well, always play something funny rather than realistic, most people judge based on comedy value (in my experience anyway).
we all know the feeling, there lies a face up wild, take it or not? if it is early in the game, it is almost never a smart play to take it, you will most likely use every color at some point, and thus any two cards are better than one, even if it is wild. late in the game when time and remaining trains are concerns, sometimes taking the wild is a good play.
1) is a route ‘key’? how long will a detour take you?
2) is the route colored or wild? 