James Clarkson
James Clarkson may refer to:

 James Clarkson (footballer) (born 1972), English-American head coach of the Houston Dash
 James S. Clarkson (1842–1918), American Republican National Committee chairman
 James A. Clarkson (1906–1970), American mathematician
 Buster Clarkson (1915–1989), American baseball player