council regul eec march evalu control risk exist substanc council european commun regard treati establish european econom commun articl thereof regard propos commiss cooper european parliament regard opinion econom social committe dispar law regul administr provis relat risk evalu exist substanc effect prepar member state liabl hinder trade member state creat unequ condit competit measur approxim provis member state object establish function intern market concern health safeti environment consum protect high level protect basi order ensur protect man includ worker consum environ carri commun level systemat evalu risk involv exist substanc appear einec european inventori exist commerci substanc interest effici economi establish commun polici ensur share coordin respons member state commiss industrialist regul legal instrument impos directli manufactur import precis requir implement time manner commun order undertak preliminari risk evalu exist substanc identifi prioriti substanc requir attent collect inform test data exist substanc requir provid inform appli substanc basi intrins properti involv risk gener recogn minim inform submit manufactur import commiss send copi member state member state manufactur import establish territori submit inform time compet author purpos risk evalu exist substanc case requir manufactur import submit data carri test exist substanc draw commun level list prioriti substanc requir special attent commiss submit year entri forc regul initi prioriti list risk evalu substanc prioriti list carri member state design commun level basi distribut respons take account situat member state risk evalu principl establish commun level prioriti set process risk evalu exist substanc account lack data effect substanc work carri intern organ organ econom cooper develop legisl commun programm danger substanc adopt commun level result risk evalu recommend strategi limit risk respect substanc prioriti list reduc minimum number anim experiment purpos accord provis council direct eec novemb approxim law regul administr provis member state protect anim experiment scientif purpos consult european centr altern test method anim avoid recours valid altern procedur test chemic substanc carri context regul follow good laboratori practic set council direct eec decemb harmon law regul administr provis relat applic principl good laboratori practic verif applic test chemic substanc commiss assist committe made repres member state power adapt annex technic progress adopt implement measur respect regul confidenti natur inform cover industri commerci secreci guarante adopt regul articl aim scope regul appli collect circul access inform exist substanc evalu risk exist substanc man includ worker consum environ order ensur manag risk framework commun provis provis regul appli prejudic commun legisl protect worker consum articl definit purpos regul substanc mean chemic element compound natur state obtain product process includ addit preserv stabil product impur deriv process exclud solvent separ affect stabil substanc chang composit prepar mean mixtur solut compos substanc import mean bring custom territori commun produc mean product substanc isol solid liquid gaseou form exist substanc mean substanc list einec part systemat data report establish list prioriti substanc articl data report high volum product import exist substanc prejudic articl manufactur produc import import exist substanc prepar quantiti exceed tonn year year preced adopt regul year adopt submit commiss accord procedur laid articl inform annex iii month entri forc regul case substanc appear annex month case substanc appear einec annex einec number substanc quantiti substanc produc import classif substanc annex council direct eec june approxim law regul administr provis member state relat classif packag label danger substanc provision classif direct includ class danger danger symbol risk phrase safeti phrase inform forese substanc data physico chemic properti substanc data pathwai environment fate data ecotox substanc data acut subacut toxic substanc data carcinogen mutagen toxic reproduct substanc indic relev risk evalu substanc manufactur import make reason effort obtain exist data point absenc inform manufactur import bound carri test anim order submit data articl data report lower volum product import exist substanc prejudic articl manufactur produc import import exist substanc prepar quantiti exceed tonn year greater tonn year year preced adopt regul year adopt submit commiss accord procedur laid articl inform annex iv period month start regul forc year substanc einec number quantiti substanc produc import classif substanc annex direct eec provision classif direct includ class danger danger symbol risk phrase safeti phrase inform forese substanc commiss consult member state determin case request manufactur import substanc declar pursuanc paragraph submit addit inform framework annex iii physico chemic properti toxic ecotox substanc exposur aspect relev risk evalu substanc prejudic articl manufactur import bound carri test anim purpos specif inform submit procedur submiss determin accord procedur laid articl articl exempt substanc list annex ii exempt provis articl inform substanc list annex ii request procedur laid accord procedur refer articl articl procedur data report case substanc produc import manufactur import inform refer articl articl submit manufactur import act agreement behalf manufactur import concern submit commiss inform point data set laid annex iii make refer data set submit manufactur import submit inform refer articl articl manufactur import special softwar packag diskett made free charg commiss member state provid manufactur import establish territori requir submit simultan compet author inform forward commiss pursuant articl receipt data refer articl commiss forward copi member state articl updat report inform oblig submit inform spontan manufactur import submit inform substanc accord articl updat inform forward commiss submit substanc substanti chang type form magnitud durat exposur man environ substanc data obtain physico chemic properti toxicolog ecotoxicolog effect relev evalu potenti risk present substanc chang provision classif direct eec requir updat inform product import volum refer articl year chang relat volum annex iii annex iv manufactur import exist substanc acquir knowledg support conclus substanc question present risk man environ immedi report inform commiss member state locat receipt data refer paragraph commiss submit copi thereof member state articl prioriti list basi inform submit manufactur import accord articl basi nation list prioriti substanc commiss consult member state regularli draw list prioriti substanc group substanc hereinaft refer prioriti list requir attent potenti effect man environ list adopt accord procedur laid articl publish commiss time year entri forc regul factor account draw prioriti list effect substanc man environ exposur man environ substanc lack data effect substanc man environ work carri intern fora commun legisl programm relat danger substanc substanc subject evalu commun legisl prioriti list evalu fail cover risk environ risk man includ worker consum risk adequ evalu equival evalu carri commun legisl repeat regul special attent substanc chronic effect substanc suspect carcinogen toxic reproduct mutagen suspect increas incid effect articl data suppli substanc appear prioriti list substanc includ prioriti list refer articl manufactur import submit inform substanc accord articl month public list submit rapporteur design accord articl relev inform studi report risk assess substanc concern addit requir paragraph prejudic test requir articl particular list annex vii direct eec prioriti substanc manufactur import submit inform substanc accord articl oblig carri test obtain miss data provid test result test report rapporteur month derog paragraph manufactur import request rapporteur exempt addit test ground piec inform unnecessari risk assess imposs obtain request longer period circumst requir full justif provid support derog rapporteur decid request accept derog allow conform articl rapporteur immedi inform commiss decis commiss inform member state decis rapporteur contest member state final decis conform committe procedur laid articl part risk evalu articl risk evalu substanc prioriti list level member state design rapporteur substanc prioriti list member state respons evalu accord procedur laid articl whilst ensur fair burden share member state member state design rapporteur substanc compet author refer articl rapporteur respons evalu inform submit manufactur import conform requir articl inform identifi consult produc import concern purpos risk evalu requir manufactur import prioriti substanc submit inform carri test rapporteur consid request inform test inform commiss decis impos import manufactur request inform test time limit respond request accord procedur laid articl rapporteur prioriti substanc evalu risk substanc man environ suggest strategi limit risk includ control measur surveil programm control measur includ recommend restrict market substanc question rapporteur submit analysi advantag drawback substanc avail replac substanc recommend risk evalu strategi forward commiss rapporteur real potenti risk man environ assess basi principl adopt june accord procedur laid articl pincipl regularli review revis accord procedur manufactur import ask inform test check view limit practic experi vertebr inform need evalu substanc manufactur import declar substanc obtain possibl payment cost experi essenti check test anim replac limit method laboratori test perform due respect principl good laboratori practic laid direct eec provis direct eec articl risk evalu substanc prioriti list commun level basi risk evalu measur recommend rapporteur commiss submit committe refer articl propos result risk evalu prioriti substanc recommend strategi limit risk result risk evalu prioriti substanc recommend strategi adopt commun level accord procedur laid articl publish commiss basi risk evalu recommend strategi refer paragraph commiss decid propos commun measur framework council direct eec juli approxim law regul administr provis member state relat restrict market danger substanc prepar framework relev exist commun instrument articl oblig relat provis inform test manufactur import substanc appear prioriti list refer articl submit inform articl time limit suppli rapporteur data test result substanc refer articl refer articl prejudic articl valid reason believ substanc appear einec present risk man environ decis manufactur import substanc suppli inform possess subject exist substanc test provid report thereon accord procedur laid articl case substanc produc import prepar manufactur import test pursuanc paragraph perform manufactur import act behalf manufactur import concern manufactur import concern make refer test carri manufactur import make fair equit contribut cost articl collabor member state commiss member state design compet author particip implement regul collabor commiss work refer articl member state design author author commiss send copi data receiv part manag confidenti miscellan final provis articl amend adapt annex amend adapt annex ii iii iv technic progress adopt accord procedur laid articl amend adapt annex adopt commiss articl committe commiss assist committe compos repres member state chair repres commiss repres commiss submit committe draft measur committe deliv opinion draft time limit chairman lai urgenc matter opinion deliv major laid articl treati case decis council requir adopt propos commiss vote repres member state committe weight manner set articl chairman vote commiss adopt measur envisag accord opinion committe measur envisag accord opinion committe opinion deliv commiss delai submit council propos relat measur council act qualifi major case refer subparagraph expiri period month date referr council council act propos measur adopt commiss case decis refer articl articl expiri period month date referr council council act propos measur adopt commiss save council decid measur simpl major articl confidenti data consid confidenti problem manufactur import inform provid articl consid commerci sensit disclosur harm industri commerci wish secret person member state commiss full justif case industri commerci secreci appli substanc einec manufactur import data physico chemic properti substanc pathwai environment fate summari result toxicolog ecotoxicolog test data carcinogen mutagen substanc toxic reproduct inform relat method precaut relat substanc emerg measur inform withheld lead anim experi carri repeat needlessli analyt method make detect danger substanc discharg environ determin direct exposur human substanc manufactur import disclos previous confidenti inform inform compet author author receiv inform decid respons inform cover industri commerci secreci accord paragraph inform accept confidenti author receiv inform treat confidenti author articl year adopt regul member state establish legal administr measur order deal complianc provis regul articl regul enter forc dai public offici journal european commun regul bind entireti directli applic member state brussel march council presid auken oj oj oj oj oj oj oj oj direct amend commiss direct eec oj oj direct amend direct eec oj annex list exist substanc produc import commun quantiti exceed tonn year petroleum product group group identifi number number letter group group group group group group group page group substanc manufactur import decid submit set inform point inclus inform laid annex iii concern inform appli substanc contain group annex ii list substanc exempt provis articl annex iii inform refer articl gener inform substanc einec ca synonym puriti impur molecular formula structur formula type substanc physic state submit data set quantiti produc import greater tonn year substanc produc month substanc import month classif label pattern complet data set submit manufactur import act behalf concern manufactur import remark option dispos physic chemic data melt point boil point densiti vapour pressur partit coeffici log pow water solubl flash point auto flammabl flammabl explos properti oxid properti data remark environment fate pathwai stabil photodegrad stabil water stabil soil monitor data environ transport distribut environment compart includ estim environment concentr distribut pathwai transport distribut environment compart biodegrad bioaccumul remark ecotox toxic fish toxic daphnia aquat invertebr toxic alga toxic bacteria toxic terrestri organ toxic soil dwell organ remark toxic acut toxic acut oral toxic acut inhal toxic acut dermal toxic acut toxic rout administr corros irrit skin irrit ey irrit sensit repeat dose toxic genet toxic vitro genet toxic vivo carcinogen toxic reproduct relev inform experi human exposur list refer annex iv inform refer articl gener inform substanc einec ca synonym puriti impur molecular formula structur formula type substanc physic state submit data set quantiti produc import exceed tonn year greater tonn substanc produc month substanc import month classif label pattern remark annex commun inform offic special softwar packag diskett inform offic commun germani bonn kommiss der europaeischen gemeinschaften vertretung der bundesrepublik deutschland zitelmannstrass bonn telex europ telefax berlin kommiss der europaeischen gemeinschaften vertretung der bundesrepublik deutschland aussenstel berlin kurfuerstendamm berlin telex europ telefax munich kommiss der europaeischen gemeinschaften vertretung der bundesrepublik deutschland vertretung muenchen erhardtstrass muenchen telex telefax belgium brussel commiss de communauté européenn bureau en belgiqu commissi van de europes gemeenschappen bureau belgië rue archimed bruxel archimedesstraat brussel telex comtnf telefax denmark copenhagen kommissionen de europaeisk faellesskab kontor danmark hoejbrohu oestergad postbox dk koebenhavn telex comeur dk telefax spain madrid comisión de la comunidad europea oficina en españa call de serrano planta madrid telex oip telefax barcelona edificio atlantico av diagon bi planta barcelona telefax franc pari commiss de communauté européenn bureau de représent en franc bld st germain pari telex pari comeur telefax marseil commiss de communauté européenn bureau marseil cmci rue henri barbuss marseil cedex telex eurma telefax greec athen epitropi ton evropaikon koinotiton grafeio stin ellada vassilissi sofia case postal gr athina telex ecat gr telefax ireland dublin commiss european commun offic ireland molesworth street irl dublin telex euco ei telefax itali roma commission dell comunità europe ufficio italia poli roma telex euroma telefax milan commission dell comunità europe ufficio milano corso magenta milano telex eurmil telefax luxembourg luxembourg commiss de communauté européenn bureau au luxembourg bâtiment jean monnet rue alcid de gasperi luxembourg telex comeur lu telefax netherland hagu commissi van de europes gemeenschappen bureau nederland kort vijverberg nl ab den haag telex eurco nl telefax portug lisbon comissao da comunidad europeia gabinet em portug centro europeu jean monnet largo jean monnet lisboa telex comeur telefax unit kingdom london commiss european commun offic unit kingdom jean monnet hous storei gate uk london sw telex euruk telefax belfast commiss european commun offic northern ireland windsor hous bedford street uk belfast bt telex cecbel telefax cardiff commiss european commun offic wale cathedr road po box uk cardiff cf sg telex europa telefax edinburgh commiss european commun offic scotland alva street uk edinburgh eh ph telex eued telefax