commiss decis novemb aid itali plan implement industria farmaceutica cesar serono spa develop chemic synthesi process oral pharmaceut form polypeptid conjug substanc notifi document number italian text authent text eea relev ec commiss european commun regard treati establish european commun subparagraph articl thereof regard agreement european econom area articl thereof regard council regul ec call interest parti submit comment procedur letter regist receiv commiss march italian author notifi pursuant articl ec treati plan aid pharmaceut compani cesar serono spa if letter august octob commiss request addit inform notifi aid august letter august letter octob letter octob letter novemb letter italian author submit inform request letter sg date februari commiss inform itali decid initi procedur laid articl ec treati hereinaft quot decis initi procedur quot respect propos measur decis initi procedur publish offici journal european union commiss call interest parti submit comment prescrib period month pursuant articl regul ec commiss receiv comment if june letter june commiss forward if comment italian govern republ itali repli offici commiss letter februari june detail descript aid measur legal basi object measur legal basi aid legisl decre juli exist scheme approv commiss juli letter sg state aid object aid consist develop chemic synthesi process oral pharmaceut form polypeptid conjug substanc quot sviluppo di form farmaceutich orali ottenut da nuov molecol di natura sintetica polipeptidica sostanz coniug quot project enabl if strengthen posit tradit therapeut sector neurolog fertil time develop initi therapeut sector compani anti inflammatori anti cancer cardiolog project subdivid number detail stage quot step quot characteris specif scientif content step definit laboratori level process chemic synthesi small molecul polypeptid conjug substanc prepar activ ingredi destin preclin test step develop product process fraction destin clinic test phase step experiment verif valid semi quantit method prepar pharmaceut form stabil test clinic test step definit develop analyt method qualit quantit definit reaction intermediari activ ingredi degrad product contamin oral pharmaceut form step preclin test laboratori anim rodent dog toxicolog pharmacokinet step clinic test healthi patient phase evalu effect collater effect therapeut properti specif product studi mention quot step quot fall group molecul small molecul screen million molecul obtain foreign subsidiari if expect obtain quot hit quot turn lead identif quot lead quot compound protein activ ingredi drug applic laboratori guidonia montecelio glp good laboratori practic gmp good manag practic develop method chemic synthesi small molecul order obtain activ ingredi finish pharmaceut form suffici quantiti quot kiloscal quot subsequ preclin phase clinic test clinic test healthi patient target obtain molecul year end project lifetim unlik larg molecul small molecul capabl interf intracellular event insid cell protein block patholog adapt oral pharmaceut form resist gastrointestin ambient polypeptid polypeptid quot activ quot part protein liais cell receptor replac protein link project design develop chemic synthesi altern genet manipul conjug form exploit excel biotech field if creat synergi quot classic quot organ chemistri mix simpl molecul complex macromolecul conjug form combin activ ingredi inert chemic compound minimis product antibodi connect italian author present detail train project specif activ amp analyt techniqu qualiti secur standard link univers order carri amp project compani expand guidonia montecelio site rome build hous staff research technician administr personnel laboratori task devis procedur chemic synthesi molecul produc activ ingredi kiloscal quantiti defin pharmaceut form form aid propos aid provid form outright grant aid intens recipi elig cost aid recipi if part multin group serono sa headquart geneva serono sa largest biotech compani world turnov usd billion elig cost includ personnel overhead equip consult materi build cost relat preclin phase clinic test enter consult cost subcontract if site guidonia montecelio colleretto giacosa turin bourn hall cambridg tabl breakdown propos aid intens categori elig cost amount express eur million gt tabl gt italian author propos maximum intens allow industri develop precompetit amp activ train consid gener train mean articl commiss regul ec januari applic articl ec treati train aid qualif skill acquir laboratori transfer amp field allow intens line articl regul budget durat amp project cost eur expect year year expans laboratori year amp activ ground initi procedur decis initi procedur commiss approv aid measur notifi italian govern aspect doubt origin preclin test quot step quot point indent tabl classif industri research indirectli grant aid intens gge suffici justifi classif test research elig cost incent effect aid question decis initi procedur preclin test preced phase clinic test consist test activ principl anim speci increasingli close relat man hand preclin test protocol base seri experi number anim speci result collect critic analys check phase test launch view plan research critic investig qualifi industri research hand preclin test phase clinic test base quot prototyp quot version product albeit crude respect phase clinic test regard precompetit develop activ preced phase test conduct matur product closer market phase test commiss unabl rule possibl preclin test activ classifi closer market precompetit develop authoris prima faci aid intens gge propos italian author intens gge provid amp framework precompetit develop comment interest parti june if submit comment pursuant articl regul ec argu preclin test industri research mean amp framework central argument activ carri quot step quot necessarili reach subsequ quot step quot chemic synthesi activ principl optimis expect toxicolog effect evidenc molecul elimin surviv stage toxicolog preclin test total medicin chemistri discoveri laboratori subject quot lead optimist quot process chemic structur protein modifi order minim undesir toxic effect product mere molecul reach subsequ quot step quot phase clinic test test conduct laboratori anim common applic healthi human patient phase if consid preclin studi constitut quot critic investig aim acquisit knowledg object knowledg develop product process servic quot top if propos precis quantif consult cost preclin phase clinic test total invest cost amend hand if propos add cost item quot univers quot amount eur million state rank industri research precompetit develop assess legal aid italian author fulfil oblig pursuant articl treati notifi scheme commiss effect exist aid mean articl treati articl state quot aid grant member state state resourc form whatsoev distort threaten distort competit favour undertak product good affect trade member state incompat common market quot measur favour state resourc outright grant undertak larg multin if head multin group serono sa measur select scope regard econom activ carri recipi enterpris aid potenti distortionari effect condit competit affect trade member state mean articl assess aid light articl treati articl treati state quot consid compat common market aid facilit develop econom activ aid advers affect trade condit extent contrari common interest quot doubt express commiss concern amp aid assess made light commun framework state aid research develop indent annex framework defin industri research quot plan research critic investig aim acquisit knowledg object knowledg develop product process servic bring signific improv exist product process servic quot indent annex framework defin precompetit develop activ quot shape result industri research plan arrang design alter improv product process servic intend sold includ creation initi prototyp commerci includ conceptu formul design product process servic initi demonstr project pilot project provid project convert industri applic commerci exploit includ routin period made product product line manufactur process exist servic oper progress repres improv quot basi evid provid if view high rate unsuccess test develop phase preclin test commiss opinion activ consid technic certif prototyp valid conceptu formul product process initi demonstr project pilot project mean indent annex framework contrast commiss consid preclin test carri compani aim acquir knowledg prove essenti stage develop success rate appear line averag sector prove result obtain drug develop phase long product drug market commiss account high cost test present case preclin test consid industri research mean amp framework regard recalcul elig cost quantif consult cost addit cost item commiss factor consider present decis note italian author notifi chang measur allow pursuant articl treati conclus light forego observ commiss take view preclin test quot step quot measur notifi compli provis laid commun framework state aid research develop indent industri research benefit derog articl treati extent gge point framework adopt decis articl preclin test quot step quot project notifi republ itali develop chemic synthesi process oral pharmaceut form polypeptid conjug substanc constitut industri research mean commun framework state aid research develop fund extent gross grant equival aid exceed intens compat common market pursuant articl ec treati articl decis address republ itali brussel novemb commiss mario monti member commiss oj oj implement regul ministeri decre august oj oj oj