Metabolitul oxidativ major, M8 (terț-butil hidroxi nelfinavir) are activitate antivirală in vitro egală cu cea a medicamentului nemodificat iar formarea sa este catalizată de polimorfa citocromială CYP2C19.
1	Metabolitul	metabolit	NOUN	Ncmsry	Case=Acc,Nom|Definite=Def|Gender=Masc|Number=Sing	11	nsubj	_	_
2	oxidativ	oxidativ	ADJ	Afpms-n	Definite=Ind|Degree=Pos|Gender=Masc|Number=Sing	1	amod	_	_
3	major	major	ADJ	Afpms-n	Definite=Ind|Degree=Pos|Gender=Masc|Number=Sing	1	amod	_	SpaceAfter=No
4	,	,	PUNCT	COMMA	_	5	punct	_	_
5	M8	M8	PROPN	Np	_	1	appos	_	_
6	(	(	PUNCT	LPAR	_	7	punct	_	SpaceAfter=No
7	terț-butil	terț-butil	NOUN	Ncms-n	Definite=Ind|Gender=Masc|Number=Sing	5	nmod	_	_
8	hidroxi	hidroxi	ADJ	Afpms-n	Definite=Ind|Degree=Pos|Gender=Masc|Number=Sing	7	amod	_	_
9	nelfinavir	nelfinavir	NOUN	Ncms-n	Definite=Ind|Gender=Masc|Number=Sing	7	nmod	_	SpaceAfter=No
10	)	)	PUNCT	RPAR	_	7	punct	_	_
11	are	avea	VERB	Vmip3s	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	0	root	_	_
12	activitate	activitate	NOUN	Ncfsrn	Case=Acc,Nom|Definite=Ind|Gender=Fem|Number=Sing	11	obj	_	_
13	antivirală	antiviral	ADJ	Afpfsrn	Case=Acc,Nom|Definite=Ind|Degree=Pos|Gender=Fem|Number=Sing	12	amod	_	_
14	in	in	ADP	Spsa	AdpType=Prep|Case=Acc	12	amod	_	_
15	vitro	vitro	NOUN	Nc	_	14	fixed	_	_
16	egală	egal	ADJ	Afpfsrn	Case=Acc,Nom|Definite=Ind|Degree=Pos|Gender=Fem|Number=Sing	12	amod	_	_
17	cu	cu	ADP	Spsa	AdpType=Prep|Case=Acc	18	case	_	_
18	cea	acela	PRON	Pd3fsr	Case=Acc,Nom|Gender=Fem|Number=Sing|Person=3|PronType=Dem	16	obl:pmod	_	_
19	a	al	DET	Tsfs	Gender=Fem|Number=Sing|Poss=Yes|PronType=Prs	20	det	_	_
20	medicamentului	medicament	NOUN	Ncmsoy	Case=Dat,Gen|Definite=Def|Gender=Masc|Number=Sing	18	nmod	_	_
21	nemodificat	nemodificat	ADJ	Afpms-n	Definite=Ind|Degree=Pos|Gender=Masc|Number=Sing	20	amod	_	_
22	iar	iar	ADV	Rc	_	26	cc	_	_
23	formarea	formare	NOUN	Ncfsry	Case=Acc,Nom|Definite=Def|Gender=Fem|Number=Sing	26	nsubj:pass	_	_
24	sa	său	DET	Ds3fsrs	Case=Acc,Nom|Gender=Fem|Number=Sing|Number[psor]=Sing|Person=3|Poss=Yes|PronType=Prs	23	det	_	_
25	este	fi	AUX	Vaip3s	Mood=Ind|Number=Sing|Person=3|Tense=Pres|VerbForm=Fin	26	aux:pass	_	_
26	catalizată	cataliza	VERB	Vmp--sf	Gender=Fem|Number=Sing|VerbForm=Part	11	conj	_	_
27	de	de	ADP	Spsa	AdpType=Prep|Case=Acc	28	case	_	_
28	polimorfa	polimorfă	NOUN	Ncfsry	Case=Acc,Nom|Definite=Def|Gender=Fem|Number=Sing	26	obl:agent	_	_
29	citocromială	citocromială	ADJ	Afpfsrn	Case=Acc,Nom|Definite=Ind|Degree=Pos|Gender=Fem|Number=Sing	28	amod	_	_
30	CYP2C19	CYP2C19	PROPN	Np	_	28	nmod	_	SpaceAfter=No
31	.	.	PUNCT	PERIOD	_	11	punct	_	_
