commiss direct eec juli amend council direct eec place plant protect product market commiss european commun regard treati establish european econom commun regard council direct eec juli place plant protect product market articl thereof annex ii iii direct eec lai requir dossier submit applic inclus activ substanc annex author plant protect product applic annex ii iii precis detail requir inform circumst condit technic protocol data gener provis introduc order permit applic prepar dossier greater precis present time gener introductionari provis annex ii iii data requir efficaci test provid section part annex iii introduct annex ii iii refer applic principl good laboratori practic glp data requir applic principl consid efficaci test test physico chemic properti inform relat data properti safeti respect human anim health environ provid temporari exempt applic principl data requir permit laboratori concern adapt requir glp specif european mediterranean plant protect organ eppo guidelin constitut time basi set minimum requir appli member state regard guidelin efficaci test appear proce urgent detail examin guidelin provid higher standard direct eec case guidelin inadequ efficaci test measur provid direct accord opinion stand committe plant health adopt direct articl direct eec amend section head introduct annex ii replac annex hereto section head introduct annex iii replac annex ii hereto section head efficaci data part annex iii replac annex iii hereto articl member state bring forc law regul administr provis compli direct twelv month notif thereof immedi inform commiss thereof member state adopt measur refer direct accompani refer time offici public procedur refer adopt member state articl direct address member state brussel juli commiss rené steichen member commiss oj annex introduct inform requir includ technic dossier suppli inform evalu forese risk delai substanc entail human anim environ inform result studi refer relev gener test guidelin refer annex case studi initi adopt modif annex inform gener suitabl internation nation valid test guidelin absenc thereof test guidelin accept compet author event test guidelin inappropri refer annex inlcud justif accept compet author guidelin includ requir compet author full descript test guidelin refer annex full descript deviat includ justif accept compet author deviat includ full unbias report studi conduct full descript justif accept compet author data inform ow natur product propos provid scientif technic suppli inform data relev gener accord requir direct eec test analys conduct accord principl laid direct eec test obtain data properti safeti respect human anim health environ derog point test analys obtain data properti safeti respect honeybe benefici arthropod bee conduct offici offici recogn test facil organ satisfi requir set point introduct annex iii derog expir decemb oj annex ii introduct inform requir includ technic dossier suppli inform evalu efficaci forese risk delai plant protect product entail human anim environ inform result studi refer relev gener test guidelin refer annex case studi initi adopt modif annex inform gener suitabl internation nation valid test guidelin absenc thereof test guidelin accept compet author event test guidelin inappropri refer annex includ justif accept compet author guidelin includ requir compet author full descript test guidelin refer annex full descript deviat includ justif accept compet author deviat includ full unbias report studi conduct full descript justif accept compet author data inform ow natur product propos provid scientif technic suppli inform data relev gener accord requir direct eec test analys conduct accord principl laid direct eec test obtain data properti safeti respect human anim health environ test analys requir provis section point annex conduct offici offici recogn test facilit organ satisfi requir dispos suffici scientif technic staff educ train technic knowledg experi assign function dispos suitabl item equip requir correct perform test measur claim compet carri equip properli maintain calibr put servic establish programm dispos experiment field glasshous growth cabinet storag room environ test undertaken invalid result advers effect requir accuraci measur make relev personnel oper procedur protocol trial make request compet author prior commenc test detail inform locat plant protect product includ ensur qualiti work perform type rang volum intend purpos calibr record final test report long product concern author commun member state requir offici recogn test facil organ request offici facil organ report relev nation author detail inform demonstr satisfi requir provid point accept time inspect member state regularli organ territori order verifi complianc requir laid point derog point provis point appli decemb test analys obtain data properti safeti respect honeybe benefici arthropod bee inform requir includ propos classif label plant protect product accord relev commun direct individi case requir inform provid annex ii part formul inform requir studi perform inform formul made compet author consid formul permit food anim feed stuff medicin cosmet accord commun legisl safeti data sheet submit formul accord council direct eec annex iii efficaci data gener data suppli suffici permit evalu plant protect product made evalu natur extent benefit accru prepar exist comparison suitabl refer product damag threshold defin condit number trial conduct report depend factor extent properti actiev substanc rang condit aris includ variabl plant health condit climat differ rang agriculr practic uniform crop mode applic type harm organ type plant protect product suffici data gener submit confirm pattern determin hold region rang condit encount region concern recommend applic claim test propos region unnecessari condit compar region test carri applic substanti claim compar documentari evid order assess season differ suffici data gener submit confirm perform plant protect product agronom climat region crop commod harm organ combin trial effect phytotox relev grow season report opinion applic trial season adequ confirm valid claim made basi extrapol result crop commod situat test close similar prepar justif accept compet author carri seaon work provid convers climat plant health condit reason data obtain season limit assess perform trial season conduct report preliminari test report summari form preliminari test includ glasshous field studi assess biolog activ dose rang find plant protect product activ substanc submit request compet author report provid addit inform compet author evalu plant product product inform submit justif accept compet author provid test effect aim test test provid suffici data permit evalu level durat consist control protect intend effect plant protect product comparison suitabl refer product exist test condit trial consist compon test product refer product untreat control perform plant protect product investig relat suitabl refer product exist suitabl refer product defin author plant protect product prove suffici perform practic agricultur plant health environment includ climat condit area propos gener formul type effect harm organ work spectrum method applic close test plant protect product plant protect product test circumst target harm organ shown present level caus advers effect yield qualiti oper benefit unprotect crop area plant plant product treat harm organ present level evalu plant protect product made trial provid data plant protect product control harm organ show level control speci harm organ concern speci repres group claim made trial includ stage growth life cycl harm speci relev strain race show degre suscept similarli trial provid data plant protect product plant growth regul level effect speci treat includ investig differ respons repres sampl rang cultivar propos order clarifi dose respons dose rate lower recommend includ trial order enabl assess recommend rate minimum achiev desir effect durat effect treatment investig relat control target organ effect treat plant plant product applic recommend trial report establish durat effect applic number applic desir interv evid submit show dose time medthod applic recommend give adequ control protect intend effect rang circumst encount practic clear indic perform plant protect product affect signific degre environement factor temperatur rain investig effect factor performac carri report perform chemic relat product os affect propos label claim includ recommend plant protect product plant protect product adjuv inform perform mixtur provid test guidelin trial design investig issu minim effect random variat part site enabl statist analysi appli result amen analysi design analysi report trial accord european mediterranean plant protect organ eppo guidelin report includ detail critic assess data trial carri accord specif eppo guidelin requir test carri territori guidelin satisfi requir eppo guidelin statist analysi result amen analysi carri test guidelin adapt enabl analysi inform occurr occurr develop resist laboratori data exist field inform relat occurr develop resist cross resist popul harm organ activ substanc relat activ substanc provid inform directli relev author renew speci harm organ crop provid provid indic likelihood resist develop target popul evid inform suggest commerci develop resist evid gener submit sensit popul harm organ concern plant protect product case manag strategi design minim likelihood resist cross resist develop target speci provid effect yield treat plant plant product term quantiti qualiti effect qualiti plant plant product aim test test provid suffici data permit evalu occurr taint odour qualiti aspect plant plant product treatment plant protect product circumst requir possibl occurr taint odour food crop investig report natur product risk occurr taint odour expect product base close similar activ ingredi shown present risk occurr taint odour effect plant protect product qualiti aspect treat plant plant product investig report natur plant protect product advers influenc qualiti aspect case plant growth regul close harvest product base close similar activ ingredi shown advers influenc qualiti test conduct initi main crop plant protect product normal rate applic relev main method process effect observ perform test normal rate applic extent investig crop depend degre similar main crop test quantiti qualiti data main crop manner plant protect product method process crop similar gener suffici perform test main formul type author effect transform process aim test test provid suffici data permit evalu occurr advers effect treatment plant protect product transform process qualiti product circumst requir treat plant plant product intend transform process wine make brew bread make harvest signific residu present possibl occurr advers effect investig report indic plant protect product influenc process involv case plant growth regul fungicid close harvest product base close similar activ ingredi shown advers influenc process product gener suffici perform test main formul type author effect yield treat plant plant product aim test test provid suffici data permit evalu perform plant protect product occurr yield reduct loss storag treat plant plant product circumst requir effect plant protect product yield yield compon treat plant product determin relev treat plant plant product store effect yield storag includ data starag life determin relev inform test requir provis point phytotox target plant includ cultivar target plant product aim test test provid suffici data permit evalu perform plant protect product occurr phytotox treatment plant protect product circumst requir herbicid plant protect product advers effect transitori trial perform accord point margin select target crop establish recommend rate applic phytotox effect intermedi applic rate investig advers effect occur claim unimport comparison benefit transient evid support claim requir yield measur submit safeti plant protect product main cultivar main crop recommend demonstr includ effect crop growh stage vigour factor influenc suspect damag injuri extent investig crop depend degre similar main crop test quantiti qualiti data main crop manner plant protect product relev similar gener suffici perform test main formul type author propos label claim includ recommend plant protect product plant protect product provis previou paragraph appli mixtur test guidelin observ phytotox perform test provid point phytotox effect accur assess record accord eppo guidelin member state requir test carri territori member state guidelin satisfi requir eppo guidelin statist analysi result amen analysi carri test guidelin adapt enabl analysi observ undesir unintend side effect benefici target organ succeed crop plant part treat plant propag purpos seed cut runner impact succeed crop aim inform requir suffici data report permit evalu advers effect treatment plant protect product succeed crop circumst requir data gener accord section point show signif residu activ substanc metabolit degrad product biolog activ succeed crop remain soil plant materi straw organ materi sow plant time succeed crop observ submit effect normal rang succeed crop impact plant includ adjac crop aim inform requir suffici data report permit evalu advers effect treatment plant protect product plant includ adjac crop circumst requir observ submit advers effect plant includ normal rang adjac crop indic plant protect product affect plant vapour drift impact treat plant plant product propag aim inform requir suffici data report permit evalu advers effect treatment plant protect product plant plant product ot propag circumst requir observ submit impact plant protect product plant part propag propos preclud crop intend product seed cut runner tuber plant seed viabil germin vigour ii cut root growth rate iii runner establish growth rate iv tuber sprout normal growth test guidelin seed test ista method effect benefici target organ effect posit neg incid harm organ observ test perform accord requir section report observ environment effect report effect wildlif benefici organ summari evalu data present summari data inform provid point provid detail critic assess data refer benefit plant protect product offer advers effect aris measur avoid minim advers effect intern rule seed test proceed intern seed test associ seed scienc technolog volum