commiss direct ec amend council direct eec includ iprovalicarb prosulfuron sulfosulfuron activ substanc commiss european commun regard treati establish european commun regard council direct eec juli place plant protect product market amend commiss direct ec articl thereof accord articl direct eec ireland receiv march applic bayer ag inclus activ substanc iprovalicarb annex direct commiss decis ec confirm dossier quot complet quot sens consid satisfi principl data inform requir laid annex ii iii direct eec franc receiv similar applic novarti syngenta prosulfuron applic declar complet commiss decis ec ireland receiv similar applic april monsanto sulfosulfuron applic declar complet commiss decis ec activ substanc effect human health environ assess accord articl direct eec propos applic nomin rapporteur member state submit draft assess report substanc commiss novemb iprovalicarb januari prosulfuron april sulfosulfuron draft assess report review member state commiss stand committe food chain anim health review finalis februari format commiss review report iprovalicarb prosulfuron sulfosulfuron dossier inform review submit scientif committe plant iprovalicarb committe ask comment accept risk metabolit pmpa earthworm relev human tumour observ rat lifetim exposur high dose opinion committe identifi data earthworm subsequ provid assess conclud effect observ rat suffici safeti margin exist ensur protect consum oper observ scientif committe consider formul direct relev review report respect prosulfuron committe ask comment accept risk breakdown product activ substanc sediment dwell organ hormon disrupt effect observ test anim opinion committe conclud uterin mammari observ rat lifetim exposur consid relev human risk assess prosulfuron context intend committe comment risk breakdown product sediment dwell speci adequ assess note persist metabolit form signific quantiti sediment water test assess pend inform assess subsequ provid observ scientif committe consider formul direct relev review report respect sulfosulfuron committe ask opinion occurr bladder tumour month mous studi establish acut refer dose sulfosulfuron confirm lethal studi earthworm unnecessari notwithstand persist soil metabolit opinion committe consid lesion observ mice predict carcinogen hazard human establish acut refer dose conclud signific long term risk earthworm aris committe highlight assess potenti environment impact unidentifi metabolit inform subsequ provid request assess made appear examin made plant protect product activ substanc concern expect satisfi gener requir laid articl articl direct eec regard examin detail commiss review report includ activ substanc annex order ensur member state authoris plant protect product activ substanc concern grant accord provis direct commiss review report requir proper implement member state section uniform principl laid direct eec provid finalis review report confidenti inform made member state consult interest parti inclus member state allow reason period implement provis direct eec plant protect product iprovalicarb prosulfuron sulfosulfuron review exist provision authoris end period latest transform authoris full authoris amend withdraw accord provis direct eec amend direct eec measur provid direct accord opinion stand committe food chain anim health adopt direct articl annex direct eec amend set annex direct articl member state review report iprovalicarb prosulfuron sulfosulfuron confidenti inform mean articl direct eec consult interest parti make specif request articl member state adopt publish decemb latest law regul administr provis compli direct forthwith inform commiss thereof appli provis januari member state adopt provis refer direct accompani refer occas offici public member state determin refer made articl member state review authoris plant protect product iprovalicarb prosulfuron sulfosulfuron ensur condit relat activ substanc set annex direct eec compli amend withdraw authoris accord direct eec decemb member state authoris plant protect product iprovalicarb prosulfuron sulfosulfuron activ substanc activ substanc list annex direct eec juli evalu product accord uniform principl provid annex vi direct eec basi dossier satisfi requir annex iii thereto basi evalu determin product satisfi condit set articl direct eec decemb latest amend withdraw authoris plant protect product articl direct enter forc juli articl direct address member state brussel commiss david byrn member commiss oj oj oj oj oj opinion scientif committe plant evalu iprovalicarb context direct eec place plant protect product market adopt march opinion scientif committe plant addit question commiss evalu iprovalicarb szx context direct eec adopt novemb opinion scientif committe plant inclus prosulfuron cga annex direct eec place plant protect product market scp prosulf final june opinion scientif committe plant evalu mon sulfosulfuron context direct eec place plant protect product market scp sulfo final date decemb annex annex row ad end tabl quot quot detail ident specif activ substanc provid review report