commiss direct ec septemb amend council direct eec includ chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl activ substanc text eea relev commiss european commun regard treati establish european commun regard council direct eec juli place plant protect product market articl thereof commiss regul eec decemb lai detail rule implement stage programm work refer articl council direct eec place plant protect product market establish list activ substanc assess view inclus annex direct eec list includ chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl activ substanc effect human health environ assess accord provis laid regul eec rang propos notifi commiss regul ec april lai activ substanc plant protect product design rapporteur member state implement regul eec rapporteur member state design turn submit relev assess report recommend commiss accord articl regul eec chlorothalonil rapporteur member state netherland relev inform submit januari chlorotoluron rapporteur member state spain relev inform submit cypermethrin rapporteur member state belgium relev inform submit octob daminozid rapporteur member state netherland relev inform submit juli thiophan methyl rapporteur member state germani relev inform submit novemb assess report review member state commiss stand committe food chain anim health review activ substanc finalis februari format commiss review report chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl review chlorothalonil chlorotoluron cypermethrin reveal open question address scientif committe plant european food safeti author efsa role review daminozid reveal number open question address efsa scientif panel plant health plant protect product residu ppr panel efsa ask comment mechan action carcinogen respons rodent dimethylhydrazid udmh threshold deriv effect request ppr panel regard submit question conclud basi data identifi mechan respons carcinogen action udmh rodent vitro evid genotox pure oxid protect udmh vivo studi addit ppr panel note appar discrep daminozid long term studi give rise carcinogen rat mice dose produc intern dose metabol form udmh order magnitud higher proven effect direct test addit methyl guanin found fold higher studi oral administr udmh rat compar data daminozid ppr panel consid conclus mechan carcinogen oral administ udmh regard includ degre uncertainti ppr panel conclud weight evid genotox mechan genotox mechan alter regul cell prolifer hormon imbal plausibl altern genotox mechan specif investig definit conclus mechan involv moment experiment test udmh carcinogen rat mice effect observ mg kg bw dai mg kg bw dai observ udmh carcinogen due genotox mechan dose consid toxicolog threshold take uncertainti mechan possibl udmh greenhous condit form oxidis deriv genotox ppr panel opinion dose threshold undertaken due caution opinion consider stand committe conclud daminozid accept condit review thiophan methyl reveal number open question address scientif committe plant scientif committe ask comment advis establish accept daili intak adi accept oper exposur level aoel regard result mutagen carcinogen reproduct studi benomyl carbendazim thiophan methyl committe note carbendazim biolog activ substanc common substanc benomyl thiophan methyl metabolis carbendazim substanc produc numer chromosom aberr aneuploidi mammalian cell expos vivo evid form damag genet materi induc substanc carcinogen concern effect fungicid reproduct explic interact microtubul spindl apparatu mechan aneuploidi induct understood consist inhibit polymeris tubulin protein essenti segreg chromosom cell divis involv interact dna multipl copi tubulin molecul present prolifer cell presenc low concentr fungicid limit number tubulin molecul affect toxicolog advers effect ensu clear advers effect level recognis adi aoel establish appear examin made plant protect product chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl expect satisfi gener requir laid articl direct eec regard examin detail commiss review report includ activ substanc annex order ensur member state authoris plant protect product activ substanc grant accord provis direct reason period allow elaps activ substanc includ annex order permit member state interest parti prepar meet requir result inclus prejudic oblig defin direct eec consequ includ activ substanc annex member state allow period month inclus review exist authoris plant protect product chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl ensur requir laid direct eec articl relev condit set annex satisfi member state vari replac withdraw exist authoris accord provis direct eec derog deadlin longer period provid submiss assess complet annex iii dossier plant protect product intend accord uniform principl laid direct eec experi gain previou inclus annex direct eec activ substanc assess framework regul eec shown difficulti aris interpret duti holder exist authoris relat access data order avoid difficulti appear clarifi duti member state duti verifi holder authoris demonstr access dossier satisfi requir annex ii direct clarif impos oblig member state holder authoris compar direct adopt amend annex amend direct eec measur provid direct accord opinion stand committe food chain anim health adopt direct articl annex direct eec amend set annex direct articl member state adopt publish august latest law regul administr provis compli direct forthwith commun commiss text provis correl tabl provis direct appli provis septemb member state adopt provis refer direct accompani refer occas offici public member state determin refer made articl member state accord direct eec amend withdraw exist authoris plant protect product chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl activ substanc august date verifi condit annex direct relat chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl met except identifi part entri activ substanc holder authoris access dossier satisfi requir annex ii direct accord condit articl direct derog paragraph authoris plant protect product chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl activ substanc activ substanc list annex direct eec februari latest member state evalu product accord uniform principl provid annex vi direct eec basi dossier satisfi requir annex iii direct take account part entri annex direct chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl basi evalu determin product satisfi condit set articl direct eec determin member state case product chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl activ substanc amend withdraw authoris februari latest case product chlorothalonil chlorotoluron cypermethrin daminozid thiophan methyl activ substanc amend withdraw authoris februari date fix amend withdraw respect direct direct ad relev substanc substanc annex direct eec whichev latest articl direct enter forc march articl direct address member state brussel septemb commiss marko kyprian member commiss oj direct amend regul ec european parliament council oj oj regul amend regul ec oj oj regul amend regul ec oj opinion scientif panel plant health plant protect product residu request commiss relat evalu daminozid context council direct eec efsa journal adopt opinion scientif committe plant scp benomi final scp carben final scp thiophan final march evalu benomyl carbendazim thiophan methyl context council direct eec place plant protect product market opinion adopt scientif committe plant march annex entri ad end tabl annex direct eec common identif number iupac puriti entri forc expir inclus specif provis quot chlorothalonilca cipac tetrachloroisophthalonitril kghexachlorobenzen kgdecachlorobiphenyl kg march februari part aonli fungicid authorisedpart bfor implement uniform principl annex vi conclus review report chlorothalonil appendic ii thereof finalis stand committe food chain anim health februari accountin assess member state pai attent protect aquat organ groundwat activ substanc metabolit sd substanc appli region vulner soil climat conditionscondit includ risk mitig measur chlorotoluron unstat stereochemistri ca cipac chloro tolyl dimethylurea kg march februari part aonli herbicid authorisedpart bfor implement uniform principl annex vi conclus review report chlorotoluron appendic ii thereof finalis stand committe food chain anim health februari account assess member state pai attent protect groundwat activ substanc appli region vulner soil climat condit condit authoris includ risk mitig measur cypermethrinca cipac rs cyano phenoxybenzyl rs ci tran dichlorovinyl dimethylcyclopropan carboxyl isom pair ci ci tran tran kg march februari part aonli insecticid authorisedpart bfor implement uniform principl annex vi conclus review report cypermethrin appendic ii thereof finalis stand committe food chain anim health februari account assessmentmemb state pai attent protect aquat organ bee target arthropod condit authoris includ risk mitig measur member state pai attent oper safeti condit authoris includ protect measur daminozideca cipac dimethylaminosuccinam acid kgimpur nitrosodimethylamin mg kg dimethylhydrazid mg kg march februari part aonli growth regul edibl crop authorisedpart bfor implement uniform principl annex vi conclus review report daminozid appendic ii thereof finalis stand committe food chain anim health februari account assess member state pai attent safeti oper worker entri condit authoris includ protect measur thiophan methyl unstat stereochemistri ca cipac dimethyl phenylen bi thioallophan kg march februari part aonli fungicid authorisedpart bfor implement uniform principl annex vi conclus review report thiophan methyl appendic ii thereof finalis stand committe food chain anim health februari account assess member state pai attent protect aquat organ earthworm soil macro organ condit authoris includ risk mitig measur quot detail ident specif activ substanc provid review report