gut demonstr anthraci clinic specimen immunohistochem stain affect tissu skin lung gut nasal swab indic diseas contribut diagnosi case case classif gt tabl gt botul foodborn clinic descript clinic pictur compat botul symptom diplopia blur vision bulbar weak symmetr paralysi progress rapidli laboratori criteria diagnosi detect botulinum toxin serum stool stomach content patient food isol clostridium botulinum stool case classif gt tabl gt brucellosi clinic descript clinic pictur compat brucellosi acut insidi onset fever night sweat undu fatigu anorexia weight loss headach arthralgia laboratori criteria diagnosi demonstr specif antibodi respons demonstr immunofluoresc brucella sp clinic specimen isol brucella sp clinic specimen probabl case singl high titr case classif gt tabl gt campylobact infect clinic descript clinic pictur compat campylobacteriosi diarrhoeal ill variabl sever laboratori criteria diagnosi isol campylobact sp clinic specimen case classif gt tabl gt chlamydia trachomati genit infect clinic descript clinic pictur compat chlamydia trachomati infect urethr epididym cervic acut salping syndrom sexual transmit laboratori criteria diagnosi isol trachomati cultur specimen uro genit tract demonstr trachomati clinic specimen uro genit tract detect antigen nucleic acid case classif gt tabl gt cholera clinic descript clinic pictur compat cholera wateri diarrhoea vomit sever variabl laboratori criteria diagnosi isol toxigen cholera toxin produc vibrio cholera stool vomitu demonstr specif anti toxin vibrocid antibodi respons case classif gt tabl gt cryptosporidiosi clinic descript clinic pictur compat cryptosporidiosi characteris diarrhoea abdomin cramp loss appetit nausea vomit laboratori criteria diagnosi demonstr cryptosporidium oocyst stool demonstr cryptosporidium intestin fluid small bowel biopsi specimen demonstr cryptosporidium antigen stool case classif gt tabl gt diphtheria clinic descript clinic pictur compat diphtheria upper respiratori tract ill characteris sore throat low grade fever adher membran tonsil pharynx nose laboratori criteria diagnosi isol toxin produc corynebacterium diphtheria clinic specimen histopatholog diagnosi diphtheria case classif gt tabl gt note asymptomat carrier case toxigen diphteria cutan diphteria report echinococcosi clinic descript clinic pictur compat echinococcosi produc clinic syndrom vari cyst size locat laboratori criteria diagnosi diagnosi histopatholog combin imag techniqu serolog test indirect haemagglutin immunodiffus immunoblot assai case classif gt tabl gt ehec infect entero haemorrhag escherichia coli clinic descript clinic pictur compat ehec infect diarrhoea bloodi abdomin cramp ill complic haemolyt uraem syndrom hu thrombot thrombocytopen purpura ttp laboratori criteria diagnosi isol coli belong sero group enterohaemorrhag diseas serolog confirm patient hu ttp probabl case detect gene code st st product case classif gt tabl gt giardiasi clinic descript clinic pictur compat infect giardia lamblia characteris diarrhoea abdomin cramp bloat weight loss malabsorpt laboratori criteria diagnosi demonstr lamblia cyst stool demonstr lamblia trophozoit stool duoden fluid small bowel biopsi demonstr lamblia antigen stool case classif gt tabl gt gonorrhoea clinic descript clinic pictur compat gonorrhoea urethr cervic salping laboratori criteria diagnosi isol neisseria gonorrhoea clinic specimen detect gonorrhoea antigen nucleic acid demonstr gram neg intracellular diplococci urethr smear male case classif gt tabl gt haemophilu influenza type invas clinic descript clinic pictur compat invas diseas bacteremia mening arthriti epiglott osteomyel cellul laboratori criteria diagnosi isol haemophilu influenza type steril site detect influenza nucleic acid steril site probabl case detect influenza antigen steril site case classif gt tabl gt hepat viral clinic descript symptomat case clinic pictur compat hepat discret onset symptom jaundic elev serum aminotransferas level hepat acut laboratori criteria diagnosi igm antibodi hepat viru anti hav posit detect antigen stool detect nucleic acid serum case classif gt tabl gt hepat acut laboratori criteria diagnosi igm antibodi hepat core antigen anti hbc posit detect hbv nucleic acid serum case classif gt tabl gt hepat laboratori criteria diagnosi detect hcv specif antibodi detect hcv nucleic acid clinic sampl case classif gt tabl gt hiv infect acquir immunodefici syndrom influenza clinic descript clinic pictur compat influenza sudden onset diseas cough fever amp gt muscular pain headach laboratori criteria diagnosi detect influenza antigen influenza viru specif rna isol influenza viru demonstr specif serum antibodi respons influenza case classif gt tabl gt legionellosi legionnair diseas clinic descript pneumonia pontiac fever clinic descript limit influenza ill characteris fever headach myalgia product cough patient recov spontan therapi dai sign pneumonia laboratori criteria diagnosi legionellosi isol legionella organ respiratori secret lung tissu blood demonstr specif antibodi respons legionella pneumophila serogroup serogroup legionella speci indirect immunofluoresc antibodi test microagglutin detect specif legionella antigen urin valid reagent probabl case singl high titr specif serum antibodi pneumophila serogroup serogroup legionella speci detect specif legionella antigen respiratori secret direct fluoresc antibodi dfa stain organ respiratori secret lung tissu evalu monoclon reagent case classif gt tabl gt leptospirosi clinic descript clinic pictur compat leptospirosi characteris fever headach chill myalgia conjunctiv suffus frequent mening rash jaundic renal insuffici laboratori criteria diagnosi isol leptospira clinic specimen demonstr specif increas leptospira agglutin titr demonstr leptospira clinic specimen immunofluoresc detect leptospira igm antibodi serum case classif gt tabl gt listeriosi clinic descript infect caus listeria monocytogen produc clinic syndrom includ stillbirth listeriosi newborn mening bacteremia localis infect laboratori criteria diagnosi isol monocytogen steril site blood cerebrospin fluid commonli joint pleural pericardi fluid case classif gt tabl gt malaria clinic descript clinic pictur compat malaria fever common symptom includ headach back pain chill sweat myalgia nausea vomit diarrhoea cough laboratori criteria diagnosi demonstr malaria parasit blood film detect plasmodium nucleic acid case classif gt tabl gt measl clinic descript clinic pictur compat measl generalis rash last amp gt dai temperatur amp gt cough coryza koplik spot conjunct laboratori criteria diagnosi detect igm antibodi measl absenc recent vaccin demonstr specif measl antibodi respons absenc recent vaccin detect measl viru vaccin strain clinic specimen case classif gt tabl gt meningococc diseas clinic descript clinic pictur compat meningococc diseas mening meningococcemia progress rapidli purpura fulminan shock death manifest laboratori criteria diagnosi isol neisseria meningitidi steril site blood cerebrospin fluid csf commonli joint pleural pericardi fluid detect meningitidi nucleic acid steril site detect meningitidi antigen steril site demonstr gram neg diplococci steril site microscopi probabl case singl high titr meningococc antibodi convalesc serum case classif gt tabl gt note asymptomat carrier report mump clinic descript clinic pictur compat mump acut onset uni bilater tender limit swell parotid salivari gland last amp gt dai appar laboratori criteria diagnosi detect mump igm antibodi demonstr specif mump antibodi respons absenc recent vaccin isol mump viru vaccin strain clinic specimen detect mump nucleic acid case classif gt tabl gt pertussi whoop cough clinic descript clinic pictur compat pertussi cough ill last week paroxysm cough inspiratori quot whoop quot post tussiv vomit appar laboratori criteria diagnosi demonstr specif pertussi antibodi respons absenc recent vaccin detect nucleic acid isol bordetella pertussi clinic specimen case classif gt tabl gt plagu clinic descript diseas character fever chill headach malais prostrat leukocytosi manifest princip clinic form region lymphaden bubon plagu septicaemia evid bubo septicem plagu plagu pneumonia pharyng cervic lymphaden laboratori criteria diagnosi isol yersinia pesti clinic specimen demonstr specif antibodi respons pesti antigen probabl case elev serum antibodi titr pesti fraction antigen document specif chang patient histori plagu vaccin detect antigen clinic specimen fluoresc assai case classif gt tabl gt poliomyel paralyt clinic descript clinic pictur compat poliomyel acut onset flaccid paralysi limb decreas absent tendon reflex affect limb appar sensori cognit loss laboratori criteria diagnosi isol polioviru clinic specimen detect polio viru nucleic acid case classif gt tabl gt rabi human clinic descript rabi acut encephalomyel progress coma death dai symptom laboratori criteria diagnosi detect direct fluoresc antibodi viral antigen clinic specimen prefer brain nerv surround hair follicl nape neck detect rabi nucleic acid clinic specimen isol cell cultur laboratori anim rabi viru saliva cerebrospin fluid csf central nervou system tissu identif rabi neutralis antibodi titr complet neutral serum csf unvaccin person case classif gt tabl gt rubella clinic descript clinic pictur compat rubella acut onset gener maculopapular rash arthralgia arthriti lymphadenopathi conjunct laboratori criteria diagnosi detect rubella igm antibodi absenc recent vaccin demonstr specif rubella antibodi respons absenc recent vaccin isol rubella viru absenc recent vaccin detect rubella nucleic acid clinic specimen case classif gt tabl gt salmonellosi typhi paratyphi clinic descript clinic pictur compat salmonellosi diarrhoea abdomin pain nausea vomit organ extraintestin infect laboratori criteria diagnosi isol salmonella typhi paratyphi clinic specimen case classif gt tabl gt shigellosi clinic descript ill variabl sever characteris diarrhoea fever nausea cramp tenesmu laboratori criteria diagnosi isol shigella sp clinic specimen case classif gt tabl gt streptococcu pneumonia invas diseas clinic descript steptococcu pneumonia clinic syndrom depend site infect acut otiti media pneumonia bacteremia mening laboratori criteria diagnosi isol pneumonia steril site blood cerebrospin fluid commonli joint pleural pericardi fluid detect pneumonia nucleic acid steril site probabl case detect pneumonia antigen steril site case classif gt tabl gt syphili syphili primari clinic descript stage infect treponema pallidum characteris chancr ulcer chancr differ consider clinic appear laboratori criteria diagnosi detect specif igm eia demonstr pallidum clinic specimen dark field microscopi direct fluoresc antibodi dfa tp equival method probabl case reactiv serolog test nontreponem vener diseas research laboratori vdrl rapid plasma reagin rpr treponem fluoresc treponem antibodi absorb fta ab microhemagglutin assai antibodi pallidum mha case classif gt tabl gt syphili secondari clinic descript stage infect caus pallidum characteris localis diffus mucocutan lesion generalis lymphadenopathi primari chancr present laboratori criteria diagnosi demonstr pallidum clinic specimen dark field microscopi direct fluoresc antibodi dfa tp equival method probabl case reactiv serolog test nontreponem vener diseas research laboratori vdrl rapid plasma reagin rpr treponem fluoresc treponem antibodi absorb fta ab microhaemagglutin assai antibodi pallidum mha tp case classif gt tabl gt syphli latent clinic descript stage infect caus pallidum organ persist bodi infect person caus symptom sign laboratori criteria diagnosi demonstr posit reaction specif eia neg laboratori test infecti syphili primari secondari syphili case classif gt tabl gt tetanu clinic descript clinic pictur compat tetanu acut onset hypertonia pain muscular contract muscl jaw neck generalis muscl spasm appar medic laboratori criteria diagnosi detect tetanu toxoid antibodi unvaccin untreat patient demonstr specif tetanu toxoid antibodi respons case classif gt tabl gt toxoplasmosi clinic descript protozoan diseas present acut ill lymphadenopathi enceph chorioretin disfunct central nervou system congenit infect occur hydrocephalu microcephalu intracerebr calcif convuls cerebr retard laboratori criteria diagnosi demonstr specif toxoplasma antibodi respons demonstr agent bodi tissu fluid isol anim cell cultur detect toxoplasma nucleic acid case classif gt tabl gt trichinosi clinic descript diseas caus ingest trichinella larva diseas variabl clinic manifest common sign symptom symptomat person includ eosinophilia fever myalgia periorbit oedema laboratori criteria diagnosi demonstr trichinella larva tissu obtain muscl biopsi demonstr specif trichinella antibodi respons case classif gt tabl gt tuberculosi clinic criteria clinician judgement clinic radiolog sign symptom compat tuberculosi clinician decis treat patient full anti tuberculosi therapi laboratori criteria isol mycobacterium tuberculosi complex bovi bcg clinic specimen cultur evid acid fast bacilli afb microscop examin spontan induc sputum classif laboratori criteria definit case isol tuberculosi complex bovi bcg clinic specimen countri cultur routin case sputum smear examin posit afb consid definit case definit case meet clinic criteria meet laboratori criteria definit case classif site diseas pulmonari tuberculosi tuberculosi lung parenchyma tracheo bronchial tree extrapulmonari tuberculosi tuberculosi affect site pulmonari defin classif previou anti tuberculosi treatment treat case receiv treatment activ tuberculosi past receiv anti tuberculosi drug month previous treat case diagnos activ tuberculosi past receiv anti tuberculosi drug exclud prevent therapi month typhoid paratyphoid fever clinic descript ill caus salmonella typhi paratyphii characteris insidi onset sustain fever headach malais anorexia rel bradycardia constip diarrhoea nonproduct cough mild atyp infect occur laboratori criteria diagnosi isol typhi paratyphii blood stool clinic specimen case classif gt tabl gt variant creutzfeldt jakob diseas clinic descript histori progress neuropsychiatr disord durat ill amp gt month routin investig suggest altern diagnosi histori potenti iatrogen exposur ii clinic featur earli psychiatr symptom persist pain sensori symptom ataxia myoclonu chorea dystonia dementia laboratori criteria diagnosi eeg show typic appear classic cjd eeg perform bilater pulvinar high signal mri scan characterist neuropatholog immunopatholog find case classif gt tabl gt viral haemorrhag fever ebola marburg fever clinic descript begin acut fever diarrhoea bloodi vomit headach nausea abdomin pain common haemorrhag manifest follow patient show maculopapular rash trunk laboratori criteria diagnosi posit viru isol posit skin biopsi immunohistochemistri detect ebola marburg viru nucleic acid posit serolog late diseas case classif gt tabl gt lassa fever clinic descript ill gradual onset malais fever headach sore throat cough nausea vomit diarrhoea myalgia chest pain haemorrhag manifest follow laboratori criteria diagnosi viru isol posit skin biopsi immunohistochemistri detect lassa viru nucleic acid posit serolog late diseas case classif gt tabl gt congo crimean haemorrhag fever clinic descript ill gradual onset acut high fever chill myaliga nausea anorexia vomit headach backach haemorrhag manifest follow laboratori criteria diagnosi viru isol detect cchf viru nucleic acid posit serolog late diseas case classif gt tabl gt yellow fever clinic descript ill characteris acut onset constitut symptom remiss recurr fever hepat albuminuria instanc renal failur shock generalis hæmorrhag laboratori criteria diagnosi demonstr specif yellow fever antibodi respons patient histori recent yellow fever vaccin cross reaction flavivirus exclud viru isol detect yellow fever antigen detect yellow fever nucleic acid case classif gt tabl gt yersiniosi clinic descript ill variabl sever characteris diarrhoea fever nausea cramp tenesmu laboratori criteria diagnosi isol yersinia enterocolitica pseudotubeculosi clinic specimen case classif gt tabl gt