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Rose and her boyfriend Hart get into a motorcycle accident within the Quebec countryside, caused by a family inside a camper van stopping them in the middle of the road to argue for directions, and are sent to the nearby Keloid Clinc for Plastic Surgery called by a nearby patient witnessing the accident. While Hart suffers a broken hand, a separated shoulder and a concussion, Rose is more severely injured by the incident. At the clinic, Murray Cypher pitches a promising franchising deal to Dr. Dan Keloid and his wife Roxanne, but Keloid remains unconvinced. Just then, Dr. Keloid sees and recognizes that Rose needs immediate surgery and decides to perform a radical procedure on her, one which uses morphogenetically neutral grafts to her chest and abdomen in the hope that it will differentiate and replace the damaged skin and organs.
Hart is released, but Rose still remains in a coma. One night, Rose awakens and screams while pulling out her I.V. tube, awakening patient Lloyd Walsh to calm her down and hold her hand; Rose causes a sort of vague injury to him as she holds him. When being checked, Lloyd cannot remember anything afterwards, and the doctor doesn't know what caused his injury to his right arm. It is only known that his blood isn't clotting from the wound and cannot fell anything on his right side; Dr. Keloid thinks that it might have been a mild stroke and transfers him to Montreal General Hospital for further evaluation. Meanwhile, Rose leaves the clinic periodically to feed; her experimental procedures have caused a wild mutation in her body, and only she can subsist on human blood. To attain it, a bizarre new organ has developed in Rose's armpit; she hides a red phallic stinger emerged from a small sphincter orifice, which can pierce her victims and draw their blood. After vomiting from drinking a cow's blood, she feeds on a drunken farmer which turns him into a pale zombie-esque monster and attacks a waitress at a nearby diner before being subdued. The next night, Rose then attacks a young nurse in a hot tub and hides her unconscious body inside a freezer.
The next day, Lloyd discharges himself from the clinic and hails a taxi to take him to the airport. During the trip, Lloyd turns infected and bites the driver's neck, making him crash into the freeway and gets totaled by a truck. At the clinic, Dr. Keloid examines an unconscious Rose and notices the orifice, but Rose awakens and strikes his hand with the stinger. Rose calls Hart for her aid, in which he calls Murray Cypher to come with him. Dr. Keolid goes into the O.R. to operate on a patient, but he turns infected when he foams from his mouth and feasts on a nurse. Soon, the orderlies attack the vicious Dr. Keolid as Rose successfully escapes from the clinic. She hitches a ride to Montreal from a passing truck driver, and feeds on the driver after she vomits from eating food. She then hitches a ride with another car driver, and the unconscious truck driver awakens before going to a depot and attacking his colleagues. At the police station, chief Claude LePointe, meets with Hart, Murray and a few public health officials with talks of an upcoming epidemic. While they watch reports of the attacks, an officer whom was infected by Dr. Keloid, foams at his moth and attacks Hart before being shot by the un-infected officers. To prevent the infection from progressing, everyone including Hart and Murray are to be held at the station for 48 hours. After Hart calls Rose's best friend Mindy Kent to keep Rose in her apartment until he can come over, Rose arrives in the city and asks her to stay in her apartment for a few days. After Mindy watches a broadcast detailing a new strain of lethal rabies that is now all over Montreal, she goes out to a sex cinema and is infected by a leering patron.
Claude LePointe is riding in a limo with a local health official to inform the mayor about the maddened situation. Just then, the limo is blocked at a construction sight, and two infected crewmen attack by putting a jackhammer through the limo door and dragging the driver out to feed on him, while the official and LePointe barely escape by driving away in reverse. Soon, the virus infection turns worsened and causes mass hysteria within the city; Dr. Royce Gentry advises on television a shoot-to-kill policy to prevent future infecting, extreme martial law is declared within the city of Montreal, and the doctor works on developing a cure while those already infected must be killed. National Guard road blocks have been set to check for people infected, and a convoy of NBC-suited soldiers ride into the city to assist the authorities with the body disposal. Meanwhile, Rose hides in Mindy's apartment and warns her not to come into her room, and Murray is killed by his infected wife in his house. Hart drives through the deserted city before an infected civilian jumps on his car and is shot dead by a militia marksman; the soldiers in bio-warfare suits dump the infected civilian's body in a garbage and spray disinfectant on Hart's car before permitting him to continue driving.
Mindy watches a report about a possible carrier of the disease being possibly immune, which has now been traced back to the Keloid Clinic. Rose walks into the room and feasts on Mindy before Hart enters and realizes that she is the virus's carrier. He tries to reason with her about treatment, but she refuses to believe him and is in denial that she is the cause responsible for the city-wide epidemic that has now claimed thousands of people. She tries to run and Hart chases after her, before he falls down an escape ladder and is rendered unconscious as she escapes with a man in the apartment's lobby. Testing Hart's accusations, Roses infects the man with her stinger and then locks herself in his apartment, staying inside until the infected man becomes sick. She dials Mindy's phone number and calls an awakened Hart to tell him what she is doing, but she frantically tells her to leave the apartment. He sits helplessly at the receiver, and the man rose infected awakens and approaches Rose. In the end, Montreal ends up suffered from the chaos the next morning and the bio-ware suited soldiers picks up Rose's body, laying next to garbage cans in an alley. The film ends with the soldiers dumping her body in the garbage truck and drive off, unbeknownst that she is the carrier and possibly the antidote solution to the epidemic.
Who awakens from a coma?
Rose