commiss regul ec octob amend regul ec continu substanc list annex ii text eea relev commiss european commun regard treati establish european commun regard council direct eec juli place plant protect product market fourth subparagraph articl thereof commiss regul ec novemb extend time period refer articl council direct eec inclus activ substanc annex direct withdraw authoris plant protect product substanc temporari measur enabl develop altern addit technic evid provid demonstr essenti activ substanc absenc effici altern franc present evid demonstr essenti inform evalu commiss member state expert derog case justifi give rise concern restrict control harm organ effici altern exist regul ec amend measur provid regul accord opinion stand committe food chain anim health adopt regul articl annex ii regul ec line activ substanc cpa chlorophenoxyacet acid replac gt tabl gt articl regul enter forc seventh dai public offici journal european union regul bind entireti directli applic member state brussel octob commiss david byrn member commiss oj direct amend commiss direct ec oj oj regul amend regul ec oj