Dr. Richard Kimble, a prominent Chicago vascular surgeon, arrives home to find his wife Helen killed by a prosthetic man, struggling with the killer who escapes. The lack of evidence, Helen's valued life insurance, and a misunderstood 911 call result in Kimble's conviction of first-degree murder. Being bused to death row at Menard Correctional Center, fellow prisoners attempt an escape that sends the bus down onto an oncoming train. Kimble escapes and flees. Deputy U.S. Marshal Samuel Gerard and partners Renfro, Biggs, Newman and Poole arrive at the crash site, searching for Kimble. Kimble sneaks into a hospital to treat his wounds and alter his appearance. He eludes the authorities, but Gerard corners him at a storm drain edge at a dam as he jumps into the water below.




Chicago, Illinois, where the story takes place.
Kimble returns to Chicago to hunt for the murderer and acquires money from his friend and colleague Dr. Charles Nichols. Posing as a janitor, Kimble enters the county hospital's prosthetic department and obtains a list of people who had their prosthesis replaced after his wife's murder. Following a police lead confirming Kimble's whereabouts, Gerard speculates Kimble is searching for the killer.
Kimble breaks into the residence of Fredrick Sykes, one on the list, discovering him the murderer, employed by pharmaceutical company Devlin MacGregor who is to release a new drug called Provasic. Kimble previously discovered that it caused liver damage, preventing FDA approval. He later deduces that Nichols, the development leader, arranged a cover-up and ordered Sykes to kill him: His wife's death was incidental. Gerard follows Kimble's lead to Sykes' home and reaches the same conclusion.
As Kimble takes an elevated train to confront Nichols at the drug's presentation in a hotel, Sykes attacks him. In the struggle, Sykes shoots a transit cop before being subdued and handcuffed to a pole. Kimble arrives at the conference and interrupts Nichols's speech, accusing him of falsifying his medical research and orchestrating his wife's murder. They fight while being chased throughout by US Marshals and the Chicago Police Department. Gerard calls out to Kimble that he knows about Nichols' conspiracy. Nichols knocks out Renfro and takes his gun but Kimble knocks him out as he is about to shoot Gerard. Kimble surrenders to Gerard, who escorts him out of the hotel. Nichols and Sykes are arrested. Kimble is exonerated and driven away from the crime scene by Gerard.
What is the name of the new drug employed by pharmaceutical company?
Provasic