council decis decemb establish commun reserv foot mouth diseas vaccin eec council european commun regard treati establish european econom commun regard council direct eec novemb introduc commun measur control foot mouth diseas amend decis eec articl thereof regard propos commiss januari member state discontinu routin vaccin foot mouth diseas territori view high densiti suscept speci part commun provid possibl emerg vaccin limit area circumst slaughter entir herd suffici elimin viru commun reserv foot mouth diseas vaccin establish base stock concentr inactiv antigen capabl quickli convert vaccin emerg antigen store separ locat facil formul bottl distribut provid criteria suppli storag antigen convers vaccin establish nation institut respons maintain reserv antigen cooper commun coordin institut foot mouth diseas vaccin design decis eec order ensur potenc safeti stabil antigen vaccin produc therefrom ensur quantiti type risk basi inform suppli refer laboratori identif foot mouth diseas viru design decis eec articl council decis eec june expenditur veterinari field amend decis eec establish commun reserv foot mouth diseas vaccin elig commun aid adopt decis articl establish commun reserv foot andmouth diseas vaccin consist suppli concentr inactiv antigen establish design member state storag reserv antigen refer indent guarante rapid formul bottl distribut establish design member state articl purpos decis definit appli antigen bank premis design articl storag commun reserv concentr inactiv antigen product foot mouth diseas vaccin commun coordin institut foot andmouth diseas vaccin cci institut design decis eec articl antigen bank establish institut anim health pirbright unit kingdom laboratoir de pathologi bovin du centr nation étude vétérinair alimentair lyon franc bayer ag cologn germani istituto zooprofilatico sperimental di brescia itali amount type antigen held antigen bank laid annex antigen distribut antigen bank ensur event technic problem result deterior antigen bank avail antigen vaccin product guarante antigen bank articl function duti antigen bank store commun reserv concentr inactiv foot mouth diseas viru antigen maintain us product safe potent vaccin emerg foot mouth diseas includ keep adequ record condit antigen store liais cci purpos check incom batch antigen stabil potenc safeti ii test batch store antigen stabil potenc safeti interv determin procedur laid articl opinion scientif veterinari committe iii advis replac antigen test potenc inadequ deliv concentr inactiv antigen establish design formul bottl distribut vaccin request commiss member state condit provid subparagraph articl direct eec member state countri vaccin articl establish suppli quantiti type antigen mention annex prejudic articl direct eec ensur formul product bottl distribut foot mouth diseas vaccin produc antigen design accord procedur laid articl decis purpos paragraph commiss issu call tender take account criteria technic requir suppli antigen accord annex ii suppli deliveri quantiti antigen bank form suitabl long term storag liquid nitrogen storag method recogn procedur laid articl obtain opinion scientif veterinari committe give equival stabil includ provis separ replic suitabl routin test guarante antigen suppli meet safeti stabil requir defin vaccin european pharmacopoeia requir potenc pd dose test vaccin reagent materi formul vaccin guarante vaccin suppli compli fulli european pharmacopoeia suppli vaccin time guarante rate deliveri bottl suitabl size label languag languag countri vaccin complianc establish suppli antigen minimum standard laboratori work foot mouth diseas viru vitro vivo european commiss control foot mouth diseas session rome april basi report expert act procedur laid articl quot cost suppli antigen provis servic articl antigen bank establish suppli antigen establish carri formul bottl oper strict condit hygien safeti accord gener accept standard good manufactur practic europ monitor cci articl detail arrang implement decis adopt procedur laid articl distribut antigen reserv antigen bank gener procedur replac antigen reserv rule decis eec invok make countri vaccin produc antigen replac accord indent derog obtain opinion stand veterinari committe figur pd dose laid articl vaccin articl commiss veterinari expert collabor compet author member state carri spot inspect verifi establish antigen bank oper accord decis commiss inform member state outcom inspect member state territori inspect carri provid expert assist requir accomplish task gener rule applic articl adopt accord procedur laid articl articl annex ii supplement amend accord procedur laid articl articl procedur laid articl chairman stand veterinari committe set decis eec hereinaft refer committe refer matter delai committe initi request repres member state repres commiss submit committe draft measur committe deliv opinion draft time limit chairman lai urgenc matter opinion deliv major laid articl treati case decis council requir adopt propos commiss vote repres member state committe weight manner set articl chairman vote commiss adopt measur envisag accord opinion committe measur envisag accord opinion committe opinion deliv commiss delai submit council propos relat measur council act qualifi major dai date referr council council act propos measur adopt commiss council decid measur simpl major articl council act qualifi major propos commiss review decis januari articl decis address member state brussel decemb council presid bukman oj oj page offici journal oj oj oj oj annex quantiti type antigen held antigen bank potent test vaccin strain european strain middl east strain european strain south american strain middl east strain european strain asia sat sat recent type strain argentina includ collect strain strain quantiti suffici provid million dose type dose observ potenc pd cattl test european pharmacopoeia annex ii technic requir suppli concentr inactiv monoval foot mouth diseas viru antigen formul vaccin avail concentr inactiv antigen suitabl storag liquid nitrogen method give equival stabil avail antigen type annex antigen suitabl prepar oil emuls vaccin pig case dose volum protect pig challeng intrapod inject id full inform provid test conduct produc seed viru cell materi product sampl master seed viru submit cci confirmatori test ident puriti sampl cell produc viru submit cci manufactur qualiti antigen consist gener accept standard good manufactur practic europ vaccin produc basi antigen compli requir european pharmacopoeia addit antigen inactiv concentr order inactiv batch antigen kinet inactiv document produc rang inactiv batch free infect viru safeti margin rang log base extrapol mixtur viru prepar inactiv transfer steril contain half inactiv time elaps manner prevent contamin equival method accept subsequ process antigen carri contamin environ fmd viru free polyethyleneglycol peg precipit polyethyleneoxid peo precipit ultrafiltr combin permit method concentr inactiv antigen perform innocu test inactiv antigen store seal contain quarantin area restrict high secur area concentr product inactiv antigen volum time formul convent vaccin produc number vaccin dose volum unit concentr materi main bulk inactiv antigen suppli contain suitabl storag liquid nitrogen divid volum agre produc cci consult supervis cci produc provid repres sampl mg concentr antigen period vitro vivo test produc provid relev inform antigen formul vaccin consider cci receipt batch concentr inactiv antigen check cci residu infect viru vitro cattl method prescrib vaccin european pharmacopoeia potenc vaccin prepar concentr antigen test cci vaccin formul prescript produc vaccin pig formul oil emuls cattl aluminium hydroxid saponin oil adjuv vaccin batch found unsatisfactori test immedi reconstitut deposit antigen bank reject replac produc expens cost test replac batch met produc compon concentr antigen interfer prepar stabil oil emuls vaccin antigen provid produc expect stabil year concentr qualiti vaccin adjuv agre cci produc expect shelf life product formul vaccin shelf life month vaccin exceed expiri date date check review cci formul vaccin cool temperatur condit european pharmacopoeia care maintain correct temperatur distribut administ