council direct septemb amend sixth time direct eec approxim law regul administr provis relat classif packag label danger substanc eec council european commun regard treati establish european econom commun articl thereof regard propos commiss regard opinion european parliament regard opinion econom social committe protect man environ potenti risk aris place market substanc lai measur reinforc recommend provid council direct eec june approxim law regul administr provis relat classif packag label danger substanc amend direct eec reason amend direct eec moment adequ classif packag label danger substanc protect popul princip worker order control effect man environ advis substanc market subject prior studi manufactur import notif compet author convei mandatorili inform import follow close evolut substanc market order institut system substanc list direct properli appli draw inventori substanc commun market septemb provid measur make introduc procedur notif member state valid commun provid measur relat classif label substanc laid commun level introduc measur packag provision label danger substanc appear annex direct eec make indic safeti advic obligatori articl abovement direct classifi substanc prepar toxic harm corros irrit gener definit experi shown improv classif absenc moment specif alloc class provid precis criteria classif addit articl direct evalu danger environ enumer characterist paramet assess establish phase studi programm adopt direct articl articl direct eec replac articl quot articl purpos direct approxim law regul administr provis member state oj oj oj oj notif substanc classif packag label substanc danger man environ market member state direct appli provis relat medicin product narcot radioact substanc carriag danger substanc rail road inland waterwai sea air foodstuff feedingstuff substanc form wast cover council direct eec juli relat wast council direct eec march relat toxic danger wast substanc transit custom supervis provid undergo treatment process articl appli provis govern contain gase compress liquefi dissolv pressur exclud aerosol compli requir council direct eec approxim law member state relat aerosol dispens munit explos market view produc practic effect explos pyrotechn effect articl concern notif appli month public inventori refer articl substanc market septemb month public inventori refer articl substanc inventori pesticid fertil subject approv procedur equival commun notif procedur procedur harmon substanc subject similar test notif requir exist direct articl purpos direct quot substanc quot mean chemic element compound occur natur state produc industri includ addit requir purpos place market quot prepar quot mean mixtur solut compos substanc quot environ quot mean water air land inter relationship relationship live organ quot notif quot mean document manufactur person establish commun place substanc prepar market present requisit inform compet author member state person hereinaft refer quot notifi quot quot place market quot mean suppli make parti import commun custom territori deem place market purpos direct substanc prepar quot danger quot mean direct explos substanc prepar explod effect flame sensit shock friction dinitrobenzen oxid substanc prepar give rise highli exotherm reaction contact substanc flammabl substanc extrem flammabl liquid substanc prepar flash point lower ºc boil point lower equal ºc oj oj oj highli flammabl substanc prepar hot final catch fire contact air ambient temperatur applic energi solid substanc prepar readili catch fire contact sourc ignit continu burn consum remov sourc ignit liquid substanc prepar flash point ºc gaseou substanc prepar flammabl air normal pressur substanc prepar contact water damp air evolv highli flammabl gase danger quantiti flammabl liquid substanc prepar flash point equal greater ºc equal ºc toxic substanc prepar inhal ingest penetr skin involv extrem acut chronic health risk death toxic substanc prepar inhal ingest penetr skin involv acut chronic health risk death harm substanc prepar inhal ingest penetr skin involv limit health risk corros substanc prepar contact live tissu destroi irrit corros substanc prepar prolong repeat contact skin mucou membran inflamm danger environ substanc prepar present present delai risk environ carcinogen substanc prepar inhal ingest penetr skin induc cancer man increas incid teratogen mutagen articl physico chemic properti substanc prepar determin method annex toxic determin method annex ecotox annex real potenti environment hazard assess characterist set annex vii viii basi exist internation recogn paramet gener principl classif label substanc prepar appli criteria annex vi save contrari requir danger prepar separ direct articl classif danger substanc degre hazard specif natur risk involv base categori laid articl categori substanc classifi greatest degre hazard accord articl danger substanc list annex rate enabl health hazard prepar assess rate determin accord criteria establish subsequ council direct articl member sate measur ensur prejudic articl substanc market prepar substanc notifi compet author member state accord direct packag label accord articl criteria annex vi accord result test provid articl measur refer indent paragraph appli substanc list annex decis list accord procedur laid articl danger substanc appear annex includ list refer articl market septemb manufactur establish commun expect awar danger properti packag provision label manufactur repres accord rule laid articl criteria annex vi articl prejudic articl manufactur import commun substanc mean direct requir submit compet author refer articl member state substanc produc import commun latest dai substanc market notif includ technic dossier suppli inform evalu forese risk delai substanc entail man environ inform result studi refer annex vii detail full descript studi conduct method bibliograph refer declar unfavour effect substanc term envisag propos classif label substanc accord direct propos recommend precaut relat safe substanc case substanc notifi compet author agre notifi substanc purpos technic dossier refer result studi carri previou notifi provid agreement write substanc list annex notifi present declar unfavour effect propos classif propos recommend precaut relat safe notifi suppli inform requir technic dossier annex vii except point annex substanc origin notifi year previous notifi substanc notifi requir inform compet author annual total quantiti market accord tonnag rang laid annex vii point knowledg effect substanc man environ expect awar substanc market mean annex vii point expect awar chang properti result modif substanc refer annex vii point notifi requir inform compet author result studi carri accord annex viii articl member state appoint compet author author respons receiv inform provid articl examin conform requir direct notifi propos find forese risk substanc entail classif label propos recommend precaut relat safe submit notifi shown evalu hazard caus substanc compet author inform verif test substanc notifi includ request inform refer annex viii earlier provid carri sampl control purpos measur relat safe substanc pend introduct commun provis procedur laid articl confirm amend propos classif label recommend precautionari measur provid annex vii point member state commiss ensur inform commerci exploit manufactur secret articl substanc list consid notifi mean direct condit fulfil polymeriz polycondens polyadduct combin form monom unmarket septemb substanc research analysi purpos market purpos determin properti accord direct substanc market research analysi purpos quantiti tonn year manufactur import intend sole laboratori substanc market quantiti tonn year manufactur provid manufactur announc ident label data quantiti compet author member state substanc market compli condit impos author substanc market research develop stage limit number regist custom quantiti limit purpos research develop amount tonn year manufactur qualifi exempt period year provid manufactur announc ident label data quantiti compet author member state manufactur research develop take place compli condit impos author research develop period substanc subject notif manufactur give assur substanc prepar incorpor handl custom staff control condit made public substanc refer paragraph manufactur expect awar danger properti packag provision label manufactur repres accord rule laid articl criteria impos annex vi label accord principl set articl label bear warn quot caution substanc fulli test quot substanc refer paragraph label accord principl set articl toxic toxic manufactur import substanc transmit compet author inform annex vii point articl member state receiv notif dossier addit inform refer articl forthwith send commiss copi dossier summari thereof relev comment case inform refer articl addit inform studi provid annex viii compet author notifi commiss test chosen reason choic assess result articl receipt copi notif dossier summari thereof addit inform member state commiss forward notif dossier summari thereof member state relev inform collect pursuant direct member state compet author member state consult direct compet author receiv origin notif commiss specif detail data contain dossier requir direct suggest test inform request compet author receiv origin notif fail compli suggest author inform amend studi programm provid annex viii give reason author concern author concern reach agreement author feel basi detail reason addit inform amend studi programm protect man environ commiss decis accord procedur laid articl articl consid confidenti problem notifi inform provid articl consid commerci sensit disclosur harm industri commerci wish secret person compet author commiss full justif case industri commerci secreci appli trade substanc physico chemic data substanc connect annex vii point wai render substanc harmless interpret toxicolog ecotoxicolog test bodi respons test recommend method precaut refer annex vii point emerg measur refer annex vii point notifi subsequ disclos previous confidenti inform requir inform compet author author receiv notif decid respons inform cover industri commerci secreci accord paragraph substanc appear list provid articl includ encod form compet author notif submit request confidenti problem public substanc give rise provid substanc classifi danger substanc includ list encod form longer year confidenti inform brought attent commiss member state secret case inform brought attent author respons articl administr legal proceed involv sanction undertaken purpos control substanc market divulg person directli involv proceed articl articl oblig member state legisl administr practic impos stricter limit protect industri commerci secreci laid articl suppli inform state concern step compli stricter limit articl data suppli accord articl forward commiss member state summari form case context articl compet author member state commiss access notif dossier addit inform time articl commiss basi inform provid member state draw inventori substanc commun market septemb regard articl inventori give chemic internation recogn chemic nomenclatur prefer iupac ca number common iso abbrevi commiss list substanc notifi direct inform form record list inventori criteria cover provis commiss member state inform relat inventori determin accord procedur laid articl articl annex list substanc classifi accord articl recommend relat safe articl member state measur ensur danger substanc market packag satisfi requir design construct content escap requir appli special safeti devic prescrib materi constitut packag fasten suscept advers attack content liabl form harm danger compound content packag fasten strong solid ensur loosen safe meet normal stress strain handl contain fit replac fasten devic design packag repeatedli refasten content escap member state prescrib packag initi close seal packag open time seal irrepar damag contain capac exceed litr danger substanc intend domest child resist fasten contain capac exceed litr toxic toxic corros liquid intend domest carri tactil warn danger technic specif regard devic refer paragraph adopt procedur articl annex ix annex ix relat child resist fasten annex ix relat tactil warn danger articl member state measur ensur danger substanc market label packag satisfi requir packag show indel substanc origin substanc danger symbol laid indic danger involv substanc standard phrase indic special risk aris danger standard phrase indic safeti advic relat substanc substanc term list annex case accord internation recogn nomenclatur indic origin includ address manufactur distributor import symbol indic danger explos explod bomb oxid flame circl extrem flammabl flame highli flammabl flame toxic skull cross bone toxic skull cross bone harm st andrew cross xn corros symbol show damag effect acid irrit st andrew cross xi symbol conform annex ii print black orang yellow background special risk involv substanc standard phrase accord refer contain list annex set annex iii case substanc list annex refer special risk attribut danger substanc compli indic annex iii phrase quot extrem flammabl quot quot highli flammabl quot repeat word indic danger accord safeti advic relat substanc standard phrase accord refer contain list annex set annex iv packag accompani safeti advic requir paragraph materi imposs label packag case substanc list annex safeti advic relat danger substanc compli indic annex iv indic quot toxic quot quot harm quot similar indic label packag substanc subject direct case irrit highli flammabl flammabl oxid substanc indic special risk safeti advic packag ml appli case volum harm substanc retail gener public danger symbol assign substanc oblig symbol make symbol option annex includ provis contrari oblig symbol make symbol option oblig symbol make symbol option articl particular requir articl label label firmli affix surfac packag particular read horizont packag set dimens label gt pic file quot quot gt symbol cover tenth surfac area label cm entir surfac label adher packag immedi substanc dimens intend sole provis inform requir direct supplementari health safeti indic label requir particular shown packag paragraph colour present label case paragraph packag danger symbol background stand member state make place market danger substanc territori subject offici languag languag respect label thereof purpos direct label requir deem satisfi case outer packag packag outer packag label accord intern rule transport danger substanc packag packag label accord direct case singl packag packag label accord intern rule transport danger substanc articl danger substanc leav territori member state label permit compli nation rule intern rule transport danger substanc articl member state permit label requir articl appli manner packag small unsuit label accord articl derog articl permit packag danger substanc explos toxic toxic unlabel label small quantiti reason fear danger person handl substanc person member state make option provid paragraph forthwith inform commiss thereof articl amend adapt annex annex vi part annex vii viii technic progress adopt accord procedur laid articl articl committe hereinaft call quot committe quot set adapt technic progress direct elimin technic barrier trade danger substanc prepar consist repres member state commiss repres chairman committe adopt rule procedur articl refer made procedur laid articl matter refer committe chairman initi request repres member state commiss repres submit draft measur adopt committe committe give view draft time limit set chairman regard urgenc matter decis major vote vote member state weight provid articl treati chairman vote commiss adopt propos measur accord opinion committe propos measur accord opinion committe opinion state commiss delai submit propos council measur adopt council act qualifi major council act month propos submit propos measur adopt commiss articl member state ground relat notif classif packag label mean direct prohibit restrict imped place market substanc compli requir direct annex thereto articl member state detail evid substanc satisfi requir direct constitut hazard man environ reason classif packag label provision prohibit sale substanc subject special condit territori immedi inform commiss member state action give reason decis commiss consult member state concern week give view delai measur commiss consid technic adapt direct adapt adopt commiss council accord procedur laid articl case member state adopt safeguard measur maintain adapt enter forc quot articl articl direct eec articl articl annex direct eec replac annex ix direct articl amend made direct list direct eec replac quot articl quot quot articl quot articl replac quot articl quot quot articl quot articl direct eec replac quot articl quot quot articl quot articl replac quot articl quot quot articl quot articl direct eec replac quot articl quot quot articl quot articl replac quot articl quot quot articl quot articl articl septemb member state implement law regul administr provis compli articl articl articl direct eec amend direct inform commiss thereof septemb implement law regul administr provis compli articl direct eec amend direct inform commiss thereof septemb member state adopt publish law regul administr provis compli articl direct eec amend direct enter forc septemb transit period direct forc member state forward notif dossier inform collect commiss provid articl direct eec amend direct effect case member state provis articl direct eec amend direct relat notif appli articl direct address member state brussel septemb council presid kennedi annex method determin physico chemic properti record method determin toxic record method determin ecotox record annex vi gener classif label requir danger substanc part save provid separ direct danger prepar substanc prepar classifi toxic toxic harm criteria classif toxic toxic harm effect determin acut toxic commerci substanc prepar anim express ld lc valu paramet refer valu gt pic file quot quot gt fact show purpos classif inadvis ld lc valu princip basi substanc prepar produc effect substanc prepar classifi magnitud effect part ii corros criteria record irrit criteria record fact show exist effect acut effect experi anim carcinogen mutagen allergen acut chronic effect substanc prepar classifi magnitud effect guid label danger substanc criteria choic phrase alloc danger substanc indic special risk phrase safeti advic phrase record annex vii inform requir technic dossier quot base set quot refer articl give notif manufactur person place substanc market provid inform set technic give inform reason state test conduct method recogn recommend compet intern bodi recommend exist bodi carri test compli principl good current laboratori practic complet studi result obtain submit state test conduct substanc market composit sampl addit descript method refer standard internation recogn method mention technic dossier bodi bodi respons carri studi ident substanc name iupac nomenclatur name usual trade abbrevi ca number empir structur formula composit substanc degre puriti natur impur includ isom product percentag signific main impur substanc stabil agent inhibitor addit natur order magnitud ppm spectral data uv ir nmr method detect determin full descript method bibliograph refer gt pic file quot quot gt gt pic file quot quot gt gt pic file quot quot gt gt pic file quot quot gt gt pic file quot quot gt annex viii addit inform test requir articl person notifi substanc compet author accord requir articl direct provid request author inform carri addit test provid annex technic give inform reason state test conduct method recogn recommend compet intern bodi recommend exist bodi carri test compli principl good current laboratori practic complet studi result obtain submit state test conduct substanc market composit sampl addit descript method refer standard internation recogn method mention technic dossier bodi bodi respons carri studi level take account current knowledg substanc plan result test carri context base set compet author requir addit studi quantiti substanc market notifi reach level tonn year total tonn condit test fulfil case substanc toxicolog studi fertil studi speci gener male femal rout administr equivoc find gener studi gener requir studi obtain evid teratogen indic teratogen full evalu teratogen potenti requir studi speci teratolog studi speci rout administr studi requir teratogen examin evalu preced fertil studi chronic chronic toxic studi includ special studi speci male femal rout administr result acut studi annex vii relev inform demonstr investig form detail examin effect prolong exposur dai longer year effect studi includ irrevers lesion low absenc quot effect quot level clear relationship chemic structur substanc studi substanc prove danger addit mutagenesi studi includ screen carcinogenesi result mutagenesi test neg test verifi mutagenesi test verifi carcinogenesi screen obligatori result mutagenesi verif test neg mutagenesi test level result posit mutagenesi test carri result carcinogenesi screen verif test neg carcinogenesi screen verif test level result posit carcinogenesi screen verif test carri result mutagenesi test posit singl posit test mean posit verif test level mutagenesi test carcinogenesi screen test consid posit result carcinogenesi screen test lead carcinogenesi studi level ecotoxicolog studi algal test speci growth inhibit test prolong toxic studi daphina magna dai studi includ determin quot effect level quot reproduct quot effect level quot lethal condit test carri determin accord procedur articl light method laid annex acut toxic test daphnia test higher plant test earthworm prolong toxic studi fish oryzia jordanella period dai studi includ determin quot threshold level quot condit test carri determin accord procedur articl light method adopt annex acut toxic test fish test speci accumul speci prefer fish poecilla reticulata prolong biodegrad studi suffici bio degrad prove studi laid annex vii test dynam chosen lower concentr inoculum flow system case notifi inform compet author quantiti substanc market reach level tonn year total tonn receipt notif requisit condit fulfil compet author time limit determin requir test carri case altern scientif studi prefer level quantiti substanc market notifi reach tonn year total tonn notifi inform compet author draw programm test carri notifi order enabl compet author evalu risk substanc man environ test programm cover aspect strong reason contrari support evid chronic toxic studi carcinogen studi fertil studi gener studi effect fertil establish level teratolog studi rodent speci studi verifi teratolog studi level experi addit level studi effect embryo foetus establish acut acut toxic studi speci result level studi result biotransform studi studi pharmacokinet lead studi addit toxicokinet studi ecotoxicolog addit test accumul degrad mobil purpos studi determin accumul food chain bioaccumul studi special attent paid solubl substanc water octanol water partit coeffici result level accumul studi physiocochem properti lead larg scale flow test prolong toxic studi fish includ reproduct addit toxic studi acut acut bird quail accumul factor greater addit toxic studi organ prove absorpt desorpt studi substanc degrad annex ix provis relat child resist fasten record provis relat tactil warn danger record